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Conserved domains on  [gi|2569152519|gb|WMI04181|]
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uncharacterized protein (KGM_22016), partial [Thyridia psidii]

Protein Classification

ATP-binding protein( domain architecture ID 11440662)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase

Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|16689629

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 1-222 1.12e-106

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 310.78  E-value: 1.12e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVqRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLR 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519 160 PGRLDRIMYVGMPATEDRFDILQKLTKGgtRPLLGpDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:COG1222   235 PGRFDRVIEVPLPDEEAREEILKIHLRD--MPLAD-DVDLDKLAKLTEGFSGADLKAIVTEAG 294
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 1-222 1.12e-106

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 310.78  E-value: 1.12e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVqRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLR 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519 160 PGRLDRIMYVGMPATEDRFDILQKLTKGgtRPLLGpDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:COG1222   235 PGRFDRVIEVPLPDEEAREEILKIHLRD--MPLAD-DVDLDKLAKLTEGFSGADLKAIVTEAG 294
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 9-169 9.05e-98

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 282.07  E-value: 9.05e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   9 LSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRT 88
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  89 CFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMY 168
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTLY 160


                  .
gi 2569152519 169 V 169
Cdd:cd19530   161 V 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-236 9.89e-93

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 287.57  E-value: 9.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRR-SSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARgARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLR 609

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569152519 160 PGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAAATQSLTNHIANGTLE 236
Cdd:TIGR01243 610 PGRFDRLILVPPPDEEARKEIFKIHTRSMP---LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKE 683
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 1-221 2.29e-81

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 248.59  E-value: 2.29e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:PRK03992  128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIG 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRsSHDNNGAARVVN----QLLTEMDGIESREGVFVLAASNRPDIIDPA 156
Cdd:PRK03992  208 EGARLVRELFELAREKAPSIIFIDEIDAIAAKR-TDSGTSGDREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDILDPA 286

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519 157 VLRPGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAA 221
Cdd:PRK03992  287 ILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMN---LADDVDLEELAELTEGASGADLKAICTEA 348
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 41-170 9.20e-59

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 182.02  E-value: 9.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNG 120
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2569152519 121 AARVVNQLLTEMDGIESREG-VFVLAASNRPDIIDPAVLrpGRLDRIMYVG 170
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNSkVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
cell_div_CdvC NF041006
cell division protein CdvC;
1-221 1.17e-53

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 176.85  E-value: 1.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEqLKKLGLsaPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:NF041006  100 VTFSDIVGLEDVKEALKEAIVYPSKRPD-LFPLGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSA-----PCVIFFDEFDALCPRRSShDNNGAARVVNQLLTEMDGIE---SREGVFVLAASNRPDI 152
Cdd:NF041006  177 EAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSS-EVGGEVRVRNQFLKEMDGLQdksENYHVYVIGATNKPWR 255

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569152519 153 IDPAVLRpgRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAA 221
Cdd:NF041006  256 LDEPFLR--RFQKRIYIPLPDREQRLELLKYYTSKIK---LENDVDLDELAEMTEGYTASDIRDIVQAA 319
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 38-170 9.76e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 79.72  E-value: 9.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   38 PSGVLLCGPPGCGKTLLAKAVANEAGVNFISVK-----------------GPELLNMYVGESERAVRTCFRRARNSAPCV 100
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  101 IFFDEFDALCPRRSSHDnngaaRVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPgRLDRIMYVG 170
Cdd:smart00382  82 LILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 41-76 4.14e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 40.53  E-value: 4.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEA-----GVNFISVkgPELLN 76
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFTTA--ADLVE 131
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 1-222 1.12e-106

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 310.78  E-value: 1.12e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVqRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLR 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519 160 PGRLDRIMYVGMPATEDRFDILQKLTKGgtRPLLGpDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:COG1222   235 PGRFDRVIEVPLPDEEAREEILKIHLRD--MPLAD-DVDLDKLAKLTEGFSGADLKAIVTEAG 294
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 9-169 9.05e-98

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 282.07  E-value: 9.05e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   9 LSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRT 88
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  89 CFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMY 168
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTLY 160


                  .
gi 2569152519 169 V 169
Cdd:cd19530   161 V 161
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 12-169 4.91e-96

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 277.63  E-value: 4.91e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYV 169
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDSSGVTdRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-236 9.89e-93

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 287.57  E-value: 9.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRR-SSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARgARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLR 609

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569152519 160 PGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAAATQSLTNHIANGTLE 236
Cdd:TIGR01243 610 PGRFDRLILVPPPDEEARKEIFKIHTRSMP---LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKE 683
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 3-226 1.79e-85

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 259.46  E-value: 1.79e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   3 WDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGES 82
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  83 ERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESRegVFVLAASNRPDIIDPAVLRpgR 162
Cdd:COG0464   236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRSD--VVVIAATNRPDLLDPALLR--R 311

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2569152519 163 LDRIMYVGMPATEDRFDILQKLTKGgtRPlLGPDVDLQMIADLTEGYTGADLSGLVRAAATQSL 226
Cdd:COG0464   312 FDEIIFFPLPDAEERLEIFRIHLRK--RP-LDEDVDLEELAEATEGLSGADIRNVVRRAALQAL 372
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 1-221 2.29e-81

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 248.59  E-value: 2.29e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:PRK03992  128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIG 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRsSHDNNGAARVVN----QLLTEMDGIESREGVFVLAASNRPDIIDPA 156
Cdd:PRK03992  208 EGARLVRELFELAREKAPSIIFIDEIDAIAAKR-TDSGTSGDREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDILDPA 286

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519 157 VLRPGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAA 221
Cdd:PRK03992  287 ILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMN---LADDVDLEELAELTEGASGADLKAICTEA 348
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 12-169 1.48e-79

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 235.87  E-value: 1.48e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19528     1 VKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRR--SSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMY 168
Cdd:cd19528    81 KARAAAPCVLFFDELDSIAKARggNIGDAGGAAdRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 160


                  .
gi 2569152519 169 V 169
Cdd:cd19528   161 I 161
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 12-169 4.91e-79

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 234.70  E-value: 4.91e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19529     1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRR-SSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYV 169
Cdd:cd19529    81 KARQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 1-238 7.80e-75

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 240.58  E-value: 7.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:TIGR01243 175 VTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRP 160
Cdd:TIGR01243 255 ESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRP 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569152519 161 GRLDRIMYVGMPATEDRFDILQKLTKggTRPlLGPDVDLQMIADLTEGYTGADLSGLVRAAATQSLTNHIANGTLEGE 238
Cdd:TIGR01243 335 GRFDREIVIRVPDKRARKEILKVHTR--NMP-LAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFE 409
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 12-168 1.02e-73

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 221.15  E-value: 1.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19526     1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRRsSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMY 168
Cdd:cd19526    81 RAQSAKPCILFFDEFDSIAPKR-GHDSTGVTdRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 5-165 5.18e-73

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 219.47  E-value: 5.18e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESER 84
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  85 AVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLD 164
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGRFD 160


                  .
gi 2569152519 165 R 165
Cdd:cd19503   161 R 161
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 1-222 1.85e-70

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 223.70  E-value: 1.85e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQlAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELM-EIVDFLKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRS---SHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAV 157
Cdd:TIGR01241 131 VGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglGGGNDEREQTLNQLLVEMDGFGTNTGVIVIAATNRPDVLDPAL 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519 158 LRPGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:TIGR01241 211 LRPGRFDRQVVVDLPDIKGREEILKVHAKNKK---LAPDVDLKAVARRTPGFSGADLANLLNEAA 272
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 12-169 3.49e-67

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 204.44  E-value: 3.49e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEqLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19481     1 LKASLREAVEAPRRGSR-LRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYV 169
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSSGESGELrRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
1-222 6.60e-65

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 211.43  E-value: 6.60e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQ-----LavlapvKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELL 75
Cdd:COG0465   139 VTFDDVAGVDEAKEELQeivdfL------KDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  76 NMYVG--ESeRaVRTCFRRARNSAPCVIFFDEFDALCPRR-----SSHDNngaaR--VVNQLLTEMDGIESREGVFVLAA 146
Cdd:COG0465   213 EMFVGvgAS-R-VRDLFEQAKKNAPCIIFIDEIDAVGRQRgaglgGGHDE----ReqTLNQLLVEMDGFEGNEGVIVIAA 286

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2569152519 147 SNRPDIIDPAVLRPGRLDRIMYVGMPATEDRFDILQKLTKGgtRPlLGPDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:COG0465   287 TNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARK--KP-LAPDVDLEVIARRTPGFSGADLANLVNEAA 359
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 2-169 4.95e-64

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 196.79  E-value: 4.95e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   2 TWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGE 81
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  82 SERAVRTCFRRARNSAPCVIFFDEFDALCPRRSShDNNGAARVVN----QLLTEMDGIESREGVFVLAASNRPDIIDPAV 157
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFD-SGTGGDREVQrtmlELLNQLDGFDPRGNIKVIMATNRPDILDPAL 159

                         170
                  ....*....|..
gi 2569152519 158 LRPGRLDRIMYV 169
Cdd:cd19502   160 LRPGRFDRKIEF 171
ftsH CHL00176
cell division protein; Validated
 1-222 8.78e-64

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 209.52  E-value: 8.78e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQlAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFE-EVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSH---DNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAV 157
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGiggGNDEREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAAL 338

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519 158 LRPGRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:CHL00176  339 LRPGRFDRQITVSLPDREGRLDILKVHARNKK---LSPDVSLELIARRTPGFSGADLANLLNEAA 400
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 1-169 1.83e-63

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 195.53  E-value: 1.83e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQlAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:cd19501     1 VTFKDVAGCEEAKEELK-EVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRR---SSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAV 157
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRgagLGGGHDEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159

                         170
                  ....*....|..
gi 2569152519 158 LRPGRLDRIMYV 169
Cdd:cd19501   160 LRPGRFDRQVYV 171
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
3-226 5.30e-63

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 197.03  E-value: 5.30e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   3 WDD-VGSlSQVRKDLQLaVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGE 81
Cdd:COG1223     1 LDDvVGQ-EEAKKKLKL-IIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  82 SERAVRTCFRRARNsAPCVIFFDEFDALCPRRS-SHDNNGAARVVNQLLTEMDGIesREGVFVLAASNRPDIIDPAVLRp 160
Cdd:COG1223    79 TARNLRKLFDFARR-APCVIFFDEFDAIAKDRGdQNDVGEVKRVVNALLQELDGL--PSGSVVIAATNHPELLDSALWR- 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2569152519 161 gRLDRIMYVGMPATEDRFDILQKLTKGGTRPLlgpDVDLQMIADLTEGYTGADLSGLVRAAATQSL 226
Cdd:COG1223   155 -RFDEVIEFPLPDKEERKEILELNLKKFPLPF---ELDLKKLAKKLEGLSGADIEKVLKTALKKAI 216
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 12-169 6.43e-63

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 193.88  E-value: 6.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  12 VRKDLQLAVLAPVKYPEqLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFR 91
Cdd:cd19527     1 VKKEILDTIQLPLEHPE-LFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  92 RARNSAPCVIFFDEFDALCPRRSSHDNNGAA--RVVNQLLTEMDGIE-SREGVFVLAASNRPDIIDPAVLRPGRLDRIMY 168
Cdd:cd19527    80 KARDAKPCVIFFDELDSLAPSRGNSGDSGGVmdRVVSQLLAELDGMSsSGQDVFVIGATNRPDLLDPALLRPGRFDKLLY 159


                  .
gi 2569152519 169 V 169
Cdd:cd19527   160 L 160
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 5-170 4.16e-61

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 189.18  E-value: 4.16e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESER 84
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  85 AVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLD 164
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFD 160


                  ....*.
gi 2569152519 165 RIMYVG 170
Cdd:cd19519   161 REIDIG 166
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 1-183 2.83e-59

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 194.93  E-value: 2.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVAN------EAGVN----FISVK 70
Cdd:TIGR03689 179 VTYADIGGLGSQIEQIRDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANslaariGAEGGgksyFLNIK 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  71 GPELLNMYVGESERAVRTCFRRARNSA----PCVIFFDEFDALCPRRSSH-DNNGAARVVNQLLTEMDGIESREGVFVLA 145
Cdd:TIGR03689 259 GPELLNKYVGETERQIRLIFQRAREKAsegrPVIVFFDEMDSLFRTRGSGvSSDVETTVVPQLLAEIDGVESLDNVIVIG 338

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2569152519 146 ASNRPDIIDPAVLRPGRLDRIMYVGMPATEDRFDILQK 183
Cdd:TIGR03689 339 ASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIFAK 376
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
2-222 6.90e-59

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 196.79  E-value: 6.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   2 TWDDVGSLSQVRKDLQlAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGE 81
Cdd:PRK10733  150 TFADVAGCDEAKEEVA-ELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  82 SERAVRTCFRRARNSAPCVIFFDEFDALCPRRSS-----HDNNgaARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPA 156
Cdd:PRK10733  229 GASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglgggHDER--EQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPA 306

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2569152519 157 VLRPGRLDRIMYVGMPATEDRFDILQKLTKggtRPLLGPDVDLQMIADLTEGYTGADLSGLVRAAA 222
Cdd:PRK10733  307 LLRPGRFDRQVVVGLPDVRGREQILKVHMR---RVPLAPDIDAAIIARGTPGFSGADLANLVNEAA 369
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 41-170 9.20e-59

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 182.02  E-value: 9.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNG 120
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2569152519 121 AARVVNQLLTEMDGIESREG-VFVLAASNRPDIIDPAVLrpGRLDRIMYVG 170
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNSkVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 1-226 8.06e-56

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 183.04  E-value: 8.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:PTZ00454  142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRssHD-NNGAARVVN----QLLTEMDGIESREGVFVLAASNRPDIIDP 155
Cdd:PTZ00454  222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKR--FDaQTGADREVQrillELLNQMDGFDQTTNVKVIMATNRADTLDP 299

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2569152519 156 AVLRPGRLDRIMYVGMPATEDRFDILQKLTkggTRPLLGPDVDLQMIADLTEGYTGADLSGLVRAAATQSL 226
Cdd:PTZ00454  300 ALLRPGRLDRKIEFPLPDRRQKRLIFQTIT---SKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAV 367
cell_div_CdvC NF041006
cell division protein CdvC;
1-221 1.17e-53

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 176.85  E-value: 1.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEqLKKLGLsaPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:NF041006  100 VTFSDIVGLEDVKEALKEAIVYPSKRPD-LFPLGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSA-----PCVIFFDEFDALCPRRSShDNNGAARVVNQLLTEMDGIE---SREGVFVLAASNRPDI 152
Cdd:NF041006  177 EAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSS-EVGGEVRVRNQFLKEMDGLQdksENYHVYVIGATNKPWR 255

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2569152519 153 IDPAVLRpgRLDRIMYVGMPATEDRFDILQKLTKGGTrplLGPDVDLQMIADLTEGYTGADLSGLVRAA 221
Cdd:NF041006  256 LDEPFLR--RFQKRIYIPLPDREQRLELLKYYTSKIK---LENDVDLDELAEMTEGYTASDIRDIVQAA 319
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 6-169 1.83e-52

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 167.14  E-value: 1.83e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   6 VGSLSQVRKDLQLAVLAPVKYPEqLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESERA 85
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPD-LFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  86 VRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIE--SREGVFVLAASNRPDIIDPAVLRpgRL 163
Cdd:cd19509    80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLnkPEDRVLVLGATNRPWELDEAFLR--RF 157


                  ....*.
gi 2569152519 164 DRIMYV 169
Cdd:cd19509   158 EKRIYI 163
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 5-165 2.56e-52

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 167.20  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESER 84
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  85 AVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGI----ESREGVFVLAASNRPDIIDPAVLRP 160
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALRRA 160


                  ....*
gi 2569152519 161 GRLDR 165
Cdd:cd19518   161 GRFDR 165
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 5-168 1.75e-49

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 159.98  E-value: 1.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAG-----VNFISVKGPELLNMYV 79
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  80 GESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLR 159
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPALRR 160


                  ....*....
gi 2569152519 160 PGRLDRIMY 168
Cdd:cd19517   161 PGRFDREFY 169
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 2-225 7.13e-49

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 166.10  E-value: 7.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   2 TWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGE 81
Cdd:PTZ00361  181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGD 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  82 SERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGA---ARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVL 158
Cdd:PTZ00361  261 GPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEkeiQRTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALI 340

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569152519 159 RPGRLDRIMYVGMPATEDRFDILQKLTkggTRPLLGPDVDLQMIADLTEGYTGADlsglVRAAATQS 225
Cdd:PTZ00361  341 RPGRIDRKIEFPNPDEKTKRRIFEIHT---SKMTLAEDVDLEEFIMAKDELSGAD----IKAICTEA 400
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 1-169 1.52e-45

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 150.01  E-value: 1.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPeQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:cd19521     4 VKWEDVAGLEGAKEALKEAVILPVKFP-HLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGI-ESREGVFVLAASNRPDIIDPAVLR 159
Cdd:cd19521    83 ESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVgNDSQGVLVLGATNIPWQLDSAIRR 162

                         170
                  ....*....|
gi 2569152519 160 pgRLDRIMYV 169
Cdd:cd19521   163 --RFEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 5-163 3.74e-45

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 148.73  E-value: 3.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLGL-SAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESE 83
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  84 RAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIES--REGVFVLAASNRPDIIDPAVLR-- 159
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTdgNCRVIVMGATNRPQDLDEAILRrm 160


                  ....
gi 2569152519 160 PGRL 163
Cdd:cd19520   161 PKRF 164
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 5-169 8.11e-43

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 142.82  E-value: 8.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKklGLSAP-SGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESE 83
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  84 RAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAA-RVVNQLLTEMDGI-------ESREGVFVLAASNRPDIIDP 155
Cdd:cd19522    79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASrRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDIDE 158

                         170
                  ....*....|....
gi 2569152519 156 AVLRpgRLDRIMYV 169
Cdd:cd19522   159 ALRR--RLEKRIYI 170
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 27-164 1.86e-39

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 134.54  E-value: 1.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  27 PEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAV-----ANEAGVnfisVKGPELLNMYVGESERAVRTCFRRAR------- 94
Cdd:cd19504    24 PEIVEQLGCKHVKGILLYGPPGTGKTLMARQIgkmlnAREPKI----VNGPEILNKYVGESEANIRKLFADAEeeqrrlg 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519  95 -NSAPCVIFFDEFDALCPRR-SSHDNNGAA-RVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLD 164
Cdd:cd19504   100 aNSGLHIIIFDEIDAICKQRgSMAGSTGVHdTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 5-169 2.43e-36

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 126.12  E-value: 2.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKklGLSAPS-GVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESE 83
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFT--GLRAPArGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  84 RAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGIESR--EGVFVLAASNRPDIIDPAVLRpg 161
Cdd:cd19524    79 KLVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNgdDRVLVMGATNRPQELDDAVLR-- 156


                  ....*...
gi 2569152519 162 RLDRIMYV 169
Cdd:cd19524   157 RFTKRVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 1-169 6.62e-36

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 125.49  E-value: 6.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLAPVKYPEQLKklGLSAP-SGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYV 79
Cdd:cd19525    19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRGPpKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  80 GESERAVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGAARVVNQLLTEMDGI--ESREGVFVLAASNRPDIIDPAV 157
Cdd:cd19525    97 GEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGAttSSEDRILVVGATNRPQEIDEAA 176

                         170
                  ....*....|..
gi 2569152519 158 LRpgRLDRIMYV 169
Cdd:cd19525   177 RR--RLVKRLYI 186
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 35-170 1.20e-29

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 108.39  E-value: 1.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  35 LSAPSGVLLCGPPGCGKTLLAKAVANEA---GVNFISVKGPELLNMYVGESER---AVRTCFRRARNSAPCVIFFDEFDA 108
Cdd:cd00009    16 LPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDS 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2569152519 109 LCPRRSshdnngaARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYVG 170
Cdd:cd00009    96 LSRGAQ-------NALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 5-169 6.43e-29

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 106.68  E-value: 6.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLApvkYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESER 84
Cdd:cd19507     1 DVGGLDNLKDWLKKRKAA---FSKQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESES 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  85 AVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNG-AARVVNQLLTEMDgiESREGVFVLAASNRPDIIDPAVLRPGRL 163
Cdd:cd19507    78 RLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSGtSSRVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELLRKGRF 155


                  ....*.
gi 2569152519 164 DRIMYV 169
Cdd:cd19507   156 DEIFFV 161
ycf46 CHL00195
Ycf46; Provisional
 1-215 2.88e-27

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 108.57  E-value: 2.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   1 VTWDDVGSLSQVRKDLQLAVLApvkYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVG 80
Cdd:CHL00195  225 EKISDIGGLDNLKDWLKKRSTS---FSKQASNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVG 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  81 ESERAVRTCFRRARNSAPCVIFFDEFD-ALCPRRSSHDNNGAARVVNQLLTEMDgiESREGVFVLAASNRPDIIDPAVLR 159
Cdd:CHL00195  302 ESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDLLPLEILR 379

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519 160 PGRLDRIMYVGMPATEDR---FDI-LQKLtkggtRPLLGPDVDLQMIADLTEGYTGADLS 215
Cdd:CHL00195  380 KGRFDEIFFLDLPSLEERekiFKIhLQKF-----RPKSWKKYDIKKLSKLSNKFSGAEIE 434
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 5-159 2.42e-20

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 84.55  E-value: 2.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   5 DVGSLSQVRKDLQLAVLAPVKYPEQLKKLgLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGESER 84
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2569152519  85 AVRTCFRRARNSAPCVIFFDEFDALCPRRSSHDNNGaARVVNQLLTEMDGIES--REGVFVLAASNRPDIIDPAVLR 159
Cdd:cd19523    80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEASPV-GRLQVELLAQLDGVLGsgEDGVLVVCTTSKPEEIDESLRR 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 38-170 9.76e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 79.72  E-value: 9.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519   38 PSGVLLCGPPGCGKTLLAKAVANEAGVNFISVK-----------------GPELLNMYVGESERAVRTCFRRARNSAPCV 100
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  101 IFFDEFDALCPRRSSHDnngaaRVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPgRLDRIMYVG 170
Cdd:smart00382  82 LILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 40-169 3.81e-13

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 65.07  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  40 GVLLCGPPGCGKTLLAKAVANEAGVNFIsvkgpeLLNMyvgeSERaVRTCFRRAR--NSAP--CVIFFDEFDA------L 109
Cdd:cd19510    25 GYLLYGPPGTGKSSFIAALAGELDYDIC------DLNL----SEV-VLTDDRLNHllNTAPkqSIILLEDIDAafesreH 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519 110 CPRRSSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYV 169
Cdd:cd19510    94 NKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 41-169 1.07e-11

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 62.08  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVN---------FISVKGPELLNMYVGESERAVRTCFRR------ARNSAPCVIFfDE 105
Cdd:cd19508    55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKiqelidDKDALVFVLI-DE 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2569152519 106 FDALCPRR----SSHDNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLrpGRLDRIMYV 169
Cdd:cd19508   134 VESLAAARsassSGTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAFV--DRADIKQYI 199
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 41-157 4.32e-10

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 56.38  E-value: 4.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYvGESERAVRTCFRRARNSAPCVIFF-DEFDALCPRRSSHDNN 119
Cdd:cd19512    25 ILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAIHKVFDWANTSRRGLLLFvDEADAFLRKRSTEKIS 103

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2569152519 120 GAAR-VVNQLLTEMdGIESREGVFVLaASNRPDIIDPAV 157
Cdd:cd19512   104 EDLRaALNAFLYRT-GEQSNKFMLVL-ASNQPEQFDWAI 140
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 32-169 5.49e-09

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 53.53  E-value: 5.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  32 KLGLSAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLN--------------MYVGESERAVRTCFRRARNSA 97
Cdd:cd19505     6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYnkpdfgnddwidgmLILKESLHRLNLQFELAKAMS 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2569152519  98 PCVIFFDEFDALCPRRSSH----DNNGAARVVNQLLTEMDGIESREGVFVLAASNRPDIIDPAVLRPGRLDRIMYV 169
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQnleeDPKLLLGLLLNYLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCINI 161
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 196-236 1.36e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 49.46  E-value: 1.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2569152519 196 DVDLQMIADLTEGYTGADLSGLVRAAATQSLTNHIANGTLE 236
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQE 41
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 42-152 5.34e-08

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 52.92  E-value: 5.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  42 LLCGPPGCGKTLLAKAVANE-AGV------NFISVKGPELLNMYVGESERAVRTCFRRARNSapcVIFFDEFDALCPRRS 114
Cdd:TIGR03922 316 LFAGPPGTGKTTIARVVAKIyCGLgvlrkpLVREVSRADLIGQYIGESEAKTNEIIDSALGG---VLFLDEAYTLVETGY 392

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2569152519 115 SHDNNGAARVVNQLLTEMDGieSREGVFVLAASNRPDI 152
Cdd:TIGR03922 393 GQKDPFGLEAIDTLLARMEN--DRDRLVVIGAGYRKDL 428
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 2-74 1.62e-07

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 49.42  E-value: 1.62e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519   2 TWDDVGSLSQVRKDLQLAVLAPVKYPEqlkklglsAPSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPEL 74
Cdd:pfam05496   5 TLDEYIGQEKVKENLKIFIEAAKQRGE--------ALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI 69
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
41-74 3.36e-07

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 50.13  E-value: 3.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGPEL 74
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL 87
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 2-74 1.60e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 48.07  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519   2 TWDDVGSLSQVRKDLQLAVLAPVKYPEQLKKlglsapsgVLLCGPPGCGKTLLAKAVANEAGVNFISVKGPEL 74
Cdd:TIGR00635   2 LLAEFIGQEKVKEQLQLFIEAAKMRQEALDH--------LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL 66
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 41-72 3.05e-06

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 47.38  E-value: 3.05e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGP 72
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
29-87 1.11e-05

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 45.73  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2569152519  29 QLKKLGLSAPSGVLLCGPPGCGKTLLAKAVANEAG--VNFISVKGPELLNMYVGESE---RAVR 87
Cdd:COG1224    55 KMIKEGKMAGKGILIVGPPGTGKTALAVAIARELGedTPFVAISGSEIYSAELKKTEflmQALR 118
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 41-205 1.34e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.16  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKG-PELL-------NMYVGESERavrtcFR-RARnsaP---CVIFFDEFDa 108
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLLpsdilgtYIYDQQTGE-----FEfRPG---PlfaNVLLADEIN- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519 109 lcprRSShdnngaARVVNQLLTEMD----GIESR-----EGVFVLAASNRPDIIDPAVLRPGRLDRIM---YVGMPATED 176
Cdd:COG0714   105 ----RAP------PKTQSALLEAMEerqvTIPGGtyklpEPFLVIATQNPIEQEGTYPLPEAQLDRFLlklYIGYPDAEE 174

                         170       180
                  ....*....|....*....|....*....
gi 2569152519 177 RFDILqKLTKGGTRPLLGPDVDLQMIADL 205
Cdd:COG0714   175 EREIL-RRHTGRHLAEVEPVLSPEELLAL 202
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 41-111 1.51e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 44.11  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGV---NFISVKGPELL-----NM-------YVGESERAVRTCFRRARnsAPCVIFFDE 105
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMeehsvSRligappgYVGYEEGGQLTEAVRRK--PYSIVLIDE 83


                  ....*.
gi 2569152519 106 FDALCP 111
Cdd:pfam07724  84 IEKAHP 89
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 40-93 1.83e-05

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 44.99  E-value: 1.83e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2569152519  40 GVLLCGPPGCGKTLLAKAVANEAG--VNFISVKGPELLNMYVGESErAVRTCFRRA 93
Cdd:pfam06068  52 AVLIAGPPGTGKTALAIAISKELGedTPFTSISGSEVYSLEMKKTE-ALTQAFRKA 106
PRK08116 PRK08116
hypothetical protein; Validated
 28-76 4.94e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 43.47  E-value: 4.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2569152519  28 EQLKKLGLsapsGVLLCGPPGCGKTLLAKAVAN---EAGVNFISVKGPELLN 76
Cdd:PRK08116  108 EEMKKENV----GLLLWGSVGTGKTYLAACIANeliEKGVPVIFVNFPQLLN 155
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 38-69 6.27e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 43.51  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2569152519  38 PSGVLLCGPPGCGKTLLAKAVANEAGVNFISV 69
Cdd:COG2256    49 LSSMILWGPPGTGKTTLARLIANATDAEFVAL 80
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
40-106 7.05e-05

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 42.85  E-value: 7.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2569152519  40 GVLLCGPPGCGKTLLAKAVANEA---G--VNFISVkgPELLN-MYVGESERAVRTCFRRARnSAPCVIfFDEF 106
Cdd:COG1484   101 NLILLGPPGTGKTHLAIALGHEAcraGyrVRFTTA--PDLVNeLKEARADGRLERLLKRLA-KVDLLI-LDEL 169
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 38-69 1.02e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 42.76  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2569152519  38 PSGVLLCGPPGCGKTLLAKAVANEAGVNFISV 69
Cdd:PRK13342   36 LSSMILWGPPGTGKTTLARIIAGATDAPFEAL 67
PRK04195 PRK04195
replication factor C large subunit; Provisional
 41-112 1.25e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.60  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFIsvkgpEL----------LNMYVGESERaVRTCFRRARNsapcVIFFDEFDALC 110
Cdd:PRK04195   42 LLLYGPPGVGKTSLAHALANDYGWEVI-----ELnasdqrtadvIERVAGEAAT-SGSLFGARRK----LILLDEVDGIH 111


                  ..
gi 2569152519 111 PR 112
Cdd:PRK04195  112 GN 113
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 32-107 1.83e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 41.01  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  32 KLGLSAPS---GVLL-CGPPGCGKTLLAKAVA---NEAGVNFISVKGPELLNM------------YVGESERAVRTcfRR 92
Cdd:cd19499    31 RAGLSDPNrpiGSFLfLGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGGQLT--EA 108

                          90
                  ....*....|....*
gi 2569152519  93 ARNSAPCVIFFDEFD 107
Cdd:cd19499   109 VRRKPYSVVLLDEIE 123
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 24-159 3.20e-04

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.92  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  24 VKYPEQ--LKKLGLSAPSG--VLLCGPPGCGKTLLAKAVANEAGVN--FISVKGPELLNMYVGESERAVRTCF------- 90
Cdd:cd00267     7 FRYGGRtaLDNVSLTLKAGeiVALVGPNGSGKSTLLRAIAGLLKPTsgEILIDGKDIAKLPLEELRRRIGYVPqlsggqr 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519  91 RR---ARN--SAPCVIFFDE-FDALcprrsshDNNGAARVVNqLLTEMdgieSREGVFVLAASNRPDIIDPAVLR 159
Cdd:cd00267    87 QRvalARAllLNPDLLLLDEpTSGL-------DPASRERLLE-LLREL----AEEGRTVIIVTHDPELAELAADR 149
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 41-76 4.14e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 40.53  E-value: 4.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEA-----GVNFISVkgPELLN 76
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFTTA--ADLVE 131
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 40-159 5.35e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.81  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  40 GVLLCGPPGCGKTLLAK------------AVANEAGVNFISVKGPelLNMYVGESERaVRTCFRRARNSApCVIFFDEFD 107
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErlaaalsnrpvfYVQLTRDTTEEDLFGR--RNIDPGGASW-VDGPLVRAAREG-EIAVLDEIN 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2569152519 108 alcpRRSSHdnngAARVVNQLLTE-----MDGIE----SREGVFVLAASNRPDI----IDPAVLR 159
Cdd:pfam07728  77 ----RANPD----VLNSLLSLLDErrlllPDGGElvkaAPDGFRLIATMNPLDRglneLSPALRS 133
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 21-57 5.43e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.83  E-value: 5.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2569152519  21 LAPVKYPEQLKKLGLSAPSG---VLLCGPPGCGKTLLAKA 57
Cdd:pfam01078   2 LADVKGQEQAKRALEIAAAGghnLLMIGPPGSGKTMLAKR 41
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 41-150 7.54e-04

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 39.05  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVKGPELLNMYVGES--ERAVRTCFRRARNSAPCVIFFDEFDALCPRR--SSH 116
Cdd:cd19506    29 LLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKvpKTE 108

