|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-548 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 736.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 1 MDSQRNLLIIALLFVSFMIWQAWEQDKNPQPQqqttqttttaagsaadqgvPASGQGKLITVKTDVLELTINTNGGDIEQ 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAA-------------------QAPAPQARITVETDVLRLSIDTKGGRIDD 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 81 ALLLAYPKTLKSTEPFQLLETTPQFVYQAQSGLTGRDGPDNPANGPRPLYSVDKEAFVLADGQDEIVIPLTYTDKAGNVF 160
Cdd:PRK01318 62 LLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPDRTLYTADGDSLVLADGQNELPVTLTWTNGNGLTF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 161 TKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTAAlptsrdtqtgGLSTMHTFRGAAFSTSDTKYEKYKFDTILD 240
Cdd:PRK01318 142 TKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKRTGS----------SNFASYTFHGGAIGTPDEKYEKYTYKDIDD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 241 NENlnVSTKNGWVAMLQQYFTTAWVPqNNGTNNFYTANLGNGIVAIGYKSQPVLVQPGQTDKLQSVLWVGPAIQDKMA-A 319
Cdd:PRK01318 212 NLN--ISSKGGWVAILDKYFATALIP-QNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 320 VAPHLDLTVDYGWLWFISQPLFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGD 399
Cdd:PRK01318 289 IAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKD 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 400 DKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFILWIHDLSAQDPYYIL-----PIIMGAT 474
Cdd:PRK01318 369 DPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGIT 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1440323448 475 MFFIQKMSPTTvTDPMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS 548
Cdd:PRK01318 449 MFLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAANKKKK 521
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-352 |
4.94e-122 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 363.19 E-value: 4.94e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 3 SQRNLLIIALLFVSFMIWQAWEQDKNPQPQQQTTQTTTTAAGSAADQGVPASG------------------QGKLITVKT 64
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPKPPAAAQEASAASATAAATSAAApaaadapsaaaaadaaaaTAKRITVET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 65 DVLELTINTNGGDIEQALLLAYPKTLKSTE-PFQLLETTPQFVYQAQSGLTGRDGPDNPANGPRPLYSVDKEAFVLADGQ 143
Cdd:TIGR03593 81 DVLRASISTKGGDIDSLELKKYKETLDKDSpPVLLLSDGAERLYVAQSGLIGANGADLALPGHRTVWQAEGGEYTLTPGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 144 deIVIPLTYTDKAGNVFTKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTaalptSRDTQTGGLSTMHTFRGAAF 223
Cdd:TIGR03593 161 --LPVTLTWDNSNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRD-----LSPTEKSTYFLHETFTGAAY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 224 STSDTKYEKYKFDTIlDNENLNVSTK--NGWVAMLQQYFTTAWVPQNNG---TNNFYTANLGNGIVAIGYKSQPVLVQPG 298
Cdd:TIGR03593 234 YTDGEKYQKVSFKDI-EKKKLNVETKggAGWVGMLQHYFASAWIPPAGSdgtTAFYYGRKLGNNVYIAGFVSPVVTVAPG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1440323448 299 QTDKLQSVLWVGPAIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKFIHSFLG 352
Cdd:TIGR03593 313 QSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
328-539 |
1.11e-119 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 351.34 E-value: 1.11e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 328 VDYGWLWFISQPLFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQE 407
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 408 MMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIHDLSAQDPYYI-LPIIMGATMFFIQKMSPTTV 486
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1440323448 487 TDPMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEKRG 539
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
60-330 |
4.01e-100 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 303.43 E-value: 4.01e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 60 ITVKTDVLELTINTNGGDIEQALLLAYPKTLKS-TEPFQLLETTPQFVYQAQSGLTGRDGPDNPAngPRPLYSVDKEAFV 138
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDdSPPVVLLSPSGGRTYVAQSGLIGAGGPDLPP--HDTVFTAEGGSYT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 139 LADGQDEIVIPLTYTDKAGNVFTKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTaalPTSRDTQtgglSTMHTF 218
Cdd:pfam14849 79 LADGTDELPVTLTWDNGNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRD---PGEPEGS----SFYITY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 219 RGAAFSTSDTKYEKYKFDTILDNENLNVSTK--NGWVAMLQQYFTTAWVPQNNGT-NNFYTANLGNGIVAIGYKSQPVLV 295
