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Conserved domains on  [gi|7506591|gb|T15273|]
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hypothetical protein R10F2.2 - Caenorhabditis elegans

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 217-307 1.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  217 YTASVSANISIGSHLITVQATDADIGENSRISYDIkkTSAPSNSNFAI-SQSGVITTTASL--LPASTHDVIVVASDHGS 293
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIdPSTGEITTAKPLdrEEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 7506591  294 PSLSSSAVVTITVL 307
Cdd:cd11304  80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 108-208 1.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  108 LEISEFAQLGTSFALPTVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDG 187
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI------DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 7506591  188 GKPAKIGQLRCSIEIIDANDN 208
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 438-511 3.81e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 3.81e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7506591  438 TLTAKDPDLGQNGWIRYSVL---DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLLD 511
Cdd:cd11304  18 TVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 39-99 2.18e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 2.18e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591      39 VDISEENIFlKVDERSGEISTIAHLDYEKRSKFDIVaVKVEESGE-----TIDILVEVDDENDNAP 99
Cdd:smart00112  18 LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLT-VEATDGGGpplssTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 217-307 1.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  217 YTASVSANISIGSHLITVQATDADIGENSRISYDIkkTSAPSNSNFAI-SQSGVITTTASL--LPASTHDVIVVASDHGS 293
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIdPSTGEITTAKPLdrEEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 7506591  294 PSLSSSAVVTITVL 307
Cdd:cd11304  80 PPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
217-307 8.49e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 8.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591    217 YTASVSANISIGSHLITVQATDADIGENSRISYDIKKTsaPSNSNFAISQ-SGVITTTASL--LPASTHDVIVVASDHGS 293
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPdTGDISTTKPLdrESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 7506591    294 PSLSSSAVVTITVL 307
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 108-208 1.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  108 LEISEFAQLGTSFALPTVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDG 187
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI------DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 7506591  188 GKPAKIGQLRCSIEIIDANDN 208
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 124-210 2.72e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591     124 TVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDGGKPAKIGQLRCSIEII 203
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI------DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 7506591     204 DANDNAP 210
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 438-511 3.81e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 3.81e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7506591  438 TLTAKDPDLGQNGWIRYSVL---DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLLD 511
Cdd:cd11304  18 TVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 235-307 6.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 6.27e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591     235 QATDADIGENSRISYDIkkTSAPSNSNFAI-SQSGVITTTASLL--PASTHDVIVVASDHGSPSLSSSAVVTITVL 307
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIdPETGEITTTKPLDreEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 440-517 7.70e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 7.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591     440 TAKDPDLGQNGWIRYSVL---DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLLDTESKP 516
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 7506591     517 P 517
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
109-203 2.64e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591    109 EISEFAQLGTSFALPTVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDGG 188
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI------DPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 7506591    189 KPAKIGQLRCSIEII 203
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
438-510 4.17e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 4.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591    438 TLTAKDPDLGQNGWIRYSVLDTE---LVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLL 510
Cdd:pfam00028  17 TVTATDPDLGPNGRIFYSILGGGpggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 39-99 2.18e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 2.18e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591      39 VDISEENIFlKVDERSGEISTIAHLDYEKRSKFDIVaVKVEESGE-----TIDILVEVDDENDNAP 99
Cdd:smart00112  18 LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLT-VEATDGGGpplssTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-97 8.53e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 8.53e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7506591   42 SEENIFlKVDERSGEISTIAHLDYEKRSKFDIVaVKVEESGE-----TIDILVEVDDENDN 97
Cdd:cd11304  40 NEDGLF-SIDPSTGEITTAKPLDREEQSSYTLT-VTATDGGGpplssTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 217-307 1.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  217 YTASVSANISIGSHLITVQATDADIGENSRISYDIkkTSAPSNSNFAI-SQSGVITTTASL--LPASTHDVIVVASDHGS 293
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIdPSTGEITTAKPLdrEEQSSYTLTVTATDGGG 79

                        90
                ....*....|....
gi 7506591  294 PSLSSSAVVTITVL 307
Cdd:cd11304  80 PPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
217-307 8.49e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 8.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591    217 YTASVSANISIGSHLITVQATDADIGENSRISYDIKKTsaPSNSNFAISQ-SGVITTTASL--LPASTHDVIVVASDHGS 293
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPdTGDISTTKPLdrESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 7506591    294 PSLSSSAVVTITVL 307
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 108-208 1.44e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591  108 LEISEFAQLGTSFALPTVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDG 187
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI------DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 7506591  188 GKPAKIGQLRCSIEIIDANDN 208
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 124-210 2.72e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591     124 TVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDGGKPAKIGQLRCSIEII 203
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI------DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 7506591     204 DANDNAP 210
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 438-511 3.81e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 3.81e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7506591  438 TLTAKDPDLGQNGWIRYSVL---DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLLD 511
Cdd:cd11304  18 TVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 235-307 6.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 6.27e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591     235 QATDADIGENSRISYDIkkTSAPSNSNFAI-SQSGVITTTASLL--PASTHDVIVVASDHGSPSLSSSAVVTITVL 307
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIdPETGEITTTKPLDreEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 440-517 7.70e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 7.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591     440 TAKDPDLGQNGWIRYSVL---DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLLDTESKP 516
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 7506591     517 P 517
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
109-203 2.64e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7506591    109 EISEFAQLGTSFALPTVTDGDGPKFDVHRFVILQGNVNNVFKLasrkvnEQLQADLVVNGQLDREFRDKYELLIEAQDGG 188
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI------DPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 7506591    189 KPAKIGQLRCSIEII 203
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
438-510 4.17e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 4.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591    438 TLTAKDPDLGQNGWIRYSVLDTE---LVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQVVADLL 510
Cdd:pfam00028  17 TVTATDPDLGPNGRIFYSILGGGpggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 39-99 2.18e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 2.18e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7506591      39 VDISEENIFlKVDERSGEISTIAHLDYEKRSKFDIVaVKVEESGE-----TIDILVEVDDENDNAP 99
Cdd:smart00112  18 LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLT-VEATDGGGpplssTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-97 8.53e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.39  E-value: 8.53e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7506591   42 SEENIFlKVDERSGEISTIAHLDYEKRSKFDIVaVKVEESGE-----TIDILVEVDDENDN 97
Cdd:cd11304  40 NEDGLF-SIDPSTGEITTAKPLDREEQSSYTLT-VTATDGGGpplssTATVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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