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Conserved domains on  [gi|2161680586|gb|UGB39212|]
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class I SAM-dependent methyltransferase [Frateuria soli]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10008839)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
1-256 4.38e-89

Predicted methyltransferase [General function prediction only];


:

Pssm-ID: 443826  Cd Length: 274  Bit Score: 264.86  E-value: 4.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586   1 MRTLVLAAAIALVLPAAHAAPApqDTAQHAQPPYLAAAINDPGR-QADRADDARRKIAQVMAFAEVKPGDKVLELIPGSG 79
Cdd:COG4798     1 MRRKLLAALAAAALLAAAAAPA--AEAAAAAAAALQAALAGPHRsAADRARDAYRHPAETLAFFGVKPGMTVVEIWPGGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  80 YFTRVFSGVVGPSGHVYAL------WPDEYANEARSDVAnlRKLSKQP-HYANVSV--LTQPAAKLDAPESVDVVFTSQN 150
Cdd:COG4798    79 WYTEILAPYLGPKGKVYAAnfdpdsEPPEYAKRSREAFS--AKLAADPaLYGNVRVtaFAPPDDPIAPPGSADLVLTFRN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 151 YHDypdkFMGEVDPVVLDKQVYKVLKPGGVFIVIDHVAPAGSGMRDTDTLHRIDPAIVRKQAESAGFVFDGQSDALRNPA 230
Cdd:COG4798   157 YHN----WYRAGDAAAMFAAFFKALKPGGVLGVVDHRAPPGTGLEAVATLGYIDEAYVIALAEAAGFELVGESEINANPK 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2161680586 231 DPHDIKVFDKSI----------------RGHTDQFMYRFRKP 256
Cdd:COG4798   233 DTADHPVGVWTLpptlrlgdedrakylaIGESDRMTLKFRKP 274
 
Name Accession Description Interval E-value
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
1-256 4.38e-89

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 264.86  E-value: 4.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586   1 MRTLVLAAAIALVLPAAHAAPApqDTAQHAQPPYLAAAINDPGR-QADRADDARRKIAQVMAFAEVKPGDKVLELIPGSG 79
Cdd:COG4798     1 MRRKLLAALAAAALLAAAAAPA--AEAAAAAAAALQAALAGPHRsAADRARDAYRHPAETLAFFGVKPGMTVVEIWPGGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  80 YFTRVFSGVVGPSGHVYAL------WPDEYANEARSDVAnlRKLSKQP-HYANVSV--LTQPAAKLDAPESVDVVFTSQN 150
Cdd:COG4798    79 WYTEILAPYLGPKGKVYAAnfdpdsEPPEYAKRSREAFS--AKLAADPaLYGNVRVtaFAPPDDPIAPPGSADLVLTFRN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 151 YHDypdkFMGEVDPVVLDKQVYKVLKPGGVFIVIDHVAPAGSGMRDTDTLHRIDPAIVRKQAESAGFVFDGQSDALRNPA 230
Cdd:COG4798   157 YHN----WYRAGDAAAMFAAFFKALKPGGVLGVVDHRAPPGTGLEAVATLGYIDEAYVIALAEAAGFELVGESEINANPK 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2161680586 231 DPHDIKVFDKSI----------------RGHTDQFMYRFRKP 256
Cdd:COG4798   233 DTADHPVGVWTLpptlrlgdedrakylaIGESDRMTLKFRKP 274
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 66-188 1.59e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.42  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  66 KPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpdEYANEArsdVANLRKLSKQPHYANVSVLTQPAAKLD---APESV 142
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGI---DISEEA---IEKARENAQKLGFDNVEFEQGDIEELPellEDDKF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2161680586 143 DVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVA 188
Cdd:pfam13847  76 DVVISNCVLNHIPDP------DKVL-QEILRVLKPGGRLIISDPDS 114
arsM PRK11873
arsenite methyltransferase;
61-188 2.49e-08

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 53.41  E-value: 2.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  61 AFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYAL-WPDEYANEARsdvANLRKLSkqphYANVSVLTQPAAKLDAP 139
Cdd:PRK11873   71 ALAELKPGETVLDLGSGGGFDCFLAARRVGPTGKVIGVdMTPEMLAKAR---ANARKAG----YTNVEFRLGEIEALPVA 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2161680586 140 -ESVDVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVA 188
Cdd:PRK11873  144 dNSVDVIISNCVINLSPDK------ERVF-KEAFRVLKPGGRFAISDVVL 186
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 70-188 8.06e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  70 KVLELIPGSGYFTRVFsgVVGPSGHVYALWPDEYANEArsdvanLRKLSKQPHYANVSVLTQPAAKL--DAPESVDVVFT 147
Cdd:cd02440     1 RVLDLGCGTGALALAL--ASGPGARVTGVDISPVALEL------ARKAAAALLADNVEVLKGDAEELppEADESFDVIIS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2161680586 148 SQNYHDYPDKFMGEVdpvvldKQVYKVLKPGGVFIVIDHVA 188
Cdd:cd02440    73 DPPLHHLVEDLARFL------EEARRLLKPGGVLVLTLVLA 107
 
Name Accession Description Interval E-value
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
1-256 4.38e-89

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 264.86  E-value: 4.38e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586   1 MRTLVLAAAIALVLPAAHAAPApqDTAQHAQPPYLAAAINDPGR-QADRADDARRKIAQVMAFAEVKPGDKVLELIPGSG 79
Cdd:COG4798     1 MRRKLLAALAAAALLAAAAAPA--AEAAAAAAAALQAALAGPHRsAADRARDAYRHPAETLAFFGVKPGMTVVEIWPGGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  80 YFTRVFSGVVGPSGHVYAL------WPDEYANEARSDVAnlRKLSKQP-HYANVSV--LTQPAAKLDAPESVDVVFTSQN 150
Cdd:COG4798    79 WYTEILAPYLGPKGKVYAAnfdpdsEPPEYAKRSREAFS--AKLAADPaLYGNVRVtaFAPPDDPIAPPGSADLVLTFRN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 151 YHDypdkFMGEVDPVVLDKQVYKVLKPGGVFIVIDHVAPAGSGMRDTDTLHRIDPAIVRKQAESAGFVFDGQSDALRNPA 230
Cdd:COG4798   157 YHN----WYRAGDAAAMFAAFFKALKPGGVLGVVDHRAPPGTGLEAVATLGYIDEAYVIALAEAAGFELVGESEINANPK 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2161680586 231 DPHDIKVFDKSI----------------RGHTDQFMYRFRKP 256
Cdd:COG4798   233 DTADHPVGVWTLpptlrlgdedrakylaIGESDRMTLKFRKP 274
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 56-184 1.84e-12

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 65.18  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  56 IAQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYAlwpdeYanEARSDVANLRKlskqphyANVSVLTQPAAk 135
Cdd:COG2519    80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYS-----Y--ERREDFAEIAR-------KNLERFGLPDN- 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2161680586 136 ldapesvdVVFTSQNYHDYPDKfmGEVDPVVLD--------KQVYKVLKPGGVFIVI 184
Cdd:COG2519   145 --------VELKLGDIREGIDE--GDVDAVFLDmpdpwealEAVAKALKPGGVLVAY 191
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 44-196 4.12e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.24  E-value: 4.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  44 RQADRADDARRkiaqVMAFAEVKPGDKVLELIPGSGYFTRVFSGvvgPSGHVYALWPDEYAnearsdVANLRKLSKQPHY 123
Cdd:COG2226     3 RVAARYDGREA----LLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEM------LELARERAAEAGL 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161680586 124 aNVSVLTQPAAKLD-APESVDVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVAPAGSGMRD 196
Cdd:COG2226    70 -NVEFVVGDAEDLPfPDGSFDLVISSFVLHHLPDP------ERAL-AEIARVLKPGGRLVVVDFSPPDLAELEE 135
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 66-188 1.59e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.42  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  66 KPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpdEYANEArsdVANLRKLSKQPHYANVSVLTQPAAKLD---APESV 142
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEVVGI---DISEEA---IEKARENAQKLGFDNVEFEQGDIEELPellEDDKF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2161680586 143 DVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVA 188
Cdd:pfam13847  76 DVVISNCVLNHIPDP------DKVL-QEILRVLKPGGRLIISDPDS 114
arsM PRK11873
arsenite methyltransferase;
61-188 2.49e-08

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 53.41  E-value: 2.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  61 AFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYAL-WPDEYANEARsdvANLRKLSkqphYANVSVLTQPAAKLDAP 139
Cdd:PRK11873   71 ALAELKPGETVLDLGSGGGFDCFLAARRVGPTGKVIGVdMTPEMLAKAR---ANARKAG----YTNVEFRLGEIEALPVA 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2161680586 140 -ESVDVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVA 188
Cdd:PRK11873  144 dNSVDVIISNCVINLSPDK------ERVF-KEAFRVLKPGGRFAISDVVL 186
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 64-218 2.73e-07

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 49.63  E-value: 2.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  64 EVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYAL-WPDEYANEARSdvaNLRKLSkqphYANVSVLTQPAAKLDAPES- 141
Cdd:PRK13942   73 DLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIeRIPELAEKAKK---TLKKLG----YDNVEVIVGDGTLGYEENAp 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161680586 142 VDVVFTSQNYHDYPdkfmgevdpvvldKQVYKVLKPGGVFividhVAPAGSGMRDTDTLHRIDPAIVRKQAESAGFV 218
Cdd:PRK13942  146 YDRIYVTAAGPDIP-------------KPLIEQLKDGGIM-----VIPVGSYSQELIRVEKDNGKIIKKKLGEVAFV 204
PRK08317 PRK08317
hypothetical protein; Provisional
 50-229 3.62e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.94  E-value: 3.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  50 DDARRKIAQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALWPDE-YANEARSDVANLRklskqphyANVSV 128
Cdd:PRK08317    2 PDFRRYRARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEaMLALAKERAAGLG--------PNVEF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 129 LTQPAAKLDAP-ESVDVVFTSQNY---HDyPDKFMGEvdpvvldkqVYKVLKPGGVFIVIDhvapagsgmRDTDTL--HR 202
Cdd:PRK08317   74 VRGDADGLPFPdGSFDAVRSDRVLqhlED-PARALAE---------IARVLRPGGRVVVLD---------TDWDTLvwHS 134

                         170       180
                  ....*....|....*....|....*..
gi 2161680586 203 IDPAIVRKqaesagfVFDGQSDALRNP 229
Cdd:PRK08317  135 GDRALMRK-------ILNFWSDHFADP 154
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 70-188 8.06e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  70 KVLELIPGSGYFTRVFsgVVGPSGHVYALWPDEYANEArsdvanLRKLSKQPHYANVSVLTQPAAKL--DAPESVDVVFT 147
Cdd:cd02440     1 RVLDLGCGTGALALAL--ASGPGARVTGVDISPVALEL------ARKAAAALLADNVEVLKGDAEELppEADESFDVIIS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2161680586 148 SQNYHDYPDKFMGEVdpvvldKQVYKVLKPGGVFIVIDHVA 188
Cdd:cd02440    73 DPPLHHLVEDLARFL------EEARRLLKPGGVLVLTLVLA 107
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 56-190 1.99e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  56 IAQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGpsGHVYALwpdEYANEArsdVANLRKLSKQPHYANVSVLTQPAAK 135
Cdd:COG0500    15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGI---DLSPEA---IALARARAAKAGLGNVEFLVADLAE 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 136 LDA--PESVDVVFTSQNYHDypdkfmgeVDPVVLDK---QVYKVLKPGGVFIVIDHVAPA 190
Cdd:COG0500    87 LDPlpAESFDLVVAFGVLHH--------LPPEEREAllrELARALKPGGVLLLSASDAAA 138
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
57-128 2.06e-06

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 47.36  E-value: 2.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2161680586  57 AQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpdEYANE-ARSDVANLRKLskqpHYANVSV 128
Cdd:pfam01135  63 AMMLELLELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSI---EHIPElVEIARRNLEKL----GLENVIV 128
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 53-195 8.02e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 45.91  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  53 RRKiaqVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALWPdeyaNEARSDVANlRKLSKQPHYANVSVLTQP 132
Cdd:PRK00216   40 RRK---TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTGEVVGLDF----SEGMLAVGR-EKLRDLGLSGNVEFVQGD 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161680586 133 AAKLD-APESVDVV---FTSQNYHDYPDkfmgevdpvVLdKQVYKVLKPGGVFIVIDHVAPAGSGMR 195
Cdd:PRK00216  112 AEALPfPDNSFDAVtiaFGLRNVPDIDK---------AL-REMYRVLKPGGRLVILEFSKPTNPPLK 168
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
53-195 1.01e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 45.51  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  53 RRKIAQVMAfaeVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpDeyANEARSDVAnlRKLSKQPHYANVSVLTQP 132
Cdd:pfam01209  31 KDFTMKCMG---VKRGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGL--D--INENMLKEG--EKKAKEEGKYNIEFLQGN 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2161680586 133 AAKLDAPE-SVDVVFTSQNYHDYPDKfmgevdPVVLdKQVYKVLKPGGVFIVIDHVAPAGSGMR 195
Cdd:pfam01209 102 AEELPFEDdSFDIVTISFGLRNFPDY------LKVL-KEAFRVLKPGGRVVCLEFSKPENPLLS 158
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-179 2.72e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.78  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  71 VLELIPGSGYFTRVFSGVVGpsGHVYALWPDEYAnearsdVANLRKLSKQpHYANVSVLTQPAAKLDAP-ESVDVVFTSQ 149
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEM------LERARERAAE-AGLNVEFVQGDAEDLPFPdGSFDLVVSSG 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 2161680586 150 NYHDYPDKfmgEVDPVVldKQVYKVLKPGG 179
Cdd:pfam13649  72 VLHHLPDP---DLEAAL--REIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 72-183 1.37e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  72 LELIPGSGYFTRVFSGVVGpsgHVYALWPDEYAnearsdVANLRKLSKQPHyanVSVLTQPAAKLD-APESVDVVFTSQN 150
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA---RVTGVDISPEM------LELAREKAPREG---LTFVVGDAEDLPfPDNSFDLVLSSEV 68

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2161680586 151 YH--DYPDKFMGEVdpvvldkqvYKVLKPGGVFIV 183
Cdd:pfam08241  69 LHhvEDPERALREI---------ARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 45-183 1.52e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.39  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  45 QADRADDARRKIAQVMAfAEVKPGDKVLELIPGSGYFTRVFSGvvgpSGH-VYALWPDEYAnearsdVANLRKLSKQphy 123
Cdd:COG2227     3 DPDARDFWDRRLAALLA-RLLPAGGRVLDVGCGTGRLALALAR----RGAdVTGVDISPEA------LEIARERAAE--- 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2161680586 124 ANVSVLTQPAAKLD-APESVDVVFTSQNYHDYPDkfmgevDPVVLdKQVYKVLKPGGVFIV 183
Cdd:COG2227    69 LNVDFVQGDLEDLPlEDGSFDLVICSEVLEHLPD------PAALL-RELARLLKPGGLLLL 122
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 63-218 1.61e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 41.61  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  63 AEVKPGDKVLELIPGSGYFTRVFSGVVgpsGHVYALwpdEY----ANEARsdvANLRKLskqpHYANVSVLTQPAAKLDA 138
Cdd:COG2518    62 LDLKPGDRVLEIGTGSGYQAAVLARLA---GRVYSV---ERdpelAERAR---ERLAAL----GYDNVTVRVGDGALGWP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586 139 PE----------SVDVVftsqnyhdyPDKFMgevdpvvldKQvykvLKPGGVFIVIDHVAPAGSGMRdtdtLHRIDPAIV 208
Cdd:COG2518   129 EHapfdriivtaAAPEV---------PEALL---------EQ----LAPGGRLVAPVGEGGVQRLVL----ITRTGDGFE 182

                         170
                  ....*....|
gi 2161680586 209 RKQAESAGFV 218
Cdd:COG2518   183 RESLFEVRFV 192
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
50-189 4.13e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.40  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  50 DDARRkiaqVMAFAE-----VKPGDKVLELIPGSGyftrVFSGVVGPSG--HVYALwpdEYaNEARSDVANlRKLSKQPH 122
Cdd:COG4076    17 NDVER----NDAFKAaiervVKPGDVVLDIGTGSG----LLSMLAARAGakKVYAV---EV-NPDIAAVAR-RIIAANGL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2161680586 123 YANVSVLTQPAAKLDAPESVDVVFTSQNYHDYPDKFMGevdPVVLD-KQVYkvLKPGGVFI---VIDHVAP 189
Cdd:COG4076    84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQV---PILNHaRKRL--LKPGGRIIperITNAAQP 149
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 46-185 5.26e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.53  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  46 ADRADDARRKIAQVMAFAEVKPGDKVLELipGSG------YFTRVFsGVvgpsgHVYA--LWPDEYAN-EARSDVANLRk 116
Cdd:COG2230    30 DTLEEAQEAKLDLILRKLGLKPGMRVLDI--GCGwgglalYLARRY-GV-----RVTGvtLSPEQLEYaRERAAEAGLA- 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2161680586 117 lskqphyANVSVLTQPAAKLDAPESVDVV--------FTSQNYHDYpdkFmgevdpvvldKQVYKVLKPGGVFIVID 185
Cdd:COG2230   101 -------DRVEVRLADYRDLPADGQFDAIvsigmfehVGPENYPAY---F----------AKVARLLKPGGRLLLHT 157
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
50-180 1.11e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 39.51  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  50 DDARRKIAQVMafaeVKPGDKVLELIPGSGYFTrVFSGVVGpSGHVYALwpdeyanEARSDVANLRKL---SKQPHYANV 126
Cdd:COG2521   119 EDARRKVKLVG----VRRGDRVLDTCTGLGYTA-IEALKRG-AREVITV-------EKDPNVLELAELnpwSRELANERI 185

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2161680586 127 SVLTQPAAKL--DAP-ESVDVVFtsqnyHDyPDKF--MGEVDPVVLDKQVYKVLKPGGV 180
Cdd:COG2521   186 KIILGDASEVikTFPdESFDAII-----HD-PPRFslAGELYSLEFYRELYRVLKPGGR 238
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 56-146 1.14e-03

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 39.40  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  56 IAQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpdEYaNEARSDVAnLRKLSKQPHYANVSVLTQPAAK 135
Cdd:pfam08704  29 ISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTF---EF-HEQRADKA-REEFREHGIDQLVTVTHRDVCK 103

                          90
                  ....*....|....*
gi 2161680586 136 LDAPESV----DVVF 146
Cdd:pfam08704 104 EGFLTEVsgkaDAVF 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
67-183 1.88e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 36.73  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  67 PGDKVLELIPGSGYFTRVFSGVVgPSGHVYALwpdEYANEArsdVANLRKlskqpHYANVSVLTQPAAKLDAPESVDVVF 146
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGV---DLSPEM---LARARA-----RLPNVRFVVADLRDLDPPEPFDLVV 68

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2161680586 147 TSQNYHdypdkFMGEVDPVVldKQVYKVLKPGGVFIV 183
Cdd:COG4106    69 SNAALH-----WLPDHAALL--ARLAAALAPGGVLAV 98
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
56-128 5.72e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 37.11  E-value: 5.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2161680586  56 IAQVMAFAEVKPGDKVLELIPGSGYFTRVFSGVVgpsGHVYALwpDEY---ANEARsdvANLRKLSkqphYANVSV 128
Cdd:PRK00312   67 VARMTELLELKPGDRVLEIGTGSGYQAAVLAHLV---RRVFSV--ERIktlQWEAK---RRLKQLG----LHNVSV 130
PTZ00146 PTZ00146
fibrillarin; Provisional
 65-190 9.85e-03

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 36.63  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2161680586  65 VKPGDKVLELIPGSGYFTRVFSGVVGPSGHVYALwpdEYANEARSDVANLRKlsKQPhyaNVSVLTQPAAKldaPE---- 140
Cdd:PTZ00146  130 IKPGSKVLYLGAASGTTVSHVSDLVGPEGVVYAV---EFSHRSGRDLTNMAK--KRP---NIVPIIEDARY---PQkyrm 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2161680586 141 ---SVDVVFT--SQnyhdyPDkfmgEVDPVVLDKQVYkvLKPGGVFIV------IDHVAPA 190
Cdd:PTZ00146  199 lvpMVDVIFAdvAQ-----PD----QARIVALNAQYF--LKNGGHFIIsikancIDSTAKP 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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