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Conserved domains on  [gi|2089723634|gb|QZX51331|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, partial [Volvox obversus]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 46-303 7.02e-68

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 214.22  E-value: 7.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  46 SIKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLPyATSDTLECSDPTIPSDDSNLVIKALNLYRRKTM 125
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 126 QTMYFDVKLNKRVPHgaglgggSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGEVVEEVPP 205
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 206 PVPLetPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 284
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723634 285 GnFRSVFMTGSGSTivCFG 303
Cdd:COG1947   238 G-ALAARMSGSGST--VFG 253
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 46-303 7.02e-68

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 214.22  E-value: 7.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  46 SIKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLPyATSDTLECSDPTIPSDDSNLVIKALNLYRRKTM 125
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 126 QTMYFDVKLNKRVPHgaglgggSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGEVVEEVPP 205
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 206 PVPLetPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 284
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723634 285 GnFRSVFMTGSGSTivCFG 303
Cdd:COG1947   238 G-ALAARMSGSGST--VFG 253
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 46-299 1.83e-32

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 122.62  E-value: 1.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  46 SIKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLPYATSdTLECSDPTIPsDDSNLVIKALNLYRRKTM 125
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDI-RLLKGDFDVP-LEENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 126 QTMY----FDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGevve 201
Cdd:TIGR00154  80 SKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRG---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 202 evPPPVPLETP----MLLVKPPVGLSTPRIFKSLDLARrsTADPRVLLAEIAAAKGVDQAAA---VNDLEQPAFDNLPEL 274
Cdd:TIGR00154 156 --EIITPFEDPpekwVVIAKPHVSVSTPVVYQAYKLPR--NTPKRAKEWLKKISLECLQLLDsngLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|....*
gi 2089723634 275 AALKQRLIDSGnFRSVFMTGSGSTI 299
Cdd:TIGR00154 232 AQALNWLLEYG-LAPERMSGSGPCV 255
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 50-339 8.21e-31

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 118.03  E-value: 8.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  50 FSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMefsTLPYATSDTLECSDPT---IPSDDSNLVIKALNLYRRKTMQ 126
Cdd:PRK14608   10 FAPAKINLALHVTGRRADGYHLLESLVAFADVGDRL---TLEPAEALSLTVSGPFaagLGDGDDNLVLRAARALRARVGP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 127 -TMYFDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAayCTGRGEVVEEVPP 205
Cdd:PRK14608   87 gLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRP--LIMRGIGEELTPL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 206 PVPLETPMLLVKPPVGLSTPRIFKSLDLARRSTADPRVLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLIDSG 285
Cdd:PRK14608  165 PGLPSLPAVLVNPGVPVATPDVFRALGLRDGPPLPGAPDPLASADALLAALAATRNDLEPPALALAPVIGEVLAALRAQP 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 286 NFRSVFMTGSGSTivCFGsesmpaflreeqfkdLFISP------ARLITRKPAGWYTHSG 339
Cdd:PRK14608  245 GALLARMSGSGAT--CFA---------------LFADEaaaeaaAAAIAAAHPGWWVKAT 287
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 46-303 7.02e-68

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 214.22  E-value: 7.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  46 SIKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLPyATSDTLECSDPTIPSDDSNLVIKALNLYRRKTM 125
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 126 QTMYFDVKLNKRVPHgaglgggSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGEVVEEVPP 205
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 206 PVPLetPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLIDS 284
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723634 285 GnFRSVFMTGSGSTivCFG 303
Cdd:COG1947   238 G-ALAARMSGSGST--VFG 253
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 46-299 1.83e-32

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 122.62  E-value: 1.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  46 SIKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLPYATSdTLECSDPTIPsDDSNLVIKALNLYRRKTM 125
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDI-RLLKGDFDVP-LEENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 126 QTMY----FDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGevve 201
Cdd:TIGR00154  80 SKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRG---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 202 evPPPVPLETP----MLLVKPPVGLSTPRIFKSLDLARrsTADPRVLLAEIAAAKGVDQAAA---VNDLEQPAFDNLPEL 274
Cdd:TIGR00154 156 --EIITPFEDPpekwVVIAKPHVSVSTPVVYQAYKLPR--NTPKRAKEWLKKISLECLQLLDsngLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|....*
gi 2089723634 275 AALKQRLIDSGnFRSVFMTGSGSTI 299
Cdd:TIGR00154 232 AQALNWLLEYG-LAPERMSGSGPCV 255
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 50-339 8.21e-31

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 118.03  E-value: 8.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  50 FSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMefsTLPYATSDTLECSDPT---IPSDDSNLVIKALNLYRRKTMQ 126
Cdd:PRK14608   10 FAPAKINLALHVTGRRADGYHLLESLVAFADVGDRL---TLEPAEALSLTVSGPFaagLGDGDDNLVLRAARALRARVGP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 127 -TMYFDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAayCTGRGEVVEEVPP 205
Cdd:PRK14608   87 gLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRP--LIMRGIGEELTPL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 206 PVPLETPMLLVKPPVGLSTPRIFKSLDLARRSTADPRVLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLIDSG 285
Cdd:PRK14608  165 PGLPSLPAVLVNPGVPVATPDVFRALGLRDGPPLPGAPDPLASADALLAALAATRNDLEPPALALAPVIGEVLAALRAQP 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 286 NFRSVFMTGSGSTivCFGsesmpaflreeqfkdLFISP------ARLITRKPAGWYTHSG 339
Cdd:PRK14608  245 GALLARMSGSGAT--CFA---------------LFADEaaaeaaAAAIAAAHPGWWVKAT 287
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
47-306 1.73e-29

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 114.08  E-value: 1.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  47 IKLFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEM---EFSTLpyatsdTLECSDPTIPSDDsNLVIKALNLYRRK 123
Cdd:PRK14611    2 EVLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIyikEHHTL------EVKTSSPQIKEEE-NIVYKALRLFERY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 124 TMQTMYFDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGEVVEEV 203
Cdd:PRK14611   75 TGIDINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 204 PPPVPLEtpMLLVKPPVGLSTPRIFKSLDLARRSTADPRVLLAEIAAAKGVDQAAAV--NDLEQPAFDNLPELAALkQRL 281
Cdd:PRK14611  155 EKPISRE--ITLVYPNIKSSTGRVYSKVTKQILTNKEDLNIIISLLREGEEKKIEEVieNTLGEIALELYPEIKEV-YRF 231

                         250       260
                  ....*....|....*....|....*
gi 2089723634 282 IDSGNFRSvFMTGSGSTIVCFGSES 306
Cdd:PRK14611  232 LEYLGYKP-FVSGSGSSVYVFGKPS 255
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 52-300 5.48e-27

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 108.05  E-value: 5.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  52 PSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMefsTLPYATSDTLECSDP---TIPSDDSNLVIKALNLYRRKTMQTM 128
Cdd:PRK03188    6 PAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEV---TVTAADVLSVEVSGEgadQVPTDESNLAWRAAELLAEHVGRAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 129 YFDVKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSNGAAYCTGRGevveevpppvP 208
Cdd:PRK03188   83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRG----------E 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 209 LETPML--------LVKPPVGLSTPRIFKSLDLARRSTADPRV-----LLAEIAAAKGVDQAAA-VNDLEQPAFDNLPEL 274
Cdd:PRK03188  153 QLAPVLargtfhwvLAFADGGLSTPAVFRELDRLREAGDPPRLgepdpLLAALRAGDPAQLAPLlGNDLQAAALSLRPSL 232

                         250       260
                  ....*....|....*....|....*.
gi 2089723634 275 AALKQRLIDSGNFRSVfMTGSGSTIV 300
Cdd:PRK03188  233 RRTLRAGEEAGALAGI-VSGSGPTCA 257
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
49-299 2.04e-14

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 72.62  E-value: 2.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  49 LFSPSKINLFLRVVKRREDGYHDLASLFHVIDLGDEMEFSTLP------YATSDTL----ECSDPTIPSDD--SNLVIKA 116
Cdd:PRK14613    1 MISPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPngvfelFSTNEIIlekrKLYDQVSERGDikQNILYKT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 117 LNLYRRKTMQTMYFDVKLNKRVPHGAGLGGGSGNAATALyaaNRLLG--SPASDEDLLEWSGEIGSDISVFFSNGAAYCT 194
Cdd:PRK14613   81 FIKARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLL---NFLFSwrNFFTSDEMQVFAKEIGSDVPFFLGEGHAFVT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 195 GRGEVVEEVPPPVPLEtpmLLVKPPVGLSTPRIFKSLDLARRSTADPRV--LLAE--IAAAKGVD----QAAAVNDLEQP 266
Cdd:PRK14613  158 GKGEIMEEIEVHKGQG---ILALTPQVMNTGEMYALLKKPLQESASQKNgnTLSEdlISSLKVGDwvslQGRLENDFEPV 234

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2089723634 267 AFDNLPELAALKQRLIDSGnfrSVF--MTGSGSTI 299
Cdd:PRK14613  235 AFQLHPELGVLKDKFLEFG---SSYcsLTGSGSSM 266
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 54-298 1.68e-08

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 54.58  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  54 KINLFLRVVKRReDGYHDLASLF-HVIDLGDEMEF---STLPYATSDTLECSDptipsdDSNLVIKALNLYRRKTMQT-- 127
Cdd:PRK04181    8 KVNIFLKILGKR-GNYHELISRFvLVKDLFDEIEFvpkSAESFELIGNFDCPL------EENIIYKAYQELKNKGFSNel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 128 -MYFD---VKLNKRVPHGAGLGGGSGNAATALYAANRLLGSPASDEDLLEWSGEIGSDISVFFSN-GAAYCTGRGEVVEE 202
Cdd:PRK04181   81 iEFFKkkaIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 203 VPPPVpletPML-LVKPPVGLSTPRIFKSLD---LARRSTADPRVLLA----EIAAAKGvdqAAAVNDLEQPAFDNLPEL 274
Cdd:PRK04181  161 FEEEI----LNLeIFTPNIFCSTKAVYKAYReefYDFISFNQAKELLKlsslELLKNFK---NTELNDLLAPALKLYPAL 233

                         250       260
                  ....*....|....*....|....
gi 2089723634 275 AALKQrlidsgnfRSVFMTGSGST 298
Cdd:PRK04181  234 KDYLG--------EDWFFSGSGSS 249
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
51-302 2.44e-08

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 54.08  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  51 SPSKINLFLRVVKRRED-GYHDLASLFHVI-DLGDEMEFsTLPYATSDTLECSDPT----IPSDDsnLVIKALNLYRRKT 124
Cdd:PRK05905    5 SYAKINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEI-EKIEKNIDDIHYFDETneilVYSRL--ILVKTLEWLRDKY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 125 MQTMYFDVKLNKRVPHGAGLGGGSGNAATALYAANRLLG-SPASDEDLLEwsgEIGSDISVFFSN-GAAYCTGRGEVVEE 202
Cdd:PRK05905   82 NIKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEFEGiNEINYKDVVN---KLGSDIPFFLSGyKTAYISDYGSQVED 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 203 VPPPVPLETPMLLVKppVGLSTPRIFKSLDLARRSTADPrvLLAEIAAAKGVDQAAAVNDLEQPAFDNLPELAALKQRLI 282
Cdd:PRK05905  159 LIGQFKLTYKVIFMN--VNVSTKKVFEKFDDNQHVIKNN--FKTIIKNLKENIVVNIHNDLQEPCFELYPNLLYKYNELL 234

                         250       260
                  ....*....|....*....|
gi 2089723634 283 DSGNFrsVFMTGSGSTIVCF 302
Cdd:PRK05905  235 NDGFY--TILSGAGSSFIVI 252
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 79-178 6.36e-07

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 50.10  E-value: 6.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634  79 IDLGDEMEFSTLPyatSDTLE-----CSDPTIPSDDSNLVIKALNLYRRKTMQTMY-FDVKLNKRVPHgaglgggsgnaa 152
Cdd:COG0083    25 LSLYDEVEVERSD---EPGLEieiegEGADELPTDEDNLVYQAALALLEKLGKEPPgLRIEIEKGIPL------------ 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2089723634 153 T------------ALYAANRLLGSPASDEDLLEWSGEI 178
Cdd:COG0083    90 GrglgssaaaivaGLVAANALLGLPLSKEELLELATEG 127
PRK01212 PRK01212
homoserine kinase; Provisional
 105-178 3.39e-04

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 41.67  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723634 105 IPSD-DSNLVIKALNLYRRKTMQTMYFDVKLNKRVPHgaglgggsgnaaT------------ALYAANRLLGSPASDEDL 171
Cdd:PRK01212   56 LPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPL------------GrglgssaasivaGLVAANELAGLPLSKEEL 123


                  ....*..
gi 2089723634 172 LEWSGEI 178
Cdd:PRK01212  124 LQLATEG 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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