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Conserved domains on  [gi|1826566544|gb|QIR35702|]
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anti-sigma regulatory factor [Tolypothrix sp. PCC 7910]

Protein Classification

anti-sigma regulatory factor( domain architecture ID 13014755)

anti-sigma regulatory factor similar to RsbT, an ATPase with serine/threonine kinase activity that phosphorylates its antagonist RsbS and stimulates the phosphatase RsbU in a signaling cascade that results in active sigma-B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 14-127 2.37e-34

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


:

Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 115.55  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  14 DIVLVRQAVRQMSVEIGFSLVDQTKFVTAASELARNTLEYGGGGTVKLETLEEGRRRGLRLTFEDRGPGIADIALALKDG 93
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1826566544  94 FTTGSGLGMGLGGAKRLANEFEIQSVVGEGTRVT 127
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVV 114
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 14-127 2.37e-34

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 115.55  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  14 DIVLVRQAVRQMSVEIGFSLVDQTKFVTAASELARNTLEYGGGGTVKLETLEEGRRRGLRLTFEDRGPGIADIALALKDG 93
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1826566544  94 FTTGSGLGMGLGGAKRLANEFEIQSVVGEGTRVT 127
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVV 114
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
6-131 2.13e-16

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 69.94  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544   6 TLKIQSS-TDIVLVRQAVRQMSVEIGFSLVDQTKFVTAASELARNTLEYGGG----GTVKLE-TLEEGRrrgLRLTFEDR 79
Cdd:COG2172     1 SLSLPADlEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpdGPVEVElELDPDG---LEIEVRDE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1826566544  80 GPGIAdiALALKDGFTTGSGLGMGLGGAKRLANEFEIQSVVGeGTRVTIVRW 131
Cdd:COG2172    78 GPGFD--PEDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 35-128 3.51e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 40.32  E-value: 3.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544   35 DQTKFVTAASELARNTLEYGG-GGTVKLETLEEGRRrgLRLTFEDRGPGIA--DIALALKDGFTTGSGLGMGLGG----- 106
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPeGGRITVTLERDGDH--VEITVEDNGPGIPpeDLEKIFEPFFRTDKRSRKIGGTglgls 79

                           90       100
                   ....*....|....*....|....*..
gi 1826566544  107 -AKRLANEF----EIQSVVGEGTRVTI 128
Cdd:smart00387  80 iVKKLVELHggeiSVESEPGGGTTFTI 106
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 35-128 3.80e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 37.35  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  35 DQTKFVTAASELARNTLEYGGGGTVKLETLEEGRRrgLRLTFEDRGPGIADIALA-LKDGFTTGSGLGMGLG-----GAK 108
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE--LTLTVEDNGIGIPPEDLPrIFEPFSTADKRGGGGTglglsIVR 79

                          90       100
                  ....*....|....*....|....
gi 1826566544 109 RLAN----EFEIQSVVGEGTRVTI 128
Cdd:pfam02518  80 KLVEllggTITVESEPGGGTTVTL 103
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 14-127 2.37e-34

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 115.55  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  14 DIVLVRQAVRQMSVEIGFSLVDQTKFVTAASELARNTLEYGGGGTVKLETLEEGRRRGLRLTFEDRGPGIADIALALKDG 93
Cdd:cd16934     1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1826566544  94 FTTGSGLGMGLGGAKRLANEFEIQSVVGEGTRVT 127
Cdd:cd16934    81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVVV 114
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
6-131 2.13e-16

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 69.94  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544   6 TLKIQSS-TDIVLVRQAVRQMSVEIGFSLVDQTKFVTAASELARNTLEYGGG----GTVKLE-TLEEGRrrgLRLTFEDR 79
Cdd:COG2172     1 SLSLPADlEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpdGPVEVElELDPDG---LEIEVRDE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1826566544  80 GPGIAdiALALKDGFTTGSGLGMGLGGAKRLANEFEIQSVVGeGTRVTIVRW 131
Cdd:COG2172    78 GPGFD--PEDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKR 126
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 35-128 3.51e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 40.32  E-value: 3.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544   35 DQTKFVTAASELARNTLEYGG-GGTVKLETLEEGRRrgLRLTFEDRGPGIA--DIALALKDGFTTGSGLGMGLGG----- 106
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPeGGRITVTLERDGDH--VEITVEDNGPGIPpeDLEKIFEPFFRTDKRSRKIGGTglgls 79

                           90       100
                   ....*....|....*....|....*..
gi 1826566544  107 -AKRLANEF----EIQSVVGEGTRVTI 128
Cdd:smart00387  80 iVKKLVELHggeiSVESEPGGGTTFTI 106
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
33-129 2.22e-04

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 39.51  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  33 LVDQTKFVTAASELARNTLEYGG-GGTVKLETLEEGRRrgLRLTFEDRGPGIA--DIALALKDGFTTGSGLGMGLG---- 105
Cdd:COG0642   218 RGDPDRLRQVLLNLLSNAIKYTPeGGTVTVSVRREGDR--VRISVEDTGPGIPpeDLERIFEPFFRTDPSRRGGGTglgl 295

                          90       100
                  ....*....|....*....|....*....
gi 1826566544 106 -GAKRLAN----EFEIQSVVGEGTRVTIV 129
Cdd:COG0642   296 aIVKRIVElhggTIEVESEPGKGTTFTVT 324
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 35-128 3.80e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 37.35  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  35 DQTKFVTAASELARNTLEYGGGGTVKLETLEEGRRrgLRLTFEDRGPGIADIALA-LKDGFTTGSGLGMGLG-----GAK 108
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE--LTLTVEDNGIGIPPEDLPrIFEPFSTADKRGGGGTglglsIVR 79

                          90       100
                  ....*....|....*....|....
gi 1826566544 109 RLAN----EFEIQSVVGEGTRVTI 128
Cdd:pfam02518  80 KLVEllggTITVESEPGGGTTVTL 103
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
34-129 2.41e-03

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 36.42  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826566544  34 VDQTKFVTAASELARNTLEYGG-GGTVKLETLEEGRRrgLRLTFEDRGPGIADIALA-LKDGFTTGSGLGMGLGG----- 106
Cdd:COG2205   128 ADPELLEQVLANLLDNAIKYSPpGGTITISARREGDG--VRISVSDNGPGIPEEELErIFERFYRGDNSRGEGGTglgla 205

                          90       100
                  ....*....|....*....|....*...
gi 1826566544 107 -AKRLAN----EFEIQSVVGEGTRVTIV 129
Cdd:COG2205   206 iVKRIVEahggTIWVESEPGGGTTFTVT 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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