|
Name |
Accession |
Description |
Interval |
E-value |
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
1-804 |
0e+00 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 1603.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 1 MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPT 80
Cdd:PRK14939 3 MSNSYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVYEVVDNAIDEALAGHCDDITVTIHADGSVSVSDNGRGIPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 81 GIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGET 160
Cdd:PRK14939 83 DIHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELTIRRDGKIHEQEFEHGVPVAPLKVVGET 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 161 EQTGTRVRFWPSMDTFsNNTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNIEDHFHYKGGIKAFVEFLNKNKTPIHPNV 240
Cdd:PRK14939 163 DKTGTEVRFWPSPEIF-ENTEFDYDILAKRLRELAFLNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 241 FYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREGLV 320
Cdd:PRK14939 242 FYFSGEKDGIGVEVALQWNDSYQENVLCFTNNIPQRDGGTHLAGFRAALTRTINNYIEKEGLAKKAKVSLTGDDAREGLT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 321 AVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKGALDL 400
Cdd:PRK14939 322 AVLSVKVPDPKFSSQTKDKLVSSEVRPAVESLVNEKLSEFLEENPNEAKIIVGKIIDAARAREAARKARELTRRKGALDI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 401 AGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR 480
Cdd:PRK14939 402 AGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKARFDKMLSSQEIGTLITALGCGIGR 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 481 DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDEAMDEYQLSIA 560
Cdd:PRK14939 482 DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHLYIAQPPLYKVKKGKQEQYLKDDEALDDYLIELA 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 561 LDGASLYTNkHAPALKGEPLEKLVTEFNSVQKIIKRMERLYPLSLLNNLIYHPKLTEEELFDKTKVEEwiktlvtrlndr 640
Cdd:PRK14939 562 LEGATLHLA-DGPAISGEALEKLVKEYRAVRKIIDRLERRYPRAVLEALIYAPALDLDDLADEAAVAA------------ 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 641 eqhsssyshrlhenrerqmyepvlcvrthgvdtdylLDFDFVHGGEYHRITQLSDKLTNLIEEDAYIERGERRQPVSDFE 720
Cdd:PRK14939 629 ------------------------------------LDADFLTSAEYRRLVELAEKLRGLIEEGAYLERGERKQPVSSFE 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 721 QALNWLTKESRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENALKAA 800
Cdd:PRK14939 673 EALDWLLAEARKGLSIQRYKGLGEMNPEQLWETTMDPENRRLLQVTIEDAIAADEIFTTLMGDEVEPRREFIEENALNVA 752
|
....
gi 2502825569 801 NIDI 804
Cdd:PRK14939 753 NLDV 756
|
|
| gyrB |
TIGR01059 |
DNA gyrase, B subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
5-804 |
0e+00 |
|
DNA gyrase, B subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. Proteins scoring above the noise cutoff for this model and below the trusted cutoff for topoisomerase IV models probably should be designated GyrB. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273421 [Multi-domain] Cd Length: 654 Bit Score: 1094.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 5 YDSSSIKVLKGLDAVRKRPGMYIGDTDDgTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGIHE 84
Cdd:TIGR01059 1 YDASSIKVLEGLEAVRKRPGMYIGSTGE-TGLHHLVYEVVDNSIDEAMAGYCDTISVTINDDGSVTVEDNGRGIPVDIHP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 85 EEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGETEQTG 164
Cdd:TIGR01059 80 EEGISAVEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSVVNALSEWLEVTVFRDGKIYRQEFERGIPVGPLEVVGETKKTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 165 TRVRFWPSMDTFSNnTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNI--EDHFHYKGGIKAFVEFLNKNKTPIHPNVFY 242
Cdd:TIGR01059 160 TTVRFWPDPEIFET-TEFDFDILAKRLRELAFLNSGVKISLEDERDGKgkKVTFHYEGGIKSFVKYLNRNKEPLHEEIIY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 243 FSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREGLVAV 322
Cdd:TIGR01059 239 IKGEKEGIEVEVALQWNDGYSENILSFVNNINTREGGTHLEGFRSALTRVINSYAKNNKLLKESKPNLTGEDIREGLTAV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 323 ISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKGALDLAG 402
Cdd:TIGR01059 319 ISVKVPDPQFEGQTKTKLGNSEVRSIVESLVYEKLTEFFEENPQEAKAIVEKAILAAQAREAARKARELTRRKSALDSGG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 403 LPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDe 482
Cdd:TIGR01059 399 LPGKLADCSSKDPSKSELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILSNQEIGAIITALGCGIGKD- 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 483 YNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDEAMDeyqlsiald 562
Cdd:TIGR01059 478 FDLEKLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIENGYVYIAQPPLYKVKKGKKERYIKDDKEKD--------- 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 563 gaslytnkhapaLKGEPLEKLvtefnsvqkiikRMERLYplsllnnliyhpklTEEELfdktkvEEWIKTLVtrlndreq 642
Cdd:TIGR01059 549 ------------LVGEALEDL------------KALYIY--------------SDKEK------EEAKTQIP-------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 643 hsssyshrlhenrerqmyepvlcvrthgvdtdylldfdfvhggeyhritqlsdkltnlieedayiergerrqpvsdfeqa 722
Cdd:TIGR01059 --------------------------------------------------------------------------------
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 723 lnwlTKESRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENALKAANI 802
Cdd:TIGR01059 577 ----VHLGRKGIEIQRYKGLGEMNADQLWETTMDPESRTLLKVTIEDAVEADRIFSTLMGDEVEPRREFIEANALDVKNL 652
|
..
gi 2502825569 803 DI 804
Cdd:TIGR01059 653 DV 654
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
1-804 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 1091.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 1 MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDgTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPT 80
Cdd:COG0187 2 KKSNYDASSIQVLEGLEAVRKRPGMYIGSTDE-RGLHHLVWEIVDNSIDEALAGYCDRIEVTLHADGSVTVEDNGRGIPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 81 GIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGET 160
Cdd:COG0187 81 DIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKRDGKIYRQRFERGKPVGPLEKIGKT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 161 EQTGTRVRFWPSMDTFSNnTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNI--EDHFHYKGGIKAFVEFLNKNKTPIHP 238
Cdd:COG0187 161 DRTGTTVRFKPDPEIFET-TEFDYETLAERLRELAFLNKGLTITLTDEREEEpkEETFHYEGGIKDFVEYLNEDKEPLHP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 239 NVFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREG 318
Cdd:COG0187 240 EVIYFEGEKDGIEVEVALQWNDGYSENIHSFVNNINTPEGGTHETGFRTALTRVINDYARKNGLLKEKDKNLTGDDVREG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 319 LVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKGAL 398
Cdd:COG0187 320 LTAVISVKLPEPQFEGQTKTKLGNSEARGIVESVVSEKLEHYLEENPAEAKKILEKAILAARAREAARKARELVRRKSAL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 399 DLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGI 478
Cdd:COG0187 400 ESSGLPGKLADCSSKDPEESELFIVEGDSAGGSAKQGRDREFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 479 GrDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDEAMDEYQls 558
Cdd:COG0187 480 G-DDFDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHVYIAQPPLYRIKKGKKTYYAYSDAELDELL-- 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 559 ialdgaslytnkhapalkgepleklvtefnsvqkiikrmerlyplsllnnliyhpklteEELFDKTKVEewiktlvtrln 638
Cdd:COG0187 557 -----------------------------------------------------------KELKGKKKVE----------- 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 639 dreqhsssyshrlhenrerqmyepvlcvrthgvdtdylldfdfvhggeyhritqlsdkltnlieedayiergerrqpvsd 718
Cdd:COG0187 --------------------------------------------------------------------------------
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 719 feqalnwltkesrrglsIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENALK 798
Cdd:COG0187 567 -----------------IQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADEIFSLLMGDKVEPRREFIEENAKF 629
|
....*.
gi 2502825569 799 AANIDI 804
Cdd:COG0187 630 VRNLDI 635
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
1-804 |
0e+00 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 1068.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 1 MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDgTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPT 80
Cdd:PRK05644 4 KAQEYDASQIQVLEGLEAVRKRPGMYIGSTGE-RGLHHLVYEIVDNSIDEALAGYCDHIEVTINEDGSITVTDNGRGIPV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 81 GIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGET 160
Cdd:PRK05644 83 DIHPKTGKPAVEVVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKRDGKIYYQEYERGVPVTPLEVIGET 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 161 EQTGTRVRFWPSMDTFSNnTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNIE--DHFHYKGGIKAFVEFLNKNKTPIHP 238
Cdd:PRK05644 163 DETGTTVTFKPDPEIFET-TEFDYDTLATRLRELAFLNKGLKITLTDEREGEEkeETFHYEGGIKEYVEYLNRNKEPLHE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 239 NVFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREG 318
Cdd:PRK05644 242 EPIYFEGEKDGIEVEVAMQYNDGYSENILSFANNINTHEGGTHEEGFKTALTRVINDYARKNKLLKEKDDNLTGEDVREG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 319 LVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKGAL 398
Cdd:PRK05644 322 LTAVISVKHPEPQFEGQTKTKLGNSEVRGIVDSVVSEALSEFLEENPNVAKKIVEKAILAARAREAARKARELTRRKSAL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 399 DLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGI 478
Cdd:PRK05644 402 ESSSLPGKLADCSSKDPEESELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGTGI 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 479 GrDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEqYIKDDEAMDEyqls 558
Cdd:PRK05644 482 G-DDFDISKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYVYIAQPPLYKIKKGGKE-YAYSDEELDE---- 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 559 ialdgaslytnkhapalkgepleklvtefnsvqkIIKRMErlyplsllnnliyhpklteeelfdktkveewiktlvtrln 638
Cdd:PRK05644 556 ----------------------------------ILAELK---------------------------------------- 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 639 dreqhsssyshrlhenrerqmyepvlcvrthgvdtdylldfdfvhggeyhritqlsdkltnlieedayiergerrqpvsd 718
Cdd:PRK05644 --------------------------------------------------------------------------------
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 719 feqalnwltKESRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENALK 798
Cdd:PRK05644 562 ---------LKGNPKYGIQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADEIFSILMGDDVEPRREFIEENAKY 632
|
....*.
gi 2502825569 799 AANIDI 804
Cdd:PRK05644 633 VRNLDI 638
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
1-796 |
0e+00 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 861.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 1 MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDgTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPT 80
Cdd:PRK05559 4 MTNNYNADSIEVLEGLEPVRKRPGMYIGSTDT-RGLHHLVQEVIDNSVDEALAGHGKRIEVTLHADGSVSVRDNGRGIPV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 81 GIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGET 160
Cdd:PRK05559 83 GIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKRDGKVYRQRFEGGDPVGPLEVVGTA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 161 --EQTGTRVRFWPSMDTFSnNTEFQHDILAKRLRELSFLNSGVSIRLLDKRTniEDHFHYKGGIKAFVEFLNKNKTPIHP 238
Cdd:PRK05559 163 gkRKTGTRVRFWPDPKIFD-SPKFSPERLKERLRSKAFLLPGLTITLNDERE--RQTFHYENGLKDYLAELNEGKETLPE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 239 N-VFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKvSATGDDARE 317
Cdd:PRK05559 240 EfVGSFEGEAEGEAVEWALQWTDEGGENIESYVNLIPTPQGGTHENGFREGLLKAVREFAEKRNLLPKGK-KLEGEDVRE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 318 GLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKARemTRRKGA 397
Cdd:PRK05559 319 GLAAVLSVKIPEPQFEGQTKEKLGSREARRFVSGVVKDAFDLWLNQNPELAEKLAEKAIKAAQARLRAAKKV--KRKKKT 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 398 LDLAgLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCG 477
Cdd:PRK05559 397 SGPA-LPGKLADCTSQDPERTELFLVEGDSAGGSAKQARDREFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIG 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 478 IGrDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYikddeamdeyql 557
Cdd:PRK05559 476 PG-DSFDLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVEAGHVYIALPPLYRVDKGKKKIY------------ 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 558 siALDgaslytnkhapalkgepleklvtefnsvqkiikrmerlyplsllnnliyhpkltEEELfdktkvEEWIKTLVTRl 637
Cdd:PRK05559 543 --ALD------------------------------------------------------EEEK------EELLKKLGKK- 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 638 ndreqhsssyshrlhenrerqmyepvlcvrthgvdtdylldfdfvhggeyhritqlsdkltnlieedayiergerrqpvs 717
Cdd:PRK05559 --------------------------------------------------------------------------------
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2502825569 718 dfeqalnwltkesRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENA 796
Cdd:PRK05559 560 -------------GGKPEIQRFKGLGEMNPDQLWETTMDPETRRLVRVTIDDAEETEKLVDMLMGKKAEPRREWIEENG 625
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
35-796 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 806.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 35 GLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGG 114
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGYMDTIKVTIDKDNSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVSGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 115 LHGVGVSVVNALSEKLELVIRRDGKVHEQTYH-LGVPQSPLKVVGETEQTGTRVRFWPSMDTFSNNTEFQHDILAKRLRE 193
Cdd:smart00433 81 LHGVGASVVNALSTEFEVEVARDGKEYKQSFSnNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTTDDDFELLKRRLRE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 194 LSFLNSGVSIRLLDKRTNIEDHFHYKGGIKAFVEFLNKNKTPIHPNVFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNI 273
Cdd:smart00433 161 LAFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYSENIVSFVNNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 274 PQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVsaTGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLM 353
Cdd:smart00433 241 ATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNI--KGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGVEKIV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 354 NEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKgALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAK 433
Cdd:smart00433 319 SECLLSFLEENPVEASKIVEKVLLAAKARAAAKKARELTRKK-KLSSISLPGKLADASSAGPKKCELFLVEGDSAGGSAK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 434 QGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGrDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTF 513
Cdd:smart00433 398 SGRDRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIG-KDFDIEKLRYGKIIIMTDADVDGSHIKGLLLTF 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 514 FYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDEaMDEYqlsialdgaslytnkhapalkgepleklvtefnsvqki 593
Cdd:smart00433 477 FYRYMPPLIEAGFVYIAIPPLYKVTKGKKKYVYSFYS-LDEY-------------------------------------- 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 594 ikrmerlyplsllnnliyhpklteeelfdktkvEEWIKTlvtrlndreqhsssyshrlhenrerqmyepvlcvrthgvdt 673
Cdd:smart00433 518 ---------------------------------EKWLEK----------------------------------------- 523
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 674 dylldfdfvhggeyhritqlsdkltnlieedayiergerrqpvsdfeqalnwlTKESRRGLSIQRYKGLGEMNPEQLWET 753
Cdd:smart00433 524 -----------------------------------------------------TEGNKSKYEIQRYKGLGEMNADQLWET 550
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 2502825569 754 TMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIEENA 796
Cdd:smart00433 551 TMDPERRTLLFVTLDDADEADLIFSALMGDKVEPRKEWIEENA 593
|
|
| parE_Gpos |
TIGR01058 |
DNA topoisomerase IV, B subunit, Gram-positive; Operationally, topoisomerase IV is a type II ... |
1-795 |
0e+00 |
|
DNA topoisomerase IV, B subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation step of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130130 [Multi-domain] Cd Length: 637 Bit Score: 647.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 1 MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDdGTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPT 80
Cdd:TIGR01058 1 MASKYNADAIKILEGLDAVRKRPGMYIGSTD-SKGLHHLVWEIVDNSVDEVLAGYADNITVTLHKDNSITVQDDGRGIPT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 81 GIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLG-VPQSPLKVVGE 159
Cdd:TIGR01058 80 GIHQDGNISTVETVFTVLHAGGKFDQGGYKTAGGLHGVGASVVNALSSWLEVTVKRDGQIYQQRFENGgKIVQSLKKIGT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 160 TEQTGTRVRFWPSMDTFSNnTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNIEDHFHYKGGIKAFVEFLNKNKTPIHPn 239
Cdd:TIGR01058 160 TKKTGTLVHFHPDPTIFKT-TQFNSNIIKERLKESAFLLKKLKLTFTDKRTNKTTVFFYENGLVDFVDYINETKETLSQ- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 240 VFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREGL 319
Cdd:TIGR01058 238 VTYFEGEKNGIEVEVAFQFNDGDSENILSFANSVKTKEGGTHENGFKLAITDVINSYARKYNLLKEKDKNLEGSDIREGL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 320 VAVISVKVPDP--KFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTR--RK 395
Cdd:TIGR01058 318 SAIISVRIPEEliQFEGQTKSKLFSPEARNVVDEIVQDHLFFFLEENNNDAKLLIDKAIKARDAKEAAKKAREEKKsgKK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 396 GALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALG 475
Cdd:TIGR01058 398 PKKEKGILSGKLTPAQSKNPAKNELFLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAKLADILKNEEINTIIFCIG 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 476 CGIGRDeYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKV--KKGKQEQYIKDDEAMD 553
Cdd:TIGR01058 478 TGIGAD-FSIKDLKYDKIIIMTDADTDGAHIQVLLLTFFYRYMRPLIELGHVYIALPPLYKLskKDGKKVKYAWSDLELE 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 554 Eyqlsialdgaslytnkhapalkgepleklvtefnsvqkiikrmerlyplsllnnliyhpklteeelfdktkveewiktl 633
Cdd:TIGR01058 557 S------------------------------------------------------------------------------- 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 634 vtrlndreqhsssyshrlhenrerqmyepvlcvrthgvdtdylldfdfvhggeyhritqlsdkltnlieedayiergerr 713
Cdd:TIGR01058 --------------------------------------------------------------------------------
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 714 qpvsdfeqalnwlTKESRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIE 793
Cdd:TIGR01058 558 -------------VKKKLKNYTLQRYKGLGEMNADQLWETTMNPETRTLVRVKIDDLARAERQINTLMGDKVEPRKKWIE 624
|
..
gi 2502825569 794 EN 795
Cdd:TIGR01058 625 AN 626
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
3-796 |
5.08e-170 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 514.05 E-value: 5.08e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 3 NTYDSSSIKVLKGLDAVRKRPGMYIGDTDDgTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGI 82
Cdd:PTZ00109 98 SEYDADDIVVLEGLEAVRKRPGMYIGNTDE-KGLHQLLFEILDNSVDEYLAGECNKITVVLHKDGSVEISDNGRGIPCDV 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 83 HEEEGVSAAEVIMTVLHAGGKFDD----------------------------------------NSYKVSGGLHGVGVSV 122
Cdd:PTZ00109 177 SEKTGKSGLETVLTVLHSGGKFQDtfpknsrsdksedkndtksskkgksshvkgpkeakekessQMYEYSSGLHGVGLSV 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 123 VNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGE-TEQTGTRVRFWPSMDT-FSNNTE-------------FQHDIL 187
Cdd:PTZ00109 257 VNALSSFLKVDVFKGGKIYSIELSKGKVTKPLSVFSCpLKKRGTTIHFLPDYKHiFKTHHQhteteeeegckngFNLDLI 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 188 AKRLRELSFLNSGVSIRLLDKRTNIEDHF------HYKGGIKAFVEFLNKNKTPIHP--NVFYFSTEKDSIGVEVALQWN 259
Cdd:PTZ00109 337 KNRIHELSYLNPGLTFYLVDERIANENNFypyetiKHEGGTREFLEELIKDKTPLYKdiNIISIRGVIKNVNVEVSLSWS 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 260 DG-FQENIYCFTNNIpQRDGGTHLVGFRTAMTRTLNSYMDKEGYNKKSKVSATGDDAREGLVAVISVKVPDPKFSSQTKD 338
Cdd:PTZ00109 417 LEsYTALIKSFANNV-STTAGTHIDGFKYAITRCVNGNIKKNGYFKGNFVNIPGEFIREGMTAIISVKLNGAEFDGQTKT 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 339 KLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIDAARAREAARKAREMTRRKGALDLA-GLPGKLADCQERDPAL 417
Cdd:PTZ00109 496 KLGNHLLKTILESIVFEQLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAKDLIRQKNNQYYStILPGKLVDCISDDIER 575
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 418 SELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFD-KMLSSQEVATLITALGCGIGRDEYNPD---------- 486
Cdd:PTZ00109 576 NELFIVEGESAAGNAKQARNREFQAVLPLKGKILNIEKIKNNkKVFENSEIKLLITSIGLSVNPVTWRQYdlshgtkask 655
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 487 ---------------------KLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQy 545
Cdd:PTZ00109 656 desvqnnnstltkkknslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRMKQ- 734
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 546 ikddeamdeyqlsialdgaslytnkhapalkgepleklvteFNSVQKIIKRMERLYPLSLLNNLIyhpklteeELFDKTK 625
Cdd:PTZ00109 735 -----------------------------------------FNVSTKNSKKYIYTWSDEELNVLI--------KLLNKDY 765
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 626 VEEWIKTLVTRLNDREQHSSSYSHRLHENRErqmyepvlcVRTHGVDtdylldfdfvhggEYHRITQLSDKLTNLIEEDa 705
Cdd:PTZ00109 766 SSKETTRSVEEKGNAPDLDNEYEDEKLDNKN---------MRENNVD-------------EVELKTELGTNVADTEQTD- 822
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 706 yiergerrqpvsdfEQALNWLTKESRRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAV 785
Cdd:PTZ00109 823 --------------ELDINKAFFKFSKHYEIQRFKGLGEMMADQLWETTMDPKKRILIRITVSDAMRASELIFLLMGEDV 888
|
890
....*....|.
gi 2502825569 786 EPRRAFIEENA 796
Cdd:PTZ00109 889 QSRKQFIFENS 899
|
|
| parE_Gneg |
TIGR01055 |
DNA topoisomerase IV, B subunit, proteobacterial; Operationally, topoisomerase IV is a type II ... |
4-550 |
3.87e-150 |
|
DNA topoisomerase IV, B subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. This protein is active as an alpha(2)beta(2) heterotetramer. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130127 [Multi-domain] Cd Length: 625 Bit Score: 453.61 E-value: 3.87e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 4 TYDSSSIKVLKGLDAVRKRPGMYIgdtdDGTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGIH 83
Cdd:TIGR01055 3 NYSAKDIEVLDGLEPVRKRPGMYT----DTTRPNHLVQEVIDNSVDEALAGFASIIMVILHQDQSIEVFDNGRGMPVDIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 84 EEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGETEQ- 162
Cdd:TIGR01055 79 PKEGVSAVEVILTTLHAGGKFSNKNYHFSGGLHGVGISVVNALSKRVKIKVYRQGKLYSIAFENGAKVTDLISAGTCGKr 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 163 -TGTRVRFWPSMDTFSnNTEFQHDILAKRLRELSFLNSGVSIRLLDKRTNIEDHFHYKGGIKAFV-EFLNKNKTPIhPNV 240
Cdd:TIGR01055 159 lTGTSVHFTPDPEIFD-SLHFSVSRLYHILRAKAVLCRGVEIEFEDEVNNTKALWNYPDGLKDYLsEAVNGDNTLP-PKP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 241 FYFSTEKDSIGVEVALQW-NDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDKEGyNKKSKVSATGDDAREGL 319
Cdd:TIGR01055 237 FSGNFEGDDEAVEWALLWlPEGGELFMESYVNLIPTPQGGTHVNGLRQGLLDALREFCEMRN-NLPRGVKLTAEDIWDRC 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 320 VAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIIdaARAREAARKAREMTRRKGALD 399
Cdd:TIGR01055 316 SYVLSIKMQDPQFAGQTKERLSSRQVAKFVSGVIKDAFDLWLNQNVQLAEHLAEHAI--SSAQRRKRAAKKVVRKKLTSG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 400 LAgLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCgiG 479
Cdd:TIGR01055 394 PA-LPGKLADCTRQDLEGTELFLVEGDSAGGSAKQARDREYQAILPLWGKILNTWEVSLDKVLNSQEIHDIEVALGI--D 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2502825569 480 RDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQPPLYKVKKGKQEQYIKDDE 550
Cdd:TIGR01055 471 PDSNDLSQLRYGKICILADADSDGLHIATLLCALFFLHFPKLVEEGHVYVAKPPLYRIDLSKEVYYALDEE 541
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
36-216 |
8.45e-106 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 322.18 E-value: 8.45e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 36 LHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGL 115
Cdd:cd16928 1 LHHLVWEIVDNSIDEALAGYATEIEVTLHEDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 116 HGVGVSVVNALSEKLELVIRRDGKVHEQTYHLGVPQSPLKVVGETEQTGTRVRFWPSMDTFSnNTEFQHDILAKRLRELS 195
Cdd:cd16928 81 HGVGVSVVNALSERLEVEVKRDGKIYRQEFSRGGPLTPLEVIGETKKTGTTVRFWPDPEIFE-KTEFDFDTLKRRLRELA 159
|
170 180
....*....|....*....|.
gi 2502825569 196 FLNSGVSIRLLDKRTNIEDHF 216
Cdd:cd16928 160 FLNKGLKIVLEDERTGKEEVF 180
|
|
| TopoII_Trans_DNA_gyrase |
cd00822 |
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
220-377 |
1.16e-80 |
|
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are heterodimers composed of two subunits. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. E.coli DNA gyrase is a heterodimer composed of two subunits. E. coli DNA gyrase B subunit is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 238419 [Multi-domain] Cd Length: 172 Bit Score: 255.95 E-value: 1.16e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 220 GGIKAFVEFLNKNKTPIHPNVFYFSTEKDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMDK 299
Cdd:cd00822 1 GGLKDFVEELNKDKEPLHEEPIYIEGEKDGVEVEVALQWTDSYSENILSFVNNIPTPEGGTHETGFRAALTRAINDYAKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2502825569 300 EGYNKKSKVSATGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIID 377
Cdd:cd00822 81 NNLLKKKDVKLTGDDIREGLTAVISVKVPEPQFEGQTKDKLGNSEVRSIVESAVREALEEWLEENPEEAKKILEKAIL 158
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
418-532 |
8.72e-78 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 246.03 E-value: 8.72e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 418 SELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGrDEYNPDKLRYHSIIIMT 497
Cdd:cd03366 1 SELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG-EDFDLEKLRYHKIIIMT 79
|
90 100 110
....*....|....*....|....*....|....*
gi 2502825569 498 DADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQP 532
Cdd:cd03366 80 DADVDGAHIRTLLLTFFFRYMRPLIENGHVYIAQP 114
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
418-532 |
1.38e-68 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 221.61 E-value: 1.38e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 418 SELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMT 497
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRVFQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFDLDKLRYGKIIIMT 80
|
90 100 110
....*....|....*....|....*....|....*
gi 2502825569 498 DADVDGSHIRTLLLTFFYRQMPEIIERGHVFIAQP 532
Cdd:cd01030 81 DADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
221-377 |
1.94e-67 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 220.95 E-value: 1.94e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 221 GIKAFVEFLNKNKTPIHPNVFYFSTE--KDSIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNSYMD 298
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGEspDNRIEVEVALQWTDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2502825569 299 KEGYNKKSKVSATGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPNDAKTVVGKIID 377
Cdd:pfam00204 81 KKGLLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENPEIAKKILEKALQ 159
|
|
| GyrB_insert |
pfam18053 |
DNA gyrase B subunit insert domain; This is the insert domain found in DNA gyrase B subunit ... |
564-729 |
8.49e-62 |
|
DNA gyrase B subunit insert domain; This is the insert domain found in DNA gyrase B subunit proteins. Studies indicate that the insert has two functions, acting as a steric buttress to pre-configure the primary DNA-binding site, and serving as a relay that may help coordinate communication between different functional domains.
Pssm-ID: 465629 Cd Length: 167 Bit Score: 205.45 E-value: 8.49e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 564 ASLYTNKHAPALKGEPLEKLVTEFNSVQKIIKRMERLYPLSLLNNLIYHPKLTEEELFDKTKVEEWIKTLVTRLNDREQH 643
Cdd:pfam18053 1 AALYPNEGAPPISGEALEELARQYRLAEAIIKRLSRRYDPAVLEALLYLPPLDAEDLDDEAAAEAWAAALEARLNQDGLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 644 SSSYSHRLHENRERQMYEPVLCVRTHGVDTDYLLDFDFVHGGEYHRITQLSDKLTNLIEEDAYIERGERRQPVSDFEQAL 723
Cdd:pfam18053 81 GPRYRVSVEEDTERGKYLLRVTRRHHGNETVYVLDADFFESGDYRALAELGETLDGLIGEGAYIKRGEKEQPVESFKEAL 160
|
....*.
gi 2502825569 724 NWLTKE 729
Cdd:pfam18053 161 DWLMEE 166
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
22-543 |
9.67e-52 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 196.42 E-value: 9.67e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 22 RPGMYIGDTDDGT----------------------GLHHMVFEVVDNAID----EALAGHCSEVIVTI-HADNSVSVQDD 74
Cdd:PTZ00108 22 RPDTYIGSIETQTedmwvydeeknrmvyktityvpGLYKIFDEILVNAADnkarDKGGHRMTYIKVTIdEENGEISVYND 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 75 GRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIR--RDGKVHEQTY--HLGVP 150
Cdd:PTZ00108 102 GEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECVdsKSGKKFKMTWtdNMSKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 151 QSPLKVVGETEQTGTRVRFWPSMDTFsNNTEFQHDILA---KRLRELSFLNSGVSIRLLDKRTNIEDHFHYkggIKAFVE 227
Cdd:PTZ00108 182 SEPRITSYDGKKDYTKVTFYPDYAKF-GMTEFDDDMLRllkKRVYDLAGCFGKLKVYLNGERIAIKSFKDY---VDLYLP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 228 FLNKNKTPIHPNVFYFSTEKdsigVEVALQWNDGfQENIYCFTNNIPQRDGGTHLvgfrTAMTRTLNSYMDKE--GYNKK 305
Cdd:PTZ00108 258 DGEEGKKPPYPFVYTSVNGR----WEVVVSLSDG-QFQQVSFVNSICTTKGGTHV----NYILDQLISKLQEKakKKKKK 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 306 SKVSATGDdAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPndaktvvgkIIDAARAREAA 385
Cdd:PTZ00108 329 GKEIKPNQ-IKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSP---------ILENIVEWAQA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 386 RKAREMTRRKGALD---LAGLPgKLADCQERDPALSE---LYLVEGDSAGGSAKQG---RNRKNQAILPLKGKILNVEKA 456
Cdd:PTZ00108 399 KLAAELNKKMKAGKksrILGIP-KLDDANDAGGKNSEectLILTEGDSAKALALAGlsvVGRDYYGVFPLRGKLLNVRDA 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 457 RFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIE-RGhvFIAQ--PP 533
Cdd:PTZ00108 478 SLKQLMNNKEIQNLFKILGLDIGKKYEDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKnPG--FLKEfiTP 555
|
570
....*....|.
gi 2502825569 534 LYKV-KKGKQE 543
Cdd:PTZ00108 556 IVKAtKKGNQV 566
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
7-555 |
3.00e-50 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 186.50 E-value: 3.00e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 7 SSSIKVLKGLDAVRKRPGMYIGDTDDGT----------------GLHHMVFEVVDNAIDEALAG---HCSEVIVTIHaDN 67
Cdd:PHA02569 1 KDEFKVLSDREHILKRPGMYIGSVAYEAherflfgkftqveyvpGLVKIIDEIIDNSVDEAIRTnfkFANKIDVTIK-NN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 68 SVSVQDDGRGIPTGI---HEEEGVSAAEVIMTVLHAGGKFDDNSyKVSGGLHGVGVSVVNALSE---------KLELVIR 135
Cdd:PHA02569 80 QVTVSDNGRGIPQAMvttPEGEEIPGPVAAWTRTKAGSNFDDTN-RVTGGMNGVGSSLTNFFSVlfigetcdgKNEVTVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 136 RDGKVHEQTYHlgvpQSPLKVvgeteqTGTRVRFWPSMDTFSNNTEFQH--DILAKRLRELSFLNSGVSirlldkrtnie 213
Cdd:PHA02569 159 CSNGAENISWS----TKPGKG------KGTSVTFIPDFSHFEVNGLDQQylDIILDRLQTLAVVFPDIK----------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 214 dhFHYKGGIKAfveflnkNKTPIHPNVF---YFSTEKDSIGVEVALQwNDGFQENiyCFTNNIPQRDGGTHLVGFRTAMT 290
Cdd:PHA02569 218 --FTFNGKKVS-------GKFKKYAKQFgddTIVQENDNVSIALAPS-PDGFRQL--SFVNGLHTKNGGHHVDCVMDDIC 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 291 RTLnsymdKEGYNKKSKVSATGDDAREGLVAVISVK-VPDPKFSSQTKDKLVSS--EVKTAVEtLMNEKLVEYLLENPNd 367
Cdd:PHA02569 286 EEL-----IPMIKKKHKIEVTKARVKECLTIVLFVRnMSNPRFDSQTKERLTSPfgEIRNHID-LDYKKIAKQILKTEA- 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 368 aktVVGKIIDAARAREAARKAREMTR-RKGALDL-------AGLPGKLADcqerdpalSELYLVEGDSAGGSAKQGRNRK 439
Cdd:PHA02569 359 ---IIMPIIEAALARKLAAEKAAETKaAKKAKKAkvakhikANLIGKDAE--------TTLFLTEGDSAIGYLIEVRDEE 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 440 NQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEynpDKLRYHSIIIMTDADVDG-SHIRTLLLTFFYRqM 518
Cdd:PHA02569 428 LHGGYPLRGKVLNTWGMSYADILKNKELFDICAITGLVLGEKA---ENMNYKNIAIMTDADVDGkGSIYPLLLAFFSR-W 503
|
570 580 590
....*....|....*....|....*....|....*..
gi 2502825569 519 PEIIERGHVFIAQPPLYKVKKGKQEQYIKDdeaMDEY 555
Cdd:PHA02569 504 PELFEQGRIRFVKTPVIIAQVGKETKWFYS---LDEF 537
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
22-542 |
6.19e-43 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 168.73 E-value: 6.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 22 RPGMYIGDTDDGT--------------------GLHHMVFEVVDNAIDEALAG-HCSEVIVTIHAD-NSVSVQDDGRGIP 79
Cdd:PLN03128 19 RPDTYIGSTEKHTqtlwvyeggemvnrevtyvpGLYKIFDEILVNAADNKQRDpSMDSLKVDIDVEqNTISVYNNGKGIP 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 80 TGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSE--KLELVIRRDGKVHEQTY--HLGVPQSPLK 155
Cdd:PLN03128 99 VEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTefTVETADGNRGKKYKQVFtnNMSVKSEPKI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 156 VVGETEQTGTRVRFWPSMDTFsNNTEFQHDI---LAKRLRELS-FLNSGVSIRLLDKRTNIedhfhykGGIKAFVE-FLN 230
Cdd:PLN03128 179 TSCKASENWTKITFKPDLAKF-NMTRLDEDVvalMSKRVYDIAgCLGKKLKVELNGKKLPV-------KSFQDYVGlYLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 231 KNKTPIHPNVFYfstEKDSIGVEVALQWNDG-FQEniYCFTNNIPQRDGGTHLvgfrTAMTRTLNSYMdKEGYNKKSK-- 307
Cdd:PLN03128 251 PNSREDPLPRIY---EKVNDRWEVCVSLSDGsFQQ--VSFVNSIATIKGGTHV----DYVADQIVKHI-QEKVKKKNKna 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 308 VSATGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVeyllenpndaKTVVGK-IIDAARAREAAR 386
Cdd:PLN03128 321 THVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFL----------KKVEKCgVVENILSWAQFK 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 387 KAREMTRRKGA--LDLAGLPgKLADCQERDPALSE---LYLVEGDSAGGSAKQGR---NRKNQAILPLKGKILNVEKARF 458
Cdd:PLN03128 391 QQKELKKKDGAkrQRLTGIP-KLDDANDAGGKKSKdctLILTEGDSAKALAMSGLsvvGRDHYGVFPLRGKLLNVREASH 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 459 DKMLSSQEVATLITALGCGIGR--DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHvFIAQ--PPL 534
Cdd:PLN03128 470 KQIMKNAEITNIKQILGLQFGKtyDEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPG-FLVEfiTPI 548
|
....*...
gi 2502825569 535 YKVKKGKQ 542
Cdd:PLN03128 549 VKATKGGK 556
|
|
| DNA_gyraseB_C |
pfam00986 |
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA ... |
731-793 |
3.25e-41 |
|
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B protein is thought to catalyze the ATP-dependent super-coiling of DNA. See pfam00204. The carboxyl-terminal end supports the complexation with the DNA gyrase A protein and the ATP-independent relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,.
Pssm-ID: 460016 [Multi-domain] Cd Length: 63 Bit Score: 144.44 E-value: 3.25e-41
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2502825569 731 RRGLSIQRYKGLGEMNPEQLWETTMNPETRRMMRVTVKDAIATDQLFTTLMGDAVEPRRAFIE 793
Cdd:pfam00986 1 KKKVEIQRYKGLGEMNPEQLWETTMDPETRRLLQVTIEDAAEADEIFSTLMGDKVEPRREFIE 63
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
65-523 |
3.79e-32 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 134.99 E-value: 3.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 65 ADNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEklELVIRR-DG---KV 140
Cdd:PLN03237 109 EQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFST--EFVIETaDGkrqKK 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 141 HEQTY--HLGVPQSPLKVVGETEQTGTRVRFWPSMDTFsNNTEFQHDILA---KRLRELS-FLNSGVSIRLLDKRTNIed 214
Cdd:PLN03237 187 YKQVFsnNMGKKSEPVITKCKKSENWTKVTFKPDLAKF-NMTHLEDDVVAlmkKRVVDIAgCLGKTVKVELNGKRIPV-- 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 215 hfhykggiKAFVEFLN---KNKTPIHPNVFYFSTEKDSIGVEVALQWNDG-FQEniYCFTNNIPQRDGGTHLVGFRTAMT 290
Cdd:PLN03237 264 --------KSFSDYVDlylESANKSRPENLPRIYEKVNDRWEVCVSLSEGqFQQ--VSFVNSIATIKGGTHVDYVTNQIA 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 291 RTLNSYMDKEgyNKKSKVSATgdDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEyllenpndaKT 370
Cdd:PLN03237 334 NHVMEAVNKK--NKNANIKAH--NVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLK---------KV 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 371 VVGKIIDAARAREAARKAREMTRRKGA--LDLAGLPgKLADCQE---RDPALSELYLVEGDSAGGSAKQGRN---RKNQA 442
Cdd:PLN03237 401 MKSGIVENLLSWADFKQSKELKKTDGAktTRVTGIP-KLEDANEaggKNSEKCTLILTEGDSAKALAVAGLSvvgRNYYG 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 443 ILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEII 522
Cdd:PLN03237 480 VFPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQYESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL 559
|
.
gi 2502825569 523 E 523
Cdd:PLN03237 560 K 560
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
420-524 |
2.96e-24 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 98.53 E-value: 2.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 420 LYLVEGDSAGGSAKQGRN---RKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEY-NPDKLRYHSIII 495
Cdd:cd03365 3 LILTEGDSAKALAVAGLSvvgRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDYeSTKSLRYGRLMI 82
|
90 100
....*....|....*....|....*....
gi 2502825569 496 MTDADVDGSHIRTLLLTFFYRQMPEIIER 524
Cdd:cd03365 83 MTDQDHDGSHIKGLLINFIHSFWPSLLKI 111
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
222-340 |
3.48e-21 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 89.24 E-value: 3.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 222 IKAFVEFLNKNKTpiHPNVFYFSTEKDSIGVEVALQWND---GFQENIYCFTNNIPQRDGGTHLVGFRTAMTRTLNsymd 298
Cdd:cd00329 1 LKDRLAEILGDKV--ADKLIYVEGESDGFRVEGAISYPDsgrSSKDRQFSFVNGRPVREGGTHVKAVREAYTRALN---- 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2502825569 299 kegynkkskvsatGDDAREGLVAVISVKVPD--PKFS-SQTKDKL 340
Cdd:cd00329 75 -------------GDDVRRYPVAVLSLKIPPslVDVNvHPTKEEV 106
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
32-144 |
1.77e-18 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 81.54 E-value: 1.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 32 DGTGLHHMVFEVVDNAIDEALAGhcSEVIVTIHADN---SVSVQDDGRGIPtgiheeegvsaAEVIMTVLHAGGKFDDNS 108
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEG--GRITVTLERDGdhvEITVEDNGPGIP-----------PEDLEKIFEPFFRTDKRS 68
|
90 100 110
....*....|....*....|....*....|....*.
gi 2502825569 109 YKVSGglHGVGVSVVNALSEKLELVIRRDGKVHEQT 144
Cdd:smart00387 69 RKIGG--TGLGLSIVKKLVELHGGEISVESEPGGGT 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
31-171 |
1.13e-16 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 76.25 E-value: 1.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 31 DDGTGLHHMVFEVVDNAIDEALAGHCSEVIVTIHADNSVSVQDDGRGIPTGIHEeegvsaaevimtvlHAGGKFDDnSYK 110
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLP--------------RIFEPFST-ADK 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2502825569 111 VSGGLHGVGVSVVNALSEKLelvirrDGKVHeqtyhlgvpqsplkvVGETEQTGTRVRFWP 171
Cdd:pfam02518 66 RGGGGTGLGLSIVRKLVELL------GGTIT---------------VESEPGGGTTVTLTL 105
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
419-532 |
1.21e-15 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 72.77 E-value: 1.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 419 ELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLssqevatlitalgcgigrDEYNPDKLRYHSIIIMTD 498
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGFQAVVAVLGHLLSLEKGPKKKAL------------------KALKELALKAKEVILATD 62
|
90 100 110
....*....|....*....|....*....|....*.
gi 2502825569 499 ADVDGSHIRTLLLTFFyrqmpEIIER--GHVFIAQP 532
Cdd:pfam01751 63 PDREGEAIALKLLELK-----ELLENagGRVEFSEL 93
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
35-171 |
5.03e-13 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 66.98 E-value: 5.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 35 GLHHMVFEVVDNAID-EALAGHCSEVIVTIHAD-NSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVS 112
Cdd:cd16930 4 GLYKIFDEILVNAADnKQRDKSMTCIKVTIDPEnNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEKKVT 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2502825569 113 GGLHGVGVSVVNALSEK--LELVIRRDGKVHEQTY--HLGVPQSPLKVVGETEQTGTRVRFWP 171
Cdd:cd16930 84 GGRNGYGAKLCNIFSTEftVETADSESKKKFKQTWtnNMGKASEPKITPYEKGKDYTKVTFKP 146
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
36-170 |
8.21e-07 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 47.98 E-value: 8.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 36 LHHMVFEVVDNAIDEALAGhcSEVIVTIHADNS---VSVQDDGRGIPTGIHEeegvsaaevimtvlHAGGKFDDNSYKVS 112
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPG--GTIEISLRQEGDgvvLEVEDNGPGIPEEDLE--------------RIFERFYRGDKSRE 64
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2502825569 113 GGLHGVGVSVVNALSEKLelvirrDGKVHeqtyhlgvpqsplkvVGETEQTGTRVRFW 170
Cdd:cd00075 65 GGGTGLGLAIVRRIVEAH------GGRIT---------------VESEPGGGTTFTVT 101
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
418-522 |
1.46e-05 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 43.95 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2502825569 418 SELYLVEGDSAGGSAKQGRnRKNQAILPLKGKILNvekarfdkmlssQEVATLITALGcgigrdeynpdklRYHSIIIMT 497
Cdd:cd00188 1 KKLIIVEGPSDALALAQAG-GYGGAVVALGGHALN------------KTRELLKRLLG-------------EAKEVIIAT 54
|
90 100
....*....|....*....|....*
gi 2502825569 498 DADVDGSHIRTLLLTFFYRQMPEII 522
Cdd:cd00188 55 DADREGEAIALRLLELLKSLGKKVR 79
|
|
| |
