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Conserved domains on  [gi|1428230109|emb|SSO45815|]
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Uncharacterised protein [Acinetobacter baumannii]

Protein Classification

phage holin family protein( domain architecture ID 6603)

phage holin family protein may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis

Gene Ontology:  GO:0016020|GO:0005886
PubMed:  7669346

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phage_holin_2_1 super family cl04868
Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins ...
5-79 4.57e-10

Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis.


The actual alignment was detected with superfamily member pfam16082:

Pssm-ID: 446536  Cd Length: 76  Bit Score: 51.08  E-value: 4.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428230109  5 QSALEASAATlTSKVTATSGVGSFIGFAAKIDVIAWGGLLIAALGLAIQIYFALQKNRREKVEHEMRKAEYKLRI 79
Cdd:pfam16082  3 QETYEATAAA-GNKATYGGAGVSFAGFMLSNEFVALVGLAVALIGFLVNWYYKREANRRDQIEHEARLREEEDRC 76
 
Name Accession Description Interval E-value
Phage_holin_2_4 pfam16082
Bacteriophage holin family, superfamily II-like; Phage_holin_2_4 is a family of small ...
5-79 4.57e-10

Bacteriophage holin family, superfamily II-like; Phage_holin_2_4 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 406480  Cd Length: 76  Bit Score: 51.08  E-value: 4.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428230109  5 QSALEASAATlTSKVTATSGVGSFIGFAAKIDVIAWGGLLIAALGLAIQIYFALQKNRREKVEHEMRKAEYKLRI 79
Cdd:pfam16082  3 QETYEATAAA-GNKATYGGAGVSFAGFMLSNEFVALVGLAVALIGFLVNWYYKREANRRDQIEHEARLREEEDRC 76
PLN02316 PLN02316
synthase/transferase
53-80 5.77e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 34.08  E-value: 5.77e-03
                           10        20
                   ....*....|....*....|....*...
gi 1428230109   53 QIYFALQKNRREKVEHEMRKAEYKLRIK 80
Cdd:PLN02316   434 QIYRKLQEERRLREEAIRAKAEKTARMK 461
 
Name Accession Description Interval E-value
Phage_holin_2_4 pfam16082
Bacteriophage holin family, superfamily II-like; Phage_holin_2_4 is a family of small ...
5-79 4.57e-10

Bacteriophage holin family, superfamily II-like; Phage_holin_2_4 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.


Pssm-ID: 406480  Cd Length: 76  Bit Score: 51.08  E-value: 4.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428230109  5 QSALEASAATlTSKVTATSGVGSFIGFAAKIDVIAWGGLLIAALGLAIQIYFALQKNRREKVEHEMRKAEYKLRI 79
Cdd:pfam16082  3 QETYEATAAA-GNKATYGGAGVSFAGFMLSNEFVALVGLAVALIGFLVNWYYKREANRRDQIEHEARLREEEDRC 76
PLN02316 PLN02316
synthase/transferase
53-80 5.77e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 34.08  E-value: 5.77e-03
                           10        20
                   ....*....|....*....|....*...
gi 1428230109   53 QIYFALQKNRREKVEHEMRKAEYKLRIK 80
Cdd:PLN02316   434 QIYRKLQEERRLREEAIRAKAEKTARMK 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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