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Conserved domains on  [gi|1315687706|emb|SNC57208|]
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Na(+)/dicarboxylate symporter [Vibrio cholerae]

Protein Classification

SLC13 family permease( domain architecture ID 12045581)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
101-462 3.93e-87

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 270.87  E-value: 3.93e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 101 LGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRSTYVF 180
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 181 VLLGVAYSASIGGIATLVGSPPNAIAAAE------VGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKP---TLNGTFELD 251
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPeikEVPGSKEVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 252 RAPVN----WDKGKVVTLGIFGLTVFLWIFSSPINAalggfksFDTLVALGAILMLSFARVVHWKEIQKTADWGVLLLFG 327
Cdd:COG0471   161 REELAelgpLSRREKIALAIFALTVLLWITGSLHGI-------PIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 328 GGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLI 407
Cdd:COG0471   234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAV 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1315687706 408 AVAASCAFMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFWQ 462
Cdd:COG0471   314 AFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
CitMHS pfam03600
Citrate transporter;
16-166 3.81e-06

Citrate transporter;


:

Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 48.85  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  16 WFLHRNSLIVLADVALFLALYHFLPFEHNVVLGISmlAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANS 95
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAIS--ALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWS 255

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1315687706  96 IIFLFLGGFALAAAMHHQGLDKVIADkvLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVL 166
Cdd:pfam03600 256 TLLFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
101-462 3.93e-87

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 270.87  E-value: 3.93e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 101 LGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRSTYVF 180
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 181 VLLGVAYSASIGGIATLVGSPPNAIAAAE------VGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKP---TLNGTFELD 251
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPeikEVPGSKEVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 252 RAPVN----WDKGKVVTLGIFGLTVFLWIFSSPINAalggfksFDTLVALGAILMLSFARVVHWKEIQKTADWGVLLLFG 327
Cdd:COG0471   161 REELAelgpLSRREKIALAIFALTVLLWITGSLHGI-------PIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 328 GGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLI 407
Cdd:COG0471   234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAV 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1315687706 408 AVAASCAFMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFWQ 462
Cdd:COG0471   314 AFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-461 1.19e-85

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 269.60  E-value: 1.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  41 FEHNVVLGISMLAFIAVLWLTEALHVTVTAIL-VPVMAVFFGI---FETQAALNNFANSIIFLFLGGFALAAAMHHQGLD 116
Cdd:TIGR00785   6 LNSGAWLLLAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVlsaFKFKNALSGFADPTIWLFFGAFILATALVKTGLG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 117 KVIADKVLA-MAQGKMSVAVFMLFGVTALLSMWISNTA-TAAMMLPLVLGVLSKVDADKQ---RSTYVFVLLGVAYSASI 191
Cdd:TIGR00785  86 KRIAYKLVGkMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPEkspRKIGKYLMLGIAYSASI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 192 GGIATLVGSPPNAIAAAEVG------LSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRapvnWDKGKV--- 262
Cdd:TIGR00785 166 GSSGFLTGSAPNALAAGILSkilgiqISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVDL----WAKEELeem 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 263 --------VTLGIFGLTVFLWIFSSpinaaLGGFKsfDTLVALGAILMLSFARVVHWKEIQK-TADWGVLLLFGGGLCLS 333
Cdd:TIGR00785 242 gpmsfrekALLGIFLLALLLWIFGG-----SLGIN--ASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLA 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 334 NVLKQTGTSVFLANALSDMVSHMGIFVVILV-VATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAAS 412
Cdd:TIGR00785 315 GGLKKSGFIKWFSEKLVGILDGLSPTIAVLVlVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAS 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1315687706 413 CA-FMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFW 461
Cdd:TIGR00785 395 LMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 49-461 2.48e-78

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 248.65  E-value: 2.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  49 ISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQ 128
Cdd:cd01115     1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 129 GKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRstyvfVLLGVAYSASIGGIATLVGSPPNAIAAA 208
Cdd:cd01115    81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR-----LLMPLAFAASIGGMLTLIGTPPNLVASG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 209 EVGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKptlngtfeldrapvnwdkgkvVTLGIFGLTVFLWIFSspinAALGGF 288
Cdd:cd01115   156 YLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFI---------------------FRLAVLIITIVLLAAL----AAITGL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 289 KSFDTLVALGAILMLsFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATF 368
Cdd:cd01115   211 LPVSVAIAIGAIVLV-FGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLLLCLL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 369 VVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAASCAFMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIA 448
Cdd:cd01115   290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369

                         410
                  ....*....|...
gi 1315687706 449 CIGLLTAIAMLFW 461
Cdd:cd01115   370 SLVVSVTMIPLIW 382
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 52-461 1.76e-33

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 131.73  E-value: 1.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  52 LAFIAVLWLTEALHVTVTAI----LVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMA 127
Cdd:pfam00939  37 FIATIVGWILEPLPMAVIALfaisLSAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKM 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 128 QGKMSVAVFMLfgVTALLSMWISNTATAAMMLPLVLGVL--------SKVDADKQRSTYVFVLLGVAYSASIGGIATLVG 199
Cdd:pfam00939 117 GKRTLGLGYGL--VFSDLLLAPATPSNTARAGGIVFPIImslppafgSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 200 SPPNAIAAAEVG------LSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRA---------PVNwdKGKVVT 264
Cdd:pfam00939 195 MAPNLLLLGLMNsilgvtITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVPDAKAIaktelkelgPMT--FREKAL 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 265 LGIFGLTVFLWIFSSPINAAlggfksfDTLVALGAILMLSFARVVHWKEI-QKTADWGVLLLFGGGLCLSNVLKQTGTSV 343
Cdd:pfam00939 273 LGLFVLLLLLWIFGGSLNID-------ATTVAIIGLALMLLLRILDWKDIvKNKGAWNTLIWLGGLIMLANGLERSGFIE 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 344 FLANALSDMVSHM-GIFVVILVVATFVVFLTEFASNTASAALLIPVFATVAEAF-GMSPVLLSVLIAVAASCA-FMLPVA 420
Cdd:pfam00939 346 WLGNTLSTSLSGFsPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYG 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1315687706 421 TPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFW 461
Cdd:pfam00939 426 TGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWW 466
CitMHS pfam03600
Citrate transporter;
16-166 3.81e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 48.85  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  16 WFLHRNSLIVLADVALFLALYHFLPFEHNVVLGISmlAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANS 95
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAIS--ALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWS 255

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1315687706  96 IIFLFLGGFALAAAMHHQGLDKVIADkvLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVL 166
Cdd:pfam03600 256 TLLFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
101-462 3.93e-87

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 270.87  E-value: 3.93e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 101 LGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRSTYVF 180
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 181 VLLGVAYSASIGGIATLVGSPPNAIAAAE------VGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKP---TLNGTFELD 251
Cdd:COG0471    81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPeikEVPGSKEVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 252 RAPVN----WDKGKVVTLGIFGLTVFLWIFSSPINAalggfksFDTLVALGAILMLSFARVVHWKEIQKTADWGVLLLFG 327
Cdd:COG0471   161 REELAelgpLSRREKIALAIFALTVLLWITGSLHGI-------PIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 328 GGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLI 407
Cdd:COG0471   234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAV 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1315687706 408 AVAASCAFMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFWQ 462
Cdd:COG0471   314 AFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-461 1.19e-85

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 269.60  E-value: 1.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  41 FEHNVVLGISMLAFIAVLWLTEALHVTVTAIL-VPVMAVFFGI---FETQAALNNFANSIIFLFLGGFALAAAMHHQGLD 116
Cdd:TIGR00785   6 LNSGAWLLLAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVlsaFKFKNALSGFADPTIWLFFGAFILATALVKTGLG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 117 KVIADKVLA-MAQGKMSVAVFMLFGVTALLSMWISNTA-TAAMMLPLVLGVLSKVDADKQ---RSTYVFVLLGVAYSASI 191
Cdd:TIGR00785  86 KRIAYKLVGkMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPEkspRKIGKYLMLGIAYSASI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 192 GGIATLVGSPPNAIAAAEVG------LSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRapvnWDKGKV--- 262
Cdd:TIGR00785 166 GSSGFLTGSAPNALAAGILSkilgiqISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVDL----WAKEELeem 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 263 --------VTLGIFGLTVFLWIFSSpinaaLGGFKsfDTLVALGAILMLSFARVVHWKEIQK-TADWGVLLLFGGGLCLS 333
Cdd:TIGR00785 242 gpmsfrekALLGIFLLALLLWIFGG-----SLGIN--ASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLA 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 334 NVLKQTGTSVFLANALSDMVSHMGIFVVILV-VATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAAS 412
Cdd:TIGR00785 315 GGLKKSGFIKWFSEKLVGILDGLSPTIAVLVlVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAS 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1315687706 413 CA-FMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFW 461
Cdd:TIGR00785 395 LMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 49-461 2.48e-78

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 248.65  E-value: 2.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  49 ISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQ 128
Cdd:cd01115     1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 129 GKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRstyvfVLLGVAYSASIGGIATLVGSPPNAIAAA 208
Cdd:cd01115    81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR-----LLMPLAFAASIGGMLTLIGTPPNLVASG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 209 EVGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKptlngtfeldrapvnwdkgkvVTLGIFGLTVFLWIFSspinAALGGF 288
Cdd:cd01115   156 YLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFI---------------------FRLAVLIITIVLLAAL----AAITGL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 289 KSFDTLVALGAILMLsFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATF 368
Cdd:cd01115   211 LPVSVAIAIGAIVLV-FGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLLLCLL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 369 VVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAASCAFMLPVATPPNAIVFASGHIKQSEMMRVGLYLNIA 448
Cdd:cd01115   290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369

                         410
                  ....*....|...
gi 1315687706 449 CIGLLTAIAMLFW 461
Cdd:cd01115   370 SLVVSVTMIPLIW 382
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 56-456 2.45e-46

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 165.12  E-value: 2.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  56 AVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVaV 135
Cdd:cd00625     1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRL-L 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 136 FMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKqrstYVFVLLGVAYSASIGGIATLVGSPPNAIAAAEVGLSFT 215
Cdd:cd00625    80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP----PVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 216 DWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFE--------LDRAPVNWDKGKVVTLGIFGLTVFLWIFSSPINAALGg 287
Cdd:cd00625   156 DFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEdkltvlaePLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIAL- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 288 fksfdtlvALGAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHmGIFVVILVVAT 367
Cdd:cd00625   235 --------LGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGL-PPLAALLLIGL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 368 FVVFLTEFASNTASAALLIPVFATVAEAF-----GMSPVLLSVLIAVAASCAFMLPVATPPNAIVfasgHIKQSEMMRVG 442
Cdd:cd00625   306 LSALLSNFISNVPTVALLLPIAASLAPPEpawlaLALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVG 381

                         410
                  ....*....|....
gi 1315687706 443 LYLNIACIGLLTAI 456
Cdd:cd00625   382 LPLTLLSLVVSLLY 395
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 52-461 1.76e-33

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 131.73  E-value: 1.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  52 LAFIAVLWLTEALHVTVTAI----LVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMA 127
Cdd:pfam00939  37 FIATIVGWILEPLPMAVIALfaisLSAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKM 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 128 QGKMSVAVFMLfgVTALLSMWISNTATAAMMLPLVLGVL--------SKVDADKQRSTYVFVLLGVAYSASIGGIATLVG 199
Cdd:pfam00939 117 GKRTLGLGYGL--VFSDLLLAPATPSNTARAGGIVFPIImslppafgSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 200 SPPNAIAAAEVG------LSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRA---------PVNwdKGKVVT 264
Cdd:pfam00939 195 MAPNLLLLGLMNsilgvtITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVPDAKAIaktelkelgPMT--FREKAL 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 265 LGIFGLTVFLWIFSSPINAAlggfksfDTLVALGAILMLSFARVVHWKEI-QKTADWGVLLLFGGGLCLSNVLKQTGTSV 343
Cdd:pfam00939 273 LGLFVLLLLLWIFGGSLNID-------ATTVAIIGLALMLLLRILDWKDIvKNKGAWNTLIWLGGLIMLANGLERSGFIE 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 344 FLANALSDMVSHM-GIFVVILVVATFVVFLTEFASNTASAALLIPVFATVAEAF-GMSPVLLSVLIAVAASCA-FMLPVA 420
Cdd:pfam00939 346 WLGNTLSTSLSGFsPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYG 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1315687706 421 TPPNAIVFASGHIKQSEMMRVGLYLNIACIGLLTAIAMLFW 461
Cdd:pfam00939 426 TGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWW 466
CitMHS pfam03600
Citrate transporter;
56-411 4.80e-32

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 125.12  E-value: 4.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  56 AVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAV 135
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 136 FMLFGVTALLSMWISNTATAAMMLPLVLGVlskvdADKQRSTYVFVLLGVAYSASIGGIATLVGSPPNAIAAAEVGLSFT 215
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLAL-----ARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 216 D-----WMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRAPVNWDKGKVVtLGIFGLTVFLWIFSSPINAalggfks 290
Cdd:pfam03600 156 DfgffmFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLL-LAISALVLALVILGFLLLS------- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 291 fdtLVALGAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSdmvSHMGIFVVILVVATFVV 370
Cdd:pfam03600 228 ---VLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALG---GLSGLLVALALILWLSA 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1315687706 371 FLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAA 411
Cdd:pfam03600 302 LLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLAWALAVG 342
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
45-409 1.63e-23

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 102.13  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  45 VVLGISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVL 124
Cdd:COG1055     4 LALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 125 AMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADkqrstYVFVLLGVAYSASIGGIATLVGSPPNA 204
Cdd:COG1055    84 RRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN-----PVPFLIAIVFAANIGGAATPIGNPTNI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 205 IAAAEVGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRAPVNWDKGK---VVTLGIFGLTVFLWIFSSPI 281
Cdd:COG1055   159 MIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDPKEAIKDRrllRISLLVLALLLVGFVLHSFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 282 NAALGgfksfdtLVALGAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHmGIFVV 361
Cdd:COG1055   239 GLPPA-------LIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG-NLLLA 310

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1315687706 362 ILVVATFVVFLTEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAV 409
Cdd:COG1055   311 ALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLALALGA 358
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 61-400 9.19e-20

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 91.16  E-value: 9.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  61 TEALHVTVTAILVPVMAVFFGIFETQAALNNFANSI----IFLFLGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVF 136
Cdd:cd01116    10 FEKVHRTVAALAGALWLVILGLATLSPDLETIVSWVdwetLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 137 MLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKqrstyVFVLLGVAYSASIGGIATLVGSPPNAIAAAEVGLSFTD 216
Cdd:cd01116    90 LLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNP-----VPVLISEVIAANIGGAATLIGDPPNIMIGSAAGLTFND 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 217 WMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRAPVNWDKGK--------VVTLGIFGLTVFLWIFSSPINAALGgf 288
Cdd:cd01116   165 FLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALAELEPKYpikdkvllLKSLTILTLVIIGFVLHSPLGVSLG-- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 289 ksfdtLVAL-GAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALsDMVSHMGIFVVILVVAT 367
Cdd:cd01116   243 -----WIALlGALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELL-VGVILGRIAVAVILILW 316

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1315687706 368 FVVFLTEFASNTASAALLIPVFATVAEAFGMSP 400
Cdd:cd01116   317 ISALLSAFIDNIPVTATMIPIVKDLASQLGIPL 349
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
52-241 4.75e-19

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 88.29  E-value: 4.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  52 LAFIAVLWLTEALH---VTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQ 128
Cdd:COG0471   181 FALTVLLWITGSLHgipIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLG 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 129 GK-MSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADkqrstYVFVLLGVAYSASiGGIATLVGSPPNAIAA 207
Cdd:COG0471   261 GLsPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVN-----PLPLALAVAFAAS-CAFLLPVGTPPNAIVY 334

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1315687706 208 AEVGLSFTDWMKFGLPTAMMMLPMAIAILYFLLK 241
Cdd:COG0471   335 GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 45-239 1.63e-14

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 74.93  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  45 VVLGISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVL 124
Cdd:cd01115   192 AVLIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALI 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 125 AMAQGKMSVAVFMLFG-VTALLSMWISNTATAAMMLPLVLGVLSKVDADKqrstyVFVLLGVAYSASIgGIATLVGSPPN 203
Cdd:cd01115   272 SLLGGLPPFAILLLLClLTLVLTNFISNTATAVLLAPIALSIALSLGLPP-----EALLLAVAIGASC-AFMLPVGTPPN 345

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1315687706 204 AIAAAEVGLSFTDWMKFGLP-TAMMMLPMAIAILYFL 239
Cdd:cd01115   346 AIVLGPGGYKFSDFAKVGLPlSILSLVVSVTMIPLIW 382
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 45-239 1.46e-10

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 62.65  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  45 VVLGISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIfETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVL 124
Cdd:cd00625   211 LALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGL-DPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLV 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 125 AMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDAdkqrstyvfvLLGVAYSASIGGIATLVGSPPNA 204
Cdd:cd00625   290 ALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPEPA----------WLALALGSTLGGNLTLIGSLANL 359

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1315687706 205 IAA-----AEVGLSFTDWMKFGLPtamMMLPMAIAILYFL 239
Cdd:cd00625   360 IPLgaaenAGVGISFGEFLKVGLP---LTLLSLVVSLLYL 396
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
51-240 1.06e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 57.06  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  51 MLAFIAVLWLTEALHVTVTAILVPVMAV--FFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQ 128
Cdd:COG1055   225 LALLLVGFVLHSFLGLPPALIALLGAAVllLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTG 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 129 GKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQrstyvfvLLGVAYSASIGGIATLVGSPPNAIAA- 207
Cdd:COG1055   305 GNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPL-------WLALALGATLGGNLTPIGSAANVIVLg 377

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1315687706 208 ----AEVGLSFTDWMKFGLPtaMMMLPMAIAILYFLL 240
Cdd:COG1055   378 iaekKGIKISFGEFLKVGLP--LTLLTLLIALLYLLL 412
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 22-239 4.68e-08

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 54.95  E-value: 4.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  22 SLIVLADVALFLALYHFLPFEhnvvlgISMLAFIAVLWLtealhvtvtailvpvmAVFFGIFETQAALNNFANSIIFLFL 101
Cdd:cd01116   220 SLTILTLVIIGFVLHSPLGVS------LGWIALLGALLL----------------LLLADKLDFEDVLSRVEWDTLLFFA 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 102 GGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQRstyvfV 181
Cdd:cd01116   278 GLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLP-----L 352

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1315687706 182 LLGVAYSASIGGIATLVGSPPNAIAA-----AEVGLSFTDWMKFGLPtaMMMLPMAIAILYFL 239
Cdd:cd01116   353 WWALALGACLGGNGTLIGASANVVAAgiaeqHGYKISFWEFLKVGFP--IMLVSLILATVYLL 413
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 67-274 1.09e-06

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 50.74  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  67 TVTAILVPVMAVFFGIFETQAALNNFANSIIFLFLGGFALAAAMHHQGLDKVIADKVLAMAQGKMSVAVFMLFgVTALLS 146
Cdd:cd01117    14 WAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLVL-LSGILS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 147 MWISNTATAAMMLPLVLGVlskvdADKQRSTYVFVLLGVAYSASIGGIATLVGSPPNAIAAAEVGLSFTDWMKFGLPTAM 226
Cdd:cd01117    93 ALLTNDTACLVFTPIVLEL-----ARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASESGISFPFFLAAMAPLAL 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1315687706 227 MMLPMAIAILYFL-------LKPTLNGTFELDRAPVNWDKGKVVTLGIFGLTVFL 274
Cdd:cd01117   168 LGLLLLLILLLVLfpgelkgLPLDKATKEEGVGARKLAVKLLVLILLLLVAFLAL 222
CitMHS pfam03600
Citrate transporter;
16-166 3.81e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 48.85  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  16 WFLHRNSLIVLADVALFLALYHFLPFEHNVVLGISmlAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFANS 95
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAIS--ALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWS 255

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1315687706  96 IIFLFLGGFALAAAMHHQGLDKVIADkvLAMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVL 166
Cdd:pfam03600 256 TLLFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 47-409 1.99e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 40.33  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706  47 LGISMLAFIAVLWLTEALHVTVTAILVPVMAVFFGIFETQAALNNFA--NSIIFLFLGGFALAAAMHHQGLDKVIADKVL 124
Cdd:cd01118     3 IAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEWVAALAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 125 AMAQGKMSVAVFMLFGVTALLSMWISNTATAAMMLPLVLGVLSKVDADKQR-STYVFVLLGVAYSASiggIATLVGSPPN 203
Cdd:cd01118    83 RWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRtLPFLYACAFIADAAS---LPLPISNLVN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 204 AIAAAEVGLSFTDWMKFGLPTAMMMLPMAIAILYFLLKPTLNGTFELDRAPVNWDKGKVVTLGIFGLTVF-LWIFSSPIN 282
Cdd:cd01118   160 IVTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLvLLVVSAFGV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 283 AALGGFKSFDTLV-ALGAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHmGIFVV 361
Cdd:cd01118   240 DILLIPPSFIAGVlALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQ-GLLAA 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1315687706 362 ILVVATFVVFLTEFASNTASAALLIPvfaTVAEAFGMSPVLLSVLIAV 409
Cdd:cd01118   319 ILGVGLLAAFLSNVMNNLPAVLIGAL---ALAAGHAPEALVYANLIGV 363
CitMHS pfam03600
Citrate transporter;
293-461 3.22e-03

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 39.60  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 293 TLVALGAILMLSFARVVHWKEIQKTADWGVLLLFGGGLCLSNVLKQTGTSVFLANALSDMVSHMGIFVVILVVATfVVFL 372
Cdd:pfam03600  12 DVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLA-TALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315687706 373 TEFASNTASAALLIPVFATVAEAFGMSPVLLSVLIAVAASCAFML-PVATPPNAIVFASGHIKQSEMMRVGLYLNIACIG 451
Cdd:pfam03600  91 SAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALL 170

                         170
                  ....*....|
gi 1315687706 452 LLTAIAMLFW 461
Cdd:pfam03600 171 LVGLLPLLLI 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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