|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
17-374 |
1.14e-120 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 356.53 E-value: 1.14e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAV 176
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 177 VGIIIVQFFVPNPisQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPA 256
Cdd:cd17472 161 VSLLILLFFVPDP--PKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 257 FIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEK 336
Cdd:cd17472 239 ILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 1826022922 337 GSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTI 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-374 |
1.46e-43 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 156.97 E-value: 1.46e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVL 174
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 175 AVVGIIIVQFFVPNPISQAPKGDTLATP--AKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWML 252
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARlrSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 253 YFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCP 332
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP-LATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1826022922 333 VGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-351 |
1.77e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.03 E-value: 1.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 11 KKVAFSLASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAI 90
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADL--TRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLF 168
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAdlVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 169 LLTSVLAVVGIIIVQFFVPNPISQAPKgdtlATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEK 248
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARA----RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 249 HWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIA 328
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA-LAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|...
gi 1826022922 329 KFCPVGEKGSAMGVYSTSQFLGA 351
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-374 |
4.06e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 120.37 E-value: 4.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAqSVGLTGLFLLTSVL 174
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIgdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 175 AVVGIIIVQFFVPNPISQAPKGDTLATPAKLKKMLfDPQLFRLDAGIFILHLVLTAVFVALP--LDLVDAGLVKEKHWML 252
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALR-GRGLLTFLVSAFLYFFLYFAFLTYLPflLELLYGISPIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 253 YFPAFIGAFFLMVPLIIIGVKKNNTKTMFqLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCP 332
Cdd:cd17474 241 AGWSVLLALGSLFVGRLLKKRFGARRILV-IGLLLYALSLLLLG-FVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1826022922 333 VGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17474 319 EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-374 |
9.78e-27 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 110.38 E-value: 9.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 25 MMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:cd17489 9 FLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VFGRAVQG--MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:cd17489 88 LVLRLIHGigWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 183 qFFVPNPISQAPKGDTLATPAklKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLvkeKHWMLYFPAFIGAFF 262
Cdd:cd17489 168 -FLVKDPPPVAAEEAEAGTRA--FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 263 LMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGV 342
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS-FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350
....*....|....*....|....*....|..
gi 1826022922 343 YSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLA 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-352 |
4.37e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.27 E-value: 4.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLALAADL--TRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVL 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIAdwFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 175 AVVGIIIVQFFVPNPIS--QAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWML 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESkrPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 253 YFPAFIGAFFLMVPLIIIGVKKNNTKTM-FQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFC 331
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLlLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|.
gi 1826022922 332 PVGEKGSAMGVYSTSQFLGAF 352
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-374 |
9.39e-25 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 104.58 E-value: 9.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALYGQHL--EGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYG 103
Cdd:cd17330 10 LGFGIVFPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 104 VVFGRAVQGM-GAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:cd17330 90 LFLARFLDGLtGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 183 QFFVPNpisqapkgdtlatpaklkkmlfdpqLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHwMLYFPAFIGAFF 262
Cdd:cd17330 170 LFFLPP-------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQ-IGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 263 LMVPLIIIGV--KKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAM 340
Cdd:cd17330 224 ILAQLLLIPRlaKRLGERKLLRLGLLLAIIGLLLLP-FASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350
....*....|....*....|....*....|....
gi 1826022922 341 GVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17330 303 GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-374 |
5.46e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.93 E-value: 5.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 28 LFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFG 107
Cdd:cd17324 15 EYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 108 RAVQGM--GAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFF 185
Cdd:cd17324 94 RALAGLahGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 186 VPNpiSQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMV 265
Cdd:cd17324 174 LPS--LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 266 PLIIIGVKKNNTKTMFQLSLLImMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGeKGSAMGVYST 345
Cdd:cd17324 252 PLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLA 329
|
330 340
....*....|....*....|....*....
gi 1826022922 346 SQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17324 330 AYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-374 |
1.56e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.65 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLAL--AADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQ--SVGLTGLFLLTS 172
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLalIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 173 VLAVVGIIIVQFFVPNPISQAPKGDTLATPAK----LKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVD-AGLVKE 247
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 248 KHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLpSLI 327
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF-ALI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1826022922 328 AKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLV 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-373 |
3.25e-21 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 94.60 E-value: 3.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVV 105
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 106 FGRAVQGMGAIAAA--VLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSvGLTGLFLLTSVLAVVGIIIVQ 183
Cdd:cd17329 93 IALVLTGFGGGLFEpaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 184 FFVPNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFL 263
Cdd:cd17329 172 FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 264 MVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVY 343
Cdd:cd17329 252 LQFPVARLVERFRLRKILMIGILLFAIGFAVLA-FANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
|
330 340 350
....*....|....*....|....*....|
gi 1826022922 344 STSQFLGAFCGGMLGGGAYQLLGASGVFFV 373
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLLLDLLGPGLPWLI 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-374 |
6.59e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.18 E-value: 6.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 25 MMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:COG2223 17 AFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VFGRAVQGMGAIAAAVLALAADLT--RDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:COG2223 97 LLLGLLLGIGGGGSFAVGIALVSKwfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 183 QFFVPNPiSQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYfpAFIGAFF 262
Cdd:COG2223 177 WLFLRDP-PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL--AALFALL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 263 LMVPLIIIGV---KKNNTKTMFqLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSA 339
Cdd:COG2223 254 GALGRPLGGWlsdRIGGRRVLL-IVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV 332
|
330 340 350
....*....|....*....|....*....|....*
gi 1826022922 340 MGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLV 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
17-359 |
7.95e-20 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 90.71 E-value: 7.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:cd17320 4 LALLVALGPLAIDMYLPALPAIARDL-GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVL 174
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVrdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 175 AVVGIIIVQFFVPNPISQAPKGDTLATPAK-LKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLY 253
Cdd:cd17320 163 GLLLLLLVLLFLPETLPEEKRKPLLSSLLRaYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 254 FPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLFA----DNLWVLSIAVVLFFTGFNYLEASLPSLIAK 329
Cdd:cd17320 243 FALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllggLSLWPLVAPLFLIFFGFGLIFPNATSLALE 322
|
330 340 350
....*....|....*....|....*....|
gi 1826022922 330 FCPvGEKGSAMGVYSTSQFLGAFCGGMLGG 359
Cdd:cd17320 323 PFP-HVAGTASALLGFLQFLIGALAGALVG 351
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-352 |
3.08e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.09 E-value: 3.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 15 FSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLI 94
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 95 AASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTR--DEQRTKVMAVIGMCIGFSFALSLLVGPIVAqSVGLTGLFLLTS 172
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYfeGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 173 vLAVVGIIIVQFFVPNPisQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHwml 252
Cdd:cd17473 161 -LALPVLILVLLFLPEP--ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAL--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 253 yFPAFIGAFFLMVPLIIIG----VKKNNTKTMFQLSLLIMMAALAAMGLfADNLWVLSIAVVLFFTGFNYLEASLPSLIA 328
Cdd:cd17473 235 -IGLALAIASLAGAIGALLfgrlKRRLGKRRLLAIGFALMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340
....*....|....*....|....
gi 1826022922 329 KFCPVGEKGSAMGVYSTSQFLGAF 352
Cdd:cd17473 313 SLVPPELRGRAMGIVTSAFFLGQF 336
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-359 |
1.05e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 84.17 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 46 SPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAA 125
Cdd:cd17504 29 SAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 126 DLTRDEQRTKV-MAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPnpisqapkgdtlatpak 204
Cdd:cd17504 109 REEFPPERVPVaQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL----------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 205 lkKMLFDPQLFRLDAGIFILHLVLTAVFVALPLdlvdagLVKEKHWMLYFPAFIGAFFLMVPLIIIG----------VKK 274
Cdd:cd17504 172 --RLLRRRNVLLANITALLAGFGMFMVFQLLPQ------LLQLPTPTGFGLGITEAGLLLLPGALVMliagplagrlIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 275 NNTKTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCG 354
Cdd:cd17504 244 VGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323
|
....*
gi 1826022922 355 GMLGG 359
Cdd:cd17504 324 PAIAG 328
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-374 |
2.16e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 83.38 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 29 FMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGR 108
Cdd:COG2271 26 RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 109 AVQGMGAIAAAVLALAADLT--RDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIvqffv 186
Cdd:COG2271 106 FLLGLGEAGFFPAALKLIAEwfPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 187 pnpisqapkgdtlatpaklkkmlfdpQLFRLDAGIFILHLVLTAVFVALPLDLVDA-GLVKEKHWMLYFPAFIGAFFLMV 265
Cdd:COG2271 181 --------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 266 PLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYST 345
Cdd:COG2271 235 LGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNT 314
|
330 340
....*....|....*....|....*....
gi 1826022922 346 SQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:COG2271 315 FGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-186 |
1.38e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 15 FSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLI 94
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 95 AASSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTS 172
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLadIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
170
....*....|....
gi 1826022922 173 VLAVVGIIIVQFFV 186
Cdd:cd17325 362 ALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-366 |
1.88e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 81.10 E-value: 1.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 12 KVAFSLASvFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYG-----RKPIIMAGLV 86
Cdd:COG2211 12 KLAYGLGD-LGLNLAFGLLSAYLLYFYTDVL-GLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 87 LFAIGSLIAASSDH-------IYGVVFGRAVQ-GMGAIAAAVLALAADLTRD-EQRTKVMAVIGMCIGFSFALSLLVGPI 157
Cdd:COG2211 90 PLALSFVLLFTAPDlsptgklIYALVTYLLLGlAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 158 VAQSV------GLTGLFLLTSVLAVVGIIIVQFFVPNPISQAPKGDTLAtpAKLKKMLFDPQLFRLDAGIFILHLVLTAV 231
Cdd:COG2211 170 LVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLK--ESLKALLKNRPFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 232 FVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLF-ADNLWVLSIAVV 310
Cdd:COG2211 248 AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAA 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1826022922 311 LFFTGFNYLEASLPSLIAKFCPVGEK-------GSAMGVYSTSQFLGAFCGGMLGGGAYQLLG 366
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
26-374 |
1.28e-15 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 78.03 E-value: 1.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYG-RKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:cd17490 10 FSQYVYVPFLSPYAESL-GASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VFGRAVQGMGAIA--AAVLALAADLTRDEQrTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:cd17490 89 LIARFLSGIAAATwvSFTVLYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 183 qFFVPNPisQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTA-VFVALPLDLVDAGLVKEKHWMLYF----PAF 257
Cdd:cd17490 168 -LFIKEE--RREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFStTFGFTPLIAKQLGASSFQLGLLSIiyllPNA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 258 IGAFFLMVPLIiigvKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKG 337
Cdd:cd17490 245 LASLLSGTLFY----KKLGERNTIIIGFLLLGAYCFLIP-FAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 1826022922 338 SAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17490 320 TAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVI 356
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-272 |
1.75e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.77 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 11 KKVAFSLASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAI 90
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQGMG--AIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLF 168
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGagGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 169 LLTSVLAVVGIIIVQFFVPNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEK 248
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260
....*....|....*....|....
gi 1826022922 249 HWMLYFPAFIGAFFLMVPLIIIGV 272
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALL 275
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
44-351 |
4.18e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 73.36 E-value: 4.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLAL 123
Cdd:cd17321 27 GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 124 AADLT--RDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFvpnpisqapkgdTLAT 201
Cdd:cd17321 107 ALIAAtfPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF------------SGAV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 202 paklkkmlfdpqlfrldAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMF 281
Cdd:cd17321 175 -----------------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1826022922 282 QLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNY--LEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGA 351
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLglFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-373 |
6.93e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 69.51 E-value: 6.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 22 GLRMMGLFMIMPVFALYGqHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHI 101
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 102 YGVVFGRAVQGMGAIAAAVLA--LAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLtgLFLLTSVLAVVGI 179
Cdd:cd17477 85 WVWFLLRFVMGIGLAGLFVVSesWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 180 IIVqFFVPNPISQAPKGDTLATPAKLKKMlfdPQLFrldAGIFILHLVLTAVFVALPLDLVDAGL-VKEKHWMLYFpAFI 258
Cdd:cd17477 163 VPL-LLTRRAAPEIEEAESISLRRLLRIA---PLAL---LGAFVAGFLEGAFYSLLPLYGLRLGLsVAQAALLLAA-FVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 259 GAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLpSLIAKFCPVGEKGS 338
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLAL-ALAGDRLPGDELVA 313
|
330 340 350
....*....|....*....|....*....|....*
gi 1826022922 339 AMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFV 373
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
44-393 |
6.75e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.82 E-value: 6.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLAL 123
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 124 AADLTR-DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQAPKGdtlATP 202
Cdd:COG2807 129 GLIKRWfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA---PAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 203 AKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKH-WMLYFPAFIGAFF-LMVPLIIigVKKNNTKTM 280
Cdd:COG2807 206 ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAgLLLSLFQLAGIPGsLLVPLLA--DRLGDRRPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 281 FQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNY-LEASLPSLIAKfcPVGEKGSAMGVYSTSQFLGAFCGGMLGG 359
Cdd:COG2807 284 LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFpLALTLIGLRAR--TPAEAAALSGMAQSVGYLLAALGPLLVG 361
|
330 340 350
....*....|....*....|....*....|....*
gi 1826022922 360 GAYQLLGA-SGVFFVALALMFLWLLLTFGMAKPVL 393
Cdd:COG2807 362 ALHDATGSwTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
25-374 |
2.44e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 64.98 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 25 MMGLFMIMPVFALYGQHLEGFSP----LWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDH 100
Cdd:cd17391 9 GIGFSLIAPFLPLYIEQLGVTSGglveLWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 101 IYGVVFGRAVQGMGAIAAAVLALAADLTRDEQRT-KVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGI 179
Cdd:cd17391 89 VWQLLILRLLQGVFSGYVPNATALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 180 IIVQFFVPNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPL---DL-VDAGLVKEKHWMLYFP 255
Cdd:cd17391 169 LLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLyirQLmGDASNLAFISGLVFSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 256 AFIGAFFLMVPLIIIGVKKNNTKtmfqlslLIMMAALAAMGL-----FADNLWVLSIAVVLFFTGFNYLEASLPSLIAKF 330
Cdd:cd17391 249 TGVSSLLSAPRLGKLGDRIGHHR-------ILLGALLASALLyipqaFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1826022922 331 CPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVT 365
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-362 |
1.22e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 63.04 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 23 LRMMGLFMIMPVF-ALYGQ--HLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSD 99
Cdd:cd17388 10 LDAMGIGLIMPVLpTLLREfvGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 100 HIYGVVFGRAVQG-MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQsVGLTGLFLLTSVLAVVG 178
Cdd:cd17388 90 TLWWLYLGRIIAGiTGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLNGLN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 179 IIIVQFFVP---NPISQAPKGDTLATP-AKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLdlvdagLVKEK-HW--- 250
Cdd:cd17388 169 FLLGLFVLPeslPPERRRAFRWRRANPfGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVL------FTEDRfDWspt 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 251 MLYFP-AFIGAFFLMVPLIIIG--VKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEAsLPSLI 327
Cdd:cd17388 243 MVGLSlAVFGLLHALFQAFVTGpiAKRLGEKRAILLGLAADALGFLLLA-FATQGWMVFPILILLALGGIAGPA-LQGLL 320
|
330 340 350
....*....|....*....|....*....|....*
gi 1826022922 328 AKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAY 362
Cdd:cd17388 321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF 355
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-374 |
1.25e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 62.95 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDK-YGRKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:cd17471 10 LAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VF-GRAVQGMGAIAA----AVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGI 179
Cdd:cd17471 90 LLvGVVLLSLGAAAFpqlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 180 IIVQFFVPNPISQAPKGDtlaTPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKH--WMLYFPAf 257
Cdd:cd17471 170 LLVLFLLPSVKPPAQKAT---PASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWvgLLFGLAA- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 258 igafFLMVPLIIIG---VKKNNTKTMFQLSLLIMMAALAAMgLFADNLWVLSIAVVL--FFTGFNyleASLP-SLIAKFC 331
Cdd:cd17471 246 ----ALEIPIMLLAgllAKRFGKRRLLLAGFLAGVLFYLGL-ALATSLWQLIALQLLnaIFIGIT---AGLGiSYFQDLM 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1826022922 332 PvGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17471 318 P-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVC 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-374 |
8.24e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 60.25 E-value: 8.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYG-RKPIIMAGLVLFAIGSLIAASSDHIYGVVFGR 108
Cdd:cd17370 17 MARSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 109 AVQGMGAIAAAVLalaadltRDEQRTKVMAVIGMCIGFSFALSL-----LVGPIVA------QSVGLTGLFLLTSVLAVV 177
Cdd:cd17370 96 ILERLGKGIRTPP-------RDALLADATPPSGRGKAFGLHRALdtlgaVLGPLLAalllylLGGNYRTIFLLAAIPALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 178 GIIIVQFFVPNPIsqaPKGDTLATPAKLKKMLFDPQLFRLDAGIFILhlVLTAVFVALPLDLVDAGLVKEKHWMLYFPAF 257
Cdd:cd17370 169 ALLILLFVVKEYP---RPPKLRKKSKKTSLKKLPKAFWLYLLAVALF--ALGNFSFAFLILRAQELGLSAALIPLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 258 IGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMgLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKG 337
Cdd:cd17370 244 NLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF-ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
330 340 350
....*....|....*....|....*....|....*..
gi 1826022922 338 SAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-374 |
5.78e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.63 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 16 SLASVFGLRMmgLFMIMPVFALYGQHlegfSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIA 95
Cdd:cd06173 8 QLLSALGDWI--FTVALPWLVLQLTG----SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 96 A--------SSDHIYGVVFGRAVQGmGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGL 167
Cdd:cd06173 82 AllallgslSLWLLLVLAFLLGIAS-AFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 168 FLLTSVLAVVGIIIVQFFVPNPISQAPKGDTLATPAK---LKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGL 244
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 245 VKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLP 324
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG-LSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1826022922 325 SLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
23-374 |
8.35e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 56.85 E-value: 8.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 23 LRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIY 102
Cdd:cd17390 7 LDLFGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 103 GVVFGRAVQG-MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQ-SVGLTGLFLLTSVLAVVGII 180
Cdd:cd17390 86 LLFLSRIPLGiFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNAG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 181 IVQFFVPNpisqapkgdtlatpaklkkmLFDPQLFRldagiFILHLVLTAVFVALPLDLVDAGLVKEKH--WMLYFPAFI 258
Cdd:cd17390 166 LVWFLLSK--------------------LWDLLLVR-----FLMGFSVLLFRSNFSLYLEERFDLSPKTigYLISYSGVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 259 GAfflMVPLIIIGVKK---NNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGE 335
Cdd:cd17390 221 GA---LSGFLVGRILKlykNNEYLLLLHSFILLALSLLGLA-LAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKE 296
|
330 340 350
....*....|....*....|....*....|....*....
gi 1826022922 336 KGSAMGVYSTSQFLGAFCGGMLGGGAYQlLGASGVFFVA 374
Cdd:cd17390 297 RGTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLG 334
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-182 |
1.08e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.78 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 32 MPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQ 111
Cdd:cd17370 219 FAFLILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILW 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1826022922 112 G--MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIG-FSFALSLLVGpIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:cd17370 298 GlyMGAQESIERAAVADLVPAELRGTAYGLFNTVVGiGWLLASLIAG-YLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
44-312 |
1.79e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLAL 123
Cdd:COG0738 39 GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAAN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 124 AADLTR-DEQRTKVMAVIGMCIGF-SFALSLLVGPIVAQSVGLT--GLFLLTSVLAVVGIIIVqFFVPNPISQAPKGDTL 199
Cdd:COG0738 119 PYVAALgPETAASRLNLLHAFFSLgALLGPLLGGLLILLGLSLSwhLPYLILAVLLLLLALLF-LRSKLPEIEEEEEEAA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 200 ATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKT 279
Cdd:COG0738 198 GSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR 277
|
250 260 270
....*....|....*....|....*....|...
gi 1826022922 280 MFQLSLLIMMAALAAMgLFADNLWVLSIAVVLF 312
Cdd:COG0738 278 LLRLSALLAAVGLLLA-LLAPGPWLALIGLALV 309
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-151 |
2.17e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 12 KVAFSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIG 91
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1826022922 92 SLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTR--DEQRTKVMAVIGMCIGFSFALS 151
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELapPEARGRASGLYNSAFFLGGPLA 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-185 |
3.84e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIA- 95
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLf 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 96 -ASSDHIYGVVFGRAVQGMGAIAAAVLALAAD---LTRDEQRT------KVMAVIGMCIGFSFALSLLVGPIVAQSVG-- 163
Cdd:COG2211 313 fLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLLALFGyv 392
|
170 180 190
....*....|....*....|....*....|....*
gi 1826022922 164 -------------LTGLFLLTSVLAVVGIIIVQFF 185
Cdd:COG2211 393 agaaqspsaltgiRLLFFLLPAVLLLLAALLLLFY 427
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-354 |
5.50e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 5.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 50 VGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLT- 128
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRw 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 129 -RDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVV-GIIIVQFFVPNPISQAPKGDTLATPAKLK 206
Cdd:cd17475 113 fPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILaAVLFWLFYREPPAASAATESASTLLRSLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 207 KMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKH--WMLyFPAFIGAFFLMVPLIIIG--VKKNNTKTMFQ 282
Cdd:cd17475 193 EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAagALL-AVAQLGGALGRIGLGRVSdrVFGGRRRPVLV 271
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1826022922 283 LSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGF-----NYLEAslpSLIAKFCPVGEKGSAMGVYSTSQFLGAFCG 354
Cdd:cd17475 272 ITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLfaigwNGLYL---TLVAESAGPEQAGTALGLANTINFIGIAIG 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
55-315 |
1.06e-07 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 53.76 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 55 GAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGaiAAAVLALAADLTRD---- 130
Cdd:PRK11652 50 AAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG--TGVGGVMARTLPRDlyeg 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 131 EQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVL-AVVGIIIVQFFVPNPISQAPKGDTLATpaklKKML 209
Cdd:PRK11652 128 TQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLgAGVTFSMARWMPETRPADARRTRVLAS----YRTL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 210 FDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWM-LYF-----PAFIGAFFLMVPliiigvKKNNTKTMFQL 283
Cdd:PRK11652 204 LSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLSSMTVsILFilpipAAFFGAWFAGRP------NKRFSTLMWQS 277
|
250 260 270
....*....|....*....|....*....|....*
gi 1826022922 284 SLLIMMAALAAM--GLFA-DNLWVLSIAVVLFFTG 315
Cdd:PRK11652 278 VICCLLAGLLMWipGWFGvMNVWTLLVPAALFFFG 312
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
22-195 |
1.41e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 53.36 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 22 GLRMMGLF---MIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASS 98
Cdd:PRK11043 13 GLSMLGFLatdMYLPAFKAIQADL-QTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 99 DHIYGVVFGRAVQGMGAIAAAVLALAADLTR-DEQRT-KVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAV 176
Cdd:PRK11043 92 ESAAQLLVLRFVQAVGVCSAAVIWQALVIDRyPAQKAnRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITL 171
|
170
....*....|....*....
gi 1826022922 177 VGIIIVQFFVPNPISQAPK 195
Cdd:PRK11043 172 LLILPTLRLKPSKKARKQS 190
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
53-350 |
3.25e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.19 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 53 AIGAYGLTQAILqIPM-GILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGM--GAIAAAVLALAADLTR 129
Cdd:cd17503 36 VITSYLLALAIM-IPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFggGVLIPLAQTILLRIYP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 130 DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPnpisqapkgdtlatpaklkKML 209
Cdd:cd17503 115 PEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLDL-------------------RLF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 210 FDPQLFRLDAGIFILHLVLTAVFVALPLDL-VDAGLVKEKHWMLYFPAFIGAFFLMvPLIIIGVKKNNTKTMFQLSLLIM 288
Cdd:cd17503 176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLqNVLGYSAFESGLVLAPGGLASAILS-PLVGRLLDKFGPRLLLLAGLLLL 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1826022922 289 MAALAAMGLFADNLWVLSIAVVLFFTGFNY--LEASLPSLIAKFCPVGEKGSAMGVYSTSQFLG 350
Cdd:cd17503 255 ALGTLLLAFLTPDTSLWLIILPLFIRGLGMglVFMPLNTLALNSLPPEQIGDATALFNTIRQLG 318
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
11-312 |
1.91e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 49.69 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 11 KKVAFSLASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAI 90
Cdd:TIGR00710 4 KAFALLLGCLSILGPLGIDMYLPAFPEIAADL-STPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADltRD----EQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTG 166
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALV--RDiypgEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 167 LFLLTSVLAVVGIIIVQFFVP------NPISQAPKGDTLATPAKLKKMLfdpqLFRLDAGIFilHLVLTAVFVALPLDLV 240
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPetlpyeARIQISTYFETFLLLLKSKMFW----GYALIYGAS--FGGFFAFFSGAPFVYI 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1826022922 241 DAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMA---ALAAMGLFADNLWVLSIAVVLF 312
Cdd:TIGR00710 235 DIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVsavLLEITAILGLGSWAMIIGPMMF 309
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
56-160 |
2.44e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.93 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 56 AYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAAD-LTRDEQRT 134
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASeLVPNKYRG 119
|
90 100
....*....|....*....|....*.
gi 1826022922 135 KVMAVIGMCIGFSFALSLLVGPIVAQ 160
Cdd:cd06179 120 LVQGVVNLVASPGSALGPLIAGALVE 145
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-114 |
2.79e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 49.17 E-value: 2.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRA 109
Cdd:PRK15402 31 MIQPGMLAVVEDF-NAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRF 109
|
....*
gi 1826022922 110 VQGMG 114
Cdd:PRK15402 110 LQGIG 114
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
23-358 |
2.86e-06 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 49.29 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 23 LRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIY 102
Cdd:PRK11646 21 LVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPW 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 103 GVVFGRAVQGMGAIAA--AVLALAADLTRDEQRTKVM----------AVIGMCIG-----FSFALSLLVGpivaqsvglT 165
Cdd:PRK11646 101 LLWLSCILSGLGGTLFdpPRTALVIKLIRPHQRGRFFsllmmqdsagAVIGALLGswllqYDFRLVCATG---------A 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 166 GLFLLTSVLAVvgiiivqFFVPnpisqAPKGDTLATPAK--LKKMLFDPQLFRLD---AGIFILHLvltAVFVALPLDLV 240
Cdd:PRK11646 172 VLFVLAAAFNA-------WLLP-----AYKLSTVRTPVRegMTRVLRDKRFVTYVltlTGYYMLAV---QVMLMLPIMVN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 241 D-AGLVKEKHWMLYFPAFIgAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLfADNLWVLSIAVVLFFTGFNYL 319
Cdd:PRK11646 237 DiAGSPSAVKWMYAIEACL-SLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGM-VSNLQQLFTLICLFYIGSIIA 314
|
330 340 350
....*....|....*....|....*....|....*....
gi 1826022922 320 EASLPSLIAKFCPVGEKGSAMGVYStsqfLGAFCGGMLG 358
Cdd:PRK11646 315 EPARETLSASLADARARGSYMGFSR----LGLALGGAIG 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-187 |
4.61e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGR--KPIIMAGLVLFAIGSLI 94
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 95 AASSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTS 172
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAaeLFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344
|
170
....*....|....*
gi 1826022922 173 VLAVVGIIIVQFFVP 187
Cdd:COG2271 345 ALALLAALLALLLLR 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-183 |
5.41e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 48.31 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 25 MMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:cd17324 211 FGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VFGRAVQGMGAIAAAVLALAADLTRD-EQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQ 183
Cdd:cd17324 291 LVGLVLWGLGFFAAHSALQTRVLRLApEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-328 |
9.20e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 9.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRA 109
Cdd:cd17478 14 FLPALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 110 VQGMGAIAA-AVLALAADLTRDEQRTKVMAV--IGMCIGFSFAlSLLVGPIVAQSvGLTGLFLLTSVLAVVGIIIVqFFV 186
Cdd:cd17478 93 LAGIGSAAFhPEGARLASQAAGGRRGLAMSIfsVGGNLGFALG-PLIAAALVALF-GGLGLLILLIIPGLAVALLL-LRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 187 PNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGlvkekhwmlYFPAFIGAF-FLMV 265
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG---------YSLVFAGLLlSLFL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 266 PLIIIG-------VKKNNTKTMFQLSLLIMMAALAAMgLFADNLWVLsiaVVLFFTGFNyLEASLPSLIA 328
Cdd:cd17478 241 FAGAIGtliggplSDRFGRRRVIIASLLLAAPFLLLF-LLTPGIWSY---ILLVLAGFL-LFASFPVTVV 305
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-114 |
1.15e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 15 FSLASVFG-LRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSL 93
Cdd:cd17503 180 FTLGLLLSfLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100
....*....|....*....|....
gi 1826022922 94 IAASSDH---IYGVVFGRAVQGMG 114
Cdd:cd17503 260 LLAFLTPdtsLWLIILPLFIRGLG 283
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-196 |
1.15e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.23 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 59 LTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKV 136
Cdd:cd17328 45 ISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIadLFPKEKRTRA 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1826022922 137 MAVIGMCIGFSFALSLLVGPIVAQSVGLTGL-FLLTSVLAVVGIIIVQFFVPNPISQAPKG 196
Cdd:cd17328 125 LGVFYFAIPLGSGLGYVVGGLVAQATGGWRWaFRVTGVLGVLLAILLLLFVREPPRGAAEG 185
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-182 |
1.62e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 25 MMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGV 104
Cdd:cd06173 221 ALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 105 VFGRAVQGMGAIAAAVLALAADLTR--DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIV 182
Cdd:cd06173 301 LAALFLLGLAGGLFNVPLNTLLQLRvpDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
68-367 |
1.76e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 46.88 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 68 MGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQG-MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGF 146
Cdd:cd17389 84 TGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGiSKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 147 SFALSLLVGPIVAQSVGLTGLF------LLTSVLAVVGIIIVQFFVPnpisqapkgDTLatpaklkkmlfdPQLFRLDAG 220
Cdd:cd17389 164 GFIIGPMIGAYFASFTRSLGEVffsmpaLFALVLALADLLFIFFFLP---------ETL------------PSNLRRLGL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 221 IFILHLVL------TAVFVA---LPLDLVDAGlvkekhwMLYFpaFIGafFLMVplIIIG-----VKKNNTKTMFQLSLL 286
Cdd:cd17389 223 VYFLYLFLfsglefTLTFLThqrFQYTSMQQG-------KMFF--FIG--IIMA--LVQGgyvrrIKPGKEKKAVLQGLI 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 287 IMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLG 366
Cdd:cd17389 290 LLIPAFLLIG-WASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAG 368
|
.
gi 1826022922 367 A 367
Cdd:cd17389 369 S 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-374 |
1.78e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.79 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 36 ALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGA 115
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 116 IAAAVLALAADLTR--DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPIsqa 193
Cdd:cd17319 106 AGFFPGAIKALAEWfpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 194 pkGDTLATpaklkkmlfdpqlFRLDAGIFILHLVLTAVFV-ALPLDLVDAGLVKekhWMLYFPAFIGAFFlmVPLIIIGV 272
Cdd:cd17319 183 --GLALGY-------------FGINYALYGLLTWLPTYLKqARGFSLKQVGLLA---AIPFLAGAIGMIL--GGRLSDRL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 273 KKNNTKTMFQLSLLIMMAALAAMGlFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAF 352
Cdd:cd17319 243 LRGARRLVIIIGLLLAAVGLLLAY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGF 321
|
330 340
....*....|....*....|..
gi 1826022922 353 CGGMLGGGAYQLLGASGVFFVA 374
Cdd:cd17319 322 VAPLLIGYLVDATGSYTAAFLF 343
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
30-313 |
1.97e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 46.45 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRA 109
Cdd:PRK11102 9 MYLPALPVIAADF-GVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 110 VQGMgaIAAAVLALAADLTRD----EQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFF 185
Cdd:PRK11102 88 LHGL--AAAAASVVINALMRDmfpkEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 186 VPNpisqapkgdtlaTPAKLKKMLFDpqlFRLDAGIFI--------LHLVLTAVF---------VALPLDLVDAGLVKEK 248
Cdd:PRK11102 166 IPE------------TLPKERRQPFH---LRTTIRNFAslfrhkrvLGYMLASGFsfagmfsflTAGPFVYIELNGVSPQ 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826022922 249 HWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSL---LIMMAALAAMGLFADNLWVLSIAVVLFF 313
Cdd:PRK11102 231 NFGYYFALNIVFLFVMTIINSRFVRRVGALNMLRFGLwiqFIMGIWLVVSALLDLGFWALVVGVAAFV 298
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
15-390 |
2.00e-05 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 46.59 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 15 FSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVL-FAIGSL 93
Cdd:PRK12382 18 FRIAFAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLAcGLAGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 94 IAASSDHIYGVVF-------GRAVQGMGAIAAAVLALA-ADLTRDEQRT-KVMAVIGMCIGFSFALSLLVGPIVAQSVGL 164
Cdd:PRK12382 98 YLLAAILPVSAPFkfallvvGRLILGFGESQLLTGALTwGLGLVGPKHSgKVMSWNGMAMYGALAAGAPLGLLLHSHFGF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 165 TGLFLLTSVLAVvgiiIVQFFVPNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGIfilHLVLTAVFVALpldlvdagL 244
Cdd:PRK12382 178 AALALTTMVLPL----LAWAFNGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGV---GFAVIGTFVSL--------Y 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 245 VKEKHWM---LYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLfADNLWVLSIAVVLFFTGFNYLEA 321
Cdd:PRK12382 243 FASKGWAmagFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWL-APTAWVALAGAALTGAGCSLIFP 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1826022922 322 SLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVALALMFLWLLLTFGMAK 390
Cdd:PRK12382 322 ALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFR 390
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
66-359 |
2.45e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 66 IPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTR-DEQRTKVMAVIGMCI 144
Cdd:cd17333 49 LLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALfEESSATRLNVLHGFF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 145 GF-SFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQF--FVPNPISQAPKGDTLATPAKLKKMLFDPQLFRLDAGI 221
Cdd:cd17333 129 GLgALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLtlFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 222 FILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALaAMGLFADN 301
Cdd:cd17333 209 FLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGL-LILLLAPT 287
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1826022922 302 LWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVgEKGSAMGVYSTSQFLGAFCGGMLGG 359
Cdd:cd17333 288 LVVGLVATALLGLFMAALFPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
44-374 |
3.20e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 3.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQG--MGAIAAAVL 121
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGigIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 122 ALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLT----GLFLLTSVLAVVGIIIVQFFVpnpisqapkgd 197
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTL----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 198 tlatpaklkkmlfdpqlfRLDAGIFILHLVLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNT 277
Cdd:cd17316 181 ------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 278 KTMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFN-YLEASLPSLIAKFCPVGEKGSAMGV-YSTSQFLGAFCGG 355
Cdd:cd17316 243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVgGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPP 322
|
330
....*....|....*....
