NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1067579096|emb|SBN03269|]
View 

putative phage associated protein [Neisseria gonorrhoeae]

Protein Classification

type II toxin-antitoxin system HicB family antitoxin( domain architecture ID 581201)

type II toxin-antitoxin system HicB family antitoxin is the antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin preventing effects of the cognate HicA family toxin

Gene Ontology:  GO:0110001
PubMed:  30337369|16895922|28279904
SCOP:  4001747

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HicB_lk_antitox super family cl23837
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 4-122 8.49e-35

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


The actual alignment was detected with superfamily member pfam15919:

Pssm-ID: 451570 [Multi-domain]  Cd Length: 123  Bit Score: 116.59  E-value: 8.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067579096   4 YPAVLFQDpDQSNWGVIIPDLPGCYPVGDTVADALADAKAAAMFHLEGLLQENLPIPEAQSIEVNRDNPDYADAVlWTMV 83
Cdd:pfam15919   1 YPIAIEKD-EDSAYGVVVPDLPGCFSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAGWI-WALV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1067579096  84 EADDAALTGQ-VRFNVSWPQHILNRVDACTAARHETRAVF 122
Cdd:pfam15919  79 DIDLSPLDGKsERINITLPRRVLRRIDAYAKAAGETRSGF 118
 
Name Accession Description Interval E-value
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 4-122 8.49e-35

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 116.59  E-value: 8.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067579096   4 YPAVLFQDpDQSNWGVIIPDLPGCYPVGDTVADALADAKAAAMFHLEGLLQENLPIPEAQSIEVNRDNPDYADAVlWTMV 83
Cdd:pfam15919   1 YPIAIEKD-EDSAYGVVVPDLPGCFSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAGWI-WALV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1067579096  84 EADDAALTGQ-VRFNVSWPQHILNRVDACTAARHETRAVF 122
Cdd:pfam15919  79 DIDLSPLDGKsERINITLPRRVLRRIDAYAKAAGETRSGF 118
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
4-68 9.69e-10

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 51.04  E-value: 9.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1067579096   4 YPAVLFQDPDQSnWGVIIPDLPGCYPVGDTVADALADAKAAAMFHLEGLLQENLPIPEAQSIEVN 68
Cdd:COG1598     2 YPAIIEKDEDGG-YVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSIEET 65
 
Name Accession Description Interval E-value
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 4-122 8.49e-35

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 116.59  E-value: 8.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1067579096   4 YPAVLFQDpDQSNWGVIIPDLPGCYPVGDTVADALADAKAAAMFHLEGLLQENLPIPEAQSIEVNRDNPDYADAVlWTMV 83
Cdd:pfam15919   1 YPIAIEKD-EDSAYGVVVPDLPGCFSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAGWI-WALV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1067579096  84 EADDAALTGQ-VRFNVSWPQHILNRVDACTAARHETRAVF 122
Cdd:pfam15919  79 DIDLSPLDGKsERINITLPRRVLRRIDAYAKAAGETRSGF 118
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
4-68 9.69e-10

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 51.04  E-value: 9.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1067579096   4 YPAVLFQDPDQSnWGVIIPDLPGCYPVGDTVADALADAKAAAMFHLEGLLQENLPIPEAQSIEVN 68
Cdd:COG1598     2 YPAIIEKDEDGG-YVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSIEET 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH