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molecular chaperone HtpG [Xanthomonas sp. GW]
Protein Classification
Hsp90 family chaperone protein ( domain architecture ID 11480452 )
Hsp90 (heat shock protein 90) family chaperone protein, such as molecular chaperone HtpG (high-temperature protein G) that facilitates the folding and conformational changes of a wide array of proteins
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
5-634
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1048.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 5 TQK ET LG FQ T EVKQLL Q LMIHSLYSNKEIFLRELISNASDA A DKLRFEAL VK P E L LD GD AQ L R IRI G FDK D A G T V TI D DN 84
Cdd:PRK05218 1 MAM ET GE FQ A EVKQLL H LMIHSLYSNKEIFLRELISNASDA I DKLRFEAL TD P A L YE GD GD L K IRI S FDK E A R T L TI S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 85 GIGM S REE IVSH LGTIAKSGT SD FL KH L S GDQKKDS H LIGQFGVGFYSAF I VAD Q V D V YS R R AG l PA S E G V H W S S R GEGE 164
Cdd:PRK05218 81 GIGM T REE VIEN LGTIAKSGT KE FL EK L K GDQKKDS Q LIGQFGVGFYSAF M VAD K V T V IT R S AG - PA A E A V R W E S D GEGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 165 FEVAT I D K P ERGT R I V L Q LKE S ED S F A D G W KL R G I VR KYSD H I AL PI E L P KE hhgedkdkpetp E W ET V N R ASALWTR PR 244
Cdd:PRK05218 160 YTIEE I E K E ERGT E I T L H LKE D ED E F L D E W RI R S I IK KYSD F I PV PI K L E KE ------------ E E ET I N S ASALWTR SK 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 245 T EI K DEEY Q E L YKH I AHD HEN P VA W S HN K VEG KLD YT S LLY V P GR APFDL YQ RD ASR GLKLYV Q RVFIMD Q AE QF LP L YL 324
Cdd:PRK05218 228 S EI T DEEY K E F YKH L AHD FDD P LF W I HN N VEG PFE YT G LLY I P KK APFDL FN RD RKG GLKLYV K RVFIMD D AE EL LP E YL 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 325 RFVKG IV DS S DLPLNVSREILQ SGP V IDSMKS A L TK RA LD M LEKLAK DEP E R Y KSV WK N FG Q VLKEG PA EDFANREK I A G 404
Cdd:PRK05218 308 RFVKG VI DS E DLPLNVSREILQ EDR V VKKIRK A I TK KV LD E LEKLAK NDR E K Y EKF WK E FG P VLKEG LY EDFANREK L A K 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 405 LLRFASTH sgd AEHS V A LA D YV A RMK D GQ D K L YY LS G E S YAQI K D SPHLE V F R KKGIEVLLLTD R IDE WLM SYL T EFDGK 484
Cdd:PRK05218 388 LLRFASTH --- EGKY V S LA E YV E RMK E GQ K K I YY IT G D S REAA K N SPHLE L F K KKGIEVLLLTD P IDE FWI SYL E EFDGK 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 485 S F VD VARGDLDLGK L D s D EEK QAM EEA AKAKRG L V ER IQQ ALG ED V SE VR V SHRLTDSPA I L AIGQ GD LGL QM RQI L E A S 564
Cdd:PRK05218 465 P F KS VARGDLDLGK E D - E EEK EEK EEA EEEFKP L L ER LKE ALG DK V KD VR L SHRLTDSPA C L VADE GD MST QM EKL L K A A 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 565 GQ KL PESKP VF E F NP A HPL IE KL DA EAD GER F G DLA RV L F DQA A LA A G D SL K DPAA Y V R RLN K LLL E L S A 634
Cdd:PRK05218 544 GQ EV PESKP IL E I NP N HPL VK KL AD EAD EAK F K DLA EL L Y DQA L LA E G G SL E DPAA F V K RLN E LLL K L L A 613
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
5-634
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1048.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 5 TQK ET LG FQ T EVKQLL Q LMIHSLYSNKEIFLRELISNASDA A DKLRFEAL VK P E L LD GD AQ L R IRI G FDK D A G T V TI D DN 84
Cdd:PRK05218 1 MAM ET GE FQ A EVKQLL H LMIHSLYSNKEIFLRELISNASDA I DKLRFEAL TD P A L YE GD GD L K IRI S FDK E A R T L TI S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 85 GIGM S REE IVSH LGTIAKSGT SD FL KH L S GDQKKDS H LIGQFGVGFYSAF I VAD Q V D V YS R R AG l PA S E G V H W S S R GEGE 164
Cdd:PRK05218 81 GIGM T REE VIEN LGTIAKSGT KE FL EK L K GDQKKDS Q LIGQFGVGFYSAF M VAD K V T V IT R S AG - PA A E A V R W E S D GEGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 165 FEVAT I D K P ERGT R I V L Q LKE S ED S F A D G W KL R G I VR KYSD H I AL PI E L P KE hhgedkdkpetp E W ET V N R ASALWTR PR 244
Cdd:PRK05218 160 YTIEE I E K E ERGT E I T L H LKE D ED E F L D E W RI R S I IK KYSD F I PV PI K L E KE ------------ E E ET I N S ASALWTR SK 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 245 T EI K DEEY Q E L YKH I AHD HEN P VA W S HN K VEG KLD YT S LLY V P GR APFDL YQ RD ASR GLKLYV Q RVFIMD Q AE QF LP L YL 324
Cdd:PRK05218 228 S EI T DEEY K E F YKH L AHD FDD P LF W I HN N VEG PFE YT G LLY I P KK APFDL FN RD RKG GLKLYV K RVFIMD D AE EL LP E YL 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 325 RFVKG IV DS S DLPLNVSREILQ SGP V IDSMKS A L TK RA LD M LEKLAK DEP E R Y KSV WK N FG Q VLKEG PA EDFANREK I A G 404
Cdd:PRK05218 308 RFVKG VI DS E DLPLNVSREILQ EDR V VKKIRK A I TK KV LD E LEKLAK NDR E K Y EKF WK E FG P VLKEG LY EDFANREK L A K 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 405 LLRFASTH sgd AEHS V A LA D YV A RMK D GQ D K L YY LS G E S YAQI K D SPHLE V F R KKGIEVLLLTD R IDE WLM SYL T EFDGK 484
Cdd:PRK05218 388 LLRFASTH --- EGKY V S LA E YV E RMK E GQ K K I YY IT G D S REAA K N SPHLE L F K KKGIEVLLLTD P IDE FWI SYL E EFDGK 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 485 S F VD VARGDLDLGK L D s D EEK QAM EEA AKAKRG L V ER IQQ ALG ED V SE VR V SHRLTDSPA I L AIGQ GD LGL QM RQI L E A S 564
Cdd:PRK05218 465 P F KS VARGDLDLGK E D - E EEK EEK EEA EEEFKP L L ER LKE ALG DK V KD VR L SHRLTDSPA C L VADE GD MST QM EKL L K A A 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 565 GQ KL PESKP VF E F NP A HPL IE KL DA EAD GER F G DLA RV L F DQA A LA A G D SL K DPAA Y V R RLN K LLL E L S A 634
Cdd:PRK05218 544 GQ EV PESKP IL E I NP N HPL VK KL AD EAD EAK F K DLA EL L Y DQA L LA E G G SL E DPAA F V K RLN E LLL K L L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
5-634
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 1005.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 5 TQ KET LG FQ T EVKQLL Q LMIHSLYSNKEIFLRELISNASDA A DKLRF E AL VK PEL LDG D AQ L R IRI GF DK D A G T V TI D DN 84
Cdd:COG0326 1 MA KET GE FQ A EVKQLL D LMIHSLYSNKEIFLRELISNASDA I DKLRF L AL TD PEL KEE D GD L K IRI EV DK E A K T L TI S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 85 GIGM S REE IVSH LGTIAKSGT SD FL KH L S GDQKKDS H LIGQFGVGFYSAF I VAD Q V D V YS R R AG LP A s E G V H W S S R G E GE 164
Cdd:COG0326 81 GIGM T REE VIEN LGTIAKSGT RE FL EK L K GDQKKDS D LIGQFGVGFYSAF M VAD K V E V VT R S AG ED A - E A V R W E S D G D GE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 165 FEVATID K P ERGT R I V L Q LKE SEDS F ADG W K LR G I VR KYSD H I AL PI ELPK E hhgedkd KP ET P E W ET V N R A S ALWTR PR 244
Cdd:COG0326 160 YTIEEAE K A ERGT E I T L H LKE DAEE F LEE W R LR E I IK KYSD F I PV PI KMEG E ------- EE ET E E D ET I N S A T ALWTR SK 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 245 T EI K DEEY Q E L YKH IA HD H E N P VA W S H NK VEG KLD YT S LLY V P GR APFDLY Q RD ASR G L KLYV Q RVFIMD Q AE QF LP L YL 324
Cdd:COG0326 233 S EI T DEEY K E F YKH LF HD F E D P LF W I H LN VEG PFE YT G LLY I P KK APFDLY D RD RKG G I KLYV K RVFIMD D AE DL LP E YL 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 325 RFV K G I VDS S DLPLNVSREILQ SGPVIDSMKS A L TK RA LD M LEKLAK DEP E R Y KSV WK N FG Q VLKEG PA EDF A NREKIA G 404
Cdd:COG0326 313 RFV R G V VDS P DLPLNVSREILQ EDRQLKKIRK A I TK KV LD E LEKLAK NDR E K Y EKF WK E FG L VLKEG AL EDF K NREKIA D 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 405 LLRF A ST H sgd AEHS V A LA D YV A RMK D GQ D K L YY LS GES YAQIKD SPHLE V F RK KGIEVLLLTD R IDE W L M S Y L T EFDGK 484
Cdd:COG0326 393 LLRF E ST K --- EGGY V T LA E YV E RMK E GQ K K I YY IT GES REAAEQ SPHLE I F KA KGIEVLLLTD P IDE F L I S H L E EFDGK 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 485 S F VD V AR GDLDL G KL dsd EEK QAM EE AAKAKRG L V ER IQQ ALG ED V SE VRVS H RLTDSPA I L AIGQ GD LGLQ M RQI L E A S 564
Cdd:COG0326 470 K F KS V DS GDLDL D KL --- EEK KES EE EEEEFKP L L ER FKE ALG DK V KD VRVS A RLTDSPA C L VADE GD MSRR M EKM L K A M 546
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 565 GQ KL PE S KP VF E F NP A HPL IE KL D AE A D G E R F G DLA RV L F DQA A LA A G DS L K DPAA Y V R RLNKLL LELSA 634
Cdd:COG0326 547 GQ DM PE A KP IL E I NP N HPL VK KL A AE E D E E L F K DLA EL L Y DQA L LA E G GL L E DPAA F V K RLNKLL EKALG 616
HSP90
pfam00183 Hsp90 protein;
195-629
8.03e-152
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 448.16
E-value: 8.03e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 195 K LRGI V R KYS DH I AL PI E L ---------------------------- PK - E HHG E DKD K PE T ------- P EWE TV N RASA 238
Cdd:pfam00183 7 K IKEL V K KYS EF I NF PI Y L wvekeeevevpdeeeeeeeeeeeeeddd PK v E EED E EEE K KK T kkvketv W EWE LL N KTKP 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 239 L WTR PRT E IKD EEY Q E L YK HIAH D H E N P V A WS H NK VEG KLDYT SLL YV P G RAPFDL YQRDA - SRGL KLYV Q RVFI M D QA E 317
Cdd:pfam00183 87 I WTR NPK E VTE EEY A E F YK SLSK D W E D P L A VK H FS VEG EVEFK SLL FI P K RAPFDL FENKK k KNNI KLYV R RVFI T D DF E 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 318 QFL P L YL R FVKG I VDS S DLPLNVSRE I LQ SGPVIDSM K SA L TKR ALDM LEKL A KDE p E R YK SV WK N FG QV LK E G PA ED FA 397
Cdd:pfam00183 167 DLI P E YL N FVKG V VDS D DLPLNVSRE T LQ QNKILKVI K KK L VRK ALDM FKEI A EEK - E D YK KF WK E FG KN LK L G II ED SS 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 398 NR E K I A G LLRF A S TH SGD ae HSVA L A DYV A RMK D GQ DKL YY LS GES YAQIKD SP H LE VFR KKG I EVL L LTD R IDE WLMSY 477
Cdd:pfam00183 246 NR N K L A K LLRF Y S SK SGD -- ELTS L D DYV S RMK E GQ KHI YY IT GES KEEVEN SP F LE RLK KKG Y EVL Y LTD P IDE YAVQQ 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 478 L T EFDGK SF V D VA RGD L D L G kl DSD EEK QAM EE AA K AKRG L VERIQQA LG ED V SE V R VS H RL T DSP AI L AIG Q GDLGLQ M 557
Cdd:pfam00183 324 L K EFDGK KL V N VA KEG L E L E -- EDE EEK KKD EE LK K EFEP L TKWLKDV LG DK V EK V V VS N RL V DSP CV L VTS Q YGWSAN M 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 558 RQ I LE A ------- S GQKLPE SK PVF E F NP A HP L I EK L ---- D A EA D GERFG DLA RV L FDQ A A L AA G D SL K DPA AYVR R LN 626
Cdd:pfam00183 402 ER I MK A qalrkds S MSSYMS SK KTL E I NP R HP I I KE L lkrv E A DK D DKTAK DLA LL L YET A L L RS G F SL E DPA SFAS R IY 481
...
gi 1893323920 627 KL L 629
Cdd:pfam00183 482 RM L 484
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
17-207
5.20e-98
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 297.51
E-value: 5.20e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 17 K QLL Q L M IHSLYSNKEIFLRELISNASDA A DKLR FEA L VK P E LLD G D AQ L R IRI GF DK DAG T V TI D D N GIGM SR EE IVSH 96
Cdd:cd16927 1 N QLL D L I IHSLYSNKEIFLRELISNASDA L DKLR YLS L TD P S LLD D D PE L E IRI SP DK ENR T L TI S D T GIGM TK EE LINN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 97 LGTIA K SGT SD FL KH L S g DQK KDS H LIGQFGVGFYSAF I VAD Q V D V YSRR AG lp AS EG VH W S S R G E G EFEVATIDK - PE R 175
Cdd:cd16927 81 LGTIA R SGT KA FL EA L Q - EGA KDS D LIGQFGVGFYSAF M VAD K V T V TTKS AG -- DD EG YR W E S D G G G SYTIEEAEG e LG R 157
170 180 190
....*....|....*....|....*....|..
gi 1893323920 176 GT R I V L Q LKE SEDS F ADGWKLRGI V R KYSD H I 207
Cdd:cd16927 158 GT K I T L H LKE DAKE F LEEARIKEL V K KYSD F I 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
30-184
3.67e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 60.36
E-value: 3.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 30 NKEIF LR ELI SN AS D A A D K LRF E alvkpelldg DAQLRIRIGF D K D AGTV T ID DNG I G MS r E E IVSHL gtiaksgtsd F L 109
Cdd:smart00387 1 GDPDR LR QVL SN LL D N A I K YTP E ---------- GGRITVTLER D G D HVEI T VE DNG P G IP - P E DLEKI ---------- F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1893323920 110 KHLSG D qk K D S HL IG QF G V G FYSAFIVADQV dvysrraglpasegvhwssrg E GE FE V at IDK P ER GT RIVLQ L K 184
Cdd:smart00387 60 PFFRT D -- K R S RK IG GT G L G LSIVKKLVELH --------------------- G GE IS V -- ESE P GG GT TFTIT L P 109
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
5-634
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1048.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 5 TQK ET LG FQ T EVKQLL Q LMIHSLYSNKEIFLRELISNASDA A DKLRFEAL VK P E L LD GD AQ L R IRI G FDK D A G T V TI D DN 84
Cdd:PRK05218 1 MAM ET GE FQ A EVKQLL H LMIHSLYSNKEIFLRELISNASDA I DKLRFEAL TD P A L YE GD GD L K IRI S FDK E A R T L TI S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 85 GIGM S REE IVSH LGTIAKSGT SD FL KH L S GDQKKDS H LIGQFGVGFYSAF I VAD Q V D V YS R R AG l PA S E G V H W S S R GEGE 164
Cdd:PRK05218 81 GIGM T REE VIEN LGTIAKSGT KE FL EK L K GDQKKDS Q LIGQFGVGFYSAF M VAD K V T V IT R S AG - PA A E A V R W E S D GEGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 165 FEVAT I D K P ERGT R I V L Q LKE S ED S F A D G W KL R G I VR KYSD H I AL PI E L P KE hhgedkdkpetp E W ET V N R ASALWTR PR 244
Cdd:PRK05218 160 YTIEE I E K E ERGT E I T L H LKE D ED E F L D E W RI R S I IK KYSD F I PV PI K L E KE ------------ E E ET I N S ASALWTR SK 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 245 T EI K DEEY Q E L YKH I AHD HEN P VA W S HN K VEG KLD YT S LLY V P GR APFDL YQ RD ASR GLKLYV Q RVFIMD Q AE QF LP L YL 324
Cdd:PRK05218 228 S EI T DEEY K E F YKH L AHD FDD P LF W I HN N VEG PFE YT G LLY I P KK APFDL FN RD RKG GLKLYV K RVFIMD D AE EL LP E YL 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 325 RFVKG IV DS S DLPLNVSREILQ SGP V IDSMKS A L TK RA LD M LEKLAK DEP E R Y KSV WK N FG Q VLKEG PA EDFANREK I A G 404
Cdd:PRK05218 308 RFVKG VI DS E DLPLNVSREILQ EDR V VKKIRK A I TK KV LD E LEKLAK NDR E K Y EKF WK E FG P VLKEG LY EDFANREK L A K 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 405 LLRFASTH sgd AEHS V A LA D YV A RMK D GQ D K L YY LS G E S YAQI K D SPHLE V F R KKGIEVLLLTD R IDE WLM SYL T EFDGK 484
Cdd:PRK05218 388 LLRFASTH --- EGKY V S LA E YV E RMK E GQ K K I YY IT G D S REAA K N SPHLE L F K KKGIEVLLLTD P IDE FWI SYL E EFDGK 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 485 S F VD VARGDLDLGK L D s D EEK QAM EEA AKAKRG L V ER IQQ ALG ED V SE VR V SHRLTDSPA I L AIGQ GD LGL QM RQI L E A S 564
Cdd:PRK05218 465 P F KS VARGDLDLGK E D - E EEK EEK EEA EEEFKP L L ER LKE ALG DK V KD VR L SHRLTDSPA C L VADE GD MST QM EKL L K A A 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 565 GQ KL PESKP VF E F NP A HPL IE KL DA EAD GER F G DLA RV L F DQA A LA A G D SL K DPAA Y V R RLN K LLL E L S A 634
Cdd:PRK05218 544 GQ EV PESKP IL E I NP N HPL VK KL AD EAD EAK F K DLA EL L Y DQA L LA E G G SL E DPAA F V K RLN E LLL K L L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
5-634
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 1005.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 5 TQ KET LG FQ T EVKQLL Q LMIHSLYSNKEIFLRELISNASDA A DKLRF E AL VK PEL LDG D AQ L R IRI GF DK D A G T V TI D DN 84
Cdd:COG0326 1 MA KET GE FQ A EVKQLL D LMIHSLYSNKEIFLRELISNASDA I DKLRF L AL TD PEL KEE D GD L K IRI EV DK E A K T L TI S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 85 GIGM S REE IVSH LGTIAKSGT SD FL KH L S GDQKKDS H LIGQFGVGFYSAF I VAD Q V D V YS R R AG LP A s E G V H W S S R G E GE 164
Cdd:COG0326 81 GIGM T REE VIEN LGTIAKSGT RE FL EK L K GDQKKDS D LIGQFGVGFYSAF M VAD K V E V VT R S AG ED A - E A V R W E S D G D GE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 165 FEVATID K P ERGT R I V L Q LKE SEDS F ADG W K LR G I VR KYSD H I AL PI ELPK E hhgedkd KP ET P E W ET V N R A S ALWTR PR 244
Cdd:COG0326 160 YTIEEAE K A ERGT E I T L H LKE DAEE F LEE W R LR E I IK KYSD F I PV PI KMEG E ------- EE ET E E D ET I N S A T ALWTR SK 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 245 T EI K DEEY Q E L YKH IA HD H E N P VA W S H NK VEG KLD YT S LLY V P GR APFDLY Q RD ASR G L KLYV Q RVFIMD Q AE QF LP L YL 324
Cdd:COG0326 233 S EI T DEEY K E F YKH LF HD F E D P LF W I H LN VEG PFE YT G LLY I P KK APFDLY D RD RKG G I KLYV K RVFIMD D AE DL LP E YL 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 325 RFV K G I VDS S DLPLNVSREILQ SGPVIDSMKS A L TK RA LD M LEKLAK DEP E R Y KSV WK N FG Q VLKEG PA EDF A NREKIA G 404
Cdd:COG0326 313 RFV R G V VDS P DLPLNVSREILQ EDRQLKKIRK A I TK KV LD E LEKLAK NDR E K Y EKF WK E FG L VLKEG AL EDF K NREKIA D 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 405 LLRF A ST H sgd AEHS V A LA D YV A RMK D GQ D K L YY LS GES YAQIKD SPHLE V F RK KGIEVLLLTD R IDE W L M S Y L T EFDGK 484
Cdd:COG0326 393 LLRF E ST K --- EGGY V T LA E YV E RMK E GQ K K I YY IT GES REAAEQ SPHLE I F KA KGIEVLLLTD P IDE F L I S H L E EFDGK 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 485 S F VD V AR GDLDL G KL dsd EEK QAM EE AAKAKRG L V ER IQQ ALG ED V SE VRVS H RLTDSPA I L AIGQ GD LGLQ M RQI L E A S 564
Cdd:COG0326 470 K F KS V DS GDLDL D KL --- EEK KES EE EEEEFKP L L ER FKE ALG DK V KD VRVS A RLTDSPA C L VADE GD MSRR M EKM L K A M 546
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 565 GQ KL PE S KP VF E F NP A HPL IE KL D AE A D G E R F G DLA RV L F DQA A LA A G DS L K DPAA Y V R RLNKLL LELSA 634
Cdd:COG0326 547 GQ DM PE A KP IL E I NP N HPL VK KL A AE E D E E L F K DLA EL L Y DQA L LA E G GL L E DPAA F V K RLNKLL EKALG 616
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
8-629
1.98e-174
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 512.68
E-value: 1.98e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 8 ET LG FQ T E VK QL LQ L M I HSL YSNKEIFLRELISNASDA A DK L R FEA L VK P EL L DGDAQ L R IR IGF DK DAG T V T ID DNGIG 87
Cdd:PTZ00272 3 ET FA FQ A E IN QL MS L I I NTF YSNKEIFLRELISNASDA C DK I R YQS L TD P SV L GESPR L C IR VVP DK ENK T L T VE DNGIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 88 M SREEI V SH LGTIA K SGT SD F LKH L sg DQKK D SHL IGQFGVGFYSA FI VAD Q V D V Y S RRA glp AS E GVH W S S RGE G E F EV 167
Cdd:PTZ00272 83 M TKADL V NN LGTIA R SGT KA F MEA L -- EAGG D MSM IGQFGVGFYSA YL VAD R V T V T S KNN --- SD E SYV W E S SAG G T F TI 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 168 ATIDKPE -- RGTRI V L Q LKE SEDSFADGWK L RGIVR K Y S DH I ALP IEL --------------------------- PK --- 215
Cdd:PTZ00272 158 TSTPESD mk RGTRI T L H LKE DQMEYLEPRR L KELIK K H S EF I GYD IEL mvekttekevtdedeedtkkadedgee PK vee 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 216 - EHHG E D K D K PE ------ T P E W E TV N RASA LWTR PRTEIKD EEY QEL YK H I AH D H E N P V A WS H NK VEG K L DYT S LLY VP G 288
Cdd:PTZ00272 238 v KEGD E G K K K KT kkvkev T K E Y E VQ N KHKP LWTR DPKDVTK EEY AAF YK A I SN D W E D P A A TK H FS VEG Q L EFR S IMF VP K 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 289 RAPFD LYQRDAS R - GL KLYV Q RVFIMD QA E QFL P LY L R FVKG I VDS S DLPLN V SRE I LQ SGPVIDSMKSALT K RA L D M LE 367
Cdd:PTZ00272 318 RAPFD MFEPNKK R n NI KLYV R RVFIMD NC E DLC P DW L G FVKG V VDS E DLPLN I SRE N LQ QNKILKVIRKNIV K KC L E M FD 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 368 KL A KDE p E R YK SVWKN FG QVL K E G PA ED F ANR E K IAG LLRF A ST H SG da E HSVA L A DYV A RMK D GQ DKL YY LS G E S YAQI 447
Cdd:PTZ00272 398 EV A ENK - E D YK QFYEQ FG KNI K L G IH ED T ANR K K LME LLRF Y ST E SG -- E EMTT L K DYV T RMK A GQ KSI YY IT G D S KKKL 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 448 KD SP HL E VF R KK G I EVL LL T DR IDE WL M SYLTE F DG K S F VDVARGDLDLG kl D S D EEKQ AM EE AAK A KRG L VERIQQA LG 527
Cdd:PTZ00272 475 ET SP FI E QA R RR G L EVL FM T EP IDE YV M QQVKD F ED K K F ACLTKEGVHFE -- E S E EEKQ QR EE EKA A CEK L CKTMKEV LG 552
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 528 ED V SE V R VS H RL TD SP A IL AIGQGDLGLQ M R QI L ------ EA S GQKLPE SK PVF E F NP A HP L I EK L ---- D A EADGERFG 597
Cdd:PTZ00272 553 DK V EK V I VS E RL ST SP C IL VTSEFGWSAH M E QI M rnqalr DS S MAQYMM SK KTM E L NP R HP I I KE L rrrv G A DENDKAVK 632
650 660 670
....*....|....*....|....*....|..
gi 1893323920 598 DL ARV LFD QAA L AA G DS L K DP AA Y VR R L N KLL 629
Cdd:PTZ00272 633 DL VFL LFD TSL L TS G FQ L E DP TG Y AE R I N RMI 664
HSP90
pfam00183 Hsp90 protein;
195-629
8.03e-152
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 448.16
E-value: 8.03e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 195 K LRGI V R KYS DH I AL PI E L ---------------------------- PK - E HHG E DKD K PE T ------- P EWE TV N RASA 238
Cdd:pfam00183 7 K IKEL V K KYS EF I NF PI Y L wvekeeevevpdeeeeeeeeeeeeeddd PK v E EED E EEE K KK T kkvketv W EWE LL N KTKP 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 239 L WTR PRT E IKD EEY Q E L YK HIAH D H E N P V A WS H NK VEG KLDYT SLL YV P G RAPFDL YQRDA - SRGL KLYV Q RVFI M D QA E 317
Cdd:pfam00183 87 I WTR NPK E VTE EEY A E F YK SLSK D W E D P L A VK H FS VEG EVEFK SLL FI P K RAPFDL FENKK k KNNI KLYV R RVFI T D DF E 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 318 QFL P L YL R FVKG I VDS S DLPLNVSRE I LQ SGPVIDSM K SA L TKR ALDM LEKL A KDE p E R YK SV WK N FG QV LK E G PA ED FA 397
Cdd:pfam00183 167 DLI P E YL N FVKG V VDS D DLPLNVSRE T LQ QNKILKVI K KK L VRK ALDM FKEI A EEK - E D YK KF WK E FG KN LK L G II ED SS 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 398 NR E K I A G LLRF A S TH SGD ae HSVA L A DYV A RMK D GQ DKL YY LS GES YAQIKD SP H LE VFR KKG I EVL L LTD R IDE WLMSY 477
Cdd:pfam00183 246 NR N K L A K LLRF Y S SK SGD -- ELTS L D DYV S RMK E GQ KHI YY IT GES KEEVEN SP F LE RLK KKG Y EVL Y LTD P IDE YAVQQ 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 478 L T EFDGK SF V D VA RGD L D L G kl DSD EEK QAM EE AA K AKRG L VERIQQA LG ED V SE V R VS H RL T DSP AI L AIG Q GDLGLQ M 557
Cdd:pfam00183 324 L K EFDGK KL V N VA KEG L E L E -- EDE EEK KKD EE LK K EFEP L TKWLKDV LG DK V EK V V VS N RL V DSP CV L VTS Q YGWSAN M 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 558 RQ I LE A ------- S GQKLPE SK PVF E F NP A HP L I EK L ---- D A EA D GERFG DLA RV L FDQ A A L AA G D SL K DPA AYVR R LN 626
Cdd:pfam00183 402 ER I MK A qalrkds S MSSYMS SK KTL E I NP R HP I I KE L lkrv E A DK D DKTAK DLA LL L YET A L L RS G F SL E DPA SFAS R IY 481
...
gi 1893323920 627 KL L 629
Cdd:pfam00183 482 RM L 484
PTZ00130
PTZ00130 heat shock protein 90; Provisional
8-619
8.64e-127
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 393.64
E-value: 8.64e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 8 E TLGF QTEV KQ L LQLMIH SLY SN KE I FLRELISNA S DA AD K L RF EA L VKPEL L DGDAQ L R IRI GFD K DAGTVT I D D N GIG 87
Cdd:PTZ00130 66 E QHQY QTEV TR L MDIIVN SLY TQ KE V FLRELISNA A DA LE K I RF LS L SDESV L GEEKK L E IRI SAN K EKNILS I T D T GIG 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 88 M SR E EIVSH LGTIAKSGTS D FL KHL S g DQKK D SH LIGQFGVGFYSAF I VAD Q V D VY SRRAG lpa S E GVH W S S RGEGE F EV 167
Cdd:PTZ00130 146 M TK E DLINN LGTIAKSGTS N FL EAI S - KSGG D MS LIGQFGVGFYSAF L VAD K V I VY TKNNN --- D E QYI W E S TADAK F TI 221
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 168 ------ A T I dkp E RGTRI V L Q LKE SEDSFADGW KL RGIVR KYS DH I AL PI E L PK E H ----------------------- H 218
Cdd:PTZ00130 222 ykdprg S T L --- K RGTRI S L H LKE DATNLMNDK KL VDLIS KYS QF I QY PI Y L LH E N vyteevladiakemendpnydsv K 298
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 219 G E DK D K P --------- ETPE W ETV N RASAL W T RP RT E IK DE E Y QELYKHIAHDHEN P VAWS H NKV EG KLDYTS L L Y V P G R 289
Cdd:PTZ00130 299 V E ET D D P nkktrtvek KVKK W KLM N EQKPI W L RP PK E LT DE D Y KKFFSVLSGFNDE P LYHI H FFA EG EIEFKC L I Y I P S R 378
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 290 AP F --- D L YQRDA S rg L KLYV Q RV FIM D QAEQ FLP L Y LR FVKG I VDS S DLPLNVSRE I LQ SGPVIDSMKSALTKRA LD ML 366
Cdd:PTZ00130 379 AP S ind H L FTKQN S -- I KLYV R RV LVA D EFVE FLP R Y MS FVKG V VDS D DLPLNVSRE Q LQ QNKILKAVSKRIVRKI LD TF 456
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 367 EK L A K D ----------------------------- EP ER YK SVW K NFGQV LK E G PA ED FA NR E KI AG LL R F ASTHS gda E 417
Cdd:PTZ00130 457 RT L Y K E gkknketlraelaketdeekkkeiqkkin EP ST YK LIY K EYRKY LK T G CY ED DI NR N KI VK LL L F KTMLH --- P 533
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 418 H S VA L AD Y VAR MK DG Q DKL YY L SG E SY AQIKDS P H L EV F R KK G I E V LL LT DRI DE WLMSYLT E F DGK S F VDVAR G DLDLG 497
Cdd:PTZ00130 534 K S IS L DT Y IEN MK PD Q KFI YY A SG D SY EYLSKI P Q L QI F K KK N I D V VF LT ESV DE SCVQRVQ E Y DGK K F KSIQK G EITFE 613
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 498 K ld SDE EK QAM E EAA K AKRG L VER I QQA L GEDVSE V RV S H RL T D S P AILAIGQGD L GL QM R ----------- QI LEA SGQ 566
Cdd:PTZ00130 614 L -- TED EK KKE E KVK K MYKA L IDV I SDT L RNQIFK V EI S R RL V D A P CAVVSTEWG L SG QM E klmkinvnnsd QI KAM SGQ 691
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 1893323920 567 K lpeskp VF E F NP A HP - L I EK L DAEADGERFGD L A --- RVLFDQ A A LA A G DS L K D P A 619
Cdd:PTZ00130 692 K ------ IL E I NP D HP i M I DL L KRSVSNPKDSQ L T esi KIIYQS A K LA S G FD L E D T A 742
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
17-207
5.20e-98
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 297.51
E-value: 5.20e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 17 K QLL Q L M IHSLYSNKEIFLRELISNASDA A DKLR FEA L VK P E LLD G D AQ L R IRI GF DK DAG T V TI D D N GIGM SR EE IVSH 96
Cdd:cd16927 1 N QLL D L I IHSLYSNKEIFLRELISNASDA L DKLR YLS L TD P S LLD D D PE L E IRI SP DK ENR T L TI S D T GIGM TK EE LINN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 97 LGTIA K SGT SD FL KH L S g DQK KDS H LIGQFGVGFYSAF I VAD Q V D V YSRR AG lp AS EG VH W S S R G E G EFEVATIDK - PE R 175
Cdd:cd16927 81 LGTIA R SGT KA FL EA L Q - EGA KDS D LIGQFGVGFYSAF M VAD K V T V TTKS AG -- DD EG YR W E S D G G G SYTIEEAEG e LG R 157
170 180 190
....*....|....*....|....*....|..
gi 1893323920 176 GT R I V L Q LKE SEDS F ADGWKLRGI V R KYSD H I 207
Cdd:cd16927 158 GT K I T L H LKE DAKE F LEEARIKEL V K KYSD F I 189
PRK14083
PRK14083 HSP90 family protein; Provisional
12-632
1.16e-37
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 148.17
E-value: 1.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 12 FQ TEVKQLLQ L MIHS LYS NKEIFL REL IS NA S DA ADKL R fealvkpe L LD GD A QL RIRI - GF D KDA GT VTID DNGIG MSR 90
Cdd:PRK14083 5 FQ VDLRGVID L LSRH LYS SPRVYV REL LQ NA V DA ITAR R -------- A LD PT A PG RIRI e LT D AGG GT LIVE DNGIG LTE 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 91 EE IVSH L G TI AK S GTS D flk HLS G DQKK D sh LI GQFG V G FY S A F I VAD QVD V Y SR R A G lp ASEG V H W SSRGE G EFE V ATI 170
Cdd:PRK14083 77 EE VHEF L A TI GR S SKR D --- ENL G FARN D -- FL GQFG I G LL S C F L VAD EIV V V SR S A K -- DGPA V E W RGKAD G TYS V RKL 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 171 DKPER -- GT RIV L QLKESEDSFADGWKLRGIVR KY SDHIAL PI EL pkeh H GE D kdkpetpew ET VN RASAL WTR P r TEIK 248
Cdd:PRK14083 150 ETERA ep GT TVY L RPRPDAEEWLERETVEELAK KY GSLLPV PI RV ---- E GE K --------- GG VN ETPPP WTR D - YPDP 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 249 DEEYQE L YKHIAH ---------- DHEN P VA wshn KV EG kldyts LL YV - P GRAPF dlyqr D A S R GLKL Y VQ R VFIMDQ AE 317
Cdd:PRK14083 216 ETRREA L LAYGEE llgftpldvi PLDV P SG ---- GL EG ------ VA YV l P YAVSP ----- A A R R KHRV Y LK R MLLSEE AE 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 318 QF LP LYLR FV KGI V DSSD L PLNV SRE I L QSGPVIDSMKSA L TKRALDM L EK LA KDE PER Y ksvw KNFGQ V ---- L K EGPA 393
Cdd:PRK14083 281 NL LP DWAF FV RCV V NTDE L RPTA SRE A L YEDDALAAVREE L GEAIRKW L IG LA TTD PER L ---- RRLLA V hhlg V K ALAS 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 394 E D FANREK I AGL L R F AS T H s G D aehs VA LA DYVA R mkdg QDKLY Y L S G - ESYA Q IKD sphle VF R KK G IE V LLLTDRI D E 472
Cdd:PRK14083 357 H D DELLRL I LPW L P F ET T D - G R ---- MT LA EIRR R ---- HGVIR Y T S S v DEFR Q LAP ----- IA R AQ G MG V INGGYTY D S 422
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 473 W L MSY L TEF dgksfvdva R GD L DLGK LD SD E EKQAM E ---- E AAK A K R GLVERIQQA L GEDVSE V RVS H RLTDS - PA ILA 547
Cdd:PRK14083 423 E L LER L PRL --------- R PG L TVER LD PA E LTDRL E pltp E EEL A L R PFLAEAREV L APFGCD V VIR H FEPAD l PA LYL 493
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 548 IGQGDLGLQM R ------------ Q IL EASGQKL P ESKPVFEF N PAH PL IEK L DAEA D GERFGDLARV L FD QA A L AAGDS L 615
Cdd:PRK14083 494 HDRAAQHSRE R eeaveeaddlwa D IL GSLDESQ P APRARLVL N LRN PL VRR L ATLG D PKLLSRAVEA L YV QA L L LGHRP L 573
650
....*....|....*..
gi 1893323920 616 K dp A A YVRR LN KL LL E L 632
Cdd:PRK14083 574 R -- P A EMAL LN RS LL G L 588
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
30-184
3.67e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 60.36
E-value: 3.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 30 NKEIF LR ELI SN AS D A A D K LRF E alvkpelldg DAQLRIRIGF D K D AGTV T ID DNG I G MS r E E IVSHL gtiaksgtsd F L 109
Cdd:smart00387 1 GDPDR LR QVL SN LL D N A I K YTP E ---------- GGRITVTLER D G D HVEI T VE DNG P G IP - P E DLEKI ---------- F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1893323920 110 KHLSG D qk K D S HL IG QF G V G FYSAFIVADQV dvysrraglpasegvhwssrg E GE FE V at IDK P ER GT RIVLQ L K 184
Cdd:smart00387 60 PFFRT D -- K R S RK IG GT G L G LSIVKKLVELH --------------------- G GE IS V -- ESE P GG GT TFTIT L P 109
HATPase_TopVIB-like
cd16933 Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
7-185
4.23e-06
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain]
Cd Length: 203
Bit Score: 48.11
E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 7 KE T LGF QTEVKQ L LQL mihslysnkeif L REL IS N AS DA AD klrf EA LVK P ELL dgdaq LR I RIG f D KD AGT V TID DNG I 86
Cdd:cd16933 8 KE M LGF DNPIRS L YTT ------------ V REL VE N SL DA TE ---- EA GIL P DIK ----- VE I EEI - G KD HYK V IVE DNG P 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 87 G MSR E E I VSHL G TI aksgtsdflkh L S G DQKKDSHLI GQ F G V G ----- F YS AFIVADQ V DVY S RRAG lpa S EGVHW ---- 157
Cdd:cd16933 66 G IPE E Q I PKVF G KV ----------- L Y G SKYHNKQSR GQ Q G L G isaav L YS QMTTGKP V EII S STKD --- S NYAYV vklm 131
170 180 190
....*....|....*....|....*....|....
gi 1893323920 158 -- SSRG E G E F ---- EV ATID K P e R GTR IV L Q L KE 185
Cdd:cd16933 132 id TDKN E P E I leke EV ENRY K W - H GTR VE L E L EG 164
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
30-187
1.79e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 44.28
E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 30 NK E IF LR ELI SN AS D A A D K LRFE A lvkpelld G DAQLRIR igf DKDAG T V T ID DNGIG MS r E E IVSHL gtiaksgtsd F L 109
Cdd:pfam02518 1 GD E LR LR QVL SN LL D N A L K HAAK A -------- G EITVTLS --- EGGEL T L T VE DNGIG IP - P E DLPRI ---------- F E 58
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1893323920 110 KHLSG D QKK dshl I G QF G V G FYSAFIVADQVD vysrraglpasegvhwssrge G EFE V AT id K P ER GT RIV L Q L KESE 187
Cdd:pfam02518 59 PFSTA D KRG ---- G G GT G L G LSIVRKLVELLG --------------------- G TIT V ES -- E P GG GT TVT L T L PLAQ 109
PRK04184
PRK04184 DNA topoisomerase VI subunit B; Validated
4-93
8.18e-04
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain]
Cd Length: 535
Bit Score: 42.57
E-value: 8.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 4 E TQ KE T LGF QTEVKQ L LQL mihslysnkeif LR EL IS N AS DA AD klrf EA LVK P ELL dgdaq LR I - R IGFD KD AGT VT ID 82
Cdd:PRK04184 22 E KN KE L LGF DNPARA L YTT ------------ VK EL VD N SL DA CE ---- EA GIL P DIK ----- IE I k R VDEG KD HYR VT VE 80
90
....*....|.
gi 1893323920 83 DNG I G MSR EEI 93
Cdd:PRK04184 81 DNG P G IPP EEI 91
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
60-171
1.32e-03
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 39.24
E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 60 L D G DA Q l R I R I GFD K DA G TV T --- I D D N G I GMS R EE IVSH L G t I A K S GT sdflkhlsg DQ K KD S HLI G QF G V G F ysafiv 136
Cdd:pfam13589 13 I D A DA T - N I K I EVN K NR G GG T eiv I E D D G H GMS P EE LINA L R - L A T S AK --------- EA K RG S TDL G RY G I G L ------ 75
90 100 110
....*....|....*....|....*....|....*
gi 1893323920 137 adqvdvys RR A G L PASEGVHWS S RG EG EFEVA T I D 171
Cdd:pfam13589 76 -------- KL A S L SLGAKLTVT S KK EG KSSTL T L D 102
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
37-132
1.35e-03
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 38.93
E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893323920 37 EL IS NA S DA - A DK L RFEALVKPE L ldgdaqlririgfd KDAGTVTID D N G I GM SR EE i VS H LGTIAK S gtsdflkhlsg D 115
Cdd:cd16931 18 EL VD NA R DA d A TR L DIFIDDINL L -------------- RGGFMLSFL D D G N GM TP EE - AH H MISFGF S ----------- D 71
90
....*....|....*...
gi 1893323920 116 QKK D S H L - IG QF G V GF Y S 132
Cdd:cd16931 72 KRS D D H D h IG RY G N GF K S 89
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
