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Conserved domains on  [gi|1462843227|emb|SXF32736|]
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permease of ferrichrome ABC transporter [Klebsiella variicola]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.39e-83

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 255.77  E-value: 1.39e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  44 SLSRGSFPLPASTLARALLAPQDmGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDG-DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 124 VLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRP---RFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLsplRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 201 AGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843227 281 MAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.39e-83

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 255.77  E-value: 1.39e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  44 SLSRGSFPLPASTLARALLAPQDmGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDG-DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 124 VLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRP---RFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLsplRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 201 AGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843227 281 MAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 42-345 2.43e-68

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 216.62  E-value: 2.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  42 LYSLSRGSFPLPASTLARALLAPQDmgEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGAS 121
Cdd:pfam01032   7 LLSLFIGAVKISPSDVFSALLGGDD--SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 122 IVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRP---RFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMI 198
Cdd:pfam01032  85 LGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGAsplRLILAGIAVSALLSALTSLLLLLLNPEALQSILF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 199 WLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFV 278
Cdd:pfam01032 165 WLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFV 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843227 279 GLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWR 345
Cdd:pfam01032 245 GLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
75-347 6.96e-54

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 187.74  E-value: 6.96e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  75 LFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWRPLAGMVGGVAVALLV 154
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALI 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 155 LTLAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARA 232
Cdd:PRK10577  473 LLLARrgGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRW 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 233 ADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVT 312
Cdd:PRK10577  552 LDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLA 631

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1462843227 313 DTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:PRK10577  632 DWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-343 2.85e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 134.61  E-value: 2.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  83 ILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCS 162
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 163 RPRFILIGIGVSWTLAAAVG-IFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDR 241
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGvILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 242 TAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLaFA 321
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                         250       260
                  ....*....|....*....|..
gi 1462843227 322 PLQIPAGIVIALVGCPFFVVLL 343
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 44-347 1.39e-83

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 255.77  E-value: 1.39e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  44 SLSRGSFPLPASTLARALLAPQDmGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDG-DPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 124 VLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRP---RFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWL 200
Cdd:COG0609    80 AVLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLsplRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 201 AGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGL 280
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843227 281 MAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 42-345 2.43e-68

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 216.62  E-value: 2.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  42 LYSLSRGSFPLPASTLARALLAPQDmgEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGAS 121
Cdd:pfam01032   7 LLSLFIGAVKISPSDVFSALLGGDD--SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 122 IVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRP---RFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMI 198
Cdd:pfam01032  85 LGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGAsplRLILAGIAVSALLSALTSLLLLLLNPEALQSILF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 199 WLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFV 278
Cdd:pfam01032 165 WLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFV 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843227 279 GLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWR 345
Cdd:pfam01032 245 GLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 1-347 6.72e-68

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 216.53  E-value: 6.72e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227   1 MTRAVHRAgfrpLVIASRQLLLRPAALNIAAIMMLMLLALGLYSLSRGSFPLPASTLARALLAPQDMGEqpRFILFDIRL 80
Cdd:COG4779     1 MSATSTRV----LRVGRVSLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGA--SFVVLELRL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  81 PRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLvWRPLAGMVGGVAVALLVLTLA-- 158
Cdd:COG4779    75 PRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGL-AVALGALAGGLATALLVYLLAwr 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 159 RDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALL 238
Cdd:COG4779   154 GGVSGYRLILVGIGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLEL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 239 GDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLcGSALIGALLVLVTDTLGRL 318
Cdd:COG4779   234 GDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLL-PSALVGALLLLAADLVAQH 312

                         330       340
                  ....*....|....*....|....*....
gi 1462843227 319 AFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:COG4779   313 LLAPVQLPVGVVTGALGGPYLLWLLIREN 341
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
75-347 6.96e-54

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 187.74  E-value: 6.96e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  75 LFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWRPLAGMVGGVAVALLV 154
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALI 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 155 LTLAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARA 232
Cdd:PRK10577  473 LLLARrgGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRW 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 233 ADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVT 312
Cdd:PRK10577  552 LDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLA 631

