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Conserved domains on  [gi|2158449634|gb|UFQ14056|]
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MbtH family NRPS accessory protein [Streptomyces huasconensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MbtH super family cl01279
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 5-53 2.47e-15

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


The actual alignment was detected with superfamily member smart00923:

Pssm-ID: 470143  Cd Length: 49  Bit Score: 62.59  E-value: 2.47e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2158449634   5 FDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHITR 53
Cdd:smart00923  1 FDDEDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
 
Name Accession Description Interval E-value
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 5-53 2.47e-15

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 62.59  E-value: 2.47e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2158449634   5 FDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHITR 53
Cdd:smart00923  1 FDDEDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-51 6.02e-15

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 61.37  E-value: 6.02e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2158449634  1 MKSAFDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHI 51
Cdd:pfam03621  1 MTNPFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYI 51
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-51 7.39e-14

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 59.11  E-value: 7.39e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2158449634  1 MKSAFDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHI 51
Cdd:COG3251    1 MSNPFDDDDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYI 51
 
Name Accession Description Interval E-value
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 5-53 2.47e-15

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 62.59  E-value: 2.47e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2158449634   5 FDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHITR 53
Cdd:smart00923  1 FDDEDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-51 6.02e-15

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 61.37  E-value: 6.02e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2158449634  1 MKSAFDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHI 51
Cdd:pfam03621  1 MTNPFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYI 51
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-51 7.39e-14

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 59.11  E-value: 7.39e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2158449634  1 MKSAFDREDDLFLVLCGPSGRQALWPSLVPVPQGWQVLHGPAGQAGCLDHI 51
Cdd:COG3251    1 MSNPFDDDDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYI 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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