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Conserved domains on  [gi|2216606593|gb|UNC51290|]
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inosine/guanosine kinase [Enterobacter huaxiensis]

Protein Classification

inosine/guanosine kinase( domain architecture ID 10014972)

inosine/guanosine kinase catalyzes the formation of inosine/guanosine monophosphate from inosine or guanosine and ATP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15074 PRK15074
inosine/guanosine kinase; Provisional
 1-434 0e+00

inosine/guanosine kinase; Provisional


:

Pssm-ID: 185033  Cd Length: 434  Bit Score: 1028.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593   1 MKFPGKRKSKHYFPVNARDPLLQQIQPVNETSAAWVVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQEL 80
Cdd:PRK15074    1 MKFPGQRKSKHYFPVNARDPLLQQIQPENETSRTYIVGIDQTLVDIEAKVDDEFLERYGLSKGHSLVIEDDVAEALYQEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  81 VRENLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGGYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLIGESG 160
Cdd:PRK15074   81 KQNNLITHEFAGGTIGNTLHNYSVLADDRSVLLGVMSSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLISEDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 161 ERTFAISPGHMNKLRAESIPEAVIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEWW 240
Cdd:PRK15074  161 ERTFAISPGHMNQLRPESIPEDVIAGASALVLTAYLVRCKPGEPMPEATMKAIEYAKKHNVPVVLTLGTKFVIEDNPQWW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 241 QAFLKEHVSILAMNEEEAEALTGESDPLLASDKALDWVDLVLCTAGPVGLYMAGFTEEESKRKTQHPLLPGAIAEFNQYE 320
Cdd:PRK15074  241 QEFLKEHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGYTEDEAKRETQHPLLPGAIAEFNRYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 321 FSRGMRHKDCTNPLRIYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANAYHKTNVPNSSKHTFSWLTYSSFAQVCKY 400
Cdd:PRK15074  321 FSRAMRKKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALSALLHDITANSYHRSNVPNSSKHKRTYLTYSSLAQVCKY 400

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2216606593 401 ANRVSYQVLNQHSPRLTRGLPEREDSLEEAYWDR 434
Cdd:PRK15074  401 ANRVSYEVLNQHSPRLSRGLPEREDSLEESYWER 434
 
Name Accession Description Interval E-value
PRK15074 PRK15074
inosine/guanosine kinase; Provisional
 1-434 0e+00

inosine/guanosine kinase; Provisional


Pssm-ID: 185033  Cd Length: 434  Bit Score: 1028.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593   1 MKFPGKRKSKHYFPVNARDPLLQQIQPVNETSAAWVVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQEL 80
Cdd:PRK15074    1 MKFPGQRKSKHYFPVNARDPLLQQIQPENETSRTYIVGIDQTLVDIEAKVDDEFLERYGLSKGHSLVIEDDVAEALYQEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  81 VRENLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGGYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLIGESG 160
Cdd:PRK15074   81 KQNNLITHEFAGGTIGNTLHNYSVLADDRSVLLGVMSSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLISEDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 161 ERTFAISPGHMNKLRAESIPEAVIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEWW 240
Cdd:PRK15074  161 ERTFAISPGHMNQLRPESIPEDVIAGASALVLTAYLVRCKPGEPMPEATMKAIEYAKKHNVPVVLTLGTKFVIEDNPQWW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 241 QAFLKEHVSILAMNEEEAEALTGESDPLLASDKALDWVDLVLCTAGPVGLYMAGFTEEESKRKTQHPLLPGAIAEFNQYE 320
Cdd:PRK15074  241 QEFLKEHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGYTEDEAKRETQHPLLPGAIAEFNRYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 321 FSRGMRHKDCTNPLRIYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANAYHKTNVPNSSKHTFSWLTYSSFAQVCKY 400
Cdd:PRK15074  321 FSRAMRKKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALSALLHDITANSYHRSNVPNSSKHKRTYLTYSSLAQVCKY 400

