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Conserved domains on  [gi|1544895672|gb|RUJ83209|]
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protein-L-isoaspartate(D-aspartate) O-methyltransferase [Pseudomonas aeruginosa]

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 10011370)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091
PubMed:  1860862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-211 1.10e-119

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


:

Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 338.33  E-value: 1.10e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDK 80
Cdd:PRK00312    3 LMESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELL-ELKPGDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  81 VMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSL 160
Cdd:PRK00312   82 VLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRAL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544895672 161 LDQLAPGGRLVIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNGPIA 211
Cdd:PRK00312  162 LEQLKEGGILVAPVGGEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-211 1.10e-119

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 338.33  E-value: 1.10e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDK 80
Cdd:PRK00312    3 LMESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELL-ELKPGDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  81 VMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSL 160
Cdd:PRK00312   82 VLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRAL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544895672 161 LDQLAPGGRLVIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNGPIA 211
Cdd:PRK00312  162 LEQLKEGGILVAPVGGEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 11-208 2.93e-109

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 311.25  E-value: 2.93e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  11 IQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDKVMEIGTGSGY 90
Cdd:COG2518     1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEAL-DLKPGDRVLEIGTGSGY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  91 QTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSLLDQLAPGGRL 170
Cdd:COG2518    80 QAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRL 159

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1544895672 171 VIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNG 208
Cdd:COG2518   160 VAPVGEGGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
5-205 3.15e-75

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 225.33  E-value: 3.15e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   5 RTRERLIQRLYEEG-LSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELL-LAAGplDKVM 82
Cdd:pfam01135   1 NRNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLeLKPG--MRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  83 EIGTGSGYQTAVLAQLVERVF---SVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQS 159
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGrvvSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1544895672 160 LLDQLAPGGRLVIPVGGGEVQQLMLIVRTEDG-FSRQVLDSVRFVPL 205
Cdd:pfam01135 159 LIDQLKEGGRLVIPVGPNGNQVLQQFDKRNDGsVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-208 1.08e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 224.32  E-value: 1.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLsNAH--VLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPL 78
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGY-IKSkrVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELL-ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  79 DKVMEIGTGSGYQTAVLAQLVER---VFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATE 155
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRdglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPK 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1544895672 156 VPQSLLDQLAPGGRLVIPVGGGEvQQLMLIVRTEDGFSRQVLDSVRFVPLLNG 208
Cdd:TIGR00080 159 IPEALIDQLKEGGILVMPVGEYL-QVLKRAEKRGGEIIIKDVEPVAFVPLVGG 210
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-174 1.70e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQL-VERVFSVERIQALQDKAKERLAELNLRNVVFRWGDgWEGWSALAP--YNGIIVTAAATEV 156
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGD-AEELPPEADesFDVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....*
gi 1544895672 157 PQS-------LLDQLAPGGRLVIPV 174
Cdd:cd02440    80 VEDlarfleeARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
1-211 1.10e-119

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 338.33  E-value: 1.10e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDK 80
Cdd:PRK00312    3 LMESERFARLVLRLRAEGILDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELL-ELKPGDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  81 VMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSL 160
Cdd:PRK00312   82 VLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPRAL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1544895672 161 LDQLAPGGRLVIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNGPIA 211
Cdd:PRK00312  162 LEQLKEGGILVAPVGGEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 11-208 2.93e-109

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 311.25  E-value: 2.93e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  11 IQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDKVMEIGTGSGY 90
Cdd:COG2518     1 VQQLRPRGVTDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEAL-DLKPGDRVLEIGTGSGY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  91 QTAVLAQLVERVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQSLLDQLAPGGRL 170
Cdd:COG2518    80 QAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGRL 159

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1544895672 171 VIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLLNG 208
Cdd:COG2518   160 VAPVGEGGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
5-205 3.15e-75

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 225.33  E-value: 3.15e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   5 RTRERLIQRLYEEG-LSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELL-LAAGplDKVM 82
Cdd:pfam01135   1 NRNEALIENLKNYGvIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLeLKPG--MRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  83 EIGTGSGYQTAVLAQLVERVF---SVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQS 159
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGrvvSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1544895672 160 LLDQLAPGGRLVIPVGGGEVQQLMLIVRTEDG-FSRQVLDSVRFVPL 205
Cdd:pfam01135 159 LIDQLKEGGRLVIPVGPNGNQVLQQFDKRNDGsVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 1-208 1.08e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 224.32  E-value: 1.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLsNAH--VLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPL 78
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGY-IKSkrVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELL-ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  79 DKVMEIGTGSGYQTAVLAQLVER---VFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATE 155
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRdglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPK 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1544895672 156 VPQSLLDQLAPGGRLVIPVGGGEvQQLMLIVRTEDGFSRQVLDSVRFVPLLNG 208
Cdd:TIGR00080 159 IPEALIDQLKEGGILVMPVGEYL-QVLKRAEKRGGEIIIKDVEPVAFVPLVGG 210
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 1-206 4.77e-66

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 202.17  E-value: 4.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   1 MTSQRTRERLIQRLYEEGLSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELL-LAAGplD 79
Cdd:PRK13942    1 MPLEEKRRVIEELIREGYIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLdLKEG--M 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQLVER---VFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEV 156
Cdd:PRK13942   79 KVLEIGTGSGYHAAVVAEIVGKsgkVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDI 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1544895672 157 PQSLLDQLAPGGRLVIPVgGGEVQQLMLIVRTEDGFSRQVLDSVRFVPLL 206
Cdd:PRK13942  159 PKPLIEQLKDGGIMVIPV-GSYSQELIRVEKDNGKIIKKKLGEVAFVPLI 207
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 7-205 5.54e-41

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 138.41  E-value: 5.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   7 RERLIQRLYEEG-LSNAHVLEVIRRTPRHLFVDEALSHRAYEDTALPIGHNQTISQPFMVARMTELLlAAGPLDKVMEIG 85
Cdd:PRK13944    2 AKRLVEELVREGiIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELI-EPRPGMKILEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  86 TGSGYQTAVLAQLVER---VFSVERIQALQDKAKERLAELNLRNVVFRW-GDGWEGWSALAPYNGIIVTAAATEVPQSLL 161
Cdd:PRK13944   81 TGSGYQAAVCAEAIERrgkVYTVEIVKELAIYAAQNIERLGYWGVVEVYhGDGKRGLEKHAPFDAIIVTAAASTIPSALV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1544895672 162 DQLAPGGRLVIPVGGGEVQQLMLIVRTEDGFSRQVLDSVRFVPL 205
Cdd:PRK13944  161 RQLKDGGVLVIPVEEGVGQVLYKVVKRGEKVEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 5-174 1.63e-28

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 110.15  E-value: 1.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   5 RTRERLIQRLYEEG-LSNAHVLEVIRRTPRHLFVDEALSHRAYE-DTALPIGHNQT------ISQPFMVARMTELLlAAG 76
Cdd:TIGR04364   3 RLRAALVDELREDGvIRSPRVEAAFRTVPRHLFAPGAPLEKAYAaNRAVVTKRDEDgralssVSAPHIQAMMLEQA-GVE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  77 PLDKVMEIGTGsGYQTAVLAQLVE---RVFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAA 153
Cdd:TIGR04364  82 PGMRVLEIGSG-GYNAALLAELVGpsgEVTTVDIDEDVTDRARACLAAAGYPQVTVVLADAEAGVPELAPYDRIIVTVGA 160

                         170       180
                  ....*....|....*....|.
gi 1544895672 154 TEVPQSLLDQLAPGGRLVIPV 174
Cdd:TIGR04364 161 WDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 7-203 2.56e-26

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 103.00  E-value: 2.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672   7 RERLIQRLYEEGLSNaHVLEVIRRTPRHLFVDEA--LSHrAYEDTALPIGHNQ----TISQPFMVARMTELL-LAAGPld 79
Cdd:PRK13943    7 REKLFWILKKYGISD-HIAKAFLEVPREEFLTKSypLSY-VYEDIVLVSYDDGeeysTSSQPSLMALFMEWVgLDKGM-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQLVER---VFSVERIQALQDKAKERLAELNLRNVVFRWGDGWEGWSALAPYNGIIVTAAATEV 156
Cdd:PRK13943   83 RVLEIGGGTGYNAAVMSRVVGEkglVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEV 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1544895672 157 PQSLLDQLAPGGRLVIPVGG--GEVQQLMLIVRTEDGFSRQVLDSVRFV 203
Cdd:PRK13943  163 PETWFTQLKEGGRVIVPINLklSRRQPAFLFKKKDPYLVGNYKLETRFI 211
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 10-191 5.04e-22

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 92.04  E-value: 5.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  10 LIQRLYEEG-LSNAHVLEVIRRTPRHLFV-----------------------DEALSHrAYEDTALPIGHNQTI------ 59
Cdd:TIGR04188   1 LAARLAAAGvLTDPAWREAVEAVPRHLFLpgfftqlpdgrgwrpvtadrpdpDEWLAL-VYSDETLVTQLDGDLaadaag 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  60 -----------SQPFMVARMTELL-LAAGPldKVMEIGTGSGYQTAVLAQLV--ERVFSVERIQALQDKAKERLAELNLR 125
Cdd:TIGR04188  80 gpvtgrptsssTQPSLVARMLEALdVEDGH--RVLEIGTGTGYSAALLCHRLgdDNVTSVEVDPGLAARAASALAAAGYA 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1544895672 126 NVVFRwGDGWEGWSALAPYNGIIVTAAATEVPQSLLDQLAPGGRLVIPVGGGEVQQLMLIVR-TEDG 191
Cdd:TIGR04188 158 PTVVT-GDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSGWLYGGGLVRLTvDDDG 223
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 72-193 9.30e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.53  E-value: 9.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  72 LLAAGPLDKVMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLrNVVFRWGDGWEGWSALAPYNGIIVTA 151
Cdd:COG2226    17 ALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSFDLVISSF 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1544895672 152 AATEVP------QSLLDQLAPGGRLVI----PVGGGEVQQLMlivrTEDGFS 193
Cdd:COG2226    96 VLHHLPdperalAEIARVLKPGGRLVVvdfsPPDLAELEELL----AEAGFE 143
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 56-172 1.01e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.16  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  56 NQTISQPFMVARMTELLLAAGPLDK-VMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNLRnvvFRWGDG 134
Cdd:COG2227     2 SDPDARDFWDRRLAALLARLLPAGGrVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVD---FVQGDL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1544895672 135 WEGWSALAPYNGIIVTAAATEVP------QSLLDQLAPGGRLVI 172
Cdd:COG2227    79 EDLPLEDGSFDLVICSEVLEHLPdpaallRELARLLKPGGLLLL 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-174 1.70e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQL-VERVFSVERIQALQDKAKERLAELNLRNVVFRWGDgWEGWSALAP--YNGIIVTAAATEV 156
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGD-AEELPPEADesFDVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....*
gi 1544895672 157 PQS-------LLDQLAPGGRLVIPV 174
Cdd:cd02440    80 VEDlarfleeARRLLKPGGVLVLTL 104
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
81-172 3.82e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  81 VMEIGTGSGYQTAVLAQLVE--RVFSVERIQALQDKAKERLAelnlrNVVFRWGDgWEGWSALAPYNGIIVTAAATEVP- 157
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPgaRVTGVDLSPEMLARARARLP-----NVRFVVAD-LRDLDPPEPFDLVVSNAALHWLPd 78

                          90       100
                  ....*....|....*....|
gi 1544895672 158 -----QSLLDQLAPGGRLVI 172
Cdd:COG4106    79 haallARLAAALAPGGVLAV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 67-172 9.02e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.15  E-value: 9.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  67 RMTELLLAAGPL---DKVMEIGTGSGYQTAVLAQLVE-RVFSVERIQALQDKAKERLAELNLRNVV-FRWGDgWEGWSAL 141
Cdd:COG2230    38 AKLDLILRKLGLkpgMRVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARERAAEAGLADRVeVRLAD-YRDLPAD 116

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1544895672 142 APYNGIIVTAAATEVP--------QSLLDQLAPGGRLVI 172
Cdd:COG2230   117 GQFDAIVSIGMFEHVGpenypayfAKVARLLKPGGRLLL 155
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 76-172 9.23e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 45.15  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  76 GPLDKVMEIGTGSGYQTAVLAQLV---ERVFSVERIQALQDKAKERLAELNL-RNVVFRWGDGWEGWSA----------L 141
Cdd:COG2519    90 FPGARVLEAGTGSGALTLALARAVgpeGKVYSYERREDFAEIARKNLERFGLpDNVELKLGDIREGIDEgdvdavfldmP 169

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1544895672 142 APYNgiIVTAAAtevpqsllDQLAPGGRLVI 172
Cdd:COG2519   170 DPWE--ALEAVA--------KALKPGGVLVA 190
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 80-172 4.88e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.60  E-value: 4.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQL-VERVFSVERIQALQDKAKERLAELNLRNVVFRWGDgWEGWSAL--APYNGIIVTAAATEV 156
Cdd:COG0500    29 RVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD-LAELDPLpaESFDLVVAFGVLHHL 107

                          90       100
                  ....*....|....*....|....
gi 1544895672 157 P--------QSLLDQLAPGGRLVI 172
Cdd:COG0500   108 PpeereallRELARALKPGGVLLL 131
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-172 5.01e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 5.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  80 KVMEIGTGSGYQTAVLAQLVE---RVFSVERIQALQDKAKERLAELNLRNVVFRWGDgWE---GWSALAPYNGIIVTAAA 153
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKLGFDNVEFEQGD-IEelpELLEDDKFDVVISNCVL 84

                          90       100
                  ....*....|....*....|....*
gi 1544895672 154 TEVP------QSLLDQLAPGGRLVI 172
Cdd:pfam13847  85 NHIPdpdkvlQEILRVLKPGGRLII 109
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 69-172 6.40e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 42.10  E-value: 6.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  69 TELLLAAGPL---DKVMEIGTGSGYQTAVLAQLvervFSVERIQALqDK-------AKERLAELNLRNVVFRWGDGWEGW 138
Cdd:COG2813    38 TRLLLEHLPEplgGRVLDLGCGYGVIGLALAKR----NPEARVTLV-DVnaravelARANAAANGLENVEVLWSDGLSGV 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1544895672 139 SAlAPYNGIIV-------TAAATEVPQSLLDQ----LAPGGRLVI 172
Cdd:COG2813   113 PD-GSFDLILSnppfhagRAVDKEVAHALIADaarhLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 69-172 2.37e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  69 TELLLAAGPLD---KVMEIGTGSGYQTAVLAQL---VERVFSVERIQALqDKAKERLAELNLRNVVFRWGDGWEGWSAlA 142
Cdd:pfam05175  20 SRLLLEHLPKDlsgKVLDLGCGAGVLGAALAKEspdAELTMVDINARAL-ESARENLAANGLENGEVVASDVYSGVED-G 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1544895672 143 PYNGII-----------VTAAATEVPQSLLDQLAPGGRLVI 172
Cdd:pfam05175  98 KFDLIIsnppfhaglatTYNVAQRFIADAKRHLRPGGELWI 138
PRK08317 PRK08317
hypothetical protein; Provisional
 72-172 3.62e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 40.31  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  72 LLAAGPLDKVMEIGTGSGYQTAVLAQLVE---RVFSVERIQALQDKAKERLAElNLRNVVFRWGDGwegwSALaPYNGII 148
Cdd:PRK08317   14 LLAVQPGDRVLDVGCGPGNDARELARRVGpegRVVGIDRSEAMLALAKERAAG-LGPNVEFVRGDA----DGL-PFPDGS 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1544895672 149 VTAA-ATEV------PQSLLDQLA----PGGRLVI 172
Cdd:PRK08317   88 FDAVrSDRVlqhledPARALAEIArvlrPGGRVVV 122
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 71-134 1.44e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 37.86  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1544895672  71 LLLAAGPlDKVMEIGTGSGYQTAVLAQLVE---RVFSVERIQALQDKAKERLAELNLRNVV-FRWGDG 134
Cdd:COG4122    11 LARLLGA-KRILEIGTGTGYSTLWLARALPddgRLTTIEIDPERAAIARENFARAGLADRIrLILGDA 77
PRK14968 PRK14968
putative methyltransferase; Provisional
 69-106 1.60e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.96  E-value: 1.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1544895672  69 TELL---LAAGPLDKVMEIGTGSGYQTAVLAQLVERVFSVE 106
Cdd:PRK14968   12 SFLLaenAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVD 52
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 81-168 1.65e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.39  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544895672  81 VMEIGTGSGYQTAVLAQLVE-RVFSVERIQALQDKAKERLAELNLrNVVFRWGDGWEGWSALAPYNGIIVTAAATEVPQS 159
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 1544895672 160 LLDQ--------LAPGG 168
Cdd:pfam13649  80 DLEAalreiarvLKPGG 96
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
77-133 2.26e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 37.96  E-value: 2.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1544895672  77 PLDKVMEIGTGSGYQTAVLAQLVERVFSVERIQALQDKAKERLAELNlrNVVFRWGD 133
Cdd:PRK14896   29 DGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAG--NVEIIEGD 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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