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1462843227 313 DTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:PRK10577  632 DWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
42-347 3.23e-49

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 167.53  E-value: 3.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  42 LYSLSRGSFPLPASTLARALLApqdmGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGAS 121
Cdd:PRK09777   18 LLSLRMGVIPLPWRALLTDWQA----GDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAAS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 122 IVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVrDVQTAMIWLA 201
Cdd:PRK09777   94 LASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTHQPMKLALTGVALSALWASLTDYLMLSRPQ-DINNALLWLT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 202 GSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLM 281
Cdd:PRK09777  173 GSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLV 252

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1462843227 282 APHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:PRK09777  253 VPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
btuC PRK09535
cobalamin ABC transporter permease BtuC;
8-346 4.72e-43

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 152.60  E-value: 4.72e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227   8 AGFRPLVIASRQLLLrpAALNIAAIMMLMLLALGLYSLSRGSFPLPASTLARALLAPQDMGEQPRFILFDIRLPRILMAL 87
Cdd:PRK09535   26 AAIGPVRIPPRTVAM--ALLNAVAVPVGVAVTTHGVPVLSVGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  88 LCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLfFPAVGLVWRPLAGMVGGVAVALLVLTLA-RDCSRPRF 166
Cdd:PRK09535  104 TVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIV-LPLAVPFGLQAAAFAGALVAAFGVYAIAtENGRTPVA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 167 ILIGIGVS-WTLAAAVGIFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIG 245
Cdd:PRK09535  183 TLLLAGVAvQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHT 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 246 LGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLafAPLQI 325
Cdd:PRK09535  263 LGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEV 340

                         330       340
                  ....*....|....*....|.
gi 1462843227 326 PAGIVIALVGCPFFVVLLWRR 346
Cdd:PRK09535  341 PVGIVTAALGAPFFLYLLRTR 361
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
41-349 6.67e-42

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 154.61  E-value: 6.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  41 GLYSLSRGSFPLPASTLARALLAPQDMGEQpRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGA 120
Cdd:PRK10577   25 LALTLTQLSAALPLSQWLQALWGPDADDLE-QLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 121 SIVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLA--RDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAMI 198
Cdd:PRK10577  104 QLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAggKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQY-LQGLFL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 199 WLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFV 278
Cdd:PRK10577  183 WGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFI 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1462843227 279 GLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRL--AFAPLQIPAGIVIALVGCPFFVVLLWRRRDA 349
Cdd:PRK10577  263 GLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLlaGVGGELLPTGAVTALIGAPLLLWLLPRLRSA 335
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
49-347 1.03e-38

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 140.22  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  49 SFPLPASTLARALLaPQDMGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASivvLALV 128
Cdd:PRK11228   22 AIPISAADALNALL-PGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAA---LAMA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 129 LffpAVGLVWRPLAGM-------VGGVAVALLVLTLARDCS----RPRFILIGIGVSWTLAAAVGIFMTTADVRdVQTAM 197
Cdd:PRK11228   98 L---TSALSPTPFAGYslafiaaCGGGLSWLLVMTAGGGWRhthdRNRLILAGIALSALCMALTRITLLLAEDH-AYGIF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 198 IWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGF 277
Cdd:PRK11228  174 YWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAF 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 278 VGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:PRK11228  254 IGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRRG 323
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 69-349 4.24e-38

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 138.45  E-value: 4.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  69 EQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWR-PLAGMVGG 147
Cdd:COG4139    45 EAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLlSLAAIAGA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 148 VAVALLVLTLARD-CSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCwALPGAIIL 226
Cdd:COG4139   125 LLVTLLLLAFARRrLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLA-LLPVLLWL 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 227 FCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGA 306
Cdd:COG4139   204 CLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGA 283

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1462843227 307 LLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRRDA 349
Cdd:COG4139   284 ALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRRKI 326
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-343 2.85e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 134.61  E-value: 2.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  83 ILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTLARDCS 162
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 163 RPRFILIGIGVSWTLAAAVG-IFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDR 241
Cdd:cd06550    81 LSPSKLILIGIVLSAFFSAGvILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 242 TAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLaFA 321
Cdd:cd06550   161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT-LL 239

                         250       260
                  ....*....|....*....|..
gi 1462843227 322 PLQIPAGIVIALVGCPFFVVLL 343
Cdd:cd06550   240 PSELPVGPVTALLGAPYFLYLL 261
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 68-349 9.10e-35

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 129.69  E-value: 9.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  68 GEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWR-PLAGMVG 146
Cdd:PRK03784   47 SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWAlSLCAIAG 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 147 GVAVALLVLTLAR--DCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAfcWALPGAI 224
Cdd:PRK03784  127 ALLITLILLRFARrhRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLM--LALLPVL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 225 I-LFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLCGSAL 303
Cdd:PRK03784  205 IwLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCAL 284

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1462843227 304 IGALLVLVTDTLGRLAFAPLQIPAGIVIALVGCPFFVVLLWRRRDA 349
Cdd:PRK03784  285 AGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSHRA 330
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
20-345 6.92e-32

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 122.13  E-value: 6.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  20 LLLRPAALNIAAIMMLMLLALGLYSLSRGSFPLPASTLARALlapqdMGEQPR---FILFDIRLPRILMALLCGAMLGLA 96
Cdd:PRK10440    2 IYVSRRLLITCLLLLAACVAAGLWGLRSGAVTLETSQVFAAL-----MGDAPRsmtMVVTEWRLPRVLMALLIGAALGVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  97 GTAMQSITRNGLADPGLIGVKEGA-SIVVLALVLFfpAVGLVWRPLAGMVGGVAVALLVLTLA--RDCSRPRFILIGIGV 173
Cdd:PRK10440   77 GAIFQSLMRNPLGSPDVMGFNTGAwSGVLVAMVLF--GQDLTAIALAAMAGGIVTSLLVWLLAwrNGIDTFRLIIIGIGV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 174 SWTLAAAVGIFMTTADVRDVQTAMIWLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQL 253
Cdd:PRK10440  155 RAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 254 TMLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFVLRGGQVSLLcGSALIGALLVLVTDTLGRLAFAPLQIPAGIVIAL 333
Cdd:PRK10440  235 RLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGTARWGLT-QAALCGALLLLAADLCAQQLFMPYQLPVGVVTVS 313

                         330
                  ....*....|..
gi 1462843227 334 VGCPFFVVLLWR 345
Cdd:PRK10440  314 LGGIYLIVLLIQ 325
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
44-347 6.39e-28

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 111.34  E-value: 6.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227  44 SLSRGSFPLPASTLARALLApqDMGEQPRFILFDIRLPRILMALLCGAMLGLAGTAMQSITRNGLADPGLIGVKEGASIV 123
Cdd:PRK10441   27 SLLIGAKSLPASVVLEALSG--TCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 124 VLALVLFFPAVGLVWRPLAGMVGGVAVALLVLTL----ARDCSRPRFILIGIGVSWTL-AAAVGIFMTTADVRDvqTAMI 198
Cdd:PRK10441  105 IVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTgsqgGGQLSPVRLTLAGVALAAVLeGLTSGIALLNPDVYD--QLRF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843227 199 WLAGSLQAATWPLLAVAFCWALPGAIILFCTARAADVALLGDRTAIGLGVRLQQLTMLRFFAPVLLTSASVSCVGSLGFV 278
Cdd:PRK10441  183 WQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFI 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1462843227 279 GLMAPHMARFVLRGGQVSLLCGSALIGALLVLVTDTLGRLaFAPLQIPAGIVIALVGCPFFVVLLWRRR 347
Cdd:PRK10441  263 GLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRL-LVPGELRVSVVSAFIGAPVLIFLVRRKT 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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