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Conserved domains on  [gi|1600209692|gb|TEU58735|]
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nuclear transport factor 2 family protein [Burkholderia cepacia]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 10007626)

nuclear transport factor 2 (NTF2) family protein with a SnoaL-like polyketide cyclase domain

CATH:  3.10.450.50
SCOP:  4001306|3000472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
15-130 1.48e-11

Ketosteroid isomerase-related protein [General function prediction only];


:

Pssm-ID: 442849  Cd Length: 126  Bit Score: 57.24  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPFLGWMHP-------EAFFSKVAAASGESKITPIDICVSasgARRATGYFIY 87
Cdd:COG3631     6 VRRFYAAFNAGDVDALLALLAEDVVWEDPGGPGAGTyrgkeavRAFFARLAAAFEDLRFEVRRVVAD---GDRVVVEGTV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1600209692  88 DW-GLKDGSAVRFECVDVFEFDiAGLIERMIIVYDTHPIRSTVG 130
Cdd:COG3631    83 RGtVLATGKPYENRYADVFTVR-DGKIVRVREYFDTAALAAALG 125
 
Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
15-130 1.48e-11

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 57.24  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPFLGWMHP-------EAFFSKVAAASGESKITPIDICVSasgARRATGYFIY 87
Cdd:COG3631     6 VRRFYAAFNAGDVDALLALLAEDVVWEDPGGPGAGTyrgkeavRAFFARLAAAFEDLRFEVRRVVAD---GDRVVVEGTV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1600209692  88 DW-GLKDGSAVRFECVDVFEFDiAGLIERMIIVYDTHPIRSTVG 130
Cdd:COG3631    83 RGtVLATGKPYENRYADVFTVR-DGKIVRVREYFDTAALAAALG 125
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 15-113 1.83e-08

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 48.82  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPFLGWMHPEA---FFSKVAAASGESKITPIDicVSASGARRATGYFIYDWGL 91
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGGPLRGRDAiraFFAALFAAFPDLRFEIHD--VIADGDRVAVRWTVTGTIP 78

                          90       100
                  ....*....|....*....|..
gi 1600209692  92 KDGSAVRFECVDVFEFDiAGLI 113
Cdd:pfam12680  79 PTGRGVRVRGVDVFRFR-DGKI 99
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 15-116 1.36e-05

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 41.64  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPF-----LGWMHPEAFFSKVAAASGESKIT-PIDICVSASGARRATGYFiyD 88
Cdd:cd00781     9 VQRYVEAVNAGDPEGIVALFADDATVEDPVgspprSGRAAIAAFYAQSLGGAKRLELTgPVRASHGGEAAFAFRVEF--E 86

                          90       100
                  ....*....|....*....|....*...
gi 1600209692  89 WGlkdGSAVRFECVDVFEFDIAGLIERM 116
Cdd:cd00781    87 WE---GQPCVVRVIDVMRFDADGRIVSM 111
 
Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
15-130 1.48e-11

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 57.24  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPFLGWMHP-------EAFFSKVAAASGESKITPIDICVSasgARRATGYFIY 87
Cdd:COG3631     6 VRRFYAAFNAGDVDALLALLAEDVVWEDPGGPGAGTyrgkeavRAFFARLAAAFEDLRFEVRRVVAD---GDRVVVEGTV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1600209692  88 DW-GLKDGSAVRFECVDVFEFDiAGLIERMIIVYDTHPIRSTVG 130
Cdd:COG3631    83 RGtVLATGKPYENRYADVFTVR-DGKIVRVREYFDTAALAAALG 125
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 15-113 1.83e-08

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 48.82  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPFLGWMHPEA---FFSKVAAASGESKITPIDicVSASGARRATGYFIYDWGL 91
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGGPLRGRDAiraFFAALFAAFPDLRFEIHD--VIADGDRVAVRWTVTGTIP 78

                          90       100
                  ....*....|....*....|..
gi 1600209692  92 KDGSAVRFECVDVFEFDiAGLI 113
Cdd:pfam12680  79 PTGRGVRVRGVDVFRFR-DGKI 99
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 15-116 1.36e-05

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 41.64  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  15 VRAYLRELERGDVGAICALFTPDAQIFSPF-----LGWMHPEAFFSKVAAASGESKIT-PIDICVSASGARRATGYFiyD 88
Cdd:cd00781     9 VQRYVEAVNAGDPEGIVALFADDATVEDPVgspprSGRAAIAAFYAQSLGGAKRLELTgPVRASHGGEAAFAFRVEF--E 86

                          90       100
                  ....*....|....*....|....*...
gi 1600209692  89 WGlkdGSAVRFECVDVFEFDIAGLIERM 116
Cdd:cd00781    87 WE---GQPCVVRVIDVMRFDADGRIVSM 111
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
13-111 7.36e-05

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 39.74  E-value: 7.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1600209692  13 EQVRAYLRELERGDVGAICALFTPDAQIFSP----FLGWMHPEAFFSKVAAASGESKITPIDICVSASGAR-RATGYFIY 87
Cdd:COG4319    13 ALLAAFAEAFNAGDADALAALYAEDAVFFDPggppVRGREAIRAAWAAAFAAGPRVTFEVEDVRVLVSGDVaVVTGRWRL 92

                          90       100
                  ....*....|....*....|....*.
gi 1600209692  88 DWGLKDGSAVRFE--CVDVFEFDIAG 111
Cdd:COG4319    93 TGTDPDGEPVELAgrYTLVFRKQADG 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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