|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
28-408 |
3.69e-88 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 272.56 E-value: 3.69e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYT 107
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVT 187
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 188 GIAYFLFGLWLLATLERKGRFQQPDRslLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSgIADAAQ 267
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAE--KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI-LGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 268 LVAGLVLVNTMTIILFQFPTLKLLENvplFTRTRLGMALMGMAQIGFMFTPEA-FPLGWYLACFVLSMGEVIAFPTLNVQ 346
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVER---FRLRKILMIGILLFAIGFAVLAFAnTLAVLILAMIVLTLGEMLVFPAVQTL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1472939696 347 IDRLAPAHLRGSYFGAAAL-YSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLAQ 408
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALaWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-374 |
2.86e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 130.62 E-value: 2.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 31 VLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIG 110
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 111 LSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 190 AYFLFGLWLLATLERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIadAAQLV 269
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL--SALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 270 AGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQID 348
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWlLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 1472939696 349 RLAPAHLRGSYFGAAAL-YSLGFAIAP 374
Cdd:pfam07690 318 DLAPKEERGTASGLYNTaGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-406 |
3.41e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 3.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 31 VLVGTLFARTSFFMAWPFLIVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIG 110
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 111 LSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE-RGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 190 AYFLFGLWLLATLERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLV 269
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 270 AgLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDR 349
Cdd:cd17325 239 L-LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL--LLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1472939696 350 LAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYL 406
Cdd:cd17325 316 IVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-373 |
2.92e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.22 E-value: 2.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 26 FPVWTVLVGTLFARTSFFMAWPFLIVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFA 105
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLF 184
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER-RGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 185 IVTGIAYFLFGLWLLATLERKGRFQQpdrsllPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIAD 264
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAAR------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 265 AAQlVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEafPLGWYLACFVLSMGEVIAFPTLN 344
Cdd:COG2814 242 ASA-AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQ 318
|
330 340 350
....*....|....*....|....*....|
gi 1472939696 345 VQIDRLAPAHLRGSYFGAA-ALYSLGFAIA 373
Cdd:COG2814 319 ALVAELAPPEARGRASGLYnSAFFLGGPLA 348
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-406 |
1.57e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 101.11 E-value: 1.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 53 LYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMI 132
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 133 EAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAyFLFGLWLLATLERKGRfqQPD 212
Cdd:cd17474 105 GPLALTLIGD-LFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAAL-IPVAFLAILFLLPEPK--EKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 213 RSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLvaGLVL-VNTMTIILFQFPTLKLL 291
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII--GLLFaGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 292 EN-VPLFTRTRLGMALMGMAQIGFMFTPEafpLGWYL-ACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSL 368
Cdd:cd17474 259 KKrFGARRILVIGLLLYALSLLLLGFVPS---LALLLiAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 1472939696 369 GFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYL 406
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-382 |
3.01e-23 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 101.13 E-value: 3.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 33 VGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKW-----------VMVSGALI 101
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 102 ATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP- 180
Cdd:COG2211 97 LLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 181 ------QVLFIVTGIAYFLFGLWLLATLERKGRFQQPdrslLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLP 254
Cdd:COG2211 177 daalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEE----KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 255 QVIVRSgIADAAQLVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGWYLACFVLSM 334
Cdd:COG2211 253 YYFKYV-LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1472939696 335 GEVIAFPTLNVQIDRLAPAHL-------RGSYFGAAAL-YSLGFAIAPLAGGMMIE 382
Cdd:COG2211 332 GLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFaIKLGQALAGALAGLLLA 387
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-405 |
4.87e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 4.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 32 LVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGL 111
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 112 SNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAY 191
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIAD-LFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 192 FLFGLWLLATL-----ERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGiADAA 266
Cdd:cd06174 160 ALALLAAILLLlvvpdPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG-GLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 267 QLVAGLVLVNTMTIILFQFPTLKLLENvpLFTRTRLGMALMGMAQIGFMFTPEAFPLGWYLAC-FVLSMGEVIAFPTLNV 345
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLlLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 346 QIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMI-ENLNAQWLYGLCFVLCLAMMGLYY 405
Cdd:cd06174 317 LIAELFPPEIRGTAFGlLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
29-407 |
9.71e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 90.37 E-value: 9.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 29 WTVLVGTLFARTSFFMAWPFLIVFLYQDYHAtATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMV-----SGALIAT 103
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGS-ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIladllRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEK-DRELALNVryFLLNLGGAIGPLI-GITLALAHPQ 181
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQlVRANALNS--LATQLARIIGPALgGLLVALLGPG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 182 VLFIVTGIAYFLFGLWLLA-TLERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRS 260
Cdd:cd06173 159 GAFAINALSFLLSALLLLFiRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 261 GIADAAQLV-------AGLVLVNTMTIilfqfptlKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLgwYLACFVLS 333
Cdd:cd06173 239 LGGGAAGYGlllaafgVGALLGALLLG--------RLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL--LAALFLLG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1472939696 334 MGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLA 407
Cdd:cd06173 309 LAGGLFNVPLNTLLQLRVPDELRGRVFSVyNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-408 |
1.14e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.88 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 31 VLVGTLFARTSFFMAWPFLIVFLyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIG 110
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 111 LSNQIWQFFIMIVLTGLMRPMIeAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFIVTGI 189
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAF-TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 190 ayFLFGLWLLATLeRKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLanFLMMFVYGQVESSLPQVIVRSGIADaaqlv 269
Cdd:cd17489 159 --LALLALLLVFL-VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL--FLASIAYGAISTFLPLYAAERGISN----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 270 AGLVL-VNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPeaFPLGWYLACFVLSMGEVIAFPTLNVQID 348
Cdd:cd17489 229 AGLFFtVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG--SPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1472939696 349 RLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLAQ 408
Cdd:cd17489 307 DLVPPHRRGAANGTfFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-406 |
2.87e-18 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 85.32 E-value: 2.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLiVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYT 107
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFY-VREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 108 GIGLSNQIWQFFIMIVLTGLMRPMIeAPGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVT 187
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIAD-ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 188 GIAYFLFGLwLLATLerkgrfqqpdrsLLPNFSVtlrviskdsvfvkMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQ 267
Cdd:cd17330 158 AAALALLNL-VLVLF------------FLPPLRR-------------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 268 LVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGmaqIGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQ 346
Cdd:cd17330 212 IGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAI---IGLLLLPFASSVPLlVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1472939696 347 IDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYL 406
Cdd:cd17330 289 LSKSVPSKEQGKAQGiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
47-390 |
6.10e-18 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 85.18 E-value: 6.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 47 PFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:PRK10054 28 PFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALIN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 127 LMRPMIEAPGKAVIGDNL-PDEKDRELALNvrYFLLNLGGAIGPLIGITLALAHPQVLF----IVTGIAYFLFGLWLlat 201
Cdd:PRK10054 108 CAYSVFSTVLKAWFADNLsSTSKTKIFSLN--YTMLNIGWTVGPPLGTLLVMQSINLPFwlaaICSAFPLVFIQIWV--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 202 lERKGRFQQPDRSLLPNFSVTLRviskDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLVAGLVL-VNTMTI 280
Cdd:PRK10054 183 -QRSEKAIATETGSVWSPSVLLQ----DKALLWFTCSGFLASFVSGAFASCISQYVMVVADSDFAEKVVAVVLpVNAAMV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 281 ILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFpLGWYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYF 360
Cdd:PRK10054 258 VSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSGNSL-LLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYF 336
|
330 340 350
....*....|....*....|....*....|
gi 1472939696 361 GAAALYSLGFAIAPLAGGMMIENLNAQWLY 390
Cdd:PRK10054 337 SAQSLGWLGAAINPLVSGVILTTLPPWSLF 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-412 |
7.92e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.55 E-value: 7.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 29 WTVLVGTLFARTSFFMAW---PFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFA 105
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWylwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH-PQVLF 184
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 185 IVTGIAYFLFGLWLLATLERKGRFQQPDRSLLPNfsvTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRS---G 261
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfglS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 262 IADAAQLVAGLVLVNTMTIILFQFptlkLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGwYLACFVLSMGEVIAFP 341
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGW----LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF-LVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1472939696 342 TLNVQIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIENLN----AQWLYGLCFVLCLAMMGLYYLAQREQE 412
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGlVGAAGGLGGFLGPLLFGALLDATGsytaAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-412 |
1.12e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.07 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 20 RVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGA 99
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 100 LIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLALAH 179
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP-PKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 180 P-QVLFIVTGIAYFLFGLWllatlerkgrfqqpdrsllpnfsvtlrviskdsVFVKMMLANFLMMFVYGQVESSLPQVIV 258
Cdd:COG2271 162 GwRAAFLILGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 259 RS---GIADAAQLVAGLVLVNTMTIILFQFPTLKllenvpLFTRTRLGMALMGMAQIGFMFTPEAFPLGW--YLACFVLS 333
Cdd:COG2271 209 EVrglSLAQAGLLLSLPFLAGIVGSLLGGWLSDR------LGRRRKLVLAIGLLLAALALLLLALLPSPAlaIALLFLAG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 334 MGEVIAFPTLNVQIDRLAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLAQREQE 412
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVnTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-199 |
1.85e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.31 E-value: 1.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 3 KSEQKATEGSESLFQWERVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYS 82
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 83 GYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLN 162
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG-RGTAMGLFNTAFS 334
|
170 180 190
....*....|....*....|....*....|....*...
gi 1472939696 163 LGGAIGPLI-GITLALAHPQVLFIVTGIAYFLFGLWLL 199
Cdd:cd17325 335 LGMVLGPLLgGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-409 |
3.63e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 3.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 25 NFPVWTVLVGTLFARTSFFMA-WPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIAT 103
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATAlWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRelALNVRYFLLNLGGAIGPLIGITLALAHP--- 180
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS--RLNLLHAFFSLGALLGPLLGGLLILLGLsls 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 181 -QVLFIVTGIAYFLFGLWLLATlerKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVR 259
Cdd:COG0738 163 wHLPYLILAVLLLLLALLFLRS---KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 260 SGIADAAQlvAGLVLVNTM-TIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGWylACFVLSMGEVI 338
Cdd:COG0738 240 VLGLSEAT--AALGLSLFWgGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALI--GLALVGLGLSL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1472939696 339 AFPTLNVQIDRLAPAH--LRGSYFGAAAlySLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLAQR 409
Cdd:COG0738 316 MFPTIFSLALDGLGKRtaAAVSAVLIMG--IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
2-199 |
1.31e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 71.81 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 2 AKSEQKATEGSESLFQWERVKRFNFPVWTVLVGTLFARTSFFmAWPFLIvFLYQDYHATATEVGAMLATSALVGSLTGLY 81
Cdd:cd17370 176 VVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNF-SFAFLI-LRAQELGLSAALIPLLYALFNLVYALAAYP 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 82 SGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLL 161
Cdd:cd17370 254 AGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL-RGTAYGLFNTVV 332
|
170 180 190
....*....|....*....|....*....|....*....
gi 1472939696 162 NLGGAIGPLI-GITLALAHPQVLFIVTGIAYFLFGLWLL 199
Cdd:cd17370 333 GIGWLLASLIaGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-408 |
2.34e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 2.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 59 ATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKA 138
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 139 VIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAYFLFGLWLLATLERKGRFQQPDRSLlpn 218
Cdd:cd17473 112 LIGD-YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPG--- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 219 fSVTLRVISKDSVFVKMMLANFLMMFVYGQVeSSLPQVIVRSGIADAAQlvAGLVL-VNTMTIIL--FQFPTLKLLENVP 295
Cdd:cd17473 188 -AATAAALPWKRVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGGGSAAL--IGLALaIASLAGAIgaLLFGRLKRRLGKR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 296 LFtrTRLGMALMGMAQIGFMFTPeaFPLGWYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAP 374
Cdd:cd17473 264 RL--LAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIvTSAFFLGQFLSP 339
|
330 340 350
....*....|....*....|....*....|....*
gi 1472939696 375 LAGGMMIENL-NAQWLYGLCFVLCLAMMGLYYLAQ 408
Cdd:cd17473 340 LVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-201 |
6.42e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.42 E-value: 6.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 25 NFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATF 104
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVryFLLNLGGAIGPLIGiTLALAHPQVLF 184
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL--AAYNLGGALGAALG-GLVLDHGGWAG 353
|
170
....*....|....*..
