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Conserved domains on  [gi|2556707627|gb|WKZ09232|]
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VgR, partial [Anastatus japonicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 324-365 2.35e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.42  E-value: 2.35e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  324 GKMYWSDWGEHPHISVANMDGAHRDFFIKENIAWPNGLTIDY 365
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 351-390 5.41e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   351 IKENIAWPNGLTIDYPSKRLYWVDAKLKVIESILLDGHDR 390
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 30-59 8.77e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   30 FRCGNGHCVDQNWVCDGVDDCKDKSDEMNC 59
Cdd:cd00112      6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1053-1086 1.16e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2556707627 1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDELSC 1086
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 929-961 1.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 1.30e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   929 TCDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-925 2.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDEDNC 925
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 970-1004 3.84e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 3.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  970 CGQNMFSCKNGRCVDVLLRCNGADDCEDNSDEADC 1004
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 852-886 2.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  852 CQPDEFACHDGECIKKTDRCNSIFDCKDHSDEQNC 886
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 261-300 2.93e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.93e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   261 EVIVTAGLGCPEDIAVDWIAGNIYFTDSGFKHIGVCSNNG 300
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 191-374 4.77e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14963:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 268  Bit Score: 53.06  E-value: 4.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  191 GDLYTGEaFMIYASKTSIRGYYLESKLKVpivdNLQHVVGVSVDDSYIYWSDIQLGDEAIFRilEDGTKREVIVTAG--- 267
Cdd:cd14963     72 ADLYNGR-IQVFDPDGKFLKYFPEKKDRV----KLISPAGLAIDDGKLYVSDVKKHKVIVFD--LEGKLLLEFGKPGsep 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  268 --LGCPEDIAVDwIAGNIYFTDSGFKHIGVCSNNGEFC-----TVIIKESTEKPRGIALLPsEGKMYWSDWGEHpHISVA 340
Cdd:cd14963    145 geLSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIkelngSPDGKSGFVNPRGIAVDP-DGNLYVVDNLSH-RVYVF 221

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2556707627  341 NMDGAHRDFF-----IKENIAWPNGLTIDyPSKRLYWVD 374
Cdd:cd14963    222 DEQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTD 259
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1106-1137 6.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 6.37e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627  1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
523-732 6.72e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.39  E-value: 6.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  523 RMSASVTPHHIDAITYDSIGDSIIGADEMNKSIFRIDAHTGIINHILPIVNELVRYIAFDNFGNNLYKSNTVQKKIEVHS 602
Cdd:COG3391     17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  603 LTTGE-KTEFTFTENPYDLVVVPEEGLMFVVFKADND-YHIDKVQMNGLGSrthlIEHGlIGPRiSLAYDLDTKRVFWAD 680
Cdd:COG3391     97 LATGKvVATIPVGGGPRGLAVDPDGGRLYVADSGNGRvSVIDTATGKVVAT----IPVG-AGPH-GIAVDPDGKRLYVAN 170

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2556707627  681 EGAGRI----ESIDTL-GQNRNLFRTGVTsPVNIAVLDD--EVFWTSHKSNRLNWANKK 732
Cdd:COG3391    171 SGSNTVsvivSVIDTAtGKVVATIPVGGG-PVGVAVSPDgrRLYVANRGSNTSNGGSNT 228
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 810-845 8.21e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 8.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627  810 CSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDEKDC 845
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1385-1427 1.46e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627  1385 KIIVHENLGIISGLTIDHHRSLLYWADNYDTTIECVDFNGDHR 1427
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
149-188 1.94e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.94e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2556707627   149 DKDECMEYGICAQG--CRNTIGSYYCTCEMGYElqpDGKNCK 188
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 768-804 3.70e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 3.70e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627  768 CRKNNGDCSHICLVTdSTKRLCACPFGFIINTDQKTC 804
Cdd:pfam14670    1 CSVNNGGCSHLCLNT-PGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1145-1178 1.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1145 CETNP--CDNVCHKTPAGPVCSCRDGYQLEADGKSC 1178
Cdd:pfam14670    1 CSVNNggCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 74-103 5.52e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 5.52e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   74 GKYLCHNKRCISLSATCNGKDDCGDDSDEN 103
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1013-1048 1.12e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1013 CTKDQYRCKNSTlCIAEKLRCNGNADCPMRDDEHDC 1048
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 391-431 5.53e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 5.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627   391 RTVLHDVAKHPYSIAI--FENLLYWSDWSTNSIHSCNkFTGKD 431
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1180-1211 5.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627 1180 DIDECQ-HNICS--QICTNREGSYSCSCFEGFALR 1211
Cdd:cd00054      1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1289-1328 3.13e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 3.13e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627  1289 RTTATNGVGRPETLVVDWVTDNVYFYDSKQiPSITACNID 1328
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 324-365 2.35e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.42  E-value: 2.35e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  324 GKMYWSDWGEHPHISVANMDGAHRDFFIKENIAWPNGLTIDY 365
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 351-390 5.41e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   351 IKENIAWPNGLTIDYPSKRLYWVDAKLKVIESILLDGHDR 390
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 30-59 8.77e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   30 FRCGNGHCVDQNWVCDGVDDCKDKSDEMNC 59
Cdd:cd00112      6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1053-1086 1.16e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2556707627 1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDELSC 1086
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 929-961 1.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 1.30e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   929 TCDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 930-961 2.31e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.31e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627  930 CDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-925 2.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDEDNC 925
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 970-1004 3.84e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 3.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  970 CGQNMFSCKNGRCVDVLLRCNGADDCEDNSDEADC 1004
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1053-1083 6.27e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 6.27e-09
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2556707627  1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDE 1083
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
929-961 7.70e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 7.70e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2556707627  929 TCDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-56 8.92e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 8.92e-09
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2556707627    26 TCNAFRCGNGHCVDQNWVCDGVDDCKDKSDE 56
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 305-347 1.78e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.78e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627   305 VIIKESTEKPRGIALLPSEGKMYWSDWGeHPHISVANMDGAHR 347
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 852-886 2.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  852 CQPDEFACHDGECIKKTDRCNSIFDCKDHSDEQNC 886
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
850-886 4.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 4.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627  850 SKCQPDEFACHDGECIKKTDRCNSIFDCKDHSDEQNC 886
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
970-1004 6.38e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 6.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  970 CGQNMFSCKNGRCVDVLLRCNGADDCEDNSDEADC 1004
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 271-376 6.50e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 55.76  E-value: 6.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  271 PEDIAVDWiaGNIYFTDSGFKHIGVCSNNGEFCTVIIKESTEK-----PRGIALLpSEGKMYWSDWGEHpHISVANMDGA 345
Cdd:cd14963     12 PMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVD-SDGNIYVADLYNG-RIQVFDPDGK 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2556707627  346 HRDFF----IKENIAWPNGLTIDypSKRLYWVDAK 376
Cdd:cd14963     88 FLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK 120
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
891-925 1.78e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 1.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDEDNC 925
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 969-1001 2.28e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.28e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   969 ECGQNMFSCKNGRCVDVLLRCNGADDCEDNSDE 1001
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-59 2.30e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627   25 KTC--NAFRCGNGHCVDQNWVCDGVDDCKDKSDEMNC 59
Cdd:pfam00057    1 STCspNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1053-1086 2.61e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2556707627 1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDELSC 1086
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 261-300 2.93e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.93e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   261 EVIVTAGLGCPEDIAVDWIAGNIYFTDSGFKHIGVCSNNG 300
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 891-922 3.79e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 3.79e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627   891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDE 922
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 191-374 4.77e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.06  E-value: 4.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  191 GDLYTGEaFMIYASKTSIRGYYLESKLKVpivdNLQHVVGVSVDDSYIYWSDIQLGDEAIFRilEDGTKREVIVTAG--- 267
Cdd:cd14963     72 ADLYNGR-IQVFDPDGKFLKYFPEKKDRV----KLISPAGLAIDDGKLYVSDVKKHKVIVFD--LEGKLLLEFGKPGsep 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  268 --LGCPEDIAVDwIAGNIYFTDSGFKHIGVCSNNGEFC-----TVIIKESTEKPRGIALLPsEGKMYWSDWGEHpHISVA 340
Cdd:cd14963    145 geLSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIkelngSPDGKSGFVNPRGIAVDP-DGNLYVVDNLSH-RVYVF 221

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2556707627  341 NMDGAHRDFF-----IKENIAWPNGLTIDyPSKRLYWVD 374
Cdd:cd14963    222 DEQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTD 259
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1106-1137 6.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 6.37e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627  1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
523-732 6.72e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.39  E-value: 6.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  523 RMSASVTPHHIDAITYDSIGDSIIGADEMNKSIFRIDAHTGIINHILPIVNELVRYIAFDNFGNNLYKSNTVQKKIEVHS 602
Cdd:COG3391     17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  603 LTTGE-KTEFTFTENPYDLVVVPEEGLMFVVFKADND-YHIDKVQMNGLGSrthlIEHGlIGPRiSLAYDLDTKRVFWAD 680
Cdd:COG3391     97 LATGKvVATIPVGGGPRGLAVDPDGGRLYVADSGNGRvSVIDTATGKVVAT----IPVG-AGPH-GIAVDPDGKRLYVAN 170

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2556707627  681 EGAGRI----ESIDTL-GQNRNLFRTGVTsPVNIAVLDD--EVFWTSHKSNRLNWANKK 732
Cdd:COG3391    171 SGSNTVsvivSVIDTAtGKVVATIPVGGG-PVGVAVSPDgrRLYVANRGSNTSNGGSNT 228
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1106-1137 7.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 7.44e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627 1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 810-845 8.21e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 8.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627  810 CSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDEKDC 845
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 851-883 1.30e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 1.30e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   851 KCQPDEFACHDGECIKKTDRCNSIFDCKDHSDE 883
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1385-1427 1.46e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627  1385 KIIVHENLGIISGLTIDHHRSLLYWADNYDTTIECVDFNGDHR 1427
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
149-188 1.94e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.94e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2556707627   149 DKDECMEYGICAQG--CRNTIGSYYCTCEMGYElqpDGKNCK 188
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 768-804 3.70e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 3.70e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627  768 CRKNNGDCSHICLVTdSTKRLCACPFGFIINTDQKTC 804
Cdd:pfam14670    1 CSVNNGGCSHLCLNT-PGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 157-187 7.35e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2556707627  157 GICAQGCRNTIGSYYCTCEMGYELQPDGKNC 187
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1145-1178 1.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1145 CETNP--CDNVCHKTPAGPVCSCRDGYQLEADGKSC 1178
Cdd:pfam14670    1 CSVNNggCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 74-103 5.52e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 5.52e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   74 GKYLCHNKRCISLSATCNGKDDCGDDSDEN 103
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 149-188 9.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 9.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  149 DKDECMEYGICAQG--CRNTIGSYYCTCEMGYElqpdGKNCK 188
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 810-842 9.85e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 9.85e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   810 CSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDE 842
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
228-420 9.98e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 9.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  228 VVGVSVDDSYIYWSDIQLGDEAIFRILEDGTKREVIVTAGLGCPEDIAVDWIAGN-IYFTDSGFKHIGV-CSNNGEFCTV 305
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSViDLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  306 IikESTEKPRGIALLPSEGKMYWSDWGEHpHISVanMDGAhrDFFIKENIA---WPNGLTIDYPSKRLY---WVDAKLKV 379
Cdd:COG3391    106 I--PVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTA--TGKVVATIPvgaGPHGIAVDPDGKRLYvanSGSNTVSV 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2556707627  380 IESIlLDGHDRRTVLH-DVAKHPYSIAI--FENLLYWSDWSTNS 420
Cdd:COG3391    179 IVSV-IDTATGKVVATiPVGGGPVGVAVspDGRRLYVANRGSNT 221
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1013-1048 1.12e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1013 CTKDQYRCKNSTlCIAEKLRCNGNADCPMRDDEHDC 1048
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 74-102 1.61e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*....
