NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1077060234|emb|SBP56897|]
View 

tectorin alpha [Nothobranchius furzeri]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1845-2096 3.10e-53

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 187.81  E-value: 3.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1845 CKHAQMEVSISKCKLFQLGFEREDVR--VNDERCAG---IEGEDFISFHINNTkgHCGSIVQSNGTHIMYKNTVWIESVN 1919
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1920 NtGNVITRDKTINVEFSCAYELDLKISLETVLKPMLSVINltlPTQEGNFITKMALYKNSSYRNPYREGEVVLSTRDILF 1999
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPPSPVPIT---VSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 2000 VGVFVEGADENQLILIVNMCWATPSRYSSDRLRYIIIERGCPNTKDNTIG--MAENGVSLTCRFHVTVFKFIGDY-DEVH 2076
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1077060234 2077 LHCDVSLCDSDTNACKVNCP 2096
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
99-251 3.66e-52

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 180.70  E-value: 3.66e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234    99 PLWADVHNGIRGDVYYRETTDPELLERATQDVQKYFKNMPTFTASWVFIATWHQVTFYGGSQTTPVNTFQTVLISDGVVS 178
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234   179 YSMFNYGEITWSTGTASGGDPltglgGTTAQAGFNGGDIGHFFNLPGSRSNDVVNIEQTTNVNVPGRWFFRVD 251
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 323-479 4.78e-45

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 160.61  E-value: 4.78e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  323 CVVFGDPHYHTFDGFLYHFQGTCSYLLARPCWEmLGLPFFSVEAKNENRGvASVSWLRDVTVEVYGHRVMIPKGslGTVQ 402
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSE-EPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234  403 VDGLVKTLPVQLQLGAVKVYQSGVA-VALETDFGLLVTYDGQHYASISLPSSYFNNTCGLCGNYNDDPADDPVLPDGS 479
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1531-1682 1.20e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 130.57  E-value: 1.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1531 CVASGGGVFRTFDGASLRLPASCSFVLSTNCHKLPDLSFQLIANFDKWSTPNLTTIShVYLYINEENI-LISGSTVKVNG 1609
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVCLKS-VTVIVGDLEItLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1610 TPVSVPFLTGLMTRLSTSEGFIVIDTPQDIQVRYNR--FNTLSITMGQRLQNKVCGLCGNFNGDPSDDYITSRGK 1682
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGdgRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 518-593 1.07e-29

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 113.59  E-value: 1.07e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234   518 TYFRSDYCGLINKTDGPFRDCRAVVDPTAFVYSCVYDMCSYRDNMTTLCHAIQAYALACQALGVTIRPWRTRTFCP 593
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 715-873 6.97e-22

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 6.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   715 GVCSVTQTSIASSFDGTFLLFPDDSSYYLLKLCGPTPAngsvVEVKIGRRLMNKGPVWKRPVIVTVANLEAQVGGSDfDT 794
Cdd:smart00216   10 PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPT----FSVLLKNVPCGGGATCLKSVKVELNGDEIELKDDN-GK 84

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234   795 VKVNGEPVVLPFVHPMETMMIYKAPGNATVVESRGLLRVQYTRQGFLNISLSTIFYNVTCGLCGVFNSNVTDDLRLPNG 873
Cdd:smart00216   85 VTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPDG 163
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 917-986 1.01e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 84.74  E-value: 1.01e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  917 MCGNINDpgNSSFLACHSVVNPSPFFRNCLYNMCVREGNRSALCSSLHAYATACQDAQIGLASWRSATNC 986
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1338-1412 1.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 84.70  E-value: 1.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  1338 EPEAVRLCGLIVDRGGAFARCHSKVAPAFFYQSCLQDTCLDQGAQDTICNWLQVYASTCQAQGVPVTGWRSDTPC 1412
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 990-1044 2.10e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.96  E-value: 2.10e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  990 CPDNSHFEECTSACPLTCTNLDEPeEPCPLPCQEGCQCEDGFAL-RDGLCVARSDC 1044
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAP-PPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 596-649 2.36e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.36e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  596 CPEFSQYQVCTSACPASCSDLTSPLYCVHPCTEGCQCDPGYVLS-GSRCVQQDDC 649
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1416-1469 9.83e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 67.34  E-value: 9.83e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1416 CPPNSHYSSCVSVCPPQCAPARGQRDCNQDCTEGCQCDQGYVLN-GKSCILSQNC 1469
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1724-1795 8.36e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 65.44  E-value: 8.36e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234  1724 QGEDACQKLTQLKGFFQPCHGLLDPRPFYQSCYLDGC-YNHRKAQVCGSLAAYAEACRSLGTLTTKWIAQENC 1795
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
VWD super family cl47031
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1098-1256 5.54e-12

