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Conserved domains on  [gi|1067579109|emb|SBN03497|]
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putative phage associated protein [Neisseria gonorrhoeae]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10650117)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRE super family cl43426
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
18-49 4.30e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


The actual alignment was detected with superfamily member COG1476:

Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 4.30e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE 49
Cdd:COG1476    8 RLKELRKERGLTQEELAELLGV-SRQTISAIE 38
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
18-49 4.30e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 4.30e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE 49
Cdd:COG1476    8 RLKELRKERGLTQEELAELLGV-SRQTISAIE 38
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
18-56 1.40e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.26  E-value: 1.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1067579109  18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE---AEPDTET 56
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGV-SRSTLSRIEngkRKPSLET 41
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 18-56 3.23e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.53  E-value: 3.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVKHYiQVGRWE---AEPDTET 56
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRS-TISRIEngkRNPSLET 43
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
18-49 4.30e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 4.30e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE 49
Cdd:COG1476    8 RLKELRKERGLTQEELAELLGV-SRQTISAIE 38
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
18-56 1.20e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 34.20  E-value: 1.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE---AEPDTET 56
Cdd:COG1396   11 RLRELRKARGLTQEELAERLGV-SRSTISRIErgrRNPSLET 51
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
18-56 1.40e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.26  E-value: 1.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1067579109  18 NLRTLRNRCKLTQAELAQIVGVkHYIQVGRWE---AEPDTET 56
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGV-SRSTLSRIEngkRKPSLET 41
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 18-56 3.23e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.53  E-value: 3.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1067579109 18 NLRTLRNRCKLTQAELAQIVGVKHYiQVGRWE---AEPDTET 56
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRS-TISRIEngkRNPSLET 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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