gi 1472939696 185 IVTGIAYFLFGLWLLAT 201
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-409 |
1.99e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTS---FFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIAT 103
Cdd:COG2807 15 GRWLLLLAIVLVALNlrpAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEkdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQ 181
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALAAGLTVPLAAALgwRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 182 VLFIVTGIAYFLFGLWLLATLERKGRFQQPDRsllpnfSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSG 261
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPA------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 262 I--ADAAQLVAGLVLVNtmtiILFQFPTLKLLENVPLFTRTRLGMALMGMAQI-GFMFTPEAFPLGWylaCFVLSMGEVI 338
Cdd:COG2807 247 LsaATAGLLLSLFQLAG----IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLlGLLLAPGSLPWLW---AVLLGLGQGG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1472939696 339 AFPT-LNVQIDRLAPAHLRGSYFGAA-ALYSLGFAIAPLAGGMMIENL-NAQWLYGLCFVLCLAMMGLYYLAQR 409
Cdd:COG2807 320 LFPLaLTLIGLRARTPAEAAALSGMAqSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-207 |
2.51e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.51 E-value: 2.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 26 FPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGR--KWVMVSGALIAT 103
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 104 FAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGP-LIGITLALAHPQV 182
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPlLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....*
gi 1472939696 183 LFIVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
28-403 |
8.16e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 63.33 E-value: 8.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLIVFLYQdYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMV-SGALIATFAY 106
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLViLGYGLSALAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 107 TGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIG---ITLALAHPQVL 183
Cdd:cd17370 80 PLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSG-RGKAFGLHRALDTLGAVLGPLLAallLYLLGGNYRTI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 184 FIVTGIAYFLFGLWLLATLERKGRfqqPDRSLLPNFSVTLRVISKDsvFVKMMLANFLMMFVYgqveSSLPQVIVRSGIA 263
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPR---PPKLRKKSKKTSLKKLPKA--FWLYLLAVALFALGN----FSFAFLILRAQEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 264 DAAQLVAGLVLVNTMTI-ILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEafPLGWYLACFVLSMGEVIAFPT 342
Cdd:cd17370 230 GLSAALIPLLYALFNLVyALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS--LWLLLLGFILWGLYMGAQESI 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 343 LNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGL 403
Cdd:cd17370 308 ERAAVADLVPAELRGTAYGLfNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-245 |
1.77e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 32 LVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGL 111
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 112 SNQIWQFFIMIVLTGLM-RPMIEAPGKAVIGdnLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGI 189
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGyGSVQPGGGRAIMR--WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGwRAAFVVAGL 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1472939696 190 AYFLFGLWLLATLeRKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFV 245
Cdd:cd17475 159 VSILAAVLFWLFY-REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAP 213
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
53-247 |
2.94e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.48 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 53 LYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMI 132
Cdd:cd17328 25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 133 EAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHP--QVLFIVTGIAYFLFGLWLLATLE--RKGRF 208
Cdd:cd17328 105 SPIAPTIIADLFPKEK-RTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwRWAFRVTGVLGVLLAILLLLFVRepPRGAA 183
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1472939696 209 QQPDR--SLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYG 247
Cdd:cd17328 184 EGGVMakSTATSFLADLKALAKNPSFILSTLGFTAVSFVTG 224
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-199 |
3.74e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.09 E-value: 3.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 2 AKSEQKATEGSESLFQWERVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLY 81
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 82 SGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLL 161
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL-RGRVFSVYNALN 342
|
170 180 190
....*....|....*....|....*....|....*....
gi 1472939696 162 NLGGAIGPLIGITLALAH-PQVLFIVTGIAYFLFGLWLL 199
Cdd:cd06173 343 SGAMPLGALLAGLLADALgLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-401 |
9.64e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.87 E-value: 9.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPfLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYT 107
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQG-LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIG-PLIGITLALAHPQVLFIV 186
Cdd:cd17324 80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK-RGRAIGLVFSGLTLGLVLGrPLGGLLGQLLGWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 187 TGIAYFLFGLWLLATLERKGRFQQPDRSLLPNFSVTLRviskDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAA 266
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLR----NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 267 QLVAGLVLV---NTMTIILFQfptlKLLENVPlFTRTRLGMALMGMAQIGFMFTPEAfPLGWYLACFVLSMGEVIAFPTL 343
Cdd:cd17324 235 AIIGLLLLFgvaGVVGSPLAG----RLADRGG-RRALLIALLLLAAALLLLTLLGPS-PLLLLVGLVLWGLGFFAAHSAL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1472939696 344 NVQIDRLAPAHL-RGSYFGAAALYsLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMM 401
Cdd:cd17324 309 QTRVLRLAPEARgLASSLYLAAYN-LGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
27-403 |
1.08e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 59.98 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSF-FMAWP-FLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATF 104
Cdd:cd17355 1 GWVVLAVTFLILILSWgIRYYFgVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 105 AYTGIGLSNQIWQFFI-MIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNvryfLLNLGGAIGPLIGITLALAHPQVL 183
Cdd:cd17355 81 GLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERR-RGLALG----ILTAGGGLGSLVFLPLGAALIEAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 184 -----FIVTGIAYFL--FGLWLLATLERKGRFQQPDR-SLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQ 255
Cdd:cd17355 156 gwrtaLLVLALLALLvlVPVLLLLRRRPADLALRAYDdASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 256 VIVRSGI--ADAAQLVAGLVLVNTMTIILFQFptlkLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGW-YLACFVL 332
Cdd:cd17355 236 YLADRGIspAAAAVALALIGLFNIVGRLLSGW----LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLlFAALFGL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 333 SMGEVIAFPTLNVQidRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIENLNAqwlYGLCFVLCLAMMGL 403
Cdd:cd17355 312 GWGATVPLTAALAA--RYFGARSYGTLFGlVFAPHQLGSALGPWLGGLLYDRTGS---YTAAWALAVALGLI 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
31-403 |
3.60e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.95 E-value: 3.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 31 VLVGTLFARTSFFMAWPFLIVFLYQdYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIG 110
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 111 LSNQIWQFFIMIVLTGLMRPMIeapgkAVIGD----NLPDEKDRELALNVRYFLLNLGGAIGPLIgITLALAHPQVLFIV 186
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGL-----FVVSEswlnALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 187 TGIAYFLFGLWLLATLERKGRFQQPDRSLLpnfsvtlrviskdSVFVKMMLANFLMMFVYGQVESS----LPQVIVRSGI 262
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEEAESISL-------------RRLLRIAPLALLGAFVAGFLEGAfyslLPLYGLRLGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 263 --ADAAQLVAGLVLVNtmtiILFQFPTLKLLENVPLFtRTRLGMALMGMAQIGFMFTPEAFPLGWYLACFVLSMGEVIAF 340
Cdd:cd17477 221 svAQAALLLAAFVLGG----LLLQWPLGWLADRFDRR-RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLY 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1472939696 341 PT-LNVQIDRLAPAHLRGSYFGAAALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGL 403
Cdd:cd17477 296 TLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-128 |
3.77e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 3.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 13 ESLFQWERVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRK 92
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRR 260
|
90 100 110
....*....|....*....|....*....|....*.
gi 1472939696 93 WVMVSGALIATFAYTGIGLSNQIWQfFIMIVLTGLM 128
Cdd:cd17478 261 RVIIASLLLAAPFLLLFLLTPGIWS-YILLVLAGFL 295
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
49-406 |
4.40e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.72 E-value: 4.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 49 LIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLM 128
Cdd:cd17333 18 LGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 129 RPMIEAPGKAVIGDNLPdeKDRELALNVRYFLLNLGGAIGPLIG--ITLALAHPQVLFIVTGIAYFLFGL-WLLATLERK 205
Cdd:cd17333 98 AGILDTGANTFVGALFE--ESSATRLNVLHGFFGLGALIGPLIAtsLLTSELSWSWAYLIIGLIYLLLAIlILLTLFPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 206 GRFQQPDRSllpNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESS--LPQVIVRSGiaDAAQLVAGLVLVNTMTII-- 281
Cdd:cd17333 176 PSARNPQQS---VGAFSASASRLLRNPSIILGALALFLYVGAETAFSswVPSYLVEKK--HVSDGLAGYLLSGFWVGIti 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 282 ---LFQFPTLKLLENVPLFTRTRLGMALMgmaqigFMFTPEAFPLGWYLACFVLSMGEVIAFPTLN-VQIDRLAPAHLRG 357
Cdd:cd17333 251 grlLGGPISRRIKPHTLLVLSGSGALLGL------LILLLAPTLVVGLVATALLGLFMAALFPTILsLGISNLPYAKGKG 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1472939696 358 -SYFGAAAlySLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYL 406
Cdd:cd17333 325 tSVLLAAG--SIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-203 |
9.15e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.79 E-value: 9.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 32 LVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGALIATFAYTGIG 110
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 111 LSNQIWQFFIM-IVLTGLMR---PMIEAPGKAVIgdNLPDEKDRELALNVRYFLLNLGGAIGPLIG-ITLALAHPQVLFI 185
Cdd:cd17471 82 FLRNYWVLLLVgVVLLSLGAaafPQLFALAREYA--DRSSGRDATLFNSVLRAAFSLAWVIGPPLAfLLLDVLGFTGLFL 159
|
170
....*....|....*...
gi 1472939696 186 VTGIAYFLFGLWLLATLE 203
Cdd:cd17471 160 LAALLYLVVALLVLFLLP 177
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
31-378 |
2.18e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.73 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 31 VLVGTLFARTSFFMAWPFLIVFLYQDYHATATEV----GAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAY 106
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 107 TGIGLSNQIWQFFIMIVLTGLMRPMIEApGKAVIGDNLPDEKDrELALNVRYFLLNLGGAIGPLIGITLA-LAHPQVLFI 185
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPN-ATALIASQTPKEKS-GWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 186 VTGIayFLFGLWLLATLERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVI-VRSGIAD 264
Cdd:cd17391 159 ITGG--LLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIrQLMGDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 265 AAQLVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGmaqiGFMFTPEAF-----PLGWYLACFVLSMGEVIa 339
Cdd:cd17391 237 NLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLAS----ALLYIPQAFvqtpwQLGILRFLLGLATGGLL- 311
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1472939696 340 fPTLNVQIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGG 378
Cdd:cd17391 312 -PAINSLLAKITPKEVAGRIFGyNQSFQYLGNVAGPLLGS 350
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-409 |
3.54e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 54.90 E-value: 3.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 47 PFLIVFlYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGALIATFAYTGIGLSNQI-WQFFIMIVL 124
Cdd:cd17335 18 PFLSVY-LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIfWLLLLLVIL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 125 TGLM----RPMIEAPGKAVIGDNlpdekdrelalNVRYFLLNLGGAIG-----PLIGITLALAH----PQVLFIVTGIay 191
Cdd:cd17335 97 GAFFsapvVPLVDSITLQYLGEE-----------RERYGKQRLWGSIGfgiaaLLVGILIDRSStyknYTIAFYVFAV-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 192 FLFGLWLLATlerKGRFQQPDRSLLPNFSvTLRVISKDSVFVKMMLANFLMMFVYGQVESSLpqVIVRSGIADAAQLVAG 271
Cdd:cd17335 164 LMLLALLLAL---KFPFRPKHPEPNENTG-GLLALLRNPRVLAFLLVAFLMGFGHGLIYSFL--FWHLQDLGGSKTLIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 272 LVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAfplgWYL--------ACFVLSMGEVIAFptl 343
Cdd:cd17335 238 LWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENP----WLVlpiellhgLTFALVWAAAVSY--- 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1472939696 344 nvqIDRLAPAHLRGSYFG--AAALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLAQR 409
Cdd:cd17335 311 ---ASAAAPPGLRATAQGllQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-226 |
6.46e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.10 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 47 PFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:cd17478 16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 127 LMRPMIEAPGKAVIgdNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHPQVLFIVTGIAYFLFGLWLLATLERKG 206
Cdd:cd17478 96 IGSAAFHPEGARLA--SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180
....*....|....*....|
gi 1472939696 207 RFQQPDRSLLPNFSVTLRVI 226
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGV 193
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
19-200 |
1.66e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 52.91 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 19 ERVKRFNFPVWTVL----------VGTLFARTS-FFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSD 87
Cdd:cd17369 210 EAGQVVRAPLVEVLrrhwralllaIGLRLAENVlFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSD 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 88 KFGRKWVMVSGALI----ATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDekdrelalNVRY----F 159
Cdd:cd17369 290 RVGRRPVYLAGALLaalfAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPT--------RVRYtgasL 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1472939696 160 LLNLGGAIG----PLIGITLALAHpqvlFIVTGIAYFLFGLWLLA 200
Cdd:cd17369 362 GYQLGAILGggfaPLIATALVAAT----GSWWPVALYLAALAVIS 402
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
55-314 |
2.97e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.74 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:COG0477 42 ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 135 PGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATLERKGRFqqpdr 213
Cdd:COG0477 122 GALALIAELFPARE-RGRALGLWGAAIGLGLALGPLLGGLLVAALGwRWIFLINAPLGLLALVLRLRLPESRGLL----- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 214 sLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQLVAGLVLVNTMTIILFQFPTLKLLEN 293
Cdd:COG0477 196 -LALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLAL 274
|
250 260
....*....|....*....|.
gi 1472939696 294 VPLFTRTRLGMALMGMAQIGF 314
Cdd:COG0477 275 LLALLLLLLLLLLLLLLALLL 295
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-196 |
3.97e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.66 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGALIATFA 105
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQVL 183
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI-RGTAFGLLNTFGFLGGAIGPLLAGFLLAATfgLTGA 362
|
170
....*....|...
gi 1472939696 184 FIVTGIAYFLFGL 196
Cdd:cd06174 363 FLVLAVLLLLAAI 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-172 |
4.01e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.81 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSFFMAWpFLIVFLYQD-----YHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALI 101
Cdd:cd17504 178 NVLLANITALLAGFGMFMVF-QLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 102 ATFAYTGIGLSNQ-IWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEkDRELALNVRYFLLNLGGAIGPLIG 172
Cdd:cd17504 257 SAVGLLLLALLHSsLWALVVALLLIGIGLGLAFASLPNIVVESVPPD-RTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-196 |
4.05e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAY 106
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 107 TGIGLS--NQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRE------LALNVRYFLLNLGGAIGPLI-GITLAL 177
Cdd:COG2211 309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALaGLLLAL 388
|
170 180
....*....|....*....|....
gi 1472939696 178 AH-----PQVLFIVTGIAYFLFGL 196
Cdd:COG2211 389 FGyvagaAQSPSALTGIRLLFFLL 412
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-207 |
5.59e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 5.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVM-VSGALIATFAY 106
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLlIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 107 TGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIGITLALA--HPQVLF 184
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP-TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAF 365
|
170 180
....*....|....*....|...
gi 1472939696 185 IVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
27-127 |
2.81e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAY 106
Cdd:cd17471 200 RLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFY 279
|
90 100
....*....|....*....|.
gi 1472939696 107 TGIGLSNQIWQFFIMIVLTGL 127
Cdd:cd17471 280 LGLALATSLWQLIALQLLNAI 300
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
48-202 |
5.91e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 5.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 48 FLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDK-FGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:cd17474 220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1472939696 127 LMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLI-GITLALAHPQVLFIVTGIAyFLFGLWLLATL 202
Cdd:cd17474 300 LGLGLNLPLLTTLVTELAPEEE-RGTASSLYNFVRFLGQAVGPLLfGLLLEIFGLSAPFLVGAAI-ALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-200 |
8.78e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 25 NFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATF 104
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAH--PQV 182
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPEL-RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTggLSG 354
|
170
....*....|....*...
gi 1472939696 183 LFIVTGIAYFLFGLWLLA 200
Cdd:cd17473 355 AFLILGVLALVLAIVLLL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-169 |
1.03e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 2 AKSEQKATEGSESLFQWERVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLY 81
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 82 SGYLSDKFGRK---WVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRY 158
Cdd:pfam07690 255 LGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE-RGTASGLYN 333
|
170
....*....|.
gi 1472939696 159 FLLNLGGAIGP 169
Cdd:pfam07690 334 TAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
231-422 |
1.18e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.89 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 231 VFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAqlVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMA 310
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ--AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 311 QIGFMFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMMIENLNAQWL 389
Cdd:COG2814 89 SLLCALAPSLWLL--LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLlGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190
....*....|....*....|....*....|...
gi 1472939696 390 YGLCFVLCLAMMGLYYLAQREQEMGEKERLSRA 422
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
48-342 |
1.51e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.83 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 48 FLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG------RKWVMVSG---ALIATFAYTGIGLSN--QIW 116
Cdd:cd17332 21 YLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgrfRPWLLWGAiplALLFVLLFTTPDGSGtgKLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 117 QFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIG----PLIGITLALAHPQVLFIVTGIAY- 191
Cdd:cd17332 101 YALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVtvlpPPLVAYFGGGNASRGYFLTALIIg 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 192 --FLFGLWLLATLERKGRFQQPDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAA-QL 268
Cdd:cd17332 181 iiGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAElVL 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1472939696 269 VAGLVLVNTMTIILFQFPTLKLLENVPLFtrtRLGMALMGMAQIGFMFTPEAFPLGWYLACFVLSMGEVIAFPT 342
Cdd:cd17332 261 LLLLILSGALLALLPWPPLKKRFGKKKAF---FIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLL 331
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-202 |
1.97e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 29 WTVLVGTLFARTSFFM---AWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFA 105
Cdd:cd17312 2 WRIFLGVFLGYAAYYVcrkNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGdNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLF 184
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLG-NWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGwRAAF 160
|
170
....*....|....*...
gi 1472939696 185 IVTGIAYFLFGLWLLATL 202
Cdd:cd17312 161 LVPGIVGLVVAIILFFFL 178
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-207 |
2.37e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 46.30 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYT 107
Cdd:COG2270 240 LLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRElalnvrYF-LLNLGG----AIGP-LIGITLALAHPQ 181
Cdd:COG2270 320 AAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAE------FFgLYALSGkaasFLGPlLFGLVTQLTGSQ 393
|
170 180
....*....|....*....|....*.
gi 1472939696 182 VLFIVTGIAYFLFGLWLLATLERKGR 207
Cdd:COG2270 394 RLGILSLIVFFVIGLVLLLRVKVPRG 419
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
52-412 |
2.75e-05 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 46.28 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 52 FLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSG----ALIATFA--YTGIGLSNqIWQFFIMIVLT 125
Cdd:pfam05977 35 WLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGqlllALVSTLLtlLAGLGLLS-PWLLLGLTFLG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 126 GLMRPMIEAPGKAVIGDNLP-DEKDRELALNVRYFllNLGGAIGPLI-GITLALAHPQVLFIVTGIAYFlFGLWLLATLE 203
Cdd:pfam05977 114 GIGTALMDPAWQASVPELVPrRDLPAAVALNSVGY--NIARSVGPALgGVLLAAFGPAFTFALNALSYF-AVIAALWRWK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 204 RKGRFQQ-PDRSLLPNFSVTLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVivrsgiadAAQLVAGLVLVntMTIIL 282
Cdd:pfam05977 191 RAAPASPlPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLV--------ARDLLDGDAIF--YGILL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 283 FQFPTLKLLENVPL-FTRTRLGM-ALMGMAQIGFMFTPEAFPL--GWYLACFVLSMGE---VIAFPTLNVQIDRLAPAHL 355
Cdd:pfam05977 261 GAVGVGAILGALSLpRLRERLGSdRLVLLASVVTALVLLSLALapNLWLAIPVLLLGGaawITALTTLNVAVQLSVPRWV 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 356 RGSyfgAAALYSLGFAIAPLAG----GMMIENLNAQW-LYGLCFVLCLAMMGLYYLAQREQE 412
Cdd:pfam05977 341 RGR---ALAVYQTVFFGGMAAGswlwGAVAEALSVTGaLLGAAAALLAGAAAGLRFRLPEGE 399
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
67-210 |
2.92e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 67 MLATSALVGSLTG-LYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLP 145
Cdd:TIGR00895 56 FLFSAGLIGMAFGaLFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAP 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1472939696 146 DeKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATLERKGRFQQ 210
Cdd:TIGR00895 136 K-RFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGwRSLFYVGGIAPLLLLLLLMRFLPESIDFLV 200
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-196 |
4.02e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 28 VWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIA---TF 104
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgilAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 105 AYTGIGLSNQIWQFFIMIVLTGLMRPMieAPGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGP-LIGITLALAHPQVL 183
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGV--WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPpLIALLLASTGGTGV 336
|
170
....*....|...
gi 1472939696 184 FIVTGIAYFLFGL 196
Cdd:cd17316 337 PALILALLAIVAL 349
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-172 |
4.06e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.64 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17323 27 EDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLA 106
|
90 100 110
....*....|....*....|....*....|....*...
gi 1472939696 135 PGKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIG 172
Cdd:cd17323 107 IGAGTIAD-LFTPEERGKAMGVYSLGPLLGPALGPIIG 143
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
29-407 |
4.52e-05 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 45.44 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 29 WTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTG 108
Cdd:PRK11646 13 YFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFAT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 109 IGLSNQIWQFFIMIVLTGLMRPMIEAPGKA-VIGDNLPDEKDRelalnvRYFLLNLGGAIGPLIGITLA---LAHPQVLF 184
Cdd:PRK11646 93 MAIAHEPWLLWLSCILSGLGGTLFDPPRTAlVIKLIRPHQRGR------FFSLLMMQDSAGAVIGALLGswlLQYDFRLV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 185 IVTGIAYF----LFGLWLLATLerkgRFQQPDRSLLPNFSVTLRviskDSVFVK--MMLANFLMMFVygQVESSLPqvIV 258
Cdd:PRK11646 167 CATGAVLFvlaaAFNAWLLPAY----KLSTVRTPVREGMTRVLR----DKRFVTyvLTLTGYYMLAV--QVMLMLP--IM 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 259 RSGIADAAQLVAGLVLVNTMTIILFQFPTLKLLEN-VPLFTRTRLGMALM--GMAQIGFMFT-PEAFPLgwyLACFVLsm 334
Cdd:PRK11646 235 VNDIAGSPSAVKWMYAIEACLSLTLLYPIARWSEKrFRLEHRLMAGLLIMslSMFPIGMVSNlQQLFTL---ICLFYI-- 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1472939696 335 GEVIAFPTLNVQIDRLAPAHLRGSYFGAAAL-YSLGFAIAPLAGGMMIENLNAQWLYGLCFVLcLAMMGLYYLA 407
Cdd:PRK11646 310 GSIIAEPARETLSASLADARARGSYMGFSRLgLALGGAIGYIGGGWLFDLGKALNQPELPWMM-LGIIGLITLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-193 |
4.66e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 21 VKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLT-GLYSGYLSDKFGRKWVMVSGA 99
Cdd:cd17330 169 VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 100 LIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDeKDRELALNVRYFLLNLGGAIGPLI-GITLALA 178
Cdd:cd17330 249 LLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS-KEQGKAQGIIQSLQSLARIIGPLLaGPLYSFL 327
|
170
....*....|....*
gi 1472939696 179 HPQVLFIVTGIAYFL 193
Cdd:cd17330 328 GPGVPFLLAAGLLLI 342
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
55-373 |
7.07e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 7.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17321 24 RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 135 PGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLI-GITLALAHPQVLFIVTGIayflFGLWLLAtlerkgrfqqpdr 213
Cdd:cd17321 104 ASLALIAATFPGER-RGRALGLWGAVVGIGAALGPLLgGLLLELFGWRWIFLINVP----IGLVALL------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 214 sLLPNFSVTlrviskdsvfvkmMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlvAGLVLVnTMTIILFQFPTL--KLL 291
Cdd:cd17321 166 -LARTFSGA-------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ--AGLALL-PLALAMLVAAPLagRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 292 ENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLG-WYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSyfgAAALYS--- 367
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWlLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA---ASGILNtar 305
|
....*..
gi 1472939696 368 -LGFAIA 373
Cdd:cd17321 306 qLGGALG 312
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
43-402 |
9.04e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.51 E-value: 9.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 43 FMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17472 13 FLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 123 VLTGLmrPMIEAPGKAVIGDNLPDEK-DRELAL--NVRYFLLNLGGAIGPLIGITLALahpQVLFIVT---GIAYFLFGL 196
Cdd:cd17472 93 ALQGS--GAISSVVMALLADLTREENrTKAMALigASIGIAFAISMVLGPLLAAHLGV---SGLFLITailSLVSLLILL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 197 WLLATLERKGRFQQPDRSLLPNfsvtlrvISKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlvaGLVLVN 276
Cdd:cd17472 168 FFVPDPPKIVQISEKEKKKLKK-------LLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL---WKVYLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 277 TMTIILF-QFPTLKLLENV----PLFtrtRLGMALMGMAQIGFMFTPEAFPLgwylacfvLSMGEVIAF-------PTLN 344
Cdd:cd17472 238 AILIGFIlMVPFVIYAEKKgkmkQVF---VSSILLIAVGFLLLLFAATSLWL--------LIIGLIIFFigfnlleALLP 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 345 VQIDRLAPAHLRGSyfgAAALYS----LGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMG 402
Cdd:cd17472 307 SLVSKIAPKEYRGT---AMGIYNtsqfLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
29-378 |
1.41e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 43.72 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 29 WTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGS--LTGLYSGYLSDKF-GRKWVMVSGALIATFA 105
Cdd:cd17346 5 YTLFFTEMWERFSYYGMRAILILYLTAQLGDGFSEADAASIYGAYTALvyLTPIIGGWLADKVlGARRTVFIGGILMALG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQI-WQFFIMIVL----TGLMRPMIEApgkaVIGDNLP-DEKDRELALNVRYFLLNLGGAIGPLIGITLALAH 179
Cdd:cd17346 85 YLLLALSPFSvSMLYLGLALiivgNGLFKPNISS----LVGKLYDeNDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 180 P-QVLFIVTGIAyFLFGLWLLATLERKgrfqqpdrsllpnfsvtLRVISKDSVFVKMMLANFLMMFVYGQVESSLPQVI- 257
Cdd:cd17346 161 GyHYGFGLAAVG-MLLGLLIFLLGRKK-----------------LLERKKMLAIIILFLFAVVFWAIYEQAGTSLALFAd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 258 --VRSGIADAAQLVAGLVLVNTMTIILFQFPTLKL---LEN----VPLFTRTRLGMALMGMA----QIGFMFTPEAFPLG 324
Cdd:cd17346 223 enVDRLLGGFTIPPSWFQSLNPLFIILLAPILAALwtkLGKrgkdPSIPTKFALGLLLLGLSfllmVLAASFAGGSGKVS 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1472939696 325 WY---LACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGaaaLYSLGFAIAPLAGG 378
Cdd:cd17346 303 ALwlvLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMG---LWFLASALGNILAG 356
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-407 |
1.52e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.72 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 55 QDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEA 134
Cdd:cd17320 27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 135 PGKAVIGDNLPDEKdrelaLNVRYFLLNLGGAIGPLI-----GITLALAHPQ----VLFIVTGIAYFLFGLWLLATLERK 205
Cdd:cd17320 107 VARAIVRDLYSGAE-----LAKIFSLLMMILAIAPALapllgGLLLLFFGWRaifvFLALLGLLLLLLVLLFLPETLPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 206 GRfqqpdRSLLPNFSVTLRVISKDSVFVKMML---ANFLMMFVYgqvESSLPQVIVRSGIADAAQlVAGLVLVNTMTIIL 282
Cdd:cd17320 182 KR-----KPLLSSLLRAYKRVLKNRRFLGYALalgLSFAGLFAY---LAAAPFIYIEQLGLSPAQ-FGLLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 283 FQFPTLKLLENVPLFTRTRLGMALMGMAQIGFMFT-----PEAFPLGWYLACFVLSMGevIAFPTLNVQIDRLAPaHLRG 357
Cdd:cd17320 253 GSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGFG--LIFPNATSLALEPFP-HVAG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1472939696 358 SyfGAAALYSLGFAIAPLAGGMMIENLNAQWL--YGLCFVLCLAMMGLYYLA 407
Cdd:cd17320 330 T--ASALLGFLQFLIGALAGALVGLLPNGTALpmGLLILVLGLLALLLLILL 379
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
47-375 |
2.34e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.01 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 47 PFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTG 126
Cdd:cd17388 23 PTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 127 LMRPMIeAPGKAVIGDNLPDEKdrelalNVRYFLLnLGGA------IGPLIGITLALAHPQVLFIV----TGIAYFLFGL 196
Cdd:cd17388 103 ITGATG-AVAAAYIADVTPPEQ------RARNFGL-LGAAfglgfiAGPALGGLLGEISPRAPFLVaaglNGLNFLLGLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 197 WLLATLERKGRFQQPDRSLLPnfSVTLRVISKDSVFVKMMLANFLMMFVyGQVESSLPQVIVRSGIADAAQLVAGLVLVN 276
Cdd:cd17388 175 VLPESLPPERRRAFRWRRANP--FGSLRWLTGFPGLLGLLAVFFLIQLI-GQVPATTWVLFTEDRFDWSPTMVGLSLAVF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 277 TMTIILFQ-FPTLKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFplgWYLACFVLSMGEVIAFPTLNVQIDRLAPAHL 355
Cdd:cd17388 252 GLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGW---MVFPILILLALGGIAGPALQGLLSRQVPENE 328
|
330 340
....*....|....*....|.
gi 1472939696 356 RGSYFGA-AALYSLGFAIAPL 375
Cdd:cd17388 329 QGELQGVlTSLTSLTSIIGPL 349
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
52-127 |
2.51e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.94 E-value: 2.51e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1472939696 52 FLYQDYHATATEVGaMLATSALVGSLTG-LYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGL 127
Cdd:cd17359 26 FLQTDFNLTPFLEG-LVVSSALLGAAIGaLFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGL 101
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
63-199 |
3.20e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.60 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 63 EVGAMLATSALVGSLTG---LYS----GYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIeAP 135
Cdd:cd17390 25 SLGASPTVIGLIGSVYGalqLFSsplvGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQ-SL 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1472939696 136 GKAVIGDnLPDEKDRELALNVRYFLLNLGGAIGPLIGITL----------ALAHPQVLFIVTGIAYFLFG-LWLL 199
Cdd:cd17390 104 CKAYLSD-LVSEQERSRVLGRFNAASSLGFILGPVVGGHLaetdggfyyvALLCSAIFILNAGLVWFLLSkLWDL 177
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-202 |
3.42e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.75 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 37 FARTSFFMAWPFLIvflyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIW 116
Cdd:TIGR00881 9 LVRKNFALAMPYLV----EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 117 QFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAIGPLIgITLALAHP---QVLFIVTGIAYFL 193
Cdd:TIGR00881 85 VMAALWALNGIFQGMGWPPCGRTVTKWFS-RSERGTWVSFWNCSHNVGGGLLPPL-VLFGIAELyswHWVFIVPGIIAII 162
|
....*....
gi 1472939696 194 FGLWLLATL 202
Cdd:TIGR00881 163 VSLICFLLL 171
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
33-204 |
4.02e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 42.60 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 33 VGTLFARTSFFMAWPFLIVFLYQdyhATATEVGAMLATSALVGSLTGLYS-------GYLSDKFGRKWVMVSGALIATFA 105
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQ---LGVTGHSALNMWSGLVFSITFLFSaiaspfwGGLADRKGRKIMLLRSALGMGIV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 106 YTGIGLSNQIWQFFIMIVLTGLMRPMIEApGKAVIGDNLPDEKDrELALNVRYFLLNLGGAIGPLIGITLALAH--PQVL 183
Cdd:PRK09874 98 MVLMGLAQNIWQFLILRALLGLLGGFVPN-ANALIATQVPRNKS-GWALGTLSTGGVSGALLGPLAGGLLADSYglRPVF 175
|
170 180
....*....|....*....|.
gi 1472939696 184 FIVTGIAYFLFGLWLLATLER 204
Cdd:PRK09874 176 FITASVLFLCFLVTLFCIREN 196
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
44-195 |
4.03e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 44 MAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGALIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 123 VLTGLMRPMIeAPGKAVIGDNLPDEKDReLALNVRYFLLNLGGAIGPLI---------------GITLALAHPQVLFIVT 187
Cdd:cd17341 96 FLLGFAGANF-ASGQPWASFWFPKEKIG-GAAGGIAGAGNMGVAVSQLLapliagaivfdggfvGWRNAFFVPGILLAIA 173
|
....*...
gi 1472939696 188 GIAYFLFG 195
Cdd:cd17341 174 AVLVLLFG 181
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
18-128 |
4.33e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 18 WERVKRFNFPVWTVLVGTLFARTSFFMAWPFLIVFL-----------YQDYHATATEVGAMLATSALVGSLTGLYSGYLS 86
Cdd:cd17313 226 LKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMgeevyhgtsaaSSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLG 305
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1472939696 87 DKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLM 128
Cdd:cd17313 306 KKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIG 347
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
47-127 |
4.55e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.21 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 47 PFLIVFlyqdyHATATEVGAMLATSALVGSLTGLYSGYLSDKFG-RKWVMVSGALIATFAYTGIG------LSNQIWQFF 119
Cdd:cd17385 226 PHLRQF-----KLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVI 300
|
....*...
gi 1472939696 120 IMIVLTGL 127
Cdd:cd17385 301 IGLVLLGL 308
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
83-207 |
7.84e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 41.35 E-value: 7.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 83 GYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKDRELALNVRYFLLn 162
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVL- 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1472939696 163 LGGAIGPLIGITL-ALAHPQVLFIVTG----IAYFLFGLWLLATLERKGR 207
Cdd:PRK15403 151 VAPIIGPLSGAALmHFVHWKVLFAIIAvmglIAFVGLLLAMPETVKRGAV 200
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
68-202 |
8.38e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.42 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 68 LATSALVGSLTG-LYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPd 146
Cdd:cd17365 39 VGSAALFGMAIGaLLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAP- 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1472939696 147 EKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATL 202
Cdd:cd17365 118 ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGwRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
235-417 |
1.03e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 235 MMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlVAGLVLVNTMTIILFQFPTLKLLENVPLFTRTRLGMALMGMAQIGF 314
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTE-IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 315 MFTPEAFPLgwYLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFG-AAALYSLGFAIAPLAGGMMIENLNAQWLYGLC 393
Cdd:pfam07690 80 LFASSLWLL--LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGlVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180
....*....|....*....|....
gi 1472939696 394 FVLCLAMMGLYYLAQREQEMGEKE 417
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPK 181
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-175 |
1.40e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 32 LVGTLFARTSFFMAwPFLI-VFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAY---T 107
Cdd:cd17503 184 LLLSFLLGLGLFGA-MFLLpLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTlllA 262
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1472939696 108 GIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITL 175
Cdd:cd17503 263 FLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQ-IGDATALFNTIRQLGGSIGTALLATL 329
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
43-127 |
1.87e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 43 FMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMI 122
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94
|
....*
gi 1472939696 123 VLTGL 127
Cdd:cd17371 95 ALAGL 99
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
37-196 |
2.28e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.92 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 37 FARTSFFMAWPFLIvflyQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSN--- 113
Cdd:cd17345 17 LVRNNFSLAQPYLI----EQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsat 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 114 -QIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPdEKDRELALNVRYFLLNLGGAI-GPLIGITLAL---AHPQVLFIVTG 188
Cdd:cd17345 93 sSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFS-KKERGTWTSIWNISHNVGGGLvGPLAGLGLAIfgdGWWRGAFIFPA 171
|
....*...
gi 1472939696 189 IAYFLFGL 196
Cdd:cd17345 172 IIAIIVAV 179
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-168 |
2.88e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 27 PVWTVLVGTLFARTSFFMAWPFLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAY 106
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1472939696 107 ---TGIGLSNQIWQFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIG 168
Cdd:cd17321 249 lllALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEK-AGAASGILNTARQLGGALG 312
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-407 |
3.30e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 48 FLIVFLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGL 127
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 128 mrpmIEA---PGKAVIGDNLPDEKDRELALNVRYFLLNLGGAIGPLIGITLALAHP-QVLFIVTGIAYFLFGLWLLATLE 203
Cdd:cd17319 104 ----AEAgffPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGwRWAFIIEGLLGLLLAVLWWFYLR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 204 RkgrfqqpdrsllpnfsvtlrviskdsvFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQ---LVAGLVLVNTMTI 280
Cdd:cd17319 180 Q---------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQvglLAAIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 281 ILFQFPTLKLLenvpLFTRTRLGMALMGMAQIGFMFTPEAFPLGWYLACFVLS-MGEVIAFPTLNVQIDRLAPAHLRGSY 359
Cdd:cd17319 233 ILGGRLSDRLL----RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAgFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1472939696 360 FGAA-ALYSLGFAIAPLAGGMMIENLNAQWLYGLCFVLCLAMMGLYYLA 407
Cdd:cd17319 309 GGLInSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
302-417 |
3.47e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 39.48 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 302 LGMALMGMAQigfmfTPEAFPLGWYLACFVLSMgeviAFPTLNVQIDRLAPAHLRGSYFGA-AALYSLGFAIAPLAGGMM 380
Cdd:PRK05122 291 LGLLLLWLAP-----SPWMALIGAALTGFGFSL----VFPALGVEAVKRVPPQNRGAALGAySVFLDLSLGITGPLAGLV 361
|
90 100 110
....*....|....*....|....*....|....*..
gi 1472939696 381 IENLNAQWLYGLCFVLCLAMMGLYYLAQREQEMGEKE 417
Cdd:PRK05122 362 ASWFGYPSIFLAAALAALLGLALTWLLYRRAPRAVPE 398
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
30-175 |
4.07e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.17 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 30 TVLVGTLFARTSFFMAWPFLIVFLYQDY-HATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGAL---IATFA 105
Cdd:cd17476 179 IAVLLAVFLGWASFGIWVFYATQYFQNVrGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVaflVGPIL 258
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1472939696 106 YTGIGLSNQIW-QFFIMIVLTGLMRPMIEAPGKAVIGDNLPDEkDRELALNVRYFLLNLGGAIGPLIGITL 175
Cdd:cd17476 259 FATMPVHQTYWaQAFPAMIVAPFGMDFSFPAATIIASNAVPRE-YQGLAGSLVNTVVNYGISIGLGIAGTV 328
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
54-403 |
5.88e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 54 YQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPMIE 133
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 134 APGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIGITLALAHPQ-----VLFIVTGIAYFLFGLWLLATLerkgrf 208
Cdd:cd17316 108 PGASTYVAEFAPSKR-RGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrILFLIGALPALLALLLRRRTL------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 209 qqpdrsllpnfsvtlrviskdsvfvKMMLANFLMMFVYGQVESSLPQVIVRSGIADAAQlVAGLVLVNTMTIILFQFPTL 288
Cdd:cd17316 181 -------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPAT-SSLYLLLISLGALVGALIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 289 KLLEnvpLFTRTRLGMALMGMAQIGFMFTPEAFPLGWYLAC---FVLSMGEVIAFPTLNVQIDRLAPAHLRGSYFGAA-A 364
Cdd:cd17316 235 LLSD---RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLlllFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSyN 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1472939696 365 LYSLGFAIAPLAGGMMIEN---LNAQWLYGLCFVLCLAMMGL 403
Cdd:cd17316 312 LGRLGGGGAPPLIALLLAStggTGVPALILALLAIVALIVAL 353
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
56-373 |
7.85e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 56 DYHATATEVgAMLATSALVGSLTGL-YSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVL----TGLMRP 130
Cdd:cd17503 25 DLGASLDTV-QWVITSYLLALAIMIpLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILqgfgGGVLIP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 131 MieapGKAVIGDNLPDEKdRELALNVRYFLLNLGGAIGPLIG--ITLALAHPQVLFIVTGIAyfLFGLWLLATLErkgrf 208
Cdd:cd17503 104 L----AQTILLRIYPPEK-RGAAMGLVGLVILLAPAIGPTLGgwLTDNLSWRWIFYINLPIG--ILALLLAPLLD----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 209 qqpdrsllpnfsvtLRVIsKDSVFVKMMLANFLMMFVYGQVESSLPQVIVRSGIADAaqLVAGLVLVNT-MTIILFQFPT 287
Cdd:cd17503 172 --------------LRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA--FESGLVLAPGgLASAILSPLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 288 LKLLENVPLFTRTRLGMALMGMAQIGFMFTPEAFPLGW-YLACFVLSMGEVIAFPTLNVQIDRLAPAHLRGSyfgAAALY 366
Cdd:cd17503 235 GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLiILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGD---ATALF 311
|
330
....*....|.
gi 1472939696 367 S----LGFAIA 373
Cdd:cd17503 312 NtirqLGGSIG 322
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
52-199 |
9.45e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.10 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472939696 52 FLYQDYHATATEVGAMLATSALVGSLTGLYSGYLSDKFGRKWVMVSGALIATFAYTGIGLSNQIWQFFIMIVLTGLMRPM 131
Cdd:cd17396 25 SLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSF 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1472939696 132 IEAPGKAVIGDNLPdeKDRELALNVRYFLLNLGGAIGPLIgITLALAHP---QVLFIVTGIAYFLFGLWLL 199
Cdd:cd17396 105 LDTGTYPALMEAFP--KASGSANILVKAFVSFGQFLLPFI-IAFLAANNlwyGWSFIVPAAVLVLNALLLL 172
|
|
| |
