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Conserved domains on  [gi|2089723642|gb|QZX51335|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, partial [Gonium multicoccum]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-303 6.99e-75

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 232.32  E-value: 6.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  43 TVKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyATADTLECSDPSIPSDDSNLVIKALNLYRRKTF 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 123 QTMYFHVKLNKRVPHgaglgggSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVQP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSAA-DPRGLLADIAAARGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250       260
                  ....*....|....*....|..
gi 2089723642 282 GlFRSVFMTGSGSTIVGFGSDQ 303
Cdd:COG1947   238 G-ALAARMSGSGSTVFGLFEDE 258
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-303 6.99e-75

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 232.32  E-value: 6.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  43 TVKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyATADTLECSDPSIPSDDSNLVIKALNLYRRKTF 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 123 QTMYFHVKLNKRVPHgaglgggSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVQP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSAA-DPRGLLADIAAARGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250       260
                  ....*....|....*....|..
gi 2089723642 282 GlFRSVFMTGSGSTIVGFGSDQ 303
Cdd:COG1947   238 G-ALAARMSGSGSTVFGLFEDE 258
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 48-298 1.58e-36

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 133.41  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  48 SPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTpyATADT-LECSDPSIPsDDSNLVIKALNLYRRKTFQTMY 126
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVR--SDDDIrLLKGDFDVP-LEENLAYRAAQLLKNFANSKIK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 127 ----FHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVqp 202
Cdd:TIGR00154  84 sldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPF-- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPLDTPMLLVKPPVGLSTPRIFKSLDLARRSAADPRGLLADIAAA-RGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 281
Cdd:TIGR00154 162 EDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLEcLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEY 241

                         250
                  ....*....|....*..
gi 2089723642 282 GLfRSVFMTGSGSTIVG 298
Cdd:TIGR00154 242 GL-APERMSGSGPCVFA 257
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 47-337 1.40e-33

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 125.35  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  47 FSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTtpyATADTLECSDPS---IPSDDSNLVIKALNLYRRKTFQ 123
Cdd:PRK14608   10 FAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEP---AEALSLTVSGPFaagLGDGDDNLVLRAARALRARVGP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 124 -TMYFHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVqP 202
Cdd:PRK14608   87 gLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELTPL-P 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPlDTPMLLVKPPVGLSTPRIFKSLDLARRSA--------ADPRGLLADIAAARgvdqaaavNDLEQPAFDNLPELAAL 274
Cdd:PRK14608  166 GLP-SLPAVLVNPGVPVATPDVFRALGLRDGPPlpgapdplASADALLAALAATR--------NDLEPPALALAPVIGEV 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2089723642 275 KQRLIDSGLFRSVFMTGSGSTIVG-FGSDQVPSFLtseeqykdlfispARLITRQPGGWYSHSG 337
Cdd:PRK14608  237 LAALRAQPGALLARMSGSGATCFAlFADEAAAEAA-------------AAAIAAAHPGWWVKAT 287
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-303 6.99e-75

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 232.32  E-value: 6.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  43 TVKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyATADTLECSDPSIPSDDSNLVIKALNLYRRKTF 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 123 QTMYFHVKLNKRVPHgaglgggSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVQP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSAA-DPRGLLADIAAARGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250       260
                  ....*....|....*....|..
gi 2089723642 282 GlFRSVFMTGSGSTIVGFGSDQ 303
Cdd:COG1947   238 G-ALAARMSGSGSTVFGLFEDE 258
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 48-298 1.58e-36

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 133.41  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  48 SPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTpyATADT-LECSDPSIPsDDSNLVIKALNLYRRKTFQTMY 126
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVR--SDDDIrLLKGDFDVP-LEENLAYRAAQLLKNFANSKIK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 127 ----FHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVqp 202
Cdd:TIGR00154  84 sldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPF-- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPLDTPMLLVKPPVGLSTPRIFKSLDLARRSAADPRGLLADIAAA-RGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 281
Cdd:TIGR00154 162 EDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLEcLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEY 241

                         250
                  ....*....|....*..
gi 2089723642 282 GLfRSVFMTGSGSTIVG 298
Cdd:TIGR00154 242 GL-APERMSGSGPCVFA 257
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 47-337 1.40e-33

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 125.35  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  47 FSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTtpyATADTLECSDPS---IPSDDSNLVIKALNLYRRKTFQ 123
Cdd:PRK14608   10 FAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEP---AEALSLTVSGPFaagLGDGDDNLVLRAARALRARVGP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 124 -TMYFHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVqP 202
Cdd:PRK14608   87 gLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELTPL-P 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVPlDTPMLLVKPPVGLSTPRIFKSLDLARRSA--------ADPRGLLADIAAARgvdqaaavNDLEQPAFDNLPELAAL 274
Cdd:PRK14608  166 GLP-SLPAVLVNPGVPVATPDVFRALGLRDGPPlpgapdplASADALLAALAATR--------NDLEPPALALAPVIGEV 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2089723642 275 KQRLIDSGLFRSVFMTGSGSTIVG-FGSDQVPSFLtseeqykdlfispARLITRQPGGWYSHSG 337
Cdd:PRK14608  237 LAALRAQPGALLARMSGSGATCFAlFADEAAAEAA-------------AAAIAAAHPGWWVKAT 287
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
45-304 6.26e-31

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 117.93  E-value: 6.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  45 KLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYATADTlecSDPSIPSDDsNLVIKALNLYRRKTFQT 124
Cdd:PRK14611    3 VLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHTLEVKT---SSPQIKEEE-NIVYKALRLFERYTGID 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 125 MYFHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVqpPV 204
Cdd:PRK14611   79 INYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFL--EK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 205 PLDTPMLLVKPPVGLSTPRIFKSLDLARRSAADPRGLLADIAAARGVDQAAAV--NDLEQPAFDNLPELAALkQRLIDSG 282
Cdd:PRK14611  157 PISREITLVYPNIKSSTGRVYSKVTKQILTNKEDLNIIISLLREGEEKKIEEVieNTLGEIALELYPEIKEV-YRFLEYL 235

                         250       260
                  ....*....|....*....|....
gi 2089723642 283 LFRSvFMTGSGSTIVGFG--SDQV 304
Cdd:PRK14611  236 GYKP-FVSGSGSSVYVFGkpSEEV 258
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 49-297 5.25e-29

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 113.45  E-value: 5.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  49 PSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYAtadTLECSDPS---IPSDDSNLVIKALNLYRRKTFQTM 125
Cdd:PRK03188    6 PAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVL---SVEVSGEGadqVPTDESNLAWRAAELLAEHVGRAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 126 YFHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSNGAAYCTGRGEVVEDVQPPVP 205
Cdd:PRK03188   83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLARGT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 206 LDtpMLLVKPPVGLSTPRIFKSLDLARRSAADPR-----GLLAdiAAARG-VDQAAAV--NDLEQPAFDNLPELAALKQR 277
Cdd:PRK03188  163 FH--WVLAFADGGLSTPAVFRELDRLREAGDPPRlgepdPLLA--ALRAGdPAQLAPLlgNDLQAAALSLRPSLRRTLRA 238

                         250       260
                  ....*....|....*....|
gi 2089723642 278 LIDSGLFRSVfMTGSGSTIV 297
Cdd:PRK03188  239 GEEAGALAGI-VSGSGPTCA 257
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
46-298 4.15e-17

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 80.33  E-value: 4.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  46 LFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTttpyatadtlecsdpsiPSDDSNLVIKALN---LYRRKTF 122
Cdd:PRK14613    1 MISPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIE-----------------PAPNGVFELFSTNeiiLEKRKLY 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 123 Q-------------TMYFH-------------VKLNKRVPHGAGLGGGSGNAATTLfaaNRLMG--NPASNEDLLAWSGE 174
Cdd:PRK14613   64 DqvsergdikqnilYKTFIkarslfpelpgvkIHLTKRISPAGGLGGGSTNAASLL---NFLFSwrNFFTSDEMQVFAKE 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 175 IGSDISVFFSNGAAYCTGRGEVVEDVQPPVPLDtpmLLVKPPVGLSTPRIFKSLDLA-RRSAADPRG--LLADIAAARGV 251
Cdd:PRK14613  141 IGSDVPFFLGEGHAFVTGKGEIMEEIEVHKGQG---ILALTPQVMNTGEMYALLKKPlQESASQKNGntLSEDLISSLKV 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2089723642 252 D-----QAAAVNDLEQPAFDNLPELAALKQRLIDSGlfrSVF--MTGSGSTIVG 298
Cdd:PRK14613  218 GdwvslQGRLENDFEPVAFQLHPELGVLKDKFLEFG---SSYcsLTGSGSSMYG 268
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 51-295 3.34e-12

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 65.75  E-value: 3.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  51 KINLFLRVVRRReDGYHDLASLF-HVIDLGDEMEFTTTPYAtADTLECsDPSIPSDDsNLVIKALNLYRRKTFQT----- 124
Cdd:PRK04181    8 KVNIFLKILGKR-GNYHELISRFvLVKDLFDEIEFVPKSAE-SFELIG-NFDCPLEE-NIIYKAYQELKNKGFSNelief 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 125 MYFH-VKLNKRVPHGAGLGGGSGNAATTLFAANRLMGNPASNEDLLAWSGEIGSDISVFFSN-GAAYCTGRGEVVEDVQP 202
Cdd:PRK04181   84 FKKKaIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEEFEE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 203 PVP-LDtpmlLVKPPVGLSTPRIFK----------SLDLARR-SAADPRGLLADIaaargvdQAAAVNDLEQPAFDNLPE 270
Cdd:PRK04181  164 EILnLE----IFTPNIFCSTKAVYKayreefydfiSFNQAKElLKLSSLELLKNF-------KNTELNDLLAPALKLYPA 232

                         250       260
                  ....*....|....*....|....*
gi 2089723642 271 LAalkqrlidSGLFRSVFMTGSGST 295
Cdd:PRK04181  233 LK--------DYLGEDWFFSGSGSS 249
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
48-299 7.93e-10

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 58.71  E-value: 7.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  48 SPSKINLFLRVVRRRED-GYHDLASLFHVI-DLGDEMEFTTTPYATADTL---ECSDPSIPSDDsnLVIKALNLYRRKTF 122
Cdd:PRK05905    5 SYAKINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEIEKIEKNIDDIHyfdETNEILVYSRL--ILVKTLEWLRDKYN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 123 QTMYFHVKLNKRVPHGAGLGGGSGNAATTLFAANRLMG-NPASNEDLLAwsgEIGSDISVFFSN-GAAYCTGRGEVVEDV 200
Cdd:PRK05905   83 IKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEFEGiNEINYKDVVN---KLGSDIPFFLSGyKTAYISDYGSQVEDL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 201 QPPVPLDTPMLLVKppVGLSTPRIFKSLDLARRSAADprGLLADIAAARGVDQAAAVNDLEQPAFDNLPELAALKQRLID 280
Cdd:PRK05905  160 IGQFKLTYKVIFMN--VNVSTKKVFEKFDDNQHVIKN--NFKTIIKNLKENIVVNIHNDLQEPCFELYPNLLYKYNELLN 235

                         250
                  ....*....|....*....
gi 2089723642 281 SGLFrsVFMTGSGSTIVGF 299
Cdd:PRK05905  236 DGFY--TILSGAGSSFIVI 252
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 76-302 8.93e-08

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 52.79  E-value: 8.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642  76 IDLGDEMEFTTTPyatADTLE-----CSDPSIPSDDSNLVIKALNLYRRKTFQTMY-FHVKLNKRVPHGaglgggsgnaa 149
Cdd:COG0083    25 LSLYDEVEVERSD---EPGLEieiegEGADELPTDEDNLVYQAALALLEKLGKEPPgLRIEIEKGIPLGrglgssaaaiv 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 150 ttLFAANRLMGNPASNEDLL--AWSGEIGSDisvffsN-GAAY------CTGRGEVVEDVQPPVPLDTPMLLVKPPVGLS 220
Cdd:COG0083   102 agLVAANALLGLPLSKEELLelATEGEGHPD------NvAPALlgglvlSRSDGEPVRVVRLPVPPDLKAVVVIPDFELS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 221 T-------PrifKSLDLA------RRSAADPRGLLA-DIAAARgvdqaAAVND-LEQPA-FDNLPELAALKQRLIDSGLF 284
Cdd:COG0083   176 TkearavlP---KQVPLKdavfnsSRAALLVAALATgDYELLG-----RAMEDrLHEPYrAKLIPGFDEVKEAALEAGAL 247

                         250
                  ....*....|....*...
gi 2089723642 285 rSVFMTGSGSTIVGFGSD 302
Cdd:COG0083   248 -GAGISGAGPTVLALADD 264
PRK01212 PRK01212
homoserine kinase; Provisional
 102-175 3.21e-03

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 38.98  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723642 102 IPSD-DSNLVIKALNLYRRKTFQTMYFHVKLNKRVPHgaglgggsgnaaT------------TLFAANRLMGNPASNEDL 168
Cdd:PRK01212   56 LPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPL------------GrglgssaasivaGLVAANELAGLPLSKEEL 123


                  ....*..
gi 2089723642 169 LAWSGEI 175
Cdd:PRK01212  124 LQLATEG 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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