|
Name |
Accession |
Description |
Interval |
E-value |
| mrcB |
PRK09506 |
bifunctional glycosyl transferase/transpeptidase; Reviewed |
1-840 |
0e+00 |
|
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain] Cd Length: 830 Bit Score: 1617.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 1 MAGNDREPIGRKGKPTRPVKQKVSRRQLRDDEYDDEYDDDYEDEePMPRKGKGKGRKPRGKRGWLWLLLKIAIVFAVLLA 80
Cdd:PRK09506 1 MAGNDREPIGRKGKPSRPVKQKVSRRRYRDDDDYDDYDDYEDEE-PMPRKGKGKGRKPRGKRGWLWLLLKLFIVFAVLIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 81 IYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPEMSVSKNEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDF 160
Cdd:PRK09506 80 IYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPGMSYSKNEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 161 PDSKEGQVRARLTFDGGRLDTIVNMDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHD 240
Cdd:PRK09506 160 PDSKEGQVRARLTFDGDRLATIVNLDNNRQFGFFRLDPRLITMLQSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 241 GVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALLMDARYSKDRILELYMNEVYLGQSGD 320
Cdd:PRK09506 240 GISLYSIGRAVLANLTAGRTVQGGSTLTQQLVKNLFLSNERSLWRKANEAYMALIMDARYSKDRILELYLNEVYLGQSGD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 321 NEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGV 400
Cdd:PRK09506 320 DQIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALERRNLVLRLLQQQQIIDQELYDMLSARPLGV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 401 QPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAAVDGIPELKKQRKLSDLETAIVVVDRFS 480
Cdd:PRK09506 400 QPKGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTLDPVSQDAAEKAVEEGIPALKKQRKLSDLETAMVVVDRFS 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 481 GEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQVWSPQNDDRRYseSG 560
Cdd:PRK09506 480 GEVRAMVGGSEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPDKYRLNTWIADAPISLRQPNGQVWSPQNDDRRF--SG 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 561 KVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLGVPKEQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALR 640
Cdd:PRK09506 558 RVMLVDALTRSMNVPTVNLGMALGLPAVTDTWIKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALR 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 641 SVIAEDGTVLYQSFPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTIT 720
Cdd:PRK09506 638 SVIAEDGKVLYQSFPQAERAVPAQAAYLTLYTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNDLVDSWFAGIDGKEVTIT 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 721 WVGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLTLTPPEDIAEMGVDYDGNFVCSG-GMRTLPVWTSDPDSLCQQGEMM 799
Cdd:PRK09506 718 WVGRDNNQPTKLYGASGAMTIYQRYLENQTPTPLNLTPPEDIVDMGVDYDGNFVCGSgGMRVLPVWTDDPQSLCQQSEMQ 797
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 2082058632 800 QQPtgnpfdqssQPQQPQQQPPKEEKKDSDGVAGWIKDMFG 840
Cdd:PRK09506 798 QQP---------SQPQQQPQQQPAEQKDSDGVAGWIKDMFG 829
|
|
| PBP_1b |
TIGR02071 |
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) ... |
66-794 |
0e+00 |
|
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273952 [Multi-domain] Cd Length: 730 Bit Score: 1289.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 66 WLLLKIAIVFAVLLAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPEMSVSKNEMVKLLEATQYRQVSKMTRPGEFT 145
Cdd:TIGR02071 1 GFLLKLAFTAAVLLAFYGLYLDQQIRSRFDGKVWQLPAAVYARPLNLEPGMSLSKKELLIELDATQYRQVSHVTLPGEYS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 146 VQANSIEMIRRPFDFPDSKEGQVRARLTFDGGRLDTIVNMDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLV 225
Cdd:TIGR02071 81 VQNNSIEVIRRPFDFPDGAEPQRRARLTFNGNQLSKIENLDNNKEFGFFRLDPKLIAMLYSPNGEQRLFVPRDQFPELLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 226 DTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALLMDARYSKDRI 305
Cdd:TIGR02071 161 DTLLATEDRDFYEHDGISLYSIGRAVWVNLTAGRTVQGGSTLTQQLVKNLFLSNERSLWRKANEAYMALILDARYSKDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 306 LELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQVI 385
Cdd:TIGR02071 241 LELYLNEVYLGQSGDDAIHGFPLASQYYFGRPLGELSLDQVALLVGMVKGPSYYNPWRNPDRALERRNLVLRLLQEQKII 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 386 DQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAAVDGIPELKKQRK 465
Cdd:TIGR02071 321 DDEEYDMLSARPLGVQKKGGIISRQPAFLQLVRRELRQKLGDKVKDLSGLRIFTTLDPVSQSAAEQAVQETIPALKKKKK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 466 LSDLETAIVVVDRFSGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQ 545
Cdd:TIGR02071 401 LPDLEAAMVVTDRFTGEVRAMVGGSDPQFAGFNRALQARRQIGSLVKPAVYLTALSQPDKYRLNTWIEDQPLSIKLSNGQ 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 546 VWSPQNDDRRYseSGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLGVPKEQLHPVPAMLLGALNLTPIEVAQAFQ 625
Cdd:TIGR02071 481 VWSPQNYDRRY--SGTVMLYDALAHSLNIPTVNLGMKVGLPKVSQTWNKLGINKDEIPPVPSMLLGAINLTPYEVAQLYQ 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 626 TIASGGNRAPLSALRSVIAEDGTVLYQSFPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNV 705
Cdd:TIGR02071 559 TIASGGNRAPLSAVRSVLDEDGKVLYQSDPQAEQAVPSQAAYLTLYAMQQVVQRGTARSLGADFPSLSLAGKTGTTNDNR 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 706 DTWFAGIDGSQVTITWVGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLTLTPPEDIAEMGVDYDGNFVCS---GGMRTL 782
Cdd:TIGR02071 639 DSWFAGIDGKEVTIIWLGRDDNGPTKLTGASGALQVYARYLSYQTPEPLLLVPPEGIDWFGVDPQGNGGCKancPGARRL 718
|
730
....*....|..
gi 2082058632 783 PVWTSDPDSLCQ 794
Cdd:TIGR02071 719 PIWTGNPQALCQ 730
|
|
| PRK14850 |
PRK14850 |
penicillin-binding protein 1b; Provisional |
68-795 |
0e+00 |
|
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain] Cd Length: 764 Bit Score: 1014.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 68 LLKIAIVFAVLLAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPEMSVSKNEMVKLLEATQYRQVSKMTRPGEFTVQ 147
Cdd:PRK14850 13 LIYVFFFVLLLILCYGVYLYVKINRFINGKVWNFPTSIYSRIVNLEPGNSYSQKDVIHLLKSTMYRKVDLVTLPGEFSVK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 148 ANSIEMIRRPFDFPDSKEGQVRARLTFDGGRLDTIVNMDNNRQFGFFRLDPRLITMLSSPNGEQRLFVPRSGFPDLLVDT 227
Cdd:PRK14850 93 NNTIELIRRSFDFPDIREDEIHARLYFNKDKLVRIKNIDNNHDFSFLRLDPKLIAMLYSPEGKKRLFIPRNQYPEMLIKT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 228 LLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALLMDARYSKDRILE 307
Cdd:PRK14850 173 LLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTIQGGSTLTQQLVKNLFLTNTRSLWRKINEIYMALILDRFYSKDRILE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 308 LYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQVIDQ 387
Cdd:PRK14850 253 LYLNEVYLGQDGNEQIRGFPLASIYYFGRPINELNLDQYALLVGMVKGASLYNPWTNPNLTLKRRNLVLFLLYKQKVITR 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 388 ELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAAVDGIPELKKQRKLS 467
Cdd:PRK14850 333 KLYKDLCSRPLNVQSKGNIISSHPAFIQLVCEEFHKKIHYPFKNFSGTKIFTTLDYISQNAAEQAVKIGIPILKRKKRLK 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 468 DLETAIVVVDRFSGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQVW 547
Cdd:PRK14850 413 DLEVAMVIIDRFSGEVRALIGSSKPEFNGYNRALKARRSIGSLSKPITYLTALSQPEKYHLNTWISDTPISIKLDNGQYW 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 548 SPQNDDRRYseSGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLGVPKEQLHPVPAMLLGALNLTPIEVAQAFQTI 627
Cdd:PRK14850 493 TPKNNNFSF--SGKVMLIDALIHSINIPTVHLSINLGLKKLVDSWILLGISSNYITPLPSISLGAINLTPMEVAQVFQII 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 628 ASGGNRAPLSALRSVIAEDGTVLYQSFPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNVDT 707
Cdd:PRK14850 571 GSGGYKSSLSSIRSIISDDNKVLYQNFPQSKHVESSQASYLTLYAMQQVVKSGTAKSLGTIFKEFSLAGKTGTTNNLVDS 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 708 WFAGIDGSQVTITWVGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLTLTPPEDIAEMGVDYDGNFVC----SGGMRTLP 783
Cdd:PRK14850 651 WFVGIDGKQVVITWIGRDNNHTTKLYGSSGAMKIYKRYLQYQNPVPLVLKAPNNINMFYINNLGELFCkkgnNQYNRMLP 730
|
730
....*....|..
gi 2082058632 784 VWTSDPDSLCQQ 795
Cdd:PRK14850 731 IWSINNKKICND 742
|
|
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
179-747 |
0e+00 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 666.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 179 LDTIVNMDNNRQFGFFRLDPRLITMLSspnGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAG 258
Cdd:COG0744 44 PEELEDLALPQTSTIYDRDGTLIATLG---DENREWVPLDQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARALVANLTAG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 259 RTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMALLMDARYSKDRILELYMNEVYLGQSgdneIRGFPLASLYYFGRPV 338
Cdd:COG0744 121 GVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLERKYSKDEILELYLNTVYFGRG----AYGIEAAAQYYFGKSA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 339 EELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQP--RGGVISPQPAFMQM 416
Cdd:COG0744 197 SDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLVPppNGAAAGKYPYFVDY 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 417 VRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAAVDGIPElkkqRKLSDLETAIVVVDRFSGEVRAMVGGAEPQFAG 496
Cdd:COG0744 277 VRRELEELLGEDDLYRGGLKIYTTLDPKLQKAAEKAVKNVLPE----GKPGGLQAALVVVDPKTGEVLAMVGGRDYGKSQ 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 497 YNRAMQARRSIGSLAKPATYLTALSQPkiYRLNTWIADAPIALrqpNGQVWSPQNDDRRYseSGKVMLVDALTRSMNVPT 576
Cdd:COG0744 353 FNRATQAKRQPGSTFKPFVYAAALEQG--YTPATTVDDEPVTF---PGGGWSPKNYDGRY--RGPVTLREALANSLNTPA 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 577 VNLGMALGLPAVTDTWLKLGVPKEqLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSFPQ 656
Cdd:COG0744 426 VRLAQEVGLDKVVDTARRLGITSP-LDPNPSLALGTSEVSPLEMASAYATFANGGVYVEPHAITKVTDADGKVLYEAKPK 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 657 AERAVPAQAAYMTLWTMQQVVQRGTGRqlGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPTK-LYGA 735
Cdd:COG0744 505 CEQVISPEVAYLMTDMLQDVVTSGTGR--AARLPGRPVAGKTGTTNDNRDAWFVGYTPQLVTAVWVGNDDNSPMGyVTGG 582
|
570
....*....|..
gi 2082058632 736 SGAMSIYQRYLA 747
Cdd:COG0744 583 SLPAPIWRDFME 594
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
211-747 |
1.46e-152 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 457.49 E-value: 1.46e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 211 QRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEA 290
Cdd:TIGR02074 1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLYLTNERTITRKIQEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 291 YMALLMDARYSKDRILELYMNEVYLGQsGDNeirGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALE 370
Cdd:TIGR02074 81 LLALKLEQKLSKDEILELYLNRIYFGN-GAY---GIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 371 RRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGvISPQ---PAFMQMVRQELQAKLGDKVKDlSGVKIFTTFDSVAQD 447
Cdd:TIGR02074 157 RRNLVLSNMVENGYITAEEAEEAINEPIQLYLQTK-KSEQykaPYFVDYVIQELEEEYGEELYT-GGLKIYTTLDLDAQK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 448 AAEKAAVDGIPELKKQRKLsDLETAIVVVDRFSGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSqpKIYR 527
Cdd:TIGR02074 235 AAEKVLNTGLRVAGRRDGD-DLQAALVAIDPDTGAVRALVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALE--KGLT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 528 LNTWIADAPIALrQPNGqVWSPQNDDRRYseSGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLGVpKEQLHPVPA 607
Cdd:TIGR02074 312 PATIVNDEPITY-NGNG-PWSPKNYGGGY--RGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI-TSPLDPVLS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 608 MLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSFPQAERAVPAQAAYMTLWTMQQVVQRGTGRqlGA 687
Cdd:TIGR02074 387 LALGTVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVIYENKPKTTQVISPATAYIMTDMLKGVVESGTGR--SA 464
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2082058632 688 KYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPTKL--YGASGAMSIYQRYLA 747
Cdd:TIGR02074 465 RLPGRPVAGKTGTTQNWRDAWFVGYTPYYVTAVWVGYDDKKTLGKsgTGGGLAAPIWRDFMA 526
|
|
| MrcA |
COG5009 |
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis]; |
210-745 |
1.15e-148 |
|
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain] Cd Length: 785 Bit Score: 456.16 E-value: 1.15e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 210 EQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANE 289
Cdd:COG5009 64 ERRIPVPIEEIPPLLINAFLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKNFLLSPERTLTRKIKE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 290 AYMALLMDARYSKDRILELYMNEVYLGQsgdneiR--GFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKL 367
Cdd:COG5009 144 AILALRIEQELSKDEILELYLNKIYLGH------RayGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPER 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 368 ALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGVISPQ-PAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQ 446
Cdd:COG5009 218 ALERRNYVLGRMLELGYITQAEYEAAKAEPLTARYHGASAEVDaPYFAEMVRRELVERYGEDALYTGGLKVYTTLDPRLQ 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 447 DAAEKAAVDGI-----------PE-------------LKKQRKLSDL--------------------------------- 469
Cdd:COG5009 298 EAAEKALRDGLlaydrrhgyrgPEahldlaeedwdeaLAEVPDVGDLrpavvlevddksarvglrdgetgtlpleglkwa 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 470 --------------------------------------------ETAIVVVDRFSGEVRAMVGGAEPQFAGYNRAMQARR 505
Cdd:COG5009 378 rpyindnrrgpapksasdvlkpgdvirvrpvadggwrlrqipevQGALVALDPHTGAVLALVGGFDFEQSKFNRATQAKR 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 506 SIGSLAKPATYLTALSqpKIYRLNTWIADAPIALRQP-NGQVWSPQNDDRRYseSGKVMLVDALTRSMNVPTVNLGMALG 584
Cdd:COG5009 458 QPGSSFKPFVYAAALD--NGYTPATIINDAPIVFDDGgGGGVWRPKNYSGKF--YGPTTLREALEKSRNLVTVRLLQDVG 533
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 585 LPAVTDTWLKLGVPkEQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSFPQ-------- 656
Cdd:COG5009 534 IDYVIDYAERFGIY-SKLPPNLSLALGSGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADPAracedcda 612
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 657 -------------AERAVPAQAAYMTLWTMQQVVQRGTGRqlGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVG 723
Cdd:COG5009 613 aewdgaeprlpdpAEQVIDPRTAYQMTSMLRGVVQRGTGR--RARALGRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVG 690
|
650 660
....*....|....*....|....
gi 2082058632 724 RDNNQP--TKLYGASGAMSIYQRY 745
Cdd:COG5009 691 FDDPRSlgRGETGGRAALPIWIDF 714
|
|
| PbpC |
COG4953 |
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ... |
206-738 |
4.24e-84 |
|
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain] Cd Length: 773 Bit Score: 285.19 E-value: 4.24e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 206 SPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKnLFLSSERSYWR 285
Cdd:COG4953 59 AADGQWRLPVPLDEVSPRYLQALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVAR-LLEPRPRTLSG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 286 KANEAYMALLMDARYSKDRILELYMNEVYLGqsgdNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNP 365
Cdd:COG4953 138 KLRQILRALQLERRYSKDEILELYLNLAPYG----GNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRPDRNP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 366 KLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGvisPQ--PAFMQMVRQELQAklgdkvkdlsGVKIFTTFDS 443
Cdd:COG4953 214 ERARAARDRVLARLAEAGVIDAEEAALALLEPVPARRRPL---PQlaPHLARRLLRQLPG----------GTRIRTTLDA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 444 VAQDAAEKAAVDGIPELKKQRKLSdleTAIVVVDRFSGEVRAMVGGA---EPQFAGYNRAMQARRSIGSLAKPATYLTAL 520
Cdd:COG4953 281 GLQRRLERLVRRYVRRLKQNGIHN---AAVLVVDNRTGEVLAYVGSAdffDASRQGQVDMVRALRSPGSTLKPFLYGLAL 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 521 SQ----PkiyrlNTWIADAPialRQPNGqvWSPQNDDRRYseSGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLG 596
Cdd:COG4953 358 DQglihP-----ETLLADVP---TSFGG--YRPENFDGTF--QGPVSAREALARSLNIPAVRLLEALGPARFYARLRRAG 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 597 VP---KEQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSviaedgtvlyQSFPQAERAVPAQAAYMTLWTM 673
Cdd:COG4953 426 LRlllPPAEHYGLSLILGGAEVTLEELVGLYAALARGGEARPLRLLAG----------EPASPGRRLLSPGAAWLVRDIL 495
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2082058632 674 QQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPTK-LYGASGA 738
Cdd:COG4953 496 SDVPRPDGAFGWRALDSPPPIAWKTGTSYGFRDAWAVGFTGRYTVGVWVGNPDGTPVPgLTGAEAA 561
|
|
| PBP_1c |
TIGR02073 |
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ... |
197-743 |
3.90e-76 |
|
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273954 [Multi-domain] Cd Length: 727 Bit Score: 262.36 E-value: 3.90e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 197 DPRLITMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLF 276
Cdd:TIGR02073 18 HGTLLRALLANDGQWRLPVPLEDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNGRRVSGGSTLTMQLARLLD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 277 LSSERSYWRKANEAYMALLMDARYSKDRILELYMNevyLGQSGDNeIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGA 356
Cdd:TIGR02073 98 PELSRTLTGKLRQMWRAIQLEARYSKREILEAYLN---LAPYGGN-LEGLRAASLIYFGKEPSSLSLAEAALLAALPQAP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 357 SIYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGgviSPQ--PAFMQMVRQELQAKLGdkvkdlsg 434
Cdd:TIGR02073 174 SARRLDRLPKAAKAARDRLLDRMVEQGPDDSEQVALAALEPLPALPEP---LPQlaPHFALKLLRARPEIAS-------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 435 vKIFTTFDSVAQDAAEKAAVDgipELKKQRKLSDLETAIVVVDRFSGEVRAMVGGAE---PQFAGYNRAMQARRSIGSLA 511
Cdd:TIGR02073 243 -VIVSTLDADLQRRLEELARR---YLSALRPRGISNLAILVVDNRSGAVLAYVGSADffdDSNSGQVDGVRAPRSPGSTL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 512 KPATYLTALSQPKIYRlNTWIADAPIALrqpngQVWSPQNDDRRYSesGKVMLVDALTRSMNVPTVNLGMALGLPAVTDT 591
Cdd:TIGR02073 319 KPFLYALALDDGLLHP-DSLLKDVPLRF-----GDYAPENFDKTFH--GPVPAREALARSLNIPAVRLLERVGPPRFADF 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 592 WLKLGVP---KEQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSViaedgtvlyQSFPQAERAVPAQAAYM 668
Cdd:TIGR02073 391 LRQAGLNllkPKSDYYGLSLALGGAEITLQDLANLYAMLANQGLSGPLRFLQTD---------AKRPERERLLSPGAAWI 461
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2082058632 669 TLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQPT-KLYGASGAMSIYQ 743
Cdd:TIGR02073 462 VLDILKDRPRPDDTLPLSALPTRLPLAWKTGTSYGFRDAWAAGVSGRYTIGVWVGNFDGKPNpGFFGAAAAAPLLF 537
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
202-373 |
1.72e-73 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 237.81 E-value: 1.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 202 TMLSSPNGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSER 281
Cdd:pfam00912 3 TLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLFLTPER 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 282 SYWRKANEAYMALLMDARYSKDRILELYMNEVYLGqsgdNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNP 361
Cdd:pfam00912 83 TLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFG----RGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNP 158
|
170
....*....|..
gi 2082058632 362 WRNPKLALERRN 373
Cdd:pfam00912 159 LRNPERAKRRRN 170
|
|
| mrcA |
PRK11636 |
penicillin-binding protein 1a; Provisional |
209-726 |
4.10e-57 |
|
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain] Cd Length: 850 Bit Score: 210.76 E-value: 4.10e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 209 GEQR-LFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKA 287
Cdd:PRK11636 62 GEKRrIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKI 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 288 NEAYMALLMDARYSKDRILELYMNEVYLGqsgdNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKL 367
Cdd:PRK11636 142 KEAFLAIRIEQLLTKDEILELYLNKIYLG----YRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAPSTFNPLYSMDR 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 368 ALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGVIS-PQPAFMQMVRQELQAKLGDKVKDlSGVKIFTTFDSVAQ 446
Cdd:PRK11636 218 AVARRNVVLSRMLDEGYITQAQYDQARSEPIVANYHAPEIAfSAPYLSEMVRQEMYNRYGENAYE-DGYRVYTTITRKVQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 447 DAAEKAAVDG------------------------------IPELKKQ--------------------------------- 463
Cdd:PRK11636 297 QAAQQAVRNNvldydmrhgyrgpanvlwkvgesawdnkkiTDTLKALptygpllpavvtsanpqeatamladgssvalpm 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 464 ----------------------------------RK---------LSDLETAIVVVDRFSGEVRAMVGGAEPQFAGYNRA 500
Cdd:PRK11636 377 egvrwarpyrsdtqqgptprkvtdvvqtgqqiwvRQvddawwlaqVPDVNSALVSINPQNGAVMALVGGFDFNQSKFNRA 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 501 MQARRSIGSLAKPATYLTALSqpKIYRLNTWIADAPIALRQPN-GQVWSPQNDDRRYseSGKVMLVDALTRSMNVPTVNL 579
Cdd:PRK11636 457 TQALRQVGSNIKPFLYTAAMD--KGLTLASMLNDVPISRWDAGaGSDWRPKNSPPQY--AGPIRLRQGLGQSKNVVMVRA 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 580 GMALGLPAVTDTWLKLGVPKEQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQS------ 653
Cdd:PRK11636 533 MRAMGVDYAAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIFEAkpkvac 612
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 654 --------------------------------------FPQAERAVPAQAAymtlwtmQQVVQR---------------- 679
Cdd:PRK11636 613 pecdipviygdtqksnvlenddvenvatsqeqqnssvpMPQLEQANQALVA-------QNGAQEyaphvintplafliks 685
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 680 -------------GTGRQLGAKYPNLHLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDN 726
Cdd:PRK11636 686 alntnifgepgwmGTGWRAGRDLKRRDIGGKTGTTNSSKDAWFSGYGPGVVTSVWIGFDD 745
|
|
| mono_pep_trsgly |
TIGR02070 |
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ... |
211-364 |
1.70e-33 |
|
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273951 [Multi-domain] Cd Length: 224 Bit Score: 128.73 E-value: 1.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 211 QRLFVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEA 290
Cdd:TIGR02070 54 QHRWRPYDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDALEKNEKSGKVVRGGSTISQQLAKNLFLWSGRSYLRKGLEA 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2082058632 291 YMALLMDARYSKDRILELYMNEVYLGqsgdNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRN 364
Cdd:TIGR02070 134 WATWMLETWWSKQRILEVYLNSVEWG----NGVFGAEAAARYYFKRSASNLTRGQAARLAAVLPNPKYYDENRP 203
|
|
| UB2H |
pfam14814 |
Bifunctional transglycosylase second domain; UB2H is the second domain of the ... |
112-196 |
1.45e-29 |
|
Bifunctional transglycosylase second domain; UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle.
Pssm-ID: 434234 [Multi-domain] Cd Length: 85 Bit Score: 112.27 E-value: 1.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 112 LEPEMSVSKNEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRARLTFDGGRLDTIVNMDNNRQF 191
Cdd:pfam14814 1 LYPGQALSAAQLEQELKLLGYRKVSNPTRPGEYSVSGNRIELYRRGFDFPDGAEPARRVRLRFAGGRVARLQDLDTGRDL 80
|
....*
gi 2082058632 192 GFFRL 196
Cdd:pfam14814 81 ALVRL 85
|
|
| PRK13481 |
PRK13481 |
glycosyltransferase; Provisional |
214-360 |
7.23e-26 |
|
glycosyltransferase; Provisional
Pssm-ID: 184078 [Multi-domain] Cd Length: 232 Bit Score: 106.81 E-value: 7.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 214 FVPRSGFPDLLVDTLLATEDRHFYEHDGVSLYSIGRAVLANLtAGRTVQGASTLTQQLVKNLFLSSERSYWRKANEAYMA 293
Cdd:PRK13481 47 FVSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTI-SDRDVQGGSTITQQVVKNYFYDNERSFTRKVKELFVA 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2082058632 294 LLMDARYSKDRILELYMNEVYLgqsGDNE--IRGfplASLYYFGRPVE-------ELSLDQQALLVGMVKGASIYN 360
Cdd:PRK13481 126 HRVEKQYSKNEILSFYLNNIYF---GDNQytLEG---AANHYFGTTVNknsttmsHITVLQSAILASKVNAPSVYN 195
|
|
| PRK11240 |
PRK11240 |
penicillin-binding protein 1C; Provisional |
228-729 |
7.68e-26 |
|
penicillin-binding protein 1C; Provisional
Pssm-ID: 183049 [Multi-domain] Cd Length: 772 Bit Score: 114.03 E-value: 7.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 228 LLATEDRHFYEHDGVSLYSIGRAVLANLTAGRTVQGASTLTQQlVKNLFLSSERSYWRKANEAYMALLMDARYSKDRILE 307
Cdd:PRK11240 78 LINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQ-VARLLDPHPRTFGGKIRQLWRALQLEWHLSKREILT 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 308 LYMNEVYLGQSgdneIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQVIDQ 387
Cdd:PRK11240 157 LYLNRAPFGGT----LQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRPDRWPERAEAARNKVLERMAEQGVWSA 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 388 ELYDMLSARPLGVQPRGgviSPQ--PAFMQMVrqelqaklgdkVKDLSGVKIFTTFDSVAQDAAEKAAVDGIPELKKQRK 465
Cdd:PRK11240 233 EQVKESREEPVWLAPRQ---MPQlaPLFARMM-----------LGKSKSDKIVTTLDAGLQRRLEDLALNWKGRLPPRSS 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 466 LsdletAIVVVDRFSGEVRAMVGGA----EPQFaGYNRAMQARRSIGSLAKPATYLTALSQPKIYRlNTWIADAPialRQ 541
Cdd:PRK11240 299 L-----AMIVVDHTDMAVRGWVGSVdlndDSRF-GHVDMVNAIRSPGSVLKPFVYGLALDDGLIHP-ASLLQDVP---RR 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 542 PNGqvWSPQNDDRRYseSGKVMLVDALTRSMNVPTV----------------NLGMALGLPAVTDtwlklgvpkeqlhPV 605
Cdd:PRK11240 369 TGD--YRPGNFDSGF--HGPVSMSEALVRSLNLPAVqvleaygpkrfaaklrNVGLPLYLPAGAE-------------PN 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 606 PAMLLGALNLTPIEVAQAFQTIASGGNRAPLSalrsviaedgtvLYQSFPQAERAV-PAQAAYMTLWTMQQVVQRGTGRQ 684
Cdd:PRK11240 432 LSLILGGAGARLEDMVAAYSAFARHGKAAKLR------------LQPDDPLLERPLmSPGAAWIIRRIMADEAQPLPDAA 499
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 2082058632 685 LGAKYPnlhLAGKTGTTNNNVDTWFAGIDGSQVTITWVGRDNNQP 729
Cdd:PRK11240 500 LPRVVP---LAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTP 541
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
472-736 |
2.14e-23 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 101.34 E-value: 2.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 472 AIVVVDRFSGEVRAMVGG-----AEPQFAGYNRAMQARRSIGSLAKPATYLTALSQpKIYRLNTWIADAPIalRQPNGQV 546
Cdd:pfam00905 2 SAVVLDPKTGEVLAMVGKpsydpNGFIGPLRNRAVTSRYEPGSTFKPFTALAALDN-GVLKPDETIFDWPG--KQQGGKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 547 WSPQNDDRryseSGKVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLG----------------VPKEQLHPVPAMLL 610
Cdd:pfam00905 79 IGDWNQDQ----VGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGygnktgiglpgenagyLTPYWLEGATASFG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 611 GALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDgtvlyQSFPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKyP 690
Cdd:pfam00905 155 IGLTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKV-----DPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTGTAAV-P 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 691 NLHLAGKTGTT-----------NNNVDTWFAGI---DGSQVTITWVgrdNNQPTKLYGAS 736
Cdd:pfam00905 229 GYKVAGKTGTAqvagpkgggyyDGAQIGWFVGYapaDNPKYAFAVL---IDDPKRYYGGK 285
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
425-712 |
9.96e-22 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 100.28 E-value: 9.96e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 425 LGDKVKDLSGVKIFTTFDSVAQDAAEKAavdgipeLKKQRKLSDLET-AIVVVDRFSGEVRAMV------------GGAE 491
Cdd:COG0768 209 LGEEKPPVPGKDLVLTIDSDLQKIAEEA-------LKKAVEEYKAKSgAVVVMDPKTGEILAMAsypsfdpnlfvgGPDE 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 492 PQFagyNRAMQARRSIGSLAKPATYLTALSQpKIYRLNTWIADapialrqpNGQVwspQNDDRRYSES-----GKVMLVD 566
Cdd:COG0768 282 PLR---NRAVQGTYEPGSTFKPFTAAAALEE-GVITPDTTFDC--------PGYY---RVGGRTIRDWdrgghGTLTLTE 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 567 ALTRSMNVPTVNLGMALGLPAVTDTWLKLG----------------VP-KEQLHPVPAMLLG---ALNLTPIEVAQAFQT 626
Cdd:COG0768 347 ALAKSSNVGFYKLALRLGIDKLYDYLKKFGlgqktgidlpgeasglLPsPKRWYPGETATMSigqGLSVTPLQLAQAYAA 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 627 IASGGNRAPLSALRSVIAEDGTVLYQSFPQAERAVPAQAAYMTLWTMQQVVQ--RGTGRqlGAKYPNLHLAGKTGT---- 700
Cdd:COG0768 427 IANGGVLVKPHLVKEIVDPDGEVVKEEPEVLRRVISPETAETVREGMEGVVNepGGTAR--RAAIPGYRVAGKTGTaqvv 504
|
330
....*....|....*....
gi 2082058632 701 -------TNNNVDTWFAGI 712
Cdd:COG0768 505 dignggyYKGRHIASFVGF 523
|
|
| PBP1_TM |
pfam14812 |
Transmembrane domain of transglycosylase PBP1 at N-terminal; This is the N-terminal, ... |
1-78 |
1.15e-19 |
|
Transmembrane domain of transglycosylase PBP1 at N-terminal; This is the N-terminal, transmembrane, domain of the transglycosylases ()penicillin-binding proteins), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The TM domain is a single helix, several of whose residues lie in close proximity to hydrophobic residues in the TGT domain. The TM helix seems to be necessary for stabilizing the protein-membrane interaction, and the resulting orientation limits the interaction between PBPb1 and lipid II in the membrane in a 2D lateral diffusion fashion.
Pssm-ID: 434232 Cd Length: 85 Bit Score: 84.06 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 1 MAGNDREPIGRKGKPT--RPVKQKVSRRQLR------DDEYDDEYDDDYEDEEPMPRKGKGkGRKPRGKRGWLWLLLKIA 72
Cdd:pfam14812 1 MSGDDREPIGRKGKKSgrKPPRKRASRRRRRdddyddEYDDDYDDDDDDDEEEPMPRKGKG-GRPPRKKRRWLWLLIKLF 79
|
....*.
gi 2082058632 73 IVFAVL 78
Cdd:pfam14812 80 LVFAVL 85
|
|
| pbp2_mrdA |
TIGR03423 |
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ... |
427-700 |
6.53e-10 |
|
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain] Cd Length: 592 Bit Score: 62.54 E-value: 6.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 427 DKVKDLSGVKIFTTFDSVAQDAAEKAavdgipeLKKQRklsdleTAIVVVDRFSGEVRAMV--------------GGAE- 491
Cdd:TIGR03423 218 SRVPPVPGKDLVLTIDARLQQAAEKA-------LGGRR------GAVVVMDPRTGEILAMVstpsfdpnlfvdgiSSKDy 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 492 ------PQFAGYNRAMQARRSIGSLAKPATYLTALsQPKIYRLNTWIADaPIALRQPNgQVWspqNDDRRYSEsGKVMLV 565
Cdd:TIGR03423 285 kallndPDRPLLNRAIQGVYPPGSTFKPVVALAAL-EEGVITPETRIYC-PGYFQLGG-RRF---RCWKRGGH-GRVDLR 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 566 DALTRSMNVPTVNLGMALGLPAVTDTWLKLG----------------VP----KEQLHP---VPAMLL------GALNLT 616
Cdd:TIGR03423 358 KAIEESCDVYFYQLALRLGIDKIAEYAKRFGfgqktgidlpgeksglVPsrewKRKRFGqpwYPGDTLnvsigqGYVLVT 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 617 PIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSFPQAERAVPAQAAYmtlW-----TMQQVVQ--RGTGR--QLGA 687
Cdd:TIGR03423 438 PLQLAVATAALANGGKLYKPHLVKSIEDPDGGVVRRTEPEVLRPLPISPEN---LdvvreGMRDVVNgpGGTARraRLGL 514
|
330
....*....|...
gi 2082058632 688 KYPnlhLAGKTGT 700
Cdd:TIGR03423 515 PYK---MAGKTGT 524
|
|
| PRK15105 |
PRK15105 |
peptidoglycan synthase FtsI; Provisional |
474-700 |
7.71e-05 |
|
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain] Cd Length: 578 Bit Score: 46.35 E-value: 7.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 474 VVVDRFSGEVRAMVGG---------AEPQFAGYNRAMQARRSIGSLAKPATYLTALsQPKIYRLNTWIADAPIALrqpNG 544
Cdd:PRK15105 262 VLVDVNTGEVLAMANSpsynpnnlsGTPKDAMRNRAITDVFEPGSTVKPMVVMTAL-QRGVVKENSVLNTVPYRI---NG 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 545 QvwsPQNDDRRYSEsgkVMLVDALTRSMNVPTVNLGMALGLPAVTDTWLKLGVPKeqlhPVPAMLLG------------- 611
Cdd:PRK15105 338 H---EIKDVARYSE---LTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGK----ATNLGLVGersglypqkqrws 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082058632 612 -----------ALNLTPIEVAQAFQTIASGGNRAPLSALRSviaeDGTVlyqsfpQAERAVPAQAAYMTLWTMQQVVQRG 680
Cdd:PRK15105 408 dieratfsfgyGLMVTPLQLARVYATIGSYGIYRPLSITKV----DPPV------PGERVFPESIVRTVVHMMESVALPG 477
|
250 260
....*....|....*....|
gi 2082058632 681 TGrQLGAKYPNLHLAGKTGT 700
Cdd:PRK15105 478 GG-GVKAAIKGYRIAIKTGT 496
|
|
| |