gi 1826022922 356 MLGGGAYQLLGASGVFFVA 374
Cdd:cd17316 323 LIALLLASTGGTGVPALIL 341
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-366 |
3.65e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 3.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 16 SLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIA 95
Cdd:cd17355 6 AVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 96 ASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTR---DEQRTKVMAVIGMCIGF-SFALSLLVGPIVAQSVGLTGLFLLT 171
Cdd:cd17355 86 ALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAwwfERRRGLALGILTAGGGLgSLVFLPLGAALIEAFGWRTALLVLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 172 SVLAVVGIIIVQFFVPNPISQAPKGDTLATPAK----LKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDAGL-VK 246
Cdd:cd17355 166 LLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGIsPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 247 EKHWMLyfpAFIGAfFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGL-FADNLWVLSIAVVLFFTGFNYLEASLPS 325
Cdd:cd17355 246 AAAVAL---ALIGL-FNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLlLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1826022922 326 -LIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLG 366
Cdd:cd17355 322 aLAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
52-188 |
5.38e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 52 IAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADL--TR 129
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIAdlFT 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1826022922 130 DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPN 188
Cdd:cd17323 118 PEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
69-359 |
7.56e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 7.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 69 GILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSF 148
Cdd:TIGR00895 73 GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPI 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 149 ALSL--LVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPI---------------------SQAPKGDTLATPAK- 204
Cdd:TIGR00895 153 GAAVggFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdflvskrpetvrrivnaiapqMQAEAQSALPEQKSt 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 205 ------LKKMLFDPQLFRLDAGIFILHLVLTAVFVAL----PLDLVDAG--LVKEKHWM--LYFPAFIGAFFLMVPLIII 270
Cdd:TIGR00895 233 qgtkrsVFKALFQGKTARITVLLWLLYFMLLVGVYFLtnwlPKLMVELGfsLSLAATGGalFNFGGVIGSIIFGWLADRL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 271 GVkknntKTMFQLSLLI-MMAALAAMGLFADNLWVLSIAVVLFFTGFNYleASLPSLIAKFCPVGEKGSAMGVYSTSQFL 349
Cdd:TIGR00895 313 GP-----RVTALLLLLGaVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQ--SGLYALMALFYPTAIRATGVGWAIGIGRL 385
|
330
....*....|
gi 1826022922 350 GAFCGGMLGG 359
Cdd:TIGR00895 386 GAIIGPILAG 395
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
44-114 |
7.91e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 44.72 E-value: 7.91e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMG 114
Cdd:PRK10504 41 GESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
69-114 |
9.01e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 44.63 E-value: 9.01e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1826022922 69 GILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMG 114
Cdd:PRK10473 59 GKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIG 104
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
53-185 |
1.11e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.18 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 53 AIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTRDE- 131
Cdd:cd17476 38 LAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPp 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1826022922 132 --QRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFF 185
Cdd:cd17476 118 gpRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFW 173
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
51-158 |
1.38e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 43.74 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 51 GIAIGAYGLTQAILQIPMGILSDKYG-RKPIIMAGLVLFAIGSLIAASSDHI-----YGVVFGRAVQGMGAIAAAVL-AL 123
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFpsnrkYVMLVARFLIGVGAGNVAVLrAY 118
|
90 100 110
....*....|....*....|....*....|....*
gi 1826022922 124 AADLTRDEQRTKVMAVIGMCigfsFALSLLVGPIV 158
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAA----QALGFIVGPAL 149
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
50-114 |
1.49e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.80 E-value: 1.49e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826022922 50 VGIAIGAYGltqailqipMGILSDKYGRKPIIMAGLVLFAIGSLIAASSD---HIYGVVFGRAVQGMG 114
Cdd:pfam00083 57 VGCFIGSLF---------AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIG 115
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-97 |
1.71e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 12 KVAFSLASVFGLRMMGLFMIMPVFALygqhLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIG 91
Cdd:cd17477 191 PLALLGAFVAGFLEGAFYSLLPLYGL----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALA 266
|
....*.
gi 1826022922 92 SLIAAS 97
Cdd:cd17477 267 ALLLPL 272
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-114 |
2.30e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 14 AFSLASVFGLRMMGLFMIMPVF-ALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGS 92
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLlPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
90 100
....*....|....*....|....*
gi 1826022922 93 LIAA---SSDHIYGVVFGRAVQGMG 114
Cdd:cd17321 249 LLLAllgADSSVWLLLPGLVLLGLG 273
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-185 |
2.37e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 17 LASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAA 96
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 97 SSDH---IYGVVFGRAVQGMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGF-SFALSLLVGPIVAQSVGLTGLFLLTS 172
Cdd:COG2223 290 LALGslwLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATGSYTAAFLVFA 369
|
170
....*....|...
gi 1826022922 173 VLAVVGIIIVQFF 185
Cdd:COG2223 370 VLALVALVLTLLL 382
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-185 |
3.82e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 12 KVAFSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMG-ILSDKYGRKPIIMAGLVLFAI 90
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQG--MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLF 168
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGlgLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 1826022922 169 LLTSVLAVVGIIIVQFF 185
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-184 |
7.00e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 15 FSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIP-MGILSDKYGRKPIIMAGLVLFAIGSL 93
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 94 IAASSDHIYGVVFGRAVQGMGAIAAAVLALAAD--LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLT 171
Cdd:cd17330 257 LLPFASSVPLLVLAAAILAFGTGIVFPALSALLskSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
170
....*....|...
gi 1826022922 172 SVLAVVGIIIVQF 184
Cdd:cd17330 337 AGLLLIALFLLSL 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
219-374 |
8.04e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 8.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 219 AGIFILHLVLTAVFVALPLDLVDAGLVkekhwmlyFPAFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGlF 298
Cdd:COG2814 24 LGIGIVLPALPLIAADLGASPAQAGLV--------VTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA-L 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1826022922 299 ADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFVA 374
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
26-186 |
8.06e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 8.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALYGQHLEGFSP---LWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIY 102
Cdd:cd17391 215 LANQSIEPILTLYIRQLMGDASnlaFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPW 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 103 GVVFGRAVQGM--GAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGII 180
Cdd:cd17391 295 QLGILRFLLGLatGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
....*.
gi 1826022922 181 IVQFFV 186
Cdd:cd17391 375 WSFIFL 380
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
48-114 |
1.06e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 41.25 E-value: 1.06e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1826022922 48 LWVgiaIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMG 114
Cdd:PRK14995 44 LWI---IDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIG 107
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
26-114 |
1.67e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.70 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 26 MGLFMIMPVFALY---GQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLI-AASSDHI 101
Cdd:cd17356 20 ISGILNMKSFQKYfadNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKW 99
|
90
....*....|...
gi 1826022922 102 YGVVFGRAVQGMG 114
Cdd:cd17356 100 YQLIVGRIIAGLG 112
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-185 |
1.71e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 20 VFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSD 99
Cdd:cd17353 221 MFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 100 HIYGVVFGrAVQGMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSV----GLTGLFLLTSVLA 175
Cdd:cd17353 301 SVAVLFVL-GVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlytgGYNAAFIIAAALS 379
|
170
....*....|
gi 1826022922 176 VVGIIIVQFF 185
Cdd:cd17353 380 LVALALALLL 389
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
44-373 |
1.73e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.33 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVF----GRAVQGMGAIAAA 119
Cdd:cd17312 34 GLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVlwglNGLFQSMGWPPCV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 120 VLALAADLtrDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPisqapkgdtl 199
Cdd:cd17312 114 KLLGNWFS--KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 200 atpaklkkmlfDPQLFRLDAGIFILHLVLTAVFVALPLDLVDaglvkEKHWMLYFPAFIGAFFLMVPL---IIIG----- 271
Cdd:cd17312 182 -----------PPYVWVLSLAYAFVYIVRYACLDWGPLYLYE-----VKGYSLIDAGWFSSLYEVGGIagtILAGllsdk 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 272 VKKNNTKTMFQLSLLIMMAALAAMGLFADNLWVlsIAVVLFFTGF--NYLEASLPSLIAKFCPVGE-KGSAMGVYSTSQF 348
Cdd:cd17312 246 LFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLL--SIVLLFLIGFfvGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGY 323
|
330 340
....*....|....*....|....*
gi 1826022922 349 LGAFCGGMLGGGAYQLLGASGVFFV 373
Cdd:cd17312 324 LGASLAGLPLGYIIDHYGWSTVFYF 348
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
131-316 |
1.88e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 131 EQRTKVMAV-IGMCIGFSFALSLLVGPIVA------QSVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQAPKGDTLATPA 203
Cdd:cd17332 132 EERTSLTSWrMFFATIGGLLVTVLPPPLVAyfgggnASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 204 KLKKMLF-DPQLFRLDAGIFILHLVLTAVFVALPLDLVDAgLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTKTMFQ 282
Cdd:cd17332 212 KSLKALLkNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYV-LGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF 290
|
170 180 190
....*....|....*....|....*....|....*
gi 1826022922 283 LSLLIMMAALAAMGLF-ADNLWVLSIAVVLFFTGF 316
Cdd:cd17332 291 IGLLLAILGLLLLFFLpPGNLVLILVLAVLAGIGY 325
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
30-195 |
1.94e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYG------ 103
Cdd:PRK05122 33 LPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGLLAAwpvlsl 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 104 --VVFGRAVQGMGAIAAAVLALAADLTR--DEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGI 179
Cdd:PRK05122 113 llLLLGRLLLGIGESLAGTGSILWGIGRvgALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIMLLALLGL 192
|
170
....*....|....*.
gi 1826022922 180 IIVQFFVPNPISQAPK 195
Cdd:PRK05122 193 LLARPRPAVPPVKGER 208
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-114 |
2.09e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 2.09e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1826022922 68 MGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMG 114
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT 91
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
128-374 |
2.75e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.89 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 128 TRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQA--------PKGDTL 199
Cdd:cd17331 115 TDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKrekeakesASPPSV 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 200 ATPAKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDA-GLVKEKHWMLYFPAFIGAFFLMVPLIIIGVKKNNTK 278
Cdd:cd17331 195 FNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFfGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGER 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 279 TMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFnYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLG 358
Cdd:cd17331 275 SLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGS-VLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIG 353
|
250
....*....|....*.
gi 1826022922 359 GGAYQLLGASGVFFVA 374
Cdd:cd17331 354 GALLQAYGFPSFGLLG 369
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
69-373 |
2.86e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.88 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 69 GILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSF 148
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 149 --ALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVqffvpnpisqapkGDTLAtpaklkkmlfdpqlfrLDAGIFILHL 226
Cdd:cd17365 135 gaALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL-------------RGTLL----------------LWVTFFMGLL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 227 VLTAVFVALPLDLVDAGLVKEKHWMLYFPAFIGAfflMVPLIIIGV--KKNNTKTMFQLSLLIMMAALAAMGLFADNLWV 304
Cdd:cd17365 186 LVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGG---VIGSLLLGWlaDRFGPKRVLALFFALGAVSLALLGVSPASLVL 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 305 LSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQL-LGASGVFFV 373
Cdd:cd17365 263 LYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAgLGPESVFLA 332
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
44-366 |
2.97e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDK----YGR-KPIIMAGLVLFAIGSLIAASSDHIYG----VVFGRAVQGMG 114
Cdd:pfam13347 29 GLSAAAVGLVLLVARLVDAFTDPIVGHIIDRtrtrWGRrRPWLLLSAIILAVSFILLFTPPELGRaplfIWLLATYILLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 115 AIAAAV----LALAADLTRD-EQRTKVMAVIGMC-IGFSFALSLLVGPIVAQS-------VGLTGLFLLTSVLAVVGIII 181
Cdd:pfam13347 109 IAYTFFeipyWSLGPELTRDyDERTSLTSYRSFFsVGGGLLAAALAFPLVLILggtglerKGYRIFALIGAVLMLLGVII 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 182 VQFFVPNPISQAPKGDTLATPAK-----LKKMLFDPQLFRLdAGIFILHLVLTAVFVALpLDLVDAGLVKEKHWMLYFP- 255
Cdd:pfam13347 189 TAAGTKERVSMRSKEDTGQKEAGslldmLKEVFRNRAFLIL-LASFLLAALAMGVLNGL-LLYYFRYVLGNGFAASAFPl 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 256 AFIGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGLF-ADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVG 334
Cdd:pfam13347 267 VFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLgPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYG 346
|
330 340 350
....*....|....*....|....*....|....*....
gi 1826022922 335 E-------KGSAMGVYSTSQFLGAFCGGMLGGGAYQLLG 366
Cdd:pfam13347 347 ElrtgkrrEGTFFAMWSFISKLATGVGLGVSGLLLSAFG 385
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
20-90 |
3.65e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.43 E-value: 3.65e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1826022922 20 VFGLRMM--GLFMIMPVFAL-YGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAI 90
Cdd:cd17369 233 AIGLRLAenVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL 306
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
49-388 |
4.12e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.08 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 49 WVGIAigaYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGA--IAAAVLALAAD 126
Cdd:cd17502 34 WVGTA---YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGggLMSLAFIIIAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 127 LTRDEQRTKVMAVIGMcigfSFALSLLVGPIV----AQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQApkgdtLATP 202
Cdd:cd17502 111 LVPPRERGKYQGYIGA----VFGIASVAGPLIggafTDHLSWRWCFYINLPIGGLALALLRTILLSSIFGF-----LFGG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 203 AKLKKMLFDPQLFRL-------DAGIFILHLVLTAVFVALPLdlvdaglvkekhwmlyfPAFIGAFFLMVPLIIIGVkkn 275
Cdd:cd17502 182 ALFGLIYYLPLYFQLvlgdsatKSGVRLLPLIIGLVIGSIIS-----------------GALISKTGRYKPLIVIGT--- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 276 ntktmfqlSLLIMMAALAAMGLFADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGEKGSAMGVYSTSQFLGafcgg 355
Cdd:cd17502 242 --------ILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLG----- 308
|
330 340 350
....*....|....*....|....*....|....*
gi 1826022922 356 mlgggayQLLGAS--GVFFVALALMFLWLLLTFGM 388
Cdd:cd17502 309 -------GTLGVAitDVFLVALALAALAFLLSLFL 336
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-151 |
4.86e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 11 KKVAFSLASVFGLRMMGLFMIMPVFALYGQHLeGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAI 90
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQ-----GMGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALS 151
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALlllgfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-181 |
4.98e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 27 GLFMIMPVfalYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVF 106
Cdd:cd17316 195 GLTTFLPT---YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1826022922 107 GRAVQGMGAIAAAVLALAADLTRDEQRTKVMAV-IGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIII 181
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAELFPTEVRATgVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
44-371 |
5.45e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRA----VQGMGAIAAA 119
Cdd:TIGR00881 26 GLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAlngiFQGMGWPPCG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 120 VLALAADLTRdeQRTKVMAV--IGMCIGFSFaLSLLVGPIVAQSVGLTGLFLLTSVLA-VVGIIIVQFFVPNPIS----- 191
Cdd:TIGR00881 106 RTVTKWFSRS--ERGTWVSFwnCSHNVGGGL-LPPLVLFGIAELYSWHWVFIVPGIIAiIVSLICFLLLRDSPQScglpp 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 192 ------QAPKGDTLATP-------AKLKKMLFDPQLFRLDAGIFILHLVLTAVFVALPLDLVDA-GLVKEKHWMLYFPAF 257
Cdd:TIGR00881 183 aeempnEEPDGDAEKKEeeltkkqIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEkGFSKEKASWAFTLYE 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 258 IGAFF-LMVPLIIIGVKKNNTK---TMFQLSLLIMMAALAAMGLFADNLWVLSIAVVLFFtgFNYLEASLPSLIA-KFCP 332
Cdd:TIGR00881 263 LGGLVgTLLAGWLSDKLFNGRRgplAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGF--LVYGPQMLIGVIAsELAP 340
|
330 340 350
....*....|....*....|....*....|....*....
gi 1826022922 333 VGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGASGVF 371
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-181 |
6.04e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 6.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 12 KVAFSLASVFGLRMMGLFMIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKY-GRKPIIMAGLVLFAI 90
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 91 GSLIAASSDHIYGVVFGRAVQG--MGAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFAL-SLLVGPIVAQSVGLTGL 167
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGfgLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIgPLLAGFLLAATFGLTGA 362
|
170
....*....|....
gi 1826022922 168 FLLTSVLAVVGIII 181
Cdd:cd06174 363 FLVLAVLLLLAAIL 376
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
43-373 |
6.55e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.64 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 43 EGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGS---LIAASSDHIYGVVF-GRAVQGMGAIAA 118
Cdd:cd17337 27 LGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEvlfLAFGLPSHNYPLMLlTYGLRGFGYPLF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 119 AVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLvGPIVAQ----SVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQAP 194
Cdd:cd17337 107 AYSFLVWITYRTPAERLGSAVGWFWFAFTGGLPVL-GSYLASftipVIGEIGTLWLSLVFVALGGLIALFLVRDRTGEQP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 195 KGDTLATPAK-LKK----MLFDPQLFRldAGI--FILHLVLTAVFVALPLDLVDAGLVKEKHWM-LYFPAFIGAFFLMVP 266
Cdd:cd17337 186 LANPSEEPLKeLLSgitiLFRNPKIAI--GGIvrIINTLSQFGFPVFMPLYFTDTGGFSTSQWLqIWGIIFLVNIFFNLI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 267 LIIIGVKKNNTKTMFQLSLLIMMAALAAMG----LFADNLWVLSIAVVLF---FTGFNYLEASLPSLIAKfcpvgEKGSA 339
Cdd:cd17337 264 FGILGDKIGWRRTVRWFGGVGCAISTLLFYyvpqLFGHNYWAALIAAILFgigLAGFVPLSALMPSLAPE-----HKGAA 338
|
330 340 350
....*....|....*....|....*....|....
gi 1826022922 340 MGVYSTSQFLGAFCGGMLGGGAYQLLGASGVFFV 373
Cdd:cd17337 339 MSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWI 372
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
40-114 |
7.33e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.33e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1826022922 40 QHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMG 114
Cdd:cd17359 28 QTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
49-374 |
7.83e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 49 WVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIA---ASSDHIY--GVVFGRAVQGMGAIAAAVLAL 123
Cdd:COG2270 53 LWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAAlffVAPGGLWlgLLLFVLANIGFEGSLVFYNAF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 124 AADLTRDEQRTKV------MAVIGMCIGFSFALSLLVGP----IVAQSVGLTGLFLLTSVLAVVGIIIVQFFVPNPISQA 193
Cdd:COG2270 133 LPDIATPEEIGRVsglgwaLGYLGGVLLLLINLALFLKPeafgLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 194 PKGDTLATPA-------KLKKMLFDPQLFRLDAGIFILHLVLTAVFVAL-----------PLDLVDAGLVkekhwmLYFP 255
Cdd:COG2270 213 PAPPRGAVRAgfrelrrTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAgiyaagvlgfsTTELIVFGLL------VQIV 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 256 AFIGAFflmvpliIIGV--KKNNTKTMFQLSLLIMMAALAAMGLFADNL--WVLSIAVVLFFTGfnyLEASLPSLIAKFC 331
Cdd:COG2270 287 AALGAL-------LFGRldDRIGPKRVILVSLVIWIVVCLAAYFLTTALafWILGLLIGLVMGG---IQALSRSLLARLI 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1826022922 332 PVGEKGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGAS-------GVFFVA 374
Cdd:COG2270 357 PPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQrlgilslIVFFVI 406
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
258-367 |
8.53e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 38.25 E-value: 8.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 258 IGAFFLMVPLIIIGVKKNNTKTMFQLSLLIMMAALAAMGL--FADNLWVLSIAVVLFFTGFNYLEASLPSLIAKFCPVGE 335
Cdd:cd06176 270 GGTLLGMLLAGFLLSRRLGKKRTAALGCLLSALGFLLLALagLLGNPWLFRPGVFLLGLGNGLFTVGALTLMMDLTGEGT 349
|
90 100 110
....*....|....*....|....*....|..
gi 1826022922 336 KGSAMGVYSTSQFLGAFCGGMLGGGAYQLLGA 367
Cdd:cd06176 350 AGLFMGLWGAAQALARGLGTLLGGALRDLLRA 381
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|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
44-224 |
9.08e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 44 GFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLIAASSDHIYGVVFGRAVQGMGAIA--AAVL 121
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGewAAGA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 122 ALAADLTRDEQRTKVMAVI--GMCIGFSFA--LSLLVGPIVAQSVGLTGLFLLTSVLAVVgIIIVQFFVPNP--ISQAPK 195
Cdd:cd17371 110 ALMAEYVPARHRGKALGYVqsGWAVGWLLAtlLAALLFPLLPPEIAWRVLFLLGALPALL-VLFIRRFVKEPpqWQAARA 188
|
170 180
....*....|....*....|....*....
gi 1826022922 196 GDTLATPAKLKKMLFDPQLFRLDAGIFIL 224
Cdd:cd17371 189 ARRHFADRPSLRELFSPPLLRTTLLASLL 217
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
51-187 |
9.52e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 37.98 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 51 GIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLI--AASSDHIYGVVFGRAVQGM--GAIAAAVLALAAD 126
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLaqGVTFPAMHALWAK 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1826022922 127 LTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFFVP 187
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
30-187 |
9.81e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 30 MIMPVFALYGQHLEGFSPLWVGIAIGAYGLTQAILQIPMGILSDKYGRKPIIMAGLVLFAIGSLI--AASSDHIYGVVFG 107
Cdd:cd17380 16 VNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826022922 108 RAVQGM--GAIAAAVLALAADLTRDEQRTKVMAVIGMCIGFSFALSLLVGPIVAQSVGLTGLFLLTSVLAVVGIIIVQFF 185
Cdd:cd17380 96 RILLGLgeGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIY 175
|
..
gi 1826022922 186 VP 187
Cdd:cd17380 176 LP 177
|
|
| |
