|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
61-402 |
8.64e-162 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 460.77 E-value: 8.64e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrTAEPRRPLAVVLAPT 140
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD--PSRPRAPQALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE- 299
Cdd:COG0513 161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEd 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 -GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPT 378
Cdd:COG0513 241 pERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
|
330 340
....*....|....*....|....
gi 1110512917 379 DHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0513 321 DPEDYVHRIGRTGRAGAEGTAISL 344
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
57-402 |
2.80e-90 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 279.76 E-value: 2.80e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 57 PAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVV 136
Cdd:PRK11776 1 MSMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLD---VKRFRVQALV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEAD 215
Cdd:PRK11776 78 LCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDlSEGAVSTMEHHVVHVSPAEK-KAVATR 294
Cdd:PRK11776 158 RMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVE-STHDLPAIEQRFYEVSPDERlPALQRL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 295 IA-AREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PRK11776 237 LLhHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVIN 316
|
330 340
....*....|....*....|....*....
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK11776 317 YELARDPEVHVHRIGRTGRAGSKGLALSL 345
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
71-262 |
6.35e-84 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 254.29 E-value: 6.35e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMD-GRTAEPRRPLAVVLAPTRELAQQVAD 149
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLpEPKKKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
|
170 180 190
....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd00268 161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPV 193
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
60-397 |
5.63e-78 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 250.46 E-value: 5.63e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRR-----PLA 134
Cdd:PTZ00110 130 VSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAF---LLPAIVHINAQPLLrygdgPIV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 135 VVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEA 214
Cdd:PTZ00110 207 LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEA 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 215 DQMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVH----SVDLSegAVSTMEHHVVHVSPAEKKA 290
Cdd:PTZ00110 287 DRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEEPVHvnvgSLDLT--ACHNIKQEVFVVEEHEKRG 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 291 ----VATRIAAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVD 366
Cdd:PTZ00110 365 klkmLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVK 444
|
330 340 350
....*....|....*....|....*....|.
gi 1110512917 367 GLDLVVNIDPPTDHKDYLHRGGRTARAGESG 397
Cdd:PTZ00110 445 DVKYVINFDFPNQIEDYVHRIGRTGRAGAKG 475
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
42-397 |
6.90e-78 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 248.29 E-value: 6.90e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 42 PSGEFALPVTVTPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG 121
Cdd:PRK01297 69 PASLWKLEDFVVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 122 MDGRTAEPRR----PLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLR-QGVHLVVATPGRLRDLM 196
Cdd:PRK01297 149 LLQTPPPKERymgePRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFN 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 197 ERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVS 274
Cdd:PRK01297 229 QRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEERqtLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASD 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 275 TMEHHVVHVSPAEKKAVATRIAAREG--RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTA 352
Cdd:PRK01297 309 TVEQHVYAVAGSDKYKLLYNLVTQNPweRVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRV 388
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1110512917 353 LIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESG 397
Cdd:PRK01297 389 LVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASG 433
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
62-402 |
4.14e-74 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 237.53 E-value: 4.14e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGL-ALLAGMDGRTAEPRRPLAVVLAPT 140
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLpALQHLLDFPRRKSGPPRILILTPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLM--ERGDCvlDRVESAVLDEADQMT 218
Cdd:PRK11192 83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIkeENFDC--RAVETLILDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 219 DMGFMPQVTAILQEvpAGGRR--MLFSATLD-RNVDTLVRRFLNDPVVHSVDLS--EGAV--------STMEHhvvhvsp 285
Cdd:PRK11192 161 DMGFAQDIETIAAE--TRWRKqtLLFSATLEgDAVQDFAERLLNDPVEVEAEPSrrERKKihqwyyraDDLEH------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 286 aeKKAVATRIAARE--GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGI 363
Cdd:PRK11192 232 --KTALLCHLLKQPevTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGI 309
|
330 340 350
....*....|....*....|....*....|....*....
gi 1110512917 364 HVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK11192 310 DIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
61-402 |
1.34e-73 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 236.63 E-value: 1.34e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEP--RRPL-AVVL 137
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAkgRRPVrALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAA 297
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLSQMIG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REG--RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNID 375
Cdd:PRK10590 242 KGNwqQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYE 321
|
330 340
....*....|....*....|....*..
gi 1110512917 376 PPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK10590 322 LPNVPEDYVHRIGRTGRAAATGEALSL 348
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
61-397 |
1.79e-71 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 235.90 E-value: 1.79e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPT 140
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLD---PELKAPQILVLAPT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTD 219
Cdd:PRK11634 84 RELAVQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE 299
Cdd:PRK11634 164 MGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 --GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPP 377
Cdd:PRK11634 244 dfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIP 323
|
330 340
....*....|....*....|
gi 1110512917 378 TDHKDYLHRGGRTARAGESG 397
Cdd:PRK11634 324 MDSESYVHRIGRTGRAGRAG 343
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
61-402 |
2.19e-68 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 226.37 E-value: 2.19e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTA----EPRRPLAVV 136
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPAladrKPEDPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEAD 215
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVsLHACEICVLDEAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVAT 293
Cdd:PRK04537 170 RMFDLGFIKDIRFLLRRMPERGTRqtLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 294 RIAAR-EG-RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLV 371
Cdd:PRK04537 250 GLLSRsEGaRTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYV 329
|
330 340 350
....*....|....*....|....*....|.
gi 1110512917 372 VNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK04537 330 YNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
62-402 |
5.77e-67 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 218.30 E-value: 5.77e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLA----LLAGMDGRTAEPRRPLAVVL 137
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTAtfhyLLSHPAPEDRKVNQPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRI 295
Cdd:PRK04837 170 FDLGFIKDIRWLFRRMPPANQRlnMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLLQTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 296 AARE--GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PRK04837 250 IEEEwpDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFN 329
|
330 340
....*....|....*....|....*....
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK04837 330 YDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
61-260 |
5.69e-61 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 196.55 E-value: 5.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM----------DGRTAEPR 130
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgppsvgrGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 131 rplAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAV 210
Cdd:cd17967 81 ---ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLV 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 211 LDEADQMTDMGFMPQVTAILQE---VPAGGRR-MLFSATLDRNVDTLVRRFLND 260
Cdd:cd17967 158 LDEADRMLDMGFEPQIRKIVEHpdmPPKGERQtLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
62-265 |
8.20e-58 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 187.82 E-value: 8.20e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrTAEPRRPLAVVLAPTR 141
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL---SEDPYGIFALVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGD---CVLDRVESAVLDEADQMT 218
Cdd:cd17955 78 ELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDdttKVLSRVKFLVLDEADRLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHS 265
Cdd:cd17955 158 TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
61-400 |
1.83e-57 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 196.16 E-value: 1.83e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG----MDGRTAEPRRPLAVV 136
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRcctiRSGHPSEQRNPLAMV 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQ 216
Cdd:PLN00206 202 LTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDC 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 217 MTDMGFMPQVTAILQEVPAgGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIA 296
Cdd:PLN00206 282 MLERGFRDQVMQIFQALSQ-PQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDIL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 297 AREGR----VIMFLDTKRAVDRMAEHL-LASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLV 371
Cdd:PLN00206 361 KSKQHfkppAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQV 440
|
330 340
....*....|....*....|....*....
gi 1110512917 372 VNIDPPTDHKDYLHRGGRTARAGESGNVV 400
Cdd:PLN00206 441 IIFDMPNTIKEYIHQIGRASRMGEKGTAI 469
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
58-401 |
1.83e-57 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 193.12 E-value: 1.83e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 58 AAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVL 137
Cdd:PTZ00424 26 IVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ---ALIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PTZ00424 103 APTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEM 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKaVATRIAA 297
Cdd:PTZ00424 183 LSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWK-FDTLCDL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REG----RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PTZ00424 262 YETltitQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVIN 341
|
330 340 350
....*....|....*....|....*....|.
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESG---NVVT 401
Cdd:PTZ00424 342 YDLPASPENYIHRIGRSGRFGRKGvaiNFVT 372
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
71-263 |
3.53e-57 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 186.76 E-value: 3.53e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR-----PLAVVLAPTRELAQ 145
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEEtkddgPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 146 QVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQ 225
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 226 VTAILQEVP----------------AGGRR----MLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17945 161 VTKILDAMPvsnkkpdteeaeklaaSGKHRyrqtMMFTATMPPAVEKIAKGYLRRPVV 218
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
61-262 |
7.72e-57 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 185.21 E-value: 7.72e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrTAEPRRPLAVVLAPT 140
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL---LENPQRFFALVLAPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEADQMTD 219
Cdd:cd17954 78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFsLKSLKFLVMDEADRLLN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17954 158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPV 200
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
75-262 |
2.80e-55 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 181.03 E-value: 2.80e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRR-----PLAVVLAPTRELAQQVAD 149
Cdd:cd17966 5 LKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAF---LLPAIVHINAQPPLergdgPIVLVLAPTRELAQQIQQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17966 82 EANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRKI 161
|
170 180 190
....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17966 162 VDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
61-262 |
3.24e-53 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 176.41 E-value: 3.24e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR-PLAVVLA 138
Cdd:cd17953 13 KWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHiKDQRPVKPGEgPIGLIMA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGD---CVLDRVESAVLDEAD 215
Cdd:cd17953 93 PTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrvTNLRRVTYVVLDEAD 172
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17953 173 RMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
75-263 |
4.33e-53 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 175.30 E-value: 4.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR-PLAVVLAPTRELAQQVADSLE 152
Cdd:cd17952 5 IRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHiMDQRELEKGEgPIAVIVAPTRELAQQIYLEAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 153 PYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE 232
Cdd:cd17952 85 KFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGH 164
|
170 180 190
....*....|....*....|....*....|.
gi 1110512917 233 VPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17952 165 VRPDRQTLLFSATFKKKIEQLARDILSDPIR 195
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
71-262 |
1.20e-52 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 173.98 E-value: 1.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17947 81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFdLDSIEILVLDEADRMLEEGFADELKEI 160
|
170 180 190
....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17947 161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-253 |
1.91e-52 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 172.43 E-value: 1.91e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 84 SEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPTRELAQQVADSLEPYARSVGVRTA 163
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQ---ALVLAPTRELAEQIYEELKKLGKGLGLKVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 164 TVVGGMPIHRQARSLRqGVHLVVATPGRLRDLMERGDcVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRRMLFS 243
Cdd:pfam00270 78 SLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLS 155
|
170
....*....|
gi 1110512917 244 ATLDRNVDTL 253
Cdd:pfam00270 156 ATLPRNLEDL 165
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
71-259 |
3.37e-50 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 168.96 E-value: 3.37e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLA-GRDVLGRSRTGSGKTLAFGLALLAGM------DGRTAEPRRPLAVVLAPTREL 143
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLlsqkssNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 144 AQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESA---VLDEADQMTDM 220
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLKSLrflVLDEADRMLEK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1110512917 221 GFMPQVTAIL---QEVPAGGRR----MLFSATLDRNVDTLVRRFLN 259
Cdd:cd17946 161 GHFAELEKILellNKDRAGKKRkrqtFVFSATLTLDHQLPLKLNSK 206
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
47-259 |
6.74e-49 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 166.68 E-value: 6.74e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 47 ALPVTVT----PalPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM 122
Cdd:cd18052 28 EIPVEVTgrnpP--PAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 123 --DGRTA----EPRRPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLM 196
Cdd:cd18052 106 mkEGLTAssfsEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFI 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1110512917 197 ERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE--VPAGGRR--MLFSATLDRNVDTLVRRFLN 259
Cdd:cd18052 186 GRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEpgMPSKEDRqtLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
60-260 |
1.51e-48 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 165.21 E-value: 1.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM------DGRTAEPRR-- 131
Cdd:cd18051 21 ETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgpgESLPSESGYyg 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 132 -----PLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRV 206
Cdd:cd18051 101 rrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLDYC 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 207 ESAVLDEADQMTDMGFMPQVTAILQE---VPAGGRRML-FSATLDRNVDTLVRRFLND 260
Cdd:cd18051 181 KYLVLDEADRMLDMGFEPQIRRIVEQdtmPPTGERQTLmFSATFPKEIQMLARDFLDN 238
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
277-402 |
1.75e-46 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 155.74 E-value: 1.75e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 277 EHHVVHVSPAEKKAVATRI---AAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTAL 353
Cdd:cd18787 2 KQLYVVVEEEEKKLLLLLLlleKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVL 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1110512917 354 IATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:cd18787 82 VATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITF 130
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
70-259 |
2.63e-46 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 158.13 E-value: 2.63e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 70 ALKRTLARQGLTTPSEIQAATLPNSLA-GRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRP--LAVVLAPTRELAQQ 146
Cdd:cd17964 4 SLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSgvSALIISPTRELALQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VAD---SLEPYARSVGVRTAtvVGGMPIHRQARSL-RQGVHLVVATPGRLRDLME--RGDCVLDRVESAVLDEADQMTDM 220
Cdd:cd17964 84 IAAeakKLLQGLRKLRVQSA--VGGTSRRAELNRLrRGRPDILVATPGRLIDHLEnpGVAKAFTDLDYLVLDEADRLLDM 161
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1110512917 221 GFMPQVTAILQEVP---AGGRR-MLFSATLDRNVDTLVRRFLN 259
Cdd:cd17964 162 GFRPDLEQILRHLPeknADPRQtLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
66-262 |
1.37e-45 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 155.95 E-value: 1.37e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 66 DMPeaLKRTLAR----QGLTTPSEI-QAATLPNSLaGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPT 140
Cdd:cd17939 1 DMG--LSEDLLRgiyaYGFEKPSAIqQRAIVPIIK-GRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQ---ALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:cd17939 75 RELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17939 155 GFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
75-267 |
3.28e-45 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 154.96 E-value: 3.28e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 75 LARQGLTTPSEIQAATLPNSLAG-RDVLGRSRTGSGKTLAFGLALLAGMDgrtaEPRRPLAVVLAPTRELAQQVADSLEP 153
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTRELAEQWAEELKK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 154 YARSVGVRTATVVGGMPIHRQARSLRQGV-HLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE 232
Cdd:smart00487 77 LGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
|
170 180 190
....*....|....*....|....*....|....*
gi 1110512917 233 VPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVD 267
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVG 191
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
62-262 |
7.16e-45 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 155.17 E-value: 7.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR--PLAVVLAP 139
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGdgPICLVLAP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 140 TRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTD 219
Cdd:cd18049 106 TRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLD 185
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18049 186 MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYI 228
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
61-263 |
4.42e-44 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 152.07 E-value: 4.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAE--PRrplAVVLA 138
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTvgAR---ALILS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMT 218
Cdd:cd17959 79 PTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17959 159 EMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVL 203
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
71-262 |
2.46e-43 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 150.03 E-value: 2.46e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRP--LAVVLAPTRELAQQVA 148
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKGqvGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 149 DSLEPYARSVG--VRTATVVGGM-PIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLD--RVESAVLDEADQMTDMGFM 223
Cdd:cd17960 81 EVLQSFLEHHLpkLKCQLLIGGTnVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVKvkSLEVLVLDEADRLLDLGFE 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 1110512917 224 PQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPV 199
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
61-262 |
3.55e-43 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 151.70 E-value: 3.55e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR--PLAVVLA 138
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGdgPICLVLA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMT 218
Cdd:cd18050 143 PTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRML 222
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18050 223 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYV 266
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
73-263 |
3.89e-43 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 149.80 E-value: 3.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR----PLAVVLAPTRELAQQV 147
Cdd:cd17951 3 KGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFaLEQEKKLPFIkgegPYGLIVCPSRELARQT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 ADSLEPYARSV------GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd17951 83 HEVIEYYCKALqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMG 162
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17951 163 FEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVT 204
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
71-262 |
1.49e-41 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 145.13 E-value: 1.49e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLAR----QGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQ 146
Cdd:cd17940 6 LKRELLMgifeKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID---PKKDVIQALILVPTRELALQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQV 226
Cdd:cd17940 83 TSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQPII 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 1110512917 227 TAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17940 163 EKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
72-266 |
1.64e-41 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 145.13 E-value: 1.64e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 72 KRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALL--------AGMDGRTaeprrplAVVLAPTREL 143
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLeklyrerwTPEDGLG-------ALIISPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 144 AQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQgVHLVVATPGRLRDLMERG---DCvlDRVESAVLDEADQMTDM 220
Cdd:cd17941 75 AMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpgfDT--SNLQMLVLDEADRILDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSV 266
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
71-262 |
4.14e-41 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 143.88 E-value: 4.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL-GKPRKKKGLRALILAPTRELASQIYRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSVGVRTATVVGGM-PIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17957 80 LLKLSKGTGLRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEI 159
|
170 180 190
....*....|....*....|....*....|....
gi 1110512917 230 LQEVPAGG-RRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17957 160 LAACTNPNlQRSLFSATIPSEVEELARSVMKDPI 193
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
71-262 |
9.09e-41 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 143.07 E-value: 9.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAF---LLPVIIRCLTEHRNPSALILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17962 78 AKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDI 157
|
170 180 190
....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17962 158 LENISHDHQTILVSATIPRGIEQLAGQLLQNPV 190
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
73-263 |
3.69e-40 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 141.25 E-value: 3.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQVADSLE 152
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD---LERRHPQVLILAPTREIAVQIHDVFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 153 PYARSV-GVRTATVVGGMPIHRQARSLRqGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQ 231
Cdd:cd17943 80 KIGKKLeGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFS 158
|
170 180 190
....*....|....*....|....*....|..
gi 1110512917 232 EVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17943 159 SLPKNKQVIAFSATYPKNLDNLLARYMRKPVL 190
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
71-263 |
5.42e-40 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 141.18 E-value: 5.42e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM---DGRTAEPRRPLAVVLAPTRELAQQV 147
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkaKAESGEEQGTRALILVPTRELAQQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 AD---SLEPYARSVgVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERG-DCVLDRVESAVLDEADQMTDMGFM 223
Cdd:cd17961 85 SKvleQLTAYCRKD-VRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVLSYGYE 163
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1110512917 224 PQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17961 164 EDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAI 203
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
71-262 |
1.74e-38 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 137.72 E-value: 1.74e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLA-RQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLAL---LAGMDGRTAEPRRPLAVVLAPTRELAQQ 146
Cdd:cd17949 1 LVSHLKsKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIiqrLLSLEPRVDRSDGTLALVLVPTRELALQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYAR-SVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDC-VLDRVESAVLDEADQMTDMGFMP 224
Cdd:cd17949 81 IYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSfDVSNLRWLVLDEADRLLDMGFEK 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1110512917 225 QVTAILQEV-------------PAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17949 161 DITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPV 211
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
68-262 |
1.17e-37 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 135.17 E-value: 1.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 68 PEALkRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQV 147
Cdd:cd17950 11 PELL-RAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLE---PVDGQVSVLVICHTRELAFQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 ADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGV-HLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM-TDMGFMP 224
Cdd:cd17950 87 SNEYERFSKYMpNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMlEQLDMRR 166
|
170 180 190
....*....|....*....|....*....|....*...
gi 1110512917 225 QVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17950 167 DVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
62-262 |
1.45e-37 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 134.88 E-value: 1.45e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTR 141
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQID---TSLKATQALVLAPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd18046 78 ELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18046 158 FKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
75-263 |
4.42e-36 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 130.66 E-value: 4.42e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAePR----RPLAVVLAPTRELAQQVADS 150
Cdd:cd17958 5 IKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPI-PReqrnGPGVLVLTPTRELALQIEAE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSvGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAIL 230
Cdd:cd17958 84 CSKYSYK-GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKIL 162
|
170 180 190
....*....|....*....|....*....|...
gi 1110512917 231 QEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17958 163 LDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMI 195
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
62-263 |
1.49e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 129.51 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTR 141
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLD---IQVRETQALILSPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd18045 78 ELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd18045 158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIR 199
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
67-246 |
1.20e-34 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 127.05 E-value: 1.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 67 MPEaLKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrtaeprrpLAVVLAPTRELAQQ 146
Cdd:cd17938 7 MPE-LIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV----------VALILEPSRELAEQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYAR---SVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFM 223
Cdd:cd17938 76 TYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNL 155
|
170 180
....*....|....*....|....*....
gi 1110512917 224 PQVTAILQEVP---AGGRR---MLFSATL 246
Cdd:cd17938 156 ETINRIYNRIPkitSDGKRlqvIVCSATL 184
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
72-261 |
3.92e-34 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 125.55 E-value: 3.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 72 KRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRPLAV-VLAPTRELAQQ---- 146
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTGViIISPTRELALQiygv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYARSVGVrtatVVGGMPIHRQARSLRQGVHLVVATPGRLRD-LMERGDCVLDRVESAVLDEADQMTDMGFMPQ 225
Cdd:cd17942 82 AKELLKYHSQTFGI----VIGGANRKAEAEKLGKGVNILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEEE 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 1110512917 226 VTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDP 261
Cdd:cd17942 158 MRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
68-263 |
6.07e-34 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 125.00 E-value: 6.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 68 PEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPTRELAQ 145
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQ---ALCLAPTRELAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 146 QVADSLEPYARSVGVRTATVVGGMPIHRQARSlrqGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM-GFMP 224
Cdd:cd17963 79 QIGEVVEKMGKFTGVKVALAVPGNDVPRGKKI---TAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGD 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 1110512917 225 QVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17963 156 QSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANT 194
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
73-245 |
1.45e-33 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 124.19 E-value: 1.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR---PLAVVLAPTRELAQQVAD 149
Cdd:cd17944 3 KLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRgraPKVLVLAPTRELANQVTK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVrtATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17944 83 DFKDITRKLSV--ACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEI 160
|
170 180
....*....|....*....|....
gi 1110512917 230 L--------QEVPaggRRMLFSAT 245
Cdd:cd17944 161 LsvsykkdsEDNP---QTLLFSAT 181
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
71-250 |
2.19e-27 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 108.49 E-value: 2.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 71 LKRTLARQGLTTPSEIQAATLPNSLAG---------RDVLGRSRTGSGKTLAFGLALLAGMDGRTAepRRPLAVVLAPTR 141
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVV--PRLRALIVVPTK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHL--------VVATPGRLRDLMERGDCV-LDRVESAVLD 212
Cdd:cd17956 79 ELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSGrylsrvdiLVATPGRLVDHLNSTPGFtLKHLRFLVID 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 213 EADQMTDMGF---MPQVTAILQEVPAGG-----------------RRMLFSATLDRNV 250
Cdd:cd17956 159 EADRLLNQSFqdwLETVMKALGRPTAPDlgsfgdanllersvrplQKLLFSATLTRDP 216
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
74-283 |
2.35e-27 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 108.22 E-value: 2.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 74 TLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR----PLAVVLAPTRELAQQVAD 149
Cdd:cd17948 4 ILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGpfnaPRGLVITPSRELAEQIGS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17948 84 VAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKLSHF 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 230 LQEVPAGGRR-------------MLFSATLDRNVDTLvrrfLNDpvVHSVDLSEGAVSTMEHHVV-HV 283
Cdd:cd17948 164 LRRFPLASRRsentdgldpgtqlVLVSATMPSGVGEV----LSK--VIDVDSIETVTSDKLHRLMpHV 225
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
297-394 |
2.97e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 104.21 E-value: 2.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 297 AREGRVIMFLDTKRAVDrmAEHLL-ASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNID 375
Cdd:pfam00271 13 ERGGKVLIFSQTKKTLE--AELLLeKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYD 90
|
90
....*....|....*....
gi 1110512917 376 PPTDHKDYLHRGGRTARAG 394
Cdd:pfam00271 91 LPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
67-263 |
3.55e-23 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 97.45 E-value: 3.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 67 MPEALKRTLARQGLTTPSEIQAATLP---NSLAGRDVLGRSR-------------TGSGKTLAFGLALLAG--------- 121
Cdd:cd17965 15 IKEILKGSNKTDEEIKPSPIQTLAIKkllKTLMRKVTKQTSNeepklevfllaaeTGSGKTLAYLAPLLDYlkrqeqepf 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 122 -MDGRTAEPR----RPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGM-PIHRQ-ARSLRQGVHLVVATPGRLRD 194
Cdd:cd17965 95 eEAEEEYESAkdtgRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFgPSYQRlQLAFKGRIDILVTTPGKLAS 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 195 LMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17965 175 LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVR 243
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
313-394 |
4.10e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 92.27 E-value: 4.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 313 DRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTAR 392
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1110512917 393 AG 394
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
53-263 |
2.41e-22 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 94.70 E-value: 2.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 53 TPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPR 130
Cdd:cd18048 11 TSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVD---ALKL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 131 RPLAVVLAPTRELAQQVADSLEPYAR-SVGVRTATVVGGmpiHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVES 208
Cdd:cd18048 88 YPQCLCLSPTFELALQTGKVVEEMGKfCVGIQVIYAIRG---NRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIdVTNISV 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1110512917 209 AVLDEADQMTDM-GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd18048 165 FVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNI 220
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
60-261 |
7.02e-18 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 81.30 E-value: 7.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVL 137
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ---CLCL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSV-GVRTATVVGGmpiHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEAD 215
Cdd:cd18047 78 SPTYELALQTGKVIEQMGKFYpELKLAYAVRG---NKLERGQKISEQIVIGTPGTVLDWCSKLKFIdPKKIKVFVLDEAD 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1110512917 216 QM-TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDP 261
Cdd:cd18047 155 VMiATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
106-402 |
2.07e-16 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 80.84 E-value: 2.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLaFGLALLAgmdgRTAEPRRplAVVLAPTRELAQQVADSLEPYARSVGVRtatvvggmpihrqARSLRQGVHLV 185
Cdd:COG1061 109 TGTGKTV-LALALAA----ELLRGKR--VLVLVPRRELLEQWAEELRRFLGDPLAG-------------GGKKDSDAPIT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 186 VATP------GRLRDLMERGDCVldrvesaVLDEADQMTDMGFmpqvTAILQEVPAGgRRMLFSATLDRNVDTLVRRFLN 259
Cdd:COG1061 169 VATYqslarrAHLDELGDRFGLV-------IIDEAHHAGAPSY----RRILEAFPAA-YRLGLTATPFRSDGREILLFLF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 260 DPVVHSVDLSE----GAVSTMEHHVVHVS----------------------PAEKKAVATRIAAREG---RVIMFLDTKR 310
Cdd:COG1061 237 DGIVYEYSLKEaiedGYLAPPEYYGIRVDltderaeydalserlrealaadAERKDKILRELLREHPddrKTLVFCSSVD 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 311 AVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRT 390
Cdd:COG1061 317 HAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRG 396
|
330
....*....|..
