NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1863504267|gb|QLA55128|]
View 

2Fe-2S iron-sulfur cluster binding domain-containing protein [Streptomyces violascens]

Protein Classification

(2Fe-2S)-binding protein( domain architecture ID 11449880)

(2Fe-2S)-binding protein is the small subunit of a dehydrogenase or oxidoreductase enzyme complex such as carbon monoxide dehydrogenase and isoquinoline 1-oxidoreductase; contains a a 2Fe-2S ferredoxin-type domain which binds 2Fe-2S clusters

Gene Ontology:  GO:0046872|GO:0051536|GO:0051537
PubMed:  11734195
SCOP:  3000113

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 12-177 3.51e-87

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 253.09  E-value: 3.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  12 ITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGDD 91
Cdd:COG2080     4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  92 LHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQA 171
Cdd:COG2080    84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDEN-----------------PNP-TEEEIREALSGNLCRCTGYVRIVRA 145


                  ....*.
gi 1863504267 172 VAHAAG 177
Cdd:COG2080   146 VKRAAA 151
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 12-177 3.51e-87

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 253.09  E-value: 3.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  12 ITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGDD 91
Cdd:COG2080     4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  92 LHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQA 171
Cdd:COG2080    84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDEN-----------------PNP-TEEEIREALSGNLCRCTGYVRIVRA 145


                  ....*.
gi 1863504267 172 VAHAAG 177
Cdd:COG2080   146 VKRAAA 151
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
 2-177 8.87e-84

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 246.61  E-value: 8.87e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   2 APEPSPTSSAITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVT 81
Cdd:PRK11433   42 AATPAPEISPVTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGAEIT 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  82 TVEGLADGDDLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHAAGWPSAVTPDVdpdATPAPLTPEEIRERLSGNLCR 161
Cdd:PRK11433  122 TIEGLGSPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEIKDGIPSHVTVDL---TAAPELTADEIRERMSGNICR 198

                         170
                  ....*....|....*.
gi 1863504267 162 CGAYVSIVQAVAHAAG 177
Cdd:PRK11433  199 CGAYSNILEAIEDVAG 214
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
11-176 7.22e-53

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 166.51  E-value: 7.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  11 AITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGD 90
Cdd:NF041020   10 KIRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSCTVLAVQADGAEITTIEGLSKDG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  91 DLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQ 170
Cdd:NF041020   90 KLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKEN-----------------PNP-TEEEIRDGIHGNLCRCTGYQNIVK 151


                  ....*.
gi 1863504267 171 AVAHAA 176
Cdd:NF041020  152 AVKEAS 157
pucE TIGR03198
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ...
 13-176 1.03e-42

xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.


Pssm-ID: 132242 [Multi-domain]  Cd Length: 151  Bit Score: 140.37  E-value: 1.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  13 TLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADgDDL 92
Cdd:TIGR03198   5 RFTVNGQAWEVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLIDGKLANACLTMAYQADGHEITTIEGIAE-NEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  93 HPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQAV 172
Cdd:TIGR03198  84 DPCQTAFLEEGGFQCGYCTPGMVVALKALFRET-----------------PQP-SDEDMEEGLSGNLCRCTGYGGIIRSA 145


                  ....
gi 1863504267 173 AHAA 176
Cdd:TIGR03198 146 CRIR 149
Fer2_2 pfam01799
[2Fe-2S] binding domain;
82-172 5.76e-35

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 117.92  E-value: 5.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  82 TVEGLADGDDlHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPLTPEEIRERLSGNLCR 161
Cdd:pfam01799   1 TIEGLAESGG-EPVQQAFAEAGAVQCGYCTPGMIMSAYALLERN-----------------PPPPTEAEIREALSGNLCR 62

                          90
                  ....*....|.
gi 1863504267 162 CGAYVSIVQAV 172
Cdd:pfam01799  63 CTGYRRIVDAV 73
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 12-79 1.55e-06

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 44.31  E-value: 1.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1863504267  12 ITLHINGEKHHLSVDHRTTLLDALRErLDLTgTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDRE 79
Cdd:cd00207     1 VTINVPGSGVEVEVPEGETLLDAARE-AGID-IPYSCRAGACGTCKVEVVEGEVDQSDPSLLDEEEAE 66
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 12-177 3.51e-87

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 253.09  E-value: 3.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  12 ITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGDD 91
Cdd:COG2080     4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  92 LHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQA 171
Cdd:COG2080    84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDEN-----------------PNP-TEEEIREALSGNLCRCTGYVRIVRA 145


                  ....*.
gi 1863504267 172 VAHAAG 177
Cdd:COG2080   146 VKRAAA 151
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
 2-177 8.87e-84

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 246.61  E-value: 8.87e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   2 APEPSPTSSAITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVT 81
Cdd:PRK11433   42 AATPAPEISPVTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGAEIT 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  82 TVEGLADGDDLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHAAGWPSAVTPDVdpdATPAPLTPEEIRERLSGNLCR 161
Cdd:PRK11433  122 TIEGLGSPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEIKDGIPSHVTVDL---TAAPELTADEIRERMSGNICR 198

                         170
                  ....*....|....*.
gi 1863504267 162 CGAYVSIVQAVAHAAG 177
Cdd:PRK11433  199 CGAYSNILEAIEDVAG 214
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
11-176 7.22e-53

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 166.51  E-value: 7.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  11 AITLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGD 90
Cdd:NF041020   10 KIRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSCTVLAVQADGAEITTIEGLSKDG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  91 DLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQ 170
Cdd:NF041020   90 KLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKEN-----------------PNP-TEEEIRDGIHGNLCRCTGYQNIVK 151


                  ....*.
gi 1863504267 171 AVAHAA 176
Cdd:NF041020  152 AVKEAS 157
XdhA COG4630
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ...
 12-191 2.30e-48

Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];


Pssm-ID: 443668 [Multi-domain]  Cd Length: 476  Bit Score: 163.38  E-value: 2.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  12 ITLHINGEKHHLS-VDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRR--------VVSCLTLAVTAQDREVTT 82
Cdd:COG4630     1 IRFLLNGELVELSdVPPTTTLLDWLREDRGLTGTKEGCAEGDCGACTVVVGELDdgglryraVNACILFLPQLDGKALVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  83 VEGLADGDD-LHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEhaagwpsavtpdvdpdatPAPLTPEEIRERLSGNLCR 161
Cdd:COG4630    81 VEGLAGPDGaLHPVQQAMVDHHGSQCGFCTPGFVMSLFALYER------------------GPAPDRADIEDALSGNLCR 142

                         170       180       190
                  ....*....|....*....|....*....|
gi 1863504267 162 CGAYVSIVQAvAHAAGTHGRNPALTTEEGA 191
Cdd:COG4630   143 CTGYRPIIDA-ARAMAEAPAPDPFAADRAA 171
pucE TIGR03198
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ...
 13-176 1.03e-42

xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.


Pssm-ID: 132242 [Multi-domain]  Cd Length: 151  Bit Score: 140.37  E-value: 1.03e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  13 TLHINGEKHHLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADgDDL 92
Cdd:TIGR03198   5 RFTVNGQAWEVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLIDGKLANACLTMAYQADGHEITTIEGIAE-NEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  93 HPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLCRCGAYVSIVQAV 172
Cdd:TIGR03198  84 DPCQTAFLEEGGFQCGYCTPGMVVALKALFRET-----------------PQP-SDEDMEEGLSGNLCRCTGYGGIIRSA 145


                  ....
gi 1863504267 173 AHAA 176
Cdd:TIGR03198 146 CRIR 149
PRK09908 PRK09908
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
3-172 4.37e-39

xanthine dehydrogenase iron sulfur-binding subunit XdhC;


Pssm-ID: 182139 [Multi-domain]  Cd Length: 159  Bit Score: 131.19  E-value: 4.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   3 PEPSPTSsAITLHINGEKHHLSVDHRTTLLDALRERlDLTGTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVTT 82
Cdd:PRK09908    1 MNHSETI-TIECTINGMPFQLHAAPGTPLSELLREQ-GLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  83 VEGLADGDDLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEhaagwpsavtpdvdpdATPAPLTPEEIRERLSGNLCRC 162
Cdd:PRK09908   79 LEGEAKGGKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAK----------------PREKPLTITEIRRGLAGNLCRC 142

                         170
                  ....*....|
gi 1863504267 163 GAYVSIVQAV 172
Cdd:PRK09908  143 TGYQMIVNTV 152
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
 12-189 9.52e-38

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 135.09  E-value: 9.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  12 ITLHINGEKHHLS-VDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDR---------RRVVSCLTLAVTAQDREVT 81
Cdd:TIGR02963   1 IRFFLNGETVTLSdVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVGElvdggklryRSVNACIQFLPSLDGKAVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  82 TVEGLADGD-DLHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSGNLC 160
Cdd:TIGR02963  81 TVEDLRQPDgRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNS-----------------PAP-SRADIEDALQGNLC 142

                         170       180
                  ....*....|....*....|....*....
gi 1863504267 161 RCGAYVSIVQAvAHAAGTHGRNPALTTEE 189
Cdd:TIGR02963 143 RCTGYRPILDA-AEAAFDYPCSDPLDADR 170
Fer2_2 pfam01799
[2Fe-2S] binding domain;
82-172 5.76e-35

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 117.92  E-value: 5.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  82 TVEGLADGDDlHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPLTPEEIRERLSGNLCR 161
Cdd:pfam01799   1 TIEGLAESGG-EPVQQAFAEAGAVQCGYCTPGMIMSAYALLERN-----------------PPPPTEAEIREALSGNLCR 62

                          90
                  ....*....|.
gi 1863504267 162 CGAYVSIVQAV 172
Cdd:pfam01799  63 CTGYRRIVDAV 73
PLN00192 PLN00192
aldehyde oxidase
 8-171 2.66e-32

aldehyde oxidase


Pssm-ID: 215096 [Multi-domain]  Cd Length: 1344  Bit Score: 122.13  E-value: 2.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267    8 TSSAITLHINGEKHHL-SVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVL----------VDRRRVVSCLTLAVTAQ 76
Cdd:PLN00192     2 SNMSLVFAVNGERFELsSVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVLlskydpvldqVEDFTVSSCLTLLCSVN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   77 DREVTTVEGLADGDD-LHPVQQAFLDLDGYQCGYCTPGqICSAI--ALIEEHAAGWPsavtpdvDPDATPAPLTPEEIRE 153
Cdd:PLN00192    82 GCSITTSEGLGNSKDgFHPIHKRFAGFHASQCGFCTPG-MCISLfsALVNADKTDRP-------EPPSGFSKLTVVEAEK 153

                          170
                   ....*....|....*...
gi 1863504267  154 RLSGNLCRCGAYVSIVQA 171
Cdd:PLN00192   154 AVSGNLCRCTGYRPIVDA 171
PLN02906 PLN02906
xanthine dehydrogenase
 30-171 2.19e-30

xanthine dehydrogenase


Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 116.72  E-value: 2.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   30 TLLDALRErLDLTGTKKGCDQGQCGACTVLV---DR-------RRVVSCLTLAVTAQDREVTTVEGLADGDD-LHPVQQA 98
Cdd:PLN02906     3 TLLEYLRD-LGLTGTKLGCGEGGCGACTVMVshyDRktgkcvhYAVNACLAPLYSVEGMHVITVEGIGNRRDgLHPVQEA 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1863504267   99 FLDLDGYQCGYCTPGQICSAIALIEehaagwpsavtpdvdpdATPAPLTPEEIRERLSGNLCRCGAYVSIVQA 171
Cdd:PLN02906    82 LASMHGSQCGFCTPGFIMSMYALLR-----------------SSKTPPTEEQIEECLAGNLCRCTGYRPILDA 137
mam_aldehyde_ox TIGR02969
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ...
 10-171 6.24e-30

aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.


Pssm-ID: 132014 [Multi-domain]  Cd Length: 1330  Bit Score: 115.49  E-value: 6.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   10 SAITLHINGEKH-HLSVDHRTTLLDALRERLDLTGTKKGCDQGQCGACTVLVDRRR----------VVSCLTLAVTAQDR 78
Cdd:TIGR02969    1 PELLFYVNGRKVvEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNpstksirhhpVNACLTPICSLYGA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267   79 EVTTVEGLADGDD-LHPVQQAFLDLDGYQCGYCTPGQICSAIALIEEHaagwpsavtpdvdpdatPAPlTPEEIRERLSG 157
Cdd:TIGR02969   81 AVTTVEGIGSTRTrLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNH-----------------PEP-TLDQLTDALGG 142

                          170
                   ....*....|....
gi 1863504267  158 NLCRCGAYVSIVQA 171
Cdd:TIGR02969  143 NLCRCTGYRPIIDA 156
PRK09800 PRK09800
putative hypoxanthine oxidase; Provisional
 51-188 2.32e-08

putative hypoxanthine oxidase; Provisional


Pssm-ID: 182084 [Multi-domain]  Cd Length: 956  Bit Score: 52.91  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  51 GQCGACTVLVDRRRVVSCLTLAVTAQDREVTTVEGLADGDDLHPVQQAFLDLDGYQCGYCTPgqicsAIALIeehaagwp 130
Cdd:PRK09800   42 GFAGSDAIIFNGNIVNASLLIAAQLEKADIRTAESLGKWNELSLVQQAMVDVGVVQSGYNDP-----AAALI-------- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1863504267 131 saVTPDVDPDATPaplTPEEIRERLSGNLCRCGAYVSIVQAVAHAAgTHGRNPALTTE 188
Cdd:PRK09800  109 --ITDLLDRIAAP---TREEIDDALSGLFSRDAGWQQYYQVIELAV-ARKNNPQATID 160
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 12-79 1.55e-06

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 44.31  E-value: 1.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1863504267  12 ITLHINGEKHHLSVDHRTTLLDALRErLDLTgTKKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDRE 79
Cdd:cd00207     1 VTINVPGSGVEVEVPEGETLLDAARE-AGID-IPYSCRAGACGTCKVEVVEGEVDQSDPSLLDEEEAE 66
PRK12576 PRK12576
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
19-173 2.67e-06

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 237143 [Multi-domain]  Cd Length: 279  Bit Score: 46.28  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  19 EKHHLSVDHRTTLLDALR---ERLDLTGT-KKGCDQGQCGACTVLVDRRRVVSCLTLA--VTAQDREVTTVEGLadgDDL 92
Cdd:PRK12576   25 QEYKVKVDRFTQVTEALRrikEEQDPTLSyRASCHMAVCGSCGMKINGEPRLACKTLVldVAKKYNSVITIEPM---DYF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1863504267  93 HPVQQAFLDLDGYQcgyctpgqicsaialiEEHAAGWPSAVTPD--VDPDATPaPLTPEEIRERLSGNLC-RCGAYVSIV 169
Cdd:PRK12576  102 KVVKDLIVDFDEFY----------------ERMFKVKPRLYRAKevLEGKAEH-RLKPEDQKELWKFAQCiWCGLCVSAC 164


                  ....
gi 1863504267 170 QAVA 173
Cdd:PRK12576  165 PVVA 168
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
14-61 1.92e-05

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 41.36  E-value: 1.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1863504267  14 LHINGEKHHLSV-DHRTTLLDALRErlDLTGTKKGCDQGQCGACTVLVD 61
Cdd:pfam00111   1 VTINGKGVTIEVpDGETTLLDAAEE--AGIDIPYSCRGGGCGTCAVKVL 47
Fer2_3 pfam13085
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 19-81 2.38e-04

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.


Pssm-ID: 432963 [Multi-domain]  Cd Length: 107  Bit Score: 38.76  E-value: 2.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1863504267  19 EKHHLSVDHRTTLLDAL---RERLDLTGT-KKGCDQGQCGACTVLVDRRRVVSCLTLAVTAQDREVT 81
Cdd:pfam13085  19 QEYEVPYEEGMTVLDALnkiKEEQDPTLAfRRSCREGICGSCAMNINGKPRLACKTLIDDLLGQDIT 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH