NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2064208544|gb|QXI72677|]
View 

HNH endonuclease (plasmid) [Lactiplantibacillus plantarum]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-118 2.55e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.89  E-value: 2.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2064208544  45 SNRWRRT-SRLYREANPICEACLRASKEGdqsrekragminlATSVDHIVPLFAGGSpYDWDNLQSLCDYHHALK 118
Cdd:COG1403     4 GREWPALrRAVLKRDNGRCQYCGRPFSGD-------------ALEVDHIIPRSRGGT-DTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-118 2.55e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.89  E-value: 2.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2064208544  45 SNRWRRT-SRLYREANPICEACLRASKEGdqsrekragminlATSVDHIVPLFAGGSpYDWDNLQSLCDYHHALK 118
Cdd:COG1403     4 GREWPALrRAVLKRDNGRCQYCGRPFSGD-------------ALEVDHIIPRSRGGT-DTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 49-119 1.56e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.07  E-value: 1.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2064208544  49 RRTSRLYREANPICEACLraskegdqsrekrAGMINLATSVDHIVPLFAGGsPYDWDNLQSLCDYHHALKS 119
Cdd:cd00085     1 RSHRLVLLARDGLCPYCG-------------KPGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 88-112 3.10e-03

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 33.85  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*
gi 2064208544  88 SVDHIVPLFAGGSpYDWDNLQSLCD 112
Cdd:pfam14279  14 TIEHIIPESLGGK-NKISNLQTLCK 37
HNHc smart00507
HNH nucleases;
89-115 5.27e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.20  E-value: 5.27e-03
                           10        20
                   ....*....|....*....|....*..
gi 2064208544   89 VDHIVPLFAGGsPYDWDNLQSLCDYHH 115
Cdd:smart00507  26 VDHIIPLSDGG-NDDLDNLVLLCPKCH 51
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-118 2.55e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.89  E-value: 2.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2064208544  45 SNRWRRT-SRLYREANPICEACLRASKEGdqsrekragminlATSVDHIVPLFAGGSpYDWDNLQSLCDYHHALK 118
Cdd:COG1403     4 GREWPALrRAVLKRDNGRCQYCGRPFSGD-------------ALEVDHIIPRSRGGT-DTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 49-119 1.56e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.07  E-value: 1.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2064208544  49 RRTSRLYREANPICEACLraskegdqsrekrAGMINLATSVDHIVPLFAGGsPYDWDNLQSLCDYHHALKS 119
Cdd:cd00085     1 RSHRLVLLARDGLCPYCG-------------KPGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 88-112 3.10e-03

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 33.85  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*
gi 2064208544  88 SVDHIVPLFAGGSpYDWDNLQSLCD 112
Cdd:pfam14279  14 TIEHIIPESLGGK-NKISNLQTLCK 37
HNHc smart00507
HNH nucleases;
89-115 5.27e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.20  E-value: 5.27e-03
                           10        20
                   ....*....|....*....|....*..
gi 2064208544   89 VDHIVPLFAGGsPYDWDNLQSLCDYHH 115
Cdd:smart00507  26 VDHIIPLSDGG-NDDLDNLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH