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Conserved domains on  [gi|2216376453|gb|UOE32117|]
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galactokinase [Hymenobacter monticola]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
5-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 556.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   5 LAQALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELaNPAE 83
Cdd:COG0153     1 RLERLIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEF-DLDD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAP-SDTHWANYLLGVAAQLQLRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEH 162
Cdd:COG0153    80 LEPgEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 163 TYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILqqhye 242
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL----- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 243 GISSLRDATMEQLEALKGELGG-TVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLV 321
Cdd:COG0153   235 GVKSLRDVTLEDLEAARARLGDeVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216376453 322 EAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:COG0153   315 ELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
5-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 556.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   5 LAQALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELaNPAE 83
Cdd:COG0153     1 RLERLIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEF-DLDD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAP-SDTHWANYLLGVAAQLQLRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEH 162
Cdd:COG0153    80 LEPgEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 163 TYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILqqhye 242
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL----- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 243 GISSLRDATMEQLEALKGELGG-TVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLV 321
Cdd:COG0153   235 GVKSLRDVTLEDLEAARARLGDeVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216376453 322 EAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:COG0153   315 ELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378
PRK05322 PRK05322
galactokinase; Provisional
 6-385 2.70e-130

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 379.20  E-value: 2.70e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   6 AQALKADFQQRFGYAPLLVR-APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELA-NPAE 83
Cdd:PRK05322    3 KEELKKKFAEVFGEEAEDVFfSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEfDLDD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAPSDTH-WANYLLGVAAQLQLRGVAVP-GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAE 161
Cdd:PRK05322   83 LSFDKEDdWANYPKGVLKFLQEAGYKIDhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 162 HTYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILQQHY 241
Cdd:PRK05322  163 NEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 242 EgISSLRDATMEQLEALKGELG-GTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVL 320
Cdd:PRK05322  243 D-IKSLGELTEEEFDEYSYLIKdETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2216376453 321 VEAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:PRK05322  322 VEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGARE 386
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 7-385 1.52e-114

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 339.11  E-value: 1.52e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   7 QALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDL-NETLELANPAEI 84
Cdd:TIGR00131   2 ESIQKIFASAFGAKPdFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANAdNKFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  85 APSDTH-WANYLLGVAAQLQLRGVAVP-GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEH 162
Cdd:TIGR00131  82 DGSEVSdWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 163 TYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILQQhyE 242
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA--T 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 243 GISSLRDATMEQL---EALKGELGGTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDV 319
Cdd:TIGR00131 240 DKGALRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDE 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2216376453 320 LVEAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:TIGR00131 320 LVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 11-58 3.49e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 82.89  E-value: 3.49e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2216376453  11 ADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVG 58
Cdd:pfam10509   1 EAFEELFGKEPvGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVS 49
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
5-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 556.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   5 LAQALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELaNPAE 83
Cdd:COG0153     1 RLERLIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEF-DLDD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAP-SDTHWANYLLGVAAQLQLRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEH 162
Cdd:COG0153    80 LEPgEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 163 TYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILqqhye 242
Cdd:COG0153   160 EFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL----- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 243 GISSLRDATMEQLEALKGELGG-TVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLV 321
Cdd:COG0153   235 GVKSLRDVTLEDLEAARARLGDeVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216376453 322 EAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:COG0153   315 ELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378
PRK05322 PRK05322
galactokinase; Provisional
 6-385 2.70e-130

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 379.20  E-value: 2.70e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   6 AQALKADFQQRFGYAPLLVR-APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELA-NPAE 83
Cdd:PRK05322    3 KEELKKKFAEVFGEEAEDVFfSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEfDLDD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAPSDTH-WANYLLGVAAQLQLRGVAVP-GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAE 161
Cdd:PRK05322   83 LSFDKEDdWANYPKGVLKFLQEAGYKIDhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 162 HTYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILQQHY 241
Cdd:PRK05322  163 NEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 242 EgISSLRDATMEQLEALKGELG-GTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVL 320
Cdd:PRK05322  243 D-IKSLGELTEEEFDEYSYLIKdETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2216376453 321 VEAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:PRK05322  322 VEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGARE 386
PRK05101 PRK05101
galactokinase; Provisional
 4-385 1.06e-127

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 372.33  E-value: 1.06e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   4 TLAQALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDL-NETLELANP 81
Cdd:PRK05101    2 SLKQKTQSLFAQQFGYPPtHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYdNQQDEFSLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  82 AEIAPSDTH-WANYLLGVAAQLQLRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFA 160
Cdd:PRK05101   82 APIVPHPEQqWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 161 EHTYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAArIVLCNSGVKHSLASSEYNTRRQECERGVSILqqh 240
Cdd:PRK05101  162 ENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVA-VVIINSNVKRGLVDSEYNTRRQQCETAARFF--- 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 241 yeGISSLRDATMEQLEALKGELGGTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVL 320
Cdd:PRK05101  238 --GVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTL 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2216376453 321 VEAAQKAPGVF-GARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:PRK05101  316 VEIVKAVIGDQgGVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQ 381
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 7-385 1.52e-114

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 339.11  E-value: 1.52e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   7 QALKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDL-NETLELANPAEI 84
Cdd:TIGR00131   2 ESIQKIFASAFGAKPdFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANAdNKFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  85 APSDTH-WANYLLGVAAQLQLRGVAVP-GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEH 162
Cdd:TIGR00131  82 DGSEVSdWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 163 TYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILQQhyE 242
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA--T 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 243 GISSLRDATMEQL---EALKGELGGTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDV 319
Cdd:TIGR00131 240 DKGALRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDE 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2216376453 320 LVEAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:TIGR00131 320 LVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
PRK03817 PRK03817
galactokinase; Provisional
 24-385 2.95e-112

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 331.96  E-value: 2.95e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  24 VRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVglNKGDQIRLVAHDLNETLELaNPAEIAPSDThWANYLLGVAAQLQ 103
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEI--EKSEKFIFYSENFNEEKTF-ELDKLEKLNS-WADYIKGVIWVLE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 104 LRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGIMDQFASLFGRQG 183
Cdd:PRK03817   79 KRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 184 QVVRLDCRSLEYEYFPFDtQAARIVLCNSGVKHSLASSEYNTRRQECERGVSILqqhyeGISSLRDATMEQLEALKGelg 263
Cdd:PRK03817  159 HAIFLDTMTLEYEYVPFP-EDYEILVFDTGVKRELASSEYNERRQECEEALKIL-----GKKSSKEVTEEDLSKLPP--- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 264 gtVYRRCA-YVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLVEAAQKApGVFGARMMGGGFGG 342
Cdd:PRK03817  230 --LLRKRAgYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGFGG 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2216376453 343 CTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQTTIVAGVGV 385
Cdd:PRK03817  307 SAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRK 349
PRK00555 PRK00555
galactokinase; Provisional
 26-363 3.82e-79

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 247.85  E-value: 3.82e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  26 APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDlnETLELANPAEIAPSD-THWANYLLGVAAQLQL 104
Cdd:PRK00555    7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDR--ADGSARIPLDTTPGQvTGWAAYAAGVIWALRG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 105 RGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGIMDQFASLFGRQGQ 184
Cdd:PRK00555   85 AGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGAPKT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 185 VVRLDCRSLEYEYFPFDTQAARIVLC--NSGVKHSLASSEYNTRRQECERGVSILqqhyeGISSLRDATMEQLEALKGEL 262
Cdd:PRK00555  165 ALLIDFRDLTVRPVAFDPDAAGVVLLlmDSRARHRHAGGEYAARRASCERAAADL-----GVSSLRAVQDRGLAALGAIA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 263 GGTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLVEAAQKApGVFGARMMGGGFGG 342
Cdd:PRK00555  240 DPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARMTGGGFGG 318

                         330       340
                  ....*....|....*....|.
gi 2216376453 343 CTINLVAPDKVDAFIESVSKA 363
Cdd:PRK00555  319 CVIALVPADRAEDVADTVRRA 339
PLN02521 PLN02521
galactokinase
 9-383 1.69e-56

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 192.62  E-value: 1.69e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   9 LKADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELANPA----E 83
Cdd:PLN02521   35 LKAAFVEVYGAKPdLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVNDKYTTCTFPAdpdqE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  84 IAPSDTHWANYLL----GVAAQLQLRGVAVP---GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARV 156
Cdd:PLN02521  115 VDLANHKWGNYFIcgykGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQF 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 157 AQFAEHtYAGVQCGIMDQFASLFGRQGqVVRLdcrsleYEYFPfdTQAARIVLCNSG---VKHSLASSE--------YNT 225
Cdd:PLN02521  195 TCKCER-HIGTQSGGMDQAISIMAQQG-VAKL------IDFNP--VRATDVQLPAGGtfvIANSLAESNkavtaatnYNN 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 226 RRQECeRGVSIL---------QQHYEGISSLRDA-----------------------------TMEQLEALKGELGGTV- 266
Cdd:PLN02521  265 RVVEC-RLAAIVlavklgmsaEEAISKVKTLSDVeglcvsfagshgssdpavavkellhegpyTAEEIEEILGESLTSIf 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 267 ------------------YRRCAYVVQENARVVRACDCLNAGD-----LEGFGKEMYGSHAGLRDDYEVSCAELDVLVEA 323
Cdd:PLN02521  344 knsptslavlkaakhfklHQRAVHVYSEAKRVHAFRDTVSSSLseeekLKKLGDLMNESHYSCSVLYECSCPELEELVKV 423

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 324 AQKApGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYeeklglkletYQTTIVAGV 383
Cdd:PLN02521  424 CRDN-GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF----------YKSRIEKGV 472
PLN02865 PLN02865
galactokinase
 23-366 1.49e-51

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 177.69  E-value: 1.49e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  23 LVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLN-----ETLELANPAEIAPSD----THWAN 93
Cdd:PLN02865   32 VVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEgevrfRVDEIQHPIANVSSDskeeSNWGD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  94 YLLGVAAQLQLRGVAV-PGFDCVFAGTVPL-GAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGI 171
Cdd:PLN02865  112 YARGAVYALQSRGHALsQGITGYISGSEGLdSSGLSSSAAVGVAYLLALENANNLTVSPEDNIELDRLIENEYLGLRNGI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 172 MDQFASLFGRQGQVVRLDCRSLEYEYFPFDTQAA------RIVLCNSGVKHSLASSE-YNTRRQECERGVSILQQ---HY 241
Cdd:PLN02865  192 LDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfKILLAFSGLRHALTNKPgYNLRVSECQEAARFLLEasgND 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 242 EGISSLRDATMEQLEALKGELGGTVYRRCAYVVQENARVVRACDCLNAGDLEGFGKEMYGSHAGLRDDYEVSCAELDVLV 321
Cdd:PLN02865  272 ELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLY 351

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2216376453 322 EAAQKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEE 366
Cdd:PLN02865  352 EILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396
PTZ00290 PTZ00290
galactokinase; Provisional
 1-384 8.46e-51

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 176.94  E-value: 8.46e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453   1 MSATLAQaLKADFQQRFGYAP-------LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNK---GDQIRLVAH 70
Cdd:PTZ00290   11 LDSTLST-LKPIFLETFKVENdadvewlLFTFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKhfcDHKLRFATE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  71 DlNETLELANPAEiAPSDTHWANYLLGvAAQLQLRGVAVP-------GFDCVFAGTVPLGAGMSSSAAIECGLAFALNQL 143
Cdd:PTZ00290   90 T-DEHFVLDHLGG-AKHNKAWTTFVRG-AATLRLNRLGVAidapslqGVCMVVHGTLPMGAGMSASASFGVALLNAINTV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 144 LDAGF--------------------EKMELARVAQFAEHTYAGVQCGIMDQFASLFGRQGQVVRLDCRSLEYEYF---PF 200
Cdd:PTZ00290  167 VTRRYkgcptspgrrysilppmskeELIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHdmtPL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 201 DTQAARIVLCNSGVKHSL---ASSEYNTRRQECERGVSILQQH-YEGIS-SLRDATMEQ------------LEALKGELG 263
Cdd:PTZ00290  247 LGDGACFLLIDSMIKHDLlggTAGMYNTVRSDQEGAQKKIGKHrYRGKPfTFSDLVRNPkkytfdgdvvafMESCKPLMT 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 264 GTVYRRCAYVVQEN-------------------ARVVRACDCLNAGdlegfgkemygsHAGLRDDYEVSCAELDVLVEAA 324
Cdd:PTZ00290  327 PGEFERGTYNIMEQirtlefiklndpelplsreERFRKAGEILNAG------------HQGMRDLMKITTPELDFIHELI 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 325 QKAPGVFGARMMGGGFGGCTINLVAPDKVDAFIESVSKAYEEKLGLKLETYQttIVAGVG 384
Cdd:PTZ00290  395 NEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKARFGVENDVYP--VVAGDG 452
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 26-348 1.38e-26

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 107.24  E-value: 1.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  26 APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKGDQIRLVAHDLNETLELANPAeiapsDTHWANYLLGVAAQLQLR 105
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLA-----DAALRYIKAAIEAALEYL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 106 GVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGvQCGIMDQFASLFGrqgQV 185
Cdd:COG1577    76 GLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHG-NPSGLDTAASTYG---GP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 186 VRLDcRSLEYEYFPFDTQAaRIVLCNSGVKHSlasseynTRRQecergVSILQQHYEGISSLRDATMEQLEALkgelggt 265
Cdd:COG1577   152 IYYQ-RGDRAEPLELPKNL-PLVVGDTGVPAS-------TKEL-----VAKVRKLKERNPELYEAFLEEIGDL------- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 266 vyrrcayvvqenarVVRACDCLNAGDLEGFGKEMYGSHaGLRDDYEVSCAELDVLVEAAQKApGVFGARMMGGGFGGCTI 345
Cdd:COG1577   211 --------------VEEAIEALEEGDLEALGELMNENH-GLLRALGVSTPELDRLVEAARKA-GALGAKLTGAGGGGCVI 274


                  ...
gi 2216376453 346 NLV 348
Cdd:COG1577   275 ALA 277
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 11-58 3.49e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 82.89  E-value: 3.49e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2216376453  11 ADFQQRFGYAP-LLVRAPGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVG 58
Cdd:pfam10509   1 EAFEELFGKEPvGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVS 49
PRK03926 PRK03926
mevalonate kinase; Provisional
 26-364 1.85e-18

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 85.10  E-value: 1.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  26 APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAVGLNKgDQIRLvahdlnETlELANPAEIAPsdthwanYLlGVAAQLQLR 105
Cdd:PRK03926    6 APGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFND-DSIYI------ES-DYGKTGEKHP-------YV-SAAIEKMRE 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 106 GVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGImDQFASLFGrqGQV 185
Cdd:PRK03926   70 EADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTMG--GFV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 186 VRLDCRSLEYEYFPfdtqaarIVLCNSGVKHSlasseynTRRQecergVSILQQHYEGISSLRDATMEQLealkGELggt 265
Cdd:PRK03926  147 TIPDRKKLPFPECG-------IVVGYTGSSGS-------TKEL-----VANVRKLKEEYPELIEPILSSI----GKI--- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 266 vyrrcayvvqenarVVRACDCLNAGDLEGFGKEMYGSHaGLRDDYEVSCAELDVLVEAAQKApGVFGARMMGGGFGGCTI 345
Cdd:PRK03926  201 --------------SEKGEELILSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGAKITGAGGGGCMV 264

                         330
                  ....*....|....*....
gi 2216376453 346 NLVAPDKVDAFIESVSKAY 364
Cdd:PRK03926  265 ALAAPEKQSEVATAIKIAG 283
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 26-347 8.42e-17

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 79.64  E-value: 8.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  26 APGRVNLIGEHTDYNGGFVLPAAVDKEAVFAV-GLNKGDQIrlvahdlnETLELANPAEIAPSDTHWANYLLGVAAQLQL 104
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTViESSDGSFI--------ESDLGRGSLDDAPDELDGLKYVLAEFLSRFS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 105 RGVAVPgFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGImDQFASLFGRqgq 184
Cdd:TIGR00549  73 ELNPPP-LEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSGG--- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 185 VVRLDCRSLEyeyFPF-DTQAARIVLCNSGVKHSlasseynTRrqECERGVSILQQHYEGISslrDATMEQLEALkgelg 263
Cdd:TIGR00549 148 PVYFEKGEGE---FTKlISLDGYFVIADTGVSGS-------TK--EAVARVRQLLERFPELI---DSIMDAIGEL----- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 264 gtvyrrcayvvqenarVVRACDCLNAGDLEGFGKEMYGSHaGLRDDYEVSCAELDVLVEAAQKApGVFGARMMGGGFGGC 343
Cdd:TIGR00549 208 ----------------TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGGC 269


                  ....
gi 2216376453 344 TINL 347
Cdd:TIGR00549 270 MIAL 273
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 118-181 5.49e-12

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 60.64  E-value: 5.49e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2216376453 118 GTVPLGAGMSSSAAIECGLAFALNQLLDagfekMELARVAQFAEHTYAGVQCGIMDQFASLFGR 181
Cdd:pfam00288   6 SNIPLGAGLGSSAALAVALLLALNELFG-----LPLAKLALEAEELAGGGRGGGMDVAASLYGG 64
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 287-365 1.33e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 45.92  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 287 LNAGDLEGFGKEMYGSHAGL--RDDYEVSCAELDVLVEAAQKApgVFGARMMGGGFGGCTINLVA-PDKVDAFIESVSKA 363
Cdd:pfam08544   5 LLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLEL--GLGAKLSGSGGGPTVFALFKdEDDAEEVARALREA 82


                  ..
gi 2216376453 364 YE 365
Cdd:pfam08544  83 GK 84
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 54-157 1.26e-05

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 46.63  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453  54 VFAVGLNKGDQIRLVAHDLNE---TLELANPAEIaPSDTHwaNyLLGVAAQ--LQLRGVAVPGFDCVFAGTVPLGAGM-S 127
Cdd:COG0083    20 SLGLALSLYDEVEVERSDEPGleiEIEGEGADEL-PTDED--N-LVYQAALalLEKLGKEPPGLRIEIEKGIPLGRGLgS 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 2216376453 128 SSAAIECGLaFALNQLLDAGFEKMELARVA 157
Cdd:COG0083    96 SAAAIVAGL-VAANALLGLPLSKEELLELA 124
COG1829 COG1829
Archaeal pantoate kinase [Coenzyme transport and metabolism]; Archaeal pantoate kinase is part ...
 120-188 2.58e-05

Archaeal pantoate kinase [Coenzyme transport and metabolism]; Archaeal pantoate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441434  Cd Length: 285  Bit Score: 45.65  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2216376453 120 VPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEhtyagVQC--GIMDQFASLFGrqGQVVRL 188
Cdd:COG1829    83 LPLGYGFGVSGAGALGTALALNRALGLGLSSNEAAQIAHEAE-----VEAgtGLGDVVAQAHG--GVVIRL 146
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 275-360 9.05e-04

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 40.99  E-value: 9.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 275 QENARVVRACDCLNAGDLEGFGKEMYGSHAgLRDDYEVSCAELDVLVEAAqKAPGVFGARMMGGGFGGCTINLVA-PDKV 353
Cdd:PTZ00298  222 NYNACVSEAKEALQKGNLFRVGELMNANHD-LCQKLTVSCRELDSIVQTC-RTYGALGAKMSGTGRGGLVVALAAsEDQR 299


                  ....*..
gi 2216376453 354 DAFIESV 360
Cdd:PTZ00298  300 DAIAKAV 306
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 102-209 3.08e-03

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 39.31  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216376453 102 LQLRGVAVPGFDCVFAGTVPLGAGMSSSAAIECGLAFALNQLLDAGFEKMELARVAQFAEHTYAGVQCGIMDQFASLFGR 181
Cdd:TIGR00191  71 LDQLGIRMPPVKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAFVE 150

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2216376453 182 QGQVVRLDCRS-------LEYEYFPFDTQAARIVL 209
Cdd:TIGR00191 151 DDKLEVLKIPIfskldwvLAIPNIEVSTAEARAVL 185
PRK01212 PRK01212
homoserine kinase; Provisional
 120-157 8.08e-03

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 37.82  E-value: 8.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2216376453 120 VPLGAGM-SSSAAIECGLAfALNQLLDAGFEKMELARVA 157
Cdd:PRK01212   90 IPLGRGLgSSAASIVAGLV-AANELAGLPLSKEELLQLA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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