NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1776288496|gb|QGK77331|]
View 

N-acetyltransferase [Flavobacterium sp. SLB02]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006425)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to Escherichia coli uncharacterized protein YjdJ

CATH:  3.40.630.30
EC:  2.3.1.-|2.3.-.-
Gene Ontology:  GO:0008080|GO:0016746
PubMed:  10940244|9175471|15581578|27367672|26818562
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
1-87 1.38e-07

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


:

Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 44.76  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776288496  1 MEIKDNTFARQFETIVPEGLLS-VEYSFQEKKIFLTKINSPEGFDNQALIDVVLKNIMELIIEKKFRLMPIHPRIVLFIK 79
Cdd:COG2388    1 MEITHNEEKGRFELEVDGELAGeLTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAYFE 80


                 ....*...
gi 1776288496 80 KNPQYKEL 87
Cdd:COG2388   81 RHPEYADL 88
 
Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
1-87 1.38e-07

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 44.76  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776288496  1 MEIKDNTFARQFETIVPEGLLS-VEYSFQEKKIFLTKINSPEGFDNQALIDVVLKNIMELIIEKKFRLMPIHPRIVLFIK 79
Cdd:COG2388    1 MEITHNEEKGRFELEVDGELAGeLTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAYFE 80


                 ....*...
gi 1776288496 80 KNPQYKEL 87
Cdd:COG2388   81 RHPEYADL 88
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 11-87 4.15e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 32.88  E-value: 4.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1776288496 11 QFETIVPEGLLS--VEYSFQEKKIFLTKINSPEGFDNQALIDVVLKNIMELIIEKKFRLMPIHPRIVLFIKKNPQYKEL 87
Cdd:pfam14542  1 RFEIRVDGGAEVafLTYRRGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPLCSYVAAYLEKHPEYADL 79
 
Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
1-87 1.38e-07

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 44.76  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1776288496  1 MEIKDNTFARQFETIVPEGLLS-VEYSFQEKKIFLTKINSPEGFDNQALIDVVLKNIMELIIEKKFRLMPIHPRIVLFIK 79
Cdd:COG2388    1 MEITHNEEKGRFELEVDGELAGeLTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAYFE 80


                 ....*...
gi 1776288496 80 KNPQYKEL 87
Cdd:COG2388   81 RHPEYADL 88
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 11-87 4.15e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 32.88  E-value: 4.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1776288496 11 QFETIVPEGLLS--VEYSFQEKKIFLTKINSPEGFDNQALIDVVLKNIMELIIEKKFRLMPIHPRIVLFIKKNPQYKEL 87
Cdd:pfam14542  1 RFEIRVDGGAEVafLTYRRGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPLCSYVAAYLEKHPEYADL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH