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Conserved domains on  [gi|1797002241|gb|QHH04997|]
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potassium transporter Kef [Vibrio parahaemolyticus]

Protein Classification

cation:proton antiporter family protein( domain architecture ID 18082866)

monovalent cation:proton antiporter family protein plays a role in controlling intracellular cation (such as K+ and Na+) and proton concentrations in a pH-dependent manner

CATH:  1.20.1530.20
Gene Ontology:  GO:0015078|GO:0140828
PubMed:  9537504
TCDB:  2.A.37

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RosB super family cl47355
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 1.20e-57

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG4651:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 201.36  E-value: 1.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   4 ILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGY-QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLSkeIWGGATA 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVLIgpFTPGLvADVELIEQLAEIGVILLLFGVGLEFSLKDLLA--VRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  81 HNILSTVFFALALSGL-KLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVVF 159
Cdd:COG4651    90 GALLQIALTTLLGFGIaLLLGWSLGES------LVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 160 L----TVSTGKVPEWYAIGL----------FALPLLRPLFYKLLDKVGHG---EMLVLFGIFFALVVGAgLFELVGMKPD 222
Cdd:COG4651   164 LvllpALAGGGGGLLGTLGLtllkvalfvaLMLVVGRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 223 LGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASLSL----TGIALALLFIVLLpIKGLLYFLTINHFKFR 298
Cdd:COG4651   243 LGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFllenPLPVLALLLIVLI-GKPLIAFLIVLALGYP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 299 VRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFIISAPLNRLGHKIYQHSGKWLQETAAEklnQRD 378
Cdd:COG4651   322 LRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARL---ERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 379 QLINPGHAQVLILGMGRIGTGAYDELRARYGKISLGIEIREEAAQQHRSEGRNVISGDATDPDFWERILDTGHVKLVLLA 458
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1797002241 459 MPHHQGNQTALEQLQRRNYKGQIAAIAEYPDQLEGLLESGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVV 523
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 1.20e-57

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 201.36  E-value: 1.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   4 ILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGY-QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLSkeIWGGATA 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVLIgpFTPGLvADVELIEQLAEIGVILLLFGVGLEFSLKDLLA--VRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  81 HNILSTVFFALALSGL-KLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVVF 159
Cdd:COG4651    90 GALLQIALTTLLGFGIaLLLGWSLGES------LVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 160 L----TVSTGKVPEWYAIGL----------FALPLLRPLFYKLLDKVGHG---EMLVLFGIFFALVVGAgLFELVGMKPD 222
Cdd:COG4651   164 LvllpALAGGGGGLLGTLGLtllkvalfvaLMLVVGRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 223 LGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASLSL----TGIALALLFIVLLpIKGLLYFLTINHFKFR 298
Cdd:COG4651   243 LGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFllenPLPVLALLLIVLI-GKPLIAFLIVLALGYP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 299 VRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFIISAPLNRLGHKIYQHSGKWLQETAAEklnQRD 378
Cdd:COG4651   322 LRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARL---ERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 379 QLINPGHAQVLILGMGRIGTGAYDELRARYGKISLGIEIREEAAQQHRSEGRNVISGDATDPDFWERILDTGHVKLVLLA 458
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1797002241 459 MPHHQGNQTALEQLQRRNYKGQIAAIAEYPDQLEGLLESGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVV 523
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 3-347 4.37e-35

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 135.46  E-value: 4.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGYQSN--DVIVTLADLGVTLLLFTIGLKLDVKTLlsKEIWGGA 78
Cdd:pfam00999   2 VLLILLALLAPLLARRLKLPPIVGLIIAGILLgpSGLGLISEvdEDLEVLSNLGLPPLLFLAGLELDLREL--RKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  79 TAHNILSTVFFALALSGLKLLGLTSLASMESgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVV 158
Cdd:pfam00999  80 LLLALLGVLIPFVLIGLLLYLLGLGIPLLEA---LLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 159 FLTVSTGKVPE---------------WYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFFALVVGAGLF-ELVGMKPD 222
Cdd:pfam00999 157 LLAVLLALAQGvgggsdlgwllliflVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLaEALGVSGI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 223 LGALILGMMLAGHRKASELSKSLFN-MKELFLVCFFLNIGLSASLS-----LTGIALALLFIVLLpIKGLLYFLTINHFK 296
Cdd:pfam00999 237 LGAFLAGLVLSEYPFANKLSEKLEPfGYGLFNPLFFVLVGLSLDLSslllsVWILVLLALVAILL-GRFLGVFLLLRLLG 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1797002241 297 FRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFII 347
Cdd:pfam00999 316 LSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLV 366
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 3-439 1.37e-22

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 101.64  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCLHAFGYQ---SNDVIVTLADLGVTLLLFTIGLKLDVKTL--LSKEIWGG 77
Cdd:PRK03659   11 VLFLFAAVVAVPLAQRLGIGAVLGYLLAGIAIGPWGLGfisDVDEILHFSELGVVFLMFIIGLELNPSKLwqLRRSIFGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  78 ATAHNILSTVFFALALSglkLLGLTSLASMESGqilllaFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIfAV 157
Cdd:PRK03659   91 GAAQVLLSAAVLAGLLM---LTDFSWQAAVVGG------IGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDL-AV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 158 V-------FLTVSTGKVPEWYAIGLFALP----------LLRPLFyKLLDKVGHGEMLVLFGIFfaLVVGAGLF-ELVGM 219
Cdd:PRK03659  161 IpalalvpLLAGSADEHFDWMKIGMKVLAfagmliggryLLRPLF-RFIAASGVREVFTAAALL--LVLGSALFmDALGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 220 KPDLGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASL-----SLTGIALALLfiVLLPIKGLLYFLTINH 294
Cdd:PRK03659  238 SMALGTFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLgvlytHLLWVLISVV--VLVAVKGLVLYLLARL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 295 FKFRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSfIISAPLnrlghkIYQHSGKWLqetaAEKL 374
Cdd:PRK03659  316 YGLRSSERMQFAGVLSQGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLS-MMTTPL------LMKLIDKWL----ARRL 384

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 375 NQRDQL-----INPGHAQVLILGMGRIGTGAYDELRARYGKISLgIEIREEAAQQHRSEGRNVISGDATD 439
Cdd:PRK03659  385 NGPEEEdekpwVEDDKPQVIIVGFGRFGQVIGRLLMANKMRITV-LERDISAVNLMRKYGYKVYYGDATQ 453
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 8-263 8.69e-22

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 95.02  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   8 TAFLAGFIALKCSLPPLVGFLLAGFCLHAFGY---QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLSKEIWGGATAHNIL 84
Cdd:TIGR00932   3 AAVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLgliSNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  85 STVFFALALSGLKLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVVFLTVS- 163
Cdd:TIGR00932  83 LVPGVLLGLLLGHLLGLALGAA------VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLp 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 164 ----------------TGKVPEWYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFfaLVVGAGLF-ELVGMKPDLGAL 226
Cdd:TIGR00932 157 llatsastehvalallLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLL--LMFGSAYFaDLLGLSMALGAF 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1797002241 227 ILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLS 263
Cdd:TIGR00932 235 LAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMS 271
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-503 1.20e-57

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 201.36  E-value: 1.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   4 ILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGY-QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLSkeIWGGATA 80
Cdd:COG4651    12 LILGLAAVLGLLAQRLRQPPIVGYLLAGVLIgpFTPGLvADVELIEQLAEIGVILLLFGVGLEFSLKDLLA--VRKIALP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  81 HNILSTVFFALALSGL-KLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVVF 159
Cdd:COG4651    90 GALLQIALTTLLGFGIaLLLGWSLGES------LVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 160 L----TVSTGKVPEWYAIGL----------FALPLLRPLFYKLLDKVGHG---EMLVLFGIFFALVVGAgLFELVGMKPD 222
Cdd:COG4651   164 LvllpALAGGGGGLLGTLGLtllkvalfvaLMLVVGRRVIPWLLHRVARTrsrELFLLAVLAICLGVAY-LAALFGLSFA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 223 LGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASLSL----TGIALALLFIVLLpIKGLLYFLTINHFKFR 298
Cdd:COG4651   243 LGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFllenPLPVLALLLIVLI-GKPLIAFLIVLALGYP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 299 VRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFIISAPLNRLGHKIYQHSGKWLQETAAEklnQRD 378
Cdd:COG4651   322 LRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARL---ERD 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 379 QLINPGHAQVLILGMGRIGTGAYDELRARYGKISLGIEIREEAAQQHRSEGRNVISGDATDPDFWERILDTGHVKLVLLA 458
Cdd:COG4651   399 RPEESDLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAI 478

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1797002241 459 MPHHQGNQTALEQLQRRNYKGQIAAIAEYPDQLEGLLESGVDAAF 503
Cdd:COG4651   479 PAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVV 523
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-360 3.74e-44

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 160.31  E-value: 3.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGY-QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLS--KEIWGG 77
Cdd:COG0475    10 GLLLLAAVLAGLLARRLGLPSVLGYILAGILLgpSGLGLiEDSEALELLAELGVVLLLFLIGLELDLKRLRKmgRRALGI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  78 ATAHNILSTVFFALALSglkLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAV 157
Cdd:COG0475    90 GLLQVLLPFLLGFLLAL---LLGLSLAAA------LFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 158 VFLTV----------------STGKVPEWYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFFALVVgAGLFELVGMKP 221
Cdd:COG0475   161 LLLALvpalagggsvagslllALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLA-AALAELLGLSA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 222 DLGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASLSL---TGIALALLFIVLLPIKGLLYFLTINHFKFR 298
Cdd:COG0475   240 ALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSAllsNPLLALLLVLAAIVGKLLGAYLAARLFGLS 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797002241 299 VRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFIISAPLNRLGHKIYQ 360
Cdd:COG0475   320 RREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLAE 381
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 3-347 4.37e-35

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 135.46  E-value: 4.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCL--HAFGYQSN--DVIVTLADLGVTLLLFTIGLKLDVKTLlsKEIWGGA 78
Cdd:pfam00999   2 VLLILLALLAPLLARRLKLPPIVGLIIAGILLgpSGLGLISEvdEDLEVLSNLGLPPLLFLAGLELDLREL--RKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  79 TAHNILSTVFFALALSGLKLLGLTSLASMESgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVV 158
Cdd:pfam00999  80 LLLALLGVLIPFVLIGLLLYLLGLGIPLLEA---LLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 159 FLTVSTGKVPE---------------WYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFFALVVGAGLF-ELVGMKPD 222
Cdd:pfam00999 157 LLAVLLALAQGvgggsdlgwllliflVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLaEALGVSGI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 223 LGALILGMMLAGHRKASELSKSLFN-MKELFLVCFFLNIGLSASLS-----LTGIALALLFIVLLpIKGLLYFLTINHFK 296
Cdd:pfam00999 237 LGAFLAGLVLSEYPFANKLSEKLEPfGYGLFNPLFFVLVGLSLDLSslllsVWILVLLALVAILL-GRFLGVFLLLRLLG 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1797002241 297 FRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFII 347
Cdd:pfam00999 316 LSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLV 366
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 3-439 1.37e-22

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 101.64  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCLHAFGYQ---SNDVIVTLADLGVTLLLFTIGLKLDVKTL--LSKEIWGG 77
Cdd:PRK03659   11 VLFLFAAVVAVPLAQRLGIGAVLGYLLAGIAIGPWGLGfisDVDEILHFSELGVVFLMFIIGLELNPSKLwqLRRSIFGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  78 ATAHNILSTVFFALALSglkLLGLTSLASMESGqilllaFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIfAV 157
Cdd:PRK03659   91 GAAQVLLSAAVLAGLLM---LTDFSWQAAVVGG------IGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDL-AV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 158 V-------FLTVSTGKVPEWYAIGLFALP----------LLRPLFyKLLDKVGHGEMLVLFGIFfaLVVGAGLF-ELVGM 219
Cdd:PRK03659  161 IpalalvpLLAGSADEHFDWMKIGMKVLAfagmliggryLLRPLF-RFIAASGVREVFTAAALL--LVLGSALFmDALGL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 220 KPDLGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLSASL-----SLTGIALALLfiVLLPIKGLLYFLTINH 294
Cdd:PRK03659  238 SMALGTFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLgvlytHLLWVLISVV--VLVAVKGLVLYLLARL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 295 FKFRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSfIISAPLnrlghkIYQHSGKWLqetaAEKL 374
Cdd:PRK03659  316 YGLRSSERMQFAGVLSQGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLS-MMTTPL------LMKLIDKWL----ARRL 384

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 375 NQRDQL-----INPGHAQVLILGMGRIGTGAYDELRARYGKISLgIEIREEAAQQHRSEGRNVISGDATD 439
Cdd:PRK03659  385 NGPEEEdekpwVEDDKPQVIIVGFGRFGQVIGRLLMANKMRITV-LERDISAVNLMRKYGYKVYYGDATQ 453
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 8-263 8.69e-22

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 95.02  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   8 TAFLAGFIALKCSLPPLVGFLLAGFCLHAFGY---QSNDVIVTLADLGVTLLLFTIGLKLDVKTLLSKEIWGGATAHNIL 84
Cdd:TIGR00932   3 AAVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLgliSNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  85 STVFFALALSGLKLLGLTSLASmesgqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAVVFLTVS- 163
Cdd:TIGR00932  83 LVPGVLLGLLLGHLLGLALGAA------VVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLp 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 164 ----------------TGKVPEWYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFfaLVVGAGLF-ELVGMKPDLGAL 226
Cdd:TIGR00932 157 llatsastehvalallLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLL--LMFGSAYFaDLLGLSMALGAF 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1797002241 227 ILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLS 263
Cdd:TIGR00932 235 LAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMS 271
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 3-397 2.37e-21

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 97.76  E-value: 2.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   3 IILITTAFLAGFIALKCSLPPLVGFLLAGFCLHAFGYQ-SNDV--IVTLADLGVTLLLFTIGLKLDVKTL--LSKEIWGG 77
Cdd:PRK03562   11 LIYLGAAVLIVPIAVRLGLGSVLGYLIAGCIIGPWGLRlVTDVesILHFAEFGVVLMLFVIGLELDPQRLwkLRRSIFGG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  78 ATAHnilstvffaLALSGLKLLGLTSLASMESGQILLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQDIFAV 157
Cdd:PRK03562   91 GALQ---------MVACGGLLGLFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 158 VFLTV---------STGKVPEWY-------AIGLFALP---LLRPLFyKLLDKVGHGEMLVLFGIFfaLVVGAG-LFELV 217
Cdd:PRK03562  162 PLVAMipllaasgaSTTLGAFALsalkvagALALVVLGgryVTRPAL-RFVARSGLREVFTAVALF--LVFGFGlLMEEV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 218 GMKPDLGALILGMMLAGHRKASELSKSLFNMKELFLVCFFLNIGLS---ASLSLTGIALALLFIVLLPIKGLLYFLTINH 294
Cdd:PRK03562  239 GLSMALGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSidfGTLLENPLRILILLLGFLAIKIAMLWLLARP 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 295 FKFRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAIAVAVSLSFIISaPLNRLGHKiyqhsgKWLQETAAEkl 374
Cdd:PRK03562  319 LGVPRKQRRWFAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMAAT-PLLLVLLD------RLEQSRTEE-- 389

                         410       420
                  ....*....|....*....|...
gi 1797002241 375 NQRDQLINPGHAQVLILGMGRIG 397
Cdd:PRK03562  390 AREADEIDEQQPRVIIAGFGRFG 412
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
258-521 1.03e-19

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 89.40  E-value: 1.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 258 LNIGLSASLSLTGIALALLFIVLLPIKGLLYFLTINHFKFRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSDMLAAI 337
Cdd:COG1226     1 LGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 338 AVAVSLSFIISAPLNRLGHKIYQHSGKWLQETAAEKLNQRDQLinpgHAQVLILGMGRIGTGAYDELRARyGKISLGIEI 417
Cdd:COG1226    81 LLLVLLLLLLLLLLLLLLALLLLLLALAAREEEAEAAEDAIDL----EGHVIIAGFGRVGQIVARLLRAE-GIPFVVIDL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 418 REEAAQQHRSEGRNVISGDATDPDFWERiLDTGHVKLVLLAMPHHQGNQTALEQLQRRNYKGQIAAIAEYPDQLEGLLES 497
Cdd:COG1226   156 DPERVEELRRFGIKVYYGDATRPDVLEA-AGIERARALVVAIDDPEAALRIVELARELNPDLKIIARARDREHAEELRQA 234

                         250       260
                  ....*....|....*....|....
gi 1797002241 498 GVDAAFNIYSEAGSGFARHVCKQL 521
Cdd:COG1226   235 GADEVVRETFESALQLARHALEAL 258
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 388-504 1.20e-18

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 81.42  E-value: 1.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 388 VLILGMGRIGTGAYDELRAryGKISLGIEIREEAAQQHRSEGRNVISGDATDPDFWERIlDTGHVKLVLLAMPHHQGNQT 467
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSE--GGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEA-GIEEADAVIAATGDDEANIL 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1797002241 468 ALEQLQRRNYKGQIAAIAEYPDQLEGLLESGVDAAFN 504
Cdd:pfam02254  78 IVLLARELNPDKKIIARANDPEHAELLRRLGADHVIS 114
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 5-500 4.06e-18

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 87.46  E-value: 4.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241   5 LITT-------AFLAGFIALKCSLPPLVGFLLAGFCLHAF--GYQSNDVIVT-LADLGVTLLLFTIGLKLDVKTLLS-KE 73
Cdd:PRK10669    7 LITTivgglvlAFILGMLANRLRISPLVGYLLAGVLAGPFtpGFVADTKLAPeLAELGVILLMFGVGLHFSLKDLMAvKS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241  74 IW-GGATAHNILSTVFfALALSglKLLGLtslaSMESGqiLLLAFALSFSSTVFAVKTLQEKGELNATYATLAIGILVMQ 152
Cdd:PRK10669   87 IAiPGAIAQIAVATLL-GMALS--AVLGW----SLMTG--IVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 153 DIFAVVFLT------------------------VSTGKVPEWYAIGLFALPLLRPLFYKLLDKVGHGEMLVLFGIFFALV 208
Cdd:PRK10669  158 DLVMVLTLVllpavagmmeqgdvgfatlavdlgITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 209 VGAGLFELVGMKPDLGALILGMMLaghrKASELS----KSLFNMKELFLVCFFLNIG-LSASLSLTGIALALLFIVLLPI 283
Cdd:PRK10669  238 IAFGAVELFDVSFALGAFFAGMVL----NESELShraaHDTLPLRDAFAVLFFVSVGmLFDPMILIQQPLAVLATLAIIV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 284 --KGLLYFLTINHFKFRVRTSLLASLSLFNYSEFGLIVGGLAYKMGWMPSD----MLAAIAVAVSLSFIISAPLNRLGHK 357
Cdd:PRK10669  314 fgKSLAAFFLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAgqnlVLAGAILSIMLNPVLFTLLERYLAK 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 358 IYQHSGKWLQETAAEKLNQRDQLINpgHAqvLILGMGRIGTGAYDELRARyGKISLGIEIREEAAQQHRSEGRNVISGDA 437
Cdd:PRK10669  394 TETLEEQTLEEAIEEEKQIPVDICN--HA--LLVGYGRVGSLLGEKLLAA-GIPLVVIETSRTRVDELRERGIRAVLGNA 468

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1797002241 438 TDPDfwerILDTGHV---KLVLLAMP--HHQGNQTALEQLQRRNYKgqIAAIAEYPDQLEGLLESGVD 500
Cdd:PRK10669  469 ANEE----IMQLAHLdcaRWLLLTIPngYEAGEIVASAREKRPDIE--IIARAHYDDEVAYITERGAN 530
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 371-517 7.47e-09

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 57.00  E-value: 7.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797002241 371 AEKLNQRDQLINPGHAQVLILGMGRIGTGAYDELRARyGKISLGIEIREEAAQQHRSEGRNVISGDATDPDFWERiLDTG 450
Cdd:COG0569    81 ALRRRRMERGIKKLKMHVIIIGAGRVGRSLARELEEE-GHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEE-AGIE 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1797002241 451 HVKLVLLAMPHHQGNQTALEQLQRRNYKgQIAAIAEYPDQLEGLLESGVDAAFNIYSEAGSGFARHV 517
Cdd:COG0569   159 DADAVIAATGDDEANILACLLAKELGVP-RIIARANDPEYADLLERLGADVVISPERLAARRIARLL 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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