|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
1-851 |
0e+00 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 1003.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:TIGR00915 1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SSSN-GSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATavQDVVRLNDYA 159
Cdd:TIGR00915 81 SSDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGS--MTKEDLSDYA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 160 ARVVNDEIRRVPGVGRVQFFGAEAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLGERPGAQDQELTTTLVVPG 239
Cdd:TIGR00915 159 ASNMVDPLSRLEGVGDVQLFGSQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPGQQLNATIIAQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:TIGR00915 239 RLQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:TIGR00915 319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:TIGR00915 399 VLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFLAPIDG---HQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVR 556
Cdd:TIGR00915 479 ALSVLVALILTPALCATMLKPIEKgehHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 557 LPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSmQEVTLVY---GFSFSGSGANAAMAFPSLRHWSER 633
Cdd:TIGR00915 559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEK-ANVESVFtvnGFSFAGRGQNMGMAFIRLKDWEER 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 634 SDSESAANEVAA-ANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQDRGNLGRDALMQAVNQLLRAANQSPKLAYAMV 712
Cdd:TIGR00915 638 TGKENSVFAIAGrATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVRP 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 713 EGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQ 792
Cdd:TIGR00915 718 NGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEM 797
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 1419931196 793 VPLTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAALPQGIGY 851
Cdd:TIGR00915 798 VPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQKLPPGFGF 856
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1-851 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 914.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:COG0841 3 LSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SSSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATAVQdvvrLNDYAA 160
Cdd:COG0841 83 TSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELE----LSDYAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 161 RVVNDEIRRVPGVGRVQFFGA-EAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLGerpgaqDQELTTTLVVPG 239
Cdd:COG0841 159 RNIKDRLERVPGVGQVQIFGGrEREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIG------GGDREYTVRTNG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQaNGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:COG0841 233 RLKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:COG0841 312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMaDEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:COG0841 392 VLAIGIVVDDAIVVVENIERHM-EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIAL 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFLAPIDgHQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRLPE 559
Cdd:COG0841 471 LISLFVALTLTPALCARLLKPHP-KGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPT 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 560 AFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTLVYGFSFSGSGANAAMAFPSLRHWSERSDSesa 639
Cdd:COG0841 550 EFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRS--- 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 640 ANEVAAA-NLALGRISDATIMaVMPPPIDGLGNSGGFSLRVQDRgnlGRDALMQAVNQLLRAANQSPKLAYAMVEGLADA 718
Cdd:COG0841 627 ADEIIARlREKLAKIPGARVF-VFQPPAGGLGSGAPIEVQLQGD---DLEELAAAAEKLLAALRQIPGLVDVRSDLQLGK 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 719 PQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQVPLTVF 798
Cdd:COG0841 703 PELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSV 782
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 1419931196 799 TTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAA--LPQGIGY 851
Cdd:COG0841 783 ATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAElkLPPGVSI 837
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
1-851 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 887.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:PRK09577 1 MARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SSSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATAvqDVVRLNDYAA 160
Cdd:PRK09577 81 TSSAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIQLIVSLTSDDGRL--TGVELGEYAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 161 RVVNDEIRRVPGVGRVQFFGAEAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLGERPGAQDQELTTTLVVPGL 240
Cdd:PRK09577 159 ANVLQALRRVEGVGKVQFWGAEYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAVPDSAPIAATVFADAP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 241 MESPQKFGQIVLRAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFPA 320
Cdd:PRK09577 239 LKTPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 321 DIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMV 400
Cdd:PRK09577 319 GVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 401 LAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSIL 480
Cdd:PRK09577 399 LAIGILVDDAIVVVENVERLMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 481 FSGFLALTMTPALCATFLAPIDG-HQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRLPE 559
Cdd:PRK09577 479 FSAFLALSLTPALCATLLKPVDGdHHEKRGFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPT 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 560 AFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTLVYGFSFSGSGANAAMAFPSLRHWSERSDSESA 639
Cdd:PRK09577 559 AFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEGPNGGMIFVTLKDWKERKAARDH 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 640 ANE-VAAANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQDRGNLGRDALMQAVNQLLRAANQSPKLAYAMVEGLADA 718
Cdd:PRK09577 639 VQAiVARINERFAGTPNTTVFAMNSPALPDLGSTSGFDFRLQDRGGLGYAAFVAAREQLLAEGAKDPALTDLMFAGTQDA 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 719 PQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQVPLTVF 798
Cdd:PRK09577 719 PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLAAF 798
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 1419931196 799 TTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAALPQGIGY 851
Cdd:PRK09577 799 ATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAATLPAGIGY 851
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
1-850 |
0e+00 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 845.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:PRK10555 1 MANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SSSN-GSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATavQDVVRLNDYA 159
Cdd:PRK10555 81 QSSGtGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGS--MDKQDIADYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 160 ARVVNDEIRRVPGVGRVQFFGAEAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLGERPGAQDQELTTTLVVPG 239
Cdd:PRK10555 159 ASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:PRK10555 239 LLQTPEQFRDITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:PRK10555 319 HGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:PRK10555 399 VLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFLAPIDG--HQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRL 557
Cdd:PRK10555 479 VLSVLVAMILTPALCATLLKPLKKgeHHGQKGFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 558 PEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYL--AARPSMQEVTLVYGFSFSGSGANAAMAFPSLRHWSERSD 635
Cdd:PRK10555 559 PTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYftHEKDNVMSVFATVGSGPGGNGQNVARMFIRLKDWDERDS 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 636 SE-SAANEVAAANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQDRGNLGRDALMQAVNQLLRAANQSPKLAYAMVEG 714
Cdd:PRK10555 639 KTgTSFAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAKNPELTRVRHNG 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 715 LADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQVP 794
Cdd:PRK10555 719 LDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVP 798
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 1419931196 795 LTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAALPQGIG 850
Cdd:PRK10555 799 FSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQLPNGFG 854
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1-851 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 837.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SSSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATAVQdvVRLNDYAA 160
Cdd:pfam00873 81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQ--TDLRDYAD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 161 RVVNDEIRRVPGVGRVQFFG-AEAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQELTTTLVVPG 239
Cdd:pfam00873 159 TNIKPQLSRVPGVGDVQLFGgSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQL------EGQGLQALIRAQG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQaNGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:pfam00873 233 QLQSAEDFEKIIVKNQ-DGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:pfam00873 312 QGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:pfam00873 392 VLAIGLVVDDAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFLAPIDgHQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRLPE 559
Cdd:pfam00873 472 LLSVLVALTLTPALCATLLKPRR-EPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPT 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 560 AFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTLVYGFSFSG--SGANAAMAFPSLRHWSERSDSE 637
Cdd:pfam00873 551 EFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSGdnNGPNSGDAFISLKPWKERPGPE 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 638 SAANE-VAAANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQD-RGNLGRDALMQAVNQLLRAANQSPKLAYAMVEGL 715
Cdd:pfam00873 631 KSVQAlIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVkIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQ 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 716 ADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQVPL 795
Cdd:pfam00873 711 EDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPL 790
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 1419931196 796 TVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAA--LPQGIGY 851
Cdd:pfam00873 791 SAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQvkLPPGYGY 848
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
1-851 |
0e+00 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 828.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 1 MSRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDS 80
Cdd:PRK15127 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 81 SS-SNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATAVQDvvRLNDYA 159
Cdd:PRK15127 81 NSdSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQE--DISDYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 160 ARVVNDEIRRVPGVGRVQFFGAEAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLGERPGAQDQELTTTLVVPG 239
Cdd:PRK15127 159 AANMKDPISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:PRK15127 239 RLTSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:PRK15127 319 SGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:PRK15127 399 VLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFLAPI---DGHQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYavLLGVLGLAY-- 554
Cdd:PRK15127 479 ALSVLVALILTPALCATMLKPIakgDHGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLY--LIIVVGMAYlf 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 555 VRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARP--SMQEVTLVYGFSFSGSGANAAMAFPSLRHWSE 632
Cdd:PRK15127 557 VRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEknNVESVFAVNGFGFAGRGQNTGIAFVSLKDWAD 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 633 RSDSESAANEVAA-ANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQDRGNLGRDALMQAVNQLLRAANQSPKLAYAM 711
Cdd:PRK15127 637 RPGEENKVEAITMrATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHPDMLVGV 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 712 -VEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTG 790
Cdd:PRK15127 717 rPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADG 796
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1419931196 791 RQVPLTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAALPQGIGY 851
Cdd:PRK15127 797 QMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASKLPTGVGY 857
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
2-849 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 553.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 2 SRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDSS 81
Cdd:NF033617 1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 82 SSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDAtavQDVVRLNDYAAR 161
Cdd:NF033617 81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEE---MPRGQLTDYAER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 162 VVNDEIRRVPGVGRVQFFGAE-AAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQELTTTLVVPGL 240
Cdd:NF033617 158 VLAPKLSQINGVGSVDVSGGQrPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAV------RGDSVVSTVRANDQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 241 MESPQKFGQIVLRAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFPA 320
Cdd:NF033617 232 LKTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 321 DIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMV 400
Cdd:NF033617 312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 401 LAIGILVDDAIVVVENVERLMaDEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSIL 480
Cdd:NF033617 392 LAIGLVVDDAIVVVENIHRHI-EEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVI 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 481 FSGFLALTMTPALCATFLApidGHQEKNGFFGWFDRNFNALTSRFDR-----LNHRLVhragrcMLVYAVL-LGVLGLAY 554
Cdd:NF033617 471 ISGIVALTLTPMMCSRLLK---ANEKPGRFARAVDRFFDGLTARYGRglkwvLKHRPL------TLVVALAtLALLPLLY 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 555 VRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPsmqEVTLVYGFSFSGS--GANAAMAFPSLRHWSE 632
Cdd:NF033617 542 VFIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDP---EVQSLTSFNGVGGnpGDNTGFGIINLKPWDE 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 633 RSDSESAANEVAAANLALGRISDATIMAVMPPPIDGLGNSGG--FSLRVQDrgnlgRDALMQAVNQLLRAANQSPKLAYA 710
Cdd:NF033617 619 RDVSAQEIIDRLRPKLAKVPGMDLFLFPLQDLPGGAGSSLPQyqVTLTPSD-----YDSLFTWAEKLKEKLRKSPQFADV 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 711 MVEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTG 790
Cdd:NF033617 694 DSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDG 773
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 791 RQVPLTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAA-LPQGI 849
Cdd:NF033617 774 KLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKElLPSGI 833
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
3-823 |
3.50e-119 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 386.31 E-value: 3.50e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 3 RFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDSSS 82
Cdd:COG3696 7 RFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 83 SNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVT-QLGlqvEQTTA-GFLMLYSLVYKDATavQDVVRLNDYAA 160
Cdd:COG3696 87 RFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTpELG---PISTGlGEIYQYTLESDPGK--YSLMELRTLQD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 161 RVVNDEIRRVPGVGRVQFFGAEA-AMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgERPGAQdqeltttLVV-- 237
Cdd:COG3696 162 WVIRPQLRSVPGVAEVNSFGGFVkQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYI-ERGGQE-------YLVrg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 238 PGLMESPQKFGQIVLRAQaNGAVVHLSDVAKLELGLENYQFDVQENG-GPAAGAAVQLAPGGNAVATVAAVRKRLQELSQ 316
Cdd:COG3696 234 IGLIRSLEDIENIVVKTR-NGTPVLLRDVAEVRIGPAPRRGAATLNGeGEVVGGIVLMLKGENALEVIEAVKAKLAELKP 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 317 SFPADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSM 396
Cdd:COG3696 313 SLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 397 FAMVLAIGILVDDAIVVVENVERLMADEGLSPRDASM-----KAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQF 471
Cdd:COG3696 393 GGLAIDFGIIVDGAVVMVENILRRLEENRAAGTPRERlevvlEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPM 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 472 SAVLAVSILFSGFLALTMTPALCATFLAPIDGHQEkNGFFGWFDRnfnaltsRFDRLNHRLVHRAGRCMLVYAVLLGVLG 551
Cdd:COG3696 473 ALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKE-NPLVRWLKR-------LYRPLLRWALRHPKLVLAVALVLLVLAL 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 552 LAYVRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPsmqEVTLVygFSFSGSGANAAMAFP------ 625
Cdd:COG3696 545 ALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFP---EVESV--VSRTGRAEDATDPMGvnmset 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 626 --SLR---HWSERSDSESAANEVAAAnlalgrisdatiMAVMPppidglGNSGGFS----LRVQD-----RGNLG----- 686
Cdd:COG3696 620 fvILKprsEWRSGRTKEELIAEMREA------------LEQIP------GVNFNFSqpiqMRVDEllsgvRADVAvkifg 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 687 --RDALMQAVNQLLRAANQSPKLAYAMVEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQR 764
Cdd:COG3696 682 ddLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFD 761
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1419931196 765 VVVQGAAGDRATPQSLDTLHVTSSTGRQVPLTVFTTQRWEQGPVQIARYNG----YASVNLTG 823
Cdd:COG3696 762 IVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGrrriVVQANVRG 824
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
5-842 |
4.03e-113 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 369.55 E-value: 4.03e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 5 FIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDSSSSN 84
Cdd:PRK09579 7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 85 GSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDATAVQdvvrLNDYAARVVN 164
Cdd:PRK09579 87 NFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYSEEMSNPQ----ITDYLSRVIQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 165 DEIRRVPGVGRVQFFGAEA-AMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQELTTTLVVPGLMES 243
Cdd:PRK09579 163 PKLATLPGMAEAEILGNQVfAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEV------KGEYVVTSINASTELKS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 244 PQKFGQIVLRAQANGAVVhLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFPADIA 323
Cdd:PRK09579 237 AEAFAAIPVKTSGDSRVL-LGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 324 YSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAI 403
Cdd:PRK09579 316 VSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAI 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 404 GILVDDAIVVVENVERLMaDEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSILFSG 483
Cdd:PRK09579 396 GLVVDDAIVVVENIHRHI-EEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISG 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 484 FLALTMTPALCATFLAPidgHQEKNGFFGWFDRNFNALTSRFDRLNHRLVHrAGRCMLVYAVLlgVLGLAYVRL---PEA 560
Cdd:PRK09579 475 IVALTLSPMMCALLLRH---EENPSGLAHRLDRLFERLKQRYQRALHGTLN-TRPVVLVFAVI--VLALIPVLLkftQSE 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 561 FVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTLVYGFSFSGSGANAAMafpsLRHWSERSDSESAA 640
Cdd:PRK09579 549 LAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGGFL----LKPWNERERTQMEL 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 641 neVAAANLALGRISDATIMAVMPPPIDGLGNSGGFSLRVQDRGNLgrDALMQAVNQLLRAANQSPKLAYAMVEGLADAPQ 720
Cdd:PRK09579 625 --LPLVQAKLEEIPGLQIFGFNLPSLPGTGEGLPFQFVINTANDY--ESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPE 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 721 LRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVTSSTGRQVPLTVFTT 800
Cdd:PRK09579 701 VVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLIT 780
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 1419931196 801 QRWEQGPVQIARYNGYASVNLTGeaAPGISSGDALAEMERLA 842
Cdd:PRK09579 781 LSDRARPRQLNQFQQLNSAIISG--FPIVSMGEAIETVQQIA 820
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
2-845 |
1.89e-104 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 346.72 E-value: 1.89e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 2 SRFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDSS 81
Cdd:PRK10503 13 SRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 82 SSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAVTQLGLQVEQTTAGFLMLYSLVYKDA---TAVQDVVRLNdy 158
Cdd:PRK10503 93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAmpmTQVEDMVETR-- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 159 aarvVNDEIRRVPGVGRVQFFGAE-AAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQELTTTLVV 237
Cdd:PRK10503 171 ----VAQKISQVSGVGLVTLSGGQrPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSL------DGPTRAVTLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 238 PGLMESPQKFGQIVLrAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQS 317
Cdd:PRK10503 241 NDQMQSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTES 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 318 FPADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMF 397
Cdd:PRK10503 320 LPKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLM 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 398 AMVLAIGILVDDAIVVVENVERLMaDEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAV 477
Cdd:PRK10503 400 ALTIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAV 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 478 SILFSGFLALTMTPALCATFLAPiDGHQEKNGFFGWFDRNFNALTSRFDRLNHRLVHRAgrcMLVYAVLLGVLGLA---Y 554
Cdd:PRK10503 479 AILISAVVSLTLTPMMCARMLSQ-ESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHP---WLTLSVALSTLLLTvllW 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 555 VRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTLVYGFSFSGSGANAAMAFPSLRHWSERS 634
Cdd:PRK10503 555 IFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERD 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 635 DS--------ESAANEVAAANLALGRISDATImavmpppiDGLGNSGGFSLRVQdrgNLGRDALMQAVNQLLRAANQSPK 706
Cdd:PRK10503 635 DRvqkviarlQTAVAKVPGVDLYLQPTQDLTI--------DTQVSRTQYQFTLQ---ATSLDALSTWVPKLMEKLQQLPQ 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 707 LAYAMVEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAGDRATPQSLDTLHVT 786
Cdd:PRK10503 704 LSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLT 783
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 1419931196 787 SSTGRQVPLTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAAL 845
Cdd:PRK10503 784 SSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTL 842
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
5-845 |
2.93e-97 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 327.07 E-value: 2.93e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 5 FIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELN---GARDMlyyDSS 81
Cdd:PRK10614 7 FIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGriaGVNEM---TSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 82 SSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAAV-TQLGLQVEQTTAGFLMLYSLVYKDATAVQdvvrLNDYAA 160
Cdd:PRK10614 84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGQ----LYDFAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 161 RVVNDEIRRVPGVGRVQFFGAE-AAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQELTTTLVVPG 239
Cdd:PRK10614 160 TQLAQTISQIDGVGDVDVGGSSlPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAV------EDGTHRWQIQTND 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 240 LMESPQKFGQIVLRAQaNGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFP 319
Cdd:PRK10614 234 ELKTAAEYQPLIIHYN-NGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIP 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 320 ADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAM 399
Cdd:PRK10614 313 AAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMAL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 400 VLAIGILVDDAIVVVENVERLMaDEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSI 479
Cdd:PRK10614 393 TIATGFVVDDAIVVLENISRHL-EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 480 LFSGFLALTMTPALCATFL--APIDGHQEKNGffgwFDRNFNALTSRFDR-----LNHrlvhragrCMLVYAVLLGVLGL 552
Cdd:PRK10614 472 GISLLVSLTLTPMMCAWLLksSKPREQKRLRG----FGRMLVALQQGYGRslkwvLNH--------TRWVGVVLLGTIAL 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 553 A---YVRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPSMQEVTlvyGFSfSGSGANAAMAFPSLRH 629
Cdd:PRK10614 540 NvwlYISIPKTFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVT---GFT-GGSRVNSGMMFITLKP 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 630 WSERSDS---------ESAANEvAAANLALgrisdatiMAVMPPPIDGLGNSGG--FSLRVQDrgnlgRDALMQAVNQLL 698
Cdd:PRK10614 616 LSERSETaqqvidrlrVKLAKE-PGANLFL--------MAVQDIRVGGRQSNASyqYTLLSDD-----LAALREWEPKIR 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 699 RAANQSPKLAYAMVEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFG----STI---VNDFvnrgrlqRVVVQGAA 771
Cdd:PRK10614 682 KALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGqrqiSTIyqpLNQY-------KVVMEVDP 754
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1419931196 772 GDRATPQSLDTLHVTSSTGRQVPLTVFTTQRWEQGPVQIARYNGYASVNLTGEAAPGISSGDALAEMERLAAAL 845
Cdd:PRK10614 755 RYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQL 828
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
13-823 |
2.43e-67 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 243.13 E-value: 2.43e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 13 WVV---AISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYYDSSSSNGSAQI 89
Cdd:TIGR00914 14 WLVllaTLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 90 TITFQPGTDPNIAQVDVQNRIRQSESRLPAAV-TQLGlqVEQTTAGFLMLYSLVYKDATAVQDVVRLNDYAARVVND--- 165
Cdd:TIGR00914 94 TVIFKDGTDLYFARQLVNERLQQARDNLPEGVsPEMG--PISTGLGEIFLYTVEAEEGARKKDGGAYTLTDLRTIQDwii 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 166 --EIRRVPGVGRVQFFGA-EAAMRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgERPGAQdqelttTLV-VPGLM 241
Cdd:TIGR00914 172 rpQLRTVPGVAEVNSIGGyVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYI-ERRGEQ------YLVrAPGQV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 242 ESPQKFGQIVLrAQANGAVVHLSDVAKLELGLENYQFDVQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQSFPAD 321
Cdd:TIGR00914 245 QSMDDIRNIVI-ATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 322 IAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAmvL 401
Cdd:TIGR00914 324 VEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGA--L 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 402 AIGILVDDAIVVVENVERLMAD----EG-LSPRDASMK----AMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFS 472
Cdd:TIGR00914 402 DFGLIVDGAVVIVENAHRRLAEaqhhHGrQLTLKERLHevfaASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMA 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 473 AVLAVSILFSGFLALTMTPALCATFlapIDGH-QEKNgffgwfDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLG 551
Cdd:TIGR00914 482 FTVVLALAGAMILSLTFVPAAVALF---IRGKvAEKE------NRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 552 LAYVRLPEAFVPQEDEGYMIVDMQLPPGASYSRTRAAGQQVNDYLAARPsmqEVTLVYGFSFSGSGA------NAAMAFP 625
Cdd:TIGR00914 553 WIASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFP---EVARVFAKTGTAEIAtdpmppNASDTYI 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 626 SLRHWSERSDSESAANEVaaanlaLGRISDATimAVMP-------PPIDGLGN--SGG----FSLRVQDRGNLGRDALMQ 692
Cdd:TIGR00914 630 ILKPESQWPEGKKTKEDL------IEEIQEAT--VRIPgnnyeftQPIQMRFNelISGvrsdVAVKVFGDDLDDLDATAE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 693 AVNQLLRaanQSPKLAYAMVEGLADAPQLRLEVDLGKAEALGVSFQSAMDVLSSAFGSTIVNDFVNRGRLQRVVVQGAAG 772
Cdd:TIGR00914 702 KISAVLK---GVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPES 778
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 773 DRATPQSLDTLHVTSSTGR-----QVPLTVFTTQRWEQGPVQIARYNG----YASVNLTG 823
Cdd:TIGR00914 779 LRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENGkrrvVVSANVRG 838
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-497 |
4.11e-29 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 125.22 E-value: 4.11e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 3 RFFIDRPNFAWVVAISISLAGLLALRTLPVEKYPEVAPPQISIMATYPGASAQLVNDAVTSAIEQELNGARDMLYY---- 78
Cdd:COG0841 520 RWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVfsvv 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 79 ---DSSSSNGSAQITITFQPGTDPNIAQVDVQNRIRQSESRLPAA---VTQLGLQVEQTTAGF-LMLYSlvykdatavQD 151
Cdd:COG0841 600 gfsGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIPGArvfVFQPPAGGLGSGAPIeVQLQG---------DD 670
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 152 VVRLNDYAARVVnDEIRRVPGVGRVQFFGAEAA--MRVWVDTQALRGYGLSIVDVNNAIRAQNLQVAAGSLgerpgaQDQ 229
Cdd:COG0841 671 LEELAAAAEKLL-AALRQIPGLVDVRSDLQLGKpeLQLDIDREKAAALGVTVADVASTLRAALGGRYVNDF------NRG 743
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 230 ELTTTLVV---PGLMESPQKFGQIVLRAqANGAVVHLSDVAKLELGLENYQFDvQENGGPAAGAAVQLAPGGNAVATVAA 306
Cdd:COG0841 744 GREYDVRVqapEEDRNSPEDLENLYVRT-PDGEMVPLSSVATIEEGTGPSSIN-RYNGQRSVTVSANLAPGVSLGEALAA 821
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 307 VRKRLQELSqsFPADIAYSVPFDSSTFVNvAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKL 386
Cdd:COG0841 822 IEELAAELK--LPPGVSIEFTGQAEEEQE-SFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLL 898
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 387 LGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMaDEGLSPRDASMKA---------MTqvggaivgitlVLTAVF--L 455
Cdd:COG0841 899 TGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLR-EEGMSLREAILEAarlrlrpilMT-----------SLATILglL 966
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 1419931196 456 PLAFMSGsVGViyrQFSAVLAVSI----LFSGFLALTMTPALCATF 497
Cdd:COG0841 967 PLALGTG-AGA---EFRQPLGIAVigglLFSTLLTLFVVPVLYVLL 1008
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
302-567 |
2.00e-22 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 103.40 E-value: 2.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 302 ATVAAVRKRLQELSQSfPADIAYS-VPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGT 380
Cdd:COG1033 181 EVVAEIRAIIAKYEDP-GVEVYLTgFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWT 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 381 FAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMAdEGLSPRDASMKAMTQVGGAIVgITLVLTAV-FLPLAF 459
Cdd:COG1033 260 LGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERR-KGLDKREALREALRKLGPPVL-LTSLTTAIgFLSLLF 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 460 MsgSVGVIyRQFSAVLAVSILFSGFLALTMTPALCATFLAPIDGHQEKNGFFGWfDRNFNALTsrfdrlnhRLVHRAGRC 539
Cdd:COG1033 338 S--DIPPI-RDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPEL-GRLLAKLA--------RFVLRRPKV 405
|
250 260 270
....*....|....*....|....*....|....
gi 1419931196 540 MLVYAVLLGVLGLAYVR------LPEAFVPQEDE 567
Cdd:COG1033 406 ILVVALVLAVVSLYGISrlkveyDFEDYLPEDSP 439
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
302-497 |
9.72e-22 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 101.09 E-value: 9.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 302 ATVAAVRKRLQELSQSFPADIAYSVPFDSSTFVNVAIKKVLH-----TLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVC 376
Cdd:COG1033 563 EEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIesqirSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLP 642
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 377 LLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMAdEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLP 456
Cdd:COG1033 643 ILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERR-KGGDLEEAIRRALRTTGKAILFTSLTLAAGFGV 721
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1419931196 457 LAFmsgSVGVIYRQFSAVLAVSILFSGFLALTMTPALCATF 497
Cdd:COG1033 722 LLF---SSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
13-493 |
7.79e-15 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 79.26 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 13 WVVAISISLAGLLAL-RTLPVEKYPEVAPPQISIMA-TYPGAS---AQLVNDAVTSAIEQELNGARDMLYYDSSSSNG-- 85
Cdd:pfam00873 530 VLLVALLLVVGSVWLfVRIPTEFLPEEDEGVFVTSAqLPPGVSldqTQRVMKQVEKILKEKPEVESVFAVTGFAFSGDnn 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 86 ---SAQITITFQPGTDPNIAQVDVQ---NRIRQSESRLPAAVTQLG----LQVEQTTAGFLMlyslvykdatAVQDVVRL 155
Cdd:pfam00873 610 gpnSGDAFISLKPWKERPGPEKSVQaliERLRKALKQIPGANVFLFqpiqLRGLGTISGFRS----------DLQVKIFG 679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 156 NDY-----AARVVNDEIRRVPGVGRVQFFGAE--AAMRVWVDTQALRGYGLSIVDVNNAiraqnLQVAAGSLgeRPGA-Q 227
Cdd:pfam00873 680 DDLdaldeARNQILAALAQLPGLSDVRSDGQEdqPQLQVNIDREKAARLGVSIQDINDT-----LSTALGGS--YVNDfP 752
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 228 DQELTTTLVV---PGLMESPQKFGQIVLRAqANGAVVHLSDVAKLELGLENYQFdVQENGGPAAGAAVQLAPG---GNAV 301
Cdd:pfam00873 753 EGGRVYDVVVqlpEDFRSSPEDIGQLYVRN-PYGKMIPLSAFAKIEWGYGPPSI-NRYNGFRSIVISGNVAAGdslGDAM 830
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 302 ATVAAVRKRLQelsqsFPADIAYSvpFDSSTFVNVAIKKVLHTLLE-AMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGT 380
Cdd:pfam00873 831 EAMAQIAKQVK-----LPPGYGYT--WTGQFEQEQLAGNSLPILIAlALLVVFLVLAALYESWSDPLSIMLTVPLALVGA 903
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 381 FAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFm 460
Cdd:pfam00873 904 LLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLAL- 982
|
490 500 510
....*....|....*....|....*....|....
gi 1419931196 461 SGSVGVIYRQFSAVLAVS-ILFSGFLALTMTPAL 493
Cdd:pfam00873 983 STGAGSELQQPLGIVVFGgLVTSTVLTLLVVPVF 1016
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
183-492 |
1.56e-11 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 68.50 E-value: 1.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 183 AAMRVWVDTQALRGYGLSIVDVNNAIraqnlqvaAGSLGERP-GAQDQELTTTLVVPGLMES----PQKFGQIVLRAQaN 257
Cdd:NF033617 702 PELNVDIDRDKAARLGISMQDIGSTL--------EVAFGQRQvNTIYTDGNQYKVVLEVDRRyrlnPEALNQIYVRSN-D 772
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 258 GAVVHLSDVAKLELGLENYQFDvQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELsqsFPADIAYSVPFDSSTFVNvA 337
Cdd:NF033617 773 GKLVPLSTLAKIEERAAPLSLN-HFNQFNSATLSFNLAPGVSLGEAIEALDQAAKEL---LPSGISGSFQGAARAFQE-E 847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 338 IKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENV 417
Cdd:NF033617 848 GSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFA 927
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1419931196 418 ERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSILFSGFLALTMTPA 492
Cdd:NF033617 928 NELQRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPV 1002
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
151-497 |
5.18e-10 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 63.51 E-value: 5.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 151 DVVRLNDYAARVVNdEIRRVPGVGRVQffgAEAA-----MRVWVDTQALRGYGLSIVDVNNAIRAQnlqvaagsLGERPG 225
Cdd:COG3696 683 DLDVLRRLAEQIEA-VLKTVPGAADVQ---VERVtglpqLDIRIDRDAAARYGLNVADVQDVVETA--------IGGKAV 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 226 AQ--DQELTTTLVV---PGLMESPQKFGQIVLRAqANGAVVHLSDVAKLELGL-------ENYQ------FDVQenggpa 287
Cdd:COG3696 751 GQvyEGERRFDIVVrlpEELRDDPEAIRNLPIPT-PSGAQVPLSQVADIEVVEgpnqisrENGRrrivvqANVR------ 823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 288 agaavqlapGGNAVATVAAVRKRLQElSQSFPADiaYSVPFdSSTFVNV--AIKKVLHTLLEAMALVFLVMFVFLQNIRY 365
Cdd:COG3696 824 ---------GRDLGSFVAEAQAKVAE-QVKLPPG--YYIEW-GGQFENLqrATARLAIVVPLALLLIFLLLYLAFGSVRD 890
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 366 TLIPAIVVPVCLLGTFAVMKLLGFSvnmMSMFAMV----LAiGILVDDAIVVVENVERLMAdEGLSPRDASMKA------ 435
Cdd:COG3696 891 ALLILLNVPFALIGGVLALWLRGMP---LSVSAGVgfiaLF-GVAVLNGVVLVSYINQLRA-EGLDLREAIIEGalerlr 965
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1419931196 436 ---MTqvggaivgitlVLTAV--FLPLAFmSGSVGV-IYRQFSAVLAVSILFSGFLALTMTPALCATF 497
Cdd:COG3696 966 pvlMT-----------ALVAAlgLLPMAL-STGPGSeVQRPLATVVIGGLITSTLLTLLVLPALYLLF 1021
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
348-493 |
1.19e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 62.16 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 348 AMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENV--ERlmadEG 425
Cdd:TIGR00921 576 GAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYfeER----KE 651
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1419931196 426 LSPRDASMKAMTQVGGAIvgITLVLTAVFLPLAFMSGSVGVIyRQFSAVLAVSILFSGFLALTMTPAL 493
Cdd:TIGR00921 652 HGPKEAITHTMERTGPGI--LFSGLTTAGGFLSLLLSHFPIM-RNFGLVQGIGVLSSLTAALVVFPAL 716
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
285-535 |
2.12e-09 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 60.00 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 285 GPAAGAAVQLA--PGGN-AVATVAAVRKRLQELSQSFPADIAYSVPFDSSTFVNVAIKKVLHTL-LEAMALVFLVMFVFL 360
Cdd:pfam03176 84 GKAAYVVVTLEgdPGTTeADESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIeAVTLVVIFIILLIVY 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 361 QNIRYTLIPAIVVPVCLLGTFAVM----KLLGFSVNMMS-MFAMVLAIGILVDDAIVVVENVeRLMADEGLSPRDASMKA 435
Cdd:pfam03176 164 RSVVAALLPLLTVGLSLGAAQGLVailaHILGIGLSTFAlNLLVVLLIAVGTDYALFLVSRY-REELRAGEDREEAVIRA 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 436 MTQVGGAIVGITLVLTAVFLPLAFmsgSVGVIYRQFSAVLAVSILFSGFLALTMTPALCATFlapidghqeknGFFGWFD 515
Cdd:pfam03176 243 VRGTGKVVTAAGLTVAIAMLALSF---ARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALL-----------GRWGLWP 308
|
250 260
....*....|....*....|
gi 1419931196 516 RNFNALTSRFDRLNHRLVHR 535
Cdd:pfam03176 309 PKRDRTARWWRRIGRLVVRR 328
|
|
| SecD |
COG0342 |
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ... |
337-493 |
2.45e-08 |
|
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440111 [Multi-domain] Cd Length: 434 Bit Score: 57.05 E-value: 2.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 337 AIKKVLHTLLEAMALVFLVMFvflqnIRYTLiPAIVVPVCLLG----TFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIV 412
Cdd:COG0342 269 SIEKGLIAGLIGLLLVALFML-----LYYRL-PGLVANIALALnvvlLLGVLSLLGATLTLPGIAGIILTIGMAVDANVL 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 413 VVENV-ERLmaDEGLSPRDASMKAMTQVGGAIVG--ITLVLTAVFLpLAFMSGSVgviyRQFSAVLAVSILFSGFLALTM 489
Cdd:COG0342 343 IFERIrEEL--RAGRSLRAAIEAGFKRAFSTILDanVTTLIAAVVL-FVLGTGPV----KGFAVTLILGILISMFTAVPV 415
|
....
gi 1419931196 490 TPAL 493
Cdd:COG0342 416 TRPL 419
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
344-493 |
2.79e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 57.54 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 344 TLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMaD 423
Cdd:TIGR00921 198 TMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEER-D 276
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 424 EGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFmsgSVGVIYRQFSAVLAVSILFSGFLALTMTPAL 493
Cdd:TIGR00921 277 IGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALAL---SEFPMVSEFGLGLVAGLITAYLLTLLVLPAL 343
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
287-557 |
3.43e-08 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 57.08 E-value: 3.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 287 AAGAAVQLA--PGGNAVATVAAVRKRLQELSqsfPADIAYSV---PFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQ 361
Cdd:COG2409 115 AALVTVTLDgdAGDEAAEAVDALRDAVAAAP---APGLTVYVtgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFR 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 362 NIRYTLIPAIVVPVCLLGTFAVMKLLG-------FSVNMMSMfaMVLAIGIlvDDAIVVV----ENVERlmadeGLSPRD 430
Cdd:COG2409 192 SLVAALLPLLTAGLAVGVALGLLALLAaftdvssFAPNLLTM--LGLGVGI--DYALFLVsryrEELRA-----GEDREE 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 431 ASMKAMTQVGGAIV--GITLV---LTAVFLPLAFmsgsvgviYRQFSAVLAVSILFSGFLALTMTPALCATFlapidGHQ 505
Cdd:COG2409 263 AVARAVATAGRAVLfsGLTVAialLGLLLAGLPF--------LRSMGPAAAIGVAVAVLAALTLLPALLALL-----GRR 329
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1419931196 506 EKNGFFGWFDRNFNALTSRFDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRL 557
Cdd:COG2409 330 VFWPRRPRRRRAAAPESGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGL 381
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
325-487 |
4.87e-08 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 53.80 E-value: 4.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 325 SVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVFLQnIRYTL--IPAIVVPVCLlgTFAVMKLLGFSVNMMSMFAMVLA 402
Cdd:TIGR00916 33 VVGTVGPTLGGELIKAGIIALLIGLVLVLLYMLLRYE-WRGAIaaIAALVHDVIL--ILGVLSLFGATLTLPGIAGLLTI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 403 IGILVDDAIVVVENV-ERLMADEGLSPRDASMKAMTQVGGAIV--GITLVLTAVFLpLAFMSGSVgviyRQFSAVLAVSI 479
Cdd:TIGR00916 110 IGYSVDDTVVIFDRIrEELRKYKGRTFREAINLGINQTLSRIIdtNVTTLLAVLAL-YVFGGGAI----KGFALTLGIGV 184
|
....*...
gi 1419931196 480 LFSGFLAL 487
Cdd:TIGR00916 185 IAGTYSSI 192
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
280-580 |
2.84e-07 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 280 VQENGGPAAGAAVQLAPGGNAVATVAAVRKRLQELSQ-SFPADIAYSVPFDSSTFVNVAI---KKVLHTLLEAMALVFLV 355
Cdd:TIGR00833 110 LRSDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQtNAPDGLTVHVTGPLATIADILEsgdKDMNRITATTGIIVLII 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 356 MFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLG----FSVNMMS-MFAMVLAIGILVDDAIVVVENV-ERLMADEglSPR 429
Cdd:TIGR00833 190 LLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGipglIGVNAQTtVLLTALVIGAGTDYAVFLTGRYhEERRKGE--SLE 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 430 DASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVgviYRQFSAVLAVSILFSGFLALTMTPALCATFlapidghqeknG 509
Cdd:TIGR00833 268 EAAAEALRGTGKAILGSALTVAVAFLALSLARLPS---FKTLGVSCAVGVLVALLNAVTLTPALLTLE-----------G 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 510 FFGWFDRNFNALTSR-FDRLNHRLVHRAGRCMLVYAVLLGVLGLAYVRLP-----EAFVPQ---EDEGYMIVDMQLPPGA 580
Cdd:TIGR00833 334 REGLMKPGRKSKIRFiWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRtgyddEKMIPTdleSVQGYEAADRHFPGNS 413
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
160-498 |
3.75e-07 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 54.00 E-value: 3.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 160 ARVVNDEIRRVPGVG--RVQFFGAEAAMRVWVDTQALRGYGLSIVDVNNAIraqnlqvaAGSLGERPGAQ----DQELTT 233
Cdd:TIGR00914 700 AEKISAVLKGVPGAAdvKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTV--------ATAVGGRMSGEtfegDRRFDI 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 234 TLVVPG-LMESPQKFGQI-VLRAQANGAVVH---LSDVAKLELGLENYQFDvQENGGPAAGAAVQlAPGGNAVATVAAVR 308
Cdd:TIGR00914 772 VIRLPEsLRESPQALRQLpIPLPLSEDARKQfipLSDVADLRVSPGPNQIS-RENGKRRVVVSAN-VRGRDLGSFVDDAK 849
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 309 KRLQELSQSFPAdiaYSVPFdSSTFVNV--AIKKVLHTLLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKL 386
Cdd:TIGR00914 850 KAIAEQVKLPPG---YWITW-GGQFEQLqsATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWL 925
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 387 LGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMaDEGLSPRDASMK-AMTQVGGAIVgITLVLTAVFLPLAFMSGSVG 465
Cdd:TIGR00914 926 RGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLL-EEGPSLDEAVYEgALTRVRPVLM-TALVASLGFVPMAIATGTGA 1003
|
330 340 350
....*....|....*....|....*....|...
