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Conserved domains on  [gi|2570670583|gb|WMJ92595|]
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probable 26S proteasome non-ATPase regulatory subunit 3-like, partial [Epiphile epimenes]

Protein Classification

PCI domain-containing protein( domain architecture ID 10476698)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to Homo sapiens 26S proteasome non-ATPase regulatory subunit 13 and COP9 signalosome complex subunit 3

CATH:  1.25.40.250
Gene Ontology:  GO:0006511
PubMed:  9644972

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 321-400 8.87e-13

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 64.16  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570670583 321 PYFQLTQAVRMGNLQRFGEVLENFGPQ-FRSDHTFTLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSAEdAEFI 399
Cdd:pfam01399   2 AYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDE-VEKI 80


                  .
gi 2570670583 400 V 400
Cdd:pfam01399  81 L 81
 
Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 321-400 8.87e-13

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 64.16  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570670583 321 PYFQLTQAVRMGNLQRFGEVLENFGPQ-FRSDHTFTLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSAEdAEFI 399
Cdd:pfam01399   2 AYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDE-VEKI 80


                  .
gi 2570670583 400 V 400
Cdd:pfam01399  81 L 81
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 355-400 1.00e-05

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 43.38  E-value: 1.00e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2570670583  355 TLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSaEDAEFIV 400
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSV-PEVEKLV 45
 
Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 321-400 8.87e-13

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 64.16  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570670583 321 PYFQLTQAVRMGNLQRFGEVLENFGPQ-FRSDHTFTLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSAEdAEFI 399
Cdd:pfam01399   2 AYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDE-VEKI 80


                  .
gi 2570670583 400 V 400
Cdd:pfam01399  81 L 81
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 355-400 1.00e-05

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 43.38  E-value: 1.00e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2570670583  355 TLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSaEDAEFIV 400
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSV-PEVEKLV 45
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 317-397 6.36e-03

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


Pssm-ID: 462954  Cd Length: 137  Bit Score: 36.85  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2570670583 317 KSLAPYFQLTQAVRMGNLQRFGEVLENFGPqfrSDHTFTLILRLRQNVIKTAIRSIGLSYSRISPKDIARKLGLDSAEDA 396
Cdd:pfam10075  39 PEIQQLLTLEQLLWQGDYAKFYQTLKSNDW---SEDYTPFVSGLEDTIRDEIAALVGKAYESISADDLAELLGLDTPEEL 115


                  .
gi 2570670583 397 E 397
Cdd:pfam10075 116 K 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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