gi 1110512917 391 ARAGESGNVVTL 402
Cdd:COG1061 397 LRPAPGKEDALV 408
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
50-402 |
2.45e-15 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 77.95 E-value: 2.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 50 VTVTPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrtAEP 129
Cdd:COG1205 24 VRTIPAREARYAPWPDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAL----LED 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 130 RRPLAVVLAPTRELAQQVADSLEPYARSVG--VRTATVVGGMPihRQARS-LRQGVHLVVATP-----------GRLRDL 195
Cdd:COG1205 100 PGATALYLYPTKALARDQLRRLRELAEALGlgVRVATYDGDTP--PEERRwIREHPDIVLTNPdmlhygllphhTRWARF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 196 MERgdcvLDRVesaVLDEADQMTdmG-FMPQVTAILqevpaggRRML-----------F---SATLDrNVDTLVRRFLND 260
Cdd:COG1205 178 FRN----LRYV---VIDEAHTYR--GvFGSHVANVL-------RRLRricrhygsdpqFilaSATIG-NPAEHAERLTGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 261 PVVHsVDLSeGAVSTMEHHVVHVSPAEKKAV-------ATRIAA---REG-RVIMFLDTKRAVDRMAEHL---LASGVLA 326
Cdd:COG1205 241 PVTV-VDED-GSPRGERTFVLWNPPLVDDGIrrsalaeAARLLAdlvREGlRTLVFTRSRRGAELLARYArraLREPDLA 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 327 ---APLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG1205 319 drvAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLV 397
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
97-245 |
6.18e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 71.67 E-value: 6.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 97 GRDVLGRSRTGSGKTLAFGLALLagmdgRTAEPRRPLAVVLAPTRELAQQVADSLEPYARSvGVRTATVVGGMPIHRQAR 176
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAAL-----LLLLKKGKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSSAEEREK 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1110512917 177 SLRQGVHLVVATPGRLRDLMERGDC-VLDRVESAVLDEADQMT-DMGFMPQVT-AILQEVPAGGRRMLFSAT 245
Cdd:cd00046 75 NKLGDADIIIATPDMLLNLLLREDRlFLKDLKLIIVDEAHALLiDSRGALILDlAVRKAGLKNAQVILLSAT 146
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
95-402 |
4.39e-13 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 70.55 E-value: 4.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 95 LAGRDVLGRSRTGSGKTLAFGL-ALLagMDGrtaeprrpLAVVLAPTRELAQ-QVaDSLepyaRSVGVRTATVVGGMPIH 172
Cdd:COG0514 30 LAGRDALVVMPTGGGKSLCYQLpALL--LPG--------LTLVVSPLIALMKdQV-DAL----RAAGIRAAFLNSSLSAE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 173 RQA---RSLRQG-VHLVVATPGRL-----RDLMERGDCVLdrvesAVLDEA--------DqmtdmgFMP------QVTAI 229
Cdd:COG0514 95 ERRevlRALRAGeLKLLYVAPERLlnprfLELLRRLKISL-----FAIDEAhcisqwghD------FRPdyrrlgELRER 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 230 LQEVPaggrRMLFSATLDRNV-DTLVRRF-LNDP--VVHSVD-----LSegavstmehhVVHVSPAEKKA-VATRIAARE 299
Cdd:COG0514 164 LPNVP----VLALTATATPRVrADIAEQLgLEDPrvFVGSFDrpnlrLE----------VVPKPPDDKLAqLLDFLKEHP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 GR--VIMFLdTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNvaARGIHVDGLDL--VVNID 375
Cdd:COG0514 230 GGsgIVYCL-SRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATI--AFGMGIDKPDVrfVIHYD 306
|
330 340
....*....|....*....|....*..
gi 1110512917 376 PPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0514 307 LPKSIEAYYQEIGRAGRDGLPAEALLL 333
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
68-356 |
5.45e-11 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 64.15 E-value: 5.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 68 PEALKRTLARQGLT--TPSeiQAATLPNSL-AGRDVLGRSRTGSGKTLafgLALLAgMdgRTAEPRRPLAVVLAPTRELA 144
Cdd:COG1204 8 LEKVIEFLKERGIEelYPP--QAEALEAGLlEGKNLVVSAPTASGKTL---IAELA-I--LKALLNGGKALYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 145 QQVADSLEPYARSVGVRTATVVGgmPIHRQARSLRQgVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM--GF 222
Cdd:COG1204 80 SEKYREFKRDFEELGIKVGVSTG--DYDSDDEWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDEsrGP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 223 MPQVT-AILQEVPAGGRRMLFSATLDrNVDTlVRRFLNDPVVHS----VDLSEGavsTMEHHVVHVSPAEKK------AV 291
Cdd:COG1204 157 TLEVLlARLRRLNPEAQIVALSATIG-NAEE-IAEWLDAELVKSdwrpVPLNEG---VLYDGVLRFDDGSRRskdptlAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 292 ATRIAAREGRVIMFLDTKRAVDRMAEHL------------------LASGVLAAPL-------------------HGGRS 334
Cdd:COG1204 232 ALDLLEEGGQVLVFVSSRRDAESLAKKLadelkrrltpeereeleeLAEELLEVSEethtnekladclekgvafhHAGLP 311
|
330 340
....*....|....*....|..
gi 1110512917 335 QPQRTRTLDQFKRGDVTALIAT 356
Cdd:COG1204 312 SELRRLVEDAFREGLIKVLVAT 333
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
334-396 |
3.98e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 57.60 E-value: 3.98e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1110512917 334 SQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRtARAGES 396
Cdd:cd18802 75 TQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
87-394 |
4.27e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 61.27 E-value: 4.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 87 QAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAgMDGrtaeprrpLAVVLAPTRELAQQVADSLEPYarsvGVRTATVV 166
Cdd:PRK11057 30 QQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV-LDG--------LTLVVSPLISLMKDQVDQLLAN----GVAAACLN 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 167 GGMPIHRQA---RSLRQG-VHLVVATPGRL--RDLMERgdcvLDRVESAVL--DEADQMTDMG--FMPQVTAILQ----- 231
Cdd:PRK11057 97 STQTREQQLevmAGCRTGqIKLLYIAPERLmmDNFLEH----LAHWNPALLavDEAHCISQWGhdFRPEYAALGQlrqrf 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 232 -EVPAggrrMLFSATLD---RNvDTLVRRFLNDPVVH--SVDLSEGAVSTMEHHvvhvSPAEKkaVATRIAAREGRV-IM 304
Cdd:PRK11057 173 pTLPF----MALTATADdttRQ-DIVRLLGLNDPLIQisSFDRPNIRYTLVEKF----KPLDQ--LMRYVQEQRGKSgII 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 305 FLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYL 384
Cdd:PRK11057 242 YCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYY 321
|
330
....*....|
gi 1110512917 385 HRGGRTARAG 394
Cdd:PRK11057 322 QETGRAGRDG 331
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
254-402 |
1.48e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 59.74 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 254 VRRFLNDPVVHSvdlsegAVSTME-HHVVHvsPAEKKAV----ATRIAAREGRVIMFL---DTkraVDRMAEHLLASGVL 325
Cdd:COG1111 311 SKRLVSDPRFRK------AMRLAEeADIEH--PKLSKLReilkEQLGTNPDSRIIVFTqyrDT---AEMIVEFLSEPGIK 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 326 AAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDP-PTDHKdYLHRGGRTARAGEs 396
Cdd:COG1111 380 AGRFVGqaskegdkGLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPvPSEIR-SIQRKGRTGRKRE- 457
|
....*.
gi 1110512917 397 GNVVTL 402
Cdd:COG1111 458 GRVVVL 463
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
301-402 |
2.31e-08 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 52.74 E-value: 2.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 301 RVIMFLDTKRAVDRMAEHLL--ASGVLAAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDL 370
Cdd:cd18801 32 RVIIFSEFRDSAEEIVNFLSkiRPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDL 111
|
90 100 110
....*....|....*....|....*....|..
gi 1110512917 371 VVNIDPPTDHKDYLHRGGRTARaGESGNVVTL 402
Cdd:cd18801 112 IICYDASPSPIRMIQRMGRTGR-KRQGRVVVL 142
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
95-214 |
3.05e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.03 E-value: 3.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 95 LAGRDVLGRSRTGSGKTLAFGLALLAGMdgRTAEPRrplAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQ 174
Cdd:cd17921 15 LSGDSVLVSAPTSSGKTLIAELAILRAL--ATSGGK---AVYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKL 89
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1110512917 175 ARSLRQgvhLVVATPGRLrDLMER--GDCVLDRVESAVLDEA 214
Cdd:cd17921 90 LLAEAD---ILVATPEKL-DLLLRngGERLIQDVRLVVVDEA 127
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
301-402 |
3.21e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 55.65 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 301 RVIMFL---DTkraVDRMAEHLLASGVLAAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLD 369
Cdd:PRK13766 367 RIIVFTqyrDT---AEKIVDLLEKEGIKAVRFVGqaskdgdkGMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVD 443
|
90 100 110
....*....|....*....|....*....|....
gi 1110512917 370 LVVNIDP-PTDHKdYLHRGGRTARaGESGNVVTL 402
Cdd:PRK13766 444 LVIFYEPvPSEIR-SIQRKGRTGR-QEEGRVVVL 475
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
87-214 |
1.83e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 50.66 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 87 QAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAgmdgRTAEPRRPLAVVLAPTRELAQQVADSLEPYARSV--GVRTAT 164
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILE----ALLRDPGSRALYLYPTKALAQDQLRSLRELLEQLglGIRVAT 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 165 VVGGMPIHRQARSLRQGVHLVVATPGRLRDLM----ERGDCVLDRVESAVLDEA 214
Cdd:cd17923 81 YDGDTPREERRAIIRNPPRILLTNPDMLHYALlphhDRWARFLRNLRYVVLDEA 134
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
69-264 |
1.06e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 49.07 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 69 EALKRTLarqGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGL-ALLAGmdgrtaeprrPLAVVLAPTRELAQ-Q 146
Cdd:cd17920 2 QILKEVF---GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLpALLLD----------GVTLVVSPLISLMQdQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VaDSLepyaRSVGVRTATVVGGMPIHRQ----ARSLRQGVHLVVATPGRLR--DLME--RGDCVLDRVESAVLDEA---- 214
Cdd:cd17920 69 V-DRL----QQLGIRAAALNSTLSPEEKrevlLRIKNGQYKLLYVTPERLLspDFLEllQRLPERKRLALIVVDEAhcvs 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1110512917 215 ----DQMTDMGFMPQVTAILQEVPaggrRMLFSATLDRNV--DTLVRRFLNDPVVH 264
Cdd:cd17920 144 qwghDFRPDYLRLGRLRRALPGVP----ILALTATATPEVreDILKRLGLRNPVIF 195
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
106-198 |
1.97e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 48.12 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLAFGLALLAGMDGRTAEPR-RPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGgmpiHRQARSLR--QGV 182
Cdd:cd18023 26 TGSGKTVLFELAILRLLKERNPLPWgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLSCAELTG----DTEMDDTFeiQDA 101
|
90
....*....|....*.
gi 1110512917 183 HLVVATPGRLrDLMER 198
Cdd:cd18023 102 DIILTTPEKW-DSMTR 116
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
278-396 |
8.65e-06 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 45.33 E-value: 8.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 278 HHVVHVSP---------AEKKAVATRIAA---REG-RVIMFLDTKRAVDRMAEHLLASGVLAAPL-------HGGRSQPQ 337
Cdd:cd18797 1 HFVLWNPPlldrkdgerGSARREAARLFAdlvRAGvKTIVFCRSRKLAELLLRYLKARLVEEGPLaskvasyRAGYLAED 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 338 RTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGES 396
Cdd:cd18797 81 RREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKD 139
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
351-402 |
1.08e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 43.08 E-value: 1.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1110512917 351 TALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
282-396 |
2.28e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 44.18 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 282 HVSPAEKKAVATRIAAREGRVImFLDTKRAVDRMAEHLLA-----SGVLAAPLHGG-RSQPQRTRTLDQFKRGDVTALIA 355
Cdd:cd18796 22 ESGADAYAEVIFLLERHKSTLV-FTNTRSQAERLAQRLRElcpdrVPPDFIALHHGsLSRELREEVEAALKRGDLKVVVA 100
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1110512917 356 TNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGES 396
Cdd:cd18796 101 TSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGA 141
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
81-377 |
9.45e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 44.71 E-value: 9.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 81 TTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAfglALLAGMD-----GRTAEPRRPLAVV----------------LAP 139
Cdd:COG1201 23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTLA---AFLPALDelarrPRPGELPDGLRVLyisplkalandiernlRAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 140 TRELAQQVADSLEPYarSVGVRTatvvGGMPIHRQARSLRQGVHLVVATPGRLRdLM---ERGDCVLDRVESAVLDE--- 213
Cdd:COG1201 100 LEEIGEAAGLPLPEI--RVGVRT----GDTPASERQRQRRRPPHILITTPESLA-LLltsPDARELLRGVRTVIVDEiha 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 214 ------ADQMtdmgfmpQVT-AILQE-VPAGGRRMLFSATLdRNVDTlVRRFL----NDPVVHSVDLSEGA--------- 272
Cdd:COG1201 173 lagskrGVHL-------ALSlERLRAlAPRPLQRIGLSATV-GPLEE-VARFLvgyeDPRPVTIVDAGAGKkpdlevlvp 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 273 VSTMEHHVV---HVSPAEKKAVATRIaaREGR-VIMFLDTKRAVDRMAEHLLA----SGVLAAPLHGGRSQPQRTRTLDQ 344
Cdd:COG1201 244 VEDLIERFPwagHLWPHLYPRVLDLI--EAHRtTLVFTNTRSQAERLFQRLNElnpeDALPIAAHHGSLSREQRLEVEEA 321
|
330 340 350
....*....|....*....|....*....|...
gi 1110512917 345 FKRGDVTALIATNVAARGIHVDGLDLVVNIDPP 377
Cdd:COG1201 322 LKAGELRAVVATSSLELGIDIGDVDLVIQVGSP 354
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
97-213 |
1.24e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 42.19 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 97 GRDVLGRSRTGSGKTLAfglALLAGMDGRTAEPRRPLAVV-LAPTRELAQQVADSLEPYAR------SVGVRTatvvGGM 169
Cdd:cd17922 1 GRNVLIAAPTGSGKTEA---AFLPALSSLADEPEKGVQVLyISPLKALINDQERRLEEPLDeidleiPVAVRH----GDT 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1110512917 170 PIHRQARSLRQGVHLVVATPGRLRDLM--ERGDCVLDRVESAVLDE 213
Cdd:cd17922 74 SQSEKAKQLKNPPGILITTPESLELLLvnKKLRELFAGLRYVVVDE 119
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
106-372 |
1.71e-04 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 43.76 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLAFGLALL--AGMDGRTA--EPRRplavvLApTRELAQQVADSL-EPYARSVG--VRTATVVGgmpihRQARsl 178
Cdd:PRK11664 29 TGAGKSTWLPLQLLqhGGINGKIImlEPRR-----LA-ARNVAQRLAEQLgEKPGETVGyrMRAESKVG-----PNTR-- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 179 rqgvhLVVATPGRLRDLMERgDCVLDRVESAVLDE-------ADQmtdmgfmpqVTAILQEVPAGGR---RML-FSATLD 247
Cdd:PRK11664 96 -----LEVVTEGILTRMIQR-DPELSGVGLVILDEfherslqADL---------ALALLLDVQQGLRddlKLLiMSATLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 248 RnvDTLVRRFLNDPVVhsvdLSEGAVSTMEHHVVHVSPAEK--KAVATRIA----AREGRVIMFLDTKRAVDRMAEHL-- 319
Cdd:PRK11664 161 N--DRLQQLLPDAPVI----VSEGRSFPVERRYQPLPAHQRfdEAVARATAellrQESGSLLLFLPGVGEIQRVQEQLas 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 320 -LASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVV 372
Cdd:PRK11664 235 rVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVV 288
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
106-214 |
2.04e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 42.25 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLafgLALLA----GMDGRTAEPRRPLAVVLAPTRELAQQVADSLEPYarsVGVRTATVVGGMPIHRQARSLRQG 181
Cdd:cd18034 25 TGSGKTL---IAVMLikemGELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRSH---TDLKVGEYSGEMGVDKWTKERWKE 98
|
90 100 110
....*....|....*....|....*....|....*..
gi 1110512917 182 V----HLVVATPGRLRDLMERGDCVLDRVESAVLDEA 214
Cdd:cd18034 99 ElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
277-366 |
4.43e-04 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 42.57 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 277 EHHVVHVSPAEKKAVATRIAARE----------GRVIMFLDTKRAVDRMAEHLlasGVLAAPLHGGRSQPQRTRTLDQFK 346
Cdd:COG1202 395 ERHLTFADGREKIRIINKLVKREfdtksskgyrGQTIIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFA 471
|
90 100
....*....|....*....|
gi 1110512917 347 RGDVTALIATnvAARGIHVD 366
Cdd:COG1202 472 DQELAAVVTT--AALAAGVD 489
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
294-377 |
1.18e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 40.98 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 294 RIAAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTA--LIATNVAARGIHVDGLDLV 371
Cdd:COG0553 544 ELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPvfLISLKAGGEGLNLTAADHV 623
|
....*.
gi 1110512917 372 VNIDPP 377
Cdd:COG0553 624 IHYDLW 629
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
298-395 |
1.53e-03 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 38.34 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNvaARGIHVDGLD--LVVNID 375
Cdd:cd18794 29 LGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATV--AFGMGIDKPDvrFVIHYS 106
|
90 100
....*....|....*....|
gi 1110512917 376 PPTDHKDYLHRGGRTARAGE 395
Cdd:cd18794 107 LPKSMESYYQESGRAGRDGL 126
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
96-198 |
5.72e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 37.69 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 96 AGRDVLGRS-----RTGSGKTlAFGL--ALLAGMDGRtaeprRPLAVVlaPTRELAQQVADSLEPYARSVGVRTATVV-- 166
Cdd:cd17924 26 AKRLLRGKSfaiiaPTGVGKT-TFGLatSLYLASKGK-----RSYLIF--PTKSLVKQAYERLSKYAEKAGVEVKILVyh 97
|
90 100 110
....*....|....*....|....*....|....*.
gi 1110512917 167 GGMPIHRQARSLRQ----GVHLVVATPGRLRDLMER 198
Cdd:cd17924 98 SRLKKKEKEELLEKiekgDFDILVTTNQFLSKNFDL 133
|
|
| |