Cdd:pfam14849 152 TGAAGSTDEGKYQKVSFDDIEKGGKLKVDTTtgGGWVAMTQHYFLSAWIPDQDGTtNEFYTRFLGGNLYQAGYISPAVTV 231
|
250 260 270
....*....|....*....|....*....|....*
gi 1440323448 296 QPGQTDKLQSVLWVGPAIQDKMAAVAPHLDLTVDY 330
Cdd:pfam14849 232 APGASATVTARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
355-533 |
9.02e-97 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 291.59 E-value: 9.02e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 355 GFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFL 434
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 435 ALYYMLSASVELRHAPFILWIHDLSAQDPYYILPIIMGATMFFIQKMSPTTVT--DPMQQKIMTFMPVIFTVFFLWFPSG 512
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 1440323448 513 LVVYYIVSNLVTIIQQQLIYR 533
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-548 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 736.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 1 MDSQRNLLIIALLFVSFMIWQAWEQDKNPQPQqqttqttttaagsaadqgvPASGQGKLITVKTDVLELTINTNGGDIEQ 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAA-------------------QAPAPQARITVETDVLRLSIDTKGGRIDD 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 81 ALLLAYPKTLKSTEPFQLLETTPQFVYQAQSGLTGRDGPDNPANGPRPLYSVDKEAFVLADGQDEIVIPLTYTDKAGNVF 160
Cdd:PRK01318 62 LLLKKYKETLDSSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPDRTLYTADGDSLVLADGQNELPVTLTWTNGNGLTF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 161 TKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTAAlptsrdtqtgGLSTMHTFRGAAFSTSDTKYEKYKFDTILD 240
Cdd:PRK01318 142 TKTYTLDRGDYMFTVEYSVNNNSGAPVNLSPYGQLKRTGS----------SNFASYTFHGGAIGTPDEKYEKYTYKDIDD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 241 NENlnVSTKNGWVAMLQQYFTTAWVPqNNGTNNFYTANLGNGIVAIGYKSQPVLVQPGQTDKLQSVLWVGPAIQDKMA-A 319
Cdd:PRK01318 212 NLN--ISSKGGWVAILDKYFATALIP-QNGQNNFYSKNLGNGLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 320 VAPHLDLTVDYGWLWFISQPLFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGD 399
Cdd:PRK01318 289 IAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKD 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 400 DKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFILWIHDLSAQDPYYIL-----PIIMGAT 474
Cdd:PRK01318 369 DPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVLLVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGIT 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1440323448 475 MFFIQKMSPTTvTDPMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS 548
Cdd:PRK01318 449 MFLQQKLNPTP-TDPMQAKIMKFMPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAANKKKK 521
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-352 |
4.94e-122 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 363.19 E-value: 4.94e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 3 SQRNLLIIALLFVSFMIWQAWEQDKNPQPQQQTTQTTTTAAGSAADQGVPASG------------------QGKLITVKT 64
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPKPPAAAQEASAASATAAATSAAApaaadapsaaaaadaaaaTAKRITVET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 65 DVLELTINTNGGDIEQALLLAYPKTLKSTE-PFQLLETTPQFVYQAQSGLTGRDGPDNPANGPRPLYSVDKEAFVLADGQ 143
Cdd:TIGR03593 81 DVLRASISTKGGDIDSLELKKYKETLDKDSpPVLLLSDGAERLYVAQSGLIGANGADLALPGHRTVWQAEGGEYTLTPGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 144 deIVIPLTYTDKAGNVFTKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTaalptSRDTQTGGLSTMHTFRGAAF 223
Cdd:TIGR03593 161 --LPVTLTWDNSNGVTVTKTYTFDRDSYLIDVEYKVTNNGDAPVSLSLYGQLKRD-----LSPTEKSTYFLHETFTGAAY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 224 STSDTKYEKYKFDTIlDNENLNVSTK--NGWVAMLQQYFTTAWVPQNNG---TNNFYTANLGNGIVAIGYKSQPVLVQPG 298
Cdd:TIGR03593 234 YTDGEKYQKVSFKDI-EKKKLNVETKggAGWVGMLQHYFASAWIPPAGSdgtTAFYYGRKLGNNVYIAGFVSPVVTVAPG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1440323448 299 QTDKLQSVLWVGPAIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKFIHSFLG 352
Cdd:TIGR03593 313 QSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
328-539 |
1.11e-119 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 351.34 E-value: 1.11e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 328 VDYGWLWFISQPLFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQE 407
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 408 MMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIHDLSAQDPYYI-LPIIMGATMFFIQKMSPTTV 486
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPF-LGIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1440323448 487 TDPMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEKRG 539
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
353-531 |
5.36e-101 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 302.48 E-value: 5.36e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 353 NWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPI 432
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 433 FLALYYMLSASVELRHAPFiLWIHDLSAQDPYYILPIIMGATMFFIQKMSPTTVTDPMQQKIMT-FMPVIFTVFFLWFPS 511
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPF-LWIIDLSSPDPYYILPILMGVTMFLQQKLSPKGPPDPAQQKMMMyFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 1440323448 512 GLVVYYIVSNLVTIIQQQLI 531
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
60-330 |
4.01e-100 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 303.43 E-value: 4.01e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 60 ITVKTDVLELTINTNGGDIEQALLLAYPKTLKS-TEPFQLLETTPQFVYQAQSGLTGRDGPDNPAngPRPLYSVDKEAFV 138
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDdSPPVVLLSPSGGRTYVAQSGLIGAGGPDLPP--HDTVFTAEGGSYT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 139 LADGQDEIVIPLTYTDKAGNVFTKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTaalPTSRDTQtgglSTMHTF 218
Cdd:pfam14849 79 LADGTDELPVTLTWDNGNGVTFTKTYTFDRGSYLIDVTYEVENTSGAPVTLQPYGQLVRD---PGEPEGS----SFYITY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 219 RGAAFSTSDTKYEKYKFDTILDNENLNVSTK--NGWVAMLQQYFTTAWVPQNNGT-NNFYTANLGNGIVAIGYKSQPVLV 295
Cdd:pfam14849 152 TGAAGSTDEGKYQKVSFDDIEKGGKLKVDTTtgGGWVAMTQHYFLSAWIPDQDGTtNEFYTRFLGGNLYQAGYISPAVTV 231
|
250 260 270
....*....|....*....|....*....|....*
gi 1440323448 296 QPGQTDKLQSVLWVGPAIQDKMAAVAPHLDLTVDY 330
Cdd:pfam14849 232 APGASATVTARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
354-533 |
7.13e-98 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 294.76 E-value: 7.13e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 354 WGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIF 433
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 434 LALYYMLSASVELRHAPFILWIHDLSAQDP-----YYILPIIMGATMFFIQKMSPTTVTDPMQQKIMT--FMPVIFTVFF 506
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMlyFMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 1440323448 507 LWFPSGLVVYYIVSNLVTIIQQQLIYR 533
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
355-533 |
9.02e-97 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 291.59 E-value: 9.02e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 355 GFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFL 434
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 435 ALYYMLSASVELRHAPFILWIHDLSAQDPYYILPIIMGATMFFIQKMSPTTVT--DPMQQKIMTFMPVIFTVFFLWFPSG 512
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqAPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 1440323448 513 LVVYYIVSNLVTIIQQQLIYR 533
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
355-533 |
3.91e-84 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 259.41 E-value: 3.91e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 355 GFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDK------QRQSQEMMALYKAEKVNPLGGCFPLII 428
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKAskdkvqQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 429 QMPIFLALYYMLSASVELRHAPFiLWIHDLSAQDPYYILPIIMGATMFFIQKMSPTTVT-----DPMQQKIMTFMPVIFT 503
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTF-LWFFDLGQPDYLYILPFVAGITTYFQFKMTMSHQQqmqmmQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 1440323448 504 VFFLWFPSGLVVYYIVSNLVTIIQQQLIYR 533
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
58-330 |
7.35e-66 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 214.48 E-value: 7.35e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 58 KLITVKTDVLELTINTNGGDIEQALLLAYPKTLKSTEPFQLLEttPQFVYQAQSGLTGRDGPDNPANgpRPLYSVDKEAF 137
Cdd:cd19961 1 KRITVETDLLKASISTKGGRIKSVELKKYKETLPDSKPVELLS--PDGPYVAQLGLIGADGPLIPTA--DLLFTADSGSY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 138 vlaDGQDEIVIPLTYTDKAGNVFTKTFTLKRGGYAVNVGYSVQNASEKPLEVSTFGQLKQTAALPTSRdtqtgglSTMHT 217
Cdd:cd19961 77 ---EGGDSLTVTLTWTNGDGLTIEKTYTFDPDSYLIDVEVRVENNSSAPLSLSLYLQLQRKGGEPEGS-------GSTIT 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 218 FRGAAFsTSDTKYEKYKFDTILDNEnlNVSTKNGWVAMLQQYFTTAWVPQNNGTNNFYTANlGNGIVAIGYKSQPVLVQP 297
Cdd:cd19961 147 YEGPAG-TEDGKLEKLSFKDLEEEK--LSSGKVGWVAFKQKYFLSALIPDQGFFYSAKLSG-KDDGDGVKLLSAALTLPP 222
|
250 260 270
....*....|....*....|....*....|...
gi 1440323448 298 GQTDKLQSVLWVGPAIQDKMAAVAPHLDLTVDY 330
Cdd:cd19961 223 GGSGTFSFRLYAGPKDYDILKAYGPGLELAVDF 255
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
331-548 |
7.74e-52 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 189.24 E-value: 7.74e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 331 GWLWFISQP----LFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQ 406
Cdd:PRK01001 549 GFFSFITEPfaalLFIIMKFFKFLTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQM 628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 407 EMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFIL-WIHDLSAQD--------------PYYILPIIM 471
Cdd:PRK01001 629 EIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGASFIPgWIDNLTAPDvlfswetpiwfignEFHLLPILL 708
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 472 GATMFFIQKMSPTTVTDPM-----QQKIM-TFMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEKRGLHSR-- 543
Cdd:PRK01001 709 GVVMFAQQKISSLKRKGPVtdqqrQQEAMgTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWVTNKILDSKHLKNEvv 788
|
....*.
gi 1440323448 544 -EKKKS 548
Cdd:PRK01001 789 pNKKKH 794
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
345-539 |
1.25e-46 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 162.60 E-value: 1.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 345 KFIHSFLGNWGFS----IIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPL 420
Cdd:PRK00145 18 GFVSSVISNPNFSygiaIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 421 GGCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIHDLSAQDPYYILPIIMGATMFFIQKMspTTVTDPMQQKIMTFMPV 500
Cdd:PRK00145 98 GGCLPLLIQWPILIALYYVFNNLTGINGVSF-LWIKDLAKPDITWILPILSGATTYLSGYL--MTKADSSQAGQMKTMNI 174
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1440323448 501 IFTVFFLW----FPSGLVVYYIVSNLVTIIQQQLIYRGLEKRG 539
Cdd:PRK00145 175 GMSIFMGVmswkFKSALVLYWVIGNLIQIIQTYFIKKLELKKK 217
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
332-547 |
2.36e-42 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 152.23 E-value: 2.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 332 WLWFISQPLFKLLKFIHSFLG-NWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDD----KQRQSQ 406
Cdd:PRK02944 36 WNEYFVYPLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 407 EMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIhDLSAQDPYYILPIIMGATMFFIQK-MSPTT 485
Cdd:PRK02944 116 EMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSF-LWF-DLGQADPYYILPIVAGITTFIQQKlMMAGT 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1440323448 486 VTDPMQQKIMTF-MPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIyRGLEKRGLHSREKKK 547
Cdd:PRK02944 194 AGQNPQMAMMLWlMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI-KGPEIKASKAGGSKK 255
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
335-533 |
2.71e-42 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 154.13 E-value: 2.71e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 335 FISQPLF----KLLKFIHSFLG---------NWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDK 401
Cdd:PRK01315 10 AIMTPLYwvisGILVLFHTLLGflfgpdsglTWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYKGDR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 402 QRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVElRHAPFILWIHDL--SAQDPYY-------------- 465
Cdd:PRK01315 90 ERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAAS-RGDGIGPINPPLleSFRHAHIfgaplaatflqaln 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 466 -----------ILPIIMGATMFFIQK------MSPTTVTDPM--QQKIMTFM-PVIFTVFFLWFPSGLVVYYIVSNLVTI 525
Cdd:PRK01315 169 agntavqvvaaVLIILMSASQFITQLqlmtknMPPEAKTGPMaqQQKMLLYLfPLMFLVSGIAFPVGVLFYWLTSNVWTM 248
|
....*...
gi 1440323448 526 IQQQLIYR 533
Cdd:PRK01315 249 GQQFYVIR 256
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
318-537 |
5.46e-41 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 148.36 E-value: 5.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 318 AAVAPHLDLTVDYGWLWFISQPLFKLLKFIHSFL-GNWGFSIIVITFIVRGIMYPLTKAQYTSM----AKMRMLQPKIQA 392
Cdd:PRK01622 23 CSNAAPIDAHSDGFFDHYFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 393 MRERLGD----DKQRQSQ-EMMALYKAEKVNPLG-GCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIhDLSAQDpyYI 466
Cdd:PRK01622 103 IQAKLKVtkdlEKQKEYQkEMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSF-LWF-NLGHAD--HI 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1440323448 467 LPIIMGATMFFIQKMSPTTVTDPMQQ---KIMTFM-PVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLIYRGLEK 537
Cdd:PRK01622 179 LPIIAGLTYFIQMKVSQSNGTSPEQVqmlKIQGIMmPAMILFMSFAAPSALVLYWITGGLFLMGQTIVLRKVMER 253
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
58-329 |
1.59e-40 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 146.63 E-value: 1.59e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 58 KLITVKTDVLELTINTNGgDIEQALLLAYPKtlKSTEPFQLLETTPQfvyqAQSGLTGRDGPD--NPANGPRPLYSVDKE 135
Cdd:cd19960 1 IIATVKSKDFELTIDTLG-RISQFYLKDKKY--KNEDGKQLELISPQ----APKPLEIRFSDPalNEEAFKTPYTASVSE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 136 afvLADGQDEIVIPLTYTDKaGNVFTKTFTLKRGG-YAVNVGYSvqnasekpLEVSTFGQLKQTAALPTSrdtqtgglst 214
Cdd:cd19960 74 ---IDLESGPQSVVLTQTLS-GLTVTKTITFYPDGhYDVKVKLS--------KPVDYFITPGQRPNAAVD---------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 215 MHTFRGAAFSTSDTKYEKYKFDtilDNENLNVSTKNGWVAMLQQYFTTAWVPQNNGTNNFYTANlgngivaigyKSQPVL 294
Cdd:cd19960 132 SYTVHGALVKTADGTITIIEDG---DAEGTESFSNVNIAASFDRYYATLFYNFDKGLNVVVTKD----------ASDNPL 198
|
250 260 270
....*....|....*....|....*....|....*
gi 1440323448 295 VQPGQTDKLQSVLWVGPAIQDKMAAVAPHLDLTVD 329
Cdd:cd19960 199 VFVKGNGNFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
354-530 |
1.78e-40 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 145.36 E-value: 1.78e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 354 WGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERL------GDDKQRQ--SQEMMALYKAEKVNPLGGCFP 425
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQLEAAeaRKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 426 LIIQMPIFLALYYMLSASVELRHAPF----ILWIHDLSAQDPYYILPIIMGATMFFIQKMSPTTVTDPMQQ-----KIMT 496
Cdd:cd20069 84 PLVQAPVFISFFFALRKMANLPVPSFktggLLWFTDLTVPDPYYILPILTSLTFLATIELGAETGTSGSPQsktmkNVFR 163
|
170 180 190
....*....|....*....|....*....|....
gi 1440323448 497 FMPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQL 530
Cdd:cd20069 164 GLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLL 197
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
330-531 |
9.80e-28 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 113.29 E-value: 9.80e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 330 YGWLW-FISQPLFKLLKFIHSFLG-NWGFSIIVITFIVRGIMYPLT-----KAQYTSmAKMRMLQPKIQAMRERLG---- 398
Cdd:PRK02463 34 TGFIWnFLGAPMSYFIDYFANNLGlGFGLAIIIVTIIVRLIILPLGlyqswKATYQS-EKMAYLKPVFEPINERLKnatt 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 399 -DDKQRQSQEMMALYKAEKVNPLG--GCFPLIIQMPIFLALYYMLSASVELRHAPFiLWIhDLSAQDpyYILPIIMGATM 475
Cdd:PRK02463 113 qEEKMAAQTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTF-LGI-DLGSPS--LVLTAIIGVLY 188
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1440323448 476 FFIQKMSPTTVTDPMQQKIMTF---MPVIFTVFFLWFPSGLVVYYIVSNLVTIIQQQLI 531
Cdd:PRK02463 189 FFQSWLSMMGVPEEQREQMKAMmymMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLIT 247
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
333-537 |
3.48e-26 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 108.62 E-value: 3.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 333 LWFISQPLFKLLKFIHSFLG---------NWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQR 403
Cdd:PRK03449 2 LDFIYYPVSAILWFWHKLFSfvlgpdngfAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 404 QSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSA-------------SVE----------------------LRH 448
Cdd:PRK03449 82 MALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRSfnrtgtgfgqlgmSVEenrntpnyvfsaedvqsfldarLFG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 449 APFILWIHDLSAQDPYYI-------------LPIIMGATMFF-----IQKMSPTTVTDP---MQQKIMT-FMP--VIFTV 504
Cdd:PRK03449 162 APLSAYITMPRSGLDAFVdftrtniilvgvpLMIIAGVATHFnsrasVARQSAEAAANPqtaMMNKLALwVFPlgVLVGG 241
|
250 260 270
....*....|....*....|....*....|...
gi 1440323448 505 FFLwfPSGLVVYYIVSNLVTIIQQQLIYRGLEK 537
Cdd:PRK03449 242 PFL--PLAILLYWVSNNIWTFGQQHYVFGKIDK 272
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
335-499 |
3.87e-23 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 101.21 E-value: 3.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 335 FISQP-LFKLLKFIHSFLGNWGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQA----MRERLGDDKQRQSQEMM 409
Cdd:PRK02654 7 FISNNvMLPILDFFYGIVPSYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 410 ALYKaEKVNPLGGCFPLIIQMPIFLALYymlsasVELRHAPFILWIHDLSAQdpyyILP---IIMGATMFFIQKMSPTTV 486
Cdd:PRK02654 87 KLMK-EFGNPLAGCLPLLVQMPILFALF------ATLRGSPFADVNYTVNLQ----VLPseqIAAVQPQPFKSKPQNIFI 155
|
170
....*....|...
gi 1440323448 487 TDPMQQKIMTFMP 499
Cdd:PRK02654 156 TDGVHFPVIASLP 168
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
325-532 |
9.64e-18 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 84.68 E-value: 9.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 325 DLTVDYG-WLWFISQPLFKLLKFIHSFLGNWG-------FSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPK---IQAM 393
Cdd:PRK02201 96 SWTWKYGpFYGLFVYPIAQIILSIMASQSLSElygwstiLAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKkakIDAK 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 394 RERLGDD---KQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLSASVELRHApFILWIhDLSAQdPY------ 464
Cdd:PRK02201 176 YKDYKKDkqmKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVT-TWLGI-DLSAT-SWqeifag 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 465 ---YILPIIMGATMFFIQKMSPT----------TVTD------PMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTI 525
Cdd:PRK02201 253 nwiYLPILIIVVPVQALSQLLPQilnkkknkerTLNVkekealKKQNKTQNIISIVFIFFGVIFAAGVQIYWIIGGIWTI 332
|
....*..
gi 1440323448 526 IQQQLIY 532
Cdd:PRK02201 333 LQTLGIH 339
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
339-538 |
3.52e-15 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 77.58 E-value: 3.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 339 PLFKLLKFIHSFLGN---------WGFSIIVITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQS-QEM 408
Cdd:PRK00247 8 PVSGVMKLWHLLLHNvlglddslaWFASLFGLVITVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGKTDEASiREL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 409 MALYK-AEK---VNPLGGCFPLIIQMPIFLALYYML---SASVELRHAPFILWIHDLSAQD--------------PYY-- 465
Cdd:PRK00247 88 QQKQKdLNKeygYNPLAGCVPALIQIPVFLGLYQVLlrmARPEGGLENPVHQPIGFLTSEEvesflqgrvfnvplPAYvs 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440323448 466 -------------------ILPIIMGATMFFIQKMSPTTVTDPMQ-----------QKIMTFMPVIFTVFFLW------F 509
Cdd:PRK00247 168 mpaeqlaylgttqatvlafVLPLFIAAAVFTAINMAMSTYRSFQTndhdsgfavgmLKFLIVMAILAPIFPLSlgltgpF 247
|
250 260
....*....|....*....|....*....
gi 1440323448 510 PSGLVVYYIVSNLVTIIQQQLIYRGLEKR 538
Cdd:PRK00247 248 PTAIALYWVANNLWTLIQNIIMYLILERK 276
|
|
| |
