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Conserved domains on  [gi|1596252165|gb|TDP13468|]
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lipoyl(octanoyl) transferase [Kinneretia asaccharophila]

Protein Classification

lipoate--protein ligase family protein( domain architecture ID 46944)

lipoate--protein ligase family protein, similar to Staphylococcus aureus lipoate--protein ligase 1 and Saccharomyces cerevisiae octanoyltransferase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BPL_LplA_LipB super family cl14057
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), ...
 1-221 6.95e-142

biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), lipoate-protein ligase A (LplA) and octanoyl-[acyl carrier protein]-protein acyltransferase (LipB). Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LplA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes.


The actual alignment was detected with superfamily member PRK14346:

Pssm-ID: 449326  Cd Length: 230  Bit Score: 395.66  E-value: 6.95e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:PRK14346    3 MDRRMLGRVDYLATVQAMQAFTAERTPETPDELWICEHPPVYTQGLAGKADHVLNPGDIPVVATNRGGQVTYHGPGQVVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDPGAHGALSGPADPS------DPFKGLGKIA 154
Cdd:PRK14346   83 YPLIDLRRAGYFVKEYVYRIEEAVIRTLAHFGVTGHRVAGAPGIYVRLDDPFSHAALPQRPQKRgggapqPPFRGLGKIA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1596252165 155 ALGIKVSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQLS 221
Cdd:PRK14346  163 ALGIKVSRHCTYHGVALNVAMDLEPFSRINPCGYAGLQTVDLSTIGVQTTWDEAASVLGQQLARYLA 229
 
Name Accession Description Interval E-value
PRK14346 PRK14346
lipoyl(octanoyl) transferase LipB;
1-221 6.95e-142

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237684  Cd Length: 230  Bit Score: 395.66  E-value: 6.95e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:PRK14346    3 MDRRMLGRVDYLATVQAMQAFTAERTPETPDELWICEHPPVYTQGLAGKADHVLNPGDIPVVATNRGGQVTYHGPGQVVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDPGAHGALSGPADPS------DPFKGLGKIA 154
Cdd:PRK14346   83 YPLIDLRRAGYFVKEYVYRIEEAVIRTLAHFGVTGHRVAGAPGIYVRLDDPFSHAALPQRPQKRgggapqPPFRGLGKIA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1596252165 155 ALGIKVSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQLS 221
Cdd:PRK14346  163 ALGIKVSRHCTYHGVALNVAMDLEPFSRINPCGYAGLQTVDLSTIGVQTTWDEAASVLGQQLARYLA 229
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 1-222 5.65e-107

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 306.65  E-value: 5.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEAR-GPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVV 79
Cdd:COG0321     4 LIIRDLGLVDYEEAWAAQRRLTAARvAGDTPDELWLLEHPPVYTLGRSGKPEHLLAPGGIPVVQTDRGGQITYHGPGQLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  80 AYPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlDDpgahgalsgpadpsdpfkglGKIAALGIK 159
Cdd:COG0321    84 GYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGAPGVWV--DG--------------------RKIAAIGLR 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1596252165 160 VSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLAR-IGVSTDWPEVARRFGERLAAQLSR 222
Cdd:COG0321   142 VRRGVTYHGFALNVNPDLSPFSRIVPCGIADLGVTSLSDeLGRPVTMEEVAEALIRHFAEVFGY 205
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 2-220 1.26e-97

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 282.46  E-value: 1.26e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   2 IVKTLGRVEYAPTEAAMRAFTEARG-PDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:cd16444     1 IVRDLGLIPYEEAWELQKRLVAERIaGETPDTLWLLEHPPVYTLGRRGKPENLLNNGGIPVVRTDRGGQVTYHGPGQLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpgahgalsgpadpsdpfkGLGKIAALGIKV 160
Cdd:cd16444    81 YPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGAPGVWV----------------------GDRKIASIGIRV 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1596252165 161 SRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIG-VSTDWPEVARRFGERLAAQL 220
Cdd:cd16444   139 RRGVTYHGLALNVNTDLSPFNRINPCGIKGKGVTSLSDLGgREVDMEEVKQKLVEEFAKIF 199
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 22-220 7.13e-60

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 186.15  E-value: 7.13e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  22 TEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIP---VVQTNRGGQVTYHGPGQVVAYPLVDLKRLGIFVKEYVF 98
Cdd:TIGR00214   4 TKQRDRQTLDEIMLVEHYPVYTQGQAGKTEHLLFDPDIPpaeVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  99 RLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpGAHgalsgpadpsdpfkglgKIAALGIKVSRHCTYHGAALNVAMDLA 178
Cdd:TIGR00214  84 QLEQTVIITLAELGIEGEPIADATGVWV-----EGK-----------------KVASLGIRVRRGCTFHGLALNINMDLS 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1596252165 179 PFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQL 220
Cdd:TIGR00214 142 PFSHINPCGYAGREMGSLNQFLPGATVENVAPLLIKAFAELL 183
 
Name Accession Description Interval E-value
PRK14346 PRK14346
lipoyl(octanoyl) transferase LipB;
1-221 6.95e-142

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237684  Cd Length: 230  Bit Score: 395.66  E-value: 6.95e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:PRK14346    3 MDRRMLGRVDYLATVQAMQAFTAERTPETPDELWICEHPPVYTQGLAGKADHVLNPGDIPVVATNRGGQVTYHGPGQVVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDPGAHGALSGPADPS------DPFKGLGKIA 154
Cdd:PRK14346   83 YPLIDLRRAGYFVKEYVYRIEEAVIRTLAHFGVTGHRVAGAPGIYVRLDDPFSHAALPQRPQKRgggapqPPFRGLGKIA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1596252165 155 ALGIKVSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQLS 221
Cdd:PRK14346  163 ALGIKVSRHCTYHGVALNVAMDLEPFSRINPCGYAGLQTVDLSTIGVQTTWDEAASVLGQQLARYLA 229
LipB COG0321
Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part ...
 1-222 5.65e-107

Lipoate-protein ligase B [Coenzyme transport and metabolism]; Lipoate-protein ligase B is part of the Pathway/BioSystem: Lipoate biosynthesis


Pssm-ID: 440090  Cd Length: 211  Bit Score: 306.65  E-value: 5.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEAR-GPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVV 79
Cdd:COG0321     4 LIIRDLGLVDYEEAWAAQRRLTAARvAGDTPDELWLLEHPPVYTLGRSGKPEHLLAPGGIPVVQTDRGGQITYHGPGQLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  80 AYPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlDDpgahgalsgpadpsdpfkglGKIAALGIK 159
Cdd:COG0321    84 GYPILDLRRRGLDVRAYVRRLEEAVIDTLAEYGIEAERRPGAPGVWV--DG--------------------RKIAAIGLR 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1596252165 160 VSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLAR-IGVSTDWPEVARRFGERLAAQLSR 222
Cdd:COG0321   142 VRRGVTYHGFALNVNPDLSPFSRIVPCGIADLGVTSLSDeLGRPVTMEEVAEALIRHFAEVFGY 205
PRK14343 PRK14343
lipoyl(octanoyl) transferase LipB;
1-221 9.17e-100

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237682  Cd Length: 235  Bit Score: 289.38  E-value: 9.17e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNP-QGIPVVQTNRGGQVTYHGPGQVV 79
Cdd:PRK14343   15 VTVRWRGREPYEACFDAMRAFTDARTADTPDEIWLVEHPPVYTLGQAGDPAHLLVAdSGIPLVKVDRGGQITYHGPGQVV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  80 AYPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrldDPGAH-GAlsgpadpsdpfkglgKIAALGI 158
Cdd:PRK14343   95 AYLLLDLRRRKLMVRELVTRIEQAVIDTLAAYNLASERKAGAPGIYV---ASGPHqGA---------------KIAALGL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1596252165 159 KVSRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQLS 221
Cdd:PRK14343  157 KIRNGCSYHGLSLNVKMDLRPFLAINPCGYAGLETVDMASLGVAADWADVAQTLARRLIANLD 219
PRK14342 PRK14342
lipoyl(octanoyl) transferase LipB;
1-220 3.92e-98

