|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
477-766 |
1.87e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 92.30 E-value: 1.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 477 NALDLSLNSIFFIGVNQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNRldfdddaAFSELPLLEVLDLSY 556
Cdd:COG4886 50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 557 NAhyfriagVTHRLGFIEHLTNLRVLNLSNNDIFTLTETqlksaslgelvfsgnrldllwnaqdvrywqiFQNLTNLTRL 636
Cdd:COG4886 123 NQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEP-------------------------------LGNLTNLKSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 637 DLARNNLRHISSqAFLNLPRtLTDLYINDNMLNFFNWSLLEyFPHLRLLDLSGNQLFFLTNSLSTFaSSLETLLLSRNRI 716
Cdd:COG4886 165 DLSNNQLTDLPE-ELGNLTN-LKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1875036304 717 SHLPSdfLSGASSLIHLDLNSNQLKMLNrstfETKTATKLTVLELGGNPF 766
Cdd:COG4886 241 TDLPE--LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
70-534 |
2.47e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.92 E-value: 2.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 70 NFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESLKKLSLIQ 149
Cdd:COG4886 2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 150 NNIITLTKKNTSGLGNLESLYLGwncyfacdkkftiENGAFQNLTKLKVLSLSFNPLHSVPPSLPS--SLTELYLSNTHI 227
Cdd:COG4886 82 LSLLLLGLTDLGDLTNLTELDLS-------------GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 228 GNVSEEdFKELSNLRVLDLSGNcprcfnapfpcvpcqgdaSIQIHPLAFQTLTQLRYLNLSSTSLRKVPASwFDNMHNLK 307
Cdd:COG4886 149 TDLPEP-LGNLTNLKSLDLSNN------------------QLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 308 VLDLEFNYLMDEiasGEFLTKLPSLEILDLSYNyELKKYPqyiniskNFSKLISLQILHLRGyvfqeLRMEDFEPLRHLS 387
Cdd:COG4886 209 ELDLSGNQLTDL---PEPLANLTNLETLDLSNN-QLTDLP-------ELGNLTNLEELDLSN-----NQLTDLPPLANLT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 388 NLTTINLGVNFIKQIDFSIFQWFPNLKIIYLSENRISPLVSDTEQHDANGTSFQSHILKRRSADIQFDPHSNFYhntrpL 467
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----L 347
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036304 468 IKTECSRLGNALDLSLNSIFFIGVNQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNR 534
Cdd:COG4886 348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
872-1008 |
6.79e-14 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 69.66 E-value: 6.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 872 YDAYISYdtkdaSVTDWVINELRFHLEESEDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTA 951
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 952 FYLALQRLMEENMDVIVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQ 1008
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWK 131
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-587 |
1.05e-13 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 75.65 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 62 VTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSgnpavkkamtITDGAFLNLKHLRELLLEDNQLQ-QIPAGLPE 140
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP----------IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 141 SLKKLSLiQNNIITLTKKNTSGL-GNLESLYLGWNCYFACDKkftienGAFQNLTKLKVLSLSFNPL-HSVPPSLPS--S 216
Cdd:PLN00113 141 NLETLDL-SNNMLSGEIPNDIGSfSSLKVLDLGGNVLVGKIP------NSLTNLTSLEFLTLASNQLvGQIPRELGQmkS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 217 LTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNcprcfnapfpcvpcqgDASIQIhPLAFQTLTQLRYLNLSSTSLR-KV 295
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN----------------NLTGPI-PSSLGNLKNLQYLFLYQNKLSgPI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 296 PASWFdNMHNLKVLDLEFNYLMDEIAsgEFLTKLPSLEILDLSYNYELKKYPQYInisknfSKLISLQILHLRGyvfQEL 375
Cdd:PLN00113 277 PPSIF-SLQKLISLDLSDNSLSGEIP--ELVIQLQNLEILHLFSNNFTGKIPVAL------TSLPRLQVLQLWS---NKF 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 376 RMEDFEPLRHLSNLTTINLGVN---------------FIKQIDF--SIFQWFP-------NLKIIYLSENRIS------- 424
Cdd:PLN00113 345 SGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnLFKLILFsnSLEGEIPkslgacrSLRRVRLQDNSFSgelpsef 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 425 ---PLVSDTeqhDANGTSFQSHILKRR----SADIQFDPHSNFYHNTRPLIKTEcsRLGNaLDLSLNSIFFIGVNQFKDF 497
Cdd:PLN00113 425 tklPLVYFL---DISNNNLQGRINSRKwdmpSLQMLSLARNKFFGGLPDSFGSK--RLEN-LDLSRNQFSGAVPRKLGSL 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 498 GNISCLNLSSNGNGQVLNgTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGFIEHL 576
Cdd:PLN00113 499 SELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSGeIPKNLGNVESL 573
|
570
....*....|.
gi 1875036304 577 TNlrvLNLSNN 587
Cdd:PLN00113 574 VQ---VNISHN 581
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
627-766 |
1.75e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.11 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 627 FQNLTNLTRLDLARNNLRHISSqaFLNLPRtLTDLYINDNMLNFFnwSLLEYFPHLRLLDLS------GNQLFFLTNSLS 700
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIEnqrlppGEKLTFDPRSLA 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1875036304 701 TFASSLETLLLSRNRISHLpsDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPF 766
Cdd:cd21340 117 ALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
268-740 |
2.53e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.87 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 268 SIQIHPLAFQtLTQLRYLNLSSTSLR-KVPASWFDNMHNLKVLDLEFNYLMDEIASGEfltkLPSLEILDLSYNYELKKY 346
Cdd:PLN00113 82 SGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS----IPNLETLDLSNNMLSGEI 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 347 PQYINIsknFSkliSLQILHLRGYVfqeLRMEDFEPLRHLSNLTTINLGVN-FIKQIDFSIFQwFPNLKIIYLSENRISP 425
Cdd:PLN00113 157 PNDIGS---FS---SLKVLDLGGNV---LVGKIPNSLTNLTSLEFLTLASNqLVGQIPRELGQ-MKSLKWIYLGYNNLSG 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 426 LVSdteqHDANGTSFQSHIlkrrsaDIqfdphsnFYHNtrpLIKTECSRLGNALDLSLnsiFFIGVNQFKD------FG- 498
Cdd:PLN00113 227 EIP----YEIGGLTSLNHL------DL-------VYNN---LTGPIPSSLGNLKNLQY---LFLYQNKLSGpippsiFSl 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 499 -NISCLNLSSNG-NGQVlngTEFSC-LSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGfiE 574
Cdd:PLN00113 284 qKLISLDLSDNSlSGEI---PELVIqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN----KFSGeIPKNLG--K 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 575 HlTNLRVLNLSNNDIF-TLTETQLKSASLGELVFSGNRLDllwnaqdvryWQIFQNLT---NLTRLDLARNNLRHISSQA 650
Cdd:PLN00113 355 H-NNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLGacrSLRRVRLQDNSFSGELPSE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 651 FLNLPrTLTDLYINDNML----NFFNWSLleyfPHLRLLDLSGNQlFFLTNSLSTFASSLETLLLSRNRISH-LPSDF-- 723
Cdd:PLN00113 424 FTKLP-LVYFLDISNNNLqgriNSRKWDM----PSLQMLSLARNK-FFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLgs 497
|
490 500 510
....*....|....*....|....*....|....*...
gi 1875036304 724 ---------------------LSGASSLIHLDLNSNQL 740
Cdd:PLN00113 498 lselmqlklsenklsgeipdeLSSCKKLVSLDLSHNQL 535
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
631-692 |
2.53e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.53e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1875036304 631 TNLTRLDLARNNLRHISSQAFLNLPRtLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQL 692
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
872-1017 |
2.76e-09 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 57.37 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 872 YDAYISYDTKDasVTDWVINELRFHLEEsedKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKN-WN--- 947
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 948 FKTAFYLALQRlmeeNMDVI--------------------VFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFW 1007
Cdd:pfam01582 76 LVKILECALDL----GQKVIpifyevdpsdvrkqtgsfgkAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFW 151
|
170
....*....|
gi 1875036304 1008 QSLKNVVLTA 1017
Cdd:pfam01582 152 KKIAYDISNK 161
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
57-341 |
1.59e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 57.37 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 57 TVDKDVTEVDLSDNF---ITRVTNESFQGLQN---LTKINLNHNAKSQSGNPAVKKAMTITdgaFLNLKHLRELLLEDNQ 130
Cdd:cd00116 48 RPQPSLKELCLSLNEtgrIPRGLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLLRSS---SLQELKLNNNGLGDRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 131 LQQIPAGL---PESLKKLSLIQNNIitltkkntsGLGNLESLylgwncyfacdkkftieNGAFQNLTKLKVLSLSFNPLH 207
Cdd:cd00116 125 LRLLAKGLkdlPPALEKLVLGRNRL---------EGASCEAL-----------------AKALRANRDLKELNLANNGIG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 208 svPPSLPSSLtelylsnthignvseEDFKELSNLRVLDLSGNcprcfnapfpCVPCQGDASIQIhplAFQTLTQLRYLNL 287
Cdd:cd00116 179 --DAGIRALA---------------EGLKANCNLEVLDLNNN----------GLTDEGASALAE---TLASLKSLEVLNL 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 288 SSTSLRKVPASWFDN-----MHNLKVLDLEFNYLMDE--IASGEFLTKLPSLEILDLSYNY 341
Cdd:cd00116 229 GDNNLTDAGAAALASallspNISLLTLSLSCNDITDDgaKDLAEVLAEKESLLELDLRGNK 289
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
62-131 |
1.31e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 1.31e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 62 VTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSqsgnpavkkamTITDGAFLNLKHLRELLLEDNQL 131
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
734-817 |
8.15e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 50.08 E-value: 8.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 734 DLNSNQLKMLNRSTFETKTatKLTVLELGGNPFDCTCDLGDFLEWMdRNLNVRVPRLTDVICASPGDQEGKSIVSLDLST 813
Cdd:TIGR00864 1 DISNNKISTIEEGICANLC--NLSEIDLSGNPFECDCGLARLPRWA-EEKGVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....
gi 1875036304 814 CVSD 817
Cdd:TIGR00864 78 SGCD 81
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
764-812 |
1.26e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 43.57 E-value: 1.26e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1875036304 764 NPFDCTCDLGDFLEWMdrNLNVRVPRLTDVICASPGDQEGKSIVSLDLS 812
Cdd:smart00082 1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
477-766 |
1.87e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 92.30 E-value: 1.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 477 NALDLSLNSIFFIGVNQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNRldfdddaAFSELPLLEVLDLSY 556
Cdd:COG4886 50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 557 NAhyfriagVTHRLGFIEHLTNLRVLNLSNNDIFTLTETqlksaslgelvfsgnrldllwnaqdvrywqiFQNLTNLTRL 636
Cdd:COG4886 123 NQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEP-------------------------------LGNLTNLKSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 637 DLARNNLRHISSqAFLNLPRtLTDLYINDNMLNFFNWSLLEyFPHLRLLDLSGNQLFFLTNSLSTFaSSLETLLLSRNRI 716
Cdd:COG4886 165 DLSNNQLTDLPE-ELGNLTN-LKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1875036304 717 SHLPSdfLSGASSLIHLDLNSNQLKMLNrstfETKTATKLTVLELGGNPF 766
Cdd:COG4886 241 TDLPE--LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
70-534 |
2.47e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.92 E-value: 2.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 70 NFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESLKKLSLIQ 149
Cdd:COG4886 2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 150 NNIITLTKKNTSGLGNLESLYLGwncyfacdkkftiENGAFQNLTKLKVLSLSFNPLHSVPPSLPS--SLTELYLSNTHI 227
Cdd:COG4886 82 LSLLLLGLTDLGDLTNLTELDLS-------------GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 228 GNVSEEdFKELSNLRVLDLSGNcprcfnapfpcvpcqgdaSIQIHPLAFQTLTQLRYLNLSSTSLRKVPASwFDNMHNLK 307
Cdd:COG4886 149 TDLPEP-LGNLTNLKSLDLSNN------------------QLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 308 VLDLEFNYLMDEiasGEFLTKLPSLEILDLSYNyELKKYPqyiniskNFSKLISLQILHLRGyvfqeLRMEDFEPLRHLS 387
Cdd:COG4886 209 ELDLSGNQLTDL---PEPLANLTNLETLDLSNN-QLTDLP-------ELGNLTNLEELDLSN-----NQLTDLPPLANLT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 388 NLTTINLGVNFIKQIDFSIFQWFPNLKIIYLSENRISPLVSDTEQHDANGTSFQSHILKRRSADIQFDPHSNFYhntrpL 467
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----L 347
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036304 468 IKTECSRLGNALDLSLNSIFFIGVNQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNR 534
Cdd:COG4886 348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
63-421 |
3.43e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.53 E-value: 3.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 63 TEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESL 142
Cdd:COG4886 13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 143 KKLSLIQNNIITLTKkNTSGLGNLESLYLGWNcyfacdkKFTIENGAFQNLTKLKVLSLSFNPLHSVPPSLPS--SLTEL 220
Cdd:COG4886 93 GDLTNLTELDLSGNE-ELSNLTNLESLDLSGN-------QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 221 YLSNTHIGNVSEEdFKELSNLRVLDLSGNcprcfnapfpcvpcqgdaSIQIHPLAFQTLTQLRYLNLSSTSLRKVPASwF 300
Cdd:COG4886 165 DLSNNQLTDLPEE-LGNLTNLKELDLSNN------------------QITDLPEPLGNLTNLEELDLSGNQLTDLPEP-L 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 301 DNMHNLKVLDLEFNylmdEIASGEFLTKLPSLEILDLSYNyelkkypQYINISKNfSKLISLQILHLRGYVFQELRMEDF 380
Cdd:COG4886 225 ANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-------QLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1875036304 381 EPLRHLSNLTTINLGVNFIKQIDFSIFQWFPNLKIIYLSEN 421
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
463-793 |
4.71e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 88.07 E-value: 4.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 463 NTRPLIKTECSRLGNALDLSLNSIFFIGVNQFKDFGNISCLNLSSNgngqvlngTEFSCLSGIKYLDLTNNRLDfDDDAA 542
Cdd:COG4886 61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLT-DLPEE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 543 FSELPLLEVLDLSYNahyfriaGVTHRLGFIEHLTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAqdvr 622
Cdd:COG4886 132 LANLTNLKELDLSNN-------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP---- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 623 ywqiFQNLTNLTRLDLARNNLRHISSqAFLNLPRtLTDLYINDNMLNFFNWslLEYFPHLRLLDLSGNQLFFLTNSLStf 702
Cdd:COG4886 201 ----LGNLTNLEELDLSGNQLTDLPE-PLANLTN-LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN-- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 703 ASSLETLLLSRNRISHLPSDFL---SGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPFDCTCDLGDFLEWM 779
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELellLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
|
330
....*....|....
gi 1875036304 780 DRNLNVRVPRLTDV 793
Cdd:COG4886 351 TLLLLLNLLSLLLT 364
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
124-553 |
4.66e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.36 E-value: 4.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 124 LLLEDNQLQQIPAGLPESLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWNCYFACDKKFTIENGAFQNLTKLKVLSLSF 203
Cdd:COG4886 2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 204 NPLHSVPPSLPSSLTELylsnTHIGNVSEEDFKELSNLRVLDLSGNcpRCFNAPFPCVPCQGDASIQIH-------PLAF 276
Cdd:COG4886 82 LSLLLLGLTDLGDLTNL----TELDLSGNEELSNLTNLESLDLSGN--QLTDLPEELANLTNLKELDLSnnqltdlPEPL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 277 QTLTQLRYLNLSSTSLRKVPASwFDNMHNLKVLDLEFNYLMDEiasGEFLTKLPSLEILDLSYNyelkkypQYINISKNF 356
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGN-------QLTDLPEPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 357 SKLISLQILHLRGyvfqeLRMEDFEPLRHLSNLTTINLGVNFIKQIDFSIFqwFPNLKIIYLSENRISPLVSDTEQHDAN 436
Cdd:COG4886 225 ANLTNLETLDLSN-----NQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 437 GTSFQSHILKRRSADIQFDPHSNFYHNTRPLIKTECSRLGNALDLSLNSIFFIGVNQFKDFGNISCLNLSSNGNGQVLNG 516
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
|
410 420 430
....*....|....*....|....*....|....*..
gi 1875036304 517 TEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLD 553
Cdd:COG4886 378 TLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
872-1008 |
6.79e-14 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 69.66 E-value: 6.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 872 YDAYISYdtkdaSVTDWVINELRFHLEESEDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTA 951
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 952 FYLALQRLMEENMDVIVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQ 1008
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWK 131
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-587 |
1.05e-13 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 75.65 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 62 VTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSgnpavkkamtITDGAFLNLKHLRELLLEDNQLQ-QIPAGLPE 140
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP----------IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 141 SLKKLSLiQNNIITLTKKNTSGL-GNLESLYLGWNCYFACDKkftienGAFQNLTKLKVLSLSFNPL-HSVPPSLPS--S 216
Cdd:PLN00113 141 NLETLDL-SNNMLSGEIPNDIGSfSSLKVLDLGGNVLVGKIP------NSLTNLTSLEFLTLASNQLvGQIPRELGQmkS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 217 LTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNcprcfnapfpcvpcqgDASIQIhPLAFQTLTQLRYLNLSSTSLR-KV 295
Cdd:PLN00113 214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN----------------NLTGPI-PSSLGNLKNLQYLFLYQNKLSgPI 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 296 PASWFdNMHNLKVLDLEFNYLMDEIAsgEFLTKLPSLEILDLSYNYELKKYPQYInisknfSKLISLQILHLRGyvfQEL 375
Cdd:PLN00113 277 PPSIF-SLQKLISLDLSDNSLSGEIP--ELVIQLQNLEILHLFSNNFTGKIPVAL------TSLPRLQVLQLWS---NKF 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 376 RMEDFEPLRHLSNLTTINLGVN---------------FIKQIDF--SIFQWFP-------NLKIIYLSENRIS------- 424
Cdd:PLN00113 345 SGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnLFKLILFsnSLEGEIPkslgacrSLRRVRLQDNSFSgelpsef 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 425 ---PLVSDTeqhDANGTSFQSHILKRR----SADIQFDPHSNFYHNTRPLIKTEcsRLGNaLDLSLNSIFFIGVNQFKDF 497
Cdd:PLN00113 425 tklPLVYFL---DISNNNLQGRINSRKwdmpSLQMLSLARNKFFGGLPDSFGSK--RLEN-LDLSRNQFSGAVPRKLGSL 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 498 GNISCLNLSSNGNGQVLNgTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGFIEHL 576
Cdd:PLN00113 499 SELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSGeIPKNLGNVESL 573
|
570
....*....|.
gi 1875036304 577 TNlrvLNLSNN 587
Cdd:PLN00113 574 VQ---VNISHN 581
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
285-761 |
1.53e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.57 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 285 LNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEIASGEFLTKLPSLEILDLSYNYELKKYPQYINISKNFSKLISLQI 364
Cdd:COG4886 13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 365 LHLRGyvFQELRMEDFEPLRHLSNLTTINLGVNFIKQIDFSIFQwFPNLKIIYLSENRISPLVSDteqhdangtsfqshi 444
Cdd:COG4886 93 GDLTN--LTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP--------------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 445 lkrrsadiqfdphsnfyhntrpliktecsrlgnaldlslnsiffigvnqFKDFGNISCLNLSSNGNGQVlnGTEFSCLSG 524
Cdd:COG4886 155 -------------------------------------------------LGNLTNLKSLDLSNNQLTDL--PEELGNLTN 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 525 IKYLDLTNNRLDfDDDAAFSELPLLEVLDLSYNAhyfriagVTHRLGFIEHLTNLRVLNLSNNDIFTLTE-TQLKSasLG 603
Cdd:COG4886 184 LKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQ-------LTDLPEPLANLTNLETLDLSNNQLTDLPElGNLTN--LE 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 604 ELVFSGNRLDLLWNAQdvrywqifqNLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLYINDNMLNFFNWSLLEYFPHLR 683
Cdd:COG4886 254 ELDLSNNQLTDLPPLA---------NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036304 684 LLDLSGNQLFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLEL 761
Cdd:COG4886 325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
627-766 |
1.75e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.11 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 627 FQNLTNLTRLDLARNNLRHISSqaFLNLPRtLTDLYINDNMLNFFnwSLLEYFPHLRLLDLS------GNQLFFLTNSLS 700
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIEnqrlppGEKLTFDPRSLA 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1875036304 701 TFASSLETLLLSRNRISHLpsDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPF 766
Cdd:cd21340 117 ALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
183-692 |
2.15e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.87 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 183 FTIENGAFQNLTKLKVLSLSFNPLH-SVPPSLPSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNcprcfnapfpcv 261
Cdd:PLN00113 107 GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN------------ 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 262 pcqgdASIQIHPLAFQTLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEIASGefLTKLPSLEILDLSYNY 341
Cdd:PLN00113 175 -----VLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYNN 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 342 ELKKYPqyinisKNFSKLISLQILHLrgyvFQELRMEDFEP-LRHLSNLTTINLGVNFIK-QIDFSIFQwFPNLKIIYLS 419
Cdd:PLN00113 248 LTGPIP------SSLGNLKNLQYLFL----YQNKLSGPIPPsIFSLQKLISLDLSDNSLSgEIPELVIQ-LQNLEILHLF 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 420 ENRISPLVSDteqhdANGTSFQSHILK----RRSADIQFD--PHSNFyhntrpliktecsrlgNALDLSLNSIFFIGVNQ 493
Cdd:PLN00113 317 SNNFTGKIPV-----ALTSLPRLQVLQlwsnKFSGEIPKNlgKHNNL----------------TVLDLSTNNLTGEIPEG 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 494 FKDFGNISCLNLSSNG-NGQVlnGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNAHYFRIAGVTHrlgf 572
Cdd:PLN00113 376 LCSSGNLFKLILFSNSlEGEI--PKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKW---- 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 573 ieHLTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNaqdvrywQIFQNLTNLTRLDLARNNLR-HISSQaf 651
Cdd:PLN00113 450 --DMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVP-------RKLGSLSELMQLKLSENKLSgEIPDE-- 518
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1875036304 652 LNLPRTLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQL 692
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
268-740 |
2.53e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.87 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 268 SIQIHPLAFQtLTQLRYLNLSSTSLR-KVPASWFDNMHNLKVLDLEFNYLMDEIASGEfltkLPSLEILDLSYNYELKKY 346
Cdd:PLN00113 82 SGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS----IPNLETLDLSNNMLSGEI 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 347 PQYINIsknFSkliSLQILHLRGYVfqeLRMEDFEPLRHLSNLTTINLGVN-FIKQIDFSIFQwFPNLKIIYLSENRISP 425
Cdd:PLN00113 157 PNDIGS---FS---SLKVLDLGGNV---LVGKIPNSLTNLTSLEFLTLASNqLVGQIPRELGQ-MKSLKWIYLGYNNLSG 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 426 LVSdteqHDANGTSFQSHIlkrrsaDIqfdphsnFYHNtrpLIKTECSRLGNALDLSLnsiFFIGVNQFKD------FG- 498
Cdd:PLN00113 227 EIP----YEIGGLTSLNHL------DL-------VYNN---LTGPIPSSLGNLKNLQY---LFLYQNKLSGpippsiFSl 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 499 -NISCLNLSSNG-NGQVlngTEFSC-LSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGfiE 574
Cdd:PLN00113 284 qKLISLDLSDNSlSGEI---PELVIqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN----KFSGeIPKNLG--K 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 575 HlTNLRVLNLSNNDIF-TLTETQLKSASLGELVFSGNRLDllwnaqdvryWQIFQNLT---NLTRLDLARNNLRHISSQA 650
Cdd:PLN00113 355 H-NNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLGacrSLRRVRLQDNSFSGELPSE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 651 FLNLPrTLTDLYINDNML----NFFNWSLleyfPHLRLLDLSGNQlFFLTNSLSTFASSLETLLLSRNRISH-LPSDF-- 723
Cdd:PLN00113 424 FTKLP-LVYFLDISNNNLqgriNSRKWDM----PSLQMLSLARNK-FFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLgs 497
|
490 500 510
....*....|....*....|....*....|....*...
gi 1875036304 724 ---------------------LSGASSLIHLDLNSNQL 740
Cdd:PLN00113 498 lselmqlklsenklsgeipdeLSSCKKLVSLDLSHNQL 535
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
184-666 |
3.22e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 63.41 E-value: 3.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 184 TIENGAFQNLTKLKVLSLSFNPLHSVPPSLPSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNCPRCFNAPFPCVPC 263
Cdd:COG4886 16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 264 QGDASIQI-HPLAFQTLTQLRYLNLSSTSLRKVPASwFDNMHNLKVLDLEFNYLMDEiasGEFLTKLPSLEILDLSYNye 342
Cdd:COG4886 96 TNLTELDLsGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNN-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 343 lkkypQYINISKNFSKLISLQILHLRGYVFQELRmedfEPLRHLSNLTTINLGVNFIKQIDFSIFQwFPNLKIIYLSENR 422
Cdd:COG4886 170 -----QLTDLPEELGNLTNLKELDLSNNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 423 ISPLVSdteqhdangtsfqshilkrrsadiqfdphsnfyhntrpliktecsrlgnaldlslnsiffigvnqFKDFGNISC 502
Cdd:COG4886 240 LTDLPE-----------------------------------------------------------------LGNLTNLEE 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 503 LNLSSNgngQVLNGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNAhYFRIAGVTHRLGFIEHLTNLRVL 582
Cdd:COG4886 255 LDLSNN---QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL-LNLLELLILLLLLTTLLLLLLLL 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 583 NLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLY 662
Cdd:COG4886 331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
|
....
gi 1875036304 663 INDN 666
Cdd:COG4886 411 VNTE 414
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
278-717 |
7.40e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 62.26 E-value: 7.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 278 TLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNylmdeiasgEFLTKLPSLEILDLSYNyelkkypQYINISKNFS 357
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGN-------QLTDLPEELA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 358 KLISLQILHLRGYVFQELRmedfEPLRHLSNLTTINLGVNFIKQIDFSIFQwFPNLKIIYLSENRISPLvsdteqhdang 437
Cdd:COG4886 134 NLTNLKELDLSNNQLTDLP----EPLGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDL----------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 438 tsfqshilkrrsadiqfdphsnfyhntrPLIKTECSRLgNALDLSLNSIFFIGvnqfkdfgnisclnlssngngqvlngT 517
Cdd:COG4886 198 ----------------------------PEPLGNLTNL-EELDLSGNQLTDLP--------------------------E 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 518 EFSCLSGIKYLDLTNNRLDfdDDAAFSELPLLEVLDLSYNahyfRIAGvthrLGFIEHLTNLRVLNLSNNDIFTLTETQL 597
Cdd:COG4886 223 PLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNN----QLTD----LPPLANLTNLKTLDLSNNQLTDLKLKEL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 598 KSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLYINDNMLNFFNWSLLE 677
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1875036304 678 YFPHLRLLDLSGNQLFFLTNSLSTFASSLETLLLSRNRIS 717
Cdd:COG4886 373 GLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
631-692 |
2.53e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.53e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1875036304 631 TNLTRLDLARNNLRHISSQAFLNLPRtLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQL 692
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
872-1017 |
2.76e-09 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 57.37 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 872 YDAYISYDTKDasVTDWVINELRFHLEEsedKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKN-WN--- 947
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 948 FKTAFYLALQRlmeeNMDVI--------------------VFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFW 1007
Cdd:pfam01582 76 LVKILECALDL----GQKVIpifyevdpsdvrkqtgsfgkAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFW 151
|
170
....*....|
gi 1875036304 1008 QSLKNVVLTA 1017
Cdd:pfam01582 152 KKIAYDISNK 161
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
47-232 |
3.56e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 60.87 E-value: 3.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 47 NGRRLQEVPQTVDKDVTEVDLSDNFITRVTNESFQGLQNLtkiNLNHNAKSQSGNpavkkamTITDGaflnlkhLRELLL 126
Cdd:PRK15370 228 NSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL---DLFHNKISCLPE-------NLPEE-------LRYLSV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 127 EDNQLQQIPAGLPESLKKLSlIQNNIITLTKKNTSGlgNLESLYLGWNCYFACDKKFTIEngafqnltkLKVLSLSFNPL 206
Cdd:PRK15370 291 YDNSIRTLPAHLPSGITHLN-VQSNSLTALPETLPP--GLKTLEAGENALTSLPASLPPE---------LQVLDVSKNQI 358
|
170 180
....*....|....*....|....*.
gi 1875036304 207 HSVPPSLPSSLTELYLSNTHIGNVSE 232
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNALTNLPE 384
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
215-740 |
1.35e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.09 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 215 SSLTELYLSNTHI-GNVSEEDFKeLSNLRVLDLSGNcprcfnapfpcvpcqgDASIQIHPLAFQTLTQLRYLNLSSTSLR 293
Cdd:PLN00113 69 SRVVSIDLSGKNIsGKISSAIFR-LPYIQTINLSNN----------------QLSGPIPDDIFTTSSSLRYLNLSNNNFT 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 294 KVPASWFdnMHNLKVLDLEFNYLMDEIAS--GEFltklPSLEILDLSYNYELKKYPQYInisknfSKLISLQILHLRgyv 371
Cdd:PLN00113 132 GSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSL------TNLTSLEFLTLA--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 372 fqelrmedfeplrhlSNlttinlgvNFIKQIDFSIFQwFPNLKIIYLSENRISPLVSdteqHDANGTSFQSHIlkrrsaD 451
Cdd:PLN00113 197 ---------------SN--------QLVGQIPRELGQ-MKSLKWIYLGYNNLSGEIP----YEIGGLTSLNHL------D 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 452 IqfdphsnFYHNtrpLIKTECSRLGNALDLSLnsiFFIGVNQFKD------FG--NISCLNLSSNG-NGQVlngTEFSC- 521
Cdd:PLN00113 243 L-------VYNN---LTGPIPSSLGNLKNLQY---LFLYQNKLSGpippsiFSlqKLISLDLSDNSlSGEI---PELVIq 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 522 LSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGfiEHlTNLRVLNLSNNDIF-TLTETQLKS 599
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN----KFSGeIPKNLG--KH-NNLTVLDLSTNNLTgEIPEGLCSS 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 600 ASLGELVFSGNRLDllwnaqdvryWQIFQNLT---NLTRLDLARNNLRHISSQAFLNLPrTLTDLYINDNML----NFFN 672
Cdd:PLN00113 380 GNLFKLILFSNSLE----------GEIPKSLGacrSLRRVRLQDNSFSGELPSEFTKLP-LVYFLDISNNNLqgriNSRK 448
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036304 673 WSLleyfPHLRLLDLSGNQlFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQL 740
Cdd:PLN00113 449 WDM----PSLQMLSLARNK-FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
57-341 |
1.59e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 57.37 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 57 TVDKDVTEVDLSDNF---ITRVTNESFQGLQN---LTKINLNHNAKSQSGNPAVKKAMTITdgaFLNLKHLRELLLEDNQ 130
Cdd:cd00116 48 RPQPSLKELCLSLNEtgrIPRGLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLLRSS---SLQELKLNNNGLGDRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 131 LQQIPAGL---PESLKKLSLIQNNIitltkkntsGLGNLESLylgwncyfacdkkftieNGAFQNLTKLKVLSLSFNPLH 207
Cdd:cd00116 125 LRLLAKGLkdlPPALEKLVLGRNRL---------EGASCEAL-----------------AKALRANRDLKELNLANNGIG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 208 svPPSLPSSLtelylsnthignvseEDFKELSNLRVLDLSGNcprcfnapfpCVPCQGDASIQIhplAFQTLTQLRYLNL 287
Cdd:cd00116 179 --DAGIRALA---------------EGLKANCNLEVLDLNNN----------GLTDEGASALAE---TLASLKSLEVLNL 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 288 SSTSLRKVPASWFDN-----MHNLKVLDLEFNYLMDE--IASGEFLTKLPSLEILDLSYNY 341
Cdd:cd00116 229 GDNNLTDAGAAALASallspNISLLTLSLSCNDITDDgaKDLAEVLAEKESLLELDLRGNK 289
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
119-310 |
2.62e-08 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 55.56 E-value: 2.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 119 KHLRELLLEDNQLQQIPaGLpESLKKL-SL-IQNNIITlTKKNTSGLGNLESLYLGWNCYFacdkkfTIENgaFQNLTKL 196
Cdd:cd21340 24 KNLKVLYLYDNKITKIE-NL-EFLTNLtHLyLQNNQIE-KIENLENLVNLKKLYLGGNRIS------VVEG--LENLTNL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 197 KVL-----------SLSFNPlHSVPpSLPSSLTELYLSNTHIGNVseEDFKELSNLRVLDLSGNCPRCFNAPFPcvpcqg 265
Cdd:cd21340 93 EELhienqrlppgeKLTFDP-RSLA-ALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLD------ 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1875036304 266 dasiqihplAFQTLTQLRYLNLSSTSLRKVPaSWFDNM----HNLKVLD 310
Cdd:cd21340 163 ---------LLSSWPSLRELDLTGNPVCKKP-KYRDKIilasKSLEVLD 201
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
875-986 |
2.64e-08 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 53.09 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 875 YISYDTKDASVTDWVINELrfhleesEDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTAFYL 954
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 1875036304 955 ALQRLMEENmdVIVFILLE-----PVLQHSQYLRLRQ 986
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
117-348 |
4.52e-08 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 57.40 E-value: 4.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 117 NLK-HLRELLLEDNQLQQIPAGLPESLKKLSLIQNNIITLTKKNTSGlgnLESLYLGWNCYFACDKKFTIEngafqnltk 195
Cdd:PRK15370 217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSA---LQSLDLFHNKISCLPENLPEE--------- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 196 LKVLSLSFNPLHSVPPSLPSSLTELYLSNTHIGNVSEedfKELSNLRVLDLSGNCPRCFNAPFPcvpcqgdasiqihpla 275
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP---------------- 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1875036304 276 fqtlTQLRYLNLSSTSLRKVPASWfdnMHNLKVLDLEFNYLMDeiasgeFLTKLP-SLEILDLSYNyELKKYPQ 348
Cdd:PRK15370 346 ----PELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTN------LPENLPaALQIMQASRN-NLVRLPE 405
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
62-131 |
1.31e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 1.31e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 62 VTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSqsgnpavkkamTITDGAFLNLKHLRELLLEDNQL 131
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
120-340 |
1.82e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 52.87 E-value: 1.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 120 HLRellLEDNQLQQIPA-GLPESLKKLSLIQNNIITLtkKNTSGLGNLESLYLGWNCyfaCDKkftIENgaFQNLTKLKV 198
Cdd:cd21340 6 HLY---LNDKNITKIDNlSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQ---IEK---IEN--LENLVNLKK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 199 LSLSFNPLhSVPPSL--PSSLTELYLSNTHIGNVSEEDFKELS------NLRVLDLSGNcprcfnapfpcvpcqgdasiQ 270
Cdd:cd21340 73 LYLGGNRI-SVVEGLenLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGN--------------------N 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1875036304 271 IhplafQTLTQLRYLnlsstslrkvpaswfdnmHNLKVLDLEFNYL--MDEIAsgEFLTKLPSLEILDLSYN 340
Cdd:cd21340 132 I-----DSLEPLAPL------------------RNLEQLDASNNQIsdLEELL--DLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
280-340 |
1.84e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.84e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 280 TQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLmDEIASGEFlTKLPSLEILDLSYN 340
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAF-SGLPSLRYLDLSGN 59
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
547-766 |
6.85e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 52.36 E-value: 6.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 547 PLLEVLDLSYNAHYFRIAGVTHRLGFIEHLTNLRVLNLSNN----DIFTLTETQLKSASLGELvfsgnrlDLLWNAQDVR 622
Cdd:cd00116 51 PSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNalgpDGCGVLESLLRSSSLQEL-------KLNNNGLGDR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 623 YWQIFQ-----NLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLYINDNMLNFFNWSLLEY-------FPHLRLLDLSGN 690
Cdd:cd00116 124 GLRLLAkglkdLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRAlaeglkaNCNLEVLDLNNN 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 691 QL-----FFLTNSLSTFAsSLETLLLSRNRI-----SHLPSDFLSGASSLIHLDLNSNQL-----KMLNRSTFETKTatk 755
Cdd:cd00116 204 GLtdegaSALAETLASLK-SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDItddgaKDLAEVLAEKES--- 279
|
250
....*....|.
gi 1875036304 756 LTVLELGGNPF 766
Cdd:cd00116 280 LLELDLRGNKF 290
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
576-766 |
1.24e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 52.24 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 576 LTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQAFLNLP 655
Cdd:COG4886 9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 656 RTLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQLFFLTNSLSTFaSSLETLLLSRNRISHLPSDfLSGASSLIHLDL 735
Cdd:COG4886 89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEP-LGNLTNLKSLDL 166
|
170 180 190
....*....|....*....|....*....|.
gi 1875036304 736 NSNQLKMLNRstfETKTATKLTVLELGGNPF 766
Cdd:COG4886 167 SNNQLTDLPE---ELGNLTNLKELDLSNNQI 194
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
523-589 |
1.69e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 1.69e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1875036304 523 SGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfriagvthRLGFIE-----HLTNLRVLNLSNNDI 589
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-----------LLTTLSpgafsGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
579-746 |
3.29e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.24 E-value: 3.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 579 LRVLNLSNNDIFTLTEtQLKSAsLGELVFSGNRLDLLwnaqdvrywqiFQNLTN-LTRLDLARNNLRHISSqaflNLPRT 657
Cdd:PRK15370 243 IQEMELSINRITELPE-RLPSA-LQSLDLFHNKISCL-----------PENLPEeLRYLSVYDNSIRTLPA----HLPSG 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 658 LTDLYINDNMLNFFNWSL---LEYF---------------PHLRLLDLSGNQLFFLTNSLStfaSSLETLLLSRNRISHL 719
Cdd:PRK15370 306 ITHLNVQSNSLTALPETLppgLKTLeagenaltslpaslpPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNL 382
|
170 180
....*....|....*....|....*..
gi 1875036304 720 PSDFlsgASSLIHLDLNSNQLKMLNRS 746
Cdd:PRK15370 383 PENL---PAALQIMQASRNNLVRLPES 406
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
194-249 |
3.89e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 3.89e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1875036304 194 TKLKVLSLSFNPLHSVPPSL---PSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGN 249
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
680-740 |
3.97e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 3.97e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036304 680 PHLRLLDLSGNQLFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQL 740
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
216-424 |
5.99e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.63 E-value: 5.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 216 SLTELYLSNTHIgnVSEEDFKELSNLRVLDLSGNCPRcfnapfpcvpcqgdaSIQihplAFQTLTQLRYLNLSSTSLRKV 295
Cdd:cd21340 3 RITHLYLNDKNI--TKIDNLSLCKNLKVLYLYDNKIT---------------KIE----NLEFLTNLTHLYLQNNQIEKI 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 296 PAswFDNMHNLKVLDLEFNylmdEIASGEFLTKLPSLEILDLSY-----NYELKKYPQYIN-ISKnfskliSLQILHLRG 369
Cdd:cd21340 62 EN--LENLVNLKKLYLGGN----RISVVEGLENLTNLEELHIENqrlppGEKLTFDPRSLAaLSN------SLRVLNISG 129
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036304 370 yvfqeLRMEDFEPLRHLSNLTTINLGVNFI---KQIDFSIFQWfPNLKIIYLSENRIS 424
Cdd:cd21340 130 -----NNIDSLEPLAPLRNLEQLDASNNQIsdlEELLDLLSSW-PSLRELDLTGNPVC 181
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
734-817 |
8.15e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 50.08 E-value: 8.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 734 DLNSNQLKMLNRSTFETKTatKLTVLELGGNPFDCTCDLGDFLEWMdRNLNVRVPRLTDVICASPGDQEGKSIVSLDLST 813
Cdd:TIGR00864 1 DISNNKISTIEEGICANLC--NLSEIDLSGNPFECDCGLARLPRWA-EEKGVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....
gi 1875036304 814 CVSD 817
Cdd:TIGR00864 78 SGCD 81
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
215-292 |
8.20e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 8.20e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036304 215 SSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNCPRCfnapfpcvpcqgdasiqIHPLAFQTLTQLRYLNLSSTSL 292
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
764-812 |
1.26e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 43.57 E-value: 1.26e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1875036304 764 NPFDCTCDLGDFLEWMdrNLNVRVPRLTDVICASPGDQEGKSIVSLDLS 812
Cdd:smart00082 1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
239-316 |
1.33e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 1.33e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1875036304 239 SNLRVLDLSGNcprcfnapfpcvpcqgdaSIQ-IHPLAFQTLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYL 316
Cdd:pfam13855 1 PNLRSLDLSNN------------------RLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
503-557 |
1.33e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 1.33e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1875036304 503 LNLSSNgNGQVLNGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYN 557
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
519-666 |
1.70e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.09 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 519 FSCLSGIKYLDLTNNRLDFDDDaaFSELPLLEVLDLSYNahyfRIAgvthRLGFIEHLTNLRVLNLSNN----------D 588
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN----RIS----VVEGLENLTNLEELHIENQrlppgekltfD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 589 IFTLTETqlkSASLGELVFSGNRLDLLwnaqdvrywQIFQNLTNLTRLDLARNNLRHIS--SQAFLNLPRtLTDLYINDN 666
Cdd:cd21340 112 PRSLAAL---SNSLRVLNISGNNIDSL---------EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPS-LRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
704-766 |
1.75e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 1.75e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036304 704 SSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQLKMLNRSTFEtkTATKLTVLELGGNPF 766
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
479-535 |
8.92e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 8.92e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036304 479 LDLSLNSIFFIGVNQFKDFGNISCLNLSSNgNGQVLNGTEFSCLSGIKYLDLTNNRL 535
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
627-668 |
9.01e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 9.01e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1875036304 627 FQNLTNLTRLDLARNNLRHISSQAFLNLPRtLTDLYINDNML 668
Cdd:pfam13855 21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
467-692 |
9.81e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.81 E-value: 9.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 467 LIKTECSRLgnaLDLSLNSIFFIGVNQFKDFGNISCL-NLSSNGNGQVLNGTEFSC------LSGIKYLDLTNNRLDFD- 538
Cdd:cd00116 77 LTKGCGLQE---LDLSDNALGPDGCGVLESLLRSSSLqELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEGAs 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 539 -DDAA--FSELPLLEVLDLSYNAhyFRIAGVTHRLGFIEHLTNLRVLNLSNNdiftlTETQLKSASLGElvfsgnrldll 615
Cdd:cd00116 154 cEALAkaLRANRDLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNN-----GLTDEGASALAE----------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 616 wnaqdvrywqIFQNLTNLTRLDLARNNLR-----HISSqAFLNLPRTLTDLYINDNMLNFFNW-SLLEY---FPHLRLLD 686
Cdd:cd00116 216 ----------TLASLKSLEVLNLGDNNLTdagaaALAS-ALLSPNISLLTLSLSCNDITDDGAkDLAEVlaeKESLLELD 284
|
....*.
gi 1875036304 687 LSGNQL 692
Cdd:cd00116 285 LRGNKF 290
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
583-764 |
1.14e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.69 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 583 NLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLrhISSQAFLNLPRTLTDLY 662
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLL--LSSLLLLLSLLLLLLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 663 INDNMLNFFNWSLLEYFPHLRLLDLSGNQLFFltnslstFASSLETLLLSRNRISHLPsDFLSGASSLIHLDLNSNQLKM 742
Cdd:COG4886 79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD 150
|
170 180
....*....|....*....|..
gi 1875036304 743 LNRSTFEtktATKLTVLELGGN 764
Cdd:COG4886 151 LPEPLGN---LTNLKSLDLSNN 169
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
571-744 |
2.21e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.78 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 571 GFIEHL---TNLRVLNLSNNDI----FTLTETQLKS-ASLGELVFSGNRLDllwnAQDVRYW-QIFQNLTNLTRLDLARN 641
Cdd:COG5238 227 ILAEALkgnKSLTTLDLSNNQIgdegVIALAEALKNnTTVETLYLSGNQIG----AEGAIALaKALQGNTTLTSLDLSVN 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 642 NLRHISSQAF---LNLPRTLTDLYINDNMLNFFNWSLL----EYFPHLRLLDLSGNQL-----FFLTNSLSTfASSLETL 709
Cdd:COG5238 303 RIGDEGAIALaegLQGNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALAKYLEG-NTTLREL 381
|
170 180 190
....*....|....*....|....*....|....*
gi 1875036304 710 LLSRNRISHLpsdflsGASSLIHLdLNSNQLKMLN 744
Cdd:COG5238 382 NLGKNNIGKQ------GAEALIDA-LQTNRLHTLI 409
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
60-355 |
2.54e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.22 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 60 KDVTEVDLSDNFITRVTNESFQGLQNLTKINLNHNaksqsgnpavkKAMTITDGAFLNLKHLRELLLEDNQLQ-QIPAGL 138
Cdd:PLN00113 284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN-----------NFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNL 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 139 PE--SLKKLSLIQNNiitLTKKNTSGL---GNLESLYLGWNcyfACDKKFTIENGAFQNLTKLKVLSLSFNPlhsvppSL 213
Cdd:PLN00113 353 GKhnNLTVLDLSTNN---LTGEIPEGLcssGNLFKLILFSN---SLEGEIPKSLGACRSLRRVRLQDNSFSG------EL 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 214 PSSLTELYL-------SNTHIGNVSEEDFkELSNLRVLDLS-----GNCPRCFNAP-FPCVPCQGDASIQIHPLAFQTLT 280
Cdd:PLN00113 421 PSEFTKLPLvyfldisNNNLQGRINSRKW-DMPSLQMLSLArnkffGGLPDSFGSKrLENLDLSRNQFSGAVPRKLGSLS 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 281 QLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEIASGefLTKLPSLEILDLSYNYELKKYPQ---------YIN 351
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS--FSEMPVLSQLDLSQNQLSGEIPKnlgnveslvQVN 577
|
....
gi 1875036304 352 ISKN 355
Cdd:PLN00113 578 ISHN 581
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
212-355 |
2.99e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 212 SLPSSLTELYLSNTHIGNVSEEDF----KELSNLRVLDLSGNcprcfnapfpCVPCQGDASI--------QIHPL----- 274
Cdd:COG5238 205 TQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNN----------QIGDEGVIALaealknntTVETLylsgn 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 275 ------------AFQTLTQLRYLNLSSTSLR----KVPASWFDNMHNLKVLDLEFNYLMDE--IASGEFLTKLPSLEILD 336
Cdd:COG5238 275 qigaegaialakALQGNTTLTSLDLSVNRIGdegaIALAEGLQGNKTLHTLNLAYNGIGAQgaIALAKALQENTTLHSLD 354
|
170 180 190
....*....|....*....|....*....|..
gi 1875036304 337 LSYNY-------ELKKYPQ------YINISKN 355
Cdd:COG5238 355 LSDNQigdegaiALAKYLEgnttlrELNLGKN 386
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
592-766 |
3.26e-04 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 44.77 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 592 LTETQLKSASLGELVFSGNRLDLL--WNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQ--AFLNLPRTLTDLYINDNM 667
Cdd:PRK15387 294 LTSLPVLPPGLQELSVSDNQLASLpaLPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQlaSLPTLPSELYKLWAYNNR 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 668 LNffnwSLLEYFPHLRLLDLSGNQLffltNSLSTFASSLETLLLSRNRISHLPSDflsgASSLIHLDLNSNQLKMLNRST 747
Cdd:PRK15387 374 LT----SLPALPSGLKELIVSGNRL----TSLPVLPSELKELMVSGNRLTSLPML----PSGLLSLSVYRNQLTRLPESL 441
|
170
....*....|....*....
gi 1875036304 748 FETKTAtklTVLELGGNPF 766
Cdd:PRK15387 442 IHLSSE---TTVNLEGNPL 457
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
141-206 |
9.45e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 9.45e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1875036304 141 SLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWNCyfacdkKFTIENGAFQNLTKLKVLSLSFNPL 206
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL------LTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
513-610 |
1.12e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.70 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 513 VLNGTEfsCLSGIKYLDLTNNRLD------FDDDAAFSELPLLEVLDLSYNahyfRIAGvthrLGFIEHLTNLRVLNLSN 586
Cdd:cd21340 82 VVEGLE--NLTNLEELHIENQRLPpgekltFDPRSLAALSNSLRVLNISGN----NIDS----LEPLAPLRNLEQLDASN 151
|
90 100
....*....|....*....|....*..
gi 1875036304 587 NDIFTLTETQ--LKS-ASLGELVFSGN 610
Cdd:cd21340 152 NQISDLEELLdlLSSwPSLRELDLTGN 178
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
500-587 |
1.15e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 42.88 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 500 ISCLNLSSNG-NGQVlnGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNahyfRIAG-VTHRLGfieHLT 577
Cdd:PLN03150 420 IDGLGLDNQGlRGFI--PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYN----SFNGsIPESLG---QLT 490
|
90
....*....|
gi 1875036304 578 NLRVLNLSNN 587
Cdd:PLN03150 491 SLRILNLNGN 500
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
165-227 |
1.55e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 1.55e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1875036304 165 NLESLYLgwncyfACDKKFTIENGAFQNLTKLKVLSLSFNPLHSVPP---SLPSSLTELYLSNTHI 227
Cdd:pfam13855 2 NLRSLDL------SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
120-174 |
2.34e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 2.34e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036304 120 HLRELLLEDNQLQQIPAGL---PESLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWN 174
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
279-341 |
2.74e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 41.73 E-value: 2.74e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1875036304 279 LTQLRYLNLSSTSLR-KVPASwFDNMHNLKVLDLEFNYLMDEIAsgEFLTKLPSLEILDLSYNY 341
Cdd:PLN03150 441 LRHLQSINLSGNSIRgNIPPS-LGSITSLEVLDLSYNSFNGSIP--ESLGQLTSLRILNLNGNS 501
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
351-557 |
2.84e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 351 NISK--NFSKLISLQILHLrgyvfQELRMEDFEPLRHLSNLTTINLGVNFIKQIDFsiFQWFPNLKIIYLSENRISpLVS 428
Cdd:cd21340 13 NITKidNLSLCKNLKVLYL-----YDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 429 DTEqhdaNGTSFQS-HILKRRSAD---IQFDPHSNFYhntrpliktecsrLGNALdlslnsiffigvnqfkdfgniSCLN 504
Cdd:cd21340 85 GLE----NLTNLEElHIENQRLPPgekLTFDPRSLAA-------------LSNSL---------------------RVLN 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1875036304 505 LSSNgngQVLNGTEFSCLSGIKYLDLTNNRL-DFDD-DAAFSELPLLEVLDLSYN 557
Cdd:cd21340 127 ISGN---NIDSLEPLAPLRNLEQLDASNNQIsDLEElLDLLSSWPSLRELDLTGN 178
|
|
| LRR_12 |
pfam18837 |
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ... |
389-418 |
3.17e-03 |
|
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.
Pssm-ID: 408607 Cd Length: 30 Bit Score: 36.17 E-value: 3.17e-03
10 20 30
....*....|....*....|....*....|
gi 1875036304 389 LTTINLGVNFIKQIDFSIFQWFPNLKIIYL 418
Cdd:pfam18837 1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
307-612 |
3.78e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 307 KVLDLEFNYLMDEIASgEFLTKLPSLEILDLSYN----YELKKypqyinISKNFSKLISLQILHLRGYvfqELRMED--- 379
Cdd:cd00116 1 LQLSLKGELLKTERAT-ELLPKLLCLQVLRLEGNtlgeEAAKA------LASALRPQPSLKELCLSLN---ETGRIPrgl 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 380 ---FEPLRHLSNLTTINLGVNFIkQID----FSIFQWFPNLKIIYLSENRIS----PLVSDTEQHdaNGTSFQSHILKRR 448
Cdd:cd00116 71 qslLQGLTKGCGLQELDLSDNAL-GPDgcgvLESLLRSSSLQELKLNNNGLGdrglRLLAKGLKD--LPPALEKLVLGRN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 449 --SADIQFDPHSNFYHNTRplIKTecsrlgnaLDLSLNSIffigvnqfKDFGNIS-CLNLSSNgngqvlngtefsclSGI 525
Cdd:cd00116 148 rlEGASCEALAKALRANRD--LKE--------LNLANNGI--------GDAGIRAlAEGLKAN--------------CNL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036304 526 KYLDLTNNRLDFDDDAAFSE----LPLLEVLDLSYNAhyFRIAGVTHRL-GFIEHLTNLRVLNLSNNDI-----FTLTET 595
Cdd:cd00116 196 EVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNN--LTDAGAAALAsALLSPNISLLTLSLSCNDItddgaKDLAEV 273
|
330
....*....|....*..
gi 1875036304 596 QLKSASLGELVFSGNRL 612
Cdd:cd00116 274 LAEKESLLELDLRGNKF 290
|
|
| |
