Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain [Microterricola viridarii]
M23 family metallopeptidase( domain architecture ID 11432770)
M23 family metallopeptidase lyses bacterial cell wall peptidoglycans
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
NlpD | COG0739 | Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ... |
246-441 | 3.44e-46 | ||||
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis]; : Pssm-ID: 440502 [Multi-domain] Cd Length: 196 Bit Score: 158.60 E-value: 3.44e-46
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YqiK super family | cl34451 | Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; |
58-142 | 1.38e-03 | ||||
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; The actual alignment was detected with superfamily member COG2268: Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 41.01 E-value: 1.38e-03
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Name | Accession | Description | Interval | E-value | ||||
NlpD | COG0739 | Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ... |
246-441 | 3.44e-46 | ||||
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440502 [Multi-domain] Cd Length: 196 Bit Score: 158.60 E-value: 3.44e-46
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Peptidase_M23 | pfam01551 | Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ... |
341-436 | 1.28e-34 | ||||
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown. Pssm-ID: 460250 [Multi-domain] Cd Length: 96 Bit Score: 124.20 E-value: 1.28e-34
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M23_peptidase | cd12797 | M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ... |
341-427 | 8.58e-32 | ||||
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity. Pssm-ID: 410984 [Multi-domain] Cd Length: 85 Bit Score: 116.15 E-value: 8.58e-32
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PRK11649 | PRK11649 | putative peptidase; Provisional |
319-436 | 1.00e-17 | ||||
putative peptidase; Provisional Pssm-ID: 236946 [Multi-domain] Cd Length: 439 Bit Score: 85.10 E-value: 1.00e-17
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YqiK | COG2268 | Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; |
58-142 | 1.38e-03 | ||||
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 41.01 E-value: 1.38e-03
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SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
55-214 | 1.46e-03 | ||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.20 E-value: 1.46e-03
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
55-165 | 1.78e-03 | ||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 40.56 E-value: 1.78e-03
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Name | Accession | Description | Interval | E-value | ||||||
NlpD | COG0739 | Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ... |
246-441 | 3.44e-46 | ||||||
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440502 [Multi-domain] Cd Length: 196 Bit Score: 158.60 E-value: 3.44e-46
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Peptidase_M23 | pfam01551 | Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ... |
341-436 | 1.28e-34 | ||||||
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown. Pssm-ID: 460250 [Multi-domain] Cd Length: 96 Bit Score: 124.20 E-value: 1.28e-34
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EnvC | COG4942 | Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
55-443 | 1.84e-34 | ||||||
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 132.19 E-value: 1.84e-34
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M23_peptidase | cd12797 | M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ... |
341-427 | 8.58e-32 | ||||||
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity. Pssm-ID: 410984 [Multi-domain] Cd Length: 85 Bit Score: 116.15 E-value: 8.58e-32
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SpoIIQ2 | COG5821 | Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell ... |
309-440 | 1.47e-28 | ||||||
Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 444523 [Multi-domain] Cd Length: 200 Bit Score: 111.27 E-value: 1.47e-28
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PRK11649 | PRK11649 | putative peptidase; Provisional |
319-436 | 1.00e-17 | ||||||
putative peptidase; Provisional Pssm-ID: 236946 [Multi-domain] Cd Length: 439 Bit Score: 85.10 E-value: 1.00e-17
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SpoIVFA | COG5833 | Stage IV sporulation protein SpoIVFA, regulates SpoIVFB [Cell cycle control, cell division, ... |
312-437 | 6.89e-16 | ||||||
Stage IV sporulation protein SpoIVFA, regulates SpoIVFB [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 444535 [Multi-domain] Cd Length: 219 Bit Score: 76.18 E-value: 6.89e-16
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SpoIIQ | COG5820 | Stage II sporulation protein SpoIIQ, required for engulfement [Cell cycle control, cell ... |
339-441 | 3.95e-14 | ||||||
Stage II sporulation protein SpoIIQ, required for engulfement [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 444522 [Multi-domain] Cd Length: 224 Bit Score: 71.49 E-value: 3.95e-14
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nlpD | PRK10871 | murein hydrolase activator NlpD; |
311-443 | 4.82e-12 | ||||||
murein hydrolase activator NlpD; Pssm-ID: 236782 [Multi-domain] Cd Length: 319 Bit Score: 66.78 E-value: 4.82e-12
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CwlO1 | COG3883 | Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
60-432 | 4.23e-11 | ||||||
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 64.47 E-value: 4.23e-11
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YqiK | COG2268 | Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; |
58-142 | 1.38e-03 | ||||||
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]; Pssm-ID: 441869 [Multi-domain] Cd Length: 439 Bit Score: 41.01 E-value: 1.38e-03
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SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
55-214 | 1.46e-03 | ||||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.20 E-value: 1.46e-03
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
55-165 | 1.78e-03 | ||||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 40.56 E-value: 1.78e-03
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Surf_Exclu_PgrA | TIGR04320 | SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
56-136 | 3.57e-03 | ||||||
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion. Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 39.32 E-value: 3.57e-03
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PRK11637 | PRK11637 | AmiB activator; Provisional |
371-440 | 5.78e-03 | ||||||
AmiB activator; Provisional Pssm-ID: 236942 [Multi-domain] Cd Length: 428 Bit Score: 38.91 E-value: 5.78e-03
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Smc | COG1196 | Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
55-141 | 7.92e-03 | ||||||
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 38.76 E-value: 7.92e-03
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Surf_Exclu_PgrA | TIGR04320 | SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
56-134 | 8.89e-03 | ||||||
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion. Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 38.17 E-value: 8.89e-03
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Blast search parameters | ||||
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