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Conserved domains on  [gi|1067578915|emb|SBN07355|]
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glycosyl transferase family protein [Neisseria gonorrhoeae]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 11-114 7.03e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06433:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 202  Bit Score: 45.23  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067578915  11 GAWLEVLSEENNKSVLAAIARNGAIWDKPTRHEDIVAVFPF-------GNPIHNNTMIMRRSVIDGGLRFDPAYIHAEDY 83
Cdd:cd06433    91 GALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFldkfllyGMPICHQATFFRRSLFEKYGGFDESYRIAADY 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1067578915  84 KFWYEAGKLGRL-AYYPEALVKYRFHQDQTSS 114
Cdd:cd06433   171 DLLLRLLLAGKIfKYLPEVLAAFRLGGVSSTS 202
 
Name Accession Description Interval E-value
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 11-114 7.03e-06

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 45.23  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067578915  11 GAWLEVLSEENNKSVLAAIARNGAIWDKPTRHEDIVAVFPF-------GNPIHNNTMIMRRSVIDGGLRFDPAYIHAEDY 83
Cdd:cd06433    91 GALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFldkfllyGMPICHQATFFRRSLFEKYGGFDESYRIAADY 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1067578915  84 KFWYEAGKLGRL-AYYPEALVKYRFHQDQTSS 114
Cdd:cd06433   171 DLLLRLLLAGKIfKYLPEVLAAFRLGGVSSTS 202
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 54-125 1.75e-04

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 41.20  E-value: 1.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1067578915  54 PIHNNTMIMRRSVIDGGLRFDPAYIHAEDYKFWYEAGKLG-RLAYYPEALVKyrfHQDQTSSKYNLQQrRTAW 125
Cdd:pfam13641 159 PLSGAGSAIRREVLKELGLFDPFFLLGDDKSLGRRLRRHGwRVAYAPDAAVR---TVFPTYLAASIKQ-RARW 227
 
Name Accession Description Interval E-value
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 11-114 7.03e-06

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 45.23  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067578915  11 GAWLEVLSEENNKSVLAAIARNGAIWDKPTRHEDIVAVFPF-------GNPIHNNTMIMRRSVIDGGLRFDPAYIHAEDY 83
Cdd:cd06433    91 GALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFldkfllyGMPICHQATFFRRSLFEKYGGFDESYRIAADY 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1067578915  84 KFWYEAGKLGRL-AYYPEALVKYRFHQDQTSS 114
Cdd:cd06433   171 DLLLRLLLAGKIfKYLPEVLAAFRLGGVSSTS 202
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 54-125 1.75e-04

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 41.20  E-value: 1.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1067578915  54 PIHNNTMIMRRSVIDGGLRFDPAYIHAEDYKFWYEAGKLG-RLAYYPEALVKyrfHQDQTSSKYNLQQrRTAW 125
Cdd:pfam13641 159 PLSGAGSAIRREVLKELGLFDPFFLLGDDKSLGRRLRRHGwRVAYAPDAAVR---TVFPTYLAASIKQ-RARW 227
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 58-110 4.72e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 39.92  E-value: 4.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1067578915  58 NTMIMRRSVIDGGLRFDPAYIHAEDYKFWYEAGKLGRLAYYPEALVKYRFHQD 110
Cdd:cd04196   155 CTMAFNRELLELALPFPDADVIMHDWWLALLASAFGKVVFLDEPLILYRQHGN 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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