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Conserved domains on  [gi|2180034257|gb|UJD73467|]
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tetracycline efflux MFS transporter Tet(C) [Cloning vector pET-RA-Y]

Protein Classification

TCR/Tet family MFS transporter( domain architecture ID 13024400)

TCR/Tet family major facilitator superfamily (MFS) transporter functions as a metal-tetracycline/H(+) antiporter that confers tetracycline resistance (TCR) by an active tetracycline efflux

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 2-285 2.24e-131

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 377.75  E-value: 2.24e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESH 81
Cdd:cd17388   101 AGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPL-RAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQA 160
Cdd:cd17388   181 PPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQA 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALT 240
Cdd:cd17388   261 FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLT 340

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2180034257 241 SLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGA 285
Cdd:cd17388   341 SLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 2-285 2.24e-131

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 377.75  E-value: 2.24e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESH 81
Cdd:cd17388   101 AGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPL-RAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQA 160
Cdd:cd17388   181 PPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQA 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALT 240
Cdd:cd17388   261 FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLT 340

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2180034257 241 SLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGA 285
Cdd:cd17388   341 SLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-244 4.44e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.02  E-value: 4.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   6 GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMQESHKGE 84
Cdd:COG2814   113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  85 RRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQlvgqvpaALWVIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTG 164
Cdd:COG2814   193 RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 165 PATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLT 243
Cdd:COG2814   265 RLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344


                  .
gi 2180034257 244 S 244
Cdd:COG2814   345 G 345
MFS_1 pfam07690
Major Facilitator Superfamily;
5-248 1.58e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.81  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGA-ISLHAPFLAAAVLNGLNLLLGCFLMQESHKG 83
Cdd:pfam07690  99 AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  84 ERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAalWVIFGEDRFRWSATMIGLSLAVFGILhALAQAFVT 163
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 164 GPATKRFGEKQAIIAGMAADALGYVLLAFA----TRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 239
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335


                  ....*....
gi 2180034257 240 TSLTSITGP 248
Cdd:pfam07690 336 GSLGGALGP 344
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
135-210 8.36e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 37.35  E-value: 8.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2180034257 135 DRFRWSATMIGLSLAvfgiLHALAQ---AFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG 210
Cdd:PRK11646   39 DQLGWAAVMVGIALG----LRQFIQqglGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGG 113
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 2-285 2.24e-131

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 377.75  E-value: 2.24e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESH 81
Cdd:cd17388   101 AGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPL-RAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQA 160
Cdd:cd17388   181 PPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQA 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALT 240
Cdd:cd17388   261 FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLT 340

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2180034257 241 SLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGA 285
Cdd:cd17388   341 SLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 2-276 2.17e-38

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 138.09  E-value: 2.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI-SLHAPFLAAAVlnglnlllgcflmqes 80
Cdd:cd17330    97 DGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPyGYALPFLVAAA---------------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  81 hkgerrpmpLRAFNPVSSFRWargMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQA 160
Cdd:cd17330   161 ---------LALLNLVLVLFF---LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATR-GWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 239
Cdd:cd17330   229 LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSL 308

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2180034257 240 TSLTSITGPLIVTAIYAASastWNGLAWIVGAALYLV 276
Cdd:cd17330   309 QSLARIIGPLLAGPLYSFL---GPGVPFLLAAGLLLI 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 5-285 3.65e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 108.43  E-value: 3.65e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFLMQESHKG 83
Cdd:cd17325    98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFLVCAALALLALVLALLLLPEPRPP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  84 ERRPMPLRAFNPVSSFRWARGMTIvAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVt 163
Cdd:cd17325   178 PNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA- 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 164 GPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALTSL 242
Cdd:cd17325   256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2180034257 243 TSITGPLIVTAIYAASASTWnglAWIVGAALYLVCLPALRRGA 285
Cdd:cd17325   336 GMVLGPLLGGFLYDAFGFAT---PFLAAAALLLLAAVLFLLLR 375
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 11-278 9.64e-24

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 99.22  E-value: 9.64e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  11 VAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMP 89
Cdd:cd17331   106 AAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLtKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  90 LRAFNPVSSFRWARGMTI-----VAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTG 164
Cdd:cd17331   186 KESASPPSVFNLKEILRLlrlpgVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVG 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 165 PATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG-IGMPALQAMLSRQVDDDHQGQLQGSLAALTSLT 243
Cdd:cd17331   266 PLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGsVLYTVITSLLTKAVPPEDTGTALGLSHALFSLV 345

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2180034257 244 SITGPLIVTAIYAASASTWNGLAWIVGAALYLVCL 278
Cdd:cd17331   346 RTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYL 380
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 1-278 1.66e-17

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 81.56  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGG-LLGAISLHAPFLAAAVLNGLNLLLGCFLMqe 79
Cdd:cd17386   101 LFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGhLFKALGYAWSFSISAALLLIALLYILFFL-- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  80 shkgerrpmplrafnpvssfrwargmTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQ 159
Cdd:cd17386   179 --------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGM 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 160 AFVTGPATKRFGEKQA--IIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLA 237
Cdd:cd17386   233 LGGVLLLRCLLKMSDStlAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLS 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2180034257 238 ALTSLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCL 278
Cdd:cd17386   313 VLESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPV 353
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 6-278 2.17e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 81.08  E-value: 2.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   6 GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGER 85
Cdd:cd17474   102 AGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  86 RPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVgqvpAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGP 165
Cdd:cd17474   182 SSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAF----LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 166 ATKRFGEKQAIIAGMAADALGYVLLAFATR-GWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTS 244
Cdd:cd17474   258 LKKRFGARRILVIGLLLYALSLLLLGFVPSlALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2180034257 245 ITGPLIVTAIYAASASTWnglAWIVGAALYLVCL 278
Cdd:cd17474   338 AVGPLLFGLLLEIFGLSA---PFLVGAAIALAAA 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-244 4.44e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.02  E-value: 4.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   6 GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMQESHKGE 84
Cdd:COG2814   113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  85 RRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQlvgqvpaALWVIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTG 164
Cdd:COG2814   193 RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALF-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 165 PATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLT 243
Cdd:COG2814   265 RLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344


                  .
gi 2180034257 244 S 244
Cdd:COG2814   345 G 345
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-248 7.32e-17

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 79.77  E-value: 7.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIslHAPFLAAAVLNGLNLLLGCFLM--- 77
Cdd:cd17387    96 VSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSES--YGDNLVVLVATIVALLDICFILlav 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  78 QESHKGERRPMPLRAFN------PVSSFRWARGMTIVAALMTVFFIMQL--VGQ---VPAALWVIFGedrfrWSATMIGL 146
Cdd:cd17387   174 PESLPEKMRPASWGAPIsweqadPFASLRKVGKDKTVLLICITVFLSYLpeAGQyssFFVYLKQVMG-----FEYEEVAA 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 147 SLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDD 226
Cdd:cd17387   249 FIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADP 328

                         250       260
                  ....*....|....*....|..
gi 2180034257 227 DHQGQLQGSLAALTSLTSITGP 248
Cdd:cd17387   329 DQQGAVQGMITGIRGLCNGLGP 350
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-276 3.02e-13

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 68.79  E-value: 3.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIS---LHAPFLAAAVLNGLNLLLGCFLm 77
Cdd:cd17390    93 PLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggfYYVALLCSAIFILNAGLVWFLL- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  78 qeshkgerrpmplrafnpvsSFRWargmtivaALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHAL 157
Cdd:cd17390   172 --------------------SKLW--------DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGAL 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 158 AQAFVTGPATKRFGEKQAIIAGMA-ADALGYVLLAFATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDDDHQGQLQGS 235
Cdd:cd17390   224 SGFLVGRILKLYKNNEYLLLLHSFiLLALSLLGLALAPSIWLLVLCLTPLSiSSAVLRTCSTSLLLSRGKSKERGTLLGV 303

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2180034257 236 LAALTSLTSITGPLIVTAIYAASASTwnglAWIVGAALYLV 276
Cdd:cd17390   304 GQSVTSLARILAPLLSGLLQEFSVSG----PGLLGAVLALA 340
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 14-283 1.90e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 66.87  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  14 AYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAF 93
Cdd:cd17329   111 AMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEIL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  94 NPVSSFRWARgmTIVAALMTVFFIMQLVGQVPAALwVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTgPATKRFGEK 173
Cdd:cd17329   191 RGYKIVLRDR--AFLLFLLASFLISLIYFQLESTL-PVYVVEILGLGESLLGLLLALNALLIVLLQFPVA-RLVERFRLR 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 174 QAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG-IGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVT 252
Cdd:cd17329   267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEmLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2180034257 253 AIYAASASTWnglAWIVGAALYLVCLPALRR 283
Cdd:cd17329   347 LLLDLLGPGL---PWLILAALGLIAAALLLG 374
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 5-278 2.18e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.44  E-value: 2.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLmqESHKGE 84
Cdd:cd17473   102 VAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFL--PEPARK 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  85 RRPMPLRAFNPVSSFRWARGMTIVAA---LMTVFFIMQLvgQVPAALwvifgEDRFRWSATMIGLSLAVFGILHALAqAF 161
Cdd:cd17473   180 SKSAASPGAATAAALPWKRVLPIYFLaflAMLLFYVIPI--QLPFLL-----QERGGGSAALIGLALAIASLAGAIG-AL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 162 VTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALT 240
Cdd:cd17473   252 LFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2180034257 241 SLTSITGPLIVTAIYAASASTW--NGLAWIVGAALYLVCL 278
Cdd:cd17473   332 FLGQFLSPLVLGPLVNLTGGLSgaFLILGVLALVLAIVLL 371
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-283 3.39e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 66.10  E-value: 3.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFLMQE 79
Cdd:cd06173   102 LGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  80 SHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGIlHALAQ 159
Cdd:cd06173   182 PPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLG 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 160 AFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAA 238
Cdd:cd06173   261 ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLgLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2180034257 239 LTSLTSITGPLIvtAIYAASASTWNGLAWIVGAALYLVCLPALRR 283
Cdd:cd06173   341 LNSGAMPLGALL--AGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 5-281 1.96e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.60  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI---SLHAPFLAAAVLNGLNLLLGCFLMQESH 81
Cdd:cd06174    98 SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAALALLAAILLLLVVPDPP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPLRAFNPVSSFRWARGMT-IVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQA 160
Cdd:cd06174   178 ESARAKNEEASSKSVLKLLKRVLKNpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 239
Cdd:cd06174   258 LLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLgFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTF 337

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2180034257 240 TSLTSITGPLIVTAIYAASAStwNGLAWIVGAALYLVCLPAL 281
Cdd:cd06174   338 GFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-283 4.45e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.92  E-value: 4.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  13 GAYIADIT-DGEDRARHFGLMSACFGVGMVAGPVAGGLL-------GAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGE 84
Cdd:COG2211   132 SALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPE 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  85 RRPMPLRAFnpVSSFRWARGMTIVAALMTVFFIMQlvgQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAqAFVTG 164
Cdd:COG2211   212 EEKVSLKES--LKALLKNRPFLLLLLAYLLFFLAL---ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG-APLWP 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 165 PATKRFGEKQAIIAGMAADALGYVLLAFATRG--WMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQ-------GQLQG 234
Cdd:COG2211   286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWktgrrreGLYFG 365

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2180034257 235 SLAALTSLTSITGPLIVTAIYAA---------SASTWNGLAW---IVGAALYLVCLPALRR 283
Cdd:COG2211   366 IFTFAIKLGQALAGALAGLLLALfgyvagaaqSPSALTGIRLlffLLPAVLLLLAALLLLF 426
MFS_1 pfam07690
Major Facilitator Superfamily;
5-248 1.58e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.81  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGA-ISLHAPFLAAAVLNGLNLLLGCFLMQESHKG 83
Cdd:pfam07690  99 AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  84 ERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAalWVIFGEDRFRWSATMIGLSLAVFGILhALAQAFVT 163
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 164 GPATKRFGEKQAIIAGMAADALGYVLLAFA----TRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 239
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335


                  ....*....
gi 2180034257 240 TSLTSITGP 248
Cdd:pfam07690 336 GSLGGALGP 344
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 1-278 2.49e-09

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 57.22  E-value: 2.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLH--------------APFLAAAVLN 66
Cdd:cd17326   104 LIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPgyvigiklrfnmytAPAWLMAILG 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  67 GLNLLLGCFLMQEshkgerrpmplrafnpvssfrwargmtivAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSAT---- 142
Cdd:cd17326   184 IINIILILFFFKE-----------------------------VVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREeavl 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 143 MIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLafatrgwMAFPIMILLASgGIGMP----ALQA 218
Cdd:cd17326   235 YNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPignvMLYT 306

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 219 MLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWnglAWIVGAALYLVCL 278
Cdd:cd17326   307 LYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRW---TWIITLGLLLLAI 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-278 1.79e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATG-AVAGAYIADITDGEDRARHFGLMSACFGVG-MVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQ 78
Cdd:COG2223   102 LLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  79 ESHKGERRPMPLRAFNPVSSFRwargmTIVAALMTVFFIMQLVGQVPAALW-VIFGEDRFRWSATMIGLSLAVFGILHAL 157
Cdd:COG2223   182 DPPAGAAAAAKASLRDQLEALR-----DPRFWLLSLLYFGTFGSFIGFSSWlPPYLVDQFGLSAATAGLLAALFALLGAL 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 158 AQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL--ASGGIGMPALQAMLSRQVDDDHQGQLQGS 235
Cdd:COG2223   257 GR-PLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLlgLALGGGNGAVFALVPDIFPTKNAGAVYGL 335

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2180034257 236 LAALTSLTSITGPLIVTAIYAASASTwnGLAWIVGAALYLVCL 278
Cdd:COG2223   336 VGAAGGLGGFLGPLLFGALLDATGSY--TAAFLVFAVLALVAL 376
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 2-271 1.02e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 52.61  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMQES 80
Cdd:cd17490    95 SGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSLFIKEER 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  81 HKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedrfrwSATMIGLSLAVFGILHALAQA 160
Cdd:cd17490   175 REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGA------SSFQLGLLSIIYLLPNALASL 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAAL 239
Cdd:cd17490   249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2180034257 240 TSLTSITGPLIVTAIyaASASTWNGLAWIVGA 271
Cdd:cd17490   329 YALGMFLGPVLVGII--SEAFGLQTGFFVIGV 358
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 5-250 1.73e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESH--K 82
Cdd:cd17489    98 WGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPpvA 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  83 GERRPMPLRAFnpvSSFRWARGMTIVAALMTVFFIMQLVgqvpAALWVIFGEDRFrwsATMIGLSLAVFGILhALAQAFV 162
Cdd:cd17489   178 AEEAEAGTRAF---RRLVEKKVLPPALILFLASIAYGAI----STFLPLYAAERG---ISNAGLFFTVYAIA-LLLSRPF 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 163 TGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHQGQLQGSLAALTS 241
Cdd:cd17489   247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFD 326


                  ....*....
gi 2180034257 242 LTSITGPLI 250
Cdd:cd17489   327 LGIGLGGLL 335
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 10-261 4.64e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 4.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  10 AVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAIS-------LHAPFLAAAVLNGLNLLLGCFLMqeshk 82
Cdd:cd17321   103 PASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFgwrwiflINVPIGLVALLLARTFSGAVLAA----- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  83 gerrpmplrafnpvssfrwargMTIVAALMTVFFIMQLVGQvpaalwvifgeDRFRWSATMIGLSLAVFGILHALAqAFV 162
Cdd:cd17321   178 ----------------------FLLGAALGGLLFLLPLYLQ-----------GVLGYSPLQAGLALLPLALAMLVA-APL 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 163 TGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGM----PALQAMLSRQVDDDHQGQLQGSLAA 238
Cdd:cd17321   224 AGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLglfaTPLTNAALSSVPKEKAGAASGILNT 303

                         250       260
                  ....*....|....*....|...
gi 2180034257 239 LTSLTSITGPLIVTAIYAASAST 261
Cdd:cd17321   304 ARQLGGALGVALLGALLTAGLSA 326
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 14-276 7.31e-07

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 50.19  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  14 AYIADITDGEDRARHFGLMSACFGV-GMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHK--GERRPMPL 90
Cdd:cd17449   147 AYVADVSDRRSRTFRVAVLEACLGLaGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKepKSARLFTT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  91 RAFNPVSSFRWARG----MTIVAALMTVFFIMQLVGQVPAALWVIFG-EDRFRWSATMIGLSLAVfgiLHALAQAFVTGP 165
Cdd:cd17449   227 RHHQSVVRLYVAPApngsRRKLALYSLALFVVVTVHFGAKDLLVLYElSSPLCWDSDLIGYGSAA---EHLTYLSSLLGL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 166 ATKRFGEKQAIIA--GMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLT 243
Cdd:cd17449   304 RLLQLCLEDTWVAeiGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLC 383

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2180034257 244 SITGPLIVTAIYAASASTWNGLAWIVGAALYLV 276
Cdd:cd17449   384 SLVATGIFNSLYPATLHFMKGFPFLFGAALLLI 416
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 6-282 1.10e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 49.50  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   6 GATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAI-SLHAPFLAAAVLNGLNLLLGCFLMQESHKGE 84
Cdd:cd17320   102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFfGWRAIFVFLALLGLLLLLLVLLFLPETLPEE 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  85 RRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedRFRWSATMIGLSLAVFGILHALAqAFVTG 164
Cdd:cd17320   182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIE--QLGLSPAQFGLLFALNAIALILG-SLLNG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 165 PATKRFGEKQAIIAGMAADALGYVLLAFATRG------WMAFPIMILLASGGIGMPALQAMLSrqvddDHQGQLQGSLAA 238
Cdd:cd17320   259 RLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslwPLVAPLFLIFFGFGLIFPNATSLAL-----EPFPHVAGTASA 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2180034257 239 LTSLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALR 282
Cdd:cd17320   334 LLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 14-281 1.30e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 49.08  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  14 AYIADITDGEDRARHFGLMSACFGVGMVAGP-VAGGLLGAISLHAP--FLAAAVLNGLNLLLGCFLMQESHKGERRPMPL 90
Cdd:cd17370   111 ALLADATPPSGRGKAFGLHRALDTLGAVLGPlLAALLLYLLGGNYRtiFLLAAIPALLALLILLFVVKEYPRPPKLRKKS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  91 RAFNPVSSFRWARGMTIVAALMTVffimqlvGQVPAALWVIFGEDRFrWSATMIGLSLAVFGILHALAqAFVTGPATKRF 170
Cdd:cd17370   191 KKTSLKKLPKAFWLYLLAVALFAL-------GNFSFAFLILRAQELG-LSAALIPLLYALFNLVYALA-AYPAGRLSDRI 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 171 GEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLasgGIGMPALQ----AMLSRQVDDDHQGQLQGSLAALTSLTSIT 246
Cdd:cd17370   262 GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW---GLYMGAQEsierAAVADLVPAELRGTAYGLFNTVVGIGWLL 338

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2180034257 247 GPLIVTAIYAASASTWnglAWIVGAALYLVCLPAL 281
Cdd:cd17370   339 ASLIAGYLWDLISPSA---AFLFSAVLALIALLLL 370
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
6-284 1.39e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   6 GATGAVAGAYIADITDgEDRARHFGLMSACFGVGMVAGPVAGGLL----GAISLHAPFLAAAVLNGLNLLLgcFLMQESH 81
Cdd:COG0738   111 GLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLillgLSLSWHLPYLILAVLLLLLALL--FLRSKLP 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMqlvGQVPAALWVI-FGEDRFRWSATMIGLSLAVFGILHALAQa 160
Cdd:COG0738   188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG---AEGAIGDWLPlYLKDVLGLSEATAALGLSLFWGGMTIGR- 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRQVDDDHqgqlqGSLAAL 239
Cdd:COG0738   264 FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlSLMFPTIFSLALDGLGKRT-----AAAVSA 338

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2180034257 240 TSLTSITGPLIVTAIYAASASTWN-GLAWIVGAALYLVCLPALRRG 284
Cdd:COG0738   339 VLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALAL 384
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 134-282 1.79e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 134 EDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIG 212
Cdd:cd06174    23 LQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGsGLI 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 213 MPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALR 282
Cdd:cd06174   102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLL 171
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 5-230 3.07e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.98  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFG----VGMVAGPVAGGLLGAISLhapFLAAAVLNGLNLLLGCFLMQES 80
Cdd:cd17472    97 SGAISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAHLGVSGL---FLITAILSLVSLLILLFFVPDP 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  81 --HKGERRPMPLRAFNPVSSFRWAR----GMTIVAALMTVFFIMQL----VGQVPAALWVIFgedrfrWSATMIGLSLAV 150
Cdd:cd17472   174 pkIVQISEKEKKKLKKLLKNKRLLRldfsIFILHFVLMAFFYILPLlltqLGGGKGQLWKVY------LPAILIGFILMV 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 151 FGILHalaqafvtgpATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPI-MILLASGGIGM-PALQAMLSRQVDDDH 228
Cdd:cd17472   248 PFVIY----------AEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIgLIIFFIGFNLLeALLPSLVSKIAPKEY 317


                  ..
gi 2180034257 229 QG 230
Cdd:cd17472   318 RG 319
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-222 3.24e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   1 MAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLG-AISLHAPFLAAAVLNGLNLLLGCFLMqE 79
Cdd:cd17324    97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIAVLALLAALLLWRLL-P 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  80 SHKGERRPMPLRAFNPVSSFRwaRGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFrwSATMIGLSLAVFGILHALAq 159
Cdd:cd17324   176 SLPPKKPGSLGLLSSLLLLLR--NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF--SSSAIIGLLLLFGVAGVVG- 250

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2180034257 160 AFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSR 222
Cdd:cd17324   251 SPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGfFAAHSALQTRVLR 314
MFS_1 pfam07690
Major Facilitator Superfamily;
111-283 3.69e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 111 LMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLL 190
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 191 AFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIyaASASTWNGLAWIV 269
Cdd:pfam07690  80 LFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--ASLFGWRAAFLIL 157

                         170
                  ....*....|....
gi 2180034257 270 GAALYLVCLPALRR 283
Cdd:pfam07690 158 AILSLLAAVLLLLP 171
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 3-256 6.74e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 6.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   3 GITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFLMQESH 81
Cdd:cd17391   100 GVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLaDLFGIRNVFFITGGLLFLAFLLTLFFVKEDF 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 KGERRPMPLRafnPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWS---ATMIGLSLAVFGILHALA 158
Cdd:cd17391   180 KPVEKKKMVS---TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAsnlAFISGLVFSATGVSSLLS 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 159 qAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGW--MAFPIMILLASGGIgMPALQAMLSRQVDDDHQGQLQGSL 236
Cdd:cd17391   257 -APRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINSLLAKITPKEVAGRIFGYN 334

                         250       260
                  ....*....|....*....|
gi 2180034257 237 AALTSLTSITGPLIVTAIYA 256
Cdd:cd17391   335 QSFQYLGNVAGPLLGSAIAA 354
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
97-281 1.04e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  97 SSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAI 176
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 177 IAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIy 255
Cdd:COG2271    79 AIGLLLWGLATLLFGFATSFWQLLLLRFLLgLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL- 157

                         170       180
                  ....*....|....*....|....*.
gi 2180034257 256 aASASTWNGLAWIVGAALYLVCLPAL 281
Cdd:COG2271   158 -LAAFGWRAAFLILGLPGLLLALLRF 182
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 130-269 1.22e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.30  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 130 VIFGEDRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLasg 209
Cdd:COG2270   262 GIYAAGVLGFSTTELIVFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI--- 337

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2180034257 210 GIGMPALQA----MLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWNGLAWIV 269
Cdd:COG2270   338 GLVMGGIQAlsrsLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLI 401
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 2-283 1.43e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 46.11  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   2 AGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLH---APFLAAAVLNGLNLLL-----G 73
Cdd:cd17389   127 GGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSlgeVFFSMPALFALVLALAdllfiF 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  74 CFLMQESHKGERRpMPLRAFNPVSSFrwaRGMTivaalMTVFFIMQlvgqvpaalwvifgeDRFRWSATMIGLSLAVFGI 153
Cdd:cd17389   207 FFLPETLPSNLRR-LGLVYFLYLFLF---SGLE-----FTLTFLTH---------------QRFQYTSMQQGKMFFFIGI 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 154 LHALAQafvtGPATKRF---GEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLA-SGGIGMPALQAMLSRQVDDDHQ 229
Cdd:cd17389   263 IMALVQ----GGYVRRIkpgKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSfAAATVVPCLTTLVSGYGSDDQK 338

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2180034257 230 GQLQGSLAALTSLTSITGPLIVTAIYAASASTwngLAWIVGAALYLVCLPALRR 283
Cdd:cd17389   339 GTVMGIFRSLGALARALGPIVACTVYWLAGSE---ACYTIGALLFLLPLLLLAR 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
107-283 1.81e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 107 IVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALG 186
Cdd:COG2814    11 ALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 187 YVLLAFATRGWMAFPIMILL-ASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWngl 265
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW--- 165

                         170
                  ....*....|....*...
gi 2180034257 266 AWIVGAALYLVCLPALRR 283
Cdd:COG2814   166 VFLVNAVLALLALLLLLR 183
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 135-278 2.14e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.30  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 135 DRFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFAtRGWMAFPIMILLAS--GGIG 212
Cdd:cd17329    28 QQLGLSASIVGLVLALSAVAGIVA-SLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA-HSPWLFAIALVLTGfgGGLF 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2180034257 213 MPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASAStwngLAWIVGAALYLVCL 278
Cdd:cd17329   106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR----LLFLAAAVLFLLAA 167
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 140-278 3.17e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 140 SATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAM 219
Cdd:cd17330    32 SGYYVGLLQSSYSLGQFLA-SPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAY 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2180034257 220 LSRQVDDDHQGQLQGSLAALTSLTSITGPLIvtaiyAASASTWNGLAW--IVGAALYLVCL 278
Cdd:cd17330   111 IADITDEEERAKAFGIISAAFGLGFILGPAL-----GGFLSTPYGYALpfLVAAALALLNL 166
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 176-276 3.71e-05

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 44.72  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 176 IIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIY 255
Cdd:cd17448   287 VFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIY 366

                          90       100
                  ....*....|....*....|.
gi 2180034257 256 AASASTWNGLAWIVGAALYLV 276
Cdd:cd17448   367 AATVAWFPGFSFLLSAGLCLI 387
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
135-278 2.23e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 135 DRFRWSATMIGLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGM 213
Cdd:COG2223    33 EEFGLSAAQLGLLFAIPVLVGALLRIPL-GFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLgIGGGGSF 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2180034257 214 PALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWNGLAWIVGAALYLVCL 278
Cdd:COG2223   112 AVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
107-282 2.95e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 107 IVAALMTVFFIMQLVGQVPAALWVIFGEDrFRWSATMIGLSLAVFGILHALAqAFVTGPATKRFGEKQAIIAGMAADALG 186
Cdd:COG0738     9 ALIAIYLLFFLWGFATALWGPLIPALKDA-FGLSDAQAGLLLFAFFLGYLLA-SLPAGRLIDRFGYKRGLLLGLLLMALG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 187 YVLLAFATRGWMAFPIMILLASG-GIGMPALQAMLSRqVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASAS-TWNG 264
Cdd:COG0738    87 LLLFALAPSYPLLLLALFLLGLGlGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlSWHL 165

                         170
                  ....*....|....*...
gi 2180034257 265 LAWIVGAALYLVCLPALR 282
Cdd:COG0738   166 PYLILAVLLLLLALLFLR 183
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 140-278 3.34e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 140 SATMIGLSLAVFGILHALAQaFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILL-ASGGIGMPALQA 218
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFS-PPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQgLASAAVWPAAMA 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 219 MLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYAASASTWnglAWIVGAALYLVCL 278
Cdd:cd17325   108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA---PFLVCAALALLAL 164
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
88-283 9.55e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.24  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  88 MPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIfgEDRFRWSATMIGLSLAVFGILHALAqAFVTGPAT 167
Cdd:COG2807     1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEI--RADLGLSATQAGLLTTLPLLAFGLF-APLAPRLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 168 KRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITG 247
Cdd:COG2807    78 RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALA 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2180034257 248 PLIVTAIYAASASTWNGLAWIVGAALYLVC-LPALRR 283
Cdd:COG2807   158 AGLTVPLAAALGWRGALAVWALLALLALLLwLPLLRR 194
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 5-283 1.06e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.25  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   5 TGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGG-LLGAISLHAPFLAAAVLNGLNLllgcflmqeshkg 83
Cdd:cd17503    98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGwLTDNLSWRWIFYINLPIGILAL------------- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  84 errpmplrAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALwVIFGEDRFRWSATMIGLSLAVFGILHALAqAFVT 163
Cdd:cd17503   165 --------LLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLL-PLYLQNVLGYSAFESGLVLAPGGLASAIL-SPLV 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 164 GPATKRFGEKQAIIAGMAADALGYVLLAFAT----RGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQG--------- 230
Cdd:cd17503   235 GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTpdtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGdatalfnti 314

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2180034257 231 -QLQGSL------AALTSLTSITGPLIVTAIYA----ASASTWNGLAWIVGAALYLVCLPALRR 283
Cdd:cd17503   315 rQLGGSIgtallaTLLTNRTQFHHSRLSELLAQqvqkQALIIAFNDAFLVSAILLLVGLLLALF 378
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 3-259 1.12e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.87  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257   3 GITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLL-GAISLHAPFLAAAVLNGLNLLLGCFlmqesh 81
Cdd:cd17504    95 GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIvQHLGWRWIFWTAAPVAVLLAALVPL------ 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  82 kgerrpMPLRAF-NPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGedrfrwsATMIGLSLAVFGILHALAqA 160
Cdd:cd17504   169 ------IDLRLLrRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLG-------ITEAGLLLLPGALVMLIA-G 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 161 FVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGM--PALQAMLSRQVDDDHQGQLQGSLAA 238
Cdd:cd17504   235 PLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLafASLPNIVVESVPPDRTGIATGMNTV 314

                         250       260
                  ....*....|....*....|.
gi 2180034257 239 LTSLTSITGPLIVTAIYAASA 259
Cdd:cd17504   315 LRTIGSAIGPAIAGAILTTYT 335
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 17-224 1.18e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  17 ADITDGEDRARHFGLMSACFGVGMVAGP-VAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMqeshkGERRPMPLRAFNP 95
Cdd:cd17471   115 ADRSSGRDATLFNSVLRAAFSLAWVIGPpLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLL-----PSVKPPAQKATPA 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257  96 VSSFRWARGMTIVAAL--MTVFFIMQLVGQVPAALWVIFGedrfrwsatmIGLSLAVFGILHALAQAF------VTGPAT 167
Cdd:cd17471   190 SSLVKAPVNRRLLLLFaaFTLLFAANSMYIIAMPLYVTNE----------LGGSESWVGLLFGLAAALeipimlLAGLLA 259

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2180034257 168 KRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLA-----SGGIGMPALQAMLSRQV 224
Cdd:cd17471   260 KRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAifigiTAGLGISYFQDLMPGQP 321
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 140-250 2.48e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.13  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 140 SATMIGLSLAVFGILHaLAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAM 219
Cdd:cd17390    29 SPTVIGLIGSVYGALQ-LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAY 107

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2180034257 220 LSRQVDDDHQGQLQGSLAALTSLTSITGPLI 250
Cdd:cd17390   108 LSDLVSEQERSRVLGRFNAASSLGFILGPVV 138
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 136-281 3.02e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 136 RFRWSATMIGLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGM-- 213
Cdd:cd17355    32 EFGWSRAVISLAFTVGLLAFGLAQPFV-GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTla 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2180034257 214 PALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIyaASASTWNGLAWIVGAALYLVCLPAL 281
Cdd:cd17355   111 AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL--IEAFGWRTALLVLALLALLVLVPVL 176
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 131-278 3.89e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.30  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 131 IFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLAS-G 209
Cdd:cd17471    21 LFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSlG 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2180034257 210 GIGMPALQAM---LSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIyaASASTWNGLAWIVgAALYLVCL 278
Cdd:cd17471   101 AAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLL--LDVLGFTGLFLLA-ALLYLVVA 169
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
135-210 8.36e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 37.35  E-value: 8.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2180034257 135 DRFRWSATMIGLSLAvfgiLHALAQ---AFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGG 210
Cdd:PRK11646   39 DQLGWAAVMVGIALG----LRQFIQqglGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGG 113
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 134-213 8.48e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 37.20  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180034257 134 EDRFRWSATMIGLSLAVFGILHALAQAFVtGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGM 213
Cdd:cd17353    30 SSALGWSLASVALAFTLTIVFLAISAPFA-GRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGI 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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