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2569152519 117 DNNGAARVVNQLLTEMDGIESREGVFVLAASNRP 150
Cdd:cd19506   109 KQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRP 142
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 41-104 8.37e-04

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 37.58  E-value: 8.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2569152519  41 VLLCGPPGCGKTL----LAKAVANEAGVNFISV----KGPELLNMYVGEseravrtcfrrarnsaPCVIFFD 104
Cdd:pfam00910   1 IWLYGPPGCGKSTlakyLARALLKKLGLPKDSVysrnPDDDFWDGYTGQ----------------PVVIIDD 56
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 39-81 1.68e-03

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 38.88  E-value: 1.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2569152519  39 SGVLLCGPPGCGKTLLAK----------AVAN-----EAGvnfisvkgpellnmYVGE 81
Cdd:COG1219   110 SNILLIGPTGSGKTLLAQtlarildvpfAIADattltEAG--------------YVGE 153
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 43-67 2.68e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 37.15  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*
gi 2569152519  43 LCGPPGCGKTLLAKAVANEAGVNFI 67
Cdd:cd00464     4 LIGMMGAGKTTVGRLLAKALGLPFV 28
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
39-81 3.75e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 37.83  E-value: 3.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2569152519  39 SGVLLCGPPGCGKTLLAK----------AVAN-----EAGvnfisvkgpellnmYVGE 81
Cdd:PRK05342  109 SNILLIGPTGSGKTLLAQtlarildvpfAIADattltEAG--------------YVGE 152
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 41-56 5.12e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 37.71  E-value: 5.12e-03
                          10
                  ....*....|....*.
gi 2569152519  41 VLLCGPPGCGKTLLAK 56
Cdd:COG0606   214 LLMIGPPGSGKTMLAR 229
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 40-109 5.80e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 36.77  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2569152519  40 GVLLC--GPPGCGKTLLAKAVANEAGVNF--ISVKG----PEL---LNMYVGESERAVRTCFRRARNSAPcVIFFDEFDA 108
Cdd:cd19500    37 GPILClvGPPGVGKTSLGKSIARALGRKFvrISLGGvrdeAEIrghRRTYVGAMPGRIIQALKKAGTNNP-VFLLDEIDK 115


                  .
gi 2569152519 109 L 109
Cdd:cd19500   116 I 116
44 PHA02544
clamp loader, small subunit; Provisional
 38-71 5.95e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 37.28  E-value: 5.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2569152519  38 PSGVLLCGPPGCGKTLLAKAVANEAGVNFISVKG 71
Cdd:PHA02544   43 PNMLLHSPSPGTGKTTVAKALCNEVGAEVLFVNG 76
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 41-68 5.99e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|....*...
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFIS 68
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLS 29
Sigma54_activat pfam00158
Sigma-54 interaction domain;
28-69 6.58e-03

Sigma-54 interaction domain;


Pssm-ID: 425491 [Multi-domain]  Cd Length: 168  Bit Score: 36.23  E-value: 6.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2569152519  28 EQLKKLGLSaPSGVLLCGPPGCGKTLLAKAVANE---AGVNFISV 69
Cdd:pfam00158  13 EQAKRVAPT-DAPVLITGESGTGKELFARAIHQLsprADGPFVAV 56
PRK13764 PRK13764
ATPase; Provisional
 25-60 6.64e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 37.51  E-value: 6.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2569152519  25 KYPEQLKKLGLSAPSGVLLCGPPGCGKTLLAKAVAN 60
Cdd:PRK13764  244 NLSEKLKERLEERAEGILIAGAPGAGKSTFAQALAE 279
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 39-66 7.94e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 36.81  E-value: 7.94e-03
                          10        20
                  ....*....|....*....|....*...
gi 2569152519  39 SGVLLCGPPGCGKTLLAKAVANEAGVNF 66
Cdd:cd19497    51 SNILLIGPTGSGKTLLAQTLAKILDVPF 78
PRK04182 PRK04182
cytidylate kinase; Provisional
 45-68 9.43e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 35.94  E-value: 9.43e-03
                          10        20
                  ....*....|....*....|....
gi 2569152519  45 GPPGCGKTLLAKAVANEAGVNFIS 68
Cdd:PRK04182    7 GPPGSGKTTVARLLAEKLGLKHVS 30
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
41-70 9.66e-03

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 36.71  E-value: 9.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2569152519  41 VLLCGPPGCGKTLLAKAVANEAGVNFISVK 70
Cdd:COG0593    37 LFLYGGVGLGKTHLLHAIGNEALENNPGAR 66
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 45-68 9.93e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 35.54  E-value: 9.93e-03
                          10        20
                  ....*....|....*....|....
gi 2569152519  45 GPPGCGKTLLAKAVANEAGVNFIS 68
Cdd:cd02020     6 GPAGSGKSTVAKLLAKKLGLPYLD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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