gi 2556707627    74 GKYLCHNKRCISLSATCNGKDDCGDDSDE 102
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 391-431 5.53e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 5.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627   391 RTVLHDVAKHPYSIAI--FENLLYWSDWSTNSIHSCNkFTGKD 431
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1180-1211 5.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627 1180 DIDECQ-HNICS--QICTNREGSYSCSCFEGFALR 1211
Cdd:cd00054      1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1180-1208 5.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.95e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627  1180 DIDECQ-HNICSQ--ICTNREGSYSCSCFEGF 1208
Cdd:smart00179    1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGY 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 655-696 7.07e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 7.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2556707627   655 LIEHGLIGPRiSLAYDLDTKRVFWADEGAGRIESIDTLGQNR 696
Cdd:smart00135    3 LLSSGLGHPN-GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 237-278 7.84e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 7.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  237 YIYWSDIQLgDEAIFRILEDGTKREVIVTAGLGCPEDIAVDW 278
Cdd:pfam00058    2 RLYWTDSSL-RASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
808-845 1.17e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.00  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2556707627  808 TSCSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDEKDC 845
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1184-1217 1.33e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1184 CQHN--ICSQICTNREGSYSCSCFEGFALRLNQISC 1217
Cdd:pfam14670    1 CSVNngGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1106-1137 1.58e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627 1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1013-1045 2.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 2.07e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627  1013 CTKDQYRCKNSTlCIAEKLRCNGNADCPMRDDE 1045
Cdd:smart00192    2 CPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 369-408 2.12e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 2.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  369 RLYWVDAKLK-VIESILLDGHDRRTVL-HDVAkHPYSIAIFE 408
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFtDDLQ-HPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1289-1328 3.13e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 3.13e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627  1289 RTTATNGVGRPETLVVDWVTDNVYFYDSKQiPSITACNID 1328
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLD 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 409-439 8.18e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 8.18e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2556707627  409 NLLYWSDWSTNSIHSCNKFTGKDFDTLFQKN 439
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDD 31
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 324-365 2.35e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.42  E-value: 2.35e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  324 GKMYWSDWGEHPHISVANMDGAHRDFFIKENIAWPNGLTIDY 365
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 351-390 5.41e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 5.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   351 IKENIAWPNGLTIDYPSKRLYWVDAKLKVIESILLDGHDR 390
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 30-59 8.77e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   30 FRCGNGHCVDQNWVCDGVDDCKDKSDEMNC 59
Cdd:cd00112      6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1053-1086 1.16e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.16e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2556707627 1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDELSC 1086
Cdd:cd00112      2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 929-961 1.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 1.30e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   929 TCDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 930-961 2.31e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.31e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627  930 CDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 891-925 2.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDEDNC 925
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 970-1004 3.84e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 3.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  970 CGQNMFSCKNGRCVDVLLRCNGADDCEDNSDEADC 1004
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1053-1083 6.27e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 6.27e-09
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2556707627  1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDE 1083
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
929-961 7.70e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 7.70e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2556707627  929 TCDDSQFKCNSGSCIPRNWECDGQIDCNDGSDE 961
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-56 8.92e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 8.92e-09
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2556707627    26 TCNAFRCGNGHCVDQNWVCDGVDDCKDKSDE 56
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 305-347 1.78e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.78e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627   305 VIIKESTEKPRGIALLPSEGKMYWSDWGeHPHISVANMDGAHR 347
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 852-886 2.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 2.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  852 CQPDEFACHDGECIKKTDRCNSIFDCKDHSDEQNC 886
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
850-886 4.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 4.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627  850 SKCQPDEFACHDGECIKKTDRCNSIFDCKDHSDEQNC 886
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
970-1004 6.38e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 6.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  970 CGQNMFSCKNGRCVDVLLRCNGADDCEDNSDEADC 1004
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 271-376 6.50e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 55.76  E-value: 6.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  271 PEDIAVDWiaGNIYFTDSGFKHIGVCSNNGEFCTVIIKESTEK-----PRGIALLpSEGKMYWSDWGEHpHISVANMDGA 345
Cdd:cd14963     12 PMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVD-SDGNIYVADLYNG-RIQVFDPDGK 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2556707627  346 HRDFF----IKENIAWPNGLTIDypSKRLYWVDAK 376
Cdd:cd14963     88 FLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK 120
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
891-925 1.78e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 1.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627  891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDEDNC 925
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 969-1001 2.28e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.28e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   969 ECGQNMFSCKNGRCVDVLLRCNGADDCEDNSDE 1001
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-59 2.30e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.30e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627   25 KTC--NAFRCGNGHCVDQNWVCDGVDDCKDKSDEMNC 59
Cdd:pfam00057    1 STCspNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1053-1086 2.61e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2556707627 1053 SATQFTCHNSNCIPLEWVCDRADDCGDGSDELSC 1086
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 261-300 2.93e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.93e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627   261 EVIVTAGLGCPEDIAVDWIAGNIYFTDSGFKHIGVCSNNG 300
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 891-922 3.79e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 3.79e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627   891 CSSVEYRCRDGKCISKYLVCNGMNDCDDFSDE 922
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 191-374 4.77e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.06  E-value: 4.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  191 GDLYTGEaFMIYASKTSIRGYYLESKLKVpivdNLQHVVGVSVDDSYIYWSDIQLGDEAIFRilEDGTKREVIVTAG--- 267
Cdd:cd14963     72 ADLYNGR-IQVFDPDGKFLKYFPEKKDRV----KLISPAGLAIDDGKLYVSDVKKHKVIVFD--LEGKLLLEFGKPGsep 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  268 --LGCPEDIAVDwIAGNIYFTDSGFKHIGVCSNNGEFC-----TVIIKESTEKPRGIALLPsEGKMYWSDWGEHpHISVA 340
Cdd:cd14963    145 geLSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIkelngSPDGKSGFVNPRGIAVDP-DGNLYVVDNLSH-RVYVF 221

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2556707627  341 NMDGAHRDFF-----IKENIAWPNGLTIDyPSKRLYWVD 374
Cdd:cd14963    222 DEQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTD 259
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1106-1137 6.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 6.37e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627  1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
523-732 6.72e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.39  E-value: 6.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  523 RMSASVTPHHIDAITYDSIGDSIIGADEMNKSIFRIDAHTGIINHILPIVNELVRYIAFDNFGNNLYKSNTVQKKIEVHS 602
Cdd:COG3391     17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  603 LTTGE-KTEFTFTENPYDLVVVPEEGLMFVVFKADND-YHIDKVQMNGLGSrthlIEHGlIGPRiSLAYDLDTKRVFWAD 680
Cdd:COG3391     97 LATGKvVATIPVGGGPRGLAVDPDGGRLYVADSGNGRvSVIDTATGKVVAT----IPVG-AGPH-GIAVDPDGKRLYVAN 170

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2556707627  681 EGAGRI----ESIDTL-GQNRNLFRTGVTsPVNIAVLDD--EVFWTSHKSNRLNWANKK 732
Cdd:COG3391    171 SGSNTVsvivSVIDTAtGKVVATIPVGGG-PVGVAVSPDgrRLYVANRGSNTSNGGSNT 228
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1106-1137 7.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 7.44e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627 1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 810-845 8.21e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 8.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627  810 CSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDEKDC 845
Cdd:cd00112      1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 851-883 1.30e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 1.30e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   851 KCQPDEFACHDGECIKKTDRCNSIFDCKDHSDE 883
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1385-1427 1.46e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.46e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627  1385 KIIVHENLGIISGLTIDHHRSLLYWADNYDTTIECVDFNGDHR 1427
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
149-188 1.94e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.94e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2556707627   149 DKDECMEYGICAQG--CRNTIGSYYCTCEMGYElqpDGKNCK 188
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 768-804 3.70e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 3.70e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2556707627  768 CRKNNGDCSHICLVTdSTKRLCACPFGFIINTDQKTC 804
Cdd:pfam14670    1 CSVNNGGCSHLCLNT-PGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 157-187 7.35e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2556707627  157 GICAQGCRNTIGSYYCTCEMGYELQPDGKNC 187
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1145-1178 1.18e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1145 CETNP--CDNVCHKTPAGPVCSCRDGYQLEADGKSC 1178
Cdd:pfam14670    1 CSVNNggCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 223-421 1.39e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.85  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  223 DNLQHVVGVSVDDS-YIYWSDIqlGDEAIFRILEDGTKREVIVTAGLGC-----PEDIAVDwIAGNIYFTDSGFKHIGVC 296
Cdd:cd05819     52 GQFNEPAGVAVDSDgNLYVADT--GNHRIQKFDPDGNFLASFGGSGDGDgefngPRGIAVD-SSGNIYVADTGNHRIQKF 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  297 SNNGEFCTVIIKESTEK-----PRGIAlLPSEGKMYWSDWGEHpHISVANMDGAHRDFFIKENIAW-----PNGLTIDyP 366
Cdd:cd05819    129 DPDGEFLTTFGSGGSGPgqfngPTGVA-VDSDGNIYVADTGNH-RIQVFDPDGNFLTTFGSTGTGPgqfnyPTGIAVD-S 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2556707627  367 SKRLYWVDAKLKVIESILLDGHDRRTVLHDVAKH-----PYSIAIF-ENLLYWSDWSTNSI 421
Cdd:cd05819    206 DGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDgqfnrPSGLAVDsDGNLYVADTGNNRI 266
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 74-103 5.52e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 5.52e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 2556707627   74 GKYLCHNKRCISLSATCNGKDDCGDDSDEN 103
Cdd:cd00112      4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1163-1183 5.81e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 41.24  E-value: 5.81e-05
                           10        20
                   ....*....|....*....|.
gi 2556707627 1163 CSCRDGYQLEADGKSCLDIDE 1183
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 149-188 9.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 9.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  149 DKDECMEYGICAQG--CRNTIGSYYCTCEMGYElqpdGKNCK 188
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 810-842 9.85e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.08  E-value: 9.85e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627   810 CSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDE 842
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
228-420 9.98e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 9.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  228 VVGVSVDDSYIYWSDIQLGDEAIFRILEDGTKREVIVTAGLGCPEDIAVDWIAGN-IYFTDSGFKHIGV-CSNNGEFCTV 305
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSViDLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  306 IikESTEKPRGIALLPSEGKMYWSDWGEHpHISVanMDGAhrDFFIKENIA---WPNGLTIDYPSKRLY---WVDAKLKV 379
Cdd:COG3391    106 I--PVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTA--TGKVVATIPvgaGPHGIAVDPDGKRLYvanSGSNTVSV 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2556707627  380 IESIlLDGHDRRTVLH-DVAKHPYSIAI--FENLLYWSDWSTNS 420
Cdd:COG3391    179 IVSV-IDTATGKVVATiPVGGGPVGVAVspDGRRLYVANRGSNT 221
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1013-1048 1.12e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1013 CTKDQYRCKNSTlCIAEKLRCNGNADCPMRDDEHDC 1048
Cdd:cd00112      1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 249-392 1.55e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  249 AIFRI-LEDGTKREVIVTAG--LGCPEDIAVDWiAGNIYFTDSGFK----HIGVCSNNGEFCTVIikESTEKPRGIALLP 321
Cdd:COG3386     70 GLVRFdPADGEVTVLADEYGkpLNRPNDGVVDP-DGRLYFTDMGEYlptgALYRVDPDGSLRVLA--DGLTFPNGIAFSP 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  322 SEGKMYWSDWGEHpHISVANMD-----GAHRDFF-IKENIAWPNGLTID---------YPSKRLYWVDAKLKVIESILL- 385
Cdd:COG3386    147 DGRTLYVADTGAG-RIYRFDLDadgtlGNRRVFAdLPDGPGGPDGLAVDadgnlwvalWGGGGVVRFDPDGELLGRIELp 225

                          170
                   ....*....|....*.
gi 2556707627  386 ---------DGHDRRT 392
Cdd:COG3386    226 errptnvafGGPDLRT 241
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 74-102 1.61e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*....
gi 2556707627    74 GKYLCHNKRCISLSATCNGKDDCGDDSDE 102
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 143-186 1.87e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.68  E-value: 1.87e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2556707627  143 KNNTCMDKDECMEYG-ICAQGCRNTIGSYYCTCEMGYELQPDGKN 186
Cdd:cd01475    180 QGKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 391-431 5.53e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 5.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2556707627   391 RTVLHDVAKHPYSIAI--FENLLYWSDWSTNSIHSCNkFTGKD 431
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1180-1211 5.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2556707627 1180 DIDECQ-HNICS--QICTNREGSYSCSCFEGFALR 1211
Cdd:cd00054      1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1180-1208 5.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.95e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2556707627  1180 DIDECQ-HNICSQ--ICTNREGSYSCSCFEGF 1208
Cdd:smart00179    1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGY 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 655-696 7.07e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 7.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2556707627   655 LIEHGLIGPRiSLAYDLDTKRVFWADEGAGRIESIDTLGQNR 696
Cdd:smart00135    3 LLSSGLGHPN-GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 237-278 7.84e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 7.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  237 YIYWSDIQLgDEAIFRILEDGTKREVIVTAGLGCPEDIAVDW 278
Cdd:pfam00058    2 RLYWTDSSL-RASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
808-845 1.17e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.00  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2556707627  808 TSCSDDEMKCsKNDKCIKKIQKCNGYEDCPDGEDEKDC 845
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1184-1217 1.33e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2556707627 1184 CQHN--ICSQICTNREGSYSCSCFEGFALRLNQISC 1217
Cdd:pfam14670    1 CSVNngGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
230-421 1.33e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 42.70  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  230 GVSVD-DSYIYWSDIQLGdeAIFRI-LEDGTKREVIVTAGLGcPEDIAVDwIAGNIYFTDSGFKHIG------------- 294
Cdd:COG4257     21 DVAVDpDGAVWFTDQGGG--RIGRLdPATGEFTEYPLGGGSG-PHGIAVD-PDGNLWFTDNGNNRIGridpktgeittfa 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  295 --------------------VCSNN-----------GEFCTVIIKESTEKPRGIALLPSeGKMYWSDWGEHPHISVANMD 343
Cdd:COG4257     97 lpgggsnphgiafdpdgnlwFTDQGgnrigrldpatGEVTEFPLPTGGAGPYGIAVDPD-GNLWVTDFGANAIGRIDPDT 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  344 GAHRDFFIKENIAWPNGLTIDyPSKRLYWVDA---KLKVIESIllDGHDRRTVLHDVAKHPYSIAI-FENLLYWSDWSTN 419
Cdd:COG4257    176 GTLTEYALPTPGAGPRGLAVD-PDGNLWVADTgsgRIGRFDPK--TGTVTEYPLPGGGARPYGVAVdGDGRVWFAESGAN 252


                   ..
gi 2556707627  420 SI 421
Cdd:COG4257    253 RI 254
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1106-1137 1.58e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2556707627 1106 CSKTQFACKSGFCLPLTMACDGEKQCLDGSDE 1137
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
548-726 1.66e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 42.31  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  548 ADEMNKSIFRIDAHTGIIN-HILPIVNELVRYIAFDNFGnNLYKSNTVQKKIEVHSLTTGEKTEFTFTE---NPYDLVVV 623
Cdd:COG4257     75 TDNGNNRIGRIDPKTGEITtFALPGGGSNPHGIAFDPDG-NLWFTDQGGNRIGRLDPATGEVTEFPLPTggaGPYGIAVD 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  624 PEEGLMFVVFKADndyHIDKVQMNGLGSRTHLIEHGLIGPRiSLAYDLDtKRVFWADEGAGRIESIDT-LGQNRNL-FRT 701
Cdd:COG4257    154 PDGNLWVTDFGAN---AIGRIDPDTGTLTEYALPTPGAGPR-GLAVDPD-GNLWVADTGSGRIGRFDPkTGTVTEYpLPG 228

                          170       180
                   ....*....|....*....|....*.
gi 2556707627  702 GVTSPVNIAVLDDEVFW-TSHKSNRL 726
Cdd:COG4257    229 GGARPYGVAVDGDGRVWfAESGANRI 254
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1013-1045 2.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.23  E-value: 2.07e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2556707627  1013 CTKDQYRCKNSTlCIAEKLRCNGNADCPMRDDE 1045
Cdd:smart00192    2 CPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 369-408 2.12e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 2.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2556707627  369 RLYWVDAKLK-VIESILLDGHDRRTVL-HDVAkHPYSIAIFE 408
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFtDDLQ-HPNAIAVDP 42
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 230-345 2.53e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 41.87  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  230 GVSVDDSyiywSDIQLGDEAIFRIL---EDGTKREVIVTAGLGC-----PEDIAVDwIAGNIYFTDSGFKHIGVCSNNGE 301
Cdd:cd14957    116 GIAVDSN----GNIYVADTGNHRIQvftSSGTFSYSIGSGGTGPgqfngPQGIAVD-SDGNIYVADTGNHRIQVFTSSGT 190

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2556707627  302 FCTVIIKESTEK-----PRGIAlLPSEGKMYWSDWGEHpHISVANMDGA 345
Cdd:cd14957    191 FQYTFGSSGSGPgqfsdPYGIA-VDSDGNIYVADTGNH-RIQVFTSSGA 237
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 268-406 2.90e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 41.49  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2556707627  268 LGCPEDIAVDwIAGNIYFTDSGFKHIGVCSNNGEFCTVIIKESTEK-----PRGIALLPsEGKMYWSDWGEHpHISVANM 342
Cdd:cd14961     10 LNNPTGVAVT-PTGRVVVADDGNKRIQVFDSDGNCLQQFGPKGDAGqdiryPLDVAVTP-DGHIVVTDAGDR-SVKVFSF 86

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2556707627  343 DGAHRdFFIKENIAWPNGLTIDyPSKRLYWVDAKLKVIESILLDGHD----RRTVLHDVAKHPYSIAI 406
Cdd:cd14961     87 DGRLK-LFVRKSFSLPWGVAVN-PSGEILVTDSEAGKLFVLTVDFKLgilkKGQKLCSQLCRPRFVAV 152
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1289-1328 3.13e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 3.13e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2556707627  1289 RTTATNGVGRPETLVVDWVTDNVYFYDSKQiPSITACNID 1328
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLD 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 409-439 8.18e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 8.18e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2556707627  409 NLLYWSDWSTNSIHSCNKFTGKDFDTLFQKN 439
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDD 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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