|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
1-591 |
0e+00 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 1110.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 1 MTIQKPNLPLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMM 80
Cdd:PRK14491 3 PFTNPLSIPLLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKHAHHNFDVDQPGKDSYRLRKAGASQMLVASRVRWALM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 81 AETP-DSEADFEYLLTRFDSEQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIA-ADSKVSSPLPQMDINDL 158
Cdd:PRK14491 83 TETPrDGEPELPHLLKQIDADKVDIVLVEGFKKLALPKIELHRAAHGKPWIYPHDENIIAIAcDDTPLPSELPRLDINDV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 159 NAIRDFILDYVTTYASNKSNQPVA--ACCDTLSPAFVSVTQGREKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVP 236
Cdd:PRK14491 163 AAIADFVLEYAQNWQAPAQDLPLApaCCCDLLSPAFLSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPVNVP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 237 QYTNSAMDGYAIRGDDLDQDNYHVVAEVLAGYHYEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKA 316
Cdd:PRK14491 243 QHTNSAMDGYAFRSDDLEPESYTLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 317 GQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGL 396
Cdd:PRK14491 323 GQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAM 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 397 LQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDK 476
Cdd:PRK14491 403 AKKLGCEVIDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGDS 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 477 PFFGLPGNPVAVMVSFINFVEPAIRKMQGQMDWQPLKVNAIAAESLRSRQGRTEFSRGVYTMNTQGQLEVRTTGKQGSGI 556
Cdd:PRK14491 483 PFFGLPGNPVAVMVSFLQFVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQGSGI 562
|
570 580 590
....*....|....*....|....*....|....*
gi 1809098606 557 LRSMSEANCLIEISPAVDTVKVGEMVTVIPLQGRV 591
Cdd:PRK14491 563 LSSMSEANCLIEIGPAAETVNAGETVTIQPLAGLL 597
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
193-590 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 535.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 193 VSVTQGREKILEAVSRLqETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDN---YHVVAEVLAGYH 269
Cdd:COG0303 2 ISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpvtLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 270 YEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLA 349
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 350 SLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQAD 429
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 430 LVMTSGGVSVGDADYIKLALDRLG-QIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQGQMD 508
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 509 WQPLKVNAIAAESLRSRQGRTEFSRGVYTmNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIPLQ 588
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLE-RDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
..
gi 1809098606 589 GR 590
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
199-587 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 530.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 199 REKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDN--YHVVAEVLAGYHYEKPVEP 276
Cdd:cd00887 4 ARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASvtLRVVGEIPAGEPPDGPLGP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 277 GQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLGFGQC 356
Cdd:cd00887 84 GEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 357 DVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGG 436
Cdd:cd00887 164 PVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 437 VSVGDADYIKLALDRL-GQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQGQMDWQPLKVN 515
Cdd:cd00887 244 VSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRVK 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1809098606 516 AIAAESLRSRQGRTEFSRGVYTmNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIPL 587
Cdd:cd00887 324 ARLAEDLKSKPGRREFLRVRLE-RDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| MobB |
pfam03205 |
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop. |
10-143 |
1.04e-63 |
|
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
Pssm-ID: 427196 [Multi-domain] Cd Length: 133 Bit Score: 205.48 E-value: 1.04e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 10 LLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDS-EA 88
Cdd:pfam03205 1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDIDKPGKDSWRHRKAGASEVLVASPGRWALMHELRDEpEP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1809098606 89 DFEYLLTRFDseQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIAAD 143
Cdd:pfam03205 81 SLEELLARLS--PVDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDPDIIAVASD 133
|
|
| mobB |
TIGR00176 |
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ... |
10-166 |
6.48e-48 |
|
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]
Pssm-ID: 272943 [Multi-domain] Cd Length: 155 Bit Score: 164.47 E-value: 6.48e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 10 LLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDsEAD 89
Cdd:TIGR00176 1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHETQE-ERD 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1809098606 90 FEYLLTRFDSeqLDVILVEGCKNIAFPKIELHREEVGKPwlYPNDDNIIAIAADSKVSSP-LPQMDINDLNAIRDFIL 166
Cdd:TIGR00176 80 LEALLDRLPD--LDIILVEGFKDSPLPKIVVFRNPAEES--EIIRPKIIAIASDESLSALkLPVLDLNDVEAIAAFIE 153
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
365-495 |
6.50e-36 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 131.17 E-value: 6.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 365 AIFSTGDEVQNPGaeqkpnTIYDSNRFTLRGLLQKLGCEIIDLGII--EDDEDKMVSALESAATQADLVMTSGGVSVGDA 442
Cdd:smart00852 1 AIISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1809098606 443 DYIKLALDRLG--QIDFWRINMRPGRPLAF---------GKINDKPFFGLPGNPVAVMVSFINF 495
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
1-591 |
0e+00 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 1110.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 1 MTIQKPNLPLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMM 80
Cdd:PRK14491 3 PFTNPLSIPLLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKHAHHNFDVDQPGKDSYRLRKAGASQMLVASRVRWALM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 81 AETP-DSEADFEYLLTRFDSEQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIA-ADSKVSSPLPQMDINDL 158
Cdd:PRK14491 83 TETPrDGEPELPHLLKQIDADKVDIVLVEGFKKLALPKIELHRAAHGKPWIYPHDENIIAIAcDDTPLPSELPRLDINDV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 159 NAIRDFILDYVTTYASNKSNQPVA--ACCDTLSPAFVSVTQGREKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVP 236
Cdd:PRK14491 163 AAIADFVLEYAQNWQAPAQDLPLApaCCCDLLSPAFLSVSQGLDKILSLVTPVTETEDVALDELDGRVLAQDVISPVNVP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 237 QYTNSAMDGYAIRGDDLDQDNYHVVAEVLAGYHYEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKA 316
Cdd:PRK14491 243 QHTNSAMDGYAFRSDDLEPESYTLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 317 GQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGL 396
Cdd:PRK14491 323 GQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAM 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 397 LQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDK 476
Cdd:PRK14491 403 AKKLGCEVIDLGIIEDSEAALEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGDS 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 477 PFFGLPGNPVAVMVSFINFVEPAIRKMQGQMDWQPLKVNAIAAESLRSRQGRTEFSRGVYTMNTQGQLEVRTTGKQGSGI 556
Cdd:PRK14491 483 PFFGLPGNPVAVMVSFLQFVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQGSGI 562
|
570 580 590
....*....|....*....|....*....|....*
gi 1809098606 557 LRSMSEANCLIEISPAVDTVKVGEMVTVIPLQGRV 591
Cdd:PRK14491 563 LSSMSEANCLIEIGPAAETVNAGETVTIQPLAGLL 597
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
193-590 |
0e+00 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 535.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 193 VSVTQGREKILEAVSRLqETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDN---YHVVAEVLAGYH 269
Cdd:COG0303 2 ISVEEALALILAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpvtLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 270 YEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLA 349
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 350 SLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQAD 429
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 430 LVMTSGGVSVGDADYIKLALDRLG-QIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQGQMD 508
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 509 WQPLKVNAIAAESLRSRQGRTEFSRGVYTmNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIPLQ 588
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLE-RDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
..
gi 1809098606 589 GR 590
Cdd:COG0303 400 GL 401
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
199-587 |
0e+00 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 530.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 199 REKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDN--YHVVAEVLAGYHYEKPVEP 276
Cdd:cd00887 4 ARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASvtLRVVGEIPAGEPPDGPLGP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 277 GQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLGFGQC 356
Cdd:cd00887 84 GEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIAEV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 357 DVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGG 436
Cdd:cd00887 164 PVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVITSGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 437 VSVGDADYIKLALDRL-GQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQGQMDWQPLKVN 515
Cdd:cd00887 244 VSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPRVK 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1809098606 516 AIAAESLRSRQGRTEFSRGVYTmNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIPL 587
Cdd:cd00887 324 ARLAEDLKSKPGRREFLRVRLE-RDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
193-586 |
8.75e-151 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 439.91 E-value: 8.75e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 193 VSVTQGREKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDNYHVVA-EVLAG--YH 269
Cdd:PRK10680 8 MSLETALTEMLSRVTPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQPLPVAgKAFAGqpFH 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 270 YEKPVepGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLA 349
Cdd:PRK10680 88 GEWPA--GTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAELPVLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 350 SLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQAD 429
Cdd:PRK10680 166 SLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIEADSQAD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 430 LVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQGQMDW 509
Cdd:PRK10680 246 VVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSGNTAS 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1809098606 510 Q-PLKVNAIAAESLRSRQGRTEFSRGVYTMNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIP 586
Cdd:PRK10680 326 GlPPRQRVRTASRLKKTPGRLDFQRGILQRNADGELEVTTTGHQGSHIFSSFSLGNCFIVLERERGNVEVGEWVEVEP 403
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
193-584 |
2.63e-105 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 330.64 E-value: 2.63e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 193 VSVTQGREKILEAVSRLQ-ETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDL---DQDN---YHVVAEVL 265
Cdd:PRK14498 10 VSLEEAREILESLLSELPlGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTfgaSEANpvrLKLGGEVH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 266 AGYHYEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEG-DSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPE 344
Cdd:PRK14498 90 AGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAGELILPKGTRLTPRD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 345 MGMLASLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESA 424
Cdd:PRK14498 170 IGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRKA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 425 ATQADLVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQ 504
Cdd:PRK14498 250 LKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 505 GQMDWQPLKVNAIAAESLRSRQGRTEFSRGVYTMNTQGqLEVRTTGKqGSGILRSMSEANCLIEISPAVDTVKVGEMVTV 584
Cdd:PRK14498 330 GLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDG-YVAYPLSR-GSGAITSLVRADGFIEIPANTEGLEAGEEVEV 407
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
180-586 |
1.33e-79 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 257.15 E-value: 1.33e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 180 PVAACCDTLSPA--FVSVTQGREKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDldQDN 257
Cdd:PRK14690 8 PLKNDCFALPPGvdWTPVDTALDLLRARLGPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAA--PEG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 258 YHVV----AEVLAGYHYEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIKAGQNVRQAGEDLALGAPV 333
Cdd:PRK14690 86 AQVLplieGRAAAGVPFSGRVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 334 FTQGTRIESPEMGMLASLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDD 413
Cdd:PRK14690 166 LPAGRRLTPADLALLSAVGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 414 EDKMVSALESAATQADLVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFI 493
Cdd:PRK14690 246 RAALAARLDRAAAEADVILTSGGASAGDEDHVSALLREAGAMQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 494 NFVEPAIRKMQGQMDWQPLKVNAIAAESLRSRQGRTEFSRGVYtmnTQGQLEVRTTgkQGSGILRSMSEANCLIEISPAV 573
Cdd:PRK14690 326 VFARPAMSLLAGEGWSEPQGFTVPAAFEKRKKPGRREYLRARL---RQGHAEVFRS--EGSGRISGLSWAEGLVELGDGA 400
|
410
....*....|...
gi 1809098606 574 DTVKVGEMVTVIP 586
Cdd:PRK14690 401 RRIAPGDPVRFIP 413
|
|
| MobB |
COG1763 |
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ... |
9-169 |
1.32e-78 |
|
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 441369 [Multi-domain] Cd Length: 162 Bit Score: 245.09 E-value: 1.32e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 9 PLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDsEA 88
Cdd:COG1763 2 PVLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHDFDIDTPGKDSYRHREAGADEVLVASPERWALMTELPE-EP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 89 DFEYLLTRFDseQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIAADSKVSSPLPQMDINDLNAIRDFILDY 168
Cdd:COG1763 81 SLDELLARLD--DVDLVLVEGFKHEPLPKIEVHRAEEGKPLLYPEDPNIIAVASDAPLPTGLPVFDLNDPEAIADFILEW 158
|
.
gi 1809098606 169 V 169
Cdd:COG1763 159 L 159
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
189-585 |
2.18e-73 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 247.42 E-value: 2.18e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 189 SPAFVSVTQGREKILEAVSRLQETEaVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDQDnYHVVAEVLAG- 267
Cdd:PLN02699 4 KTEMISVEEALSIVLSVAARLSPVI-VPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGPGE-YPVITESRAGn 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 268 YHYEKPVEPGQAVKIMTGAPMPAQADTVIMREQATQEGDSVTFDASIK------AGQNVRQAGEDLALGAPVFTQGTRIE 341
Cdd:PLN02699 82 DGLGVTLTPGTVAYVTTGGPIPDGADAVVQVEDTEVVEDPLDGSKRVRilsqasKGQDIRPVGCDIEKDAKVLKAGERLG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 342 SPEMGMLASLGFGQCDVVRKLKVAIFSTGDEVQNPGAEQ-KPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSA 420
Cdd:PLN02699 162 ASEIGLLATVGVTMVKVYPRPTVAILSTGDELVEPTTGTlGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 421 LESA-ATQADLVMTSGGVSVGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDKP---------FFGLPGNPVAVMV 490
Cdd:PLN02699 242 LDEAiSSGVDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIDAKSapsnskkmlAFGLPGNPVSCLV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 491 SFINFVEPAIRKMQGQMDWQPLKVNAIAAESLRSRQGRTEFSRGV--YTMNT---QGQLEVRTTGKQGSGILRSMSEANC 565
Cdd:PLN02699 322 CFNLFVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVRPEFHRAIirWKLNDgsgNPGFVAESTGHQMSSRLLSMKSANA 401
|
410 420
....*....|....*....|
gi 1809098606 566 LIEISPAVDTVKVGEMVTVI 585
Cdd:PLN02699 402 LLELPATGNVLSAGTSVSAI 421
|
|
| PRK10751 |
PRK10751 |
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional |
5-171 |
1.07e-69 |
|
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
Pssm-ID: 236750 [Multi-domain] Cd Length: 173 Bit Score: 222.65 E-value: 1.07e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 5 KPNLPLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETP 84
Cdd:PRK10751 3 KTMIPLLAIAAWSGTGKTTLLKKLIPALCARGIRPGLIKHTHHDMDVDKPGKDSYELRKAGAAQTLVASQQRWALMTETP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 85 DSEA-DFEYLLTRFDSEQLDVILVEGCKNIAFPKIELHREEVGKPW--LYPnDDNIIAIAADSKVSSPLPQMDINDLNAI 161
Cdd:PRK10751 83 DQEElDLHYLASRMDASKLDLILVEGFKHEPIAKIALFRDGAGHRPeeLVI-DEHVIAVASDVPLNLDVPLLDINDVEQI 161
|
170
....*....|
gi 1809098606 162 RDFILDYVTT 171
Cdd:PRK10751 162 ADFIVEWLQK 171
|
|
| MobB |
pfam03205 |
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop. |
10-143 |
1.04e-63 |
|
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
Pssm-ID: 427196 [Multi-domain] Cd Length: 133 Bit Score: 205.48 E-value: 1.04e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 10 LLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDS-EA 88
Cdd:pfam03205 1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHGFDIDKPGKDSWRHRKAGASEVLVASPGRWALMHELRDEpEP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1809098606 89 DFEYLLTRFDseQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIAAD 143
Cdd:pfam03205 81 SLEELLARLS--PVDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDPDIIAVASD 133
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
200-505 |
2.54e-62 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 215.06 E-value: 2.54e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 200 EKILEAVSRLQETEAVAITNSYGRVLGGDIISPVNVPQYTNSAMDGYAIRgDDLDQDNYHVVAEVLAGYHYEKPVEPGQA 279
Cdd:PRK14497 18 KVFLSSLNFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALK-SSCTPGEFKVIDKIGIGEFKEIHIKECEA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 280 VKIMTGAPMPAQADTVIMREQA-TQEGDSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLGFGQCDV 358
Cdd:PRK14497 97 VEVDTGSMIPMGADAVIKVENTkVINGNFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIGLLASLGISSVKV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 359 VRKLKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVS 438
Cdd:PRK14497 177 YEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISVADVLILTGGTS 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1809098606 439 VGDADYIKLALDRLGQIDFWRINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAIRKMQG 505
Cdd:PRK14497 257 AGEKDFVHQAIRELGNIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLKSLYP 323
|
|
| MobB |
cd03116 |
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ... |
9-166 |
5.97e-59 |
|
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.
Pssm-ID: 349770 [Multi-domain] Cd Length: 157 Bit Score: 193.62 E-value: 5.97e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 9 PLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDSEA 88
Cdd:cd03116 1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGFDIDTPGKDSYRHRQAGADAVLVSSPNRLALIHERPEWEL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1809098606 89 DFEYLLTRFdsEQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIAADSKVS-SPLPQMDINDLNAIRDFIL 166
Cdd:cd03116 81 TLLELLARF--SDVDLVLVEGFKKEPIPKIEVFREEEGKPLLLPEDPNVIAVATDEPLDmLGLPVFDLNDVEEIADFIL 157
|
|
| PRK14489 |
PRK14489 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; ... |
7-167 |
8.02e-49 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional
Pssm-ID: 237727 [Multi-domain] Cd Length: 366 Bit Score: 173.78 E-value: 8.02e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 7 NLPLLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDS 86
Cdd:PRK14489 204 APPLLGVVGYSGTGKTTLLEKLIPELIARGYRIGLIKHSHHRVDIDKPGKDSHRLRAAGANPTMIVCPERWALMRETPEE 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 87 EADFEYLLTRFDSEQLDVILVEGCKNIAFPKIELHREEVGKPwLYPNDDNIIAIAADSKVSSPlPQMDINDLNAIRDFIL 166
Cdd:PRK14489 284 AVPFKVLIATFDPEEVDLILVEGFKHEPLPKIQLHRQLISKP-LPELDLWTIATATDYPLARD-PRLDINDVKQIADFVR 361
|
.
gi 1809098606 167 D 167
Cdd:PRK14489 362 Q 362
|
|
| mobB |
TIGR00176 |
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ... |
10-166 |
6.48e-48 |
|
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]
Pssm-ID: 272943 [Multi-domain] Cd Length: 155 Bit Score: 164.47 E-value: 6.48e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 10 LLGFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDsEAD 89
Cdd:TIGR00176 1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHDHHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHETQE-ERD 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1809098606 90 FEYLLTRFDSeqLDVILVEGCKNIAFPKIELHREEVGKPwlYPNDDNIIAIAADSKVSSP-LPQMDINDLNAIRDFIL 166
Cdd:TIGR00176 80 LEALLDRLPD--LDIILVEGFKDSPLPKIVVFRNPAEES--EIIRPKIIAIASDESLSALkLPVLDLNDVEAIAAFIE 153
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
209-352 |
1.07e-45 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 158.11 E-value: 1.07e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 209 LQETEAVAIT--NSYGRVLGGDIISPVNVPQYTNSAMDGYAIRGDDLDqdNYHVVAEVLAGYHYEKPVEPGQAVKIMTGA 286
Cdd:pfam03453 3 LGTEETVPLEalDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGF--GASEVNPIAAGEPPGPLLPGGEAVRIMTGA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1809098606 287 PMPAQADTVIMREQATQEG-DSVTFDASIKAGQNVRQAGEDLALGAPVFTQGTRIESPEMGMLASLG 352
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGgRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
362-498 |
5.88e-39 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 139.76 E-value: 5.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 362 LKVAIFSTGDEVQNPGAEQKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVSVGD 441
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1809098606 442 ADYIKLALDRLGQIDFW-----------RINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEP 498
Cdd:TIGR00177 81 RDVTPEALEELGEKEIPgfgefrmlsslPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
365-495 |
6.50e-36 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 131.17 E-value: 6.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 365 AIFSTGDEVQNPGaeqkpnTIYDSNRFTLRGLLQKLGCEIIDLGII--EDDEDKMVSALESAATQADLVMTSGGVSVGDA 442
Cdd:smart00852 1 AIISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1809098606 443 DYIKLALDRLG--QIDFWRINMRPGRPLAF---------GKINDKPFFGLPGNPVAVMVSFINF 495
Cdd:smart00852 75 DLTPEALAELGgrELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
363-500 |
3.90e-35 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 129.00 E-value: 3.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 363 KVAIFSTGDEVQNpgaeqkpNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVSVGDA 442
Cdd:cd00758 1 RVAIVTVSDELSQ-------GQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRR 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 443 DYIKLALDRLGQIDFW--RINMRPGRPLAFGKINDKPFFGLPGNPVAVMVSFINFVEPAI 500
Cdd:cd00758 74 DVTPEALAELGEREAHgkGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
365-502 |
6.10e-34 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 125.82 E-value: 6.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 365 AIFSTGDEVqnpgaeqKPNTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGGVSVGDADY 444
Cdd:pfam00994 1 AIITTGDEL-------LPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDV 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 445 IKLALDRLGQ-------IDFWRINMRPGRPLAFGKI-----NDKPFFGLPGNPVAVMVSFINFVEPAIRK 502
Cdd:pfam00994 74 TPEALAELGGrelpgfeELFRGVSLKPGKPVGTAPGailsrAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| PRK14490 |
PRK14490 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; ... |
11-165 |
1.19e-26 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional
Pssm-ID: 237728 [Multi-domain] Cd Length: 369 Bit Score: 111.68 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 11 LGFAAYSGTGKTTLLEALLPKLTETgLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDSEadf 90
Cdd:PRK14490 8 IAFCGYSGSGKTTLITALVRRLSER-FSVGYYKHGCHRFDIDREGKDSDLARKAGASTVMISDPEKHALIAGGPPDP--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 91 eyLLTRFDSEQLDVILVEGCKNIAFPKIEL--HREEVGKPWLYPNDDNIIAIAA-DSKVSSP---LPQMDINDLNAIRDF 164
Cdd:PRK14490 84 --LLERGAFLDCDLLLVEGLKELPLPKILLvdRERKILDLLEQGSVTNVVALVVpDDPASYPdfgLPVFHRDDIAAIADF 161
|
.
gi 1809098606 165 I 165
Cdd:PRK14490 162 I 162
|
|
| PRK14495 |
PRK14495 |
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion ... |
12-166 |
3.81e-24 |
|
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional
Pssm-ID: 172967 Cd Length: 452 Bit Score: 105.53 E-value: 3.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 12 GFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFDVDKPGKDSYRLRKAGASQMLISSRYRHAMMAETPDSEADFE 91
Cdd:PRK14495 5 GIIGWKDAGKTGLVERLVAAIAARGFSVSTVKHSHHDVDPDPPGSDSHRHRAAGAAEVVLAGPRRLILTREHRGEPPRLA 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1809098606 92 YLLTRFdsEQLDVILVEGCKNIAFPKIELHREEVGKPWLYPNDDNIIAIAADSKVSSPLPQMDINDLNAIRDFIL 166
Cdd:PRK14495 85 AILERM--APVDLVLVEGYKTEPHPKIEVFRKAAGHALRQPEDPWVRAVASDTQMALPVPVLDLDDTEAVADFLL 157
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
515-587 |
3.69e-19 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 81.89 E-value: 3.69e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1809098606 515 NAIAAESLRSRQGRTEFSRGVYTmNTQGQLEVRTTGKQGSGILRSMSEANCLIEISPAVDTVKVGEMVTVIPL 587
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLH-EEDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| PRK14494 |
PRK14494 |
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ... |
12-168 |
2.41e-17 |
|
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional
Pssm-ID: 237731 [Multi-domain] Cd Length: 229 Bit Score: 81.56 E-value: 2.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 12 GFAAYSGTGKTTLLEALLPKLTETGLRIGVLKHAHHNFdvDKPGKDSYRLRKAGASQMLISSR-----YRHAMmaetpds 86
Cdd:PRK14494 5 GVIGFKDSGKTTLIEKILKNLKERGYRVATAKHTHHEF--DKPDTDTYRFKKAGAEVVVVSTDetaafLYDRM------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 87 eaDFEYLLTRFDseqLDVILVEGCKNIA-FPKIELHREEVGKPWLypndDNIIAIAADSKVSSPLPQMDINDLNAIRDFI 165
Cdd:PRK14494 76 --DLNEILSLLD---ADFLLIEGFKELLnIPKILCLRDAEGVELL----DDGTALAIDDFKYGTEEIDELADLVLERAFV 146
|
...
gi 1809098606 166 LDY 168
Cdd:PRK14494 147 LPY 149
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
359-483 |
1.46e-08 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 56.40 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 359 VRKLKVAIFSTGDEVQNPGAEQKPNTIydsnrftLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQ-ADLVMTSGGV 437
Cdd:cd03522 157 FRPLRVGLIVTGSEVYGGRIEDKFGPV-------LRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAgAELLILTGGA 229
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1809098606 438 SVGDADYIKLALDRLG-QIDfwRINM--RPGRPLAFGKINDKPFFGLPG 483
Cdd:cd03522 230 SVDPDDVTPAAIRAAGgEVI--RYGMpvDPGNLLLLGYLGGVPVIGLPG 276
|
|
| PRK14493 |
PRK14493 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ... |
11-120 |
1.63e-06 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional
Pssm-ID: 237730 [Multi-domain] Cd Length: 274 Bit Score: 50.00 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 11 LGFAAYSGTGKTTLLEALLPKLTETGlRIGVLKHAHHNFDVDkPGKDSYRLRKAGASQMLISSRYRHAMMAETPDSEADF 90
Cdd:PRK14493 4 LSIVGYKATGKTTLVERLVDRLSGRG-RVGTVKHMDTERLNP-DGTDTGRHFDAGADVVYGLTDGEWVASGRDRSLDDAL 81
|
90 100 110
....*....|....*....|....*....|
gi 1809098606 91 EYLltrfdSEQLDVILVEGCKNIAFPKIEL 120
Cdd:PRK14493 82 DDL-----APGMDYAVVEGFKDSRLPKVVL 106
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
363-436 |
3.09e-04 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 41.70 E-value: 3.09e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1809098606 363 KVAIFSTGDEVQNPgaeqkpnTIYDSNRFTLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAATQADLVMTSGG 436
Cdd:cd00885 1 TAEIIAIGDELLSG-------QIVDTNAAFLAKELAELGIEVYRVTVVGDDEDRIAEALRRASERADLVITTGG 67
|
|
| MoaB |
COG0521 |
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ... |
392-488 |
1.89e-03 |
|
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440287 [Multi-domain] Cd Length: 169 Bit Score: 39.33 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 392 TLRGLLQKLGCEIIDLGIIEDDEDKMVSALESAAT--QADLVMTSGGVSVGDADY----IKLALDR----LGQIdFWRIN 461
Cdd:COG0521 33 ALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDdeGVDLVLTTGGTGLSPRDVtpeaTRPLLDKelpgFGEL-FRALS 111
|
90 100 110
....*....|....*....|....*....|...
gi 1809098606 462 MRPGRPLAF------GKINDKPFFGLPGNPVAV 488
Cdd:COG0521 112 LEEIGPSAIlsravaGIRGGTLIFNLPGSPGAV 144
|
|
| MogA_MoaB |
cd00886 |
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ... |
393-500 |
2.49e-03 |
|
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.
Pssm-ID: 238451 [Multi-domain] Cd Length: 152 Bit Score: 38.61 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809098606 393 LRGLLQKLGCEIIDLGIIEDDEDKMVSALESAA--TQADLVMTSG--GVSVGD--ADYIKLALDR----LGQIdFWRINM 462
Cdd:cd00886 25 LVELLEEAGHEVVAYEIVPDDKDEIREALIEWAdeDGVDLILTTGgtGLAPRDvtPEATRPLLDKelpgFGEA-FRALSL 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1809098606 463 RPG------RPLAfGKINDKPFFGLPGNPVAVMVSfINFVEPAI 500
Cdd:cd00886 104 EETgtamlsRAVA-GIRGGTLIFNLPGSPKAVREA-LEVILPEL 145
|
|
| |
