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Conserved domains on  [gi|1428479031|emb|SSO35528|]
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acetate kinase [Acinetobacter baumannii]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
25-408 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 583.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:COG0282     3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:COG0282    83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:COG0282   163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:COG0282   243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 408
Cdd:COG0282   323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
25-408 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 583.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:COG0282     3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:COG0282    83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:COG0282   163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:COG0282   243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 408
Cdd:COG0282   323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 25-408 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 568.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:PRK00180    3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 ---QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRY 173
Cdd:PRK00180   83 deiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 174 AIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRS 252
Cdd:PRK00180  163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKpLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 253 GDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL-P 331
Cdd:PRK00180  243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1428479031 332 SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 408
Cdd:PRK00180  323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 25-406 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 524.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELgvslde 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:cd24010    81 iDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKpLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQV 406
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 25-401 9.34e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 434.93  E-value: 9.34e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDlNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDS-GTGPQIWVIPTDEEGRIAK 401
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 25-403 1.42e-151

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 435.31  E-value: 1.42e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY--GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP----- 97
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 --QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFP--ELPQVAVFDTAFHQTMPAHAYR 172
Cdd:TIGR00016  86 eiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPlpKAKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 173 YAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTR 251
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 252 SGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP 331
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1428479031 332 -SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKET 403
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
25-408 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 583.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:COG0282     3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:COG0282    83 iDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:COG0282   163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKpLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:COG0282   243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 408
Cdd:COG0282   323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 25-408 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 568.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:PRK00180    3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 ---QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRY 173
Cdd:PRK00180   83 deiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 174 AIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRS 252
Cdd:PRK00180  163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKpLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 253 GDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL-P 331
Cdd:PRK00180  243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1428479031 332 SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQVVE 408
Cdd:PRK00180  323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 25-406 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 524.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELgvslde 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:cd24010    81 iDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:cd24010   161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKpLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:cd24010   241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKETRQV 406
Cdd:cd24010   321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREISTPDSKvKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 25-401 9.34e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 434.93  E-value: 9.34e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGD 254
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDlNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 255 VDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSID 334
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1428479031 335 GLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNnlKRGTEGRIDS-GTGPQIWVIPTDEEGRIAK 401
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 25-403 1.42e-151

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 435.31  E-value: 1.42e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRIY--GLAENLGAADARIKGITVGGEPLELSIPYADHAKALETLLARLANYKP----- 97
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 --QAIGHRVVHGGS-LTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFP--ELPQVAVFDTAFHQTMPAHAYR 172
Cdd:TIGR00016  86 eiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPlpKAKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 173 YAIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKFQKG-GWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTR 251
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 252 SGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP 331
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1428479031 332 -SIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGP-QIWVIPTDEEGRIAKET 403
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
PRK12379 PRK12379
propionate kinase;
25-400 1.05e-145

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 419.91  E-value: 1.05e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDR-IYGLAENLGAADARIkgiTV-GGEPLELSipYADHAKALETLLARLA----NYKPQ 98
Cdd:PRK12379    7 VLVINCGSSSIKFSVLDASDCEVlMSGIADGINSENAFL---SVnGGEPAPLA--HHSYEGALKAIAFELEkrnlNDSVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  99 AIGHRVVHGGSL-TKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAIPK 177
Cdd:PRK12379   82 LIGHRIAHGGSIfTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 178 FLYTEHNVRRYGFHGTSHAYVSDRGSELAG-KFQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGDVD 256
Cdd:PRK12379  162 EYYEELGVRRYGFHGTSHRYVSQRAHSLLNlDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 257 PSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSIDGL 336
Cdd:PRK12379  242 FGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDGI 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1428479031 337 IFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGTGPQIW-VIPTDEEGRIA 400
Cdd:PRK12379  322 IFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSRVICaVIPTNEEKMIA 386
PRK12440 PRK12440
acetate/propionate family kinase;
25-403 1.20e-123

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 363.80  E-value: 1.20e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALV-SERREDRIYGLAENLGAADARIkGITVGGEPLELSIPYAD--HAKALETLLARLANY----KP 97
Cdd:PRK12440    6 VLVINSGSSSLKFAVIdSVTGEAVLSGLGECFGLEDARM-SWKYQGEKTEIAIEGEDnhHKIAIGRLVGLTEELgftqDI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAIP 176
Cdd:PRK12440   85 VAVGHRIVHGGeKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAIA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 177 KFLYTEHNVRRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGDV 255
Cdd:PRK12440  165 KELYTDFGIRRYGFHGTSHYFVSREAAKMLNKpIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGDL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 256 DPSLHSFLAKNlGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLPSIDG 335
Cdd:PRK12440  245 DPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALDSLDG 323

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 336 LIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNLKRGTEGRIDSGT--GPQIWVIPTDEEGRIAKET 403
Cdd:PRK12440  324 IIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSEllNAVAMVIPTNEEFVIAQQS 393
PRK12397 PRK12397
acetate/propionate family kinase;
25-420 2.06e-114

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 340.66  E-value: 2.06e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  25 VLVINCGSSSIKYALVSERREDRI-YGLAENLGAADARIKgITVGGEPLELSIPYADHAKALETLLARLANYKP------ 97
Cdd:PRK12397    5 IMAINAGSSSLKFQLLEMPQGDMLcQGLIERIGMADAQVT-IKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIinslrd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 -QAIGHRVVHGGSLTK-AELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:PRK12397   84 iDGVGHRVAHGGEFFKdSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIYPL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYTEHNVRRYGFHGTSHAYVSdrgSELAGKFqkGGWLTA------HLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMG 249
Cdd:PRK12397  164 PWRYYAELGIRRYGFHGTSHKYVS---GVLAEKL--GVPLSAlrviccHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 250 TRSGDVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCG 329
Cdd:PRK12397  239 TRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQ 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 330 LPSIDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlkrgTEGRIDSGTGP-QIWVIPTDEEGRIAketRQVVE 408
Cdd:PRK12397  319 MGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR----NATFIQTENALvKVAVINTNEELMIA---QDVMR 391

                         410
                  ....*....|..
gi 1428479031 409 VSQNTSPEVSLA 420
Cdd:PRK12397  392 IALPATEGLCVP 403
PRK07157 PRK07157
acetate kinase; Provisional
 23-408 5.99e-114

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 339.41  E-value: 5.99e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  23 TSVLVINCGSSSIKYALVSERREDRIY-GLAENLGAADARIKgITVGGEPLELSIPYADHAKALETLLARLANYKP---- 97
Cdd:PRK07157    3 AKILVINAGSSSIKWQLFDKENLNLIAsGLAERIGLENGLIK-IKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLiedl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  98 ---QAIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRY 173
Cdd:PRK07157   82 eeiELIGFRVVHGGdYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYTY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 174 AIPKFLYTEHNVRRYGFHGTSHAYVSDRGSELAGKfQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSG 253
Cdd:PRK07157  162 PINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK-DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 254 DVDPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGL-PS 332
Cdd:PRK07157  241 DIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIgKK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 333 IDGLIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlKRGTEGRIDSGTGPQ----IWVIPTDEEGRIAKETRQVVE 408
Cdd:PRK07157  321 IDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLK-KIGEYGPIELISTPDsdipVYVIRTNEELLIAKNAIKLYE 399
PRK07058 PRK07058
acetate/propionate family kinase;
26-403 1.24e-86

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 269.23  E-value: 1.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  26 LVINCGSSSIKYAL--VSERREDRIYGLAENLGAADARIkGITVGGEPLELSI---PYADHAKALETLLARLANYKPQ-- 98
Cdd:PRK07058    7 LTFNAGSSTVKIGLfeVDGNEARRIGKGDIDFRRAPLRF-HLRNGGETLDIPLkasVTDDLHTVLDETFDWLAAHFDVse 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031  99 --AIGHRVVHGG-SLTKAELLTPEIVERIRAATPLAPLHNPAHLIGIEATMRLFPELPQVAVFDTAFHQTMPAHAYRYAI 175
Cdd:PRK07058   86 lvAVGHRVVHGGdRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLVRRFAI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 176 PKFLYtEHNVRRYGFHGTSHAYVSDRGSELAGKFQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLTPLEGVVMGTRSGDV 255
Cdd:PRK07058  166 PRALH-DEGIKRYGFHGLSYKFVAGELRRRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMATRCGAL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 256 DPSLHSFLAKNLGWDLAKIDKVLNNESGLLGLSQLSNDMRTVIeaaENGNEDACLAIEVFSYRLAKSLAALSCGLPSIDG 335
Cdd:PRK07058  245 DPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLL---ASDAPEAREALDLFALRIAGEIARLAATLGGLDA 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1428479031 336 LIFTGGIGENSAYIREKTLAYLPHFGLQLDKDQNNNlkrgTEGRIDSGTGP-QIWVIPTDEEGRIAKET 403
Cdd:PRK07058  322 VVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAA----NAFTISSRTSRvAAFVIPTDEEQVIADEA 386
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 186-352 1.38e-14

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 74.49  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 186 RRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLtPLEGVVMGTRSGDVDPSLHSFLA 264
Cdd:cd24011   147 RRSIFHALNQKAVARRAAKELGKpYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPVGDLIKLC 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 265 KNLGWDLAKIDKVLNNESGLLGLSQlSNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP-SIDGLIFTGGIG 343
Cdd:cd24011   226 FSGKYTLEELKKKLKGKGGLVAYLG-TNDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKgKVDAIILTGGLA 304


                  ....*....
gi 1428479031 344 eNSAYIREK 352
Cdd:cd24011   305 -YSKRLVDR 312
PRK03011 PRK03011
butyrate kinase; Provisional
 186-353 3.34e-10

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 61.33  E-value: 3.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 186 RRYGFHGTSHAYVSDRGSELAGK-FQKGGWLTAHLGNGSSTCAVWNGQSVDTSMGLtPLEGVVMGTRSGDVdPSLHsfLA 264
Cdd:PRK03011  149 RKSIFHALNQKAVARRVAKELGKkYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGL-PVGD--LV 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1428479031 265 KNL---GWDLAKIDKVLNNESGLLGLsqL-SNDMRTVIEAAENGNEDACLAIEVFSYRLAKSLAALSCGLP-SIDGLIFT 339
Cdd:PRK03011  225 ELCfsgKYTKEELKKKLVGKGGLVAY--LgTNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKgKVDAIVLT 302

                         170       180
                  ....*....|....*....|.
gi 1428479031 340 GGIgensAY-------IREKT 353
Cdd:PRK03011  303 GGL----AYskrlverIKERV 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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