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Conserved domains on  [gi|2198886489|gb|ULQ50888|]
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PQQ-dependent dehydrogenase, methanol/ethanol family [Flavihumibacter fluvii]

Protein Classification

PQQ-binding-like beta-propeller repeat protein( domain architecture ID 29103)

PQQ (pyrroloquinoline quinone)-binding-like beta-propeller repeat protein

Gene Ontology:  GO:0070968
PubMed:  16232604|11831471

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PQQ_DH_like super family cl11493
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 26-521 0e+00

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


The actual alignment was detected with superfamily member cd10277:

Pssm-ID: 472205 [Multi-domain]  Cd Length: 529  Bit Score: 580.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  26 IANADAEPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAPFECTPLVADKIMYISEPPSTVTALDIATG 105
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 106 RKIWTYTPEMPKDVKFMgFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIII 185
Cdd:cd10277    81 KELWKYKHRLPEDIRPC-CDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 186 GISGGEAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNE-TWQGDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPdWNG 264
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAP-WNG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 265 DNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAG 344
Cdd:cd10277   239 DLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTNGKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 345 AAYAKQTWARGLDAK-GRPIVIPGKEPTEKGNLV--YPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPGE 421
Cdd:cd10277   319 TPFVKKITWASIDLKtGRPIYDEDKVPPKKGKTVdfCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKKGA 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 422 YFMGGG-EQLLPGDNASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQ 500
Cdd:cd10277   399 AYLGAGfTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTGSG 478

                         490       500
                  ....*....|....*....|.
gi 2198886489 501 IISNPMSFSVNGQQRVAITAG 521
Cdd:cd10277   479 IIGPPVTWEVDGKQYVAVLSG 499
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 26-521 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 580.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  26 IANADAEPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAPFECTPLVADKIMYISEPPSTVTALDIATG 105
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 106 RKIWTYTPEMPKDVKFMgFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIII 185
Cdd:cd10277    81 KELWKYKHRLPEDIRPC-CDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 186 GISGGEAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNE-TWQGDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPdWNG 264
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAP-WNG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 265 DNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAG 344
Cdd:cd10277   239 DLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTNGKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 345 AAYAKQTWARGLDAK-GRPIVIPGKEPTEKGNLV--YPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPGE 421
Cdd:cd10277   319 TPFVKKITWASIDLKtGRPIYDEDKVPPKKGKTVdfCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKKGA 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 422 YFMGGG-EQLLPGDNASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQ 500
Cdd:cd10277   399 AYLGAGfTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTGSG 478

                         490       500
                  ....*....|....*....|.
gi 2198886489 501 IISNPMSFSVNGQQRVAITAG 521
Cdd:cd10277   479 IIGPPVTWEVDGKQYVAVLSG 499
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
32-529 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 566.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  32 EPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLK-SAGAPFECTPLVADKIMYISEPPSTVTALDIATGRKIWT 110
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGdLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 111 YTPEMPKDVkfMGFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGG 190
Cdd:COG4993    81 YDPKLPDDA--ACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 191 EAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNETWQ-GDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPDWNGDNRKG 269
Cdd:COG4993   159 EFGPRGVVRAYDARTGKLVWRFDTIPDPGEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPDWNGGQRPG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 270 DNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAGAAYAK 349
Cdd:COG4993   239 DNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRETGEPLVTQPFVK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 350 -QTWARGLDAKGR-PIVIPgkePTEKGN--LVYPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPGEYFMG 425
Cdd:COG4993   319 pPNWATEIDMWGAtPIQTP---PSLDGKttLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAPYLG 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 426 GGEQLLPGDN-ASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISN 504
Cdd:COG4993   396 ATLTMYPCPApPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGGQAT 475

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 2198886489 505 PMSFSVNGQQRVAITAG--------------NSLIVFGL 529
Cdd:COG4993   476 PMTYEVDGKQYVAVAAGgggwlglglytpqgDYLIAFAL 514
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 18-521 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 541.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  18 AAQVSYQRIANADAEPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGApFECTPLVADKIMYISEPPSTV 97
Cdd:TIGR03075   3 AAAVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRG-QESQPLVVDGVMYVTTSYSRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  98 TALDIATGRKIWTYTPEMPKDV-KFMGFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAP 176
Cdd:TIGR03075  82 YALDAKTGKILWKYDPKLPDDIiPVMCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 177 VAIDGKIIIGISGGEAGIRGFLDAYNAKTGKLEWRLYTIPG------------KGEPGNETWQGDSWKTGGAPTWVPGSY 244
Cdd:TIGR03075 162 LVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGdmgylkktgkpvGGDPGAKTWPGDAWKTGGGATWGTGSY 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 245 DKELNLLYWGIGNPGPdWNGDNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLAT 324
Cdd:TIGR03075 242 DPETNLIYFGTGNPAP-WNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAH 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 325 ANRNGFYYVLDRKTGEFLAGAAYAK-QTWARGLDAK-GRPIVIPGKEPT--EKGN--LVYPSLQGATNWFSPSYSKSAGL 398
Cdd:TIGR03075 321 ADRNGFFYVLDRTNGKLLSAEPFVDkVNWATGVDLKtGRPIEVPEARSTdgKKGKpvEVCPGFLGGKNWQPMAYSPKTGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 399 FYVSVREMGSLYFKKEVEYKPGEYFMGGGEQLLP-GDNASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSV 477
Cdd:TIGR03075 401 FYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPpPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTL 480

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 2198886489 478 EGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNGQQRVAITAG 521
Cdd:TIGR03075 481 EGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSG 524
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 436-527 2.59e-11

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 63.58  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPpWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPmsfSVNGQQR 515
Cdd:pfam13360   1 ADGVVTALDAATGAELWRVDLETG-LGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP---LVAGGRV 76

                          90
                  ....*....|..
gi 2198886489 516 VAITAGNSLIVF 527
Cdd:pfam13360  77 FVVAGDGSLIAL 88
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 438-505 3.95e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 58.79  E-value: 3.95e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2198886489 438 GAVKALDAATGETKWT--------FRLQSPP--WSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNP 505
Cdd:PRK11138   79 GLVKALDADTGKEIWSvdlsekdgWFSKNKSalLSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKVAGEALSRP 156
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 26-521 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 580.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  26 IANADAEPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAPFECTPLVADKIMYISEPPSTVTALDIATG 105
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 106 RKIWTYTPEMPKDVKFMgFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIII 185
Cdd:cd10277    81 KELWKYKHRLPEDIRPC-CDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 186 GISGGEAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNE-TWQGDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPdWNG 264
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTdTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAP-WNG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 265 DNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAG 344
Cdd:cd10277   239 DLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLDRTNGKLIWA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 345 AAYAKQTWARGLDAK-GRPIVIPGKEPTEKGNLV--YPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPGE 421
Cdd:cd10277   319 TPFVKKITWASIDLKtGRPIYDEDKVPPKKGKTVdfCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKKGA 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 422 YFMGGG-EQLLPGDNASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQ 500
Cdd:cd10277   399 AYLGAGfTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTGSG 478

                         490       500
                  ....*....|....*....|.
gi 2198886489 501 IISNPMSFSVNGQQRVAITAG 521
Cdd:cd10277   479 IIGPPVTWEVDGKQYVAVLSG 499
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
32-529 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 566.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  32 EPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLK-SAGAPFECTPLVADKIMYISEPPSTVTALDIATGRKIWT 110
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGdLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 111 YTPEMPKDVkfMGFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGG 190
Cdd:COG4993    81 YDPKLPDDA--ACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 191 EAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNETWQ-GDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPDWNGDNRKG 269
Cdd:COG4993   159 EFGPRGVVRAYDARTGKLVWRFDTIPDPGEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPDWNGGQRPG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 270 DNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAGAAYAK 349
Cdd:COG4993   239 DNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRETGEPLVTQPFVK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 350 -QTWARGLDAKGR-PIVIPgkePTEKGN--LVYPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPGEYFMG 425
Cdd:COG4993   319 pPNWATEIDMWGAtPIQTP---PSLDGKttLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAPYLG 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 426 GGEQLLPGDN-ASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISN 504
Cdd:COG4993   396 ATLTMYPCPApPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGGQAT 475

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 2198886489 505 PMSFSVNGQQRVAITAG--------------NSLIVFGL 529
Cdd:COG4993   476 PMTYEVDGKQYVAVAAGgggwlglglytpqgDYLIAFAL 514
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 18-521 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 541.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  18 AAQVSYQRIANADAEPGNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGApFECTPLVADKIMYISEPPSTV 97
Cdd:TIGR03075   3 AAAVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRG-QESQPLVVDGVMYVTTSYSRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  98 TALDIATGRKIWTYTPEMPKDV-KFMGFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAP 176
Cdd:TIGR03075  82 YALDAKTGKILWKYDPKLPDDIiPVMCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 177 VAIDGKIIIGISGGEAGIRGFLDAYNAKTGKLEWRLYTIPG------------KGEPGNETWQGDSWKTGGAPTWVPGSY 244
Cdd:TIGR03075 162 LVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGdmgylkktgkpvGGDPGAKTWPGDAWKTGGGATWGTGSY 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 245 DKELNLLYWGIGNPGPdWNGDNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLAT 324
Cdd:TIGR03075 242 DPETNLIYFGTGNPAP-WNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAH 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 325 ANRNGFYYVLDRKTGEFLAGAAYAK-QTWARGLDAK-GRPIVIPGKEPT--EKGN--LVYPSLQGATNWFSPSYSKSAGL 398
Cdd:TIGR03075 321 ADRNGFFYVLDRTNGKLLSAEPFVDkVNWATGVDLKtGRPIEVPEARSTdgKKGKpvEVCPGFLGGKNWQPMAYSPKTGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 399 FYVSVREMGSLYFKKEVEYKPGEYFMGGGEQLLP-GDNASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSV 477
Cdd:TIGR03075 401 FYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPpPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTL 480

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 2198886489 478 EGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNGQQRVAITAG 521
Cdd:TIGR03075 481 EGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSG 524
acido_non_PQQ TIGR04528
acido-empty-quinoprotein group A; Members of this family closely resemble quinoproteins and ...
 36-529 0e+00

acido-empty-quinoprotein group A; Members of this family closely resemble quinoproteins and quinohemoproteins such as PQQ-dependent methanol, glucose, and shikimate dehydrogenases, but restricted to species of Acidobacteria unable to synthesize PQQ. Seven members occur in candidatus Solibacter usitatus Ellin6076, eleven in Acidobacteriaceae bacterium KBS 96, etc. Members have N-terminal signal sequences. They lack the pair of adjacent Cys residues, involved in electron transfer, typical for family TIGR03075, and they lack CxxCH motifs for cytochrome c-like heme-binding. What cofactor these paralogous families of enzymes might use is unclear.


Pssm-ID: 275321  Cd Length: 491  Bit Score: 527.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  36 WLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAP-FECTPLVADKIMYISEPpSTVTALDIATGRKIWTYTPE 114
Cdd:TIGR04528   6 WPTYNGDYSGRRFSPLTQINRANVKSLSLAWAFQTTGGGGGtIKSTPLLVNGILYFTVP-DNVWAVDARTGRQLWHYTWP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 115 mPKDVKFMGfgpvNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGGEAGI 194
Cdd:TIGR04528  85 -PNGGTHIG----NRGVGMYKDWLYFETPDCHLVSLDAKDGKERWDVEIADLKLGYFSTMAPLVVKNHVIVGVSGDDLDV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 195 RGFLDAYNAKTGKLEWRLYTIPGKGEPGNETW-QGDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGPDWNGDNRKGDNLY 273
Cdd:TIGR04528 160 PGFLESRDPETGKLQWRWYTTPKPGEPGSETWpNLDAMAHGGGMTWMTGTYDPELNLYYWGTGNPTPVLAGKGRPGDNLY 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 274 SCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLAGAAYAKQTWA 353
Cdd:TIGR04528 240 TCSIVALNPDTGKLAWYFQPSPHDTHDWDAVETPVLFDGTFDGKPRKLLAQASRNGYFFVLDRTTGKNLLTSPFVDTNWA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 354 RGLDAKGRPIVIPGKEPTEKGNLVYPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEYKPgeYFMGGGEQllpG 433
Cdd:TIGR04528 320 KGIDAKGQPIPNPAKEPAPDGALVSPDSGGATNWPPPSFDPQTGLFYVNAHRSYSIYYLTDPDDKP--EGWGGADY---G 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 434 DNASGAVKALDAATGETKWTFRLQSP-PWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNG 512
Cdd:TIGR04528 395 LWSKSFLEAIDYKTGKIRWTHEWGEGgGGAGVLTTAGGLLFTGDASGNLLALDAATGKTLWHARLGGSVSNGPITYELDG 474

                         490
                  ....*....|....*..
gi 2198886489 513 QQRVAITAGNSLIVFGL 529
Cdd:TIGR04528 475 KQYVLVAAGDTLYAFAL 491
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 34-522 1.57e-155

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 455.18  E-value: 1.57e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  34 GNWLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAPfECTPLVADKIMYISEPPSTVTALDIATGRKIWTYTP 113
Cdd:cd10279     1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTNRGQ-EATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYDP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 114 EMPKDVKFMG-FGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGGEA 192
Cdd:cd10279    80 EVDRESGRKAcCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAEF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 193 GIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNE----------TWQGDSWKTGGAPT-WVPGSYDKELNLLYWGIGNPGPd 261
Cdd:cd10279   160 GVRGYVSAYDAETGKLVWRFYTVPGNPAKPFEhasleaaaatWWTGEWWRTGGGGTvWDSITYDPELDLLYIGTGNGSP- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 262 WNGDNR---KGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKT 338
Cdd:cd10279   239 WNRKVRspgGGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLEIDGKPRKVLMHAPKNGFFYVLDRAT 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 339 GEFLAGAAYAKQTWARGLDAK-GRPIVIPGKEPTEKGNLVYPSLQGATNWFSPSYSKSAGLFYVSVREMGSLYFKKEVEY 417
Cdd:cd10279   319 GKLLSAEPFVPVNWATGIDLKtGRPIENPEARYTKGPKLVFPGPLGAHNWHPMSYNPDTGLVYIPAQEIPAVYEDDPGDF 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 418 K-----------PGEYFMGGGEQLLPGDNASGAVKALDAATGETKWTfRLQSPPWS-GVLSTAGGLVFGGSVEGNFFALD 485
Cdd:cd10279   399 GynplgwntgitPDATPPPAAAKRALRKATRGRLVAWDPVTQKAAWR-VEHPGPWNgGVLATAGNLVFQGTADGELAAYD 477

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2198886489 486 AVTGKSKWQFQTGGQIISNPMSFSVNGQQRVAITAGN 522
Cdd:cd10279   478 ARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGW 514
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 36-521 1.35e-134

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 401.71  E-value: 1.35e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  36 WLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYqlkSAGA--PFECTPLVADKIMYISEP-PSTVTALDIATGRKI-WTY 111
Cdd:cd10278     1 WVMPGKDYANTRYSPLAQINKDNVKNLKVAWTF---STGVlrGHEGAPLVVGDTMYVVTPfPNNVYALDLNDPGKIlWKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 112 TPEM-PKDVKFMGFGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGG 190
Cdd:cd10278    78 KPKQdPSAVAVACCDVVNRGLAYADGKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 191 EAGIRGFLDAYNAKTGKLEWRLYTI------------------PGKGEPGNETWQGDSWKTGGAPTWVPGSYDKELNLLY 252
Cdd:cd10278   158 EFGVRGYVTAYDLKTGKLVWRAYSTgpdkdvligpdfnpfnphDGGKDLGLSTWPGDAWKIGGGTNWGWYSYDPKLNLVY 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 253 WGIGNPGPdWNGDNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYY 332
Cdd:cd10278   238 YGTGNPGP-WNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQTVDGKKRKLLVHFDRNGFVY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 333 VLDRKTGEFLAGAAYAKQTWARGLDAK-GRPIVIPGKEPTEKGNL--VYPSLQGATNWFSPSYSKSAGLFYVSVREMGSL 409
Cdd:cd10278   317 TLDRTTGELLSAEKFDPVNNWKGVDLKtGRPVKDPEKSTHMDHNVtdICPSAMGGKDQQPSSYSPKTGLFYVPTNHLCMD 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 410 YFKKEVEYKPGEYFMGGGEQLLPGDN-ASGAVKALDAATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVT 488
Cdd:cd10278   397 YEPFEVNYTAGQPYVGATLAMYPGPGgHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVDAKT 476

                         490       500       510
                  ....*....|....*....|....*....|...
gi 2198886489 489 GKSKWQFQTGGQIISNPMSFSVNGQQRVAITAG 521
Cdd:cd10278   477 GKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSG 509
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 58-521 2.65e-95

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 296.44  E-value: 2.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  58 NVKRLAPVWIYQLKSAGAPF-ECTPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPKDVKFMGFGPVNRGVALLDN 136
Cdd:cd00216     3 NVFQLTPAWSFSTGDGGNRGsELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGWFEACCDLVNRGVAVWGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 137 NVYIGTLNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAIDGKIIIGISGGEAGIRGFLDAYNAKTGKLEWRLYTIP 216
Cdd:cd00216    83 KVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYLVM 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 217 G-----------KGEPGNETWQGDSWKTGGAPTWVPGSYDKELNLLYWGIGNPGP-DWNGDNRKGDNLYSCSVLAINPTT 284
Cdd:cd00216   163 PdpnllpgkdstVTDRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPwNWGGNRTPGDNLYTSSIVAVNADT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 285 GKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLATANRNGFYYVLDRKTGEFLagaayakqtWARGLDakgrPIv 364
Cdd:cd00216   243 GEMKWQYQTTPHDAWDYDGDNTPVLADIKVKGKKVKVLFAPAKNGNFYVLDRRNGELV---------SARPLV----PD- 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 365 ipgkeptekgnlvypslqgatnwfspSYSKSAGLFYVsvremgslyfkkeveykpgeyfmgggeqllpgdNASGAVKALD 444
Cdd:cd00216   309 --------------------------SYDPDRELFYV---------------------------------PANGRIMALD 329

