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Conserved domains on  [gi|2231426418|gb|UPO24623|]
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tetracycline-inactivating monooxygenase Tet(X3) (plasmid) [Acinetobacter portensis]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 19-386 2.50e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 2.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDlhkGSGQEAMKKAGLLQTYYDLALPM-GVNIAD-EKG 96
Cdd:COG0654     6 VLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIALS---PRSLELLRRLGLWDRLLARGAPIrGIRVRDgSDG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  97 NILSTKNVKPENRFDNPEINRNDLRAILLNSLE--NDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKI 174
Cdd:COG0654    83 RVLARFDAAETGLPAGLVVPRADLERALLEAARalGVELRFGTEVTGLEQDADGVTVTLADGRTLRADLVVGADGARSAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 175 RSfvtdtqveetgtfniqadilqpeincpgffqlcngnrlmaghqgillfanpnnngalYLGISFKTpdewknkipLDFQ 254
Cdd:COG0654   163 RR---------------------------------------------------------LLGIGFTG---------RDYP 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 255 DRNSVADF---LLKRFSKWSEVYKQLI----RSVSTFQCLPTRKFPLNNdwksnrplpITMIGDAAHLMSPFAGQGVNTG 327
Cdd:COG0654   177 QRALWAGVrteLRARLAAAGPRLGELLelspRSAFPLRRRRAERWRRGR---------VVLLGDAAHTMHPLGGQGANLA 247

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 328 LLDALILSENLTNGEF-TSIENAIENYEQQMFVYAKDTQDESTENeTEMFSPNFSFQKLL 386
Cdd:COG0654   248 LRDAAALAWKLAAALRgRDDEAALARYERERRPRAARVQRAADAL-GRLFHPDSPPLRLL 306
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 19-386 2.50e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 2.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDlhkGSGQEAMKKAGLLQTYYDLALPM-GVNIAD-EKG 96
Cdd:COG0654     6 VLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIALS---PRSLELLRRLGLWDRLLARGAPIrGIRVRDgSDG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  97 NILSTKNVKPENRFDNPEINRNDLRAILLNSLE--NDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKI 174
Cdd:COG0654    83 RVLARFDAAETGLPAGLVVPRADLERALLEAARalGVELRFGTEVTGLEQDADGVTVTLADGRTLRADLVVGADGARSAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 175 RSfvtdtqveetgtfniqadilqpeincpgffqlcngnrlmaghqgillfanpnnngalYLGISFKTpdewknkipLDFQ 254
Cdd:COG0654   163 RR---------------------------------------------------------LLGIGFTG---------RDYP 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 255 DRNSVADF---LLKRFSKWSEVYKQLI----RSVSTFQCLPTRKFPLNNdwksnrplpITMIGDAAHLMSPFAGQGVNTG 327
Cdd:COG0654   177 QRALWAGVrteLRARLAAAGPRLGELLelspRSAFPLRRRRAERWRRGR---------VVLLGDAAHTMHPLGGQGANLA 247

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 328 LLDALILSENLTNGEF-TSIENAIENYEQQMFVYAKDTQDESTENeTEMFSPNFSFQKLL 386
Cdd:COG0654   248 LRDAAALAWKLAAALRgRDDEAALARYERERRPRAARVQRAADAL-GRLFHPDSPPLRLL 306
PRK06753 PRK06753
hypothetical protein; Provisional
 18-355 9.11e-27

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 109.78  E-value: 9.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNdrEARIFGGTLdlhkGSGQEAMKKAGLlqtyYDLA---------LPmG 88
Cdd:PRK06753    2 KIAIIGAGIGGLTAAALLQEQGHEVKVFEKNE--SVKEVGAGI----GIGDNVIKKLGN----HDLAkgiknagqiLS-T 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  89 VNIADEKGNILSTknVKPENRFDNPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILAN 168
Cdd:PRK06753   71 MNLLDDKGTLLNK--VKLKSNTLNVTLHRQTLIDIIKSYVKEDAIFTGKEVTKIENETDKVTIHFADGESEAFDLCIGAD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 169 GGMSKIRSFVT-DTQVEETGTFNIQADILQPEINCPGFFQLCNGNRlmaGHQGILLFanPNNNGALYLGISFKTPD-EWK 246
Cdd:PRK06753  149 GIHSKVRQSVNaDSKVRYQGYTCFRGLIDDIDLKLPDCAKEYWGTK---GRFGIVPL--LNNQAYWFITINAKERDpKYS 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 247 NKIPLDFQDR-NSVADFLLKRFSKWSEVyKQLIRSVSTFQclptrkfPLNNDWKSNrplpITMIGDAAHLMSPFAGQGVN 325
Cdd:PRK06753  224 SFGKPHLQAYfNHYPNEVREILDKQSET-GILHHDIYDLK-------PLKSFVYGR----IVLLGDAAHATTPNMGQGAG 291

                         330       340       350
                  ....*....|....*....|....*....|
gi 2231426418 326 TGLLDALILSENLTNgefTSIENAIENYEQ 355
Cdd:PRK06753  292 QAMEDAIVLANCLNA---YDFEKALQRYDK 318
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 19-331 9.01e-14

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 71.59  E-value: 9.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDrearifggTLDLHKGSGQ-----EAMKKAGLLQTYYDLALP---MGVN 90
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVERHAT--------TSVLPRAHGLnqrtmELLRQAGLEDRILAEGVPhegMGLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  91 IADEKGNILSTKNVKPENRFDNPEinrNDLRAILLNSLEND--TVIWDRKLVMLEPGKKKWTLTFENKPSET-----ADL 163
Cdd:pfam01494  76 FYNTRRRADLDFLTSPPRVTVYPQ---TELEPILVEHAEARgaQVRFGTEVLSLEQDGDGVTAVVRDRRDGEeytvrAKY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 164 VILANGGMSKIRSFVtDTQVEETGT-----FNIQADILQPEINCPGFFQLCngnrlmaghqgiLLFANPNNNGALyLGIS 238
Cdd:pfam01494 153 LVGCDGGRSPVRKTL-GIEFEGFEGvpfgsLDVLFDAPDLSDPVERAFVHY------------LIYAPHSRGFMV-GPWR 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 239 FKTPDEWKNKIPLDFQDRNSVADFLLkrfskwsEVYKQLIRSVS-----TFQCLPTRKFPLN----NDWKSNRplpITMI 309
Cdd:pfam01494 219 SAGRERYYVQVPWDEEVEERPEEFTD-------EELKQRLRSIVgidlaLVEILWKSIWGVAsrvaTRYRKGR---VFLA 288

                         330       340
                  ....*....|....*....|..
gi 2231426418 310 GDAAHLMSPFAGQGVNTGLLDA 331
Cdd:pfam01494 289 GDAAHIHPPTGGQGLNTAIQDA 310
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 18-342 1.48e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 59.14  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERdNDREAR---IFGG-TLDLHKGSgQEAMKKAGLLQTyydlalpmgvniad 93
Cdd:TIGR01988   1 DIVIVGGGMVGLALALALARSGLKVALIEA-TPLPAPadpGFDNrVSALSAAS-IRLLEKLGVWDK-------------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  94 ekgniLSTKNVKP-------------ENRFDNPEINRNDL---------RAILLNSLEND---TVIWDRKLVMLEPGKKK 148
Cdd:TIGR01988  65 -----IEPARAQPirdihvsdggsfgALRFDADEIGLEALgyvvenrvlQQALWERLQELpnvTLLCPARVVELPRHSDH 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 149 WTLTFENKPSETADLVILANGGMSKIRSFvtdtqveetgtFNIQADILQPEincpgffQLCngnrLMAghqgILLFANPN 228
Cdd:TIGR01988 140 VELTLDDGQQLRARLLVGADGANSKVRQL-----------AGIPTTGWDYG-------QSA----VVA----NVKHERPH 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 229 NNGA----LYLG-ISFktpdewknkIPLdFQDRNSV--------ADFLL----KRFSKwsEVYKQLIRSVSTFQCLPTRK 291
Cdd:TIGR01988 194 QGTAwerfTPTGpLAL---------LPL-PDNRSSLvwtlppeeAERLLalsdEEFLA--ELQRAFGSRLGAITLVGERH 261

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2231426418 292 -FPLN----NDWKSNRplpITMIGDAAHLMSPFAGQGVNTGLLDALILSENLTNGE 342
Cdd:TIGR01988 262 aFPLSlthaKRYVAPR---LALIGDAAHTIHPLAGQGLNLGLRDVAALAEVLEDAR 314
threonine_DH_like cd08234
L-threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent ...
 18-51 2.64e-03

L-threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine, via NAD(H)-dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.


Pssm-ID: 176196 [Multi-domain]  Cd Length: 334  Bit Score: 39.43  E-value: 2.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGID-VSVYERDNDR 51
Cdd:cd08234   162 SVLVFGAGPIGLLLAQLLKLNGASrVTVAEPNEEK 196
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 19-386 2.50e-43

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 153.56  E-value: 2.50e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDlhkGSGQEAMKKAGLLQTYYDLALPM-GVNIAD-EKG 96
Cdd:COG0654     6 VLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIALS---PRSLELLRRLGLWDRLLARGAPIrGIRVRDgSDG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  97 NILSTKNVKPENRFDNPEINRNDLRAILLNSLE--NDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKI 174
Cdd:COG0654    83 RVLARFDAAETGLPAGLVVPRADLERALLEAARalGVELRFGTEVTGLEQDADGVTVTLADGRTLRADLVVGADGARSAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 175 RSfvtdtqveetgtfniqadilqpeincpgffqlcngnrlmaghqgillfanpnnngalYLGISFKTpdewknkipLDFQ 254
Cdd:COG0654   163 RR---------------------------------------------------------LLGIGFTG---------RDYP 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 255 DRNSVADF---LLKRFSKWSEVYKQLI----RSVSTFQCLPTRKFPLNNdwksnrplpITMIGDAAHLMSPFAGQGVNTG 327
Cdd:COG0654   177 QRALWAGVrteLRARLAAAGPRLGELLelspRSAFPLRRRRAERWRRGR---------VVLLGDAAHTMHPLGGQGANLA 247

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 328 LLDALILSENLTNGEF-TSIENAIENYEQQMFVYAKDTQDESTENeTEMFSPNFSFQKLL 386
Cdd:COG0654   248 LRDAAALAWKLAAALRgRDDEAALARYERERRPRAARVQRAADAL-GRLFHPDSPPLRLL 306
PRK06753 PRK06753
hypothetical protein; Provisional
 18-355 9.11e-27

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 109.78  E-value: 9.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNdrEARIFGGTLdlhkGSGQEAMKKAGLlqtyYDLA---------LPmG 88
Cdd:PRK06753    2 KIAIIGAGIGGLTAAALLQEQGHEVKVFEKNE--SVKEVGAGI----GIGDNVIKKLGN----HDLAkgiknagqiLS-T 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  89 VNIADEKGNILSTknVKPENRFDNPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILAN 168
Cdd:PRK06753   71 MNLLDDKGTLLNK--VKLKSNTLNVTLHRQTLIDIIKSYVKEDAIFTGKEVTKIENETDKVTIHFADGESEAFDLCIGAD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 169 GGMSKIRSFVT-DTQVEETGTFNIQADILQPEINCPGFFQLCNGNRlmaGHQGILLFanPNNNGALYLGISFKTPD-EWK 246
Cdd:PRK06753  149 GIHSKVRQSVNaDSKVRYQGYTCFRGLIDDIDLKLPDCAKEYWGTK---GRFGIVPL--LNNQAYWFITINAKERDpKYS 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 247 NKIPLDFQDR-NSVADFLLKRFSKWSEVyKQLIRSVSTFQclptrkfPLNNDWKSNrplpITMIGDAAHLMSPFAGQGVN 325
Cdd:PRK06753  224 SFGKPHLQAYfNHYPNEVREILDKQSET-GILHHDIYDLK-------PLKSFVYGR----IVLLGDAAHATTPNMGQGAG 291

                         330       340       350
                  ....*....|....*....|....*....|
gi 2231426418 326 TGLLDALILSENLTNgefTSIENAIENYEQ 355
Cdd:PRK06753  292 QAMEDAIVLANCLNA---YDFEKALQRYDK 318
PRK06847 PRK06847
hypothetical protein; Provisional
 17-354 2.53e-16

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 79.53  E-value: 2.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLdlhKGSGQEAMKKAGLLQTYYDLALPM-GVNIADEK 95
Cdd:PRK06847    5 KKVLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRVYGAGITL---QGNALRALRELGVLDECLEAGFGFdGVDLFDPD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  96 GNILSTknvKPENRFDNPE------INRNDLRAILLNSLE--NDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILA 167
Cdd:PRK06847   82 GTLLAE---LPTPRLAGDDlpggggIMRPALARILADAARaaGADVRLGTTVTAIEQDDDGVTVTFSDGTTGRYDLVVGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 168 NGGMSKIRS--FVTDTQVEETGT----FNIQadiLQPEINCPGFFQlcnGNRLMAGhqgillfANPNNNGALYLGISFKT 241
Cdd:PRK06847  159 DGLYSKVRSlvFPDEPEPEYTGQgvwrAVLP---RPAEVDRSLMYL---GPTTKAG-------VVPLSEDLMYLFVTEPR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 242 PDewKNKIPLD-FQDRnsVADfLLKRFSkwSEVYKQLIRSVSTFQCLPTRKFP---LNNDWKSNRplpITMIGDAAHLMS 317
Cdd:PRK06847  226 PD--NPRIEPDtLAAL--LRE-LLAPFG--GPVLQELREQITDDAQVVYRPLEtllVPAPWHRGR---VVLIGDAAHATT 295

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2231426418 318 PFAGQGVNTGLLDALILSENLTNGEftSIENAIENYE 354
Cdd:PRK06847  296 PHLAQGAGMAIEDAIVLAEELARHD--SLEAALQAYY 330
PRK05868 PRK05868
FAD-binding protein;
17-371 1.78e-14

FAD-binding protein;


Pssm-ID: 180297 [Multi-domain]  Cd Length: 372  Bit Score: 74.25  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDndREARIFGGTLDLhKGSGQEAMKKAGLLQTYYDLALPM-GVNIADEK 95
Cdd:PRK05868    2 KTVVVSGASVAGTAAAYWLGRHGYSVTMVERH--PGLRPGGQAIDV-RGPALDVLERMGLLAAAQEHKTRIrGASFVDRD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  96 GNILS--TKNVKPENRFDNPEIN--RNDLRAILLNSLENDT-VIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGG 170
Cdd:PRK05868   79 GNELFrdTESTPTGGPVNSPDIEllRDDLVELLYGATQPSVeYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 171 MSKIRSFV---TDTQVEETGTFniqADILqpeiNCPGFFQL------CNGNRLMAGhqgiLLFANPNNNGALYLGIsfkt 241
Cdd:PRK05868  159 HSNVRRLVfgpEEQFVKRLGTH---AAIF----TVPNFLELdywqtwHYGDSTMAG----VYSARNNTEARAALAF---- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 242 pdeWKNKIPLDFQDRNSVADFLLKRFSKWSEVYKQLI---RSVSTFQCLPTRKFPLNNdWKSNRplpITMIGDAAHLMSP 318
Cdd:PRK05868  224 ---MDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLhymRSAPDFYFDEMSQILMDR-WSRGR---VALVGDAGYCCSP 296

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2231426418 319 FAGQGVNTGLLDALILSENL-TNGEftSIENAIENYEQQMFVYAKDTQDESTEN 371
Cdd:PRK05868  297 LSGQGTSVALLGAYILAGELkAAGD--DYQLGFANYHAEFHGFVERNQWLVSDN 348
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 19-331 9.01e-14

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 71.59  E-value: 9.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDrearifggTLDLHKGSGQ-----EAMKKAGLLQTYYDLALP---MGVN 90
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVERHAT--------TSVLPRAHGLnqrtmELLRQAGLEDRILAEGVPhegMGLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  91 IADEKGNILSTKNVKPENRFDNPEinrNDLRAILLNSLEND--TVIWDRKLVMLEPGKKKWTLTFENKPSET-----ADL 163
Cdd:pfam01494  76 FYNTRRRADLDFLTSPPRVTVYPQ---TELEPILVEHAEARgaQVRFGTEVLSLEQDGDGVTAVVRDRRDGEeytvrAKY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 164 VILANGGMSKIRSFVtDTQVEETGT-----FNIQADILQPEINCPGFFQLCngnrlmaghqgiLLFANPNNNGALyLGIS 238
Cdd:pfam01494 153 LVGCDGGRSPVRKTL-GIEFEGFEGvpfgsLDVLFDAPDLSDPVERAFVHY------------LIYAPHSRGFMV-GPWR 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 239 FKTPDEWKNKIPLDFQDRNSVADFLLkrfskwsEVYKQLIRSVS-----TFQCLPTRKFPLN----NDWKSNRplpITMI 309
Cdd:pfam01494 219 SAGRERYYVQVPWDEEVEERPEEFTD-------EELKQRLRSIVgidlaLVEILWKSIWGVAsrvaTRYRKGR---VFLA 288

                         330       340
                  ....*....|....*....|..
gi 2231426418 310 GDAAHLMSPFAGQGVNTGLLDA 331
Cdd:pfam01494 289 GDAAHIHPPTGGQGLNTAIQDA 310
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
19-335 2.56e-13

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 71.09  E-value: 2.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERdndrEARIFGG----TLDlhkgsgQEAMKkagLLQTyydlalpmgVNIADE 94
Cdd:PRK06183   13 VVIVGAGPVGLTLANLLGQYGVRVLVLER----WPTLYDLpravGID------DEALR---VLQA---------IGLADE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  95 ----------------KGNILSTKNVKPE--------NRFDNPEINRNdLRAiLLNSLENDTVIWDRKLVMLEPGKKKWT 150
Cdd:PRK06183   71 vlphttpnhgmrfldaKGRCLAEIARPSTgefgwprrNAFHQPLLEAV-LRA-GLARFPHVRVRFGHEVTALTQDDDGVT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 151 LTFEN---KPSE-TADLVILANGGMSKIRSFVtDTQVEETGTFN----IQADILQPEINCPGFFQLCNGNR---LMAGHQ 219
Cdd:PRK06183  149 VTLTDadgQRETvRARYVVGCDGANSFVRRTL-GVPFEDLTFPErwlvVDVLIANDPLGGPHTYQYCDPARpytSVRLPH 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 220 GILLFanpnnngalylgiSFKT-PDEwknkIPLDFQDRNSVADFLLKRFSKWSEVykQLIRS-VSTFQ-CLPTRkfplnn 296
Cdd:PRK06183  228 GRRRW-------------EFMLlPGE----TEEQLASPENVWRLLAPWGPTPDDA--ELIRHaVYTFHaRVADR------ 282

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2231426418 297 dWKSNRPLpitMIGDAAHLMSPFAGQGVNTGLLDALILS 335
Cdd:PRK06183  283 -WRSGRVL---LAGDAAHLMPPFAGQGMNSGIRDAANLA 317
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 18-342 1.48e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 59.14  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERdNDREAR---IFGG-TLDLHKGSgQEAMKKAGLLQTyydlalpmgvniad 93
Cdd:TIGR01988   1 DIVIVGGGMVGLALALALARSGLKVALIEA-TPLPAPadpGFDNrVSALSAAS-IRLLEKLGVWDK-------------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  94 ekgniLSTKNVKP-------------ENRFDNPEINRNDL---------RAILLNSLEND---TVIWDRKLVMLEPGKKK 148
Cdd:TIGR01988  65 -----IEPARAQPirdihvsdggsfgALRFDADEIGLEALgyvvenrvlQQALWERLQELpnvTLLCPARVVELPRHSDH 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 149 WTLTFENKPSETADLVILANGGMSKIRSFvtdtqveetgtFNIQADILQPEincpgffQLCngnrLMAghqgILLFANPN 228
Cdd:TIGR01988 140 VELTLDDGQQLRARLLVGADGANSKVRQL-----------AGIPTTGWDYG-------QSA----VVA----NVKHERPH 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 229 NNGA----LYLG-ISFktpdewknkIPLdFQDRNSV--------ADFLL----KRFSKwsEVYKQLIRSVSTFQCLPTRK 291
Cdd:TIGR01988 194 QGTAwerfTPTGpLAL---------LPL-PDNRSSLvwtlppeeAERLLalsdEEFLA--ELQRAFGSRLGAITLVGERH 261

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2231426418 292 -FPLN----NDWKSNRplpITMIGDAAHLMSPFAGQGVNTGLLDALILSENLTNGE 342
Cdd:TIGR01988 262 aFPLSlthaKRYVAPR---LALIGDAAHTIHPLAGQGLNLGLRDVAALAEVLEDAR 314
PRK07588 PRK07588
FAD-binding domain;
17-386 3.46e-08

FAD-binding domain;


Pssm-ID: 169028 [Multi-domain]  Cd Length: 391  Bit Score: 54.74  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNdrEARIFGGTLDLHkGSGQEAMKKAGLLQTYYDLALPM-GVNIADEK 95
Cdd:PRK07588    1 MKVAISGAGIAGPTLAYWLRRYGHEPTLIERAP--ELRTGGYMVDFW-GVGYEVAKRMGITDQLREAGYQIeHVRSVDPT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  96 GNI---LSTKNVKPENRFDNPEINRNDLRAILLNSLENDT-VIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGM 171
Cdd:PRK07588   78 GRRkadLNVDSFRRMVGDDFTSLPRGDLAAAIYTAIDGQVeTIFDDSIATIDEHRDGVRVTFERGTPRDFDLVIGADGLH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 172 SKIRS--FVTDTQVEE-----TGTFNIQADILQPEI-----NCPGF----FQLcNGNRLMAghqgILLFANPNNNGALyl 235
Cdd:PRK07588  158 SHVRRlvFGPERDFEHylgckVAACVVDGYRPRDERtyvlyNEVGRqvarVAL-RGDRTLF----LFIFRAEHDNPPL-- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 236 gisfkTPDEWKNKIpldfqdRNSVADF------LLKRFSKWSEVYkqlIRSVSTFQcLPTrkfplnndWKSNRplpITMI 309
Cdd:PRK07588  231 -----TPAEEKQLL------RDQFGDVgwetpdILAALDDVEDLY---FDVVSQIR-MDR--------WSRGR---VALV 284

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2231426418 310 GDAAHLMSPFAGQGVNTGLLDALILSENLTNGEFTSIEnAIENYEQQMFVYAKDTQDESTENeTEMFSPNFSFQKLL 386
Cdd:PRK07588  285 GDAAACPSLLGGEGSGLAITEAYVLAGELARAGGDHRR-AFDAYEKRLRPFIAGKQAAAAKF-LSVFAPKTRFGLYV 359
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 306-356 7.88e-08

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 53.68  E-value: 7.88e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2231426418 306 ITMIGDAAHLMSPFAGQGVNTGLLDALILSENLTN----GEFTSIENAIENYEQQ 356
Cdd:PRK05714  287 LALIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHaaerGERLADVRVLSRFERR 341
PRK06126 PRK06126
hypothetical protein; Provisional
 11-335 7.76e-07

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 51.15  E-value: 7.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  11 MNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERdndREARIFGGTLDLHKGSGQEAMKKAGLLQTYYDLALPmgVN 90
Cdd:PRK06126    2 MENTSETPVLIVGGGPVGLALALDLGRRGVDSILVER---KDGTAFNPKANTTSARSMEHFRRLGIADEVRSAGLP--VD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  91 IADEkgNILSTKNVKPE-NRFDNP-----------------------EINRNDLRAILLN---SLENDTVIWDRKLVMLE 143
Cdd:PRK06126   77 YPTD--IAYFTRLTGYElARFRLPsareaitpvggpdgswpspelphRIPQKYLEPILLEhaaAQPGVTLRYGHRLTDFE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 144 PGKKKWTLTFENKPSET-----ADLVILANGGMSKIRSFVTDTQVEETGtfniqadiLQPEIN----CPGFFQLCNGNRl 214
Cdd:PRK06126  155 QDADGVTATVEDLDGGEsltirADYLVGCDGARSAVRRSLGISYEGTSG--------LQRDLSiyirAPGLAALVGHDP- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 215 maghqgillfanpnnnGALYLGISfktPDEWKNKIPLDFQDRnsvadFLLK--RFSK----WSEVykqliRSVSTFQCLP 288
Cdd:PRK06126  226 ----------------AWMYWLFN---PDRRGVLVAIDGRDE-----WLFHqlRGGEdeftIDDV-----DARAFVRRGV 276

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2231426418 289 TRKFPL----NNDWKSNRPLPITM-------IGDAAHLMSPFAGQGVNTGLLDALILS 335
Cdd:PRK06126  277 GEDIDYevlsVVPWTGRRLVADSYrrgrvflAGDAAHLFTPTGGYGMNTGIGDAVNLA 334
PRK07045 PRK07045
putative monooxygenase; Reviewed
 18-358 8.05e-07

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 50.68  E-value: 8.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNdREARIFGGtlDLHKGSGQEAMKKAGLL--------------QTYYDL 83
Cdd:PRK07045    7 DVLINGSGIAGVALAHLLGARGHSVTVVERAA-RNRAQNGA--DLLKPSGIGVVRAMGLLddvfaagglrrdamRLYHDK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  84 ALPMGVNI--ADEKGNILStknvkpenrfdnpeINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKW-----TLTFENK 156
Cdd:PRK07045   84 ELIASLDYrsASALGYFIL--------------IPCEQLRRLLLAKLDGLPNVRLRFETSIERIERDAdgtvtSVTLSDG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 157 PSETADLVILANGGMSKIRSFVTDTQVEET--------GTFNIQADILQpeincpgffqlCNgnRLMAGHQGILLFANPN 228
Cdd:PRK07045  150 ERVAPTVLVGADGARSMIRDDVLRMPAERVpyatpmafGTIALTDSVRE-----------CN--RLYVDSNQGLAYFYPI 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 229 NNGALYLGISFktpdewknkiPLDfQDRNSVADF----LLKRFSKW----SEVYKQLIRSVSTFQCLPTRKFPLNNDWKS 300
Cdd:PRK07045  217 GDQATRLVVSF----------PAD-EMQGYLADTtrtkLLARLNEFvgdeSADAMAAIGAGTAFPLIPLGRMNLDRYHKR 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2231426418 301 NrplpITMIGDAAHLMSPFAGQGVNTGLLDALILSENLT---NGEFTsIENAIENYEQQMF 358
Cdd:PRK07045  286 N----VVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDlhlSGQIA-LADALERFERIRR 341
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 18-338 9.42e-07

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 50.54  E-value: 9.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREA-------RIFGGTLdlhkgSGQEAMKKAGL--------LQTYYD 82
Cdd:PRK08850    6 DVAIIGGGMVGLALAAALKESDLRIAVIEGQLPEEAlnelpdvRVSALSR-----SSEHILRNLGAwqgiearrAAPYIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  83 lalpMGVNIADEKGNIlstknvkpenRFDNPEINRNDL------RAILL------NSLENDTVIWDRKLVMLEPGKKKWT 150
Cdd:PRK08850   81 ----MEVWEQDSFARI----------EFDAESMAQPDLghivenRVIQLalleqvQKQDNVTLLMPARCQSIAVGESEAW 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 151 LTFENKPSETADLVILANGGMSKIRSfvtdtqveetgtfniQADI-----------LQPEINCPGffQLCNGNRLMAGHQ 219
Cdd:PRK08850  147 LTLDNGQALTAKLVVGADGANSWLRR---------------QMDIplthwdyghsaLVANVRTVD--PHNSVARQIFTPQ 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 220 GILLF---ANPNnngalYLGISFKT-PDEWKNKIPLDFQDRNsvadfllKRFSKWSEVYKQLIRSVSTFQCLPTrKFPLN 295
Cdd:PRK08850  210 GPLAFlpmSEPN-----MSSIVWSTePLRAEALLAMSDEQFN-------KALTAEFDNRLGLCEVVGERQAFPL-KMRYA 276

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2231426418 296 NDWKSNRplpITMIGDAAHLMSPFAGQGVNTGLLDALILSENL 338
Cdd:PRK08850  277 RDFVRER---VALVGDAAHTIHPLAGQGVNLGLLDAASLAQEI 316
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 15-60 1.32e-06

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 50.16  E-value: 1.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDnDReariFGGTL 60
Cdd:PRK12810  142 TGKKVAVVGSGPAGLAAADQLARAGHKVTVFERA-DR----IGGLL 182
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 16-59 1.52e-06

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 49.86  E-value: 1.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2231426418  16 DKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDreariFGGT 59
Cdd:COG2072     6 HVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADD-----VGGT 44
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 17-105 1.85e-06

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 48.91  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFG-GTLDLHkGSG--QEAMKKAGLLQTyyDLALpmgVNIAD 93
Cdd:COG0569    96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEeDVLVIV-GDAtdEEVLEEAGIEDA--DAVI---AATGD 169

                          90
                  ....*....|..
gi 2231426418  94 EKGNILSTKNVK 105
Cdd:COG0569   170 DEANILACLLAK 181
PRK07236 PRK07236
hypothetical protein; Provisional
 11-176 2.22e-06

hypothetical protein; Provisional


Pssm-ID: 235980 [Multi-domain]  Cd Length: 386  Bit Score: 49.15  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  11 MNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDndrearifGGTLDlHKGSG---QEAMKKAgLLQTYYDLALPM 87
Cdd:PRK07236    1 MTHMSGPRAVVIGGSLGGLFAALLLRRAGWDVDVFERS--------PTELD-GRGAGivlQPELLRA-LAEAGVALPADI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  88 GVNIA-----DEKGNILStknvkpenRFDNPEI--NRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSET 160
Cdd:PRK07236   71 GVPSReriylDRDGRVVQ--------RRPMPQTqtSWNVLYRALRAAFPAERYHLGETLVGFEQDGDRVTARFADGRRET 142

                         170
                  ....*....|....*.
gi 2231426418 161 ADLVILANGGMSKIRS 176
Cdd:PRK07236  143 ADLLVGADGGRSTVRA 158
PRK08243 PRK08243
4-hydroxybenzoate 3-monooxygenase; Validated
 19-61 2.83e-06

4-hydroxybenzoate 3-monooxygenase; Validated


Pssm-ID: 236198 [Multi-domain]  Cd Length: 392  Bit Score: 49.03  E-value: 2.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERdNDR---EARIFGGTLD 61
Cdd:PRK08243    5 VAIIGAGPAGLLLGQLLHLAGIDSVVLER-RSReyvEGRIRAGVLE 49
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 280-341 2.90e-06

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 48.98  E-value: 2.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2231426418 280 SVSTFQCLPTRKFPLN----NDWKSNRplpITMIGDAAHLMSPFAGQGVNTGLLDALILSENLTNG 341
Cdd:TIGR01989 308 RVIGVVDKSRAAFPLGlghaDEYVTKR---VALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEA 370
PRK08132 PRK08132
FAD-dependent oxidoreductase; Provisional
 19-338 4.83e-06

FAD-dependent oxidoreductase; Provisional


Pssm-ID: 236158 [Multi-domain]  Cd Length: 547  Bit Score: 48.33  E-value: 4.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDN-------------------DR---------------EARIFGG-----T 59
Cdd:PRK08132   26 VVVVGAGPVGLALAIDLAQQGVPVVLLDDDDtlstgsraicfakrsleifDRlgcgermvdkgvswnVGKVFLRdeevyR 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  60 LDLHKGSGQE--AMKKaglLQTYY------DLALpmgvniadekgnilstknvkpenrfDNPEInrnDLRaillnslend 131
Cdd:PRK08132  106 FDLLPEPGHRrpAFIN---LQQYYvegylvERAQ-------------------------ALPNI---DLR---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 132 tviWDRKLVMLEPGKKKWTLTFENkPSET----ADLVILANGGMSKIRSFVtdtQVEETGT-----FNIqADILQ----- 197
Cdd:PRK08132  145 ---WKNKVTGLEQHDDGVTLTVET-PDGPytleADWVIACDGARSPLREML---GLEFEGRtfedrFLI-ADVKMkadfp 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 198 --------PEINcPGffqlcngnrlmaghQGILLFANPNNngalylgisfktpdEWKnkipLDFQ---DRNSVA----DF 262
Cdd:PRK08132  217 terwfwfdPPFH-PG--------------QSVLLHRQPDN--------------VWR----IDFQlgwDADPEAekkpEN 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 263 LLKR----------FSK-WSEVYkqlirsvsTFQCLPTRKFPLNNdwksnrplpITMIGDAAHLMSPFAGQGVNTGLLDA 331
Cdd:PRK08132  264 VIPRvrallgedvpFELeWVSVY--------TFQCRRMDRFRHGR---------VLFAGDAAHQVSPFGARGANSGIQDA 326