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2216606593 401 ANRVSYQVLNQHSPRLTRGLPEREDSLEEAYWDR 434
Cdd:PRK15074  401 ANRVSYEVLNQHSPRLSRGLPEREDSLEESYWER 434
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 88-425 1.92e-36

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 135.40  E-value: 1.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  88 HQFAGGTIGNTMHNYSVLaDDRSVLLGVMcSNIEIGGYAYRYLcnTSSRTDLNYLQGVDG-PIGRCFTLIGESGERTFAI 166
Cdd:COG0524    32 RRSPGGAAANVAVALARL-GARVALVGAV-GDDPFGDFLLAEL--RAEGVDTSGVRRDPGaPTGLAFILVDPDGERTIVF 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 167 SPGHMNKLRAESIPEAVIAGASALVLTSYLVRckpGEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADN-PEWWQAFLk 245
Cdd:COG0524   108 YRGANAELTPEDLDEALLAGADILHLGGITLA---SEPPREALLAALEAARAAGVPVSLDPNYRPALWEPaRELLRELL- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 246 EHVSILAMNEEEAEALTGESDPLLASDKALDW-VDLVLCTAGPVGLYMagfteeeskrktqhpllpgaiaefnqyeFSRG 324
Cdd:COG0524   184 ALVDILFPNEEEAELLTGETDPEEAAAALLARgVKLVVVTLGAEGALL----------------------------YTGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 325 MRHkdctnplriysHIAPYmggPEKIMNTNGAGDGALAALLHditanayhktnvpnsskhtfSWLTYSSFAQVCKYANRV 404
Cdd:COG0524   236 EVV-----------HVPAF---PVEVVDTTGAGDAFAAGFLA--------------------GLLEGLDLEEALRFANAA 281

                         330       340
                  ....*....|....*....|.
gi 2216606593 405 SYQVLNQHSPRltRGLPERED 425
Cdd:COG0524   282 AALVVTRPGAQ--PALPTREE 300
adenosine_kinase cd01168
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ...
 36-416 1.82e-27

Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.


Pssm-ID: 238573 [Multi-domain]  Cd Length: 312  Bit Score: 111.17  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  36 VVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQelvreNLITHQFAGGTIGNTMHNYSVLaDDRSVLLGv 115
Cdd:cd01168     4 VLGLGNALVDILAQVDDAFLEKLGLKKGDMILADMEEQEELLA-----KLPVKYIAGGSAANTIRGAAAL-GGSAAFIG- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 116 MCSNIEIGGyayRYL-CNTSSRTDLNYLQGVDGPIGRCFTLIGESGERTF----AISpghmNKLRAESIPEAVIAGASAL 190
Cdd:cd01168    77 RVGDDKLGD---FLLkDLRAAGVDTRYQVQPDGPTGTCAVLVTPDAERTMctylGAA----NELSPDDLDWSLLAKAKYL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 191 VLTSYLVrckpgEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEwwqAFLK--EHVSILAMNEEEAEALTG---ES 265
Cdd:cd01168   150 YLEGYLL-----TVPPEAILLAAEHAKENGVKIALNLSAPFIVQRFKE---ALLEllPYVDILFGNEEEAEALAEaetTD 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 266 DPLLASDKALDWVDLVLCTAGPVGLYMAGFTEEEskrktqhpllpgaiaefnqyefsrgmrhkdctnplriysHIAPYmg 345
Cdd:cd01168   222 DLEAALKLLALRCRIVVITQGAKGAVVVEGGEVY---------------------------------------PVPAI-- 260

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2216606593 346 GPEKIMNTNGAGD----GALAALLHDitanayhktnvpnsskhtfswltySSFAQVCKYANRVSYQVLNQHSPRL 416
Cdd:cd01168   261 PVEKIVDTNGAGDafagGFLYGLVQG------------------------EPLEECIRLGSYAAAEVIQQLGPRL 311
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 72-366 4.15e-09

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 57.35  E-value: 4.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  72 VAEALYQELVRENLITHQFAGGTIgNTMHNYSVLADDrSVLLGVmcsnieIGG--YAYRYLCNTSSRT-DLNYLQGVDG- 147
Cdd:pfam00294  15 NVEGLPGELVRVSTVEKGPGGKGA-NVAVALARLGGD-VAFIGA------VGDdnFGEFLLQELKKEGvDTDYVVIDEDt 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 148 PIGRCFTLIGESGERTFAISPGHMNKLRAE--SIPEAVIAGASALVLTSYLVrckpgEPMPEATMKAIEYAKK---YDVP 222
Cdd:pfam00294  87 RTGTALIEVDGDGERTIVFNRGAAADLTPEelEENEDLLENADLLYISGSLP-----LGLPEATLEELIEAAKnggTFDP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 223 VVLtlgtkfviadNPEWwqAFLK------EHVSILAMNEEEAEALTGEsdPLLASDKALDW--------VDLVLCTAGPV 288
Cdd:pfam00294 162 NLL----------DPLG--AAREallellPLADLLKPNEEELEALTGA--KLDDIEEALAAlhkllakgIKTVIVTLGAD 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 289 GLYMAgfteeESKRKTQHPLLPgaiaefnqyefsrgmrhkdctnplriyshiapymggPEKIMNTNGAGD----GALAAL 364
Cdd:pfam00294 228 GALVV-----EGDGEVHVPAVP------------------------------------KVKVVDTTGAGDsfvgGFLAGL 266


                  ..
gi 2216606593 365 LH 366
Cdd:pfam00294 267 LA 268
 
Name Accession Description Interval E-value
PRK15074 PRK15074
inosine/guanosine kinase; Provisional
 1-434 0e+00

inosine/guanosine kinase; Provisional


Pssm-ID: 185033  Cd Length: 434  Bit Score: 1028.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593   1 MKFPGKRKSKHYFPVNARDPLLQQIQPVNETSAAWVVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQEL 80
Cdd:PRK15074    1 MKFPGQRKSKHYFPVNARDPLLQQIQPENETSRTYIVGIDQTLVDIEAKVDDEFLERYGLSKGHSLVIEDDVAEALYQEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  81 VRENLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGGYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLIGESG 160
Cdd:PRK15074   81 KQNNLITHEFAGGTIGNTLHNYSVLADDRSVLLGVMSSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLISEDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 161 ERTFAISPGHMNKLRAESIPEAVIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEWW 240
Cdd:PRK15074  161 ERTFAISPGHMNQLRPESIPEDVIAGASALVLTAYLVRCKPGEPMPEATMKAIEYAKKHNVPVVLTLGTKFVIEDNPQWW 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 241 QAFLKEHVSILAMNEEEAEALTGESDPLLASDKALDWVDLVLCTAGPVGLYMAGFTEEESKRKTQHPLLPGAIAEFNQYE 320
Cdd:PRK15074  241 QEFLKEHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGYTEDEAKRETQHPLLPGAIAEFNRYE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 321 FSRGMRHKDCTNPLRIYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANAYHKTNVPNSSKHTFSWLTYSSFAQVCKY 400
Cdd:PRK15074  321 FSRAMRKKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALSALLHDITANSYHRSNVPNSSKHKRTYLTYSSLAQVCKY 400

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2216606593 401 ANRVSYQVLNQHSPRLTRGLPEREDSLEEAYWDR 434
Cdd:PRK15074  401 ANRVSYEVLNQHSPRLSRGLPEREDSLEESYWER 434
RbsK COG0524
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ...
 88-425 1.92e-36

Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440290 [Multi-domain]  Cd Length: 301  Bit Score: 135.40  E-value: 1.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  88 HQFAGGTIGNTMHNYSVLaDDRSVLLGVMcSNIEIGGYAYRYLcnTSSRTDLNYLQGVDG-PIGRCFTLIGESGERTFAI 166
Cdd:COG0524    32 RRSPGGAAANVAVALARL-GARVALVGAV-GDDPFGDFLLAEL--RAEGVDTSGVRRDPGaPTGLAFILVDPDGERTIVF 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 167 SPGHMNKLRAESIPEAVIAGASALVLTSYLVRckpGEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADN-PEWWQAFLk 245
Cdd:COG0524   108 YRGANAELTPEDLDEALLAGADILHLGGITLA---SEPPREALLAALEAARAAGVPVSLDPNYRPALWEPaRELLRELL- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 246 EHVSILAMNEEEAEALTGESDPLLASDKALDW-VDLVLCTAGPVGLYMagfteeeskrktqhpllpgaiaefnqyeFSRG 324
Cdd:COG0524   184 ALVDILFPNEEEAELLTGETDPEEAAAALLARgVKLVVVTLGAEGALL----------------------------YTGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 325 MRHkdctnplriysHIAPYmggPEKIMNTNGAGDGALAALLHditanayhktnvpnsskhtfSWLTYSSFAQVCKYANRV 404
Cdd:COG0524   236 EVV-----------HVPAF---PVEVVDTTGAGDAFAAGFLA--------------------GLLEGLDLEEALRFANAA 281

                         330       340
                  ....*....|....*....|.
gi 2216606593 405 SYQVLNQHSPRltRGLPERED 425
Cdd:COG0524   282 AALVVTRPGAQ--PALPTREE 300
adenosine_kinase cd01168
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ...
 36-416 1.82e-27

Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.


Pssm-ID: 238573 [Multi-domain]  Cd Length: 312  Bit Score: 111.17  E-value: 1.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  36 VVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQelvreNLITHQFAGGTIGNTMHNYSVLaDDRSVLLGv 115
Cdd:cd01168     4 VLGLGNALVDILAQVDDAFLEKLGLKKGDMILADMEEQEELLA-----KLPVKYIAGGSAANTIRGAAAL-GGSAAFIG- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 116 MCSNIEIGGyayRYL-CNTSSRTDLNYLQGVDGPIGRCFTLIGESGERTF----AISpghmNKLRAESIPEAVIAGASAL 190
Cdd:cd01168    77 RVGDDKLGD---FLLkDLRAAGVDTRYQVQPDGPTGTCAVLVTPDAERTMctylGAA----NELSPDDLDWSLLAKAKYL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 191 VLTSYLVrckpgEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEwwqAFLK--EHVSILAMNEEEAEALTG---ES 265
Cdd:cd01168   150 YLEGYLL-----TVPPEAILLAAEHAKENGVKIALNLSAPFIVQRFKE---ALLEllPYVDILFGNEEEAEALAEaetTD 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 266 DPLLASDKALDWVDLVLCTAGPVGLYMAGFTEEEskrktqhpllpgaiaefnqyefsrgmrhkdctnplriysHIAPYmg 345
Cdd:cd01168   222 DLEAALKLLALRCRIVVITQGAKGAVVVEGGEVY---------------------------------------PVPAI-- 260

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2216606593 346 GPEKIMNTNGAGD----GALAALLHDitanayhktnvpnsskhtfswltySSFAQVCKYANRVSYQVLNQHSPRL 416
Cdd:cd01168   261 PVEKIVDTNGAGDafagGFLYGLVQG------------------------EPLEECIRLGSYAAAEVIQQLGPRL 311
ribokinase_pfkB_like cd00287
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ...
 181-366 3.31e-18

ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).


Pssm-ID: 238177 [Multi-domain]  Cd Length: 196  Bit Score: 82.53  E-value: 3.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 181 EAVIAGASALVLTSYLvrckpgePMPEATMKAIEYAKKYDVPVVLTLGTKFVIADNPEwwQAFLKEHVSILAMNEEEAEA 260
Cdd:cd00287    52 SVTLVGADAVVISGLS-------PAPEAVLDALEEARRRGVPVVLDPGPRAVRLDGEE--LEKLLPGVDILTPNEEEAEA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 261 LTGESDPL------LASDKALDWVDLVLCTAGPVGLYMAGFTEEeskrktqhpllpgaiaefnqyefsrgmrhkdctnpl 334
Cdd:cd00287   123 LTGRRDLEvkeaaeAAALLLSKGPKVVIVTLGEKGAIVATRGGT------------------------------------ 166

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2216606593 335 riYSHIAPYmggPEKIMNTNGAGDGALAALLH 366
Cdd:cd00287   167 --EVHVPAF---PVKVVDTTGAGDAFLAALAA 193
PLN02813 PLN02813
pfkB-type carbohydrate kinase family protein
 36-428 1.69e-10

pfkB-type carbohydrate kinase family protein


Pssm-ID: 215434 [Multi-domain]  Cd Length: 426  Bit Score: 62.52  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  36 VVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDD----VAEAL----YQELvrenlithqfAGGTIGNTMHNYSVLAD 107
Cdd:PLN02813   72 VLGLGQAMVDFSGMVDDEFLERLGLEKGTRKVINHEergkVLRALdgcsYKAS----------AGGSLSNTLVALARLGS 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 108 DRS------VLLGVMCSNIEIGGYaYRylcNTSSRTDLNYLQG--VDGPIGRCFTLIGESGERTFAISPGHMNKLRAESI 179
Cdd:PLN02813  142 QSAagpalnVAMAGSVGSDPLGDF-YR---TKLRRANVHFLSQpvKDGTTGTVIVLTTPDAQRTMLSYQGTSSTVNYDSC 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 180 PEAVIAGASALVLTSYLVRckpgepMP---EATMKAIEYAKKYDVPVVLTLGTKFVIADN-PEWWQAfLKEHVSILAMNE 255
Cdd:PLN02813  218 LASAISKSRVLVVEGYLWE------LPqtiEAIAQACEEAHRAGALVAVTASDVSCIERHrDDFWDV-MGNYADILFANS 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 256 EEAEALTG---ESDPLLASDKALDWVDLVLCTAGPVGLYMagfteeeskrktqhpllpGAIAEFnqyefsrgmrhkdctn 332
Cdd:PLN02813  291 DEARALCGlgsEESPESATRYLSHFCPLVSVTDGARGSYI------------------GVKGEA---------------- 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 333 plrIYshIAPYMGGPekiMNTNGAGDGALAALLHDITANayhktnvpnsskhtfswltYSSFAQVCKYANRVSYQVLNQH 412
Cdd:PLN02813  337 ---VY--IPPSPCVP---VDTCGAGDAYAAGILYGLLRG-------------------VSDLRGMGELAARVAATVVGQQ 389

                         410       420
                  ....*....|....*....|....
gi 2216606593 413 SPRLT--------RGLPEREDSLE 428
Cdd:PLN02813  390 GTRLRvedavelaESFALHLDGSD 413
PfkB pfam00294
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ...
 72-366 4.15e-09

pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases.


Pssm-ID: 425587 [Multi-domain]  Cd Length: 294  Bit Score: 57.35  E-value: 4.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  72 VAEALYQELVRENLITHQFAGGTIgNTMHNYSVLADDrSVLLGVmcsnieIGG--YAYRYLCNTSSRT-DLNYLQGVDG- 147
Cdd:pfam00294  15 NVEGLPGELVRVSTVEKGPGGKGA-NVAVALARLGGD-VAFIGA------VGDdnFGEFLLQELKKEGvDTDYVVIDEDt 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 148 PIGRCFTLIGESGERTFAISPGHMNKLRAE--SIPEAVIAGASALVLTSYLVrckpgEPMPEATMKAIEYAKK---YDVP 222
Cdd:pfam00294  87 RTGTALIEVDGDGERTIVFNRGAAADLTPEelEENEDLLENADLLYISGSLP-----LGLPEATLEELIEAAKnggTFDP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 223 VVLtlgtkfviadNPEWwqAFLK------EHVSILAMNEEEAEALTGEsdPLLASDKALDW--------VDLVLCTAGPV 288
Cdd:pfam00294 162 NLL----------DPLG--AAREallellPLADLLKPNEEELEALTGA--KLDDIEEALAAlhkllakgIKTVIVTLGAD 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 289 GLYMAgfteeESKRKTQHPLLPgaiaefnqyefsrgmrhkdctnplriyshiapymggPEKIMNTNGAGD----GALAAL 364
Cdd:pfam00294 228 GALVV-----EGDGEVHVPAVP------------------------------------KVKVVDTTGAGDsfvgGFLAGL 266


                  ..
gi 2216606593 365 LH 366
Cdd:pfam00294 267 LA 268
ribokinase cd01174
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This ...
 145-363 5.61e-09

Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.


Pssm-ID: 238579 [Multi-domain]  Cd Length: 292  Bit Score: 57.17  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 145 VDGPIGRCFTLIGESGERTFAISPGHMNKLRAESIPEA--VIAGASALVLTsylvrckpGEPMPEATMKAIEYAKKYDVP 222
Cdd:cd01174    86 VGAPTGTAVITVDESGENRIVVVPGANGELTPADVDAAleLIAAADVLLLQ--------LEIPLETVLAALRAARRAGVT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 223 VVLTLGTkfVIADNPEWWqaflkEHVSILAMNEEEAEALTG-----ESDPLLASDKALDW-VDLVLCTAGPVGLYMAgft 296
Cdd:cd01174   158 VILNPAP--ARPLPAELL-----ALVDILVPNETEAALLTGievtdEEDAEKAARLLLAKgVKNVIVTLGAKGALLA--- 227

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 297 eeeskrktqhpllpgaiaefnqyefSRGMRHkdctnplriysHIAPYmggPEKIMNTNGAGD---GALAA 363
Cdd:cd01174   228 -------------------------SGGEVE-----------HVPAF---KVKAVDTTGAGDtfiGALAA 258
PTZ00247 PTZ00247
adenosine kinase; Provisional
 31-369 4.27e-07

adenosine kinase; Provisional


Pssm-ID: 240328 [Multi-domain]  Cd Length: 345  Bit Score: 51.57  E-value: 4.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  31 TSAAWVVGIDQTLVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEaLYQELVRENLITHqFAGGTIGNTMH---------- 100
Cdd:PTZ00247    3 SAPKKLLGFGNPLLDISAHVSDEFLEKYGLELGSAILAEEKQLP-IFEELESIPNVSY-VPGGSALNTARvaqwmlqapk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 101 ---NY-SVLADDR--SVLLGVMcsnieiggyayrylcnTSSRTDLNYLQGVDGPIGRCFTLIGESgERTFAISPGHMNKL 174
Cdd:PTZ00247   81 gfvCYvGCVGDDRfaEILKEAA----------------EKDGVEMLFEYTTKAPTGTCAVLVCGK-ERSLVANLGAANHL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 175 RAESI----PEAVIAGASALVLTSYLVrckpgEPMPEATMKAIEYAKKYDVPVVLTLGTKFVIADnpeWWQAFLK--EHV 248
Cdd:PTZ00247  144 SAEHMqshaVQEAIKTAQLYYLEGFFL-----TVSPNNVLQVAKHARESGKLFCLNLSAPFISQF---FFERLLQvlPYV 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 249 SILAMNEEEAEAltgesdplLASDKALDWVDLVLCTAGPVGLymagfteeeSKRKTQHPLLpgaiAEFNQ-----YEFSR 323
Cdd:PTZ00247  216 DILFGNEEEAKT--------FAKAMKWDTEDLKEIAARIAML---------PKYSGTRPRL----VVFTQgpeptLIATK 274

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2216606593 324 GMRHKDCTNPLriyshiapymgGPEKIMNTNGAGD----GALAALL--HDIT 369
Cdd:PTZ00247  275 DGVTSVPVPPL-----------DQEKIVDTNGAGDafvgGFLAQYAngKDID 315
ribokinase_group_A cd01942
Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ...
 92-289 2.68e-05

Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.


