|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
9-407 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 538.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 9 LRSVDVMLEELLSKAKPAkESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPTSLKISQRIPAGS 88
Cdd:COG0303 1 MISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANPVTLRVVGEIAAGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 89 VP-HPLQTGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLM 167
Cdd:COG0303 80 PPpGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 168 ASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAA 247
Cdd:COG0303 160 ASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 248 DIIITSGGVSVGEEDHIKAAITKLG-ELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAE 326
Cdd:COG0303 240 DLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 327 RIEAHSFKLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSSGVLSSASWADGFAVIPEHTTP-QQGELVEFWPFS 405
Cdd:COG0303 320 PPPPPRVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGvEAGEEVEVLLLD 399
|
..
gi 2359305436 406 EL 407
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
16-404 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 513.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 16 LEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGePTSLKISQRIPAGSVPH-PLQ 94
Cdd:cd00887 4 ARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGA-SVTLRVVGEIPAGEPPDgPLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 95 TGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMASIGIAN 174
Cdd:cd00887 83 PGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 175 INIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSG 254
Cdd:cd00887 163 VPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 255 GVSVGEEDHIKAAITKL-GELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAERIEAHSF 333
Cdd:cd00887 243 GVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRV 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2359305436 334 KLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSSGVLSSASWADGFAVIPEHTTP-QQGELVEFWPF 404
Cdd:cd00887 323 KARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGlEAGEEVEVLLL 394
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
3-407 |
6.76e-135 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 399.37 E-value: 6.76e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 3 CCDRGQLR--SVDVMLEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCqggEPTSLKI 80
Cdd:PRK14491 190 CCDLLSPAflSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDL---EPESYTL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 81 SQRIPAG-SVPHPLQTGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRI 159
Cdd:PRK14491 267 VGEVLAGhQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRL 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 160 RAQDMGLMASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTA 239
Cdd:PRK14491 347 SAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEAT 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 240 LNEAAEAADIIITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFL 319
Cdd:PRK14491 427 LEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPAL 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 320 LKSQGAERIEAHSFKLPIGFSLKKPGKRREYLRTRLSYNQ-GSASIENHPNQSSGVLSSASWADGFAVI-PEHTTPQQGE 397
Cdd:PRK14491 507 RKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGAdGRLHVRTTGKQGSGILSSMSEANCLIEIgPAAETVNAGE 586
|
410
....*....|
gi 2359305436 398 LVEFWPFSEL 407
Cdd:PRK14491 587 TVTIQPLAGL 596
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
24-171 |
1.20e-52 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 172.37 E-value: 1.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 24 KPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPTSlkisqRIPAGSVPHPLQT-GTAARIF 102
Cdd:pfam03453 3 LGTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVN-----PIAAGEPPGPLLPgGEAVRIM 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 103 TGATIPPNATAVVMQEDCTEQDG-TVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMASIG 171
Cdd:pfam03453 78 TGAPLPEGADAVVMVEDTEEGGGrTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
181-317 |
1.08e-39 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 138.99 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 181 LKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGGVSVGE 260
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2359305436 261 EDHIKAAITKLGE-----------LDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARP 317
Cdd:TIGR00177 81 RDVTPEALEELGEkeipgfgefrmLSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
184-311 |
6.25e-37 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 131.17 E-value: 6.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 184 AILSTGDELVEPGevakegQIYNSNRYTLKGLLDGFGFEIVDVGIV--EDTLNATLTALNEAAEAADIIITSGGVSVGEE 261
Cdd:smart00852 1 AIISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2359305436 262 DHIKAAITKLG--ELDLWKLAIKPGKPFAY---------GQVGNTPILGLPGNPGAVFVTF 311
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMF 135
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
9-407 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 538.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 9 LRSVDVMLEELLSKAKPAkESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPTSLKISQRIPAGS 88
Cdd:COG0303 1 MISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANPVTLRVVGEIAAGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 89 VP-HPLQTGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLM 167
Cdd:COG0303 80 PPpGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 168 ASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAA 247
Cdd:COG0303 160 ASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 248 DIIITSGGVSVGEEDHIKAAITKLG-ELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAE 326
Cdd:COG0303 240 DLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 327 RIEAHSFKLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSSGVLSSASWADGFAVIPEHTTP-QQGELVEFWPFS 405
Cdd:COG0303 320 PPPPPRVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGvEAGEEVEVLLLD 399
|
..
gi 2359305436 406 EL 407
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
16-404 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 513.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 16 LEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGePTSLKISQRIPAGSVPH-PLQ 94
Cdd:cd00887 4 ARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGA-SVTLRVVGEIPAGEPPDgPLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 95 TGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMASIGIAN 174
Cdd:cd00887 83 PGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 175 INIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSG 254
Cdd:cd00887 163 VPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 255 GVSVGEEDHIKAAITKL-GELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAERIEAHSF 333
Cdd:cd00887 243 GVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRV 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2359305436 334 KLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSSGVLSSASWADGFAVIPEHTTP-QQGELVEFWPF 404
Cdd:cd00887 323 KARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGlEAGEEVEVLLL 394
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
3-407 |
6.76e-135 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 399.37 E-value: 6.76e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 3 CCDRGQLR--SVDVMLEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCqggEPTSLKI 80
Cdd:PRK14491 190 CCDLLSPAflSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDL---EPESYTL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 81 SQRIPAG-SVPHPLQTGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRI 159
Cdd:PRK14491 267 VGEVLAGhQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRL 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 160 RAQDMGLMASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTA 239
Cdd:PRK14491 347 SAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEAT 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 240 LNEAAEAADIIITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFL 319
Cdd:PRK14491 427 LEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPAL 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 320 LKSQGAERIEAHSFKLPIGFSLKKPGKRREYLRTRLSYNQ-GSASIENHPNQSSGVLSSASWADGFAVI-PEHTTPQQGE 397
Cdd:PRK14491 507 RKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGAdGRLHVRTTGKQGSGILSSMSEANCLIEIgPAAETVNAGE 586
|
410
....*....|
gi 2359305436 398 LVEFWPFSEL 407
Cdd:PRK14491 587 TVTIQPLAGL 596
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
9-410 |
3.15e-106 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 319.73 E-value: 3.15e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 9 LRSVDVMLEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPtsLKISQRIPAGS 88
Cdd:PRK10680 7 LMSLETALTEMLSRVTPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQP--LPVAGKAFAGQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 89 vphPLQ----TGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDM 164
Cdd:PRK10680 85 ---PFHgewpAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 165 GLMASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAA 244
Cdd:PRK10680 162 PVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIEAD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 245 EAADIIITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQG 324
Cdd:PRK10680 242 SQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 325 aerieAHSFKLPI------GFSLKKPGKRREYLRTRLSYN-QGSASIENHPNQSSGVLSSASWADGFAVIP-EHTTPQQG 396
Cdd:PRK10680 322 -----NTASGLPPrqrvrtASRLKKTPGRLDFQRGILQRNaDGELEVTTTGHQGSHIFSSFSLGNCFIVLErERGNVEVG 396
|
410
....*....|....
gi 2359305436 397 ELVEFWPFSELFGN 410
Cdd:PRK10680 397 EWVEVEPFNALFGG 410
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
15-410 |
3.52e-99 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 308.30 E-value: 3.52e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 15 MLEELLSKAKPAKESIniAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQG---GEPTSLKISQRIPAGSVPH 91
Cdd:PRK14498 18 ILESLLSELPLGTEEV--PLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGaseANPVRLKLGGEVHAGEAPD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 92 -PLQTGTAARIFTGATIPPNATAVVMQEDCTEQD-GTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMAS 169
Cdd:PRK14498 96 vEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAGELILPKGTRLTPRDIGALAA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 170 IGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADI 249
Cdd:PRK14498 176 GGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRKALKECDL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 250 IITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAERIE 329
Cdd:PRK14498 256 VLLSGGTSAGAGDVTYRVIEELGEVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLAGLPPPE 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 330 AHSFKLPIGFSLKKPGKRREYLrtRLSYNQGSASIENHP-NQSSGVLSSASWADGFAVIPEHT-TPQQGELVEFwpfsEL 407
Cdd:PRK14498 336 RATVKARLARRVRSELGREEFV--PVSLGRVGDGYVAYPlSRGSGAITSLVRADGFIEIPANTeGLEAGEEVEV----EL 409
|
...
gi 2359305436 408 FGN 410
Cdd:PRK14498 410 FGP 412
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
12-404 |
2.49e-95 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 291.82 E-value: 2.49e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 12 VDVMLEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPTSLkISQRIPAGsVPH 91
Cdd:PRK14690 25 VDTALDLLRARLGPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPEGAQVLPL-IEGRAAAG-VPF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 92 P--LQTGTAARIFTGATIPPNATAVVMQEDCTEQDGTVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMAS 169
Cdd:PRK14690 103 SgrVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 170 IGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADI 249
Cdd:PRK14690 183 VGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAAEADV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 250 IITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLKSQGAERIE 329
Cdd:PRK14690 263 ILTSGGASAGDEDHVSALLREAGAMQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEGWSE 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2359305436 330 AHSFKLPIGFSLKKPGKRREYLRTRLSynQGSAsiENHPNQSSGVLSSASWADGFAVIPE---HTTPqqGELVEFWPF 404
Cdd:PRK14690 343 PQGFTVPAAFEKRKKPGRREYLRARLR--QGHA--EVFRSEGSGRISGLSWAEGLVELGDgarRIAP--GDPVRFIPY 414
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
9-400 |
2.34e-68 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 225.84 E-value: 2.34e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 9 LRSVDVMLEELLSKAKPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCqggePTSLKISQRIPAGS 88
Cdd:PRK14497 10 LYSIDEAIKVFLSSLNFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSSCT----PGEFKVIDKIGIGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 89 VPH-PLQTGTAARIFTGATIPPNATAVVMQEDCTEQDGT-VTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGL 166
Cdd:PRK14497 86 FKEiHIKECEAVEVDTGSMIPMGADAVIKVENTKVINGNfIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIGL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 167 MASIGIANINIYRPLKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEA 246
Cdd:PRK14497 166 LASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 247 ADIIITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFL--LKSQG 324
Cdd:PRK14497 246 ADVLILTGGTSAGEKDFVHQAIRELGNIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLksLYPSR 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2359305436 325 AERIEAHSFKLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSS--GVLSSaswADGFAVIPEHTTPQQGELVE 400
Cdd:PRK14497 326 KEILGLGKIKARLALRVKADEHRNTLIPVYLFKSDNSYYALPVPFDSYmvGTFSL---TDGYIMLGPNEEIEEGKEVE 400
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
4-317 |
7.57e-57 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 197.73 E-value: 7.57e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 4 CDRGQLRSVDVMLEELLSKAKPAkESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPtsLKISQR 83
Cdd:PLN02699 2 GGKTEMISVEEALSIVLSVAARL-SPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGPGEYP--VITESR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 84 IPAGSVPHPLQTGTAARIFTGATIPPNATAVVMQED-CTEQDG-----TVTLPTNINLNQNIRPQGQDIKSNQVILKRGH 157
Cdd:PLN02699 79 AGNDGLGVTLTPGTVAYVTTGGPIPDGADAVVQVEDtEVVEDPldgskRVRILSQASKGQDIRPVGCDIEKDAKVLKAGE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 158 RIRAQDMGLMASIGIANINIYRPLKVAILSTGDELVEPGE-VAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNAT 236
Cdd:PLN02699 159 RLGASEIGLLATVGVTMVKVYPRPTVAILSTGDELVEPTTgTLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEEL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 237 LTALNEA-AEAADIIITSGGVSVGEEDHIKAAITKLGELDLWKLAIKPGKPFAYGQVGNTP---------ILGLPGNPGA 306
Cdd:PLN02699 239 ERILDEAiSSGVDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIDAKSapsnskkmlAFGLPGNPVS 318
|
330
....*....|.
gi 2359305436 307 VFVTFCILARP 317
Cdd:PLN02699 319 CLVCFNLFVVP 329
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
24-171 |
1.20e-52 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 172.37 E-value: 1.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 24 KPAKESINIAVADALGRVLAEDVVSSINVPPYDNSAVDGYAVIADNCQGGEPTSlkisqRIPAGSVPHPLQT-GTAARIF 102
Cdd:pfam03453 3 LGTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVN-----PIAAGEPPGPLLPgGEAVRIM 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 103 TGATIPPNATAVVMQEDCTEQDG-TVTLPTNINLNQNIRPQGQDIKSNQVILKRGHRIRAQDMGLMASIG 171
Cdd:pfam03453 78 TGAPLPEGADAVVMVEDTEEGGGrTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
181-317 |
1.08e-39 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 138.99 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 181 LKVAILSTGDELVEPGEVAKEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGGVSVGE 260
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2359305436 261 EDHIKAAITKLGE-----------LDLWKLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARP 317
Cdd:TIGR00177 81 RDVTPEALEELGEkeipgfgefrmLSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
184-311 |
6.25e-37 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 131.17 E-value: 6.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 184 AILSTGDELVEPGevakegQIYNSNRYTLKGLLDGFGFEIVDVGIV--EDTLNATLTALNEAAEAADIIITSGGVSVGEE 261
Cdd:smart00852 1 AIISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2359305436 262 DHIKAAITKLG--ELDLWKLAIKPGKPFAY---------GQVGNTPILGLPGNPGAVFVTF 311
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMF 135
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
184-321 |
2.61e-35 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 126.98 E-value: 2.61e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 184 AILSTGDELVEpgevakeGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGGVSVGEEDH 263
Cdd:pfam00994 1 AIITTGDELLP-------GQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDV 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 264 IKAAITKLGELDL-------WKLAIKPGKP-----FAYGQVGNTPILGLPGNPGAVFVTFCILARPFLLK 321
Cdd:pfam00994 74 TPEALAELGGRELpgfeelfRGVSLKPGKPvgtapGAILSRAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
182-319 |
1.82e-28 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 108.58 E-value: 1.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 182 KVAILSTGDELVEpgevakeGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGGVSVGEE 261
Cdd:cd00758 1 RVAIVTVSDELSQ-------GQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRR 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 262 DHIKAAITKLGELDLW--KLAIKPGKPFAYGQVGNTPILGLPGNPGAVFVTFCILARPFL 319
Cdd:cd00758 74 DVTPEALAELGEREAHgkGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
334-404 |
2.19e-15 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 70.33 E-value: 2.19e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2359305436 334 KLPIGFSLKKPGKRREYLRTRLSYNQGSASIENHPNQSSGVLSSASWADGFAVIPEHTTP-QQGELVEFWPF 404
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLHEEDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGlEAGEEVEVILL 72
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
178-302 |
2.36e-11 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 64.10 E-value: 2.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 178 YRPLKVAILSTGDELVEPGEVAKEGQIynsnrytLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEA-ADIIITSGGV 256
Cdd:cd03522 157 FRPLRVGLIVTGSEVYGGRIEDKFGPV-------LRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAgAELLILTGGA 229
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2359305436 257 SVGEEDHIKAAITKLG-ELDLWKLAIKPGKPFAYGQVGNTPILGLPG 302
Cdd:cd03522 230 SVDPDDVTPAAIRAAGgEVIRYGMPVDPGNLLLLGYLGGVPVIGLPG 276
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
182-255 |
8.90e-08 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 51.72 E-value: 8.90e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2359305436 182 KVAILSTGDELVEpgevakeGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGG 255
Cdd:cd00885 1 TAEIIAIGDELLS-------GQIVDTNAAFLAKELAELGIEVYRVTVVGDDEDRIAEALRRASERADLVITTGG 67
|
|
| MoaB |
COG0521 |
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ... |
179-307 |
2.48e-07 |
|
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440287 [Multi-domain] Cd Length: 169 Bit Score: 50.12 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 179 RPLKVAILSTGDELVEPGEVAKEGQIynsnrytLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAA--EAADIIITSGGV 256
Cdd:COG0521 8 VPLRIAVLTVSDRRSRGEREDTSGPA-------LVELLEEAGHEVVARRIVPDDKDAIRAALRELIddEGVDLVLTTGGT 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2359305436 257 SVGEEDH----IKAAITK----LGELdLWKLAIKPGKPFAY------GQVGNTPILGLPGNPGAV 307
Cdd:COG0521 81 GLSPRDVtpeaTRPLLDKelpgFGEL-FRALSLEEIGPSAIlsravaGIRGGTLIFNLPGSPGAV 144
|
|
| MogA_MoaB |
cd00886 |
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ... |
212-307 |
2.17e-05 |
|
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.
Pssm-ID: 238451 [Multi-domain] Cd Length: 152 Bit Score: 44.39 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 212 LKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEA--ADIIITSGGVSVGEEDH----IKAAITK----LGELdLWKLAI 281
Cdd:cd00886 25 LVELLEEAGHEVVAYEIVPDDKDEIREALIEWADEdgVDLILTTGGTGLAPRDVtpeaTRPLLDKelpgFGEA-FRALSL 103
|
90 100 110
....*....|....*....|....*....|..
gi 2359305436 282 KPGkPFAY------GQVGNTPILGLPGNPGAV 307
Cdd:cd00886 104 EET-GTAMlsravaGIRGGTLIFNLPGSPKAV 134
|
|
| PRK03673 |
PRK03673 |
nicotinamide mononucleotide deamidase-related protein YfaY; |
181-273 |
6.84e-05 |
|
nicotinamide mononucleotide deamidase-related protein YfaY;
Pssm-ID: 179629 [Multi-domain] Cd Length: 396 Bit Score: 44.69 E-value: 6.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 181 LKVAILSTGDELVepgevakEGQIYNSNRYTLKGLLDGFGFEIVDVGIVEDTLNATLTALNEAAEAADIIITSGGVSVGE 260
Cdd:PRK03673 2 LRVEMLSTGDEVL-------HGQIVDTNAAWLADFFFHQGLPLSRRNTVGDNLDALVAILRERSQHADVLIVNGGLGPTS 74
|
90
....*....|....
gi 2359305436 261 ED-HIKAAITKLGE 273
Cdd:PRK03673 75 DDlSALAAATAAGE 88
|
|
| moaC |
PRK03604 |
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional |
211-307 |
1.79e-04 |
|
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
Pssm-ID: 235138 [Multi-domain] Cd Length: 312 Bit Score: 43.01 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2359305436 211 TLKGLLDGFGFEIVDVGIVED---TLNATLTALneAAEAADIIITSGGVSVGEEDHIKAAITKLGELDLwklaikPG--- 284
Cdd:PRK03604 179 LIVEGLEEAGFEVSHYTIIPDepaEIAAAVAAW--IAEGYALIITTGGTGLGPRDVTPEALAPLLERRL------PGiae 250
|
90 100 110
....*....|....*....|....*....|....*...
gi 2359305436 285 KPFAYGQ---------------VGNTPILGLPGNPGAV 307
Cdd:PRK03604 251 ALRSWGQgrtptamlsrlvagmIGNSLVVALPGSPGGA 288
|
|
| |