                  ....*..
gi 2231426418 332 lilsENL 338
Cdd:PRK08132  327 ----DNL 329
PRK07208 PRK07208
hypothetical protein; Provisional
 17-58 6.10e-06

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 47.96  E-value: 6.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDreariFGG 58
Cdd:PRK07208    5 KSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPV-----VGG 41
PRK06185 PRK06185
FAD-dependent oxidoreductase;
309-342 6.24e-06

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 47.93  E-value: 6.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2231426418 309 IGDAAHLMSPFAGQGVNTGLLDAL----ILSENLTNGE 342
Cdd:PRK06185  289 IGDAAHAMSPVGGVGINLAIQDAVaaanILAEPLRRGR 326
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
306-342 6.79e-06

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 47.64  E-value: 6.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2231426418 306 ITMIGDAAHLMSPFAGQGVNTGLLDALILSENLTNGE 342
Cdd:PRK07608  282 VALVGDAAHLIHPLAGQGMNLGLRDVAALADVLAGRE 318
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 17-49 1.00e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 47.13  E-value: 1.00e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDN 49
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASD 34
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 15-60 1.65e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 46.67  E-value: 1.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDnDReariFGGTL 60
Cdd:COG0493   120 TGKKVAVVGSGPAGLAAAYQLARAGHEVTVFEAL-DK----PGGLL 160
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
21-50 1.99e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.13  E-value: 1.99e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 2231426418  21 IIGGGPVGLTMAKLLQQNGIDVSVYERDND 50
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDR 30
PRK07233 PRK07233
hypothetical protein; Provisional
 18-50 2.32e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 46.03  E-value: 2.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDND 50
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQ 33
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 15-47 2.37e-05

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 46.33  E-value: 2.37e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK11749  139 TGKKVAVIGAGPAGLTAAHRLARKGYDVTIFEA 171
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 15-47 2.61e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 46.28  E-value: 2.61e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK12769  326 SDKRVAIIGAGPAGLACADVLARNGVAVTVYDR 358
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 18-354 2.64e-05

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 45.92  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYErdnDREARIFGGTLDLHkgsgqeaMKKAGLLQTYYDLALPMGVNIADEKGN 97
Cdd:PRK08849    5 DIAVVGGGMVGAATALGFAKQGRSVAVIE---GGEPKAFEPSQPMD-------IRVSAISQTSVDLLESLGAWSSIVAMR 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  98 ILSTKNVK----PE--NRFDNPEINRNDLRAILLNSL------------ENDTVIWDRKLVMLEPGKKKWTLTFENKPSE 159
Cdd:PRK08849   75 VCPYKRLEtwehPEcrTRFHSDELNLDQLGYIVENRLiqlglwqqfaqyPNLTLMCPEKLADLEFSAEGNRVTLESGAEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 160 TADLVILANGGMSKIRsfvtdtQVEETGT-----------FNIQADILQPEINCPGFFQlcNGNRL---MAGHQGILLfa 225
Cdd:PRK08849  155 EAKWVIGADGANSQVR------QLAGIGItawdyrqhcmlINVETEQPQQDITWQQFTP--SGPRSflpLCGNQGSLV-- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 226 npnnngalylgisfktpdeWKNKiPLDFQDRNSVADFLLKrfskwSEVYKQLIRSVSTFQCLPTRKFPLN----NDWKSN 301
Cdd:PRK08849  225 -------------------WYDS-PKRIKQLSAMNPEQLR-----SEILRHFPAELGEIKVLQHGSFPLTrrhaQQYVKN 279

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2231426418 302 RplpITMIGDAAHLMSPFAGQGVNTGLLD-ALILSENLTNGEFTsiENAIENYE 354
Cdd:PRK08849  280 N---CVLLGDAAHTINPLAGQGVNLGFKDvDVLLAETEKQGVLN--DASFARYE 328
trkA PRK09496
Trk system potassium transporter TrkA;
17-51 3.01e-05

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 45.88  E-value: 3.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDR 51
Cdd:PRK09496  232 KRVMIVGGGNIGYYLAKLLEKEGYSVKLIERDPER 266
PRK06185 PRK06185
FAD-dependent oxidoreductase;
1-86 7.66e-05

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 44.46  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418   1 MTMRIDTDkqmnllsdknVAIIGGGPVGLTMAKLLQQNGIDVSVYER--DNDREARifGGTldLHKGSgQEAMKKAGLLQ 78
Cdd:PRK06185    1 MAEVETTD----------CCIVGGGPAGMMLGLLLARAGVDVTVLEKhaDFLRDFR--GDT--VHPST-LELMDELGLLE 65


                  ....*...
gi 2231426418  79 TYydLALP 86
Cdd:PRK06185   66 RF--LELP 71
PRK08013 PRK08013
oxidoreductase; Provisional
 308-331 1.59e-04

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 43.50  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|....
gi 2231426418 308 MIGDAAHLMSPFAGQGVNTGLLDA 331
Cdd:PRK08013  286 LVGDAAHTIHPLAGQGVNLGFMDA 309
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
308-336 1.93e-04

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 43.04  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*....
gi 2231426418 308 MIGDAAHLMSPFAGQGVNTGLLDALILSE 336
Cdd:PRK07333  284 LVGDAAHGIHPIAGQGLNLGLKDVAALAE 312
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
278-334 2.38e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 42.93  E-value: 2.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2231426418 278 IRSVSTFQCLPTRKfPLNNDWKSNRPLpitMIGDAAHLMSPFAGQGVNTGLLDALIL 334
Cdd:PRK08773  260 VRVASPRTAFPLRR-QLVQQYVSGRVL---TLGDAAHVVHPLAGQGVNLGLRDVAAL 312
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 18-340 2.40e-04

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 42.99  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGG--TLDLHKGSgQEAMKKAGLLQTYYDLALPM-GVNIADE 94
Cdd:PRK06617    3 NTVILGCGLSGMLTALSFAQKGIKTTIFESKSVKSPEFFKDirTTALTPHS-KNFLFSIDIWEELEKFVAEMqDIYVVDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  95 KGN-ILSTKNvkPENRFDNPEINRNDLRAILLNSLEND---TVIWDRKLVMLEPGKKKWTLTFENKPSEtADLVILANGG 170
Cdd:PRK06617   82 KASeILDLRN--DADAVLGYVVKNSDFKKILLSKITNNpliTLIDNNQYQEVISHNDYSIIKFDDKQIK-CNLLIICDGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 171 MSKIRSFVTDTQVEETG----TFNIQADilQPEINCP-------GFFQLCNgnrLMAGHQGILLFANPNNNGALYLGISF 239
Cdd:PRK06617  159 NSKVRSHYFANEIEKPYqtalTFNIKHE--KPHENCAmehflplGPFALLP---LKDQYASSVIWSTSSDQAALIVNLPV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 240 KTpdewknkipldfqdrnsvADFLLKRFSKWSEVYKQLIRSVSTFqclPTRKFpLNNDWKSNRplpITMIGDAAHLMSPF 319
Cdd:PRK06617  234 EE------------------VRFLTQRNAGNSLGKITIDSEISSF---PLKAR-IANRYFHNR---IVLIADTAHTVHPL 288

                         330       340
                  ....*....|....*....|.
gi 2231426418 320 AGQGVNTGLLDALILSENLTN 340
Cdd:PRK06617  289 AGQGLNQGIKDIEILSMIVSN 309
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
19-48 3.44e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 42.20  E-value: 3.44e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERD 48
Cdd:COG0665     5 VVVIGGGIAGLSTAYHLARRGLDVTVLERG 34
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 17-57 3.52e-04

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 42.11  E-value: 3.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYErdndREARIFG 57
Cdd:COG0446   125 KRAVVIGGGPIGLELAEALRKRGLKVTLVE----RAPRLLG 161
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 19-50 3.55e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 42.38  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDND 50
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLSVTLLERGDD 33
PRK06834 PRK06834
hypothetical protein; Provisional
 310-334 3.57e-04

hypothetical protein; Provisional


Pssm-ID: 235870 [Multi-domain]  Cd Length: 488  Bit Score: 42.31  E-value: 3.57e-04
                          10        20
                  ....*....|....*....|....*
gi 2231426418 310 GDAAHLMSPFAGQGVNTGLLDALIL 334
Cdd:PRK06834  271 GDAAHVHSPVGGQGLNTGVQDAVNL 295
PRK07538 PRK07538
hypothetical protein; Provisional
 19-46 3.77e-04

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 42.19  E-value: 3.77e-04
                          10        20
                  ....*....|....*....|....*...
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYE 46
Cdd:PRK07538    3 VLIAGGGIGGLTLALTLHQRGIEVVVFE 30
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 308-333 4.25e-04

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 42.28  E-value: 4.25e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2231426418 308 MIGDAAHLMSPFAGQGVNTG------LLDALI 333
Cdd:PRK08020  285 LVGDAAHTINPLAGQGVNLGyrdvdaLLDVLV 316
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
24-357 5.28e-04

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 41.49  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  24 GGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGtldlhkGSGQEAMKKAGLLQTYYDLALP---MGVNIADEKGNILs 100
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKICGG------GLLPRALEELEPLGLDEPLERPvrgARFYSPGGKSVEL- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 101 tknvkPENRFDNPEINRNDLRAILLNSLEND--TVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKI-RSF 177
Cdd:COG0644    74 -----PPGRGGGYVVDRARFDRWLAEQAEEAgaEVRTGTRVTDVLRDDGRVVVRTGDGEEIRADYVVDADGARSLLaRKL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 178 VTDTQVEETGTFN--IQADILQPEINC--PGFFQLCNGNRLMAGHqgilLFANPNNNGALYLGisfktpdewknkIPLDF 253
Cdd:COG0644   149 GLKRRSDEPQDYAlaIKEHWELPPLEGvdPGAVEFFFGEGAPGGY----GWVFPLGDGRVSVG------------IPLGG 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418 254 QDRNSVAD-FLLkrfskwsevykqlirsvstfqclptrkfplnndwksnrplpitmIGDAAHLMSPFAGQGVNTGLLDAL 332
Cdd:COG0644   213 PRPRLVGDgVLL--------------------------------------------VGDAAGFVDPLTGEGIHLAMKSGR 248

                         330       340
                  ....*....|....*....|....*....
gi 2231426418 333 ILSEN----LTNGEFTsiENAIENYEQQM 357
Cdd:COG0644   249 LAAEAiaeaLEGGDFS--AEALAEYERRL 275
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 15-58 7.30e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 41.37  E-value: 7.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERdndreARIFGG 58
Cdd:COG1233     2 MMYDVVVIGAGIGGLAAAALLARAGYRVTVLEK-----NDTPGG 40
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 17-47 8.88e-04

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 40.74  E-value: 8.88e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK14619    5 KTIAILGAGAWGSTLAGLASANGHRVRVWSR 35
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 15-46 1.01e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 41.25  E-value: 1.01e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2231426418  15 SDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYE 46
Cdd:PRK12814  192 SGKKVAIIGAGPAGLTAAYYLLRKGHDVTIFD 223
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
16-58 1.32e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 40.67  E-value: 1.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2231426418  16 DKNVAIIGGGPVGLTMAKLLQQNGIDVSVYE-RDndreaRIfGG 58
Cdd:COG1231     7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEaRD-----RV-GG 44
PRK07364 PRK07364
FAD-dependent hydroxylase;
308-339 1.47e-03

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 40.39  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2231426418 308 MIGDAAHLMSPFAGQGVNTGLLDALILSENLT 339
Cdd:PRK07364  298 LVGDAAHCCHPVGGQGLNLGIRDAAALAQVLQ 329
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 17-50 1.83e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.99  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDND 50
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGT 34
PRK09126 PRK09126
FAD-dependent hydroxylase;
19-47 2.01e-03

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 39.92  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|....*....
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK09126    6 IVVVGAGPAGLSFARSLAGSGLKVTLIER 34
PRK13984 PRK13984
putative oxidoreductase; Provisional
 16-49 2.14e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.14  E-value: 2.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2231426418  16 DKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDN 49
Cdd:PRK13984  283 NKKVAIVGSGPAGLSAAYFLATMGYEVTVYESLS 316
PRK08244 PRK08244
monooxygenase;
306-334 2.46e-03

monooxygenase;


Pssm-ID: 236199 [Multi-domain]  Cd Length: 493  Bit Score: 39.73  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*....
gi 2231426418 306 ITMIGDAAHLMSPFAGQGVNTGLLDALIL 334
Cdd:PRK08244  274 IFLAGDAAHIHFPAGGQGLNVGLQDAMNL 302
threonine_DH_like cd08234
L-threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent ...
 18-51 2.64e-03

L-threonine dehydrogenase; L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine, via NAD(H)-dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.


Pssm-ID: 176196 [Multi-domain]  Cd Length: 334  Bit Score: 39.43  E-value: 2.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGID-VSVYERDNDR 51
Cdd:cd08234   162 SVLVFGAGPIGLLLAQLLKLNGASrVTVAEPNEEK 196
PRK12831 PRK12831
putative oxidoreductase; Provisional
 16-46 2.73e-03

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 39.62  E-value: 2.73e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2231426418  16 DKNVAIIGGGPVGLTMAKLLQQNGIDVSVYE 46
Cdd:PRK12831  140 GKKVAVIGSGPAGLTCAGDLAKMGYDVTIFE 170
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
19-50 2.88e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 39.36  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQ-NGIDVSVYERDND 50
Cdd:COG0579     7 VVIIGAGIVGLALARELSRyEDLKVLVLEKEDD 39
Ala_dh_like cd01620
Alanine dehydrogenase and related dehydrogenases; Alanine dehydrogenase/Transhydrogenase, such ...
 18-77 2.94e-03

Alanine dehydrogenase and related dehydrogenases; Alanine dehydrogenase/Transhydrogenase, such as the hexameric L-alanine dehydrogenase of Phormidium lapideum, contain 2 Rossmann fold-like domains linked by an alpha helical region. Related proteins include Saccharopine Dehydrogenase (SDH), bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme, N(5)-(carboxyethyl)ornithine synthase, and Rubrum transdehydrogenase. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyrucate to L-alanine via reductive amination. Transhydrogenases found in bacterial and inner mitochondrial membranes link NAD(P)(H)-dependent redox reactions to proton translocation. The energy of the proton electrochemical gradient (delta-p), generated by the respiratory electron transport chain, is consumed by transhydrogenase in NAD(P)+ reduction. Transhydrogenase is likely involved in the regulation of the citric acid cycle. Rubrum transhydrogenase has 3 components, dI, dII, and dIII. dII spans the membrane while dI and dIII protrude on the cytoplasmic/matirx side. DI contains 2 domains with Rossmann folds, linked by a long alpha helix, and contains a NAD binding site. Two dI polypeptides (represented in this sub-family) spontaneously form a heterotrimer with one dIII in the absence of dII. In the heterotrimer, both dI chains may bind NAD, but only one is well-ordered. dIII also binds a well-ordered NADP, but in a different orientation than classical Rossmann domains.


Pssm-ID: 240621 [Multi-domain]  Cd Length: 317  Bit Score: 39.31  E-value: 2.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2231426418  18 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDR----EARIFGGTLDLHKGSGQEAMKKAGLL 77
Cdd:cd01620   164 KVLIIGAGVVGLGAAKIAKKLGANVLVYDIKEEKlkgvETLGGSRLRYSQKEELEKELKQTDIL 227
PRK05732 PRK05732
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 308-342 2.97e-03

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 235584 [Multi-domain]  Cd Length: 395  Bit Score: 39.45  E-value: 2.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2231426418 308 MIGDAAHLMSPFAGQGVNTGLLDALILSENLTNGE 342
Cdd:PRK05732  286 LVGNAAQTLHPIAGQGFNLGLRDVMSLAETLTQAL 320
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 19-134 3.15e-03

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 37.12  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGiDVSVYERDNDREARIFGGTLDLHKGSG--QEAMKKAGLLQtyYDLALpmgVNIADEKG 96
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGG-DVVVIDKDEERVEELREEGVPVVVGDAtdEEVLEEAGIEE--ADAVI---AATGDDEA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2231426418  97 NILSTKNVKpeNRFDNPEI---NRNDLRAILLNSLENDTVI 134
Cdd:pfam02254  75 NILIVLLAR--ELNPDKKIiarANDPEHAELLRRLGADHVI 113
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 17-47 3.83e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 39.47  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK12771  138 KRVAVIGGGPAGLSAAYHLRRMGHAVTIFEA 168
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
19-57 4.36e-03

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 38.56  E-value: 4.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2231426418  19 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDR--EARIFG 57
Cdd:COG1226   127 VIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERveELRRFG 167
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 17-47 4.52e-03

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 38.82  E-value: 4.52e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYER 47
Cdd:PRK12770   19 KKVAIIGAGPAGLAAAGYLACLGYEVHVYDK 49
PLN02976 PLN02976
amine oxidase
 12-56 4.63e-03

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 39.47  E-value: 4.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2231426418   12 NLLSD----KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIF 56
Cdd:PLN02976   685 CVLCDsvdrKKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVY 733
PRK06184 PRK06184
hypothetical protein; Provisional
 310-331 5.09e-03

hypothetical protein; Provisional


Pssm-ID: 235728 [Multi-domain]  Cd Length: 502  Bit Score: 38.81  E-value: 5.09e-03
                          10        20
                  ....*....|....*....|..
gi 2231426418 310 GDAAHLMSPFAGQGVNTGLLDA 331
Cdd:PRK06184  287 GDAAHVHPPAGGQGLNTSVQDA 308
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 17-75 5.53e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 38.62  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDN------DRE-----ARIFGGTLDLHKGSGQEAMKKAG 75
Cdd:PRK06292  170 KSLAVIGGGVIGLELGQALSRLGVKVTVFERGDrilpleDPEvskqaQKILSKEFKIKLGAKVTSVEKSG 239
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 17-58 6.06e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 38.68  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2231426418  17 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERdndreARIFGG 58
Cdd:COG3349     4 PRVVVVGGGLAGLAAAVELAEAGFRVTLLEA-----RPRLGG 40
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 14-64 7.43e-03

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 35.91  E-value: 7.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2231426418  14 LSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARifgGTLDLHK 64
Cdd:pfam13241   5 LRGKRVLVVGGGEVAARKARKLLEAGAKVTVVSPEITPFLE---GLLDLIR 52
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 12-48 7.84e-03

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 38.30  E-value: 7.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2231426418  12 NLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERD 48
Cdd:PLN02172    6 NPINSQHVAVIGAGAAGLVAARELRREGHTVVVFERE 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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