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Conserved domains on  [gi|1792550353|gb|QHD51879|]
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glycosyltransferase [Shewanella algae]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 17-314 3.83e-20

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03811:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 351  Bit Score: 90.88  E-value: 3.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  17 FFINSIELGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEELLEEFDLYCDLLYLHEFcflgclfssKNLSPRVVSLL 96
Cdd:cd03811     4 FVIPSLSGGGAERVLLNLANAL---DKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRV---------LKLIKLGLLKA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  97 PLSNKKIIKTLNISYIHVIDEITLVTACrfrdifatppviSVGVYHSKLFTW--GDNLDSRYFYFHPKRIFSSFLPSDNI 174
Cdd:cd03811    72 ILKLKRILKRAKPDVVISFLGFATYIVA------------KLAAARSKVIAWihSSLSKLYYLKKKLLLKLKLYKKADKI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 175 LFFNQASLDIATSYFKKSFPNSAVIPIGV-VDNVKPFPDERPYIKG----KIVSIGRLVEFKSYNEnVIRAIYEL-KAQC 248
Cdd:cd03811   140 VCVSKGIKEDLIRLGPSPPEKIEVIYNPIdIDRIRALAKEPILNEPedgpVILAVGRLDPQKGHDL-LIEAFAKLrKKYP 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1792550353 249 ALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVdySKFASVISDCWLFV------GSGTSIVEASALGVP 314
Cdd:cd03811   219 DVKLVILGDGPLREELEKLAKELGLAERVIFLGFQ--SNPYPYLKKADLFVlssryeGFPNVLLEAMALGTP 288
 
Name Accession Description Interval E-value
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 17-314 3.83e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 90.88  E-value: 3.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  17 FFINSIELGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEELLEEFDLYCDLLYLHEFcflgclfssKNLSPRVVSLL 96
Cdd:cd03811     4 FVIPSLSGGGAERVLLNLANAL---DKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRV---------LKLIKLGLLKA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  97 PLSNKKIIKTLNISYIHVIDEITLVTACrfrdifatppviSVGVYHSKLFTW--GDNLDSRYFYFHPKRIFSSFLPSDNI 174
Cdd:cd03811    72 ILKLKRILKRAKPDVVISFLGFATYIVA------------KLAAARSKVIAWihSSLSKLYYLKKKLLLKLKLYKKADKI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 175 LFFNQASLDIATSYFKKSFPNSAVIPIGV-VDNVKPFPDERPYIKG----KIVSIGRLVEFKSYNEnVIRAIYEL-KAQC 248
Cdd:cd03811   140 VCVSKGIKEDLIRLGPSPPEKIEVIYNPIdIDRIRALAKEPILNEPedgpVILAVGRLDPQKGHDL-LIEAFAKLrKKYP 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1792550353 249 ALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVdySKFASVISDCWLFV------GSGTSIVEASALGVP 314
Cdd:cd03811   219 DVKLVILGDGPLREELEKLAKELGLAERVIFLGFQ--SNPYPYLKKADLFVlssryeGFPNVLLEAMALGTP 288
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 218-332 2.88e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 67.30  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 218 KGKIVSIGRLVEFKSYnENVIRAIYELKAQcALDYY--IYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDC 295
Cdd:pfam00534   2 KKIILFVGRLEPEKGL-DLLIKAFALLKEK-NPNLKlvIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1792550353 296 WLFV------GSGTSIVEASALGVPslvgVESSDktVGMFGEI 332
Cdd:pfam00534  80 DVFVlpsryeGFGIVLLEAMACGLP----VIASD--VGGPPEV 116
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 198-385 9.74e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 41.45  E-value: 9.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 198 VIPIGV-VDNVKPFPDERPYIKGKIVS-IGRLVEFKSYN------ENVIRAIYELKAQCAldyyiygdGPNEKN------ 263
Cdd:NF038011  284 VIPNGIdLPRLAPLRAQRPAGIPPVVGlIGRVVPIKDIKtfiramRTVVRAMPEAEGWIV--------GPEEEDpayaae 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 264 LKKLVSKLGLEEKVHFMGrvdYSKFASVISDCWLFVGSGTS------IVEASALGVPSLV-----------GVESSDKTV 326
Cdd:NF038011  356 CRSLVASLGLQDKVKFLG---FQKIDDLLPQVGLMVLSSISealplvVLEAFAAGVPVVTtdvgscrqlieGLDEEDRAL 432

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1792550353 327 GMFGEISGF-DYNELTDAcvhsyssfILKLYLDDSYLKHSSAFGIEKSRHF----SMRESVRSI 385
Cdd:NF038011  433 GAAGEVVAIaDPQALARA--------ALDLLRDPQRWQAAQAAGLARVERYyteeLMFDRYREL 488
 
Name Accession Description Interval E-value
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 17-314 3.83e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 90.88  E-value: 3.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  17 FFINSIELGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEELLEEFDLYCDLLYLHEFcflgclfssKNLSPRVVSLL 96
Cdd:cd03811     4 FVIPSLSGGGAERVLLNLANAL---DKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRV---------LKLIKLGLLKA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  97 PLSNKKIIKTLNISYIHVIDEITLVTACrfrdifatppviSVGVYHSKLFTW--GDNLDSRYFYFHPKRIFSSFLPSDNI 174
Cdd:cd03811    72 ILKLKRILKRAKPDVVISFLGFATYIVA------------KLAAARSKVIAWihSSLSKLYYLKKKLLLKLKLYKKADKI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 175 LFFNQASLDIATSYFKKSFPNSAVIPIGV-VDNVKPFPDERPYIKG----KIVSIGRLVEFKSYNEnVIRAIYEL-KAQC 248
Cdd:cd03811   140 VCVSKGIKEDLIRLGPSPPEKIEVIYNPIdIDRIRALAKEPILNEPedgpVILAVGRLDPQKGHDL-LIEAFAKLrKKYP 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1792550353 249 ALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVdySKFASVISDCWLFV------GSGTSIVEASALGVP 314
Cdd:cd03811   219 DVKLVILGDGPLREELEKLAKELGLAERVIFLGFQ--SNPYPYLKKADLFVlssryeGFPNVLLEAMALGTP 288
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 25-387 7.60e-19

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 87.59  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  25 GGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEELLEEFDLYCDLLYLHEFCFLGCLFSSKNLSPRVVsllplsnkkii 104
Cdd:cd03801    14 GGAERHVRELARAL---AARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLR----------- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 105 kTLNISYIHVIDEITLVTACRFRDIFATPPVISVgvyHSKLFTWgdnlDSRYFYFHPK---RIFSSFLPSDNILFFNQAS 181
Cdd:cd03801    80 -LRKFDVVHAHGLLAALLAALLALLLGAPLVVTL---HGAEPGR----LLLLLAAERRllaRAEALLRRADAVIAVSEAL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 182 LDIATSYFKKSFPNSAVIPIGVVDNVKPFPDERPYIKGK----IVSIGRLVEFKSYNEnVIRAIYELKAQC-ALDYYIYG 256
Cdd:cd03801   152 RDELRALGGIPPEKIVVIPNGVDLERFSPPLRRKLGIPPdrpvLLFVGRLSPRKGVDL-LLEALAKLLRRGpDVRLVIVG 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 257 -DGPNEKNLKKLvsKLGLEEKVHFMGRVDYSKFASVISDCWLFV------GSGTSIVEASALGVPSLVgvesSDktVGMF 329
Cdd:cd03801   231 gDGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVlpsryeGFGLVVLEAMAAGLPVVA----TD--VGGL 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1792550353 330 GEISGFDYNELT--DACVHSYSSFILKLYLDDSYLKH-SSAFGIEKSRHFSMRESVRSIAN 387
Cdd:cd03801   303 PEVVEDGEGGLVvpPDDVEALADALLRLLADPELRARlGRAARERVAERFSWERVAERLLD 363
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 158-387 3.29e-15

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 76.55  E-value: 3.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 158 YFH----PKRIFSSFLPSDNILFFNQASLDIATSYFKKSFPNSA-------VIPIGVvdNVKPFP--------DERPYIK 218
Cdd:cd03817   122 YLHyipkGKLLVKAVVRKLVRRFYNHTDAVIAPSEKIKDTLREYgvkgpieVIPNGI--DLDKFEkplnteerRKLGLPP 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 219 GK--IVSIGRLVEFKSYNEnVIRAIYELKAQCALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDCW 296
Cdd:cd03817   200 DEpiLLYVGRLAKEKNIDF-LLRAFAELKKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAAD 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 297 LFVGSGTS------IVEASALGVPSLvgVESSDKTVGMFGE-ISGFDYNElTDACVhsySSFILKLYLDDSYLKHSSAFG 369
Cdd:cd03817   279 LFVFASTTetqglvYLEAMAAGLPVV--AAKDPAASELVEDgENGFLFEP-NDETL---AEKLLHLRENLELLRKLSKNA 352

                         250
                  ....*....|....*...
gi 1792550353 370 IEKSRHFSMRESVRSIAN 387
Cdd:cd03817   353 EISAREFAFAKSVEKLYE 370
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 14-314 2.51e-13

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 70.73  E-value: 2.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  14 KTIFFINSI-ELGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEELLEEFDLYCDLLYLHEFCFLGCLFSSKNLSpRV 92
Cdd:cd03820     1 KIAIVIPSIsNAGGAERVAINLANHL---AKKGYDVTIISLDSAEKPPFYELDDNIKIKNLGDRKYSHFKLLLKYFK-KV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  93 VSLlplsnKKIIKTLNISYIhvideITLVTACRFRDIFATPPVISVGVYHSKLFTWGDnldSRYFYFHPKRIFSSFlpsD 172
Cdd:cd03820    77 RRL-----RKYLKNNKPDVV-----ISFRTSLLTFLALIGLKSKLIVWEHNNYEAYNK---GLRRLLLRRLLYKRA---D 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 173 NILFFNQASLDiatSYFKKSFPNSAVIPigvvdNVKPFPDERPY--IKGK-IVSIGRLVEFKSYNeNVIRAIYEL-KAQC 248
Cdd:cd03820   141 KIVVLTEADKL---KKYKQPNSNVVVIP-----NPLSFPSEEPStnLKSKrILAVGRLTYQKGFD-LLIEAWALIaKKHP 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1792550353 249 ALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVdySKFASVISDCWLFV------GSGTSIVEASALGVP 314
Cdd:cd03820   212 DWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPT--KNIAEEYANSSIFVlssryeGFPMVLLEAMAYGLP 281
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 218-332 2.88e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 67.30  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 218 KGKIVSIGRLVEFKSYnENVIRAIYELKAQcALDYY--IYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDC 295
Cdd:pfam00534   2 KKIILFVGRLEPEKGL-DLLIKAFALLKEK-NPNLKlvIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1792550353 296 WLFV------GSGTSIVEASALGVPslvgVESSDktVGMFGEI 332
Cdd:pfam00534  80 DVFVlpsryeGFGIVLLEAMACGLP----VIASD--VGGPPEV 116
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 14-317 1.58e-12

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 68.39  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  14 KTIFFINSIelGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNNEElleefdlycDLLYLHEFCFLGCLFSSKNLSPR-- 91
Cdd:cd03808     1 KILFIVNVD--GGFQSFRLPLIKAL---VKKGYEVHVIAPDGDKLS---------DELKELGVKVIDIPILRRGINPLkd 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  92 VVSLLPLsnKKIIKTLNISYIHVIdeiTLVT------ACRfrdIFATPPVISVgvYHSKLFTWGDNLDSRYFYFHPKRIF 165
Cdd:cd03808    67 LKALFKL--YKLLKKEKPDIVHCH---TPKPgilgrlAAR---LAGVPKVIYT--VHGLGFVFTEGKLLRLLYLLLEKLA 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 166 SSFlpSDNILFFNQASLDIATSYFKKSFPNSAVIP-IGVvdNVKPF-PDERPYIKGKIV--SIGRLVEFKSYNEnVIRAI 241
Cdd:cd03808   137 LLF--TDKVIFVNEDDRDLAIKKGIIKKKKTVLIPgSGV--DLDRFqYSPESLPSEKVVflFVARLLKDKGIDE-LIEAA 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 242 YELKAQ-CALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDYskFASVISDCWLFV------GSGTSIVEASALGVP 314
Cdd:cd03808   212 KILKKKgPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLGFRSD--VPELLAESDVFVlpsyreGLPRSLLEAMAAGRP 289


                  ...
gi 1792550353 315 SLV 317
Cdd:cd03808   290 VIT 292
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 22-314 2.29e-12

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 67.68  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  22 IELGGVETFILRIAKhyyfNTSKK---IKVIVMSKR-SNNEELLEEFDLYCdllyLHEFCFLgclfSSKNLSPrvvsLLP 97
Cdd:cd03795    11 PDIGGIEQVIYDLAE----GLKKKgieVDVLCFSKEkETPEKEENGIRIHR----VKSFLNV----ASTPFSP----SYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  98 LSNKKIIKTLNISYIHVIDeiTLVTACRFRDIFATPPVISvgvYHSklftwgDNLDSRYFYFHPKRIFSSFLpsdnilff 177
Cdd:cd03795    75 KRFKKLAKEYDIIHYHFPN--PLADLLLFFSGAKKPVVVH---WHS------DIVKQKKLLKLYKPLMTRFL-------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 178 NQASLDIATS--YFKKS-----FPNSA-VIPIGVVDNVKPFPDE------RPYIKGKIV-SIGRLVEFKSYNenviraiY 242
Cdd:cd03795   136 RRADRIIATSpnYVETSptlreFKNKVrVIPLGIDKNVYNIPRVdfenikREKKGKKIFlFIGRLVYYKGLD-------Y 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 243 ELKAQCALDYYIY--GDGPNEKNLKKLVsKLGLEEKVHFMGRVDYSKFASVISDCWLFV--------GSGTSIVEASALG 312
Cdd:cd03795   209 LIEAAQYLNYPIVigGEGPLKPDLEAQI-ELNLLDNVKFLGRVDDEEKVIYLHLCDVFVfpsvlrseAFGIVLLEAMMCG 287


                  ..
gi 1792550353 313 VP 314
Cdd:cd03795   288 KP 289
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 14-317 3.69e-11

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 64.26  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  14 KTIFFINSIELGGVETFILRIAKHYYfNTSKKIKVIVMSKRSNNEELLEEF--DLYCdllylhefcfLGclfSSKNLSPR 91
Cdd:cd03807     1 KVAHVITGLNVGGAETMLLRLLEHMD-KSRFEHVVISLTGDGVLGEELLAAgvPVVC----------LG---LSSGKDPG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  92 VVSLLplsnKKIIKTLNISYIHVIdeitlvtacRFR-DIFATPPVI---SVGVYHSKLFTWGdnldsrYFYFHPKRIFSS 167
Cdd:cd03807    67 VLLRL----AKLIRKRNPDVVHTW---------MYHaDLIGGLAAKlagGVKVIWSVRSSNI------PQRLTRLVRKLC 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 168 FLPSDNILFFNQASLDIATSYFKKSFPNSA--VIPIGV-VDNVKPFPDERPYIKGK---------IVSIGRLVEFKSYnE 235
Cdd:cd03807   128 LLLSKFSPATVANSSAVAEFHQEQGYAKNKivVIYNGIdLFKLSPDDASRARARRRlglaedrrvIGIVGRLHPVKDH-S 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 236 NVIRAIYELKAQCAlDYY--IYGDGPNEKNLKKLVSKLGLEEKVHFMG-RVDYSKFASVISdcwLFV------GSGTSIV 306
Cdd:cd03807   207 DLLRAAALLVETHP-DLRllLVGRGPERPNLERLLLELGLEDRVHLLGeRSDVPALLPAMD---IFVlssrteGFPNALL 282

                         330
                  ....*....|.
gi 1792550353 307 EASALGVPSLV 317
Cdd:cd03807   283 EAMACGLPVVA 293
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 155-387 1.06e-10

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 62.77  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 155 RYFYFHPKR---IFSSFLP-----SDNILFFNQASLDIATSYFKKSFPNSAVIPIGVVDNVKPFPDERPYIKGK------ 220
Cdd:cd03809   115 RYPEFFPKRfrlYYRLLLPislrrADAIITVSEATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESAAVLIAKYllpepy 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 221 IVSIGRLVEFKSYnENVIRAIYELKAQcALDYYIY---GDGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDCWL 297
Cdd:cd03809   195 FLYVGTLEPRKNH-ERLLKAFALLKKQ-GGDLKLVivgGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARA 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 298 FV------GSGTSIVEASALGVPSLVgvesSDKTVgmFGEISG--------FDYNELTDAcvhsyssfILKLYLDDSYLK 363
Cdd:cd03809   273 FVfpslyeGFGLPVLEAMACGTPVIA----SNISV--LPEVAGdaalyfdpLDPESIADA--------ILRLLEDPSLRE 338

                         250       260
                  ....*....|....*....|....
gi 1792550353 364 HSSAFGIEKSRHFSMRESVRSIAN 387
Cdd:cd03809   339 ELIRKGLERAKKFSWEKTAEKTLE 362
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 195-338 1.58e-10

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 62.40  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 195 NSAVIPIGVvDNVKPFPDERPYIKGK----IVSIGRLVEFKSYNEnVIRAIYEL-KAQCALDYYIYGDGPNEKNLKKLVS 269
Cdd:cd03798   174 RVDVIPNGV-DPARFQPEDRGLGLPLdafvILFVGRLIPRKGIDL-LLEAFARLaKARPDVVLLIVGDGPLREALRALAE 251

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1792550353 270 KLGLEEKVHFMGRVDYSKFASVISDCWLFV------GSGTSIVEASALGVPslvgVESSDktVGMFGEISGFDYN 338
Cdd:cd03798   252 DLGLGDRVTFTGRLPHEQVPAYYRACDVFVlpsrheGFGLVLLEAMACGLP----VVATD--VGGIPEVVGDPET 320
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
220-314 2.64e-10

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 58.29  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 220 KIVSIGRLVEfksYNENV---IRAIYELKAQ-CALDYYIYGDGPNEKnLKKLVSklGLEEKVHFMGRVDysKFASVISDC 295
Cdd:pfam13692   3 VILFVGRLHP---NVKGVdylLEAVPLLRKRdNDVRLVIVGDGPEEE-LEELAA--GLEDRVIFTGFVE--DLAELLAAA 74

                          90       100
                  ....*....|....*....|....*
gi 1792550353 296 WLFV------GSGTSIVEASALGVP 314
Cdd:pfam13692  75 DVFVlpslyeGFGLKLLEAMAAGLP 99
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 14-326 7.55e-10

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 60.00  E-value: 7.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  14 KTIFFINSIELGGVETFILRIAKhyYFNtSKKIKVIVMSKRSNNEELLEEF-DLYCDLLYLHefcflgclFSSKNLSPRV 92
Cdd:cd03812     1 KILHIVGGMNVGGIETFLMNLYR--KLD-KSKIEFDFLATSDDKGEYDEELeELGGKIFYIP--------PKKKNIIKYF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  93 VSLLplsnkKIIKTLNISYIHV-IDEITLVTACRFRDIFatppvISVGVYHSKLFTWGDNLDSRYFYFHPKRIFSSFlpS 171
Cdd:cd03812    70 IKLL-----KLIKKEKYDIVHVhGSSSNGIILLLAAKAG-----VPVRIAHSHNTKDSSIKLRKIRKNVLKKLIERL--S 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 172 DNILffnQASLDIATSYFKKSFP-NSAVIPIGVVDNVKPFPDE------RPYIK-GKIV--SIGRLVEFKSYnENVIRAI 241
Cdd:cd03812   138 TKYL---ACSEDAGEWLFGEVENgKFKVIPNGIDIEKYKFNKEkrrkrrKLLILeDKLVlgHVGRFNEQKNH-SFLIDIF 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 242 YELKAQCAlDYYIY--GDGPNEKNLKKLVSKLGLEEKVHFMGRV-DYSKFASViSDCWLFV----GSGTSIVEASALGVP 314
Cdd:cd03812   214 EELKKKNP-NVKLVlvGEGELKEKIKEKVKELGLEDKVIFLGFRnDVSEILSA-MDVFLFPslyeGLPLVAVEAQASGLP 291

