NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2304866575|gb|UWZ49044|]
View 

anti-sigma regulatory factor [Dactylosporangium matsuzakiense]

Protein Classification

ATP-binding protein( domain architecture ID 382)

ATP-binding protein containing histidine kinase-like ATPase domain, similar to Streptomyces subrutilus DNA gyrase an an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 33-135 1.65e-24

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16934:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 117  Bit Score: 90.51  E-value: 1.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2304866575  33 EAKLPLVDQTKLVTAASELARNTLIHGGGGYATIAGVHNGRRAGVRAEFVDSGPGIVDLGLAFTDGYTTGSGLGLGLSGS 112
Cdd:cd16934    15 RLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDGFSTGGGLGLGLGGV 94

                          90       100
                  ....*....|....*....|...
gi 2304866575 113 RRLVDEFEIDTTPGAGTRIAVTK 135
Cdd:cd16934    95 RRLADEFDLHSAPGRGTVVVARK 117
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 33-135 1.65e-24

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 90.51  E-value: 1.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2304866575  33 EAKLPLVDQTKLVTAASELARNTLIHGGGGYATIAGVHNGRRAGVRAEFVDSGPGIVDLGLAFTDGYTTGSGLGLGLSGS 112
Cdd:cd16934    15 RLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDGFSTGGGLGLGLGGV 94

                          90       100
                  ....*....|....*....|...
gi 2304866575 113 RRLVDEFEIDTTPGAGTRIAVTK 135
Cdd:cd16934    95 RRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
33-136 9.91e-09

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 50.30  E-value: 9.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2304866575  33 EAKLPLVDQTKLVTAASELARNTLIHGGGGYAT-----IAGVHNGRragVRAEFVDSGPGIVDLGLAftDGYTTGSGLGL 107
Cdd:COG2172    24 ELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPDgpvevELELDPDG---LEIEVRDEGPGFDPEDLP--DPYSTLAEGGR 98

                          90       100
                  ....*....|....*....|....*....
gi 2304866575 108 GLSGSRRLVDEFEIDTTPGaGTRIAVTKW 136
Cdd:COG2172    99 GLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 33-135 1.65e-24

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 90.51  E-value: 1.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2304866575  33 EAKLPLVDQTKLVTAASELARNTLIHGGGGYATIAGVHNGRRAGVRAEFVDSGPGIVDLGLAFTDGYTTGSGLGLGLSGS 112
Cdd:cd16934    15 RLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDGFSTGGGLGLGLGGV 94

                          90       100
                  ....*....|....*....|...
gi 2304866575 113 RRLVDEFEIDTTPGAGTRIAVTK 135
Cdd:cd16934    95 RRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
33-136 9.91e-09

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 50.30  E-value: 9.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2304866575  33 EAKLPLVDQTKLVTAASELARNTLIHGGGGYAT-----IAGVHNGRragVRAEFVDSGPGIVDLGLAftDGYTTGSGLGL 107
Cdd:COG2172    24 ELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPDgpvevELELDPDG---LEIEVRDEGPGFDPEDLP--DPYSTLAEGGR 98

                          90       100
                  ....*....|....*....|....*....
gi 2304866575 108 GLSGSRRLVDEFEIDTTPGaGTRIAVTKW 136
Cdd:COG2172    99 GLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH