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Conserved domains on  [gi|2260484600|gb|USS86673|]
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phosphomevalonate kinase [Fructilactobacillus cliffordii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pmev_kin_Gr_pos super family cl31078
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
 2-355 9.39e-140

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


The actual alignment was detected with superfamily member TIGR01220:

Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 400.82  E-value: 9.39e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   2 IKTSTPGKLYLAGEYAVVENGNPAIIAAVNRFVTVTIDENTDRC-SITSKQYENHLVHWERINSRMVVDDRD--NPFQYI 78
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAAdVIISSDLGPQPVGWRRHDGRLVVRDPDarSALAYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  79 IAAIQVTEDYVQALGKPTQKYHLSVNSDLDSGTGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGN 158
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 159 GSLGDVASSVFGGLITYCSFDRQWLSEFLHKITLPELLKLEWPRLEITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKK 238
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 239 GKHGIHYERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSQMAGVPIETPQLTRLIEIAEQFGGVAKTSGAG 318
Cdd:TIGR01220 241 WRGSASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2260484600 319 GGDCGIVLIKSDCDIAGLKAAWREADIEPLDLSIYNY 355
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLE 357
 
Name Accession Description Interval E-value
Pmev_kin_Gr_pos TIGR01220
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
 2-355 9.39e-140

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 400.82  E-value: 9.39e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   2 IKTSTPGKLYLAGEYAVVENGNPAIIAAVNRFVTVTIDENTDRC-SITSKQYENHLVHWERINSRMVVDDRD--NPFQYI 78
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAAdVIISSDLGPQPVGWRRHDGRLVVRDPDarSALAYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  79 IAAIQVTEDYVQALGKPTQKYHLSVNSDLDSGTGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGN 158
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 159 GSLGDVASSVFGGLITYCSFDRQWLSEFLHKITLPELLKLEWPRLEITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKK 238
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 239 GKHGIHYERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSQMAGVPIETPQLTRLIEIAEQFGGVAKTSGAG 318
Cdd:TIGR01220 241 WRGSASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2260484600 319 GGDCGIVLIKSDCDIAGLKAAWREADIEPLDLSIYNY 355
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLE 357
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 6-326 1.60e-97

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 290.21  E-value: 1.60e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   6 TPGKLYLAGEYAVVEnGNPAIIAAVNRFVTVTIDE-NTDRCSITSKQYEnhlVHWERinsrmvVDDRDNPFQYIIAAIQV 84
Cdd:COG1577     1 APGKLILFGEHAVVY-GQPAIAVAVDRRATVTVEPsDDDKLRIESPDLG---GTLDL------DPLADAALRYIKAAIEA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  85 TEDYvqaLGKPTQKYHLSVNSDLdsgtGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGNGSLGDV 164
Cdd:COG1577    71 ALEY---LGLPLKGFDIEIDSEI----PRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGLDT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 165 ASSVFGGLITYCSFDRqwlseflhkitlpellklewprleITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKKGKHGIH 244
Cdd:COG1577   144 AASTYGGPIYYQRGDR------------------------AEPLELPKNLPLVVGDTGVPASTKELVAKVRKLKERNPEL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 245 YERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSqmagvpIETPQLTRLIEIAEQFGG-VAKTSGAGGGDCG 323
Cdd:COG1577   200 YEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRALG------VSTPELDRLVEAARKAGAlGAKLTGAGGGGCV 273


                  ...
gi 2260484600 324 IVL 326
Cdd:COG1577   274 IAL 276
PRK03926 PRK03926
mevalonate kinase; Provisional
 1-330 1.78e-34

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 128.25  E-value: 1.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   1 MIKTSTPGKLYLAGEYAVVEnGNPAIIAAVNRFVTVTIDENTDRCSITS---KQYENHLvhwerinsrmvvddrdnpfqY 77
Cdd:PRK03926    1 MVLCSAPGKIYLFGEHAVVY-GKPAIACAIDLRTYVRAEFNDDSIYIESdygKTGEKHP--------------------Y 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  78 IIAAIQVTEDYVqalgkPTQKYHLSVNSDLDSGTGkkygLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQG 157
Cdd:PRK03926   60 VSAAIEKMREEA-----DKDGVTVSITSQIPVGSG----LGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQG 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 158 NGSLGDVASSVFGGLITYcsfdrqwlseflhkitlPELLKLEWPRLEItplqippvlrfLVGWTGSPASTSQLIDKVELK 237
Cdd:PRK03926  131 AASPTDTYVSTMGGFVTI-----------------PDRKKLPFPECGI-----------VVGYTGSSGSTKELVANVRKL 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 238 kgkhgihYERFLH----------DSNKCVREITNGFRQNNIRLIMqNIkkNRELLQSLsqmaGVpiETPQLTRLIEIAEQ 307
Cdd:PRK03926  183 -------KEEYPEliepilssigKISEKGEELILSGDYVSLGELM-NI--NQGLLDAL----GV--STKELSELIYAART 246

                         330       340
                  ....*....|....*....|....
gi 2260484600 308 FGGV-AKTSGAGGGDCGIVLIKSD 330
Cdd:PRK03926  247 AGALgAKITGAGGGGCMVALAAPE 270
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 100-171 5.34e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 5.34e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2260484600 100 HLSVNSDLDSGTGkkygLGSSAAVTVATIKALCQLYHLNvskvqLFKLAAIAHFSVQ-GNGSLGDVASSVFGG 171
Cdd:pfam00288   1 DIEIESNIPLGAG----LGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGgGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
Pmev_kin_Gr_pos TIGR01220
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
 2-355 9.39e-140

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 400.82  E-value: 9.39e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   2 IKTSTPGKLYLAGEYAVVENGNPAIIAAVNRFVTVTIDENTDRC-SITSKQYENHLVHWERINSRMVVDDRD--NPFQYI 78
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAAdVIISSDLGPQPVGWRRHDGRLVVRDPDarSALAYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  79 IAAIQVTEDYVQALGKPTQKYHLSVNSDLDSGTGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGN 158
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 159 GSLGDVASSVFGGLITYCSFDRQWLSEFLHKITLPELLKLEWPRLEITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKK 238
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 239 GKHGIHYERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSQMAGVPIETPQLTRLIEIAEQFGGVAKTSGAG 318
Cdd:TIGR01220 241 WRGSASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2260484600 319 GGDCGIVLIKSDCDIAGLKAAWREADIEPLDLSIYNY 355
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLE 357
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 6-326 1.60e-97

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 290.21  E-value: 1.60e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   6 TPGKLYLAGEYAVVEnGNPAIIAAVNRFVTVTIDE-NTDRCSITSKQYEnhlVHWERinsrmvVDDRDNPFQYIIAAIQV 84
Cdd:COG1577     1 APGKLILFGEHAVVY-GQPAIAVAVDRRATVTVEPsDDDKLRIESPDLG---GTLDL------DPLADAALRYIKAAIEA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  85 TEDYvqaLGKPTQKYHLSVNSDLdsgtGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGNGSLGDV 164
Cdd:COG1577    71 ALEY---LGLPLKGFDIEIDSEI----PRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGLDT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 165 ASSVFGGLITYCSFDRqwlseflhkitlpellklewprleITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKKGKHGIH 244
Cdd:COG1577   144 AASTYGGPIYYQRGDR------------------------AEPLELPKNLPLVVGDTGVPASTKELVAKVRKLKERNPEL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 245 YERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSqmagvpIETPQLTRLIEIAEQFGG-VAKTSGAGGGDCG 323
Cdd:COG1577   200 YEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRALG------VSTPELDRLVEAARKAGAlGAKLTGAGGGGCV 273


                  ...
gi 2260484600 324 IVL 326
Cdd:COG1577   274 IAL 276
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 7-326 5.37e-35

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 128.95  E-value: 5.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   7 PGKLYLAGEYAVVeNGNPAIIAAVNRFVTVTIDENTDRCSITSKQYENHLVHwerinsrmvvddrdnPFQYIIAAIQVTe 86
Cdd:TIGR00549   2 PGKIILFGEHAVV-YGEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDD---------------APDELDGLKYVL- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  87 dyVQALGKPTQKYHLSVNSDLDSGTGKKYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGNGSLGDVAS 166
Cdd:TIGR00549  65 --AEFLSRFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTAT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 167 SVFGGLITYCSfdrqwlseflhkitlpellklewpRLEITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKKGKHGIHYE 246
Cdd:TIGR00549 143 STSGGPVYFEK------------------------GEGEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLERFPELID 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 247 RFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSqmagvpIETPQLTRLIEIAEQFG-GVAKTSGAGGGDCGIV 325
Cdd:TIGR00549 199 SIMDAIGELTLEAKAALQDGDVESLGELMNINQGLLKALG------VSHPKLDQLVEIARKAGaLGAKLTGAGGGGCMIA 272


                  .
gi 2260484600 326 L 326
Cdd:TIGR00549 273 L 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 1-330 1.78e-34

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 128.25  E-value: 1.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   1 MIKTSTPGKLYLAGEYAVVEnGNPAIIAAVNRFVTVTIDENTDRCSITS---KQYENHLvhwerinsrmvvddrdnpfqY 77
Cdd:PRK03926    1 MVLCSAPGKIYLFGEHAVVY-GKPAIACAIDLRTYVRAEFNDDSIYIESdygKTGEKHP--------------------Y 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  78 IIAAIQVTEDYVqalgkPTQKYHLSVNSDLDSGTGkkygLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQG 157
Cdd:PRK03926   60 VSAAIEKMREEA-----DKDGVTVSITSQIPVGSG----LGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQG 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 158 NGSLGDVASSVFGGLITYcsfdrqwlseflhkitlPELLKLEWPRLEItplqippvlrfLVGWTGSPASTSQLIDKVELK 237
Cdd:PRK03926  131 AASPTDTYVSTMGGFVTI-----------------PDRKKLPFPECGI-----------VVGYTGSSGSTKELVANVRKL 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 238 kgkhgihYERFLH----------DSNKCVREITNGFRQNNIRLIMqNIkkNRELLQSLsqmaGVpiETPQLTRLIEIAEQ 307
Cdd:PRK03926  183 -------KEEYPEliepilssigKISEKGEELILSGDYVSLGELM-NI--NQGLLDAL----GV--STKELSELIYAART 246

                         330       340
                  ....*....|....*....|....
gi 2260484600 308 FGGV-AKTSGAGGGDCGIVLIKSD 330
Cdd:PRK03926  247 AGALgAKITGAGGGGCMVALAAPE 270
Pmev_kin_ERG8 TIGR01219
phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate ...
 5-351 9.98e-23

phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents plant and fungal forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 273509 [Multi-domain]  Cd Length: 454  Bit Score: 98.48  E-value: 9.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   5 STPGKLYLAGEYAVVENGNPAIIAAVN-RF--VTVTIDE----NTDRCSITSKQYEN----HLVHWE--RINSRMVVDDR 71
Cdd:TIGR01219   3 SAPGKVLMAGGYLVLDKPYAGLVLGLNaRFyaIVKPINEevgaWKWDVRVKSPQFSDrewlYKISLNhlTLQSVSASDSR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  72 D---NPF-QYIIAA---------------------IQVTEDYV-QALGKPTQKYHLSVN-SDLDSGTGKKYGLGSSAAVT 124
Cdd:TIGR01219  83 NpfvNPFiQYAIAAvhlyfdkeslhklllqglditILGDNAYYsQPESLGTLAPFASITfNAAEKPEVAKTGLGSSAAMT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 125 VATIKAL------------CQLYHLNVS-KVQLFKLAAIAHFSVQGN-GSLGDVASSVFGGLItYCSFDRQWLSEFLHKI 190
Cdd:TIGR01219 163 TALVAALlhylgvvdlsdpDKEGKFGCSdLDVIHNLAQTAHCLAQGKvGSGFDVSAAVYGSQR-YRRFSPELISFLQVAI 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 191 T-------LPELLKLEWPRlEITPLQIPPVLRFLVGWTGSPASTSQLIDKV-----------------------ELKKGK 240
Cdd:TIGR01219 242 TglplnevLGTIVKGKWDN-KRTEFSLPPLMNLFMGDPGGGSSTPSMVGKVkkwqmsdpeesrenwqnlsdanlELETKL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 241 HGIHYERFLHD-----------SNKCVREITNGFRQnnIRLIMQNIkknRELLQSLSQMAGVPIETPQLTRLIEIAEQFG 309
Cdd:TIGR01219 321 NDLSKLAKDHWdvylrvikvltSEKCVLHATEELLE--AREAMLRI---RRLMRQITEEASVDIEPESQTQLLDSTMSLE 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2260484600 310 GV--AKTSGAGGGDCGIVLIKSDCDI-AGLKAAWREADIEPLDLS 351
Cdd:TIGR01219 396 GVllAGVPGAGGFDAIFAITLGDVDSgTKLTQAWSSHNVLALDVR 440
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 100-171 5.34e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.25  E-value: 5.34e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2260484600 100 HLSVNSDLDSGTGkkygLGSSAAVTVATIKALCQLYHLNvskvqLFKLAAIAHFSVQ-GNGSLGDVASSVFGG 171
Cdd:pfam00288   1 DIEIESNIPLGAG----LGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGgGRGGGMDVAASLYGG 64
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 263-343 4.05e-11

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 58.64  E-value: 4.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 263 FRQNNIRLIMQNIKKNRELLQSLSQmagVPIETPQLTRLIEIAEQFGGVAKTSGAGGGDCGIVLIKSDCDIAGLKAAWRE 342
Cdd:pfam08544   5 LLRGDLEELGKLLTESAESLEPLLV---VGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVARALRE 81


                  .
gi 2260484600 343 A 343
Cdd:pfam08544  82 A 82
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 8-343 4.69e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 62.95  E-value: 4.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   8 GKLYLAGEYAVVeNGNPAIIAAVNRFVTVTIDENTDRCSItskqyenhlvhwerinsrMVVDDRDNPFQYIIaaiQVTED 87
Cdd:PTZ00298   17 GKVILFGEHFVV-YGAEAIVAGIDEYTECRLELTKGVPGL------------------QVVDQRPAVPGYIV---EKREE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  88 YVQALGKPTQkyHLSVNSDLDSGTGK-------KYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIAHFSVQGNGS 160
Cdd:PTZ00298   75 QRKAHQLVLR--HLNIDTSVDGLKMHlggplvpSSGIGASASDVVSLSRALSELYQLNLTEEEVNLSAFVGEGGYHGTPS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 161 LGDVASSVFGGLITYcsfdRQWLSEFLHKitlpellklewprleitPLQIPPVLRFLVGWTGSPASTSQLIDKVELKKGK 240
Cdd:PTZ00298  153 GADNTAATYGGLISY----RRVNGKSVFK-----------------RIAFQQPLYLVVCSTGITASTTKVVGDVRKLKEN 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 241 HGIHYERFLHDSNKCVREITNGFRQNNIRLIMQNIKKNRELLQSLSqmagvpIETPQLTRLIEIAEQFGGV-AKTSGAGG 319
Cdd:PTZ00298  212 QPTWFNRLLENYNACVSEAKEALQKGNLFRVGELMNANHDLCQKLT------VSCRELDSIVQTCRTYGALgAKMSGTGR 285

                         330       340
                  ....*....|....*....|....*...
gi 2260484600 320 GDCGIVLIKS----DCDIAGLKAAWREA 343
Cdd:PTZ00298  286 GGLVVALAASedqrDAIAKAVRARCPEA 313
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 81-194 4.67e-07

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 50.87  E-value: 4.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  81 AIQVTEDYVQALGKPTQKYHLSVNSDLDSGtgkkYGLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAI--AHfsvqgn 158
Cdd:COG0083    61 VYQAALALLEKLGKEPPGLRIEIEKGIPLG----RGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEgeGH------ 130

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2260484600 159 gslGD-VASSVFGGLITYCSFDRQWLSeflHKITLPE 194
Cdd:COG0083   131 ---PDnVAPALLGGLVLSRSDGEPVRV---VRLPVPP 161
PLN02677 PLN02677
mevalonate kinase
 2-327 4.69e-07

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 50.99  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   2 IKTSTPGKLYLAGEYAVVeNGNPAIIAAVNRFVTVTI-----DENTDRCSITSKQ-----------YENHLVHWERINSR 65
Cdd:PLN02677    3 VKARAPGKIILAGEHAVV-HGSTAVAAAIDLYTYVSLrfppsAENDDTLKLQLKDlglefswplarIKEALPDLGTPCPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  66 MV--------------VDDRDNPFQYIIAAIQVTED---YVQALG-KPTQkyhLSVNSDLDSGTgkkyGLGSSAAVTVAT 127
Cdd:PLN02677   82 TPtscseetlksiaalVEEQNIPEAKIWLSSGVSAFlwlYTSILGfNPAT---VVVTSELPLGS----GLGSSAAFCVAL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 128 IKALCQL-------------YHLNVSKVQL-----FKLAAIAHfsvqGNGSLGDVASSVFGGLITYCSFdrqwlseflhk 189
Cdd:PLN02677  155 SAALLAAsdsisvstggngwSSLDETDLELvnkwaFEGEKIIH----GKPSGIDNTVSTYGNMIKFKSG----------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600 190 itlpellklewprlEITPLQIPPVLRFLVGWTGSPASTSQLIDKVELKKGKHGIHYERFLHDSNKCVREITNGFR--QNN 267
Cdd:PLN02677  220 --------------ELTRLQSNMPLKMLITNTRVGRNTKALVAGVSERALRHPDAMKSVFNAVDSISEELATIIQspAED 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2260484600 268 IRLIMQNIKKNRELL---QSLSQMAGV---PIETpqltrLIEIAEQFGGVAKTSGAGGGDCGIVLI 327
Cdd:PLN02677  286 ELSITEKEEKLKELMemnQGLLQCMGVshsSIET-----VLRTTLKYKLVSKLTGAGGGGCVLTLL 346
PRK01212 PRK01212
homoserine kinase; Provisional
 116-173 5.06e-07

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 50.53  E-value: 5.06e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2260484600 116 GLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAI--AHfsvqgngslGD-VASSVFGGLI 173
Cdd:PRK01212   95 GLGSSAASIVAGLVAANELAGLPLSKEELLQLATEgeGH---------PDnVAPALLGGLV 146
PRK03817 PRK03817
galactokinase; Provisional
 2-148 7.96e-05

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 44.22  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600   2 IKTSTPGKLYLAGEYAVVENGNpAIIAAVNRFVTVTIdENTDRCSITSKQ----YENHLVHWERINSRmvVDdrdnpfqY 77
Cdd:PRK03817    1 MKVKSPGRVNLIGEHTDYNDGY-VLPFAINLYTFLEI-EKSEKFIFYSENfneeKTFELDKLEKLNSW--AD-------Y 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2260484600  78 IIAAIQVtedyVQALGKPTQKYHLSVNSDLDSGTGkkygLGSSAAVTVATIKALCQLYHLNVSKVQLFKLA 148
Cdd:PRK03817   70 IKGVIWV----LEKRGYEVGGVKGKVSSNLPIGAG----LSSSASLEVAVAYALNEAYNLNLSKLELALLA 132
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 28-172 2.71e-04

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 42.39  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260484600  28 AAVNRFVTVTIDENTDRcSITSKQYENHLVHWERINSRMvvddRDNPFQyiiaaiQVTEDYVQALGKPTQKYHLSVNSDL 107
Cdd:TIGR00191  21 AALSLYLGLTVTDVVAQ-ESDDTEIEAEGEGVEKIPTEP----TDNLIY------QVAKRFLDQLGIRMPPVKVTLEKNI 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2260484600 108 DSGTGkkygLGSSAAVTVATIKALCQLYHLNVSKVQLFKLAAIahfsvqGNGSLGDVASSVFGGL 172
Cdd:TIGR00191  90 PLGRG----LGSSAAAIVAALAAANELCGLPLSKERLLDYASE------LEGHPDNVAPALLGGF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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