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Conserved domains on  [gi|1731016685|gb|TYK04490|]
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uncharacterized protein E5676_scaffold409G001040 [Cucumis melo var. makuwa]

Protein Classification

Ac45/VOA1 transmembrane domain-containing protein( domain architecture ID 20804444)

Ac45/VOA1 transmembrane domain-containing protein similar to V-type protein ATPase subunit S1, an accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles

Gene Ontology:  GO:0000220|GO:0070070
PubMed:  18799613

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ac45-VOA1_TM pfam20520
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ...
 296-327 2.83e-06

V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.


:

Pssm-ID: 466669  Cd Length: 39  Bit Score: 43.52  E-value: 2.83e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1731016685 296 LLEGLFVGIVLLIILLSGLCCMMGIDTPTRFE 327
Cdd:pfam20520   7 IWMGLLVSLILLLILYVGLSMLSSLQTYDRFD 38
 
Name Accession Description Interval E-value
Ac45-VOA1_TM pfam20520
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ...
 296-327 2.83e-06

V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.


Pssm-ID: 466669  Cd Length: 39  Bit Score: 43.52  E-value: 2.83e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1731016685 296 LLEGLFVGIVLLIILLSGLCCMMGIDTPTRFE 327
Cdd:pfam20520   7 IWMGLLVSLILLLILYVGLSMLSSLQTYDRFD 38
 
Name Accession Description Interval E-value
Ac45-VOA1_TM pfam20520
V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the ...
 296-327 2.83e-06

V0 complex accessory subunit Ac45/VOA1 transmembrane domain; This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homolog V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.


Pssm-ID: 466669  Cd Length: 39  Bit Score: 43.52  E-value: 2.83e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1731016685 296 LLEGLFVGIVLLIILLSGLCCMMGIDTPTRFE 327
Cdd:pfam20520   7 IWMGLLVSLILLLILYVGLSMLSSLQTYDRFD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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