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Conserved domains on  [gi|1917243210|gb|QOL52020|]
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anti-sigma regulatory factor [Massilia litorea]

Protein Classification

anti-sigma regulatory factor( domain architecture ID 13014755)

anti-sigma regulatory factor similar to RsbT, an ATPase with serine/threonine kinase activity that phosphorylates its antagonist RsbS and stimulates the phosphatase RsbU in a signaling cascade that results in active sigma-B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 8-124 2.51e-29

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


:

Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 102.45  E-value: 2.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917243210   8 DVVGLRKQVRERAVAIGLSLVDQTKLITAASELARNTIKYGGGGAAHLDKLADGLRQGVGLVFVDAGPGIPDLDMALRDG 87
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1917243210  88 YTTGGGLGLGLGGSKRLVDEFEIDTRSGEGTAIAVVK 124
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 8-124 2.51e-29

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 102.45  E-value: 2.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917243210   8 DVVGLRKQVRERAVAIGLSLVDQTKLITAASELARNTIKYGGGGAAHLDKLADGLRQGVGLVFVDAGPGIPDLDMALRDG 87
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1917243210  88 YTTGGGLGLGLGGSKRLVDEFEIDTRSGEGTAIAVVK 124
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
7-125 1.67e-13

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 62.24  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917243210   7 EDVVGLRKQVRERAVAIGLSLVDQTKLITAASELARNTIKYGGGGAA------HLDKLADGLRqgvgLVFVDAGPGIPDL 80
Cdd:COG2172     9 EDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPdgpvevELELDPDGLE----IEVRDEGPGFDPE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1917243210  81 DmaLRDGYTTGGGLGLGLGGSKRLVDEFEIDTRSGeGTAIAVVKW 125
Cdd:COG2172    85 D--LPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 8-124 2.51e-29

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 102.45  E-value: 2.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917243210   8 DVVGLRKQVRERAVAIGLSLVDQTKLITAASELARNTIKYGGGGAAHLDKLADGLRQGVGLVFVDAGPGIPDLDMALRDG 87
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1917243210  88 YTTGGGLGLGLGGSKRLVDEFEIDTRSGEGTAIAVVK 124
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVVARK 117
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
7-125 1.67e-13

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 62.24  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917243210   7 EDVVGLRKQVRERAVAIGLSLVDQTKLITAASELARNTIKYGGGGAA------HLDKLADGLRqgvgLVFVDAGPGIPDL 80
Cdd:COG2172     9 EDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDPdgpvevELELDPDGLE----IEVRDEGPGFDPE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1917243210  81 DmaLRDGYTTGGGLGLGLGGSKRLVDEFEIDTRSGeGTAIAVVKW 125
Cdd:COG2172    85 D--LPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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