gi 1419931196 466 VIYRQFSAVLAVSILFSGFLALTMTPALCATFL 498
Cdd:TIGR00914 1004 EVQRPLATVVIGGIITATLLTLFVLPALYRLVH 1036
|
|
| secD |
TIGR01129 |
protein-export membrane protein SecD; Members of this family are highly variable in length ... |
337-493 |
6.01e-07 |
|
protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273456 [Multi-domain] Cd Length: 397 Bit Score: 52.67 E-value: 6.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 337 AIKKVLHTLLEAMALVFLVMFVFLQNIryTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVEN 416
Cdd:TIGR01129 246 SIEAGIKAGLIGLVLVLVFMILYYRLF--GLIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDANVLIYER 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1419931196 417 VERLMAdEGLSPRDASMKAMTQVGGAIV--GITLVLTAVFLpLAFMSGSVgviyRQFSAVLAVSILFSGFLALTMTPAL 493
Cdd:TIGR01129 324 IKEELR-LGKSVRQAIEAGFERAFSTIFdaNITTLIAALIL-YVFGTGPV----KGFAVTLAIGIIASLFTALVFTRLL 396
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
222-490 |
5.96e-06 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 50.23 E-value: 5.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 222 ERPGAQDQE-----LTTTLVVPGLMESPQKFGQIVLRAQANGAVVHLSDVAKLELGLE-----NYQFDVQENGGPA---- 287
Cdd:PRK13024 93 ELPGVQDPErarelLGSTAKLTFRDVTDPPPPGVGGPVVGPDEGKDTAVLNPVLLSGDdltdaGAKFDQDQTNRPSvslk 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 288 ---AGA---------AVQLAPGGNAVA--------TVAAVRkrlQELSQ-------SFPA----DIA---------YSVP 327
Cdd:PRK13024 173 lksEGAkkwakvtekNSKKGPPNNRIAivldpkviSAPTVN---QPINGgsvqisgNFTVeeakDLAnllnagalpAPLK 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 328 FDSSTFVN-----VAIKKVLHTLLEAMALVFLVMFVF------LQNIrytlipAIVVPVCLlgTFAVMKLLGFSVNMMSM 396
Cdd:PRK13024 250 IIESRSVGptlgqDAIDAGIIAGIIGFALIFLFMLVYyglpglIANI------ALLLYIFL--TLGALSSLGAVLTLPGI 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 397 FAMVLAIGILVDDAIVVVENV-ERLMAdeGLSPRDASMKAMTQVGGAIV--GITLVLTAVFLpLAFMSGSVgviyRQFSA 473
Cdd:PRK13024 322 AGLVLGIGMAVDANVLIFERIkEELRK--GKSLKKAFKKGFKNAFSTILdsNITTLIAAAIL-FFFGTGPV----KGFAT 394
|
330
....*....|....*..
gi 1419931196 474 VLAVSILFSGFLALTMT 490
Cdd:PRK13024 395 TLIIGILASLFTAVFLT 411
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
256-501 |
7.67e-06 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 49.85 E-value: 7.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 256 ANGAVVHLSDVAKLELGLENYQFdVQENGGPAAGAAVQLAPGGNAVATVAAvrkrLQELSQSFPADIAYSVPFDS-STFV 334
Cdd:PRK09577 788 AQGEMVPLAAFATLHWTLGPPQL-TRYNGYPSFTINGSAAPGHSSGEAMAA----IERIAATLPAGIGYAWSGQSfEERL 862
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 335 NVAIKKVLHTLleAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVV 414
Cdd:PRK09577 863 SGAQAPMLFAL--SVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIV 940
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 415 ENVERLMAdEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGsvgviyrqfSAVLAVSILFSGFLALTMTPALC 494
Cdd:PRK09577 941 EVAKDLVA-QRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASG---------AASGAQIAIGTGVLGGVITATVL 1010
|
....*..
gi 1419931196 495 ATFLAPI 501
Cdd:PRK09577 1011 AVFLVPL 1017
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
345-492 |
1.52e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 48.70 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 345 LLEAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVvenverlmaDE 424
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFF---------TE 715
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1419931196 425 GLSPRDASMKAMTqvggaivGITL-VLTAV--FLPLAFmsGSVGVIyRQFSAVLAVSILFSGFLALTMTPA 492
Cdd:COG4258 716 GLLDKGELARTLL-------SILLaALTTLlgFGLLAF--SSTPAL-RSFGLTVLLGILLALLLAPLLAPR 776
|
|
| secD |
PRK05812 |
preprotein translocase subunit SecD; Reviewed |
337-493 |
2.33e-05 |
|
preprotein translocase subunit SecD; Reviewed
Pssm-ID: 235615 [Multi-domain] Cd Length: 462 Bit Score: 47.91 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 337 AIKKVLHTLLEAMALVFLVMFVFlqnirYT---LIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVV 413
Cdd:PRK05812 295 SIRAGLIAGLIGLALVLLFMILY-----YRlfgLIANIALVANLVLILAVLSLLGATLTLPGIAGIVLTIGMAVDANVLI 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 414 VENV-ERLMadEGLSPRDA----SMKAMTqvggAIV--GITLVLTAVFLpLAFMSGSVgviyRQFSAVLAVSILFSGFLA 486
Cdd:PRK05812 370 FERIrEELR--EGRSLRSAieagFKRAFS----TILdsNITTLIAAIIL-YALGTGPV----KGFAVTLGIGILTSMFTA 438
|
....*..
gi 1419931196 487 LTMTPAL 493
Cdd:PRK05812 439 ITVTRAL 445
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
348-506 |
3.46e-05 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 47.52 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 348 AMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLMADEGLS 427
Cdd:PRK09579 853 ALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLS 932
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1419931196 428 PRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGSVGVIYRQFSAVLAVSILFSGFLALTMTPALcATFLAPIDGHQE 506
Cdd:PRK09579 933 RREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCI-YTLLAKPDAAPG 1010
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
338-497 |
1.44e-04 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 45.67 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 338 IKKVLHTLLEAMALVFLVMFVFLQ-NIRYTLIPAIVVPVCLLGTFAVMKLLGFSVNMMSMFAMVLAIGIlvddAIVVVEN 416
Cdd:TIGR00917 1048 WKTAIINLSIALGAIFIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGI----AIEFCTH 1123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 417 VERLMADEGLSPRDASMK-AMTQVGGAIV-GITLVLTAVFLPLAFMSGSVGVIYrQFSAVLAvsILFSGFL-ALTMTPAL 493
Cdd:TIGR00917 1124 INAQFSTGKHFSRNHRAKeALGGMGSSVFsGITLTKLVGVVVLGFSRSEIFVVY-YFRMYLA--LVLLGFLhGLVFLPVL 1200
|
....
gi 1419931196 494 CATF 497
Cdd:TIGR00917 1201 LSVL 1204
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
293-493 |
1.94e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 45.37 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 293 QLAPGGNAVATVAAVRKRLQeLSQSFPAD--IAYSVPFDSSTFVNVAIKKVLHTLLeAMALVFLVMFVFLQNIRytLIPA 370
Cdd:TIGR03480 223 SLEPAEKAINAIRAAAKDLR-LDEDHGVTvrLTGEVALSDEELATVSEGATVAGLL-SFVLVLVLLWLALRSPR--LVFA 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 371 IVVP--VCLLGTFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVERLmADEGLSPRDASMKAMTQVGGAIVGITL 448
Cdd:TIGR03480 299 VLVTliVGLILTAAFATLAVGHLNLISVAFAVLFIGLGVDFAIQFSLRYREE-RFRGGNHREALSVAARRMGAALLLAAL 377
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1419931196 449 VlTAV----FLPLAFmsgsVGVIyrQFSAVLAVSILFSGFLALTMTPAL 493
Cdd:TIGR03480 378 A-TAAgffaFLPTDY----KGVS--ELGIIAGTGMFIALFVTLTVLPAL 419
|
|
| PRK14726 |
PRK14726 |
protein translocase subunit SecDF; |
348-498 |
1.21e-03 |
|
protein translocase subunit SecDF;
Pssm-ID: 237805 [Multi-domain] Cd Length: 855 Bit Score: 42.78 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 348 AMALVFLVMFVFLQNIRYTLIPAIVVPVCLLgtFAVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVVENVeRLMADEGLS 427
Cdd:PRK14726 381 AAILVAALMIGFYGFLGVIAVIALIVNVVLI--IAVLSLLGATLTLPGIAGIVLTIGMAVDSNVLIYERI-REEEKTGHS 457
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1419931196 428 PRDASMKAMTQVGGAIV--GITLVLTAVFLplaFMSGSVGViyRQFSAVLAVSILFSGFLALTMTPALCATFL 498
Cdd:PRK14726 458 LIQALDRGFSRALATIVdaNVTILIAAVIL---FFLGSGAV--RGFAVTLAVGILTTVFTAFTLTRSLVAVWL 525
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
312-495 |
2.11e-03 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 41.96 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 312 QELSQSF---PADIAYSVPFDSSTFVNVAIKKVLHTLLEAMALVFLVMFVF------------LQNIRYTLIPAI---VV 373
Cdd:pfam02460 179 DELSQLLhnkYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFsiivsvtlssytIDWVRSKPILAAlglLS 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 374 PVCLLGT-FAVMKLLGF---SVNMMSMFaMVLAIGilVDDAIVVVENVERLMADegLSPRDASMKAMTQVGGAIVgITlV 449
Cdd:pfam02460 259 PVMAIVSsFGLLFWMGFpfnSIVCVTPF-LVLAIG--VDDMFLMVAAWQRTTAT--LSVKKRMGEALSEAGVSIT-IT-S 331
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1419931196 450 LTAVflpLAFMSGSVGVI--YRQFSAVLAVSILFSGFLALTMTPALCA 495
Cdd:pfam02460 332 LTDV---LSFGIGTYTPTpaIQLFCAYTAVAIFFDFIYQITFFAAIMA 376
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
341-460 |
3.29e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.14 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 341 VLHTLLEAMALVF----LVMFVFLQNIRYTLIpaIVVPVCLLGTF--AVMKLLGFSVNMMSMFAMVLAIGILVDDAIVVV 414
Cdd:TIGR03480 710 VVGAFLQAFIYALvaitVLLLLTLRRVRDVLL--VLAPLLLAGLLtvAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMV 787
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1419931196 415 ENVERLMADEGL---------------------------SPRDASMKAMTQVGgaiVGITLVLTAVFLPlAFM 460
Cdd:TIGR03480 788 HRWRNGVDSGNLlqsstaravffsalttatafgslavssHPGTASMGILLSLG---LGLTLLCTLIFLP-ALL 856
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
348-493 |
4.74e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 40.52 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 348 AMALVFLVMFVFLQnirytlipAIVVPVCLLGTFAV----------------MKLLGFSVNMMSMFAMVLAIGILV---- 407
Cdd:COG2409 526 VLGLIFLLLLLLFR--------SVVAPLKAVLTNLLslgaalgvlvlvfqhgWLLLGFTPGPLDSFVPLLLFVILFglgm 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 408 DDAIVVVENVeRLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFlpLAFMSGSVGVIyRQFSAVLAVSILFSGFL-A 486
Cdd:COG2409 598 DYEVFLVSRI-REEYDRGGGTREAVIRGLARTGRVITSAALIMAAVF--AAFATSPLVFL-KQIGFGLAVGVLLDAFVvR 673
|
....*..
gi 1419931196 487 LTMTPAL 493
Cdd:COG2409 674 MLLVPAL 680
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
244-463 |
7.17e-03 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 40.27 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 244 PQKFGQIVLRAqANGAVVHLS--DVAKLELG---LENYqfdvqeNGGPAAGAAVQLAPG---GNAVATvaavrkrLQELS 315
Cdd:PRK15127 783 PDDIGDWYVRA-ADGQMVPFSafSSSRWEYGsprLERY------NGLPSMEILGQAAPGkstGEAMEL-------MEELA 848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1419931196 316 QSFPADIAYS---VPFDSSTFVNVAikKVLHTLleAMALVFLVMFVFLQNIRYTLIPAIVVPVCLLGTFAVMKLLGFSVN 392
Cdd:PRK15127 849 SKLPTGVGYDwtgMSYQERLSGNQA--PALYAI--SLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTND 924
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1419931196 393 MMSMFAMVLAIGILVDDAIVVVENVERLMADEGLSPRDASMKAMTQVGGAIVGITLVLTAVFLPLAFMSGS 463
Cdd:PRK15127 925 VYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGA 995
|
|
| |
