|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-390 |
7.67e-127 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 370.34 E-value: 7.67e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSaLGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTK 96
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDFRAVF 176
Cdd:cd17370 80 PLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 177 WVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRdnLRRLGRAYWWVVGIGAVFTLARFSEAFLVLRAQQSGMALALVP 256
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTS--LKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 257 LVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAP 336
Cdd:cd17370 238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1899483498 337 EDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLM 390
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-387 |
1.17e-42 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 153.50 E-value: 1.17e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFMVSaLGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTKPLF 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLavGLMLLWSNDFRAVFWVA 179
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL--GGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 180 VVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFS----EAFLVLRAQQS-GMALAL 254
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAfgalEPFLPLYAAELgGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 255 VPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADT 334
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1899483498 335 APEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-370 |
6.16e-36 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 136.57 E-value: 6.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSD----YLGKRKWLAVLGYGLG 92
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 93 ALTKPLFALAPTTG------VVLTARLLDRVGKGIRGAPRDALVADVTP-AHLRGAAFGLRQSLDTVGAVLGPLLAVGLM 165
Cdd:COG2211 92 ALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 166 LLWSND----FRAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNpirRDNLRRLG--RAYWWVVGIGAVFTLARFSEA 239
Cdd:COG2211 172 AAFGGDaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL---KESLKALLknRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 240 FLVLRAQQS--GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAV--HDHWASVLAGVAL 315
Cdd:COG2211 249 ALLLYYFKYvlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAAL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 316 WGVHMGMTQGLLAAMVADTAPEDL-------RGTAYGFFNLVSGVAMLAASVVAGLLWDRFG 370
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-358 |
6.38e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 126.63 E-value: 6.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 11 RQIPAGVWVLGFVSMLMDISSEMIHSLLPLfMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYG 90
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG-RRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 91 LGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSn 170
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 171 dFRAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRdnlRRLGRAYWWVVGIGAVFTLARFS-EAFLVLRAQQ-S 248
Cdd:COG2814 163 -WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE---LLRRPRLLLLLLLAFLLGFGFFAlFTYLPLYLQEvL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 249 GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLA 328
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318
|
330 340 350
....*....|....*....|....*....|
gi 1899483498 329 AMVADTAPEDLRGTAYGFFNLVSGVAMLAA 358
Cdd:COG2814 319 ALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-359 |
1.49e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.96 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLaVLGYGLGALTKPLF 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-LIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVA 179
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 180 VVPGLLAVVLLCVGLREPKLPPT----HRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFSEAFLVLRAQQSGMALALV 255
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPkpaeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 256 PLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVH---DHWASVLAGVALWGVHMGMTQGLLAAMVA 332
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 1899483498 333 DTAPEDLRGTAYGFFNLVSGVAMLAAS 359
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-387 |
2.06e-25 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 106.14 E-value: 2.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFmVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTKPLF 99
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG-RKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVA 179
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 180 VVPGLLAVvLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRaywwVVGIGAVFTLARFSE----AFLVLRAQQSGMALAlv 255
Cdd:cd17489 157 AVLALLAL-LLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK----VLPPALILFLASIAYgaisTFLPLYAAERGISNA-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 256 PLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTA 335
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 336 PEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-387 |
2.69e-24 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 103.08 E-value: 2.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTK 96
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG-RKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAvglMLLWSNDFRAVF 176
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG---GLLLLYSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 177 WVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRL-GRAYWWVVGIGAVFTLARFS-EAFLVLRAQQSGMALAL 254
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLrDRAFLLFLLASFLISLIYFQlESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 255 VPLVMVAMN-LVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVAD 333
Cdd:cd17329 237 LLGLLLALNaLLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1899483498 334 TAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-391 |
5.25e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 102.26 E-value: 5.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLfMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTK 96
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFG-RKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAvGLMLLWSndFRAVF 176
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAIS--WRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 177 WVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFSEAF-----LVLRAQQSGMA 251
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTylpflLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 252 LALVplvMVAMNLVYALSAYPFGKLSD-RMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAM 330
Cdd:cd17474 236 IGLL---FAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899483498 331 VADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMA 391
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-389 |
1.04e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.87 E-value: 1.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFMVSaLGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLaVLGYGLGALTKPLF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVL-LLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDFRAVFWVA 179
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 180 VVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAY----WWVVGIGAVFTLARFS--EAFLVLRAQQSGMALA 253
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLknpgLWLLLLAIFLVNLAYYsfSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 254 LVPLVMVAMN-LVYALSAYPFGKLSDR-MGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMV 331
Cdd:cd06174 239 AVAGLLLSLFgLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1899483498 332 ADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDR-FGASFTFYAGALFCAVTLACL 389
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-402 |
3.83e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.10 E-value: 3.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLG--YGLGAL 94
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLllLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 95 tkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRA 174
Cdd:COG2223 86 ---LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG--WRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 175 VFWVAVVPGLLAVVLLCVGLRE-PKLPPTHRRTNPIRRDNLRRLGRAYW-WVVGIGAVFTLARFSEAFLVLRAQQSGMAL 252
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDpPAGAAAAAKASLRDQLEALRDPRFWLlSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 ALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLA-VHDHWASVLAGVALWGVHMGMTQGLLAAMV 331
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 332 ADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGA-SFTFYAGALFCAVTLACLMASARARPGGEAA 402
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
43-390 |
1.45e-19 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 89.20 E-value: 1.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 43 VSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTKPLFALAPTTGVVLTARLLDrvgkGIR 122
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLS----GIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 123 GA---PRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCvGLREPKl 199
Cdd:cd17490 99 AAtwvSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFG--MRAPFLLAALAGVLGFILSL-FIKEER- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 200 pPTHRRTNPIRRDNLRRLGRAYWWVVGI-GAVFTLARFSEA--FLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFG-K 275
Cdd:cd17490 175 -REKKPVLTELKELLSVLKDKKLLFFSLlAILQQMITFSTTfgFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 276 LSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAM 355
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGM 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 1899483498 356 LAASVVAGLLWDRFGASFTFY-AGAL-FCAVTLACLM 390
Cdd:cd17490 334 FLGPVLVGIISEAFGLQTGFFvIGVIaLLAAILSLAY 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
17-388 |
2.37e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 2.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLfMVSALGASALVVGIvegMAEATALMVKV---FSGVLSDYLGKRKwLAVLGYGLGA 93
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGL---LVSAYALGYALgalLLGPLSDRIERRR-LLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 94 LTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFR 173
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG--WR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 174 AVFWVAVVPGLLAVVLLCVGLrePKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFSEAFLVLR---AQQSGM 250
Cdd:cd17324 154 AAFLAIAVLALLAALLLWRLL--PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLApflTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 251 ALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAM 330
Cdd:cd17324 232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1899483498 331 VADTAPEDlRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLAC 388
Cdd:cd17324 312 VLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-397 |
3.00e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 88.39 E-value: 3.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLA--VLGYGLGAL 94
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAigLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 95 tkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWsnDFRA 174
Cdd:COG2271 91 ---LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF--GWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 175 VFWVAVVPGLLAVVLlcvglrepklppthrrtnpirrdnlrrlgrAYWWVVGIGAVFTLARFS-EAFLVLRAQQS-GMAL 252
Cdd:COG2271 166 AFLILGLPGLLLALL------------------------------RFWLLALAYFLVYFALYGfLTWLPTYLVEVrGLSL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 ALVPLVMVAMNLVYALSAYPFGKLSDRMGHAR--LLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAM 330
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899483498 331 VADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARP 397
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-393 |
4.44e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 4.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 18 WVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWL--AVLGYGLGALT 95
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLiaGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 kPLFAlaPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLwsnDFRAV 175
Cdd:cd17473 82 -GLFL--DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI---GWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 176 FWVAVVpGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTL--ARFSEAFLVLRAQQSGMAlA 253
Cdd:cd17473 156 FLVYLL-ALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLfyVIPIQLPFLLQERGGGSA-A 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 254 LVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVAD 333
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899483498 334 TAPEDLRGTAYGFFNLVSGVAMLAASVVAGLL-WDRFGASFTFYAGALFCAVTLACLMASA 393
Cdd:cd17473 314 LVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
38-387 |
1.40e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 77.66 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVsALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTKPLFALAPTTG----VVLTARL 113
Cdd:cd06173 22 LPWLVL-QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 114 LDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVpGLLAVVLLCVG 193
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG--PGGAFAINAL-SFLLSALLLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 194 LREPKLPPTHRRTNPIRRDNLRRLGRAYW--------------WVVGIGAVFTLARFSEAFLVLRAQQSGMALALVPLVM 259
Cdd:cd06173 178 IRRPPPAAPGESSSLLLRDLREGLRYLRRspllrllllalalfALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 260 VAMNLVYalsaypfGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDL 339
Cdd:cd06173 258 LLGALLL-------GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1899483498 340 RGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-390 |
3.71e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 76.10 E-value: 3.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVSALGASALVVGIVEGmaeatalmvkVFSGVLSDYLGKRKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLD 115
Cdd:cd17316 33 LSLLQTGLLFAAGFLGRPIGA----------LLFGYLGDRIGRKKALilTLLLFGLATL---LIGLLPTPILLLVLRFLQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 116 RVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDF--RAVFWVAVVPGLLAVVLlcvg 193
Cdd:cd17316 100 GIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwRILFLIGALPALLALLL---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 194 lrepklppthrrtnpiRRDNLRRLGRAYWWVVGIGAVFTLarfseaFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPF 273
Cdd:cd17316 176 ----------------RRRTLLLILLWFFISFGYYGLTTF------LPTYLQTVLGLSPATSSLYLLLISLGALVGALIA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 274 GKLSDRMGHARLLGWG--LAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGF-FNLV 350
Cdd:cd17316 234 GLLSDRIGRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLG 313
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1899483498 351 SGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLM 390
Cdd:cd17316 314 RLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-387 |
1.28e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 74.52 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 22 FVSMLMDISSEMIHSLLPLFMvSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTkPLFAL 101
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSV-LLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 102 APTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLavgLMLLWSNDFRAvFWVAVV 181
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---LALVGTAGALP-FLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 182 PGLLAVVLLCVGLREPKLPPTHRRTNPIRrdnLRRLGRAYWWVVGIGAVFTLARFSeaFLVLRAQQSGMALALVPLVMVA 261
Cdd:cd17477 157 LLLLALVPLLLTRRAAPEIEEAESISLRR---LLRIAPLALLGAFVAGFLEGAFYS--LLPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 262 MNLVYALSAYPFGKLSDRMGHARLLGW-GLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLR 340
Cdd:cd17477 232 FVLGGLLLQWPLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDEL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1899483498 341 GTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
69-365 |
1.76e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 74.13 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 69 VFSGVLSDYLGKRKwLAVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQS 148
Cdd:cd17321 49 LLAGRLGDRFGRKR-VFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 149 LDTVGAVLGPLLavGLMLLWSNDFRAVFWVAVVPGLLAVVLlcvglrepklppthrrtnpirrdnlrrlGRAYWWVVGIG 228
Cdd:cd17321 128 VVGIGAALGPLL--GGLLLELFGWRWIFLINVPIGLVALLL----------------------------ARTFSGAVLAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 229 AVFTLARFSEAFLVLRAQQS--GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLA---VH 303
Cdd:cd17321 178 FLLGAALGGLLFLLPLYLQGvlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgAD 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 304 DHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLL 365
Cdd:cd17321 258 SSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-190 |
2.10e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.15 E-value: 2.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTK 96
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLavGLMLLWSNDFRAVF 176
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL--GGFLYDAFGFATPF 357
|
170
....*....|....
gi 1899483498 177 WVAVVPGLLAVVLL 190
Cdd:cd17325 358 LAAAALLLLAAVLF 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
20-390 |
7.57e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 72.20 E-value: 7.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPlFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRkWLAVLGYGLGALTKPLF 99
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLP-LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR-YLLPLGPLLTGLGLSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPaHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVA 179
Cdd:cd17478 79 GFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFG--GLGLLILL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 180 VVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFS-EAFLVLRAQQSGMALALVPLV 258
Cdd:cd17478 156 IIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSlTTFLPFYLVQRGYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 259 MVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALwGVHMGMTQGLLAAMVADTAPED 338
Cdd:cd17478 236 LSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLA-GFLLFASFPVTVVLAQELLPGN 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 339 lRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLM 390
Cdd:cd17478 315 -VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
18-389 |
7.68e-13 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 69.58 E-value: 7.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 18 WVLGFVSMLMDISSEMIHSLLPLFmVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYL----GKRK----------- 82
Cdd:cd17313 2 FLLGFGFFGIEFGWALENSYVPPI-LQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCnsriGRRRpfilvgaplaa 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 83 -------WLAVLGYGLGALTKPLFALAPTTGVVLtarlLDRVGKGIRGaPRDALVADVTPAHLRGAAFGLRQSLDTVGAV 155
Cdd:cd17313 81 lglilipNAADIGLALGDGPRTWALVLFVLGIVL----LDFAMNVCQG-PVRALLPDLVPPEQRSKANGIINFMGGLGGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 156 LGplLAVGLMLLWSNDF--------RAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDN---------LRRLG 218
Cdd:cd17313 156 LG--YLLGAILWDHNWFgfalggnlKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGevlksllklLKIMP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 219 RAYW--------WVVGIGAV---FTLARFSEAFLVLRAQQS--GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARL 285
Cdd:cd17313 234 RSLLrlllviffWWIAFFPFelfFTDYMGEEVYHGTSAASShyGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 286 LGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLR--GTAYGFFNLVSGVAMLAASVVAG 363
Cdd:cd17313 314 YLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAG 393
|
410 420
....*....|....*....|....*.
gi 1899483498 364 LLWDRFGASFTFYAGALFCAVTLACL 389
Cdd:cd17313 394 PIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
240-403 |
1.68e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.08 E-value: 1.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 240 FLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVH 319
Cdd:COG2814 32 ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 320 MGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARPGG 399
Cdd:COG2814 112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPA 191
|
....
gi 1899483498 400 EAAR 403
Cdd:COG2814 192 ARAR 195
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
72-403 |
7.68e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 66.33 E-value: 7.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 72 GVLSDYLGKRKWLAVLGYGLGALTKPLFALAPTTGVVLTARL--LDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSL 149
Cdd:COG2270 73 GAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLfvLANIGFEGSLVFYNAFLPDIATPEEIGRVSGLGWAL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 150 DTVGAVLgpLLAVGLMLLWSNDF----------RAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIR------RDN 213
Cdd:COG2270 153 GYLGGVL--LLLINLALFLKPEAfglpdageavRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRagfrelRRT 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 214 LRRLGR---------AYWWV-VGIGAVFTLArfseafLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHA 283
Cdd:COG2270 231 LRELRRyrdllrfllAYFFYrDGVQTVIAFA------GIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPK 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 284 RLLGWGLAVLIAADL-VLAVHDHWASVLAGvALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVA 362
Cdd:COG2270 305 RVILVSLVIWIVVCLaAYFLTTALAFWILG-LLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLF 383
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1899483498 363 GLLWDRFGASFTFYAGALFCAVTLACLMASARARPGGEAAR 403
Cdd:COG2270 384 GLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPRGRAAAG 424
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
22-381 |
1.10e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.75 E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 22 FVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMA-EATALMVKVFS---GVLSDYLGKRKWLAVLGYGlGALTKP 97
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAfSSTFLVSAIFSpiwGRLADRYGRKPMLLRASLG-MAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 98 LFALAPTTGVVLTARLLDRVGKGIRGAPrDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLavGLMLLWSNDFRAVFW 177
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVFSGYVPNA-TALIASQTPKEKSGWALGTLSTGVVAGTLIGPLL--GGFLADLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 178 VAVVPGLLAVVLLCVGLREPKLPPT-HRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFS-EAFLVLRAQQ---SGMAL 252
Cdd:cd17391 159 ITGGLLFLAFLLTLFFVKEDFKPVEkKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSiEPILTLYIRQlmgDASNL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 ALVP-LVMVAMNLVYALSAYPFGKLSDRMGHARLLgwgLAVLIAADLVL----AVHDHWaSVLAGVALWGVHMGMTQGLL 327
Cdd:cd17391 239 AFISgLVFSATGVSSLLSAPRLGKLGDRIGHHRIL---LGALLASALLYipqaFVQTPW-QLGILRFLLGLATGGLLPAI 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1899483498 328 AAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALF 381
Cdd:cd17391 315 NSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-396 |
4.37e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.12 E-value: 4.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 42 MVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRK--WLAVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGK 119
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERtlLLALLLLAAGLL---LRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 120 GIRGAPRDALVADVTPAHlRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCVGLREPKL 199
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALG--WRGALAVWALLALLALLLWLPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 200 PPTHRRTNPIRRDNLRRlgRAYWWVVGIGAVFTLARFSE-AFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSD 278
Cdd:COG2807 198 AAAAAPAAASLRSLWRS--PLAWLLTLFFGLQSLLYYAVvAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 279 RMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLR-GTAYGFFNLVSGVAMLA 357
Cdd:COG2807 276 RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAAL 355
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1899483498 358 ASVVAGLLWDRFGA-SFTFYAGALFCAVTLACLMASARAR 396
Cdd:COG2807 356 GPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
245-389 |
8.73e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 62.82 E-value: 8.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 245 AQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQ 324
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALF 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899483498 325 GLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACL 389
Cdd:pfam07690 104 PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-390 |
9.97e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 62.95 E-value: 9.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTKPLF 99
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLdRVGKGIRGAPR----DALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAV 175
Cdd:cd17471 81 AFLRNYWVLLLVGVV-LLSLGAAAFPQlfalAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG--FTGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 176 FWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGraywwVVGIGAVFTLARFSEA--------FLV----L 243
Cdd:cd17471 158 FLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRR-----LLLLFAAFTLLFAANSmyiiamplYVTnelgG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 244 RAQQSGMALALVPLVMVAMNLVyalsaypFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMT 323
Cdd:cd17471 233 SESWVGLLFGLAAALEIPIMLL-------AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGIT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899483498 324 QGLLAAMVADTAPeDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLM 390
Cdd:cd17471 306 AGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-386 |
1.48e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.21 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 29 ISSEMIHSLLPLFMVSA--LGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTKPLFALAPTTG 106
Cdd:cd17330 10 LGFGIVFPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYG-RKPVLLLSLAGSAVSYVLLGLSRNLW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 107 VVLTARLLDRVGKGIRGAPRdALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLavGLMLLWSNDFRAVFWVAVVPGLLA 186
Cdd:cd17330 89 LLFLARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGIISAAFGLGFILGPAL--GGFLSTPYGYALPFLVAAALALLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 187 VVLLCVGLRepklppthrrtnpirrdNLRRLGRAYW--WVVGIGAVFTLARFSEAFLVLRAQQSGMALALVPLVMVAMNL 264
Cdd:cd17330 166 LVLVLFFLP-----------------PLRRLLLVYFliALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 265 VYalsaypFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAY 344
Cdd:cd17330 229 LL------IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1899483498 345 GFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTL 386
Cdd:cd17330 303 GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
41-368 |
4.17e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 60.71 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 41 FMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKwlaVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKG 120
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERR---VLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 121 IRGAPRDALVADVT--PAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCVGLREPK 198
Cdd:cd17475 98 YGSVQPGGGRAIMRwfPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG--WRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 199 LPPTHRRTNPIRRDNLRRLGR--AYWWVVGIGAVFTLARFS-EAFLVLRAQ-QSGMALALVPLVMVAMNLVYALSAYPFG 274
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRnrDVWLIAIAGALLVAPQFAlLTFLLLFLHdHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 275 KLSDRMGHAR------LLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFN 348
Cdd:cd17475 256 RVSDRVFGGRrrpvlvITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLAN 335
|
330 340
....*....|....*....|
gi 1899483498 349 LVSGVAMLAASVVAGLLWDR 368
Cdd:cd17475 336 TINFIGIAIGPPLFGLLVDA 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-198 |
4.29e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 4.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 13 IPAGVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKR-KWLAVLGYGL 91
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 92 GALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVglMLLWSND 171
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVG--YLLDATG 335
|
170 180
....*....|....*....|....*..
gi 1899483498 172 FRAVFWVAVVPGLLAVVLLCVGLREPK 198
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
36-389 |
1.17e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 59.52 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 36 SLLPLFMV--SALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTkpLFALAPTTGVVLTArL 113
Cdd:cd17335 15 SLLPFLSVylKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLF--FLSLFFVAQIFWLL-L 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 114 LDRVGKGIRGAPRDALVADVTPAHLR--GAAFGLRQSLDTVGAVLGPLLaVGLMLLWSN---DFRAVFWVAVVPGLLAVV 188
Cdd:cd17335 92 LLVILGAFFSAPVVPLVDSITLQYLGeeRERYGKQRLWGSIGFGIAALL-VGILIDRSStykNYTIAFYVFAVLMLLALL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 189 LLcvglREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVgIGAVFTL---ARFSEAFLVLRAQQSGMALALVPLVMVAMNLV 265
Cdd:cd17335 171 LA----LKFPFRPKHPEPNENTGGLLALLRNPRVLAF-LLVAFLMgfgHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 266 YALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYG 345
Cdd:cd17335 246 EIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1899483498 346 FFN-LVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACL 389
Cdd:cd17335 326 LLQgLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAF 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-397 |
4.81e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.70 E-value: 4.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 22 FVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWL--AVLGYGLGALtkpLF 99
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLviTILLFAVFTL---LC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 100 ALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDF--RAVFW 177
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIawRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 178 VAVVPGLLaVVLLCVGLREPKLPPTHRRTNPI--RRDNLRRLGRA-------YWWVVGIGAVFTLARFSEAFLVLRAQQS 248
Cdd:cd17371 162 LGALPALL-VLFIRRFVKEPPQWQAARAARRHfaDRPSLRELFSPpllrttlLASLLATGALGGYYGITTWLPSYLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 249 GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHAR--LLGWGLAVLIAADLVLAVHDHWASVLAGVALwGVHMGMTQGL 326
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNnfALFALGSAISILLYFFLPLSPTLILILGFPL-GFFASGPFSG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899483498 327 LAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFtfyAGALFCAVTLACLMASARARP 397
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGT---AIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
17-390 |
7.33e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.20 E-value: 7.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLfMVSALGASALVVGIVEGM-AEATALMVkVFSGVLSDYLGKRKwLAVLGYGLGALT 95
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPA-IARDLGASASAVQLTLSAyLLGFALGQ-LLYGPLSDRFGRRP-VLLAGLLLFILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 KPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAV 175
Cdd:cd17320 78 SLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFG--WRAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 176 FWVAVVPGLLAVVLlcVGLREPKLPPTHRRTNPIRR--DNLRRLGR-----AYWWVVGIGAVFTLARFSEAFLVLRAQQs 248
Cdd:cd17320 156 FVFLALLGLLLLLL--VLLFLPETLPEEKRKPLLSSllRAYKRVLKnrrflGYALALGLSFAGLFAYLAAAPFIYIEQL- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 249 GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAV-----HDHWASVLAGVALWGVHMGMT 323
Cdd:cd17320 233 GLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLaallgGLSLWPLVAPLFLIFFGFGLI 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899483498 324 QGLLAAMVADTAPEDlRGTAYGFFNLVSGVAMLAASVVAGLLWDrfGASFTFYAGALFCAVTLACLM 390
Cdd:cd17320 313 FPNATSLALEPFPHV-AGTASALLGFLQFLIGALAGALVGLLPN--GTALPMGLLILVLGLLALLLL 376
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-396 |
7.83e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 7.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 41 FMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKG 120
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG-YKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 121 IRGAPRDALVADVTPAHlRGAAFGLRQSLDTVGAVLGPLLAVGLMLL-WSNDFRAVFWV-AVVPGLLAVVLLCVGLrePK 198
Cdd:COG0738 112 LLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLgLSLSWHLPYLIlAVLLLLLALLFLRSKL--PE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 199 LPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVF------TLARFSEAFLVlraQQSGMALALVPLVMVAMNLVYALSAYP 272
Cdd:COG0738 189 IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyvgaegAIGDWLPLYLK---DVLGLSEATAALGLSLFWGGMTIGRFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 273 FGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDlRGTAYGFFNLVSG 352
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGI 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1899483498 353 VAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARAR 396
Cdd:COG0738 345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
239-390 |
9.78e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.45 E-value: 9.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 239 AFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGV 318
Cdd:cd17489 17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 319 HMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLM 390
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF 168
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
64-396 |
1.91e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 55.72 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 64 ALMVKVFS---GVLSDYLGKRKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLDRVgKGIRGAPRDALVADVTPAHL 138
Cdd:cd17388 48 ALMQFIFApilGALSDRFGRRPVLllSLAGAALDYL---LMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQ 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 139 RGAAFGLRQSLDTVGAVLGPLLAvglMLLWSNDFRAVFWVAVVPGLLAVVLLCVGLREPkLPPTHRRTNPIRRDN---LR 215
Cdd:cd17388 124 RARNFGLLGAAFGLGFIAGPALG---GLLGEISPRAPFLVAAGLNGLNFLLGLFVLPES-LPPERRRAFRWRRANpfgSL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 216 RLGRAYWWVVGIGAVFTLAR------------FSEAFLVLRAQQSGMALALVPLVMVamnLVYALSAypfGKLSDRMGHA 283
Cdd:cd17388 200 RWLTGFPGLLGLLAVFFLIQligqvpattwvlFTEDRFDWSPTMVGLSLAVFGLLHA---LFQAFVT---GPIAKRLGEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 284 RLLGWGLAVLIAADLVLAVHDH-WA--SVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASV 360
Cdd:cd17388 274 RAILLGLAADALGFLLLAFATQgWMvfPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353
|
330 340 350
....*....|....*....|....*....|....*....
gi 1899483498 361 VagllwdrFGASFTFYAGALF---CAVTLACLMASARAR 396
Cdd:cd17388 354 I-------FAASPATWPGLAWiigAALYLICLVLAYRFF 385
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-190 |
2.65e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYL--GKRKWLAVLGYGLGAL 94
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 95 TKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLaVGLMLLWSNDFRA 174
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL-IGYLVDATGSYTA 339
|
170
....*....|....*.
gi 1899483498 175 VFWVAVVPGLLAVVLL 190
Cdd:cd17319 340 AFLFLAAVALLAALLV 355
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
69-390 |
4.45e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.50 E-value: 4.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 69 VFSGVLSDYLGKRKWLAVLGYGLGALTKpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQS 148
Cdd:cd17319 56 VPGGWLLDRFGARKVLAVSMLLWSLFTA-LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 149 LDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLcvglrepklppthrrtnpirrdnlRRLGRAYWWVVGI- 227
Cdd:cd17319 135 GAPLGAAIGPPLSGWLLLLFG--WRWAFIIEGLLGLLLAVLW------------------------WFYLRQVWGLALGy 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 228 -GAVFTLARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHAR---LLGWGLAVLIAADLVLAVH 303
Cdd:cd17319 189 fGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 304 DHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFG---ASFTFYAGAL 380
Cdd:cd17319 269 TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsytAAFLFLAAVA 348
|
330
....*....|
gi 1899483498 381 FCAVTLACLM 390
Cdd:cd17319 349 LLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
215-384 |
4.63e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 4.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 215 RRLGRAYWWVVGIGAVFTLA----RFSEAFLVLRAQQS-GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWG 289
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLnyldRSNLSVAAPPLQADlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 290 LAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRF 369
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170
....*....|....*
gi 1899483498 370 GASFTFYAGALFCAV 384
Cdd:COG2271 162 GWRAAFLILGLPGLL 176
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
148-391 |
8.68e-08 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 53.68 E-value: 8.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 148 SLDTVGAVLGPLLAVGLM-----LLWSNDFRAvfWVAVVPGLLAVVLLCVGL------REP----KLPPTHRRTNPIRRD 212
Cdd:cd17369 144 SFPQLGAPVGLLLATGVFlllsaLLSDEAFLS--WGWRIPFLLSAVLVAVGLyirlrlEETpvfrRAKEAGQVVRAPLVE 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 213 NLRRLGRAYWWVVGIGAVFTLARF-SEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYP-FGKLSDRMGHARLLGWG- 289
Cdd:cd17369 222 VLRRHWRALLLAIGLRLAENVLFYlFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPlFGWLSDRVGRRPVYLAGa 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 290 -LAVLIAADLVLAV--HDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGF-FNLVSGVAMLAASVVAGLL 365
Cdd:cd17369 302 lLAALFAFPFFWLLdtGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLgYQLGAILGGGFAPLIATAL 381
|
250 260
....*....|....*....|....*.
gi 1899483498 366 WDRFGAsfTFYAGALFCAVTLACLMA 391
Cdd:cd17369 382 VAATGS--WWPVALYLAALAVISLVA 405
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-190 |
1.23e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.20 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 16 GVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALT 95
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 KPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAvGLMLLWSNDFRAV 175
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA-GFLLAATFGLTGA 362
|
170
....*....|....*
gi 1899483498 176 FWVAVVPGLLAVVLL 190
Cdd:cd06174 363 FLVLAVLLLLAAILL 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
239-397 |
1.81e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 239 AFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGV 318
Cdd:cd06174 17 PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899483498 319 HMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFtFYAGALFCAVTLACLMASARARP 397
Cdd:cd06174 97 GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW-RAVFLIAAALALLAAILLLLVVP 174
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
16-189 |
2.44e-07 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 52.37 E-value: 2.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 16 GVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKrKWLAVLGYGLGALT 95
Cdd:PRK11646 11 GKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGA-KPMIVTGMLMRAAG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 KPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLwsnDFRAV 175
Cdd:PRK11646 90 FATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQY---DFRLV 166
|
170
....*....|....
gi 1899483498 176 FWVAVVPGLLAVVL 189
Cdd:PRK11646 167 CATGAVLFVLAAAF 180
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-192 |
2.45e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.20 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVF-SGVLSDYLGKRKwLAVLGYGLGALT 95
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERK-LLRLGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 KPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLlaVGLMLLWSNDFRAV 175
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPL--LAGPLYSFLGPGVP 332
|
170
....*....|....*..
gi 1899483498 176 FWVAVVPGLLAVVLLCV 192
Cdd:cd17330 333 FLLAAGLLLIALFLLSL 349
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
257-404 |
2.98e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 2.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 257 LVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAP 336
Cdd:COG2223 44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1899483498 337 EDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARPGGEAARA 404
Cdd:COG2223 124 PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA 191
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
46-387 |
3.35e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 51.81 E-value: 3.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 46 LGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAV--LGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRG 123
Cdd:cd17315 29 FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIaaVLYVIGAL---LSALAPNVWVLIVGRFLLGLGVGLAS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 124 APRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDFRAVFWVAVVPGLLAVVLLCVglrepkLPPTH 203
Cdd:cd17315 106 VLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFF------LPESR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 204 RRTNPIRRDNLRRLgraywwvVGIGAVFTLAR--FSEAFLVlraQQSGMALALVPLVMVAMNLVYAlsaypfgKLSDRMG 281
Cdd:cd17315 180 ALLVGVGLQLLQQL-------TGINAVMYYAPtiFKSAGGG---TASILASIIVGVVNLLATLVAI-------RLVDKVG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 282 HARLLGWGLAVLIAADLVLAVHDHW---ASVLAGVALWGVHM-----GMTQG-LLAAMVADTAPEDLRGTAYGFFNLVSG 352
Cdd:cd17315 243 RRPLLLIGFAGMAASLLLLAIAFLLpalAKAAGWLALLGILLyiaafAMGAGpVPWLLLSEIFPLRIRGKGMAIATLVNW 322
|
330 340 350
....*....|....*....|....*....|....*
gi 1899483498 353 VAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17315 323 IFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALV 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
249-404 |
3.53e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 249 GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLA 328
Cdd:COG0477 45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1899483498 329 AMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARPGGEAARA 404
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLA 200
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
69-393 |
5.39e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.05 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 69 VFSGVLSDYLGKRKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLR 146
Cdd:cd17365 52 LLAGPLADRFGRKRVLlvSVALFGLFTL---LTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 147 QSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCVGLrepklppthrrtnpirrdnlrrlgrAYWwvVG 226
Cdd:cd17365 129 FCGYPLGAALGGFLAAALIPAFG--WRSVFLLGGVPPLILLPLLRGTL-------------------------LLW--VT 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 227 IGAVFTLARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAV-LIAADLVLAVHDH 305
Cdd:cd17365 180 FFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALgAVSLALLGVSPAS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 306 WASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLL----WDRFGASFTFYAGALF 381
Cdd:cd17365 260 LVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLlaagLGPESVFLALAIPAAL 339
|
330
....*....|..
gi 1899483498 382 CAVTLACLMASA 393
Cdd:cd17365 340 GALAVLLLRLRR 351
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-302 |
1.26e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 1 MSAPARLPVLRQIPAgVWVLGFVSMLMDISSEMIHSLLPLfMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGK 80
Cdd:COG0477 1 MSSTDAAPTRRRRRA-LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 81 RKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGP 158
Cdd:COG0477 79 KRVLliGLLLFGLASL---LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 159 LlaVGLMLLWSNDFRAVFWVAVVPGLLAVVLLcvglrePKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIGAVFTLARFSE 238
Cdd:COG0477 156 L--LGGLLVAALGWRWIFLINAPLGLLALVLR------LRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1899483498 239 AFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAV 302
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
245-401 |
1.74e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 245 AQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQ 324
Cdd:cd17324 26 ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899483498 325 GLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARPGGEA 401
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
40-384 |
3.02e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 48.72 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 40 LFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRK---WLAVLgYGLGALtkpLFALAPTTGVVLTARLLDR 116
Cdd:cd17359 25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKtllISAVL-FFISAL---GSAFSPNFTIFIIARIIGG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 117 VGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSNDF------RAVFWVAVVPgllAVVLL 190
Cdd:cd17359 101 LAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWlgaegwRWMLGLEAIP---AILFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 191 CVGLREPKLPPThrrtnpirrdnLRRLGRAYWWV----------VGIGAV-------FTLARFSEAFLVLraQQSGMALA 253
Cdd:cd17359 178 LGMLFIPESPRW-----------LVSKGKPILIIgiglaifqqfVGINVIfyygpeiFQNAGFSENAALL--QTIGIGVV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 254 LVPLVMVAMNLVyalsaypfgklsDRMGHARLLGWGLAVLIAADLVLAV------HDHWAS--VLAGVALWGVHMGMTQG 325
Cdd:cd17359 245 NVIFTIIAILLV------------DKVGRKPLLLIGSIGMAISLLLIGTafyfapGSQASGivALVLILLFVAFFAMSWG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 326 LLA-AMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAV 384
Cdd:cd17359 313 PVTwVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVL 372
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
68-375 |
6.13e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.76 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 68 KVFSGVLSDYLGKRkWLAVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQ 147
Cdd:TIGR00881 47 KFVMGSVSDRSNPR-VFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 148 SLDTV-GAVLGPLLAVGLMLLWSNDfravfWVAVVPGLLAVV---LLCVGLREP----KLPPTHRRTNPIRRDNLRR--- 216
Cdd:TIGR00881 126 CSHNVgGGLLPPLVLFGIAELYSWH-----WVFIVPGIIAIIvslICFLLLRDSpqscGLPPAEEMPNEEPDGDAEKkee 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 217 ------------LGRAYWWVVGIGAVFT--LARFSEAFLVLRAQQSgmaLALVPLVMVAMNLVYALSAYP----FGKLSD 278
Cdd:TIGR00881 201 eltkkqiflqyvLLNKVLWYISLGYVFVyvVRTGILDWSPLYLTQE---KGFSKEKASWAFTLYELGGLVgtllAGWLSD 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 279 RMGHARllGWGLAVLIAADLVLAVHDHWASVlAGVALWGVHMGMTQG--------LLAAMVADTAPEDLRGTAYGFFNLV 350
Cdd:TIGR00881 278 KLFNGR--RGPLAVFFMALIIVSLLVYWLNP-AANPLMDLICLFALGflvygpqmLIGVIASELAPKKAAGTAAGFVGFF 354
|
330 340
....*....|....*....|....*
gi 1899483498 351 SGVAMLAASVVAGLLWDRFGASFTF 375
Cdd:TIGR00881 355 AYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
21-370 |
6.60e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 48.07 E-value: 6.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 21 GFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYL----GKRKWLAVLGYGLGALTK 96
Cdd:pfam13347 3 GSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTrtrwGRRRPWLLLSAIILAVSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTA------RLLDRVGKGIRGAPRDALVADVTP-AHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWS 169
Cdd:pfam13347 83 ILLFTPPELGRAPLFiwllatYILLRIAYTFFEIPYWSLGPELTRdYDERTSLTSYRSFFSVGGGLLAAALAFPLVLILG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 170 ND------FRAVFWVAVVPGLLAVVLLCVGLREP---KLPPTHRRTNPIR-RDNLRRLGR--AYWWVVGIGAVFTLARFS 237
Cdd:pfam13347 163 GTglerkgYRIFALIGAVLMLLGVIITAAGTKERvsmRSKEDTGQKEAGSlLDMLKEVFRnrAFLILLASFLLAALAMGV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 238 EAFLVLR-----AQQSGMALALVPLVMVAMNLVYALSAYpfgkLSDRMGHARLLGWGLAVLIA--ADLVLAVHDHWASVL 310
Cdd:pfam13347 243 LNGLLLYyfryvLGNGFAASAFPLVFTIGALLGIPLWPP----LAKRIGKKNTYILGALITIAgfALALLLGPNNTLLFL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1899483498 311 AGVALWGVHMGMTQGLLAAMVADTA-------PEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFG 370
Cdd:pfam13347 319 VLYIIIGFGYGSSFFLPWSMLADVVdygelrtGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFG 385
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
14-179 |
8.13e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 8.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 14 PAGVWVLGFVSMLMDISSEMIHSLLPLFmVSALGAS----ALVVGIVEGMAEATALMVKVFSGVLSD-YLGKRKWLAVLG 88
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLY-IRQLMGDasnlAFISGLVFSATGVSSLLSAPRLGKLGDrIGHHRILLGALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 89 YGLGALTKPLFALAPTTGVVLtaRLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLW 168
Cdd:cd17391 279 ASALLYIPQAFVQTPWQLGIL--RFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHF 356
|
170
....*....|.
gi 1899483498 169 SndFRAVFWVA 179
Cdd:cd17391 357 G--YRAVFVVT 365
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
17-196 |
1.04e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFM--------VSALGASALVVGIVEGmaeatalmvKVFSGVLSDYLGkRKWLAVLG 88
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAedfhvseeVANLGVSLFVLGFGLG---------PLIWAPLSELYG-RRPVYLVS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 89 YGLGALTKPLFALAPTTGVVLTARLLdrvgKGIRGAPRDAL----VADVTPAHLRGAAFGLRqsldTVGAVLGPLLA--V 162
Cdd:cd17323 71 LFIFVIFQIGCALAPNIAMLIILRFL----QGFFGSSPLAIgagtIADLFTPEERGKAMGVY----SLGPLLGPALGpiI 142
|
170 180 190
....*....|....*....|....*....|....
gi 1899483498 163 GLMLLWSNDFRAVFWVAVVPGLLAVVLLCVGLRE 196
Cdd:cd17323 143 GGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-381 |
1.15e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 19 VLGFVSMLMDISseMIHSLLPLFMvSALGASALVVG-IVEGMAEATALMVKVfSGVLSDYLGkRKWLAVLGYGLGALTKP 97
Cdd:cd17503 2 LLGAFMAILDTT--IVNVALPTIM-GDLGASLDTVQwVITSYLLALAIMIPL-SGWLADRFG-TRRLFLTALALFTLGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 98 LFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAvGLMLLWSNdFRAVFW 177
Cdd:cd17503 77 LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLG-GWLTDNLS-WRWIFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 178 VAVVPGLLAVVLLcvglrePKLPPThrrtnpIRRDNLRRLGRAYWWVVGI---GAVFTLARFSEAFLVLRAQQSGMALAL 254
Cdd:cd17503 155 INLPIGILALLLA------PLLDLR------LFKDRNFTLGLLLSFLLGLglfGAMFLLPLYLQNVLGYSAFESGLVLAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 255 VPLVMVAMNLVYalsaypfGKLSDRMGHARLLGWGLAVLIAADLVLAV--HDHWASVLAGVALW-GVHMGMTQGLLAAMV 331
Cdd:cd17503 223 GGLASAILSPLV-------GRLLDKFGPRLLLLAGLLLLALGTLLLAFltPDTSLWLIILPLFIrGLGMGLVFMPLNTLA 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1899483498 332 ADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALF 381
Cdd:cd17503 296 LNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELL 345
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-384 |
1.25e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 64 ALMVKVFSGVLSDYLGKRKWLaVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPaHLRGAAF 143
Cdd:cd17333 44 YLIGSLLAGFLMKRLGRRRTL-ILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 144 GLRQSLDTVGAVLGPLLAvGLMLLWSNDFRAVFWVA--VVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAY 221
Cdd:cd17333 122 NVLHGFFGLGALIGPLIA-TSLLTSELSWSWAYLIIglIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 222 WWVVGIGAVFTL---ARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADL 298
Cdd:cd17333 201 IILGALALFLYVgaeTAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 299 VLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEdLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAG 378
Cdd:cd17333 281 ILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLI 359
|
....*.
gi 1899483498 379 ALFCAV 384
Cdd:cd17333 360 TILYAI 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-190 |
1.39e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGALTk 96
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL- 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVF 176
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG--LSAVF 366
|
170
....*....|....
gi 1899483498 177 WVAVVPGLLAVVLL 190
Cdd:cd06173 367 LLAGALLLLAALLL 380
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
38-394 |
1.60e-05 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 46.59 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRK--WLAVLGYGLGALTKPLFALAPTTGVVLTARLLd 115
Cdd:PRK12382 38 IPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRsaLQGMLACGLAGLAYLLAAILPVSAPFKFALLV- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 116 rVGKGIRGAPRDALVADvtpahlrgaafGLRQSLDTVG-------------AVLGPLLAVGLMLLWSNDFRAVFWVAVVP 182
Cdd:PRK12382 117 -VGRLILGFGESQLLTG-----------ALTWGLGLVGpkhsgkvmswngmAMYGALAAGAPLGLLLHSHFGFAALALTT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 183 GLLAVVLLCVGLREPKLPPtHRRTNPIRRDNLRrlgraYWWVVGIGAVFTLARFSE--AFLVLRAQQSGMALALVPLVMV 260
Cdd:PRK12382 185 MVLPLLAWAFNGTVRKVPA-HAGERPSLWSVVG-----LIWKPGLGLALQGVGFAVigTFVSLYFASKGWAMAGFTLTAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 261 AMNLVyaLSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLR 340
Cdd:PRK12382 259 GGAFV--LMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVR 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1899483498 341 GTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASAR 394
Cdd:PRK12382 337 GTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFR 390
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
9-192 |
1.70e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 9 VLRQIPAGVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYL-GKRKWLAVL 87
Cdd:cd17312 177 FLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAV 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 88 GYGLGA-LTKPLFALAPtTGVVLTARLLDRVGKGIRGAprDALV-----ADVTPAHLRGAAFGLRQSLDTVGAVLGPLLA 161
Cdd:cd17312 257 IYMLLMtLSLALFWFFP-HNKLLSIVLLFLIGFFVGGP--INLIggaaaQDIGRKEAAGTATGFVGLFGYLGASLAGLPL 333
|
170 180 190
....*....|....*....|....*....|.
gi 1899483498 162 VGLMLLWsnDFRAVFWVAVVPGLLAVVLLCV 192
Cdd:cd17312 334 GYIIDHY--GWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
272-391 |
1.95e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.44 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 272 PFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGvhMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVS 351
Cdd:cd17472 51 PFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASI 128
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1899483498 352 GVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMA 391
Cdd:cd17472 129 GIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLF 168
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
70-393 |
2.12e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 70 FSGVLSDYLGKRKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRdALVADVTPAHLRGAAFGLRQ 147
Cdd:cd17504 50 ILGRLGDLYGRKKVLliVLAIYTAGSL---LAAFAPNLPVLIAGRALQGIGGAVFPLAF-ALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 148 SLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCVGlrepklppthrrtnpirrdNLRRLGRAYWWVVGI 227
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLG--WRWIFWTAAPVAVLLAALVPLI-------------------DLRLLRRRNVLLANI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 228 GAVFTLARFSEAF--LVLRAQQ-----SGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVL 300
Cdd:cd17504 185 TALLAGFGMFMVFqlLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 301 AV-HDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGA 379
Cdd:cd17504 265 ALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVP 344
|
330
....*....|....
gi 1899483498 380 LFCAVTLACLMASA 393
Cdd:cd17504 345 TEGAYVLAFLIGAA 358
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
249-388 |
2.16e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 249 GMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQgLLA 328
Cdd:cd17504 27 GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFP-LAF 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 329 AMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLAC 388
Cdd:cd17504 106 ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
206-402 |
2.72e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 206 TNPIRRDNLRRLGRAYWWVVGIGAVFTLARFS----EAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMG 281
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAitsvGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 282 HARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDlRGTAYGFFNLVSGVAMLAASVV 361
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1899483498 362 AGLLWDRFGASFTFYAGALFCAVTLACLMASARARPGGEAA 402
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA 201
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
72-389 |
4.12e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.34 E-value: 4.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 72 GVLSDYLGKRKWLAVLGYGLgALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRdALVADVTPAHLRGAAFGLRQSLDT 151
Cdd:cd17389 85 GAASDVYGRKPVLLLTMIGL-AISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPKKRSKGMALIGVAFS 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 152 VGAVLGPLLAVGLMLLWSND----FRAVFWVAVVPGLLAVVLLCVGLREpKLPpthrrtnpirrDNLRRLGRAYWWVVGI 227
Cdd:cd17389 163 LGFIIGPMIGAYFASFTRSLgevfFSMPALFALVLALADLLFIFFFLPE-TLP-----------SNLRRLGLVYFLYLFL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 228 --GAVFTLARFS-EAFLVLRAQQSGMaLALVPLVMVAMNLVYALSAYPFGKLsdrmghaRLLGWGLAVLIAADLVLAvhd 304
Cdd:cd17389 231 fsGLEFTLTFLThQRFQYTSMQQGKM-FFFIGIIMALVQGGYVRRIKPGKEK-------KAVLQGLILLIPAFLLIG--- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 305 hWAS----VLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGAL 380
Cdd:cd17389 300 -WASsvtvLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGAL 378
|
....*....
gi 1899483498 381 FCAVTLACL 389
Cdd:cd17389 379 LFLLPLLLL 387
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
59-386 |
4.22e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.34 E-value: 4.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 59 MAEATALMVKVFSGVLSDYLGKRKWLAV--LGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPA 136
Cdd:cd17360 43 STVAGAAVGAAIGGWLNDRFGRRPCILLadALFTIGAI---VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 137 HLRGAAFGLRQSLDTVGAVLGPLLAvGLMLLWSNDFRAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTnpirrdnlrR 216
Cdd:cd17360 120 RIRGRLVTINVLFITGGQFVAYVIN-GAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTRRAL---------I 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 217 LGRAYWWVVGIGAVFTLARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYpfgKLSDRMGHARLLGWGLAVLIAA 296
Cdd:cd17360 190 VGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGM---YLIDKFGRRKLLLISLFGVIVA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 297 DLVLAVHDHWASVLAGVALWGVHMGmtqGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFY 376
Cdd:cd17360 267 LVVLAVWLALVGLILYLAFFAPGMG---PVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFL 343
|
330
....*....|
gi 1899483498 377 AGALFCAVTL 386
Cdd:cd17360 344 LFAGLAVLGL 353
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
17-396 |
4.70e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 44.91 E-value: 4.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSmLMDISseMIHSLLPLFMVSaLGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLaVLGYGLGALTK 96
Cdd:cd17390 1 LYLVGFLD-LFGVS--MILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVL-LICLLLTALGY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAPRdALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAvGLMLLWSNDFRAVF 176
Cdd:cd17390 76 VLLGFSTSLALLFLSRIPLGIFKHTQSLCK-AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVG-GHLAETDGGFYYVA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 177 WVAVVPGLLAVVLLCVglrepklppthrrtnpirrdnlrrLGRAYWWVVGIGAVFTLAR--FSEAFLVLRAQQSGMALAL 254
Cdd:cd17390 154 LLCSAIFILNAGLVWF------------------------LLSKLWDLLLVRFLMGFSVllFRSNFSLYLEERFDLSPKT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 255 VPLVMVAMNLVYALSAY---PFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALwGVHMGMTQGLLAAMV 331
Cdd:cd17390 210 IGYLISYSGVLGALSGFlvgRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSLL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1899483498 332 ADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDrFGASFTFYAGALFcaVTLACLMASARAR 396
Cdd:cd17390 289 LSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAVL--ALAAILLMLARQR 350
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
128-370 |
5.02e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.29 E-value: 5.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 128 ALVADVTP-AHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSND-----FRAVFWVAVVPGLLAVVLLCVGLREPKLPP 201
Cdd:cd17332 122 ALIPELTDdPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGnasrgYFLTALIIGIIGIILLLICFFGTRERVVPP 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 202 THRRTNPIRRDNLRRLG--RAYWWVVGIG-AVFTLARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSD 278
Cdd:cd17332 202 EEEKSKLPLLKSLKALLknRPFLILLLAYlLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 279 RMGHARLLGWGLAVLIAADLVLAVHDHWASVL--AGVALWGVHMGMTQGLLAAMVADTAPED-------LRGTAYGFFNL 349
Cdd:cd17332 282 RFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLilVLAVLAGIGYGGANLLPWAMLADVIDYGelktgkrREGIFYSVMTF 361
|
250 260
....*....|....*....|.
gi 1899483498 350 VSGVAMLAASVVAGLLWDRFG 370
Cdd:cd17332 362 FRKLGLALAGALVGLILSLAG 382
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
2-191 |
6.96e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 6.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 2 SAPARLPVLRQIPAGVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKR 81
Cdd:cd17471 186 ATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 82 KWLAVlGYGLGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLrGAAFGLRQSLDTVGAVLGPLLA 161
Cdd:cd17471 266 RLLLA-GFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQP-GLATTLYSNASRIGSLLGGLLA 343
|
170 180 190
....*....|....*....|....*....|
gi 1899483498 162 VGLMLLWSndFRAVFWVAVVPGLLAVVLLC 191
Cdd:cd17471 344 GVIAQYFG--YRAVFLVCAVLALLALVLLL 371
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
70-390 |
7.10e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.80 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 70 FSGVLSDYLGKRK--WLAVLGYGLGALTKPLFALAPTTGVVLTarlldrVGKGIRGA--PRDA-----LVADVTPAHLRG 140
Cdd:cd17337 51 LSGVLAELFGPRRvmLIGLIIWLVFEVLFLAFGLPSHNYPLML------LTYGLRGFgyPLFAysflvWITYRTPAERLG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 141 AAFGLRQSLDTVG-AVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLLCVGLREPklpPTHRRTNPIRRDNLRRLGR 219
Cdd:cd17337 125 SAVGWFWFAFTGGlPVLGSYLASFTIPVIG--EIGTLWLSLVFVALGGLIALFLVRDR---TGEQPLANPSEEPLKELLS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 220 AYWWV-----VGIGAVF----TLARFseAFLVLR----AQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLL 286
Cdd:cd17337 200 GITILfrnpkIAIGGIVriinTLSQF--GFPVFMplyfTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTV 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 287 GWGLAVLIAADLVL-------AVHDHWASVLAGVaLWGVHMGmTQGLLAAMVADTAPEDlRGTAYGFFNLVSGVAMLAAS 359
Cdd:cd17337 278 RWFGGVGCAISTLLfyyvpqlFGHNYWAALIAAI-LFGIGLA-GFVPLSALMPSLAPEH-KGAAMSILNLGAGLSNFVGP 354
|
330 340 350
....*....|....*....|....*....|...
gi 1899483498 360 VVAGLLWDRFGASFTF--YAGALFCAVTLACLM 390
Cdd:cd17337 355 AIVTLFLGSFGAGGVVwiFAGLYLLSAVLTLFL 387
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
43-385 |
1.03e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.19 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 43 VSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWL--AVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKG 120
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLliANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 121 IRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSND-FRAVFWVAVVPGLLAVVLLC-------- 191
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDgWRIPLGLQLVPALLLIIGLLflpesprw 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 192 ---VGLREP---------KLPPTHRRTNPIRR--DNLRRLGRAYWWVVGIGAVFTLARFSEAFLVLRAQQSGMAL----- 252
Cdd:pfam00083 198 lveKGRLEEarevlaklrGVPDVDRELDEIKDslEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAifyys 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 ------------ALVPLVMVAMNLVYALSAYPfgkLSDRMGHARLLGWGLAVLIAADLVLAVH-------DHWASVLAGV 313
Cdd:pfam00083 278 ttifenlglsdsFLVTIIVGVVNFVFTFIAIF---LVDRFGRRPLLLLGAAGMAICFVILGIVallgvskSDWAGIVAIV 354
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899483498 314 A--LWGVHMGMTQG-LLAAMVADTAPEDLRGTAYGFfnlvSGVAMLAASVVAGLLW----DRFGASFTFYAGALFCAVT 385
Cdd:pfam00083 355 FiaLFIAFFAMGWGpVPWVIVSELFPLSVRSKAMAL----ATAANWLANFLIGFLFpiitDAIGLGYTFFIFAGLLVLF 429
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
222-390 |
1.15e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 222 WWVVGIGAVFTLARFSEAFL--VLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLV 299
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFmaIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 300 LAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDrFGASFTFYAGA 379
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAA 160
|
170
....*....|.
gi 1899483498 380 LFCAVTLACLM 390
Cdd:cd17329 161 VLFLLAALVLL 171
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
70-345 |
1.20e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.80 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 70 FSGVLSDYLGKRKWL--AVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQ 147
Cdd:PRK11551 69 LGGRLADRIGRKRILivSVALFGLFSL---ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMY 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 148 SLDTVGAVLGPLlaVGLMLLWSNDFRAVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRL---GRA---- 220
Cdd:PRK11551 146 CGVPFGGALASV--IGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALfgeGRAtatl 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 221 YWWVVGIGAVFTLaRFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVL 300
Cdd:PRK11551 224 LLWISYFFTLIVL-YFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAAL 302
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1899483498 301 AVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYG 345
Cdd:PRK11551 303 AAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVG 347
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-190 |
1.56e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALTK 96
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGV--VLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLaVGLMLLWSNDFRA 174
Cdd:cd17316 258 LPLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPL-IALLLASTGGTGV 336
|
170
....*....|....*.
gi 1899483498 175 VFWVAVVPGLLAVVLL 190
Cdd:cd17316 337 PALILALLAIVALIVA 352
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
72-345 |
1.81e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 43.52 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 72 GVLSDYLGKRKWLaVLGYGLGALTKPLFALAPT--------TGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAF 143
Cdd:cd17368 61 GAYADRIGRKPAM-TLTLAIMALGTLLIALAPTyatigiaaPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 144 GLRQSLDTVGAVLGPLLAVGLMLLWSNDFRAVfWVAVVPGLLAVVLLCVGL----REPKLPPTHRRTNPIRRDNLRRLGR 219
Cdd:cd17368 140 SWQSASQQVAIVAGALVGYLLSLTLTAEALAE-WGWRIPFFIGLLIIPLGLwlrrSLEETEAFLERKARPTRRELFALLA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 220 AYWWVVGIGAVFTLARFSEAFLVL------RAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWG---- 289
Cdd:cd17368 219 NNRRIILLGMLLVAGSTVTFYFTTvytptyAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVItlaa 298
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1899483498 290 LAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYG 345
Cdd:cd17368 299 LVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFS 354
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
240-405 |
2.09e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 240 FLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLA-VHDHWASVLAGVALWGV 318
Cdd:cd17355 25 FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAlATSLWQLYLLWGLLGGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 319 HMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACLMASARARPG 398
Cdd:cd17355 105 GAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPA 184
|
....*..
gi 1899483498 399 GEAARAD 405
Cdd:cd17355 185 DLALRAY 191
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
77-378 |
2.41e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 77 YLGK---RKWLAVLGYGLGALTKPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVG 153
Cdd:cd17328 56 YLGDrynRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 154 AVLGPLLAvGLMLLWSNDFRAVFWVAVVPGLLAVVLLCVGLREPKL-----PPTHRRTNPIRRDNLRRLGR--AYWWVV- 225
Cdd:cd17328 136 SGLGYVVG-GLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRgaaegGVMAKSTATSFLADLKALAKnpSFILSTl 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 226 -GIGAVFT---LARFSEAFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFG-KLSDRMG----HARLLGWGLAVLIAA 296
Cdd:cd17328 215 gFTAVSFVtgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGgILADRLRrktpRADPLVCAVGLLAAA 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 297 DLV----LAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAAS-VVAGLLWDRFGA 371
Cdd:cd17328 295 PFLflalVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSpYLIGLISDLLRQ 374
|
....*..
gi 1899483498 372 SFTFYAG 378
Cdd:cd17328 375 NKDSPLA 381
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
38-388 |
3.80e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 42.33 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWL--AVLGYGLGALTKPLFALAPTTGVVLTARLLD 115
Cdd:TIGR00879 58 FKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLliIALLFVIGAILMGLAAFALSVEMLIVGRVLL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 116 RVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVG-LMLLWSNDFRAVFWVAVVPGLLAVVLLCVGL 194
Cdd:TIGR00879 138 GIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGkVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLP 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 195 REPK---------------------LPPTHR-----RTNPIRRDNLRRLGRAYWW-VVGIGAVFTLARFSEAFLVLRAQQ 247
Cdd:TIGR00879 218 ESPRwlvgkgrveearkslarlrgtSGEDKElldelELIDIKRSIEKRSVQPSWGsLFSSTRRIRRRLFLGVVLQWFQQF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 248 SGMAL-------------------ALVPLVMVAMNLVYALSAYPfgkLSDRMGHARLLGWGLAVLIAADLVLAV------ 302
Cdd:TIGR00879 298 TGINAimyysptifenagvstdhaFLVSIIVGAVNFAFTFVAIF---LVDRFGRRPLLLIGAAGMAICLFVLGIlgasfv 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 303 --HDHWASVLAGV--ALWGVHMGMTQGLLAAM-VADTAPEDLRG-------TAYGFFNLVSGVAMLAASVVAGllwdrFG 370
Cdd:TIGR00879 375 tgSSKSSGNVAIVfiLLFIAFFAMGWGPVPWViVSEIFPLSLRPkgisiavAANWLANFIVGFLFPTMLESIG-----VG 449
|
410
....*....|....*...
gi 1899483498 371 ASFTFYAGalFCAVTLAC 388
Cdd:TIGR00879 450 GVFIFFGG--LNVLGLIF 465
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
253-392 |
5.86e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.84 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 ALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGmTQGLLAAMVA 332
Cdd:cd06179 32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVAS 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 333 DTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASF--TFYAGALFCAVTLACLMAS 392
Cdd:cd06179 111 ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWrwIFYINAIFNALALILLFFF 172
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
34-377 |
7.19e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 41.46 E-value: 7.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 34 IHSLLPLFMVSaLGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLAVLGYGLGA-LTKPLFALAPTTGVVLTAR 112
Cdd:pfam12832 18 LLPYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAvLFLSVLFIPISLTFWWLAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 113 LldRVGKGIRGAPRDALVADVTPAHLRGAA--FGLRQSLDTVG-AVLGPLLAVgLMLLWSNDFRAVFWVAVVPGLLAVVL 189
Cdd:pfam12832 97 L--VVLFSFFWNAILPQFEVATLQHLGEKRkdYGRQRLWGSVGfALSVFGLGA-LFDHYSVGLLPSVLFYLFAALMLLSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 190 LCVGLREPKLPPTHRRTNPIRRDNLRRlgRAYWWVvgIGAVFTLARF---SEAFLVLRAQQSG----MALALVPLVMVAM 262
Cdd:pfam12832 174 LLPLAPPEMEYESKGGSKAVFWNLLKQ--PEVIIF--FLAAFLLGFShgpFYTFLFLYLENLGasntLLGALWALGVVAE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 263 NLVYALSaypfGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGV-ALWGVHMGMTQGLLAAMVADTAPEDLRG 341
Cdd:pfam12832 250 IPLFFYA----HRLLRRFGHRNLLIIALLLTALRWLLYAFFVENPWLVLPIqFLHAISFGLTHAAAIEYVRRIFPGSLQG 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 1899483498 342 TAYGFFNLVS-GVAMLAASVVAGLLWDRFGASFTFYA 377
Cdd:pfam12832 326 TGQALYSGLYfGLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
64-387 |
8.70e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.41 E-value: 8.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 64 ALMVKVFSGVLSDYLGKRK--WLAVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGA 141
Cdd:cd17358 54 ALIGALLSGKLADRIGRKRtlLISAIPCILGWL---LIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 142 AFGLRQSLDTVGAVLGplLAVGLMLLWsndfRAVFWVAVVPGLLAVVLLC-----------VGLRE-------------- 196
Cdd:cd17358 131 LGSLNQLLVNIGILLG--YVLGSFLPW----RTLALIGAIPPVVFLILLFfipesprwlakKGREEeaekslqflrgkda 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 197 ---PKLPP-------THRRTNPIRRDNLRRlgRAYWWVVGIGAVFTLAR---------------FSEAFLVLRAQQSGMA 251
Cdd:cd17358 205 disKEAAEiqeelaeLEKEAKESSFSDLFQ--RKYLKPLVIGLGLMLFQqlsginavifyassiFDEAGSGLDPNTATII 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 252 LALVPLVMVAMNLVyalsaypfgkLSDRMGHARLL-----GWGLAVLIAA-------DLVLAVHDHW---ASVLAGVALW 316
Cdd:cd17358 283 IGVVQVVGTLVATL----------LVDRLGRRPLLlvsaiGMGIGLLALGlyfylqeHGALLSSVSWlplVGLVIYIISF 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899483498 317 GVHMGmtqGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA 387
Cdd:cd17358 353 SIGLG---PLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALV 420
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-384 |
8.70e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 8.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 18 WVLGFVSMLMDISSEMIHSLLPLFMV---SALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRkWLAVLGYGLGAL 94
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIpiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPR-RVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 95 TKPLFALAPT-TGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLaVGLMLLWSNDFR 173
Cdd:cd17355 81 GLVLLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPL-GAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 174 AVFWVAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRA-----YWWVVGIgavFTLARFSEAFLVLR---- 244
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEAlrsasFWLLALA---FFLCGFAVVGLIVHlvpy 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 245 AQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAG-VALWGVHMGMT 323
Cdd:cd17355 237 LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 324 QGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGA-SFTFYAGALFCAV 384
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSyTAAWALAVALGLI 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
266-391 |
9.20e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.07 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 266 YALSAYPFGKLSDRMGHARLLGWGlaVLIAADLVL----AVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAPEDLRG 341
Cdd:cd17318 69 YILTQIPGGYLAEKYGAKRVLGYS--ILITALLTLltplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERS 146
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1899483498 342 TAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYagaLFCAVTLACLMA 391
Cdd:cd17318 147 RLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY---IFGGLGLLWCLL 193
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
239-386 |
1.05e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 239 AFLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGV 318
Cdd:cd17316 22 APVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGI 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 319 HMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASF----TFYAGALFCAVTL 386
Cdd:cd17316 102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwriLFLIGALPALLAL 173
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
17-389 |
1.38e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 17 VWVLGFVSMLMDISSEMIHSLLPlFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRKWLaVLGYGLGALTK 96
Cdd:cd17331 2 LLIVHLNIVLYATCYWLQQPVLP-YLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAAL-VLSFLSSALSY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFALAPTTGVVLTARLLDRVGKGIRGAprDALVADVTPAHLRGAAFGlRQSLD-TVGAVLGPLLavGLMLLWSNDFRAV 175
Cdd:cd17331 80 LLLAFASSVPMLFLSRLPSVFMHAMQAA--QMVVTDLTDPGERAAALG-RLGLSyGIGMVVGSFL--GGLLTKKFGEQAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 176 FWVAVVPGLLAVVLLCVGLREPKLPPTHRRTN----PIRRDNLRRLGR-------AYWWVVGIGAVFTLARFSEAFLV-- 242
Cdd:cd17331 155 ALVAAVGSLLSIVLVILLIPSNTKSKREKEAKesasPPSVFNLKEILRllrlpgvAFLLLVKLLSGLPIGMFQSMFSLva 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 243 -----LRAQQSGMALALVPLVMVAMNLVYAlsaypfGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWG 317
Cdd:cd17331 235 mdffgLTPEENGYLMSYAGVLGMVVQGLLV------GPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLV 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1899483498 318 VHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACL 389
Cdd:cd17331 309 IGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYL 380
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
240-389 |
2.11e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 240 FLVLRAQQSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIA--ADLVLAVHDHWASVLAGVALWG 317
Cdd:cd17352 205 YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILglSLLAFPLATTYVGLIVFSVLFG 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899483498 318 VHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGA-SFTFYAGALFCAVTLACL 389
Cdd:cd17352 285 FCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyDAAFYFCGACLLLSGVLL 357
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
246-405 |
2.32e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 246 QQSGMALALVPLVMVAMNLVYALSAYPFGKLSDR----MGHARLLGWGLAVLIA---------ADLVLAVHDH---WASV 309
Cdd:cd17313 27 QTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRPFILVGAPLAAlglilipnaADIGLALGDGprtWALV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 310 LA--GVALWGVHMGMTQGLLAAMVADTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFT--------FYAGA 379
Cdd:cd17313 107 LFvlGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFAlggnlkvpFYIGA 186
|
170 180
....*....|....*....|....*.
gi 1899483498 380 LFCAVTLACLMASARARPGGEAARAD 405
Cdd:cd17313 187 IILLVCVLVTLFFVKEPPLSPEAGEH 212
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-189 |
3.15e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 16 GVWVLGFVSMLMDISSEMIHSLLPLFMVSALGASAlvvGIVEGMAEATALMVKVFSGVLSDYLGkRKWLAVLGYGLGALT 95
Cdd:cd17489 195 KVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLSDRKG-PKTVIIPGLLLLALG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 96 KPLFALAPTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAV 175
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAM 348
|
170
....*....|....
gi 1899483498 176 FWVAVVPGLLAVVL 189
Cdd:cd17489 349 FLLAAVVVLLALVL 362
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
38-402 |
3.81e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 39.10 E-value: 3.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRK---------WLAVLGYGLGALTKPLFALAptTGVV 108
Cdd:PRK05122 38 LPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKavvfglcgcALSGLLYLLAGLLAAWPVLS--LLLL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 109 LTARLLDRVGK------------GIRGAPRDALVADVTPAHLRGAAfglrqsldTVGAVLGPLLA--VGLMLLwsndfra 174
Cdd:PRK05122 116 LLGRLLLGIGEslagtgsilwgiGRVGALHTGRVISWNGIATYGAL--------AIGAPLGVLLYhwGGLAGL------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 175 vfwvAVVPGLLAVVLLCVGLREPKLPPTHRRTNPIRrdnlRRLGRAywWVVGIGAVFTLARFS--EAFLVLRAQQSGMAL 252
Cdd:PRK05122 181 ----GLLIMLLALLGLLLARPRPAVPPVKGERLPFR----RVLGRV--WPYGMGLALASIGFGtiATFITLYYAARGWDG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 253 AlvPLVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVA 332
Cdd:PRK05122 251 A--ALALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAV 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1899483498 333 DTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLA-CLMASARARPGGEAA 402
Cdd:PRK05122 329 KRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLAlTWLLYRRAPRAVPEA 399
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
257-389 |
6.89e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.51 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 257 LVMVAMNLVYALSAYPFGKLSDRMGHARLLGWGLAVLIAADLVLAVHDHWASVLAGVALWGVHMGMTQGLLAAMVADTAP 336
Cdd:TIGR00881 34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1899483498 337 EDLRGTAYGFFNLVS--GVAMLAASVVAGLLWDRFGASFTFYAGALFCAVTLACL 389
Cdd:TIGR00881 114 RSERGTWVSFWNCSHnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICF 168
|
|
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
38-190 |
7.08e-03 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 38.32 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 38 LPLFMVSALGASALVVGIVEGMAEATALMVKVFSGVLSDYLGKRkWLAVLGYGLGALTKPLFALAPTTGVVLTARLLDRV 117
Cdd:PRK15011 239 MPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKR-FLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAI 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1899483498 118 GKGIRGAPRDALVADVTPAHlRGAAFGLRQSLDTVGAVLGPLLAVGLMLLWSndFRAVFWVAVVPGLLAVVLL 190
Cdd:PRK15011 318 YIGILGGIGMLYFQDLMPGQ-AGSATTLYTNTSRVGWIIAGSLAGIVAEIWN--YHAVFWFALVMIIATLFCL 387
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
22-286 |
7.34e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 38.35 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 22 FVSMLMDISSEMIHSLL-PLFMVSAL--GASALVVGIVEGMaeaTALMVKVFSGVLSDYLGK--RKWLAVLGYGLGALTK 96
Cdd:cd17385 2 ISLALANFSSMICYSILaPFFPREAEkkGVSDTIIGLVFGC---FALVIFLTSPIFGKYLVKigAKFMFVAGMFVSGGCT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 97 PLFAL---APTTGVVL----TARLLDRVGKGIRGAPRDALVADVTPAHLrGAAFGLRQSLDTVGAVLGPllAVGLMLLWS 169
Cdd:cd17385 79 ILFGFldrVPDGTVFIalcfLVRIVEAVGFAAFITASFAIIAKEFPNNI-ATVLGTLETFSGLGLMLGP--PLGGFLYQA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 170 NDFRAVFWVavvpgLLAVVLLCVGLREPKLPPTHRRTNPIRRDNLRRLGRAYWWVVGIgAVFTLAR---FSEAFLVLRAQ 246
Cdd:cd17385 156 GGYELPFLV-----LGCLLLLTVPLNMFILPRYDDDPSPKSGSMLKLLKIPSVLLLCL-SIVSGSVslgFLDPTLSPHLR 229
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1899483498 247 QSGMALALVPLVMVAMNLVYALSAYPFGKLSDRMGHARLL 286
Cdd:cd17385 230 QFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWL 269
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
20-373 |
8.28e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 38.25 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 20 LGFVSMLMDISSEMIHSLLPLFMVSALGASALVVGIVEGMAEATAlMVKVFSGVLSDYLGKRK-------WLAVLGYGLG 92
Cdd:cd06176 5 LGLFQVALGMMVVLTTGTLNRVMIVELGLPATLVGLLIALHYLVA-PLRVWIGHRSDTHPLRGyrrtpyiWLGMLLLALG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 93 ALTKPLFAL-------APTTGVVLTARLLDRVGKGIRGAPRDALVADVTPAHLRGAAFGLRQSLDTVGAVLGPLLAVGLM 165
Cdd:cd06176 84 LALAPFAALllagaafWLGLALAVLAFLLYGIGVGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 166 LLWSNDfrAVFWVAVVPGLLAVVLLCVGLR--EPKLPPTHRRTNPIRRDNLRRLGRAYW---------WVVGIGavfTLA 234
Cdd:cd06176 164 DPYSPE--RLIQVFQIVALVALLLALLALWgvERRRSRAALAAEEAPPETFREALRLLWaspqarrffIFLFLS---TLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 235 RFSEAFL--VLRAQQSGMALA----LVPLVMVAMNLVYALSAYPFGKlsdRMGHARLLGWGLAVLIAADLVLAVHDHWAS 308
Cdd:cd06176 239 LFMQDVIlePFGGEVFGMSVGettrLTAIWGGGTLLGMLLAGFLLSR---RLGKKRTAALGCLLSALGFLLLALAGLLGN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1899483498 309 V---LAGVALWGVHMGM-TQGLLAAMVaDTAPEDLRGTAYGFFNLVSGVAMLAASVVAGLLWDRFGASF 373
Cdd:cd06176 316 PwlfRPGVFLLGLGNGLfTVGALTLMM-DLTGEGTAGLFMGLWGAAQALARGLGTLLGGALRDLLRALF 383
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
266-377 |
8.45e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 8.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 266 YALSAYPFGKLSDRMGHARLLGWGLAVLIAADLV--LAVHDHWASVLAGVALwgvhMGMTQGL----LAAMVADTAPEDL 339
Cdd:cd17380 47 YALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRIL----LGLGEGVhfpsMTSLFSRWVPVSE 122
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1899483498 340 RGTAYGFfnLVSGVAM--LAASVVAGLLWDRFGASFTFYA 377
Cdd:cd17380 123 RSRAVSI--VTAGSYLgtLLGGLIGPLLLEYYGWPSVFYF 160
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
49-157 |
8.99e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.10 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1899483498 49 SALVVGIVEGMAEATALMVKVFSGVLSDYLGKRK--WLAVLGYGLGALtkpLFALAPTTGVVLTARLLDRVGKGIRGAPR 126
Cdd:cd17362 37 SSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKelILAALLYLVGSL---VTGLAPSYPVLLVGRLIYGVGIGLAMHAA 113
|
90 100 110
....*....|....*....|....*....|.
gi 1899483498 127 DALVADVTPAHLRGAAFGLRQSLDTVGAVLG 157
Cdd:cd17362 114 PVYIAETSPSHIRGLLVSLKELFIVLGILLG 144
|
|
| |