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


The actual alignment was detected with superfamily member smart00216:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 65.89  E-value: 5.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1098 YFCQPRTEALCVVAGYGHFLPFGGVPFELQSSCTlrmaTSVCRrggrentlTSGTFPQFKLAARNEERDTGQAiWLRGFV 1177
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCY----YVLAQ--------DCSSEPTFSVLLKNVPCGGGAT-CLKSVK 68

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1178 LEVYEYEIEVSRSyRNTVTVNKERLYLPLKLGLGKVNIFTSGMMLILETDFGL-KAAFDWNTLLLLTLPRDLYNTSCGLC 1256
Cdd:smart00216   69 VELNGDEIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLC 147
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2126-2160 7.87e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 7.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1077060234 2126 CEDDNGGCEQICTSKGTGPICSCVTG-MLQPDGQSC 2160
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 1471-1524 3.96e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 43.06  E-value: 3.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1077060234 1471 CYTDGKYYEPKQLFWNSDCTKRCQCIGrNLVQCDPRRCKAEEECTLRHGVRGCF 1524
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 261-316 7.89e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 36.51  E-value: 7.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  261 CSHNGRYYRRGEiFWLSDQCSQRCRCLdiNNEVQCLEAPCGQFENCEQQEGAFFCQ 316
Cdd:pfam12714    2 KDAQGNYIPAGK-TWFSSGCTQSCTCT--GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1845-2096 3.10e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 187.81  E-value: 3.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1845 CKHAQMEVSISKCKLFQLGFEREDVR--VNDERCAG---IEGEDFISFHINNTkgHCGSIVQSNGTHIMYKNTVWIESVN 1919
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1920 NtGNVITRDKTINVEFSCAYELDLKISLETVLKPMLSVINltlPTQEGNFITKMALYKNSSYRNPYREGEVVLSTRDILF 1999
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPPSPVPIT---VSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 2000 VGVFVEGADENQLILIVNMCWATPSRYSSDRLRYIIIERGCPNTKDNTIG--MAENGVSLTCRFHVTVFKFIGDY-DEVH 2076
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1077060234 2077 LHCDVSLCDSDTNACKVNCP 2096
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1845-2096 5.45e-53

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 187.21  E-value: 5.45e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1845 CKHAQMEVSISKCKLFQLGFEREDVRVNDERCAG---IEGEDFISFHINNTKghCGSIVQSNGTHIMYKNTVWIESVNNt 1921
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSPFHP- 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1922 gNVITRDKTINVEFSCAYELDLKISLETVLKPMLSVINLtlPTQEGNFITKMALYKNSSYRNPYREGEVVLstRDILFVG 2001
Cdd:smart00241   79 -GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELS--SVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYHE 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  2002 VFVEGADENQLILIVNMCWATPSRYSSDRLRYIIIERGCPNTKDNTIGMA-ENGVSLTCRFHVTVFKFIgDYDEVHLHCD 2080
Cdd:smart00241  154 WECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPyNSNPLHRARFSVKVFKFA-DRSLVYFHCQ 232

                           250
                    ....*....|....*...
gi 1077060234  2081 VSLCDSDTNA--CKVNCP 2096
Cdd:smart00241  233 IRLCDKDDGSscDGPACS 250
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
99-251 3.66e-52

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 180.70  E-value: 3.66e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234    99 PLWADVHNGIRGDVYYRETTDPELLERATQDVQKYFKNMPTFTASWVFIATWHQVTFYGGSQTTPVNTFQTVLISDGVVS 178
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234   179 YSMFNYGEITWSTGTASGGDPltglgGTTAQAGFNGGDIGHFFNLPGSRSNDVVNIEQTTNVNVPGRWFFRVD 251
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 323-479 4.78e-45

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 160.61  E-value: 4.78e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  323 CVVFGDPHYHTFDGFLYHFQGTCSYLLARPCWEmLGLPFFSVEAKNENRGvASVSWLRDVTVEVYGHRVMIPKGslGTVQ 402
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSE-EPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234  403 VDGLVKTLPVQLQLGAVKVYQSGVA-VALETDFGLLVTYDGQHYASISLPSSYFNNTCGLCGNYNDDPADDPVLPDGS 479
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 314-478 1.31e-44

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 159.49  E-value: 1.31e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   314 FCQPTRtSTCVVFGDPHYHTFDGFLYHFQGTCSYLLARPCWEmlgLPFFSVEAKNENRGvASVSWLRDVTVEVYGHrVMI 393
Cdd:smart00216    4 TQEECS-PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS---EPTFSVLLKNVPCG-GGATCLKSVKVELNGD-EIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   394 PKGSLGTVQVDGLVKTLPVQLQLGAVKVYQSGVAVALETDFGLL-VTYDGQHYASISLPSSYFNNTCGLCGNYNDDPADD 472
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDD 157


                    ....*.
gi 1077060234   473 PVLPDG 478
Cdd:smart00216  158 FRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 164-252 3.31e-37

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 135.50  E-value: 3.31e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  164 VNTFQTVLISDGVVSYSMFNYGE--ITWSTGTASGGdpLTGLGGTTAQAGFNGGD-IGHFFNLPGSRSNDVVNIEQTTNV 240
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDggIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1077060234  241 NVPGRWFFRVDT 252
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1531-1682 1.20e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 130.57  E-value: 1.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1531 CVASGGGVFRTFDGASLRLPASCSFVLSTNCHKLPDLSFQLIANFDKWSTPNLTTIShVYLYINEENI-LISGSTVKVNG 1609
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVCLKS-VTVIVGDLEItLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1610 TPVSVPFLTGLMTRLSTSEGFIVIDTPQDIQVRYNR--FNTLSITMGQRLQNKVCGLCGNFNGDPSDDYITSRGK 1682
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGdgRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1521-1681 7.88e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.90  E-value: 7.88e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1521 RGCFARRSQH-CVASGGGVFRTFDGASLRLPASCSFVLSTNCHKLPDLSFqLIANFDkwSTPNLTTISHVYLYINEENIL 1599
Cdd:smart00216    1 WCCTQEECSPtCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFSV-LLKNVP--CGGGATCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1600 ISGS--TVKVNGTPVSVPFLTGLMT-RLSTSEGFIVIDTPQDI-QVRYNRFNTLSITMGQRLQNKVCGLCGNFNGDPSDD 1675
Cdd:smart00216   78 LKDDngKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDD 157


                    ....*.
gi 1077060234  1676 YITSRG 1681
Cdd:smart00216  158 FRTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 518-593 1.07e-29

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 113.59  E-value: 1.07e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234   518 TYFRSDYCGLINKTDGPFRDCRAVVDPTAFVYSCVYDMCSYRDNMTTLCHAIQAYALACQALGVTIRPWRTRTFCP 593
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 524-592 2.79e-22

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 92.06  E-value: 2.79e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234  524 YCGLINKtDGPFRDCRAVVDPTAFVYSCVYDMCSYRDNMTTLCHAIQAYALACQALGVTIRPWRTRTFC 592
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 715-873 6.97e-22

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 6.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   715 GVCSVTQTSIASSFDGTFLLFPDDSSYYLLKLCGPTPAngsvVEVKIGRRLMNKGPVWKRPVIVTVANLEAQVGGSDfDT 794
Cdd:smart00216   10 PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPT----FSVLLKNVPCGGGATCLKSVKVELNGDEIELKDDN-GK 84

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234   795 VKVNGEPVVLPFVHPMETMMIYKAPGNATVVESRGLLRVQYTRQGFLNISLSTIFYNVTCGLCGVFNSNVTDDLRLPNG 873
Cdd:smart00216   85 VTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 717-874 1.13e-21

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 93.59  E-value: 1.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  717 CSVTQTSIASSFDGTFLLFPDDSSYYLLKLCGPTPANGSVVEVKIGRRlmNKGPVWKRPVIVTVANLEAQVGgsDFDTVK 796
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNG--GASGVCLKSVTVIVGDLEITLQ--KGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234  797 VNGEPVVLPFVHPMETMMIYKAPGNATVVESRGLLRVQYTRQGFLNISLSTIFYNVTCGLCGVFNSNVTDDLRLPNGR 874
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 917-986 1.01e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 84.74  E-value: 1.01e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  917 MCGNINDpgNSSFLACHSVVNPSPFFRNCLYNMCVREGNRSALCSSLHAYATACQDAQIGLASWRSATNC 986
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 911-987 1.08e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 85.08  E-value: 1.08e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1077060234   911 LYQSPWMCGNINDPgNSSFLACHSVVNPSPFFRNCLYNMCVREGNRSALCSSLHAYATACQDAQIGLASWRSATNCP 987
Cdd:smart00832    1 KYYACSQCGILLSP-RGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1338-1412 1.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 84.70  E-value: 1.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  1338 EPEAVRLCGLIVDRGGAFARCHSKVAPAFFYQSCLQDTCLDQGAQDTICNWLQVYASTCQAQGVPVTGWRSDTPC 1412
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1344-1412 2.67e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 83.58  E-value: 2.67e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234 1344 LCGLIVDrGGAFARCHSKVAPAFFYQSCLQDTCLDQGAQDTICNWLQVYASTCQAQGVPVTGWRSDTPC 1412
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 990-1044 2.10e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.96  E-value: 2.10e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  990 CPDNSHFEECTSACPLTCTNLDEPeEPCPLPCQEGCQCEDGFAL-RDGLCVARSDC 1044
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAP-PPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 596-649 2.36e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.36e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  596 CPEFSQYQVCTSACPASCSDLTSPLYCVHPCTEGCQCDPGYVLS-GSRCVQQDDC 649
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 596-649 3.97e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.19  E-value: 3.97e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  596 CPEFSQYQVCTSACPASCSDLTSPLYCVHPCTEGCQCDPGYVLS-GSRCVQQDDC 649
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 990-1044 1.65e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 69.72  E-value: 1.65e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  990 CPDNSHFEECTSACPLTCTNLdEPEEPCPLPCQEGCQCEDGFALR-DGLCVARSDC 1044
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANL-SPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1416-1469 9.83e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 67.34  E-value: 9.83e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1416 CPPNSHYSSCVSVCPPQCAPARGQRDCNQDCTEGCQCDQGYVLN-GKSCILSQNC 1469
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1724-1795 8.36e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 65.44  E-value: 8.36e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234  1724 QGEDACQKLTQLKGFFQPCHGLLDPRPFYQSCYLDGC-YNHRKAQVCGSLAAYAEACRSLGTLTTKWIAQENC 1795
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1416-1469 1.72e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 63.95  E-value: 1.72e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1416 CPPNSHYSSCVSVCPPQCAPARGQRDCNQDCTEGCQCDQGYVLN-GKSCILSQNC 1469
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1098-1256 5.54e-12

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 65.89  E-value: 5.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1098 YFCQPRTEALCVVAGYGHFLPFGGVPFELQSSCTlrmaTSVCRrggrentlTSGTFPQFKLAARNEERDTGQAiWLRGFV 1177
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCY----YVLAQ--------DCSSEPTFSVLLKNVPCGGGAT-CLKSVK 68

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1178 LEVYEYEIEVSRSyRNTVTVNKERLYLPLKLGLGKVNIFTSGMMLILETDFGL-KAAFDWNTLLLLTLPRDLYNTSCGLC 1256
Cdd:smart00216   69 VELNGDEIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLC 147
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1108-1256 4.03e-11

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 63.16  E-value: 4.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1108 CVVAGYGHFLPFGGVPFELQSSCTLRMATsvcrrggrenTLTSGTFPQFkLAARNEERDTGQAIWLRGFVLEVYEYEIEV 1187
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAK----------DCSEEPDFSF-SVTNKNCNGGASGVCLKSVTVIVGDLEITL 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1188 SRsyRNTVTVNKERLYLPLKLGLGKVNIFTSGM-MLILETDFGLKAAFDWNTLLLLTLPRDLYNTSCGLC 1256
Cdd:pfam00094   70 QK--GGTVLVNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLC 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1729-1795 2.20e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.16  E-value: 2.20e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234 1729 CQKLTQlKGFFQPCHGLLDPRPFYQSCYLDGC-YNHRKAQVCGSLAAYAEACRSLGTLTTKWIAQENC 1795
Cdd:pfam08742    2 CGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2126-2160 7.87e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 7.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1077060234 2126 CEDDNGGCEQICTSKGTGPICSCVTG-MLQPDGQSC 2160
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1471-1524 3.96e-05

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 43.06  E-value: 3.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1077060234 1471 CYTDGKYYEPKQLFWNSDCTKRCQCIGrNLVQCDPRRCKAEEECTLRHGVRGCF 1524
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
1471-1526 3.88e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 40.62  E-value: 3.88e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  1471 CYTDGKYYEPkQLFWNSDCTkRCQCIGRNLVqCDPRRCKAeEECTLRHGVRGCFAR 1526
Cdd:smart00215    1 CWNNGSYYPP-GAKWDDDCN-RCTCLNGRVS-CTKVWCGP-KPCLLHNLSGECPLG 52
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 261-316 7.89e-03

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 36.51  E-value: 7.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  261 CSHNGRYYRRGEiFWLSDQCSQRCRCLdiNNEVQCLEAPCGQFENCEQQEGAFFCQ 316
Cdd:pfam12714    2 KDAQGNYIPAGK-TWFSSGCTQSCTCT--GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1845-2096 3.10e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 187.81  E-value: 3.10e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1845 CKHAQMEVSISKCKLFQLGFEREDVR--VNDERCAG---IEGEDFISFHINNTkgHCGSIVQSNGTHIMYKNTVWIESVN 1919
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1920 NtGNVITRDKTINVEFSCAYELDLKISLETVLKPMLSVINltlPTQEGNFITKMALYKNSSYRNPYREGEVVLSTRDILF 1999
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPPSPVPIT---VSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 2000 VGVFVEGADENQLILIVNMCWATPSRYSSDRLRYIIIERGCPNTKDNTIG--MAENGVSLTCRFHVTVFKFIGDY-DEVH 2076
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1077060234 2077 LHCDVSLCDSDTNACKVNCP 2096
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1845-2096 5.45e-53

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 187.21  E-value: 5.45e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1845 CKHAQMEVSISKCKLFQLGFEREDVRVNDERCAG---IEGEDFISFHINNTKghCGSIVQSNGTHIMYKNTVWIESVNNt 1921
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSPFHP- 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1922 gNVITRDKTINVEFSCAYELDLKISLETVLKPMLSVINLtlPTQEGNFITKMALYKNSSYRNPYREGEVVLstRDILFVG 2001
Cdd:smart00241   79 -GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELS--SVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYHE 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  2002 VFVEGADENQLILIVNMCWATPSRYSSDRLRYIIIERGCPNTKDNTIGMA-ENGVSLTCRFHVTVFKFIgDYDEVHLHCD 2080
Cdd:smart00241  154 WECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPyNSNPLHRARFSVKVFKFA-DRSLVYFHCQ 232

                           250
                    ....*....|....*...
gi 1077060234  2081 VSLCDSDTNA--CKVNCP 2096
Cdd:smart00241  233 IRLCDKDDGSscDGPACS 250
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
99-251 3.66e-52

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 180.70  E-value: 3.66e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234    99 PLWADVHNGIRGDVYYRETTDPELLERATQDVQKYFKNMPTFTASWVFIATWHQVTFYGGSQTTPVNTFQTVLISDGVVS 178
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234   179 YSMFNYGEITWSTGTASGGDPltglgGTTAQAGFNGGDIGHFFNLPGSRSNDVVNIEQTTNVNVPGRWFFRVD 251
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVD 148
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 323-479 4.78e-45

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 160.61  E-value: 4.78e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  323 CVVFGDPHYHTFDGFLYHFQGTCSYLLARPCWEmLGLPFFSVEAKNENRGvASVSWLRDVTVEVYGHRVMIPKGslGTVQ 402
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSE-EPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234  403 VDGLVKTLPVQLQLGAVKVYQSGVA-VALETDFGLLVTYDGQHYASISLPSSYFNNTCGLCGNYNDDPADDPVLPDGS 479
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 314-478 1.31e-44

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 159.49  E-value: 1.31e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   314 FCQPTRtSTCVVFGDPHYHTFDGFLYHFQGTCSYLLARPCWEmlgLPFFSVEAKNENRGvASVSWLRDVTVEVYGHrVMI 393
Cdd:smart00216    4 TQEECS-PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS---EPTFSVLLKNVPCG-GGATCLKSVKVELNGD-EIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   394 PKGSLGTVQVDGLVKTLPVQLQLGAVKVYQSGVAVALETDFGLL-VTYDGQHYASISLPSSYFNNTCGLCGNYNDDPADD 472
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDD 157


                    ....*.
gi 1077060234   473 PVLPDG 478
Cdd:smart00216  158 FRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 164-252 3.31e-37

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 135.50  E-value: 3.31e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  164 VNTFQTVLISDGVVSYSMFNYGE--ITWSTGTASGGdpLTGLGGTTAQAGFNGGD-IGHFFNLPGSRSNDVVNIEQTTNV 240
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDggIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1077060234  241 NVPGRWFFRVDT 252
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1531-1682 1.20e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 130.57  E-value: 1.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1531 CVASGGGVFRTFDGASLRLPASCSFVLSTNCHKLPDLSFQLIANFDKWSTPNLTTIShVYLYINEENI-LISGSTVKVNG 1609
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVCLKS-VTVIVGDLEItLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1610 TPVSVPFLTGLMTRLSTSEGFIVIDTPQDIQVRYNR--FNTLSITMGQRLQNKVCGLCGNFNGDPSDDYITSRGK 1682
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGdgRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1521-1681 7.88e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.90  E-value: 7.88e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1521 RGCFARRSQH-CVASGGGVFRTFDGASLRLPASCSFVLSTNCHKLPDLSFqLIANFDkwSTPNLTTISHVYLYINEENIL 1599
Cdd:smart00216    1 WCCTQEECSPtCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFSV-LLKNVP--CGGGATCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1600 ISGS--TVKVNGTPVSVPFLTGLMT-RLSTSEGFIVIDTPQDI-QVRYNRFNTLSITMGQRLQNKVCGLCGNFNGDPSDD 1675
Cdd:smart00216   78 LKDDngKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDD 157


                    ....*.
gi 1077060234  1676 YITSRG 1681
Cdd:smart00216  158 FRTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 518-593 1.07e-29

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 113.59  E-value: 1.07e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234   518 TYFRSDYCGLINKTDGPFRDCRAVVDPTAFVYSCVYDMCSYRDNMTTLCHAIQAYALACQALGVTIRPWRTRTFCP 593
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 524-592 2.79e-22

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 92.06  E-value: 2.79e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234  524 YCGLINKtDGPFRDCRAVVDPTAFVYSCVYDMCSYRDNMTTLCHAIQAYALACQALGVTIRPWRTRTFC 592
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 715-873 6.97e-22

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 6.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234   715 GVCSVTQTSIASSFDGTFLLFPDDSSYYLLKLCGPTPAngsvVEVKIGRRLMNKGPVWKRPVIVTVANLEAQVGGSDfDT 794
Cdd:smart00216   10 PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPT----FSVLLKNVPCGGGATCLKSVKVELNGDEIELKDDN-GK 84

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234   795 VKVNGEPVVLPFVHPMETMMIYKAPGNATVVESRGLLRVQYTRQGFLNISLSTIFYNVTCGLCGVFNSNVTDDLRLPNG 873
Cdd:smart00216   85 VTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 717-874 1.13e-21

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 93.59  E-value: 1.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  717 CSVTQTSIASSFDGTFLLFPDDSSYYLLKLCGPTPANGSVVEVKIGRRlmNKGPVWKRPVIVTVANLEAQVGgsDFDTVK 796
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNG--GASGVCLKSVTVIVGDLEITLQ--KGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234  797 VNGEPVVLPFVHPMETMMIYKAPGNATVVESRGLLRVQYTRQGFLNISLSTIFYNVTCGLCGVFNSNVTDDLRLPNGR 874
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 917-986 1.01e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 84.74  E-value: 1.01e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  917 MCGNINDpgNSSFLACHSVVNPSPFFRNCLYNMCVREGNRSALCSSLHAYATACQDAQIGLASWRSATNC 986
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 911-987 1.08e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 85.08  E-value: 1.08e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1077060234   911 LYQSPWMCGNINDPgNSSFLACHSVVNPSPFFRNCLYNMCVREGNRSALCSSLHAYATACQDAQIGLASWRSATNCP 987
Cdd:smart00832    1 KYYACSQCGILLSP-RGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1338-1412 1.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 84.70  E-value: 1.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  1338 EPEAVRLCGLIVDRGGAFARCHSKVAPAFFYQSCLQDTCLDQGAQDTICNWLQVYASTCQAQGVPVTGWRSDTPC 1412
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1344-1412 2.67e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 83.58  E-value: 2.67e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1077060234 1344 LCGLIVDrGGAFARCHSKVAPAFFYQSCLQDTCLDQGAQDTICNWLQVYASTCQAQGVPVTGWRSDTPC 1412
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 990-1044 2.10e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.96  E-value: 2.10e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  990 CPDNSHFEECTSACPLTCTNLDEPeEPCPLPCQEGCQCEDGFAL-RDGLCVARSDC 1044
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAP-PPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 596-649 2.36e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.36e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  596 CPEFSQYQVCTSACPASCSDLTSPLYCVHPCTEGCQCDPGYVLS-GSRCVQQDDC 649
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 596-649 3.97e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.19  E-value: 3.97e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234  596 CPEFSQYQVCTSACPASCSDLTSPLYCVHPCTEGCQCDPGYVLS-GSRCVQQDDC 649
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 990-1044 1.65e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 69.72  E-value: 1.65e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  990 CPDNSHFEECTSACPLTCTNLdEPEEPCPLPCQEGCQCEDGFALR-DGLCVARSDC 1044
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANL-SPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1416-1469 9.83e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 67.34  E-value: 9.83e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1416 CPPNSHYSSCVSVCPPQCAPARGQRDCNQDCTEGCQCDQGYVLN-GKSCILSQNC 1469
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1724-1795 8.36e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 65.44  E-value: 8.36e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1077060234  1724 QGEDACQKLTQLKGFFQPCHGLLDPRPFYQSCYLDGC-YNHRKAQVCGSLAAYAEACRSLGTLTTKWIAQENC 1795
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1416-1469 1.72e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 63.95  E-value: 1.72e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1077060234 1416 CPPNSHYSSCVSVCPPQCAPARGQRDCNQDCTEGCQCDQGYVLN-GKSCILSQNC 1469
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1098-1256 5.54e-12

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 65.89  E-value: 5.54e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1098 YFCQPRTEALCVVAGYGHFLPFGGVPFELQSSCTlrmaTSVCRrggrentlTSGTFPQFKLAARNEERDTGQAiWLRGFV 1177
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCY----YVLAQ--------DCSSEPTFSVLLKNVPCGGGAT-CLKSVK 68

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234  1178 LEVYEYEIEVSRSyRNTVTVNKERLYLPLKLGLGKVNIFTSGMMLILETDFGL-KAAFDWNTLLLLTLPRDLYNTSCGLC 1256
Cdd:smart00216   69 VELNGDEIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLC 147
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1108-1256 4.03e-11

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 63.16  E-value: 4.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1108 CVVAGYGHFLPFGGVPFELQSSCTLRMATsvcrrggrenTLTSGTFPQFkLAARNEERDTGQAIWLRGFVLEVYEYEIEV 1187
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAK----------DCSEEPDFSF-SVTNKNCNGGASGVCLKSVTVIVGDLEITL 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1077060234 1188 SRsyRNTVTVNKERLYLPLKLGLGKVNIFTSGM-MLILETDFGLKAAFDWNTLLLLTLPRDLYNTSCGLC 1256
Cdd:pfam00094   70 QK--GGTVLVNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLC 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1729-1795 2.20e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.16  E-value: 2.20e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1077060234 1729 CQKLTQlKGFFQPCHGLLDPRPFYQSCYLDGC-YNHRKAQVCGSLAAYAEACRSLGTLTTKWIAQENC 1795
Cdd:pfam08742    2 CGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2126-2160 7.87e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 7.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1077060234 2126 CEDDNGGCEQICTSKGTGPICSCVTG-MLQPDGQSC 2160
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1471-1524 3.96e-05

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 43.06  E-value: 3.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1077060234 1471 CYTDGKYYEPKQLFWNSDCTKRCQCIGrNLVQCDPRRCKAEEECTLRHGVRGCF 1524
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
1471-1526 3.88e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 40.62  E-value: 3.88e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  1471 CYTDGKYYEPkQLFWNSDCTkRCQCIGRNLVqCDPRRCKAeEECTLRHGVRGCFAR 1526
Cdd:smart00215    1 CWNNGSYYPP-GAKWDDDCN-RCTCLNGRVS-CTKVWCGP-KPCLLHNLSGECPLG 52
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 261-316 7.89e-03

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 36.51  E-value: 7.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1077060234  261 CSHNGRYYRRGEiFWLSDQCSQRCRCLdiNNEVQCLEAPCGQFENCEQQEGAFFCQ 316
Cdd:pfam12714    2 KDAQGNYIPAGK-TWFSSGCTQSCTCT--GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH