|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-365 |
4.41e-84 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 260.94 E-value: 4.41e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVS 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 165 ILGVIALISSLLLVPNNIPGRASAS--LRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWIL 242
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLglLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 243 LGYGVSVAIGNVWGGKLADKHGAvSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVVQKAeqy 322
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGR-RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA--- 316
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1453336589 323 tPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWIG 365
Cdd:cd17324 317 -PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
1-350 |
2.94e-64 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 209.95 E-value: 2.94e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 1 MPLALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTA 80
Cdd:PRK10091 1 MKKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 81 GNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETF 160
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 161 LAVSILGVIALISSLLLVPnNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSW 240
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVP-DIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 241 ILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAA--LATVLVMGIFAFGNvpGLQVYVVQK 318
Cdd:PRK10091 240 IMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMKTASliFAFICCAGLFALSA--PLQILLLQN 317
|
330 340 350
....*....|....*....|....*....|..
gi 1453336589 319 AEQytpGAVDVASGLNIaAFNIGIALGSIVGG 350
Cdd:PRK10091 318 AKG---GELLGAAGGQI-AFNLGSAIGAYCGG 345
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
3-365 |
3.08e-58 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 194.72 E-value: 3.08e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:PRK03545 89 VLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALISSLLLVPnNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWIL 242
Cdd:PRK03545 169 IGGGALITLLLLIKLLP-LLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 243 LGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASI-HYAALATVLVMGIFAFGnvPGLQVYVVQKAeq 321
Cdd:PRK03545 248 LLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEwHLSVLSIFWGIAIMCIG--LAMQVKVLKLA-- 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1453336589 322 ytPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWIG 365
Cdd:PRK03545 324 --PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVG 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-344 |
8.49e-44 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 155.52 E-value: 8.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALISSLLLVPNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWIL 242
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 243 LGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIhYAALATVLVMGIFAFGNVPGLQVYVvqkAEQY 322
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPLLQALV---AELA 325
|
330 340
....*....|....*....|..
gi 1453336589 323 TPGAVDVASGLNIAAFNIGIAL 344
Cdd:COG2814 326 PPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-361 |
1.33e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.68 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILG 167
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIALISSLLLVPNNIPGRASASLRDQMK------VLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWI 241
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLrsglrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 242 LLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLvMGIFAFGNVPGLQVYVvqkAEQ 321
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL-LGLGLGLVFPATLALL---ADI 316
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1453336589 322 YTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQT 361
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-364 |
3.02e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 111.51 E-value: 3.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALISSLLLV---PNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVS 239
Cdd:COG2223 165 LGILLLVVAVLAWLFLrdpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 240 WILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVvqkA 319
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV---P 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1453336589 320 EQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFL 366
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
4-252 |
4.84e-24 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 102.30 E-value: 4.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 4 ALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNV 83
Cdd:PRK10213 21 AVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 84 LAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAV 163
Cdd:PRK10213 101 LVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 164 SILGVIALISSLLLVPnNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILL 243
Cdd:PRK10213 181 AVMGVLCIFWIIKSLP-SLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLL 259
|
....*....
gi 1453336589 244 GYGVSVAIG 252
Cdd:PRK10213 260 SFGIASFVG 268
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-364 |
8.65e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.10 E-value: 8.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALIsslllvpnnipgrasaslrdqmkvlthPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWIL 242
Cdd:COG2271 170 LGLPGLLLAL---------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 243 LGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLT-ASIHYAALATVLVMGIFAFGNVPGLQVYVvqkAEQ 321
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWALA---AEL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1453336589 322 YTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-346 |
1.28e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVP-TIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAW 86
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 87 QAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSIL 166
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 167 GVIALISSLLLVP-----NNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWI 241
Cdd:pfam07690 161 SLLAAVLLLLPRPppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 242 LLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATV--LVMGIFAFGNVPGLQVYVVQKA 319
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLalLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....*..
gi 1453336589 320 EQYTPGavdVASGLNIAAFNIGIALGS 346
Cdd:pfam07690 321 PKEERG---TASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-350 |
6.25e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 98.80 E-value: 6.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFfSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILG 167
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIALISSLLLVpnnipgrasaslrdqMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQE----LAGFSPSAVSWILL 243
Cdd:cd17504 160 VLLAALVPLID---------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 244 GYGVSVAIGNVWGGKLADKHGA--VSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGI-FAFGNVPGLQVYVVQKAE 320
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPrrVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLgLAFASLPNIVVESVPPDR 304
|
330 340 350
....*....|....*....|....*....|
gi 1453336589 321 QytpgavDVASGLNIAAFNIGIALGSIVGG 350
Cdd:cd17504 305 T------GIATGMNTVLRTIGSAIGPAIAG 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
27-307 |
1.23e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 98.03 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVP-----NN 181
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlpeEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 182 IPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLAD 261
Cdd:cd17320 183 RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVR 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1453336589 262 KHGAVSALKFIFAALVVLLLVFQLTASIHYAAL-ATVLVMGIFAFGN 307
Cdd:cd17320 263 RFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLwPLVAPLFLIFFGF 309
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-358 |
4.99e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 93.40 E-value: 4.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQhFGWRETFLAVSILGVIALISSLLLVPNNIPGRA 186
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 187 SAS---LRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKH 263
Cdd:cd17474 182 SSSatkLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 264 gaVSALKFIFAALVVLLLVFQLTASIH--YAALATVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAVdvaSGLNIAAFNIG 341
Cdd:cd17474 262 --FGARRILVIGLLLYALSLLLLGFVPslALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA---SSLYNFVRFLG 336
|
330
....*....|....*..
gi 1453336589 342 IALGSIVGGQTVERYGL 358
Cdd:cd17474 337 QAVGPLLFGLLLEIFGL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-345 |
1.68e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 1.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:cd17321 20 PTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSlllvpnnipgra 186
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 187 saslrdqmkvlthPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGA- 265
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPr 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 266 -VSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAvdvASGLNIAAFNIGIAL 344
Cdd:cd17321 235 lVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA---ASGILNTARQLGGAL 311
|
.
gi 1453336589 345 G 345
Cdd:cd17321 312 G 312
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
8-361 |
4.72e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.57 E-value: 4.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILG 167
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIALISSLLL-VPNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELagfSPSAVSWILLGYG 246
Cdd:cd17489 161 LLALLLVFLVkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 247 VSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGnVPGLQVYVVQKAEQYTPGA 326
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL-FPALQALAVDLVPPHRRGA 316
|
330 340 350
....*....|....*....|....*....|....*
gi 1453336589 327 vdvASGLNIAAFNIGIALGSIVGGQTVERYGLAQT 361
Cdd:cd17489 317 ---ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-364 |
5.27e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.79 E-value: 5.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQH--FGWRETFLAVSI 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 166 LGVIALISSLLLVP--------NNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSA 237
Cdd:cd06174 161 LALLAAILLLLVVPdppesaraKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 238 VSWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVvq 317
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI-- 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1453336589 318 kAEQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:cd06174 319 -AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-179 |
1.22e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.85 E-value: 1.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLV 120
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1453336589 121 AKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVP 179
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-348 |
1.24e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 83.78 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILG 167
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIALISSLLLvpnnipgrasaslrdQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGV 247
Cdd:cd17503 161 ILALLLAPLL---------------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 248 SVAIGNVWGGKLADKHGAVSALKF---IFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVVQKAEQYTP 324
Cdd:cd17503 226 ASAILSPLVGRLLDKFGPRLLLLAgllLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIG 305
|
330 340
....*....|....*....|....
gi 1453336589 325 GAVDVASGLNIAAFNIGIALGSIV 348
Cdd:cd17503 306 DATALFNTIRQLGGSIGTALLATL 329
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-364 |
1.34e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.61 E-value: 1.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAhgvfFSIGSTIATSLVAK---EKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRET 159
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAG----IAVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 160 FLAVSILGVIALISSLLLVPNNIPGRASASLRDQMK-VLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQElAGFSPSAV 238
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRsLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 239 SWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLvMGIFAFGNVPGLQVYVVQK 318
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL-LGLGQGGLFPLALTLIGLR 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1453336589 319 AEqyTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:COG2807 332 AR--TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALL 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-315 |
4.29e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 75.70 E-value: 4.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 25 LVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLA 104
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 105 HGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLavsILGVIALISSLLLVPNnipg 184
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL---LGGVPPLILLPLLRGT---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 185 rasaslrdqmkvlthprlLMIYAITALGYGGVFTAFTFLAPMMQElAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHG 264
Cdd:cd17365 174 ------------------LLLWVTFFMGLLLVYLLNSWLPKLMVE-AGYSLSQALTITLLLNIGGVIGSLLLGWLADRFG 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1453336589 265 AVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYV 315
Cdd:cd17365 235 PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALA 285
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
20-348 |
4.59e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.07 E-value: 4.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 20 FVIVGLVPTIAQQ-LSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILAR 98
Cdd:cd17473 16 AAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 99 LLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQhFGWRETFLAVSILGVIALISSLLLV 178
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 179 PNNIPGRASASLRDQM-KVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGG 257
Cdd:cd17473 175 EPARKSKSAASPGAATaAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 258 KLADKHGAVSALKFIFAALVVLLLVFQLTASIhYAALATVLVMGIFAFGNVPGLQVYVVQKAeqyTPGAVDVASGLNIAA 337
Cdd:cd17473 255 RLKRRLGKRRLLAIGFALMALGFLLLALASGL-WVVLLGAILAGLGFGLLLPTLNSWAMSLV---PPELRGRAMGIVTSA 330
|
330
....*....|.
gi 1453336589 338 FNIGIALGSIV 348
Cdd:cd17473 331 FFLGQFLSPLV 341
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-350 |
9.84e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.91 E-value: 9.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNnipgra 186
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 187 saslrdqmkvlthprlLMIYAITALGYGGVFTAF-TFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGA 265
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLlTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 266 VSALKFIFAALVVLLLVFQLTASIHYAALAtVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAVDVASGLNIAAFNIGIALG 345
Cdd:cd17319 245 GARRLVIIIGLLLAAVGLLLAYLTTSPVVA-VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323
|
....*
gi 1453336589 346 SIVGG 350
Cdd:cd17319 324 PLLIG 328
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-252 |
3.19e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.54 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALISSLLLVPNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWIL 242
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250
....*....|
gi 1453336589 243 LGYGVSVAIG 252
Cdd:COG0477 254 LALLLLAALL 263
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
21-345 |
7.80e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 71.83 E-value: 7.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 21 VIVGLVPTIAQQLSiSLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLL 100
Cdd:cd17502 14 IVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 101 TGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALIssllLVPN 180
Cdd:cd17502 93 QGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALA----LLRT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 181 nipgrasaslrdqmkvlthprLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLA 260
Cdd:cd17502 169 ---------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 261 DKHGAVSALKFI--FAALVVLLLVFQLTASIHYAALatVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAVDVASGLNIAAF 338
Cdd:cd17502 228 SKTGRYKPLIVIgtILMSVGAGLLTTLTLDTSKWLL--IGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFR 305
|
....*..
gi 1453336589 339 NIGIALG 345
Cdd:cd17502 306 SLGGTLG 312
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
27-350 |
1.40e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.62 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNNI---- 182
Cdd:TIGR00895 121 GLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdflv 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 183 ----------------------------PGRASASLRDQMKVLTHPRL----LMIYAITALGYGGVFTAFTFLAPMMQEl 230
Cdd:TIGR00895 201 skrpetvrrivnaiapqmqaeaqsalpeQKSTQGTKRSVFKALFQGKTaritVLLWLLYFMLLVGVYFLTNWLPKLMVE- 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 231 AGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHG-AVSALKFIFAALVVLLLVFQLTASIhyAALATVLVMGIFAFGNVP 309
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGpRVTALLLLLGAVFAVLVGSTLFSPT--LLLLLGAIAGFFVNGGQS 357
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1453336589 310 GLQVYVvqkAEQYTPGAVDVASGLNIAAFNIGIALGSIVGG 350
Cdd:TIGR00895 358 GLYALM---ALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-364 |
6.11e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.50 E-value: 6.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVaKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLA 162
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 VSILGVIALISSLLLVPNNIPG------RASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPS 236
Cdd:COG0738 167 YLILAVLLLLLALLFLRSKLPEieeeeeEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 237 AVSWILLGYGVSVAIGNVWGGKLADKHGAVSALkFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGLQVYVV 316
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1453336589 317 QKAEQYTPGAVdvaSGLNIAAFnIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:COG0738 326 DGLGKRTAAAV---SAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLV 369
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-364 |
1.87e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.01 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLS--ISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFG----GLTVALVTGVPFGTFIGQHFGWRE 158
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 159 TFLAVSILGVIALisslllvpnnipgrasaslrdqmkvLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAV 238
Cdd:cd17316 161 LFLIGALPALLAL-------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 239 SWILLGYGVSVAIGNVWGGKLADKHG--AVSALKFIFAALVVLLLVFQLTASIHYAALATVLvMGIFAFGNVPGLQVYVv 316
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGrkKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-LSFFVGGVWGALYAYL- 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1453336589 317 qkAEQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:cd17316 294 --AELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
21-262 |
1.53e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 65.29 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 21 VIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLL 100
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 101 TGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPN 180
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 181 NIpgrasaslrdqmkvlthprLLMIYaiTALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLA 260
Cdd:cd17323 177 VL-------------------LLGLY--VGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLS 235
|
..
gi 1453336589 261 DK 262
Cdd:cd17323 236 DY 237
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
25-364 |
2.74e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.57 E-value: 2.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 25 LVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLA 104
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 105 HGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLL-----VP 179
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyreppAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 180 NNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKL 259
Cdd:cd17475 178 SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 260 ADKHGAVSALKFI----FAALVVLLLVFQLTASIHYAALATVL-VMGIFAFGNVPglqVYVVQKAEQYTPGAVDVASGLN 334
Cdd:cd17475 258 SDRVFGGRRRPVLvitaAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNG---LYLTLVAESAGPEQAGTALGLA 334
|
330 340 350
....*....|....*....|....*....|
gi 1453336589 335 IAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:cd17475 335 NTINFIGIAIGPPLFGLLVDATHSYAPAWL 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
3-357 |
3.19e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.21 E-value: 3.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAFAIGTTEFVivgLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:cd17355 6 AVTFLILILSWGIRYYFGV---FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGST-IATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFL 161
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 162 AVSILGVIALISSLLLVPNNIPGRASASLRDQMKVL----------THPRLLMIYAITALGYGGVFTAFTFLAPMmqELA 231
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstlkealrSASFWLLALAFFLCGFAVVGLIVHLVPYL--ADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 232 GFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPGL 311
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1453336589 312 QVYVvqkAEQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:cd17355 321 AALA---ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
8-364 |
8.87e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 8.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIAtSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILG 167
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIA--LISSLLLVPNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGY 245
Cdd:cd17478 160 LAValLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 246 GVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIhyAALATVLVMGIFAFGNVPGLQVYvvqkAEQYTPG 325
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI--WSYILLVLAGFLLFASFPVTVVL----AQELLPG 313
|
330 340 350
....*....|....*....|....*....|....*....
gi 1453336589 326 AVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:cd17478 314 NVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLI 352
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-357 |
1.95e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.81 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 8 LTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQ 87
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGvPFGTFIGQHFGWReTFLAVSILG 167
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGAL-PFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 168 VIALIsSLLLVPNNIPGRASASLRDQMKVLTHPRLLMIYaitALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGV 247
Cdd:cd17477 159 LLALV-PLLLTRRAAPEIEEAESISLRRLLRIAPLALLG---AFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 248 SVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAFGNVPglqVYVVQKAEQYTPGAV 327
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT---LALALAGDRLPGDEL 311
|
330 340 350
....*....|....*....|....*....|
gi 1453336589 328 DVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFG 341
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-357 |
2.07e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTI-AQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMP-----RKQLLLALMVLF 78
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 79 TAGNVLAWQAPGYET------LILARLLTGLAHGVFF----SIGSTIATSLVAKEKAASAIAIM--FGGLTVALVTGVPF 146
Cdd:COG2211 92 ALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNipysALGAELTPDYEERTRLSSWRFAFagLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 147 GTFIG-QHFGWRETFLAVSILGVIALISSLLLVPNNI-PGRASASLRDQMKVLTHPR-LLMIYAITALGYGGVFTAFTFL 223
Cdd:COG2211 172 AAFGGdAALGYRLTALIFAVLGLLAFLLTFFGTKERPvPEEEKVSLKESLKALLKNRpFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 224 APMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIF 303
Cdd:COG2211 252 LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1453336589 304 AFG----NVPGLQVYVVQKAEQYTPGAVD-VASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:COG2211 332 GLGailvLPWAMLADVVDYDEWKTGRRREgLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
26-364 |
3.65e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 61.08 E-value: 3.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 26 VPTI---AQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFT-AGNVLAWQAPGYETLILARLLT 101
Cdd:cd17490 16 VPFLspyAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 102 GLAHGVFFSIGSTIAtSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLV-PN 180
Cdd:cd17490 96 GIAAATWVSFTVLYA-SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKeER 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 181 NIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVF-TAFTFLAPMMQELaGFSPSAVSWILLGYGVSVAIGNVWGG-K 258
Cdd:cd17490 175 REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFsTTFGFTPLIAKQL-GASSFQLGLLSIIYLLPNALASLLSGtL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 259 LADKHGAVSALKFIFAALVVLLLVFQLTASIhYAALATVLVMGI---FAFGNVPGLQVYVVQKAEQYTpgavdvASGLNI 335
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNL-TLLYLLQALNGFgtgILFPLLMSLSIEGVPAEQRST------AMGFFQ 326
|
330 340
....*....|....*....|....*....
gi 1453336589 336 AAFNIGIALGSIVGGQTVERYGLAQTPWI 364
Cdd:cd17490 327 AIYALGMFLGPVLVGIISEAFGLQTGFFV 355
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
10-351 |
1.52e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 59.20 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 10 IGAFAIGTTEFVIVGLVPTIAQQLSISLPS-----AGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGvFFSIGSTIATSLVAKEKAASAIaimfGGLTVALVTGVPFGTFIG----QHFGWRETF 160
Cdd:cd17391 83 MAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWAL----GTLSTGVVAGTLIGPLLGgflaDLFGIRNVF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 161 LAVSILGVIALISSLLLVPNN---IPGRASASLRDQMKVLTHPRLLM-IYAITALGYGGVFTAFTFLAPMMQELAGFSP- 235
Cdd:cd17391 158 FITGGLLFLAFLLTLFFVKEDfkpVEKKKMVSTKEVWNSVPNPSLLIsLFVTTFIIQLANQSIEPILTLYIRQLMGDASn 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 236 -SAVSWILLGY-GVSVAIGNVWGGKLADKHGAVsalKFIFAALVVLLLVFQLTasihyAALATVLVMGIFAF-------G 306
Cdd:cd17391 238 lAFISGLVFSAtGVSSLLSAPRLGKLGDRIGHH---RILLGALLASALLYIPQ-----AFVQTPWQLGILRFllglatgG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1453336589 307 NVPGLQVYVVQKAEQYTPGAVdvaSGLNIAAFNIGIALGSIVGGQ 351
Cdd:cd17391 310 LLPAINSLLAKITPKEVAGRI---FGYNQSFQYLGNVAGPLLGSA 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-179 |
2.14e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 1 MPLALFALTIGAFAIGTTEFVIVGLVPTIAQQ-LSISLPSAGLLVSIYALGVAIGAPVLTALTGRM--PRKQLLLALMVL 77
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 78 FTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWR 157
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 1453336589 158 ETFLAVSILGVIALISSLLLVP 179
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
53-338 |
2.23e-09 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 58.85 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 53 IGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYET--------LILARLLTGLAHGVFFSIGSTIATSLVAKEK 124
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 125 ---AASAIAI-MFGGLTVALVTGVPFGTFIGQH----FGWRETFLAVSILGVIALISSLLLVPN----NIPGRASASLRD 192
Cdd:cd17367 135 rgfYSSFQYVtLIGGQLLALGVLLVLQHTLGEDqmaaWGWRIPFLLGGVLAVVVLWLRRGLEETesfeAIAESNEASAGT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 193 QMKVLTHPR-LLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGAVSALKF 271
Cdd:cd17367 215 LRELRRHPReLLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLF 294
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1453336589 272 IFAALVVLLLVFQLTASIH---YAALATVLVMGIFAFGNVpglQVYVVQKAEQYTPG----AVDVASGLNIAAF 338
Cdd:cd17367 295 FGIGGTLATVPLLSALDHTdspYTAFALVLVGLVFLSGYT---SINAVVKAELFPTHvralGVGLPYALAVAIF 365
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
5-357 |
3.69e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 57.70 E-value: 3.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd06180 1 LAGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVA-LVTGVPFGTFIGQHFGWRETFLAV 163
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGiALSGLLVPAGLGGGLSWRAGWLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 164 SILGVIALISSLLLVPNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAfTFLAPMMQELAGFSPSAVSWILL 243
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITA-TFLPLIARETGAGSLLAGLLWSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 244 GyGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLlvfqlTASIHYAALATVLVMGIFAFGNVPGLQVYVVQKAEQYT 323
Cdd:cd06180 240 F-GLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGV-----LLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELA 313
|
330 340 350
....*....|....*....|....*....|....
gi 1453336589 324 PGAVDVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:cd06180 314 PPAAPRALALMTASFGVGQILGPLLAGWLADATG 347
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
40-208 |
4.53e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.61 E-value: 4.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 40 AGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLahGVFFSIGSTIATSL 119
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 120 VAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNNIPGRASASLRDQM--KVL 197
Cdd:cd17472 112 TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKlkKLL 191
|
170
....*....|.
gi 1453336589 198 THPRLLMIYAI 208
Cdd:cd17472 192 KNKRLLRLDFS 202
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
5-357 |
6.36e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 6.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPT-IAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNV 83
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 84 LAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQhFGWRETFLAV 163
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 164 SILGVIALISSLLLVPNNIPGRASA----SLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVS 239
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAekteILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 240 WILLGYGVSVAIGNVWGGKLADKHGAVSALkfIFAALVVLLLVFQLTASIHYAALatVLVMGIFAFG---NVPGLQVYVV 316
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKIL--MIGILLFAIGFAVLAFANTLAVL--ILAMIVLTLGemlVFPAVQTLVA 315
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1453336589 317 QKAEqytPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:cd17329 316 ALAP---PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
26-365 |
8.25e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.85 E-value: 8.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 26 VPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVL-----FTAGNVLAWQAPGYETLILARLL 100
Cdd:cd06173 22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 101 TGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFL--AVSILGVIALISSLLLV 178
Cdd:cd06173 102 LGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 179 PNNIPGRASASLRDQMK-----VLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGN 253
Cdd:cd06173 182 PPAAPGESSSLLLRDLReglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 254 VWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIhYAALATVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAVdvaSGL 333
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV---FSV 337
|
330 340 350
....*....|....*....|....*....|..
gi 1453336589 334 NIAAFNIGIALGSIVGGQTVERYGLAQTPWIG 365
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-307 |
3.22e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.89 E-value: 3.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 40 AGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVfFSIGSTIATSL 119
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 120 VAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPnnipgrasaslrdqmkvlTH 199
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP------------------PL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 200 PRLLMIYAITALGYGGVFTAFTFLAPmmqELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGavSALKFIFAALVVL 279
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSLFLK---DRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRL--GERKLLRLGLLLA 251
|
250 260
....*....|....*....|....*...
gi 1453336589 280 LLVFQLTASIHYAALATVLVMgIFAFGN 307
Cdd:cd17330 252 IIGLLLLPFASSVPLLVLAAA-ILAFGT 278
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-262 |
4.15e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.55 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 19 EFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILAR 98
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 99 LLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHF-GWRETFLAVSILGVIALISSLLL 177
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 178 VPNNIPGRASASLRDQMKVLTHPRLLMI------YAITALGY-GGVFT--AFTFLAPM----MQELAGFSPSAVSWILLG 244
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSFLADLKAlaknpsFILSTLGFtAVSFVtgALAFWAPTfflrAFGVGDLSSADVGLIFGA 254
|
250
....*....|....*....
gi 1453336589 245 Y-GVSVAIGNVWGGKLADK 262
Cdd:cd17328 255 ItCIAGVLGVLLGGILADR 273
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-178 |
4.32e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.52 E-value: 4.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 9 TIGAFAIGTTEFVIVGLVPTIAQQLSISlpSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQA 88
Cdd:cd17489 200 ALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 89 PGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGV 168
Cdd:cd17489 278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
170
....*....|
gi 1453336589 169 IALISSLLLV 178
Cdd:cd17489 358 LALVLYIFLL 367
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
6-156 |
1.17e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 53.83 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 6 FALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLA 85
Cdd:TIGR01299 170 FVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFS 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 86 WQAPGYETLILARLLTGlahgvfFSIGSTIAT------SLVAKEKAASAIA-----IMFGGLTVALVTGVpfgtfIGQHF 154
Cdd:TIGR01299 250 SFVQGYGFFLFCRLLSG------FGIGGAIPIvfsyfaEFLAQEKRGEHLSwlcmfWMIGGIYAAAMAWA-----IIPHY 318
|
..
gi 1453336589 155 GW 156
Cdd:TIGR01299 319 GW 320
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
25-305 |
2.41e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 52.25 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 25 LVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQA-PGYETLILARLLTGL 103
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 104 AHGVFfSIGSTIATSLVAKEKAASAIAI-----MFGGLTVALVTGVPFGT--FIGQHFGWRETFLAVSILGVIALISSLL 176
Cdd:cd17341 101 AGANF-ASGQPWASFWFPKEKIGGAAGGiagagNMGVAVSQLLAPLIAGAivFDGGFVGWRNAFFVPGILLAIAAVLVLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 177 LVPNNIPGRASA--SLRDQMKVLTHPRLlmiyAITALGYG---GVFTAFTFLAPM-MQELAGFSPSAVSWILLGYGVSVA 250
Cdd:cd17341 180 FGDDLPTGKASAleFLKVQLAVLKNYRT----WILSLLYGvtfGSFVGFSNVLPTyFKTRFGLPLVTAGILAALFPLAGA 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1453336589 251 IGNVWGGKLADKHGAVSAL--KFIFAALVVLLLVFQLTASIHYAALATVLVMGIFAF 305
Cdd:cd17341 256 LARPAGGWLSDRFGGRRRLwwLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
27-306 |
3.57e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.89 E-value: 3.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHG 106
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNNIPGRA 186
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 187 SASLRDQ----MKVLTHPRLLMIYAITALGYGGVFTAFTFLA---PMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKL 259
Cdd:PRK11551 199 AAGAGKQrapvLRALFGEGRATATLLLWISYFFTLIVLYFLLnwlPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGAL 278
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1453336589 260 ADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALAtVLVMGIFAFG 306
Cdd:PRK11551 279 MDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLA-GFAAGLFVVG 324
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-365 |
7.09e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.78 E-value: 7.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 10 IGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAP 89
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 90 GYETLILARLLTGLAHGVFFSIGSTIATSLVaKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWreTFLAVSILGVI 169
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELS--WSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 170 ALISSLLLVPNNIPGRASASLRDQ--------MKVLTHPRLLMIYAITALGYGGVFTAF-TFLAPMMQELAGFSPSAVSW 240
Cdd:cd17333 160 YLLLAILILLTLFPELPSARNPQQsvgafsasASRLLRNPSIILGALALFLYVGAETAFsSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 241 ILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVmGIFAFGNVPGLQVYvvqkAE 320
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL-GLFMAALFPTILSL----GI 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1453336589 321 QYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQTPWIG 365
Cdd:cd17333 315 SNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLI 359
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
6-264 |
8.25e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 8.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 6 FALTIGAFAIGTTEFVIVGLV-PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVlPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIM-----FGGLTVALVTGVPFGTFIGqHFGWRET 159
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVqsgwaVGWLLATLLAALLFPLLPP-EIAWRVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 160 FLaVSILGVIALISSLLLVPNniPGRASASLRDQMKVLTHPRLLMIYA-----ITALG-------YGGVFTAFTFLAPMM 227
Cdd:cd17371 160 FL-LGALPALLVLFIRRFVKE--PPQWQAARAARRHFADRPSLRELFSppllrTTLLAsllatgaLGGYYGITTWLPSYL 236
|
250 260 270
....*....|....*....|....*....|....*..
gi 1453336589 228 QELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHG 264
Cdd:cd17371 237 TGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG 273
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
9-180 |
9.52e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 50.27 E-value: 9.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 9 TIGAFAIGTTEFVIVGLVPTIAQQLSISLPS--AGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAW 86
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 87 QAPGYETLILARLLTGLAHGVfFSIGSTIATSLVAKEKAASAIAIMF-----GGLTVALVTGVPFGTfigQHFGWRETFL 161
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVGL-ASVLVPLYISEIAPAKIRGALGTLNqlmitFGILLAYLLGLALSL---SPPGWWRLMF 158
|
170
....*....|....*....
gi 1453336589 162 AVSILGVIALISSLLLVPN 180
Cdd:cd17315 159 ALAAVPALLQLLLMFFLPE 177
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-178 |
1.05e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLV 120
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1453336589 121 AKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLV 178
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
6-156 |
2.48e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.26 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 6 FALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLA 85
Cdd:cd17439 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1453336589 86 WQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGW 156
Cdd:cd17439 82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
3-173 |
3.87e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 48.73 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFALTIGAF----AIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLF 78
Cdd:cd17358 2 LATFVANLGSFsfgiAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 79 TAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMfgglTVALVTGVPFGTFIGQHFGWRE 158
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLN----QLLVNIGILLGYVLGSFLPWRT 157
|
170
....*....|....*
gi 1453336589 159 TFLAVSILGVIALIS 173
Cdd:cd17358 158 LALIGAIPPVVFLIL 172
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
6-156 |
3.98e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 48.64 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 6 FALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLA 85
Cdd:cd17363 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1453336589 86 WQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIA-----IMFGGLTVALVTGVpfgtfIGQHFGW 156
Cdd:cd17363 82 SFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlcmfWMIGGLYASAMAWA-----IIPHYGW 152
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-172 |
4.05e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.32 E-value: 4.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 10 IGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAP 89
Cdd:cd17477 195 LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 90 GYETLILARL-LTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGV 168
Cdd:cd17477 275 GLPLALLVLLfLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
....
gi 1453336589 169 IALI 172
Cdd:cd17477 355 LFLL 358
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
41-301 |
5.50e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.23 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLA----LMVLFTAGnvLAWQAPGyeTLILARLLTGLAHgVFFSIGSTIA 116
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAfftlLGVLATAA--LFFVAPG--GLWLGLLLFVLAN-IGFEGSLVFY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 117 TSL---VAKEK---AASAIAIMFG--------GLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNNI 182
Cdd:COG2270 130 NAFlpdIATPEeigRVSGLGWALGylggvlllLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERP 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 183 PGRASAS----------LRDQMKVLTHPRLLMIYAITALGY-GGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAI 251
Cdd:COG2270 210 RPGPAPPrgavragfreLRRTLRELRRYRDLLRFLLAYFFYrDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1453336589 252 GNVWGGKLADKHGAVSALKF-IFAALVVLLLVFQLTASIHYAALATV--LVMG 301
Cdd:COG2270 290 GALLFGRLDDRIGPKRVILVsLVIWIVVCLAAYFLTTALAFWILGLLigLVMG 342
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-221 |
5.82e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 47.99 E-value: 5.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLtglaHG 106
Cdd:PRK11102 15 PVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFL----HG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 107 VFFSIGSTIATSLV----AKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVP--- 179
Cdd:PRK11102 91 LAAAAASVVINALMrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPetl 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1453336589 180 ---NNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFT 221
Cdd:PRK11102 171 pkeRRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLT 215
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-177 |
6.72e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 47.58 E-value: 6.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 45 SIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEK 124
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1453336589 125 --AASAIAIMFGGLTVALVTGVPFgtFIGQhfgWRETFLAVSILGVIALISSLLL 177
Cdd:cd17317 112 rsFVGILFGLFWALGYMLLALLAY--LIRD---WRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
7.06e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 7.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 2 PLALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAG 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 82 NVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFL 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 1453336589 162 AVSILGVIALISSLLL 177
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-180 |
1.02e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 47.42 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 26 VPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAH 105
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1453336589 106 GVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPN 180
Cdd:PRK10504 113 AMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPN 187
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-306 |
1.14e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.22 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 25 LVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLIlarlltgLA 104
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-------LG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 105 HGVFFSIGS----TIATSLVAK---EKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSI--LGVIALISSL 175
Cdd:cd17353 98 YGVLGGIGAgigyITPVSTAVKwfpDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIifLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 176 LLVP--------NNIPGRASASLRDQM---KVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLG 244
Cdd:cd17353 178 IRDPpkgwvppgVDPLANNAENSPRDYtprEMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSI 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1453336589 245 YGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGiFAFG 306
Cdd:cd17353 258 LSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIG-FCYG 318
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
5-179 |
1.26e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 47.22 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIA-----IMFGGLTVA-----LVTGVPFGTFIGQHF 154
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSwlcmfWMIGGLYASamawsIIPHYGWGFSMGTNY 160
|
170 180
....*....|....*....|....*...
gi 1453336589 155 ---GWReTFLAVSILGVIALISSLLLVP 179
Cdd:cd17438 161 hfhSWR-VFVIICALPCIASIIALKFMP 187
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
41-179 |
2.88e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.11 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL---AWQAPGYETLILARLLTGLAHGVfFSIGSTIAT 117
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLqgaAKGKWSVYQLIVGRVLVGIGVGG-ASVLAPMYI 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1453336589 118 SLVAKEKAASAIAIMFGgltVALVTGVPFGTFIGQHF-------GWReTFLAVSILGVIALISSLLLVP 179
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQ---LAITFGILLAYIFGLGLnktsnsdGWR-IPLGLQLVPALLLIIGLLFLP 192
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
25-275 |
4.64e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 25 LVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAwQAPGYETLILARLLTGLA 104
Cdd:cd17339 21 LLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLR-SLGGIALLFLGTALAGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 105 HGVffsiGSTIATSLVaKEKAASAIAIMFGGLTVALVTGVPFGTFI------GQHFGWRETFLAVSILGVIALISSLLLV 178
Cdd:cd17339 100 IAV----GNVLLPSLI-KRDFPRRVGLMTGLYTTSMNLGAALASGLsvplaqALGGGWRGALAIWALPALLALLIWLPQL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 179 PNNIPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQElAGFSPSAVSWILLGYGVSVAIGNVWGGK 258
Cdd:cd17339 175 RRRKRAAAAAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLVPI 253
|
250
....*....|....*..
gi 1453336589 259 LADKHGAVSALKFIFAA 275
Cdd:cd17339 254 LATRLKNQRPIVVLLAV 270
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-172 |
5.69e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 30 AQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFF 109
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1453336589 110 SIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALI 172
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALL 368
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
2-177 |
6.04e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 2 PLALFALTIGAFAIGTT--EFVIVGLVPTIAQQLSISLPSA---GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMV 76
Cdd:TIGR00898 86 PLKLSDLGLAATEPCLDgwEYSYDTFSSTIVTEWDLVCEDAwkvDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 77 LFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQhfgW 156
Cdd:TIGR00898 166 VTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---W 242
|
170 180
....*....|....*....|.
gi 1453336589 157 RETFLAVSILGVIALISSLLL 177
Cdd:TIGR00898 243 RWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
2-251 |
7.53e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.55 E-value: 7.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 2 PLALFALTIGAFAIGttefVIVGLVPTIAQQLSISLPSA----GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVL 77
Cdd:cd17388 2 IFILVTVLLDAMGIG----LIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 78 FTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIAtSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHfGWR 157
Cdd:cd17388 78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIA-DVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 158 ETFLAVSILGVIALISSLLLVPNNIPGR-------------ASASLRDQMKVLthPRLLMIYAITALGYGGVFTAFTFLa 224
Cdd:cd17388 156 APFLVAAGLNGLNFLLGLFVLPESLPPErrrafrwrranpfGSLRWLTGFPGL--LGLLAVFFLIQLIGQVPATTWVLF- 232
|
250 260
....*....|....*....|....*..
gi 1453336589 225 pmMQELAGFSPSAVSWILLGYGVSVAI 251
Cdd:cd17388 233 --TEDRFDWSPTMVGLSLAVFGLLHAL 257
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
12-357 |
8.10e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 44.28 E-value: 8.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 12 AFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGApvLTALTGRMPRKQ----LLLALMVLFTAGNVLAWQ 87
Cdd:pfam06779 2 TVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGA--LLASFAWRHGASrlrpALLAGLLATVLLLLAMAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 88 APGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTG---VPFGTFIGQHFGWreTFLAVS 164
Cdd:pfam06779 80 TSSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSgllVPLGLQLGLGGSS--LWYGAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 165 ILGVIALISSLLLVPNNIPGRASASLRdQMKVLTHPRLLMIYAIT--ALGYGGVFTAfTFLaPMMQELAGFSPSAVSWIL 242
Cdd:pfam06779 158 VLSAVLTLAVFPLLPRRAPRHASAPAP-AAKPLQRSLPLWILTLAygLAGFGYIITA-TFL-PAMARDGFGGPAAAALFW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 243 LGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQLTASIHYAALATVLVMGIFafgnvPGLQVYVVQKAEQY 322
Cdd:pfam06779 235 SLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTF-----MAITSLVMQLAREL 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1453336589 323 TPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:pfam06779 310 APPAPRRLLGLMTASFGIGQILGPLLASLLTAATG 344
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
5-156 |
2.09e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 43.36 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17440 1 FFVLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGW 156
Cdd:cd17440 81 SSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
22-234 |
2.88e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.70 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 22 IVGLvPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLT 101
Cdd:PRK10473 23 LVGL-PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 102 GLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPNN 181
Cdd:PRK10473 102 GIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKET 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1453336589 182 IPGRASASL---RDQMKVLTHPRLLMIYAITALGYGGVFTaFTFLAPM-MQELAGFS 234
Cdd:PRK10473 182 RPARAPAASskpRENSESLLNRFFLSRLVITTLSVTVILT-FVNTSPVlLMEQMGFS 237
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
3-177 |
3.12e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 3 LALFAlTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:cd17359 2 ISLVA-ALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASA-----IAIMFGGLTVALVT---GVPFGTFIGQHF 154
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLvslnqLMIVFGQLLAYIVNyliANAGGADWLGAE 160
|
170 180
....*....|....*....|...
gi 1453336589 155 GWRETFLAVSILGVIALISSLLL 177
Cdd:cd17359 161 GWRWMLGLEAIPAILFLLGMLFI 183
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
4-222 |
5.70e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.99 E-value: 5.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 4 ALFALTIGaFAIGTTEFVIVGLVPT-IAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGN 82
Cdd:PRK03893 21 AFSAAWLG-YLLDGFDFVLITLVLTeVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFla 162
Cdd:PRK03893 100 LACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF-- 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 163 vsILGVIALISSLLLvPNNIP--------GRASASLRDQMKVL--THPRLLMIyAITALGYGGVFTAFTF 222
Cdd:PRK03893 178 --FIGILPIIFALWL-RKNLPeaedwkekHAGKAPVRTMVDILyrGEHRIINI-LLTLAAAAALWFCFAG 243
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
64-215 |
9.48e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 9.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 64 RMPRKQLLLALMVLFTAGNVL-AWQAPGYETLILARLLTGLAHGVF---FSIGSTIATSLVAKEkAASAIAIMFGGLTVA 139
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLfAFLRNYWVLLLVGVVLLSLGAAAFpqlFALAREYADRSSGRD-ATLFNSVLRAAFSLA 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1453336589 140 LVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLLVPN-NIPGRASASLRDQMKVLTHPRLLMIYAITALGYGG 215
Cdd:cd17471 138 WVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSvKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAA 214
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
41-178 |
1.19e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.71 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVL---AWQAPGYETLILARLLTGLAHGVffsigSTIAT 117
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmflSKSAKSPELLIFGRFLVGIACGL-----STGFV 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1453336589 118 SLVAKEKAASAIAIMFGGLTvalVTGVPFGTFIGQHFGWRETF-------LAVSILGVIALISSLLLV 178
Cdd:cd17357 127 PMYLQEISPSELRGALGSLT---QIGVTLGILLGQVFGLPSVLgtetlwpYLLFFPGIPALLQLAALP 191
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
205-357 |
1.40e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 205 IYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLLLVFQ 284
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1453336589 285 LTASIhYAALATVLVMGIFAFGNVPGLQVYVvqkAEQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYG 357
Cdd:pfam07690 81 FASSL-WLLLVLRVLQGLGAGALFPAALALI---ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
9-107 |
1.82e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.95 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 9 TIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAG---LLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLA 85
Cdd:cd17360 3 GIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
|
90 100
....*....|....*....|..
gi 1453336589 86 WQAPGYETLILARLLTGLAHGV 107
Cdd:cd17360 83 AAAPNKEVLIVGRVLVGLGVGI 104
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
201-365 |
2.25e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 201 RLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSPSAVSWILLGYGVSVAIGNVWGGKLADKHGAVSALKFIFAALVVLL 280
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 281 LVFQLTASIHYAALATVLvMGIFAFGNVPGLQVYVvqkAEQYTPGAVDVASGLNIAAFNIGIALGSIVGGQTVERYGLAQ 360
Cdd:COG2814 90 LLCALAPSLWLLLAARFL-QGLGAGALFPAALALI---ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
....*
gi 1453336589 361 TPWIG 365
Cdd:COG2814 166 VFLVN 170
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
5-257 |
2.34e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.91 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 5 LFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGnVL 84
Cdd:cd17336 5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLG-CF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYetLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFG-TFIGQHFGWRETFLAV 163
Cdd:cd17336 84 LLALPHF--LFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGsFLLRIYVDFSRVPLGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 164 S---------------ILGVIALISSLLLvpnnipgrasaslrdqmkvLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQ 228
Cdd:cd17336 162 TpddprwigawwlgflILGILLLIVSIPL-------------------FFFPPIFILLLLAIVFESFAISGFSTFLPKYL 222
|
250 260 270
....*....|....*....|....*....|.
gi 1453336589 229 ELAGFSPSAVSWILLGYG--VSVAIGNVWGG 257
Cdd:cd17336 223 ETQFRLSASLASLLTGLIlvPGAALGILLGG 253
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
7-179 |
2.56e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 7 ALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALT--GRMPRKQLLLALMVLFTAGNVL 84
Cdd:cd17352 187 LLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 85 AWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPF-GTFIGQHFGWRETFLav 163
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIaGLLRDYTGDYDAAFY-- 344
|
170
....*....|....*.
gi 1453336589 164 sILGVIALISSLLLVP 179
Cdd:cd17352 345 -FCGACLLLSGVLLFL 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
7-177 |
3.11e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 7 ALTIGAFAIGTTEFVIVGLVPTI-AQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMP---RKQLLLALMVLFTAGN 82
Cdd:cd17319 183 GLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgaRRLVIIIGLLLAAVGL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 83 VLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIM-----FGGLTVALVTGVPFGTFIGQHFGwr 157
Cdd:cd17319 263 LLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInsggnLGGFVAPLLIGYLVDATGSYTAA-- 340
|
170 180
....*....|....*....|
gi 1453336589 158 etFLAVSILGVIALISSLLL 177
Cdd:cd17319 341 --FLFLAAVALLAALLVLLL 358
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
21-177 |
3.26e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 21 VIVGLVPTIAQQLS-ISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPG-YETLILAR 98
Cdd:cd17353 231 MLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGV 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1453336589 99 LLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFLAVSILGVIALISSLLL 177
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-361 |
3.46e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 27 PTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGR--MPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLA 104
Cdd:cd17335 21 SVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRfgKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 105 HGVFFSIGSTIATSLVAKEKAASAIAIMFGGL---TVALVTGVPFgTFIGQHFGWRETFLAVSILGVIALISSLLLVPNN 181
Cdd:cd17335 101 SAPVVPLVDSITLQYLGEERERYGKQRLWGSIgfgIAALLVGILI-DRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 182 IPGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELaGFSPSAVSWILLGYGVSVAIGNVWGGKLAD 261
Cdd:cd17335 180 KHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL-GGSKTLIGLLWTVGVVSEIPFFFFSSRLIQ 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 262 KHGAVsalKFIFAALVVLLLVFQLTASIHyaALATVLVMGIFAFGNVPGLQVYVVQKAEQYTPGAVDV-ASGLNIAAFN- 339
Cdd:cd17335 259 RFGHV---GLLYLGLLAYVVRWLLYSFLE--NPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRAtAQGLLQGLYFg 333
|
330 340
....*....|....*....|..
gi 1453336589 340 IGIALGSIVGGQTVERYGLAQT 361
Cdd:cd17335 334 LGGGLGSLIGGYLYEAFGARTT 355
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
4-175 |
4.48e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 4.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 4 ALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNV 83
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 84 LAWQAPGYETLILArLLTGLAHGVFFSIGSTIATSLVAkEKAASAIAIMFG-GLTVALVTGVPFGtFIGQHFGWRETFLA 162
Cdd:cd17478 276 LFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGlSFGLGGIGAPVLG-ALADAFGLESVLLI 352
|
170
....*....|...
gi 1453336589 163 VSILGVIALISSL 175
Cdd:cd17478 353 LALLPLLGALLAF 365
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
38-172 |
4.70e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 38 PSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIAT 117
Cdd:cd06179 32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASE 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1453336589 118 SLVAKEKAAsaiaiMFGGLTVALVTGVPFGTFIGQHF------GWRETFLAVSILGVIALI 172
Cdd:cd06179 112 LVPNKYRGL-----VQGVVNLVASPGSALGPLIAGALveanaaGWRWIFYINAIFNALALI 167
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
41-185 |
4.98e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 38.61 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 41 GLLVSIYALGVAIGAPVLTALTGRMPRKQLLL---ALMVLFTAGNVLAwqaPGYETLILARLLTGLAHGvffsiGSTIAT 117
Cdd:cd17377 42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLtglALDILFAYFNALA---PSYEFFAVSRFLVGVMNG-----GMSLVA 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1453336589 118 SLVAKE---KAASAIAIMFGGLTVALvtGVPFGTFIGQHF-GWRETFLAVSILGVIALISSLLlvpnnIPGR 185
Cdd:cd17377 114 FVLLNEcvgKSYWALAGSLGGLFFAV--GIAQYALLGYFIrSWRTLAVVVNLQGTLVFLLSLF-----IPGR 178
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
2-240 |
6.35e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 38.65 E-value: 6.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 2 PLALFALTIGAFAigTTEFVIVGLVPTIAQ-QLSISLPSAGllVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTA 80
Cdd:PRK15403 18 PMALILYDFAAYL--TTDLIQPGIINVVRDfNADVSLAPAS--VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 81 GNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETF 160
Cdd:PRK15403 94 ACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 161 LAVSILGVIALISSLLLVPNNI-----PGRASASLRDQMKVLTHPRLLMIYAITALGYGGVFTAFTFLAPMMQELAGFSP 235
Cdd:PRK15403 174 AIIAVMGLIAFVGLLLAMPETVkrgavPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTT 253
|
....*
gi 1453336589 236 SAVSW 240
Cdd:PRK15403 254 SQFAW 258
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
70-155 |
6.66e-03 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 38.24 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 70 LLLALMVLFTAGNVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLVAKEKAASAIAIMFGGLTVALVTGVPFGTF 149
Cdd:cd17465 258 LQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGL 337
|
....*.
gi 1453336589 150 IGQHFG 155
Cdd:cd17465 338 LHDYFG 343
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
2-175 |
9.08e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 37.91 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 2 PLALFALTIGAFAIGTTEFVIVGLVPTIAQQLSISLPSAGLLVSIYALGVAIGAPVLTALTGRMPRKQLLLALMVLFTAG 81
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453336589 82 NVLAWQAPGYETLILARLLTGLAHGVFFSIGSTIATSLvAKEKAASAIAIMFGGLTVALVTGVPFGTFIGQHFGWRETFL 161
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 1453336589 162 AVSILGVIALISSL 175
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| |