Pssm-ID: 238917 [Multi-domain]  Cd Length: 279  Bit Score: 45.76  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  92 GGTIGNTMHNYSVLaDDRSVLLGVMcSNIEIGGYAYRYLcnTSSRTDLNYLQ-GVDGPIGRCFTLIGESGERTFAISPGH 170
Cdd:cd01942    36 GGSAGNTAVALAKL-GLSPGLVAAV-GEDFHGRLYLEEL--REEGVDTSHVRvVDEDSTGVAFILTDGDDNQIAYFYPGA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 171 MNKLRaESIPEAVIAGASALVLTSylvrckpGEPMPEatmKAIEyAKKYDVPVVLTLGTKFVIADNPEWWQAFlkEHVSI 250
Cdd:cd01942   112 MDELE-PNDEADPDGLADIVHLSS-------GPGLIE---LARE-LAAGGITVSFDPGQELPRLSGEELEEIL--ERADI 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2216606593 251 LAMNEEEAEAL---TGESDPLLASDkaldwVDLVLCTAGPVG 289
Cdd:cd01942   178 LFVNDYEAELLkerTGLSEAELASG-----VRVVVVTLGPKG 214
PLN02379 PLN02379
pfkB-type carbohydrate kinase family protein
 20-267 6.12e-05

pfkB-type carbohydrate kinase family protein


Pssm-ID: 178005 [Multi-domain]  Cd Length: 367  Bit Score: 44.78  E-value: 6.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  20 PLLQQIQPVNETSAAWVVGIDQT-LVDIEAKVDDAFVARYGLSAGHSLVIEDDVAEALYQELVRENLITHQF-------A 91
Cdd:PLN02379    6 CMGAAGALGDGPRPPLVLGLQPVaLVDHVARVDWSLLDQIPGDRGGSIRVTIEELEHILREVNAHILPSPDDlspiktmA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593  92 GGTIGNTMHNYSVLADDRSVLLGVmCSNIEIGGYayrYLCNTS-SRTDLNYLQGVDGPIGRCFTLIGESGERTFAISPGH 170
Cdd:PLN02379   86 GGSVANTIRGLSAGFGVSTGIIGA-CGDDEQGKL---FVSNMGfSGVDLSRLRAKKGPTAQCVCLVDALGNRTMRPCLSS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 171 MNKLRAESIPEAVIAGASALVLtSYLVRckpGEPMPEAtmkAIEYAKKYDVPVVLTLGTKFVIAD-NPEWWQAFLKEHVS 249
Cdd:PLN02379  162 AVKLQADELTKEDFKGSKWLVL-RYGFY---NLEVIEA---AIRLAKQEGLSVSLDLASFEMVRNfRSPLLQLLESGKID 234

                         250       260
                  ....*....|....*....|.
gi 2216606593 250 ILAMNEEEAEALTG---ESDP 267
Cdd:PLN02379  235 LCFANEDEARELLRgeqESDP 255
PRK11142 PRK11142
ribokinase; Provisional
 146-263 3.55e-03

ribokinase; Provisional


Pssm-ID: 236858 [Multi-domain]  Cd Length: 306  Bit Score: 39.08  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216606593 146 DGPIGRCFTLIGESGERTFAISPGHMNKLRAESIP--EAVIAGASALV--LTSylvrckpgePMpEATMKAIEYAKKYDV 221
Cdd:PRK11142   90 GESTGVALIFVNDEGENSIGIHAGANAALTPALVEahRELIANADALLmqLET---------PL-ETVLAAAKIAKQHGT 159

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2216606593 222 PVVLtlgtkfviadNPEWWQAFLKE---HVSILAMNEEEAEALTG 263
Cdd:PRK11142  160 KVIL----------NPAPARELPDEllaLVDIITPNETEAEKLTG 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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