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Conserved domains on  [gi|1539298845|emb|VDZ62052|]
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N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA [Citrobacter freundii]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 15-311 3.78e-15

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03801:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 366  Bit Score: 75.27  E-value: 3.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  15 HLYNDFSGSPRVLREMISTVSSEKHLITsdgegVLSdidGVEYHQFRYIPNSNKFVKLYQFVVANIIIFHMLYRLLKANK 94
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARGHDVT-----VLT---PADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  95 GQEQHVIV--NTMLPFGAMFAARIMKVRTTVYIHETSIKPILL-----KKFLRFCIN--KCASETIFVSNYLFET-EKLE 164
Cdd:cd03801    80 LRKFDVVHahGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLllaaeRRLLARAEAllRRADAVIAVSEALRDElRALG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 165 NITNQY--VIYNPLSNSLITPIDELDIDAKYHGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMV---------- 232
Cdd:cd03801   160 GIPPEKivVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVggdgplrael 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 233 --LNCSVTQFNSFLKEREiprnvtmynrPKNLRGLYQMSSFVLNLSTPewiETFGLTLVEGMANGAIPIGPVTGGPAEII 310
Cdd:cd03801   240 eeLELGLGDRVRFLGFVP----------DEELPALYAAADVFVLPSRY---EGFGLVVLEAMAAGLPVVATDVGGLPEVV 306


                  .
gi 1539298845 311 K 311
Cdd:cd03801   307 E 307
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 15-311 3.78e-15

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 75.27  E-value: 3.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  15 HLYNDFSGSPRVLREMISTVSSEKHLITsdgegVLSdidGVEYHQFRYIPNSNKFVKLYQFVVANIIIFHMLYRLLKANK 94
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARGHDVT-----VLT---PADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  95 GQEQHVIV--NTMLPFGAMFAARIMKVRTTVYIHETSIKPILL-----KKFLRFCIN--KCASETIFVSNYLFET-EKLE 164
Cdd:cd03801    80 LRKFDVVHahGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLllaaeRRLLARAEAllRRADAVIAVSEALRDElRALG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 165 NITNQY--VIYNPLSNSLITPIDELDIDAKYHGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMV---------- 232
Cdd:cd03801   160 GIPPEKivVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVggdgplrael 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 233 --LNCSVTQFNSFLKEREiprnvtmynrPKNLRGLYQMSSFVLNLSTPewiETFGLTLVEGMANGAIPIGPVTGGPAEII 310
Cdd:cd03801   240 eeLELGLGDRVRFLGFVP----------DEELPALYAAADVFVLPSRY---EGFGLVVLEAMAAGLPVVATDVGGLPEVV 306


                  .
gi 1539298845 311 K 311
Cdd:cd03801   307 E 307
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 198-314 1.33e-10

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 58.82  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 198 VLFLSSLVPYKGLDdfLAIAKMAIVKSQDINFHMVLNCSVTQFNSFLK---EREIPRNVTMYNR--PKNLRGLYQMSS-F 271
Cdd:pfam00534   5 ILFVGRLEPEKGLD--LLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKlaeKLGLGDNVIFLGFvsDEDLPELLKIADvF 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1539298845 272 VLNLSTpewiETFGLTLVEGMANGAIPIGPVTGGPAEIIKSAF 314
Cdd:pfam00534  83 VLPSRY----EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGE 121
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 262-319 1.26e-04

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 41.13  E-value: 1.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539298845 262 LRGLYQMSSFVLNlstPEWIETFGLTLVEGMANGAIPIGPVTGGPAEIIKSAFWLYYI 319
Cdd:COG0438    14 LEALLAAADVFVL---PSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLV 68
PLN00142 PLN00142
sucrose synthase
 278-314 8.79e-03

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 37.65  E-value: 8.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1539298845 278 PEWIETFGLTLVEGMANGAIPIGPVTGGPAEII---KSAF 314
Cdd:PLN00142  673 PALYEAFGLTVVEAMTCGLPTFATCQGGPAEIIvdgVSGF 712
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 15-311 3.78e-15

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 75.27  E-value: 3.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  15 HLYNDFSGSPRVLREMISTVSSEKHLITsdgegVLSdidGVEYHQFRYIPNSNKFVKLYQFVVANIIIFHMLYRLLKANK 94
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARGHDVT-----VLT---PADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  95 GQEQHVIV--NTMLPFGAMFAARIMKVRTTVYIHETSIKPILL-----KKFLRFCIN--KCASETIFVSNYLFET-EKLE 164
Cdd:cd03801    80 LRKFDVVHahGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLllaaeRRLLARAEAllRRADAVIAVSEALRDElRALG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 165 NITNQY--VIYNPLSNSLITPIDELDIDAKYHGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMV---------- 232
Cdd:cd03801   160 GIPPEKivVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVggdgplrael 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 233 --LNCSVTQFNSFLKEREiprnvtmynrPKNLRGLYQMSSFVLNLSTPewiETFGLTLVEGMANGAIPIGPVTGGPAEII 310
Cdd:cd03801   240 eeLELGLGDRVRFLGFVP----------DEELPALYAAADVFVLPSRY---EGFGLVVLEAMAAGLPVVATDVGGLPEVV 306


                  .
gi 1539298845 311 K 311
Cdd:cd03801   307 E 307
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 85-310 8.32e-11

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 62.40  E-value: 8.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  85 MLYRLLKANKGQEQHVI-VNTMLPFGAMFA--ARIMKVRTTVYIHETSIKPI----LLKKFLRFCINKCASeTIFVSNYL 157
Cdd:cd03798    83 SLAKLLKRRRRGPPDLIhAHFAYPAGFAAAllARLYGVPYVVTEHGSDINVFpprsLLRKLLRWALRRAAR-VIAVSKAL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 158 feTEKLENIT----NQYVIYNPLSNSLITPIDElDIDAKYHGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMV- 232
Cdd:cd03798   162 --AEELVALGvprdRVDVIPNGVDPARFQPEDR-GLGLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVg 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 233 ----------------LNCSVTQFNSFLKErEIPRnvtMYNRpknlrglyqMSSFVLnlstPEWIETFGLTLVEGMANGA 296
Cdd:cd03798   239 dgplrealralaedlgLGDRVTFTGRLPHE-QVPA---YYRA---------CDVFVL----PSRHEGFGLVLLEAMACGL 301

                         250
                  ....*....|....
gi 1539298845 297 IPIGPVTGGPAEII 310
Cdd:cd03798   302 PVVATDVGGIPEVV 315
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 198-314 1.33e-10

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 58.82  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 198 VLFLSSLVPYKGLDdfLAIAKMAIVKSQDINFHMVLNCSVTQFNSFLK---EREIPRNVTMYNR--PKNLRGLYQMSS-F 271
Cdd:pfam00534   5 ILFVGRLEPEKGLD--LLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKlaeKLGLGDNVIFLGFvsDEDLPELLKIADvF 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1539298845 272 VLNLSTpewiETFGLTLVEGMANGAIPIGPVTGGPAEIIKSAF 314
Cdd:pfam00534  83 VLPSRY----EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGE 121
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 14-311 4.87e-10

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 59.92  E-value: 4.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  14 VHLYNDFSGSPRVLREMISTVSS---EKHLITSDGEGVLSDI--DGVEYHQfryIPNSNKFVKLYQFVVAniiIFHmLYR 88
Cdd:cd03808     3 LFIVNVDGGFQSFRLPLIKALVKkgyEVHVIAPDGDKLSDELkeLGVKVID---IPILRRGINPLKDLKA---LFK-LYK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  89 LLKANKGQeqhvIVNTMLPFGAMF---AARIMKVRTTVY----IHETSIKPILLKKFLRFCIN---KCASETIFVSNYLF 158
Cdd:cd03808    76 LLKKEKPD----IVHCHTPKPGILgrlAARLAGVPKVIYtvhgLGFVFTEGKLLRLLYLLLEKlalLFTDKVIFVNEDDR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 159 E--TEKLENITNQYVIYNPLSNSL--ITPIDELDIDAKYHgrnVLFLSSLVPYKGLDDFLAIAKmaIVKSQDINFHMVL- 233
Cdd:cd03808   152 DlaIKKGIIKKKKTVLIPGSGVDLdrFQYSPESLPSEKVV---FLFVARLLKDKGIDELIEAAK--ILKKKGPNVRFLLv 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 234 ------NCSVTQFNSFLKEReiprNVTMYNRPKNLRGLY-QMSSFVLnlstPEWIETFGLTLVEGMANGaIPIgpVT--- 303
Cdd:cd03808   227 gdgeleNPSEILIEKLGLEG----RIEFLGFRSDVPELLaESDVFVL----PSYREGLPRSLLEAMAAG-RPV--ITtdv 295


                  ....*...
gi 1539298845 304 GGPAEIIK 311
Cdd:cd03808   296 PGCRELVI 303
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 101-311 6.99e-10

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 59.26  E-value: 6.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 101 IVNTM----LPFGAMFAARIMKVRTTVYIHEtsikpillkkFLRFCINKC----ASET-IFVSNY---LFETEKLENItN 168
Cdd:cd03823    99 VVHTHnlsgLGASLLDAARDLGIPVVHTLHD----------YWLLCPRQFlfkkGGDAvLAPSRFtanLHEANGLFSA-R 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 169 QYVIynplSNSLITPIDELDIDAKYHGR-NVLFLSSLVPYKGLDDFLAIAKMAivKSQDINFHMVLNCSvtqfnsFLKER 247
Cdd:cd03823   168 ISVI----PNAVEPDLAPPPRRRPGTERlRFGYIGRLTEEKGIDLLVEAFKRL--PREDIELVIAGHGP------LSDER 235

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539298845 248 EIPRNVTMYN----RPKNLRGLYQMSSFVLNLSTpeWIETFGLTLVEGMANGAIPIGPVTGGPAEIIK 311
Cdd:cd03823   236 QIEGGRRIAFlgrvPTDDIKDFYEKIDVLVVPSI--WPEPFGLVVREAIAAGLPVIASDLGGIAELIQ 301
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 22-311 3.91e-09

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 56.86  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  22 GSPRVLREMISTVSSEKH---LITSDGEGVLS--DID-GVEYHQFRYIPNSNKFVKLYQFVVanIIIFHMLYRLLKANkg 95
Cdd:cd03820    14 GAERVAINLANHLAKKGYdvtIISLDSAEKPPfyELDdNIKIKNLGDRKYSHFKLLLKYFKK--VRRLRKYLKNNKPD-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  96 qeqhVIVNTMLPFGAMFAARIMKVRTTVYIHETSI--KPILLKKFLRFCINKCASETIFVSN-YLFETEKLENiTNQYVI 172
Cdd:cd03820    90 ----VVISFRTSLLTFLALIGLKSKLIVWEHNNYEayNKGLRRLLLRRLLYKRADKIVVLTEaDKLKKYKQPN-SNVVVI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 173 YNPLSNSLITPIDELDidakyhGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMVLNCSV-TQFNSFLKEREIPR 251
Cdd:cd03820   165 PNPLSFPSEEPSTNLK------SKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPErEELEKLIDKLGLED 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1539298845 252 NVTMYNRPKNLRGLYQMSS-FVLnlstPEWIETFGLTLVEGMANGAIPIG---PVtgGPAEIIK 311
Cdd:cd03820   239 RVKLLGPTKNIAEEYANSSiFVL----SSRYEGFPMVLLEAMAYGLPIISfdcPT--GPSEIIE 296
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 194-310 5.58e-09

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 55.87  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 194 HGRNVLFLSSLVPYKGLDDFLAIAKMAiVKSQDINFHMVLNCS-----VTQFNSFLKEREIPRNVTMYNRPKNLRGLYQM 268
Cdd:cd01635   109 PLADKVSVGRLVPEKGIDLLLEALALL-KARLPDLVLVLVGGGgereeEEALAAALGLLERVVIIGGLVDDEVLELLLAA 187

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1539298845 269 SSFVLNLStpeWIETFGLTLVEGMANGAIPIGPVTGGPAEII 310
Cdd:cd01635   188 ADVFVLPS---RSEGFGLVLLEAMAAGKPVIATDVGGIPEFV 226
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 25-296 1.09e-08

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 55.83  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  25 RVLREMIstvsseKHLITSDGEgvlsdidgVEYHQFRYIPNSNKFVKLYQFVVANIIIFHMLYRLLKANKGQEQHVIVNT 104
Cdd:cd03809    18 RYTRELL------KALAKNDPD--------ESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLPKKD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 105 M--LPFGAMFAA--RIMKVRTTVYIH----------ETSIKPILLKKFLRFCInKCASETIFVSNY----LFET--EKLE 164
Cdd:cd03809    84 KpdLLHSPHNTAplLLKGCPQVVTIHdliplrypefFPKRFRLYYRLLLPISL-RRADAIITVSEAtrddIIKFygVPPE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 165 NITnqyVIYNPLSNSLITPIDELDIDAKY--HGRNVLFLSSLVPYKGLDDFLAIAKMAivKSQDINFHMVLNCS----VT 238
Cdd:cd03809   163 KIV---VIPLGVDPSFFPPESAAVLIAKYllPEPYFLYVGTLEPRKNHERLLKAFALL--KKQGGDLKLVIVGGkgweDE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 239 QFNSFLKEREIPRNVTMYNRP--KNLRGLYQMSSFVLNLStpeWIETFGLTLVEGMANGA 296
Cdd:cd03809   238 ELLDLVKKLGLGGRVRFLGYVsdEDLPALYRGARAFVFPS---LYEGFGLPVLEAMACGT 294
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
195-310 9.31e-08

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 50.20  E-value: 9.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 195 GRNVLFLSSLVP-YKGLDDFLAIakMAIVKSQDINFHMVL--NCSVTQFNSflKEREIPRNVTMYNRPKNLRGLYQMSS- 270
Cdd:pfam13692   1 RPVILFVGRLHPnVKGVDYLLEA--VPLLRKRDNDVRLVIvgDGPEEELEE--LAAGLEDRVIFTGFVEDLAELLAAADv 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1539298845 271 FVLnlstPEWIETFGLTLVEGMANGaIPIgpVT---GGPAEII 310
Cdd:pfam13692  77 FVL----PSLYEGFGLKLLEAMAAG-LPV--VAtdvGGIPELV 112
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 22-311 5.16e-06

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 47.35  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  22 GSPRVLREMISTVSSEKH---LITSDGEGVLSDIDGVEYHQFRYipnsnKFVKLYQFVVANIIIFHMLYRLLKANKGQeq 98
Cdd:cd03811    13 GAERVLLNLANALDKRGYdvtLVLLRDEGDLDKQLNGDVKLIRL-----LIRVLKLIKLGLLKAILKLKRILKRAKPD-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  99 hVIVNTMLPFGAMFAArIMKVRTTVYIHETSI---------KPILLKKFLRFCiNK--CASETI---FVSNYLFETEKLE 164
Cdd:cd03811    86 -VVISFLGFATYIVAK-LAAARSKVIAWIHSSlsklyylkkKLLLKLKLYKKA-DKivCVSKGIkedLIRLGPSPPEKIE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 165 nitnqyVIYNPLSNSLITPIDELDIDAKY-HGRNVLFLSSLVPYKGLDDFLAIAKMAIVKSQDINFHMV--------LNC 235
Cdd:cd03811   163 ------VIYNPIDIDRIRALAKEPILNEPeDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILgdgplreeLEK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1539298845 236 SVTQFNsfLKEReiprnVTMYNRPKNLRGLYQMSS-FVLNLSTpewiETFGLTLVEGMANGAIPIGPVTGGPAEIIK 311
Cdd:cd03811   237 LAKELG--LAER-----VIFLGFQSNPYPYLKKADlFVLSSRY----EGFPNVLLEAMALGTPVVSTDCPGPREILD 302
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 262-319 1.26e-04

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 41.13  E-value: 1.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539298845 262 LRGLYQMSSFVLNlstPEWIETFGLTLVEGMANGAIPIGPVTGGPAEIIKSAFWLYYI 319
Cdd:COG0438    14 LEALLAAADVFVL---PSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLV 68
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 153-311 1.52e-04

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 43.06  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 153 VSNYLFETE-KLENITNQYVIYNPLSNSLITPIDELDIDAKYHGRN---VLFLSSLVPYKGLDDFLAIAKMAIVKSQDIN 228
Cdd:cd04949   114 YDAIIVSTEqQKQDLSERFNKYPPIFTIPVGYVDQLDTAESNHERKsnkIITISRLAPEKQLDHLIEAVAKAVKKVPEIT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 229 FHMVLNCSV-TQFNSFLKEREIPRNVTMYNRPKNLRGLYQMSSFVLNLSTpewIETFGLTLVEGMANGAIPIG-PVTGGP 306
Cdd:cd04949   194 LDIYGYGEErEKLKKLIEELHLEDNVFLKGYHSNLDQEYQDAYLSLLTSQ---MEGFGLTLMEAIGHGLPVVSyDVKYGP 270


                  ....*
gi 1539298845 307 AEIIK 311
Cdd:cd04949   271 SELIE 275
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 134-295 2.85e-04

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 42.26  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 134 LLKKFLRFCINKcaSETIFVS--NYLFETEKLENITNQYVIYnPLS-NSLITPIDELDIDAKYH----GRNVLFLSSLVP 206
Cdd:cd03795   126 LYKPLMTRFLRR--ADRIIATspNYVETSPTLREFKNKVRVI-PLGiDKNVYNIPRVDFENIKRekkgKKIFLFIGRLVY 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 207 YKGLDDFLAIAkmaivksQDINFHMVLNCSVTQFNSFLKEREI--PRNVTMYNR--PKNLRGLYQMSsFVLNLSTPEWIE 282
Cdd:cd03795   203 YKGLDYLIEAA-------QYLNYPIVIGGEGPLKPDLEAQIELnlLDNVKFLGRvdDEEKVIYLHLC-DVFVFPSVLRSE 274

                         170
                  ....*....|...
gi 1539298845 283 TFGLTLVEGMANG 295
Cdd:cd03795   275 AFGIVLLEAMMCG 287
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 55-295 3.44e-04

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 41.88  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845  55 VEYHqfRYIPNSNKFVKLYQFVVAnIIIFHMLYRLLKANKGQeqhvIVNTMLPFG----AMFAARIMK---VRTT----- 122
Cdd:cd03817    48 EEVV--RYRSFSIPIRKYHRQHIP-FPFKKAVIDRIKELGPD----IIHTHTPFSlgklGLRIARKLKipiVHTYhtmye 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 123 VYIHETS----IKPILLKKFLRFCINKCaSETIFVSNYLFETEKLENIT-NQYVIYNPLSNSLITPIDELDIDAKYHGRN 197
Cdd:cd03817   121 DYLHYIPkgklLVKAVVRKLVRRFYNHT-DAVIAPSEKIKDTLREYGVKgPIEVIPNGIDLDKFEKPLNTEERRKLGLPP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 198 ----VLFLSSLVPYKGLDDFLAIAKMaIVKSQDINFHMV---------------LNCS-VTQFNSFLKEREIPrnvtmyn 257
Cdd:cd03817   200 depiLLYVGRLAKEKNIDFLLRAFAE-LKKEPNIKLVIVgdgpereelkelareLGLAdKVIFTGFVPREELP------- 271

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1539298845 258 rpknlrGLYQMSSFVLNLSTpewIETFGLTLVEGMANG 295
Cdd:cd03817   272 ------EYYKAADLFVFAST---TETQGLVYLEAMAAG 300
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 194-312 3.64e-04

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 41.84  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 194 HGRNVLFLSSLVPYKGLDDFL-AIAKMAIVKsQDINFHMVLNCS--VTQFNSFLKER--EIPRNVTMYNRPKNLR----- 263
Cdd:cd03800   219 DKPVVLALGRLDPRKGIDTLVrAFAQLPELR-ELANLVLVGGPSddPLSMDREELAElaEELGLIDRVRFPGRVSrddlp 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1539298845 264 GLYQMSSFVLNlstPEWIETFGLTLVEGMANGAIPIGPVTGGPAEIIKS 312
Cdd:cd03800   298 ELYRAADVFVV---PSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRD 343
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 171-312 1.51e-03

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 40.01  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539298845 171 VIYNPLSNSLITPIDELDIDAKY----HGRNVLFLSSLV--PYKGLDDFLAiAKMAIVKSQDINFHMVLNCSVTQFNSFL 244
Cdd:cd03825   165 VIPNGIDTEIFAPVDKAKARKRLgipqDKKVILFGAESVtkPRKGFDELIE-ALKLLATKDDLLLVVFGKNDPQIVILPF 243

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539298845 245 KEREIPR--NVTmynrpkNLRGLY-QMSSFVLnlstPEWIETFGLTLVEGMANGAIPIGPVTGGPAEIIKS 312
Cdd:cd03825   244 DIISLGYidDDE------QLVDIYsAADLFVH----PSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQH 304
PLN00142 PLN00142
sucrose synthase
 278-314 8.79e-03

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 37.65  E-value: 8.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1539298845 278 PEWIETFGLTLVEGMANGAIPIGPVTGGPAEII---KSAF 314
Cdd:PLN00142  673 PALYEAFGLTVVEAMTCGLPTFATCQGGPAEIIvdgVSGF 712
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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