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237681  Cd Length: 213  Bit Score: 284.08  E-value: 3.92e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   1 MIVKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:PRK14342    6 LIVRQLGLQPYEPVWQAMQEFTDTRDEETPDEIWLVEHPPVFTQGQAGKPEHILNPGDIPVVQSDRGGQVTYHGPGQLVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpgahgalsgpadpsdpfkGLGKIAALGIKV 160
Cdd:PRK14342   86 YVLLDLKRLKLGVRQLVTAIEQTVINTLAEYGIEAHAKPDAPGVYV----------------------DGKKIASLGLRI 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165 161 SRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQL 220
Cdd:PRK14342  144 RRGCSFHGLALNVNMDLSPFLRINPCGYAGLEMTQLSDLGGPATVDEVAPRLLAELLALL 203
LipB cd16444
lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein] ...
 2-220 1.26e-97

lipoyl/octanoyl transferase; Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.


Pssm-ID: 319743  Cd Length: 199  Bit Score: 282.46  E-value: 1.26e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   2 IVKTLGRVEYAPTEAAMRAFTEARG-PDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVA 80
Cdd:cd16444     1 IVRDLGLIPYEEAWELQKRLVAERIaGETPDTLWLLEHPPVYTLGRRGKPENLLNNGGIPVVRTDRGGQVTYHGPGQLVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  81 YPLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpgahgalsgpadpsdpfkGLGKIAALGIKV 160
Cdd:cd16444    81 YPILDLRRRGLDVRRYVRALEEAVIRTLAEYGIEAGRRPGAPGVWV----------------------GDRKIASIGIRV 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1596252165 161 SRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIG-VSTDWPEVARRFGERLAAQL 220
Cdd:cd16444   139 RRGVTYHGLALNVNTDLSPFNRINPCGIKGKGVTSLSDLGgREVDMEEVKQKLVEEFAKIF 199
PRK14349 PRK14349
lipoyl(octanoyl) transferase LipB;
3-222 6.81e-82

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172825  Cd Length: 220  Bit Score: 243.34  E-value: 6.81e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   3 VKTLGR-VEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVAY 81
Cdd:PRK14349    2 IKWLARpADYASVWDAMKAFTAARGPGTADEIWLCEHAPVYTLGQAGRPEHLLNPGLIPVVHCDRGGQVTYHGPGQVLAY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  82 PLVDLKRLGIFVKEYVFRLEAAVIQTLEQFGVTG-HRVAGAPGIYVrlddPGahgalsgpadpsdPFKGLGKIAALGIKV 160
Cdd:PRK14349   82 TLFDLRRAGLYVREYVDMLEQATLATLRELGLEQaCRKPGAPGIYV----PQ-------------PGGELAKIAALGVKV 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1596252165 161 SRHCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEVarrfGERLAAQLSR 222
Cdd:PRK14349  145 RNGYAYHGLALNIDMDLSPFLGINPCGYEGLRTVDLAACGVRTSVERA----GELLAAQLAR 202
lipB TIGR00214
lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the ...
 22-220 7.13e-60

lipoate-protein ligase B; Involved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process). [Protein fate, Protein modification and repair]


Pssm-ID: 272964  Cd Length: 184  Bit Score: 186.15  E-value: 7.13e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  22 TEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQGIP---VVQTNRGGQVTYHGPGQVVAYPLVDLKRLGIFVKEYVF 98
Cdd:TIGR00214   4 TKQRDRQTLDEIMLVEHYPVYTQGQAGKTEHLLFDPDIPpaeVVQSERGGQVTYHGPGQQVMYVILDLKRFQLDVRWLVT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  99 RLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpGAHgalsgpadpsdpfkglgKIAALGIKVSRHCTYHGAALNVAMDLA 178
Cdd:TIGR00214  84 QLEQTVIITLAELGIEGEPIADATGVWV-----EGK-----------------KVASLGIRVRRGCTFHGLALNINMDLS 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1596252165 179 PFRGINPCGYAGLETVDLARIGVSTDWPEVARRFGERLAAQL 220
Cdd:TIGR00214 142 PFSHINPCGYAGREMGSLNQFLPGATVENVAPLLIKAFAELL 183
PRK14341 PRK14341
lipoyl(octanoyl) transferase LipB;
7-208 4.99e-54

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237680  Cd Length: 213  Bit Score: 172.02  E-value: 4.99e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   7 GRVEYAPTEAAMRAFTEARGPDTEDEL-WLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVAYPLVD 85
Cdd:PRK14341   11 GLVPYPEALAFMEARVAAIAAGTADELvWLLEHPPLYTAGTSAKAEDLLDPDRFPVYETGRGGQYTYHGPGQRVAYVMLD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  86 LKRLGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRlddpgahgalsgpadpsDPFKGLG---KIAALGIKVSR 162
Cdd:PRK14341   91 LKRRRRDVRAFVAALEEWIIATLAAFNIRGERREDRVGVWVR-----------------RPDKGSGaedKIAAIGVRLRR 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1596252165 163 HCTYHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPEV 208
Cdd:PRK14341  154 WVSFHGISINVEPDLSHFSGIVPCGISEHGVTSLVDLGLPVTMDDV 199
PRK14345 PRK14345
lipoyl(octanoyl) transferase LipB;
3-221 8.44e-41

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 184638  Cd Length: 234  Bit Score: 138.96  E-value: 8.44e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   3 VKTLGRVEYAPTEAAMRAFTEAR----GPDTedeLWLCEHPPTYTQGLAGQAgHVLNPQGIPVVQTNRGGQVTYHGPGQV 78
Cdd:PRK14345   14 VRRLGLVDYQEAWDLQRELADARvageGPDT---LLLLEHPAVYTAGKRTEP-HERPTDGTPVVDVDRGGKITWHGPGQL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  79 VAYPLVDLKRlGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDPGAHgalsgpadpsdpfkglGKIAALGI 158
Cdd:PRK14345   90 VGYPIIKLAE-PLDVVDYVRRLEEALIAVCADLGLNAGRVDGRSGVWVPADGGRPD----------------RKIAAIGI 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1596252165 159 KVSRHCTYHGAALNVAMDLAPFRGINPCGY--AGLETVDLA---RIGVSTDWPEVARRFGERLAAQLS 221
Cdd:PRK14345  153 RVSRGVTMHGFALNCDNDLAAFDAIVPCGIsdAGVTTLSAElgrTVTVAEVVDPVAAALCDALDGRLP 220
PRK14348 PRK14348
lipoyl(octanoyl) transferase LipB;
23-220 1.44e-36

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172824  Cd Length: 221  Bit Score: 127.83  E-value: 1.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  23 EARGPDTEDELWLCEHPPTYTQGLAGQAGH-VLNPQGIPVVQT-----NRGGQVTYHGPGQVVAYPLVDLKRLGIFVKEY 96
Cdd:PRK14348   31 KQNGESYENRIIFCEHPHVYTLGRSGKENNmLLGEEQLKTIGAtlyhiDRGGDITYHGPGQLVCYPILNLEEFGLGLKEY 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  97 VFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDPGAHgalsgpadpsdpfkglgKIAALGIKVSRHCTYHGAALNVAMD 176
Cdd:PRK14348  111 VHLLEEAVIRVCASYGVVAGRLEKATGVWLEGDTSRAR-----------------KICAIGVRSSHYVTMHGLALNVNTD 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1596252165 177 LAPFRGINPCGYAGLETVDLAR-IGVSTDWPEVARRFGERLAAQL 220
Cdd:PRK14348  174 LRYFSYIHPCGFIDKGVTSLQQeLGHSIDMAEVKERLGRELLAAL 218
PRK14347 PRK14347
lipoyl(octanoyl) transferase LipB;
9-207 1.50e-31

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 172823  Cd Length: 209  Bit Score: 114.26  E-value: 1.50e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   9 VEYAPTEAAMRAFTEARGPDTEDE-LWLCEHPPTYTQGLAGQAGHVLNPQGIPVVQTNRGGQVTYHGPGQVVAYPLVDLK 87
Cdd:PRK14347   11 ADYQVTLKLMEDYVNKVISDHEPEiVYLVEHSEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQRVIYPILNLA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  88 RLGIF--VKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVRLDDpgahgalsgpadpsDPFkglGKIAALGIKVSRHCT 165
Cdd:PRK14347   91 SPNRHkdLKLYIKMLEEWIINSLNYFGIKAYIIKDKVGIWVKVRK--------------DEF---AKIAAIGVRVRKWVT 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1596252165 166 YHGAALNVAMDLAPFRGINPCGYAGLETVDLARIGVSTDWPE 207
Cdd:PRK14347  154 YHGVAINISTDLSKFSGIIPCGLENSLVTSLNQLGIHVEMSE 195
PRK14344 PRK14344
lipoyl(octanoyl) transferase LipB;
26-205 1.74e-30

lipoyl(octanoyl) transferase LipB;


Pssm-ID: 237683  Cd Length: 223  Bit Score: 112.08  E-value: 1.74e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  26 GPDTEDELWLCEHPPTYTQGLAGQAGHVL---NPQGIPVVQTNRGGQVTYHGPGQVVAYPLVDLKRLGIFVKEYVFRLEA 102
Cdd:PRK14344   46 DPSNPQAVWLLEHQLCYTLGRGASEDNLLfslNNPPADVFRIDRGGEVTHHMPGQLVTYLVLDLRRFNKDLNWYLRQLEQ 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165 103 AVIQTLEQFGVTGHRVAGAPGIYVrlddpgahgalsgpadpsdpfkGLGKIAALGIKVSRHCTYHGAALNVAMDLAPFRG 182
Cdd:PRK14344  126 VLIDVLADLGIDGERLDGLTGVWI----------------------GNKKVASIGIGCRRWITQHGFSLNVDCDLEGFNK 183

                         170       180
                  ....*....|....*....|...
gi 1596252165 183 INPCGYAGLETVDLArigvstDW 205
Cdd:PRK14344  184 IVPCGLEGCQVGRLS------DW 200
BPL_LplA_LipB cd16435
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), ...
 3-190 7.96e-19

biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), lipoate-protein ligase A (LplA) and octanoyl-[acyl carrier protein]-protein acyltransferase (LipB). Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LplA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes.


Pssm-ID: 319740  Cd Length: 198  Bit Score: 80.66  E-value: 7.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165   3 VKTLGRVEYAPTEAAMRAFTEARGPDTEDELWLCEHPPTYTQGLAGQAGHVLNPQ-----GIPVVQTNRGGQVTYHGPGQ 77
Cdd:cd16435     2 VEVLDSVDYESAWAAQEKSLRENVSNQSSTLLLWEHPTTVTLGRLDRELPHLELAkkierGYELVVRNRGGRAVSHDPGQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1596252165  78 VVAYPLVDLKRlGIFVKEYVFRLEAAVIQTLEQFGVTGHRVAGAPGIYVrlddpgahgalsgpadpsdpfkGLGKIAALG 157
Cdd:cd16435    82 LVFSPVIGPNV-EFMISKFNLIIEEGIRDAIADFGQSAEVKWGRNDLWI----------------------DNRKVCGIA 138

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1596252165 158 IKVSRHCTYHGAALNVAMDLAPFRGINPCGYAG 190
Cdd:cd16435   139 VRVVKEAIFHGIALNLNQDLENFTEIIPCGYKP 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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