                         330
                  ....*....|..
gi 1792550353 315 SLVGVESSDKTV 326
Cdd:cd03812   292 CLLSDTITKECD 303
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 16-314 2.22e-09

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 58.52  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  16 IFFINS-IELGGVETFILRIAKHYyfnTSKKIKVIVMSKRSNneeLLEEFDLYCDLLYLHEFCFLGCLFSSKNLsprvvs 94
Cdd:cd03819     1 ILMLTPaLEIGGAETYILDLARAL---AERGHRVLVVTAGGP---LLPRLRQIGIGLPGLKVPLLRALLGNVRL------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  95 llplsnKKIIKTLNISYIHV-IDEITLVT--ACRFRDIfatPPVISVgvyHSklftwgdnldSRYFYFHPKRifSSFLPS 171
Cdd:cd03819    69 ------ARLIRRERIDLIHAhSRAPAWLGwlASRLTGV---PLVTTV---HG----------SYLATYHPKD--FALAVR 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 172 DNILFFnqasldIATSYFKKS--------FPN-SAVIPIGV-VDNVKPFPDERPYIKGKIVS-------IGRLVEFKSYn 234
Cdd:cd03819   125 ARGDRV------IAVSELVRDhliealgvDPErIRVIPNGVdTDRFPPEAEAEERAQLGLPEgkpvvgyVGRLSPEKGW- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 235 ENVIRAIYELKAQCALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDysKFASVISDCWLFVGS------GTSIVEA 308
Cdd:cd03819   198 LLLVDAAAELKDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGFRE--DVPAALAASDVVVLPslheefGRVALEA 275


                  ....*.
gi 1792550353 309 SALGVP 314
Cdd:cd03819   276 MACGTP 281
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 222-317 1.12e-07

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 52.41  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 222 VSIGRLVEFKSYNEnVIRAIYELKAQCA-LDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMG-RVDYSKFASVISDCWLFV 299
Cdd:cd01635   114 VSVGRLVPEKGIDL-LLEALALLKARLPdLVLVLVGGGGEREEEEALAAALGLLERVVIIGgLVDDEVLELLLAAADVFV 192

                          90       100
                  ....*....|....*....|....
gi 1792550353 300 ------GSGTSIVEASALGVPSLV 317
Cdd:cd01635   193 lpsrseGFGLVLLEAMAAGKPVIA 216
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 185-314 1.51e-06

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 49.75  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 185 ATSYF--KKSFPNSAVIPI--GV-VDNVKPFPDERPYIKGK---------IVSIGRLVEFKSYnENVIRAIYELKAQCaL 250
Cdd:cd04951   141 ALDEFiaKKAFSKNKSVPVynGIdLNKFKKDINVRLKIRNKlnlkndefvILNVGRLTEAKDY-PNLLLAISELILSK-N 218

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 251 DY--YIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDCW----LFVGSGTSIVEASALGVP 314
Cdd:cd04951   219 DFklLIAGDGPLRNELERLICNLNLVDRVILLGQISNISEYYNAADLFvlssEWEGFGLVVAEAMACERP 288
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 194-316 3.90e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 48.45  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 194 PNSAVIPIGVVDNVKPFPDERPYIKGKIVSIGRLVEFKSYNEnVIRAIYELKAQC-ALDYYIYGDGPNEKNLKKLVSKLG 272
Cdd:cd04949   136 PPIFTIPVGYVDQLDTAESNHERKSNKIITISRLAPEKQLDH-LIEAVAKAVKKVpEITLDIYGYGEEREKLKKLIEELH 214

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1792550353 273 LEEKVHFMGrvdY-SKFASVISDCWLFV------GSGTSIVEASALGVPSL 316
Cdd:cd04949   215 LEDNVFLKG---YhSNLDQEYQDAYLSLltsqmeGFGLTLMEAIGHGLPVV 262
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 30-363 9.78e-06

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 47.34  E-value: 9.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353  30 FILRIAKHYYFNTSKKIKVIVMSKRsnneelleefdlyCDLLYLHEFCFLgclfssknlsprvvslLPLSNKKIIKTLNI 109
Cdd:cd03794    74 LIRRLLNYLSFALAALLKLLVREER-------------PDVIIAYSPPIT----------------LGLAALLLKKLRGA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 110 SYIHVIdeitlvtacrfRDIFatPP-VISVGVYHSKLFTWGDNLDSRYFYFHPKRIFSsflpsdnilffnqASLDIATSY 188
Cdd:cd03794   125 PFILDV-----------RDLW--PEsLIALGVLKKGSLLKLLKKLERKLYRLADAIIV-------------LSPGLKEYL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 189 FKKSFP--NSAVIPIGV-----VDNVKPFPDERPYIKGKIV-----SIGrlvefKSYN-ENVIRAIYELKAQCALDYYIY 255
Cdd:cd03794   179 LRKGVPkeKIIVIPNWAdleefKPPPKDELRKKLGLDDKFVvvyagNIG-----KAQGlETLLEAAERLKRRPDIRFLFV 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 256 GDGPNEKNLKKLVSKLGLeEKVHFMGRVDYSKFASVIS--DCWLFVGSGTS---------IVEASALGVPsLVGVESSDK 324
Cdd:cd03794   254 GDGDEKERLKELAKARGL-DNVTFLGRVPKEEVPELLSaaDVGLVPLKDNPanrgsspskLFEYMAAGKP-ILASDDGGS 331

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1792550353 325 TVGMFGEISGF-----DYNELTDAcvhsyssfILKLYLDDSYLK 363
Cdd:cd03794   332 DLAVEINGCGLvvepgDPEALADA--------ILELLDDPELRR 367
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 235-317 2.07e-05

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 46.58  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 235 ENVIRAIYELKAQCALDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMGRVD-YSKFASvISDCWLFVGS----GTSIVEAS 309
Cdd:cd04962   212 DDVVRVFARVRRKIPAKLLLVGDGPERVPAEELARELGVEDRVLFLGKQDdVEELLS-IADLFLLPSEkesfGLAALEAM 290


                  ....*...
gi 1792550353 310 ALGVPSLV 317
Cdd:cd04962   291 ACGVPVVS 298
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 109-317 3.12e-05

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 45.82  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 109 ISYIHVIDEITLVTACRFRDIFATPPVISVgvyHSKLFTWgdNLDSRyfyfHPKRIFSSFLPSDNILffNQASLDIATS- 187
Cdd:cd03821    93 VVHIHGVWTYTSLAACKLARRRGIPYVVSP---HGMLDPW--ALQQK----HWKKRIALHLIERRNL--NNAALVHFTSe 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 188 --YFKKSFPN----SAVIPIGV-VDNVKP---------FPDERPYIkgkiVSIGRLVEFKSYNEnVIRAIYELKAQ-CAL 250
Cdd:cd03821   162 qeADELRRFGleppIAVIPNGVdIPEFDPglrdrrkhnGLEDRRII----LFLGRIHPKKGLDL-LIRAARKLAEQgRDW 236

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1792550353 251 DYYIYG-DGPNEKNLKKLVSKLGLEEKVHFMGRVDYSKFASVISDCWLFV------GSGTSIVEASALGVPSLV 317
Cdd:cd03821   237 HLVIAGpDDGAYPAFLQLQSSLGLGDRVTFTGPLYGEAKWALYASADLFVlpsyseNFGNVVAEALACGLPVVI 310
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 198-314 5.81e-05

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 44.92  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 198 VIPIGV-VDNVKPFPDERPYI--------KGKIVSIGRLVEFKSYnENVIRA---IYELKAQCALdyYIYG---DGPNEK 262
Cdd:cd03800   191 VVPPGVdLERFFPVDRAEARRarlllppdKPVVLALGRLDPRKGI-DTLVRAfaqLPELRELANL--VLVGgpsDDPLSM 267

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1792550353 263 ---NLKKLVSKLGLEEKVHFMGRVDYSKFASVISDCWLFVGS------GTSIVEASALGVP 314
Cdd:cd03800   268 dreELAELAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPslyepfGLTAIEAMACGTP 328
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 209-281 7.94e-05

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 44.36  E-value: 7.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1792550353 209 PFPDERPYIKGK--IVSIGRLVEFKSYnENVIRAIYELKAQCA-LDYYIYGDGPNEKNLKKLVSKLGLEEKVHFMG 281
Cdd:cd03799   163 RFKPRYLPLDGKirILTVGRLTEKKGL-EYAIEAVAKLAQKYPnIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLG 237
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 198-332 8.07e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 44.63  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 198 VIPIGVvdNVKPFPD---ERP-YIKGKIVSIGRLVEFKSYnENVIRAIYEL-KAQCALDYYIYG---DGPN-EKNLKKLV 268
Cdd:cd03813   271 VIPNGI--DIQRFAPareERPeKEPPVVGLVGRVVPIKDV-KTFIRAFKLVrRAMPDAEGWLIGpedEDPEyAQECKRLV 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 269 SKLGLEEKVHFMGRVD----YSKFA----SVISDcwlfvGSGTSIVEASALGVPSL---VG-----VESSDKTVGMFGEI 332
Cdd:cd03813   348 ASLGLENKVKFLGFQNikeyYPKLGllvlTSISE-----GQPLVILEAMASGVPVVatdVGscrelIYGADDALGQAGLV 422
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 198-385 9.74e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 41.45  E-value: 9.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 198 VIPIGV-VDNVKPFPDERPYIKGKIVS-IGRLVEFKSYN------ENVIRAIYELKAQCAldyyiygdGPNEKN------ 263
Cdd:NF038011  284 VIPNGIdLPRLAPLRAQRPAGIPPVVGlIGRVVPIKDIKtfiramRTVVRAMPEAEGWIV--------GPEEEDpayaae 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 264 LKKLVSKLGLEEKVHFMGrvdYSKFASVISDCWLFVGSGTS------IVEASALGVPSLV-----------GVESSDKTV 326
Cdd:NF038011  356 CRSLVASLGLQDKVKFLG---FQKIDDLLPQVGLMVLSSISealplvVLEAFAAGVPVVTtdvgscrqlieGLDEEDRAL 432

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1792550353 327 GMFGEISGF-DYNELTDAcvhsyssfILKLYLDDSYLKHSSAFGIEKSRHF----SMRESVRSI 385
Cdd:NF038011  433 GAAGEVVAIaDPQALARA--------ALDLLRDPQRWQAAQAAGLARVERYyteeLMFDRYREL 488
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 198-314 1.50e-03

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 40.51  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1792550353 198 VIPIGVvDNVKPFPDERPYIKGKIVSIGRLVEFKSYnENVIRAIYELKAQ---CALdyYIYGDGPNEKNLKKLVSKLGle 274
Cdd:cd05844   170 VHYIGI-DPAKFAPRDPAERAPTILFVGRLVEKKGC-DVLIEAFRRLAARhptARL--VIAGDGPLRPALQALAAALG-- 243

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1792550353 275 eKVHFMGRVDYSKFASVISDCWLFV------------GSGTSIVEASALGVP 314
Cdd:cd05844   244 -RVRFLGALPHAEVQDWMRRAEIFClpsvtaasgdseGLGIVLLEAAACGVP 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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