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2198886489 445 AATGETKWTFRLQSPPWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNGQQRVAITAG 521
Cdd:cd00216   330 PVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDGEQYVLIQAG 406
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 36-529 2.51e-90

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 289.09  E-value: 2.51e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  36 WLTYSGNYAATRYSALNQVNTSNVKRLAPVWIYQLKSAGAP------FECTPLVADKIMYISEPPSTVTALDIATGRKIW 109
Cdd:cd10280     1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPdgnegtFEATPLKVGGTLYLCTPHNRVIALDAATGKELW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 110 TYTPEMPKDVKFMGFgpVNRGVA---------LLDNNVYIGTLNAHLVCLDAKSGA------------IKWNVTVADNKL 168
Cdd:cd10280    81 RFDPKAGADAAPGHQ--TCRGVSywedgaaaaACARRIFFGTGDARLIALDARTGKpcpdfgdngvvdLREGLGRVKPGF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 169 gYAITCAPVAIDGK----IIIGISGGEAGIRGFLDAYNAKTGKLEWRLYTIPGKGEPGNETwqGDSWKT-GGAPTWVPGS 243
Cdd:cd10280   159 -YSSTSPPTVYGDLvivgSAVADNQAVDAPSGVIRAFDVRTGKLVWAFDTIPPPGEAGPDT--AGAWYTrGGPNVWAGMS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 244 YDKELNLLYWGIGNPGPDWNGDNRKGDNLYSCSVLAINPTTGKMAWYFQFTPHDTHDWDANQIPVLLDIKIKGIPRKVLA 323
Cdd:cd10280   236 ADEKLGLVYLPTGSATPDFYGGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKTVPAVA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 324 TANRNGFYYVLDRKTGE-------------------------F----------------LAGAAYAKQTWARGLDAKGR- 361
Cdd:cd10280   316 QPTKQGFVFVLDRRTGKplwpveerpvpqgdvpgertsptqpFptlpppfarqglteddMWGATPFDQLACRIQFRSLRy 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 362 -PIVIPgkePTEKGNLVYPSLQGATNWFSPSYSKSAGLFYVSVREMGSL---------------------YFKKEVEYKP 419
Cdd:cd10280   396 eGLFTP---PSLDGTLIFPGNDGGANWGGAAVDPERGILYVNSNRLPFViqlvprapgdpagvagggeggGGGGGPSPQA 472

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 420 GEYFMGGGEQLLPGDNAS------GAVKALDAATGETKW-----------------TFRLQSPPWSGVLSTAGGLVF-GG 475
Cdd:cd10280   473 GTPYGVGRGRFLSPLGLPcqappwGTLTAIDLNTGKILWqvplgtvpdlgpkgiplPIPTGTPNLGGPVVTAGGLVFiAA 552

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2198886489 476 SVEGNFFALDAVTGKSKWQFQ--TGGQiiSNPMSFSVNGQQRVAITAG----------NSLIVFGL 529
Cdd:cd10280   553 TQDNYLRAFDKATGKELWEARlpAGGQ--ATPMTYEVDGKQYVVIAAGghgslgtkrgDSVIAYAL 616
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 436-527 2.59e-11

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 63.58  E-value: 2.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPpWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPmsfSVNGQQR 515
Cdd:pfam13360   1 ADGVVTALDAATGAELWRVDLETG-LGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP---LVAGGRV 76

                          90
                  ....*....|..
gi 2198886489 516 VAITAGNSLIVF 527
Cdd:pfam13360  77 FVVAGDGSLIAL 88
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 436-527 8.13e-11

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 63.80  E-value: 8.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPPWSGVLStAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPMsfsVNGQQR 515
Cdd:TIGR03300  73 ADGTVAALDAETGKRLWRVDLDERLSGGVGA-DGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPL---VANGLV 148

                          90
                  ....*....|..
gi 2198886489 516 VAITAGNSLIVF 527
Cdd:TIGR03300 149 VVRTNDGRLTAL 160
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 435-527 1.70e-10

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 62.91  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 435 NASGAVKALDAATGETKWTFRLQSPPWSGVlSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPmsfSVNGQQ 514
Cdd:COG1520    64 DADGRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAP---AVAGGR 139

                          90
                  ....*....|...
gi 2198886489 515 RVAITAGNSLIVF 527
Cdd:COG1520   140 VVVRTGDGRVYAL 152
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 438-505 3.95e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 58.79  E-value: 3.95e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2198886489 438 GAVKALDAATGETKWT--------FRLQSPP--WSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNP 505
Cdd:PRK11138   79 GLVKALDADTGKEIWSvdlsekdgWFSKNKSalLSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKVAGEALSRP 156
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 66-168 1.99e-08

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 56.19  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  66 WIYQLKSAGAPF-ECTPLVADKIMYISEPPSTVTALDIATGRKIWTYtpEMPKDVKFMGfgpvnrGVALLDNNVYIGTLN 144
Cdd:cd10276    18 WSKSVGNGGMAGiDLTPVVAGDMVYAADANGQVSAFNATTGKIIWET--SLSGKGFLGG------TPAVGNGKIFVGTES 89

                          90       100
                  ....*....|....*....|....
gi 2198886489 145 AHLVCLDAKSGAIKWNVTVADNKL 168
Cdd:cd10276    90 GYLYALDAKDGSELWRTEVSDSQL 113
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 80-164 2.71e-08

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 55.98  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPkdvkfmgfgpVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKW 159
Cdd:COG1520    52 APAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP----------LSGGVGADGGLVVVGTEDGEVIALDADDGEELW 121


                  ....*
gi 2198886489 160 NVTVA 164
Cdd:COG1520   122 RARLS 126
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 80-212 3.44e-08

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 55.71  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTytpempKDV-KFMGFGPVNR------GVALLDNNVYIGTLNAHLVCLDA 152
Cdd:PRK11138   64 HPAVAYNKVYAADRAGLVKALDADTGKEIWS------VDLsEKDGWFSKNKsallsgGVTVAGGKVYIGSEKGQVYALNA 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 153 KSGAIKWNVTVAdnklGYAITcAPVAidgkiiIGISGGEAGIRGFLDAYNAKTGKLEWRL 212
Cdd:PRK11138  138 EDGEVAWQTKVA----GEALS-RPVV------SDGLVLVHTSNGMLQALNESDGAVKWTV 186
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 71-172 4.26e-08

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 53.95  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  71 KSAGAPFECTPLVADKIMYISEPPSTVTALDIATGRKIWTYtpEMPKDVKFMGfgpVNRGVALLDNNVYIGTLNAHLVCL 150
Cdd:pfam13360  59 QTLSGEVLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWSY--QRSGEPLALR---SSGSPAVVGDTVVAGFSSGKLVAL 133

                          90       100
                  ....*....|....*....|..
gi 2198886489 151 DAKSGAIKWNVTVADNKLGYAI 172
Cdd:pfam13360 134 DPATGKVRWEAPLAAPRGTNEL 155
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 80-210 7.67e-08

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 54.55  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTytpempKDVKfmgfGPVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKW 159
Cdd:TIGR03300  60 QPAVAGGKVYAADADGTVAALDAETGKRLWR------VDLD----ERLSGGVGADGGLVFVGTEKGEVIALDAEDGKELW 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2198886489 160 NvtvadNKLGYAITCAPVAidgkiiIGISGGEAGIRGFLDAYNAKTGKLEW 210
Cdd:TIGR03300 130 R-----AKLSSEVLSPPLV------ANGLVVVRTNDGRLTALDAATGERLW 169
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 436-527 3.21e-07

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 52.51  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPpwsgVLST---AGGLVFGGSVEGNFFALDAVTGKSKWQFQTggqiiSNPmSFSVNG 512
Cdd:COG1520   105 EDGEVIALDADDGEELWRARLSSE----VLAApavAGGRVVVRTGDGRVYALDAATGERLWSYQR-----PVP-ALTLRG 174

                          90
                  ....*....|....*
gi 2198886489 513 QQRVAITAGNSLIVF 527
Cdd:COG1520   175 TSSPVIVGGAVLVGF 189
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 95-163 4.90e-07

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 50.86  E-value: 4.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2198886489  95 STVTALDIATGRKIWTYTPEMPKDVkfmgfgpvnrGVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTV 163
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGG----------GVAVDGGRLFVATGGGQLVALDAATGKLLWRQTL 61
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 435-499 1.54e-06

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 49.32  E-value: 1.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2198886489 435 NASGAVKALDAATGETKWTFRLQSPpWSGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGG 499
Cdd:pfam13360  40 TGGGQLVALDAATGKLLWRQTLSGE-VLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSG 103
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 435-497 1.87e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 50.32  E-value: 1.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2198886489 435 NASGAVKALDAATGETKWTFRLQSPpwsgVLS---TAGGLVFGGSVEGNFFALDAVTGKSKWQFQT 497
Cdd:TIGR03300 112 TEKGEVIALDAEDGKELWRAKLSSE----VLSpplVANGLVVVRTNDGRLTALDAATGERLWTYSR 173
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 81-164 2.51e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 49.81  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  81 PLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPkdvkfmgfgPVN-RG---VALLDNNVYIGTLNAHLVCLDAKSGA 156
Cdd:COG1520   133 PAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVP---------ALTlRGtssPVIVGGAVLVGFANGKLVALDLANGQ 203


                  ....*...
gi 2198886489 157 IKWNVTVA 164
Cdd:COG1520   204 PLWEQRVA 211
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 436-494 4.24e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 49.16  E-value: 4.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPPW----SGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQ 494
Cdd:TIGR03300 153 NDGRLTALDAATGERLWTYSRVTPPLtlrgSASPVIADGGVLVGFAGGKLVALDLQTGQPLWE 215
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 81-164 6.47e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 48.39  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  81 PLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPkdvkfmgfgPVN-RGVA---LLDNNVYIGTLNAHLVCLDAKSGA 156
Cdd:TIGR03300 141 PLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTP---------PLTlRGSAspvIADGGVLVGFAGGKLVALDLQTGQ 211


                  ....*...
gi 2198886489 157 IKWNVTVA 164
Cdd:TIGR03300 212 PLWEQRVA 219
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 436-494 1.03e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 47.89  E-value: 1.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPPWS----GVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQ 494
Cdd:COG1520   145 GDGRVYALDAATGERLWSYQRPVPALTlrgtSSPVIVGGAVLVGFANGKLVALDLANGQPLWE 207
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 276-525 1.30e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 46.63  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 276 SVLAINPTTGKMAWyfQFTPHDTHDWDAnqipvlldikikGIPRKVLATANRNGFYYVLDRKTGeflagaayaKQTWARG 355
Cdd:pfam13360   4 VVTALDAATGAELW--RVDLETGLGGGV------------AVDGGRLFVATGGGQLVALDAATG---------KLLWRQT 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 356 LDAK--GRPIVIPGKE--PTEKGNL-VYPSLQGATNWfspSYSKSAGLFYVSVremgslyfkkeveykPGEYFMGGGEQL 430
Cdd:pfam13360  61 LSGEvlGAPLVAGGRVfvVAGDGSLiALDAADGRRLW---SYQRSGEPLALRS---------------SGSPAVVGDTVV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 431 LPgdNASGAVKALDAATGETKWTFRLQSPPWSGVLST----------AGGLVFGGSVEGNFFALDAVTGKSKWQfqtggQ 500
Cdd:pfam13360 123 AG--FSSGKLVALDPATGKVRWEAPLAAPRGTNELERlvditgtpvvAGGRVFASAYQGRLVAFDAATGRRLWT-----R 195

                         250       260
                  ....*....|....*....|....*
gi 2198886489 501 IISNPMSFSVNGQQRVAITAGNSLI 525
Cdd:pfam13360 196 EISGPNGPILDGDLLYVVSDDGELY 220
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 80-164 1.37e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 46.63  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPK---DVKFMGfgPVNRGVALLDNNVYIGTLNAHLVCLDAKSGA 156
Cdd:pfam13360 113 SPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRgtnELERLV--DITGTPVVAGGRVFASAYQGRLVAFDAATGR 190


                  ....*...
gi 2198886489 157 IKWNVTVA 164
Cdd:pfam13360 191 RLWTREIS 198
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 54-165 3.37e-05

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 45.95  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  54 VNTSNVKRLaPVWIYQLKSAgAPFECTPLVADKImYISEPPSTVTALDIATGRKIWTYTPE------MPKDVKFMGFGPV 127
Cdd:cd09213    65 KGHGSLQRL-PLTIEDLVEA-SPLVSDTNEDDVV-VVGSKRTSVFALDAKTGKIIKTYRADglpstgGSDSDGNSTPGPD 141

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2198886489 128 NrgVALLDNNVYIGTLNAHLVCLDAKSGAIKWNVTVAD 165
Cdd:cd09213   142 E--LQEEEELLYIGRTDYVLQAIDPRSGKELWNVTYGE 177
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 80-159 3.75e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 45.09  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPkdvkfmgfgpvnRGVALLDNNVYIGTLNAHLVCLDAKSGAIKW 159
Cdd:pfam13360 164 TPVVAGGRVFASAYQGRLVAFDAATGRRLWTREISGP------------NGPILDGDLLYVVSDDGELYALDRATGAVVW 231
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 470-505 5.24e-05

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 40.25  E-value: 5.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2198886489 470 GLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNP 505
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 58-167 8.69e-05

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 45.02  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  58 NVKRLAPVWIYQLKSAGapFECTPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEMPKdvkfmGFGPVNRGVALLDNN 137
Cdd:cd10276    96 DAKDGSELWRTEVSDSQ--LLSPPTYADGKIYVGTGDGRLYYCNAETGKVVWNRTSTAPE-----LSLRGGAAPVGAYDV 168

                          90       100       110
                  ....*....|....*....|....*....|
gi 2198886489 138 VYIGTLNAHLVCLDAKSGAIKWNVTVADNK 167
Cdd:cd10276   169 VFVGDGNGTVVALNTGTGVDIWEFSVSEPR 198
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 435-505 1.61e-04

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 43.86  E-value: 1.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2198886489 435 NASGAVKALDAATGETKWTFRLQSPPWSGVLSTAG-GLVFGGSVEGNFFALDAVTGKSKWQFQTG-GQIISNP 505
Cdd:cd10276    45 DANGQVSAFNATTGKIIWETSLSGKGFLGGTPAVGnGKIFVGTESGYLYALDAKDGSELWRTEVSdSQLLSPP 117
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 438-526 2.26e-04

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 42.78  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 438 GAVKALDAATGETKWTFRLQSPPW----SGVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNGQ 513
Cdd:pfam13360  83 GSLIALDAADGRRLWSYQRSGEPLalrsSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVDIT 162

                          90
                  ....*....|...
gi 2198886489 514 QRVAITAGNSLIV 526
Cdd:pfam13360 163 GTPVVAGGRVFAS 175
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 437-529 2.32e-04

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 43.47  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489 437 SGAVKALDAATGETKWTFRLQSppwSGVLS---TAGGLVFGGSVEGNFFALDAVTGKSKWQFQTGGQIISNPMSFSVNGQ 513
Cdd:cd10276    89 SGYLYALDAKDGSELWRTEVSD---SQLLSpptYADGKIYVGTGDGRLYYCNAETGKVVWNRTSTAPELSLRGGAAPVGA 165

                          90
                  ....*....|....*.
gi 2198886489 514 QRVAITAGNSLIVFGL 529
Cdd:cd10276   166 YDVVFVGDGNGTVVAL 181
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 80-159 5.23e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 42.49  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTytpempKDVKfmgfgpVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKW 159
Cdd:COG1520   228 TPVVDGGVVYAVAYQGRLAALDLRSGRVLWS------RDLS------SYTGLAVDGNNLYVTDDDGRVWALDRRNGAELW 295
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 80-159 1.11e-03

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 41.46  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  80 TPLVADKIMYISEPPSTVTALDIATGRKIWTytpempKDVKfmgfgpVNRGVALLDNNVYIGTLNAHLVCLDAKSGAIKW 159
Cdd:TIGR03300 236 DPVVDGGQVYAVSYQGRVAALDLRSGRVLWK------RDAS------SYQGPAVDDNRLYVTDADGVVVALDRRSGSELW 303
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 436-462 1.40e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 36.40  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*..
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPPWS 462
Cdd:pfam01011   8 DDGYLYALDAETGKVLWSFKTGGAVLS 34
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 436-505 2.26e-03

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 40.30  E-value: 2.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2198886489 436 ASGAVKALDAATGETKWTFRLQSPPWS----GVLSTAGGLVFGGSVEGNFFALDAVTGKSKWQfqtggQIISNP 505
Cdd:PRK11138  168 SNGMLQALNESDGAVKWTVNLDVPSLTlrgeSAPATAFGGAIVGGDNGRVSAVLMEQGQLIWQ-----QRISQP 236
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 63-210 2.74e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.69  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2198886489  63 APVWIyqlKSAGAPFECTPLVADKIMYISEPPSTVTALDIATGRKIWTYTPEmpkdvkfmgfGPVNRGVALLDNNVYIGT 142
Cdd:pfam13360  14 AELWR---VDLETGLGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLS----------GEVLGAPLVAGGRVFVVA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2198886489 143 LNAHLVCLDAKSGAIKWNVTVADNKLGYAITCAPVAidgkiiIGISGGEAGIRGFLDAYNAKTGKLEW 210
Cdd:pfam13360  81 GDGSLIALDAADGRRLWSYQRSGEPLALRSSGSPAV------VGDTVVAGFSSGKLVALDPATGKVRW 142
PQQ_3 pfam13570
PQQ-like domain;
448-484 3.27e-03

PQQ-like domain;


Pssm-ID: 463925 [Multi-domain]  Cd Length: 36  Bit Score: 35.26  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2198886489 448 GETKWTFRLQSPPWSGVLsTAGGLVFGGSVEGNFFAL 484
Cdd:pfam13570   1 GEVLWRFETGGPIVSSPA-VAGGLVYVGTGDGTLYAL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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