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Conserved domains on  [gi|1801978541|gb|QHO71163|]
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hypothetical protein BHD05_11775 [Marisediminicola antarctica]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-215 7.84e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 99.78  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   1 MTVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAA 80
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  81 SGEFLIRLDADDLLTPGSVARSVALAEKHPqVGMVYGYPVpfsgsapesHRDRAKFWDIWSGASWLERRCQLGVNCITSP 160
Cdd:COG0463    82 RGDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRL---------IREGESDLRRLGSRLFNLVRLLTNLPDSTSG 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1801978541 161 EVLMRASVVDSVGGQRALAhtHDMEMWFRLARYSDVGWVggcdQALHRDHPDSLS 215
Cdd:COG0463   152 FRLFRREVLEELGFDEGFL--EDTELLRALRHGFRIAEV----PVRYRAGESKLN 200
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-215 7.84e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 99.78  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   1 MTVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAA 80
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  81 SGEFLIRLDADDLLTPGSVARSVALAEKHPqVGMVYGYPVpfsgsapesHRDRAKFWDIWSGASWLERRCQLGVNCITSP 160
Cdd:COG0463    82 RGDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRL---------IREGESDLRRLGSRLFNLVRLLTNLPDSTSG 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1801978541 161 EVLMRASVVDSVGGQRALAhtHDMEMWFRLARYSDVGWVggcdQALHRDHPDSLS 215
Cdd:COG0463   152 FRLFRREVLEELGFDEGFL--EDTELLRALRHGFRIAEV----PVRYRAGESKLN 200
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-117 2.58e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 80.63  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   5 VIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAASGEF 84
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1801978541  85 LIRLDADDLLTPGSVARSVALAEKHPQVGMVYG 117
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-156 4.68e-18

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 80.13  E-value: 4.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   4 TVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAASGE 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1801978541  84 FLIRLDADDLLTPGSVARSVALAEKHPQVGMVYGYPVPFSGSAPESHRDRAKFWDIWSGASWLERRCQLGVNC 156
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-108 5.68e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.59  E-value: 5.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   3 VTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIaHPHNLGPVAAFNDGLAAASG 82
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLL-HQANAGVSVARNTGLAVATG 86

                          90       100
                  ....*....|....*....|....*.
gi 1801978541  83 EFLIRLDADDLLTPGSVARSVALAEK 108
Cdd:PRK10073   87 KYVAFPDADDVVYPTMYETLMTMALE 112
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-215 7.84e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 99.78  E-value: 7.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   1 MTVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAA 80
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  81 SGEFLIRLDADDLLTPGSVARSVALAEKHPqVGMVYGYPVpfsgsapesHRDRAKFWDIWSGASWLERRCQLGVNCITSP 160
Cdd:COG0463    82 RGDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRL---------IREGESDLRRLGSRLFNLVRLLTNLPDSTSG 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1801978541 161 EVLMRASVVDSVGGQRALAhtHDMEMWFRLARYSDVGWVggcdQALHRDHPDSLS 215
Cdd:COG0463   152 FRLFRREVLEELGFDEGFL--EDTELLRALRHGFRIAEV----PVRYRAGESKLN 200
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-117 2.58e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 80.63  E-value: 2.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   5 VIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAASGEF 84
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1801978541  85 LIRLDADDLLTPGSVARSVALAEKHPQVGMVYG 117
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVGG 113
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-156 4.68e-18

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 80.13  E-value: 4.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   4 TVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAASGE 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1801978541  84 FLIRLDADDLLTPGSVARSVALAEKHPQVGMVYGYPVPFSGSAPESHRDRAKFWDIWSGASWLERRCQLGVNC 156
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-192 1.90e-14

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 72.85  E-value: 1.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   1 MTVTVIIPCFNYARFLPGAIASALDQRDVDIDVI--VVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLA 78
Cdd:COG1215    29 PRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEviVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGLK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  79 AASGEFLIRLDADDLLTPGSVARSVALAEkHPQVGMvygypvpfsgsapeshrdrakfwdiwSGASwlerrcqlgvncit 158
Cdd:COG1215   109 AARGDIVVFLDADTVLDPDWLRRLVAAFA-DPGVGA--------------------------SGAN-------------- 147

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1801978541 159 speVLMRASVVDSVGGQRALAHTHDMEMWFRLAR 192
Cdd:COG1215   148 ---LAFRREALEEVGGFDEDTLGEDLDLSLRLLR 178
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-192 2.63e-14

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 70.65  E-value: 2.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   4 TVIIPCFNYARFLPGAIASALDQRdvdidvivvddsSSD------------GSLAVARRIAHDDARvqVIAHPHNlGPVA 71
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQT------------YPNieyividggstdGTVDIIKKYEDKITY--WISEPDK-GIYD 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  72 AFNDGLAAASGEFLIRLDADDLLTPGSVARSVALAEKHPQVGMVYGYPVPFSgsaPESHRDRAKFWDIWSGASWLERrcq 151
Cdd:cd06433    66 AMNKGIALATGDIIGFLNSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVD---ENGRVIGRRRPPPFLDKFLLYG--- 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1801978541 152 lgvNCITSPEVLMRASVVDSVGGQRALAHTH-DMEMWFRLAR 192
Cdd:cd06433   140 ---MPICHQATFFRRSLFEKYGGFDESYRIAaDYDLLLRLLL 178
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-106 2.20e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 65.01  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   1 MTVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDdaRVQVIAHPHNLGPVAAFNDGLAAA 80
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFP--RVRVIRNPENLGFAAARNLGLRAA 80

                          90       100
                  ....*....|....*....|....*.
gi 1801978541  81 SGEFLIRLDADDLLTPGSVARSVALA 106
Cdd:COG1216    81 GGDYLLFLDDDTVVEPDWLERLLAAA 106
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 2-192 5.80e-12

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 64.31  E-value: 5.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   2 TVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIA--HDDARVQVIAHPHNLGP---VAAFNDG 76
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAarFPDVRLRVIRNARLLGPtgkSRGLNHG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  77 LAAASGEFLIRLDADDLLTPGSVARSVALAeKHPQVGMVYGypVPF----SGSAPESHRDRAKFWDIWSGASWLErrcqL 152
Cdd:pfam13641  83 FRAVKSDLVVLHDDDSVLHPGTLKKYVQYF-DSPKVGAVGT--PVFslnrSTMLSALGALEFALRHLRMMSLRLA----L 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1801978541 153 GVNCITSPEVLMRASVVDSVGG-QRALAHTHDMEMWFRLAR 192
Cdd:pfam13641 156 GVLPLSGAGSAIRREVLKELGLfDPFFLLGDDKSLGRRLRR 196
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 47-116 6.08e-12

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 63.76  E-value: 6.08e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  47 VARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAASGEFLIRLDADDLLTPGSVARSVALAEKHPQVGMVY 116
Cdd:cd04184    49 VLKKYAAQDPRIKVVFREENGGISAATNSALELATGEFVALLDHDDELAPHALYEVVKALNEHPDADLIY 118
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 58-190 2.95e-09

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 56.17  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  58 VQVIAHPHNLGPVAAFNDGLAAASGEFLIRLDADDLLTPGSVARSVALAEKHPQVGMVYGYPVPFSGS--------APES 129
Cdd:cd04195    57 LKVVPLEKNRGLGKALNEGLKHCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDgndigkrrLPTS 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1801978541 130 HRDRAKFwdiwsgaswLERRCQLgvnciTSPEVLMRASVVDSVGGQRALAHTHDMEMWFRL 190
Cdd:cd04195   137 HDDILKF---------ARRRSPF-----NHPTVMFRKSKVLAVGGYQDLPLVEDYALWARM 183
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-108 5.68e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 56.59  E-value: 5.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   3 VTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIaHPHNLGPVAAFNDGLAAASG 82
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLL-HQANAGVSVARNTGLAVATG 86

                          90       100
                  ....*....|....*....|....*.
gi 1801978541  83 EFLIRLDADDLLTPGSVARSVALAEK 108
Cdd:PRK10073   87 KYVAFPDADDVVYPTMYETLMTMALE 112
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 5-125 2.14e-08

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 53.39  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   5 VIIPCFNYARFLPGAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQ-VIAHPHNLGPVAAFNDGLAAASGE 83
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELAALYIRRVlVVRDKENGGKAGALNAGLRHAKGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1801978541  84 FLIRLDADDLLTPGSVARSVALAEKHPQVGMVYGYPVPFSGS 125
Cdd:cd06423    81 IVVVLDADTILEPDALKRLVVPFFADPKVGAVQGRVRVRNGS 122
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 51-115 5.67e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 51.79  E-value: 5.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1801978541  51 IAHDDARVQVIAHPHNLGPVAAFNDGLAAASGEFLIRLDADDLLTPGSVARSVALAEKHPQVGMV 115
Cdd:cd04186    44 LRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVVEPGALLELLDAAEQDPDVGIV 108
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-130 1.05e-07

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 52.20  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   2 TVTVIIPCFNYARFLPGAIAS--ALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDdaRVQVIAHPHNLGPVAAFNDGLAA 79
Cdd:cd06439    30 TVTIIIPAYNEEAVIEAKLENllALDYPRDRLEIIVVSDGSTDGTAEIAREYADK--GVKLLRFPERRGKAAALNRALAL 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1801978541  80 ASGEFLIRLDADDLLTPGSVARSVALAEkHPQVGMV---YGYPVPFSGSAPESH 130
Cdd:cd06439   108 ATGEIVVFTDANALLDPDALRLLVRHFA-DPSVGAVsgeLVIVDGGGSGSGEGL 160
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 5-91 2.06e-06

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 47.57  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   5 VIIPCFNYARFLPGAIASALDqrdvdIDVIVVDD-------SSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGL 77
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLA-----VLEEGYDYeiivvddGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRAGF 75

                          90
                  ....*....|....
gi 1801978541  78 AAASGEFLIRLDAD 91
Cdd:cd04179    76 KAARGDIVVTMDAD 89
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-109 4.88e-06

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 47.23  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   2 TVTVIIPCFNYARFLPGAIASALDQRDVDIDVIVVDD--SSSDGSLAVARRIAHDDARVQVIahpHNLGPV--AAFNDGL 77
Cdd:cd02525     1 FVSIIIPVRNEEKYIEELLESLLNQSYPKDLIEIIVVdgGSTDGTREIVQEYAAKDPRIRLI---DNPKRIqsAGLNIGI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1801978541  78 AAASGEFLIRLDADDLLTPGSVARSVALAEKH 109
Cdd:cd02525    78 RNSRGDIIIRVDAHAVYPKDYILELVEALKRT 109
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 43-91 1.10e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 43.15  E-value: 1.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1801978541  43 GSLAVARRI--AHDDARVQVIAHPHNLGPVAAFNDGLAAASGEFLIRLDAD 91
Cdd:PLN02726   53 GTQDVVKQLqkVYGEDRILLRPRPGKLGLGTAYIHGLKHASGDFVVIMDAD 103
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 2-140 6.23e-04

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 40.73  E-value: 6.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   2 TVTVIIPCFNYARFLPGAIASA---------LDqrdvdidvivvddsssDGS----LAVARriahdDARVQVIAHPhNLG 68
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVkwavdeiivVD----------------SGStdrtVEIAK-----EYGAKVYQRW-WDG 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  69 PVAAFNDGLAAASGEFLIRLDADDLLTPGSVARSVALAEKHPQVG-------MVYGYPVPFSGSAPESH-----RDRAKF 136
Cdd:cd02511    59 FGAQRNFALELATNDWVLSLDADERLTPELADEILALLATDDYDGyyvprrnFFLGRWIRHGGWYPDRQlrlfrRGKARF 138


                  ....
gi 1801978541 137 WDIW 140
Cdd:cd02511   139 EDGR 142
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
54-131 1.08e-03

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 40.36  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  54 DDARVQVIAHPHNLGPVAAFNDGLAAASGEFLIRLDADDLLTPGSVarSVALAEKHPQV-------------GMVYGYP- 119
Cdd:PRK10018   58 NDPRITYIHNDINSGACAVRNQAIMLAQGEYITGIDDDDEWTPNRL--SVFLAHKQQLVthaflyandyvcqGEVYSQPa 135

                          90
                  ....*....|...
gi 1801978541 120 -VPFSGSAPESHR 131
Cdd:PRK10018  136 sLPLYPKSPYSRR 148
Glyco_transf_21 pfam13506
Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2. ...
 60-180 1.49e-03

Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.


Pssm-ID: 433264 [Multi-domain]  Cd Length: 173  Bit Score: 38.80  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541  60 VIAHPHNLGP-VAAFNDGLAAASGEFLIRLDADDLLTPGSVaRSVALAEKHPQVGMVYGYPVpfsgSAPESHRDRAKFWD 138
Cdd:pfam13506   8 VGGPPVGVNPkVNNLLQGLEAAKYDLLVISDSDIRVPPDYL-RDLLAPLADPKVGLVTSPPV----GSDPKGLAAALEAA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1801978541 139 IWSGASWLERRCQLGVNCITSPEVLMRASVVDSVGGQRALAH 180
Cdd:pfam13506  83 FFNTLAGVLQAALSGIGFAVGMSMAFRRADLERIGGFEALAD 124
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 5-91 3.03e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 38.23  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801978541   5 VIIPCFNYARFLP---GAIASALDQRDVDIDVIVVDDSSSDGSLAVARRIAHDDARVQVIAHPHNLGPVAAFNDGLAAAS 81
Cdd:cd04187     1 IVVPVYNEEENLPelyERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRVKVIRLSRNFGQQAALLAGLDHAR 80

                          90
                  ....*....|
gi 1801978541  82 GEFLIRLDAD 91
Cdd:cd04187    81 GDAVITMDAD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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